CLEC12A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signaling, glycoprotein turnover, and roles in inflammation and immune response. The protein encoded by this gene is a negative regulator of granulocyte and monocyte function. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. This gene is closely linked to other CTL/CTLD superfamily members in the natural killer gene complex region on chromosome 12p13. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neutrophil mediated immunity (GO:0002446)7.30327147
2disruption of cells of other organism involved in symbiotic interaction (GO:0051818)6.51839428
3killing of cells in other organism involved in symbiotic interaction (GO:0051883)6.51839428
4neutrophil activation involved in immune response (GO:0002283)6.08449813
5positive regulation of interleukin-8 biosynthetic process (GO:0045416)6.06922764
6modulation of growth of symbiont involved in interaction with host (GO:0044144)5.81072125
7regulation of growth of symbiont in host (GO:0044126)5.81072125
8negative regulation of growth of symbiont in host (GO:0044130)5.81072125
9negative regulation of growth of symbiont involved in interaction with host (GO:0044146)5.81072125
10respiratory burst (GO:0045730)5.74676228
11myeloid leukocyte mediated immunity (GO:0002444)5.69598571
12negative regulation of cell killing (GO:0031342)5.65811913
13negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.65811913
14response to peptidoglycan (GO:0032494)5.50702852
15negative regulation of phagocytosis (GO:0050765)5.45874809
16response to fungus (GO:0009620)5.34514673
17positive regulation by symbiont of host defense response (GO:0052509)5.08808568
18modulation by symbiont of host defense response (GO:0052031)5.08808568
19modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.08808568
20modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.08808568
21positive regulation by organism of defense response of other organism involved in symbiotic interact5.08808568
22modulation by symbiont of host immune response (GO:0052553)5.08808568
23leukocyte mediated cytotoxicity (GO:0001909)5.02691665
24detection of bacterium (GO:0016045)4.92408424
25reactive oxygen species biosynthetic process (GO:1903409)4.91422539
26detection of molecule of bacterial origin (GO:0032490)4.88517360
27disruption of cells of other organism (GO:0044364)4.84514503
28killing of cells of other organism (GO:0031640)4.84514503
29defense response to fungus (GO:0050832)4.82565662
30leukocyte aggregation (GO:0070486)4.70698816
31detection of external biotic stimulus (GO:0098581)4.68088589
32antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.65164097
33immunoglobulin mediated immune response (GO:0016064)4.48327615
34cellular response to zinc ion (GO:0071294)4.43905973
35positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.42008442
36regulation of gamma-delta T cell activation (GO:0046643)4.26229863
37detection of biotic stimulus (GO:0009595)4.20474848
38regulation of interleukin-8 biosynthetic process (GO:0045414)4.18673956
39regulation of interferon-beta biosynthetic process (GO:0045357)4.15125081
40neutrophil activation (GO:0042119)4.14551013
41leukocyte migration involved in inflammatory response (GO:0002523)3.99705442
42macrophage activation involved in immune response (GO:0002281)3.98025038
43granulocyte activation (GO:0036230)3.89154101
44regulation of B cell receptor signaling pathway (GO:0050855)3.88727007
45negative regulation of lymphocyte mediated immunity (GO:0002707)3.86090447
46positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.79291184
47cell killing (GO:0001906)3.76928670
48myeloid cell activation involved in immune response (GO:0002275)3.75861051
49Arp2/3 complex-mediated actin nucleation (GO:0034314)3.75271321
50antigen processing and presentation via MHC class Ib (GO:0002475)3.73154822
51negative regulation of T cell mediated immunity (GO:0002710)3.64384399
52superoxide anion generation (GO:0042554)3.64136969
53response to host immune response (GO:0052572)3.62827181
54response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.62827181
55regulation of gamma-delta T cell differentiation (GO:0045586)3.60666747
56negative regulation of myeloid cell apoptotic process (GO:0033033)3.57241183
57positive regulation of interferon-alpha production (GO:0032727)3.51967698
58positive regulation of B cell differentiation (GO:0045579)3.50436742
59B cell receptor signaling pathway (GO:0050853)3.45054806
60hydrogen peroxide biosynthetic process (GO:0050665)3.44768449
61regulation of mast cell activation (GO:0033003)3.44290218
62regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.42968578
63negative regulation of leukocyte mediated immunity (GO:0002704)3.41167578
64mast cell activation (GO:0045576)3.39832524
65leukotriene metabolic process (GO:0006691)3.38423520
66regulation of tolerance induction (GO:0002643)3.37295114
67antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.36505577
68antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.36505577
69regulation of chemokine biosynthetic process (GO:0045073)3.36447913
70production of molecular mediator involved in inflammatory response (GO:0002532)3.35602284
71B cell mediated immunity (GO:0019724)3.33123677
72regulation of interferon-alpha production (GO:0032647)3.31956311
73cellular extravasation (GO:0045123)3.30477200
74positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.28540351
75positive regulation of mast cell activation (GO:0033005)3.25524109
76response to muramyl dipeptide (GO:0032495)3.24629545
77response to host (GO:0075136)3.24415320
78response to host defenses (GO:0052200)3.24415320
79response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.24415320
80regulation of mast cell degranulation (GO:0043304)3.24132586
81sequestering of metal ion (GO:0051238)3.23022229
82pinocytosis (GO:0006907)3.21969324
83defense response to protozoan (GO:0042832)3.21660509
84negative regulation of erythrocyte differentiation (GO:0045647)3.18437116
85natural killer cell mediated immunity (GO:0002228)3.15197257
86natural killer cell mediated cytotoxicity (GO:0042267)3.15197257
87regulation of regulated secretory pathway (GO:1903305)3.15055454
88leukocyte degranulation (GO:0043299)3.14046598
89positive regulation of cellular amide metabolic process (GO:0034250)3.13354639
90negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.12159839
91antigen processing and presentation of endogenous antigen (GO:0019883)3.11922211
92regulation of T cell tolerance induction (GO:0002664)3.09851193
93negative regulation of mast cell activation (GO:0033004)3.08864847
94positive thymic T cell selection (GO:0045059)3.07694310
95regulation of myeloid leukocyte mediated immunity (GO:0002886)3.03931531
96leukocyte mediated immunity (GO:0002443)3.03875659
97regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.02243521
98response to interleukin-15 (GO:0070672)3.01724133
99regulation of mast cell activation involved in immune response (GO:0033006)3.01243717
100regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.00291250
101regulation of T-helper 2 cell differentiation (GO:0045628)3.00040318
102positive regulation of gamma-delta T cell activation (GO:0046645)2.99727494
103regulation of B cell differentiation (GO:0045577)2.99536988
104activated T cell proliferation (GO:0050798)2.99433432
105cellular response to interferon-beta (GO:0035458)2.98362847
106response to protozoan (GO:0001562)2.96612151
107positive regulation of leukocyte degranulation (GO:0043302)2.94635525
108neutrophil chemotaxis (GO:0030593)2.93884259
109regulation of leukocyte degranulation (GO:0043300)2.93475767
110actin nucleation (GO:0045010)2.91917941
111positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.90920612
112positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.89549144
113T cell migration (GO:0072678)2.87167496
114negative thymic T cell selection (GO:0045060)2.86798529
115neutrophil migration (GO:1990266)2.85300805
116detection of other organism (GO:0098543)2.84758267
117angiogenesis involved in wound healing (GO:0060055)2.84436742
118type I interferon signaling pathway (GO:0060337)2.83995258
119cellular response to type I interferon (GO:0071357)2.83995258
120positive regulation of interleukin-1 beta secretion (GO:0050718)2.83558782
121microglial cell activation (GO:0001774)2.81531064
122response to type I interferon (GO:0034340)2.81254979
123lipopolysaccharide-mediated signaling pathway (GO:0031663)2.81155682
124positive regulation of regulated secretory pathway (GO:1903307)2.80365633
125negative T cell selection (GO:0043383)2.80005901
126positive regulation of antigen processing and presentation (GO:0002579)2.79733227
127regulation of alpha-beta T cell proliferation (GO:0046640)2.79576579
128macrophage differentiation (GO:0030225)2.79551314
129myeloid leukocyte activation (GO:0002274)2.76272460
130negative regulation of interleukin-8 production (GO:0032717)2.75920510
131leukotriene biosynthetic process (GO:0019370)2.75662170
132macrophage activation (GO:0042116)2.75285185
133response to interferon-beta (GO:0035456)2.74922673
134positive regulation of mast cell degranulation (GO:0043306)2.73661452
135positive regulation of mast cell activation involved in immune response (GO:0033008)2.73661452
136negative regulation of interleukin-12 production (GO:0032695)2.72785375
137negative regulation of interleukin-17 production (GO:0032700)2.71978492
138regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.70248652
139interferon-gamma-mediated signaling pathway (GO:0060333)2.65545755

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.54899700
2IRF8_21731497_ChIP-ChIP_J774_Mouse5.26458604
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.81751745
4MYB_21317192_ChIP-Seq_ERMYB_Mouse3.92734375
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.87104956
6* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.76158363
7SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.51590209
8* IRF8_27001747_Chip-Seq_BMDM_Mouse3.42983904
9FOXM1_23109430_ChIP-Seq_U2OS_Human3.18976445
10* IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.16251267
11NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.12732564
12* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.83307308
13SPI1_23547873_ChIP-Seq_NB4_Human2.73630682
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.71785805
15SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.60659752
16BRD4_27068464_Chip-Seq_AML-cells_Mouse2.57514975
17NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.55906631
18VDR_21846776_ChIP-Seq_THP-1_Human2.55256512
19STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.41883190
20E2F4_17652178_ChIP-ChIP_JURKAT_Human2.41763674
21IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.40952431
22SCL_19346495_ChIP-Seq_HPC-7_Human2.30817111
23RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.24035387
24Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.23504608
25STAT4_19710469_ChIP-ChIP_TH1__Mouse2.19757160
26VDR_24763502_ChIP-Seq_THP-1_Human2.18114187
27ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.16789167
28FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.12374319
29ELF1_17652178_ChIP-ChIP_JURKAT_Human2.11007724
30STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.01540360
31VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.01290198
32* RUNX1_22412390_ChIP-Seq_EML_Mouse1.95466570
33FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.93967209
34MYB_26560356_Chip-Seq_TH2_Human1.81634346
35MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.81533248
36FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.79132646
37SMAD_19615063_ChIP-ChIP_OVARY_Human1.78859164
38SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.77519822
39EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.75725450
40PU_27001747_Chip-Seq_BMDM_Mouse1.69603414
41SPI1_23127762_ChIP-Seq_K562_Human1.65813362
42HOXB4_20404135_ChIP-ChIP_EML_Mouse1.60841685
43* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.55544713
44MAF_26560356_Chip-Seq_TH1_Human1.55087474
45MYB_26560356_Chip-Seq_TH1_Human1.55019683
46SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.54970851
47TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.53943433
48GATA1_22025678_ChIP-Seq_K562_Human1.51997430
49PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.50683885
50TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.48921097
51KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.48074298
52NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.47356408
53SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.45909746
54ERG_20887958_ChIP-Seq_HPC-7_Mouse1.44090745
55CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.43895339
56* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.41633365
57MYC_22102868_ChIP-Seq_BL_Human1.41066688
58FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.40588562
59GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.39340239
60* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.38985439
61GATA2_22383799_ChIP-Seq_G1ME_Mouse1.38761784
62KDM2B_26808549_Chip-Seq_SUP-B15_Human1.37818397
63GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.37299404
64RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.35967647
65E2F1_21310950_ChIP-Seq_MCF-7_Human1.34874760
66UTX_26944678_Chip-Seq_JUKART_Human1.34541536
67LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.32705692
68CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.32126544
69GATA1_22383799_ChIP-Seq_G1ME_Mouse1.31169763
70MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.29824851
71PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.29033705
72CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.26086017
73KDM2B_26808549_Chip-Seq_DND41_Human1.24451318
74* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.22793044
75GATA1_19941826_ChIP-Seq_K562_Human1.22538214
76TFEB_21752829_ChIP-Seq_HELA_Human1.18530532
77KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.17836140
78EST1_17652178_ChIP-ChIP_JURKAT_Human1.17636756
79KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.15472119
80IKZF1_21737484_ChIP-ChIP_HCT116_Human1.13125777
81GATA3_26560356_Chip-Seq_TH2_Human1.11448722
82* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09577207
83E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.08885912
84VDR_23849224_ChIP-Seq_CD4+_Human1.08618697
85RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.08215922
86FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.08131424
87STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.07360960
88PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06313265
89GABP_17652178_ChIP-ChIP_JURKAT_Human1.05238183
90GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.05157778
91GATA2_21666600_ChIP-Seq_HMVEC_Human1.05040086
92GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04507979
93VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.04266682
94GATA2_19941826_ChIP-Seq_K562_Human1.04057872
95RUNX_20019798_ChIP-Seq_JUKART_Human1.03280407
96ELK1_19687146_ChIP-ChIP_HELA_Human1.01455541
97FOXP3_21729870_ChIP-Seq_TREG_Human1.01190606
98GATA3_27048872_Chip-Seq_THYMUS_Human0.99632242
99VDR_24787735_ChIP-Seq_THP-1_Human0.94393233
100PU.1_20513432_ChIP-Seq_Bcells_Mouse0.91935505
101JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.91115985
102NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.90663270
103TCF7_22412390_ChIP-Seq_EML_Mouse0.90469566
104RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90038429
105MYC_18358816_ChIP-ChIP_MESCs_Mouse0.89216786
106NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.89182861
107GATA1_19941827_ChIP-Seq_MEL86_Mouse0.88126873
108THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.86782781
109SRF_21415370_ChIP-Seq_HL-1_Mouse0.85462659
110CIITA_25753668_ChIP-Seq_RAJI_Human0.84123398
111KDM2B_26808549_Chip-Seq_JURKAT_Human0.83157731
112MAF_26560356_Chip-Seq_TH2_Human0.82462322
113E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.81666227
114CREB1_15753290_ChIP-ChIP_HEK293T_Human0.81349517
115MYC_18555785_ChIP-Seq_MESCs_Mouse0.80806634
116ELK3_25401928_ChIP-Seq_HUVEC_Human0.78517336
117SMRT_27268052_Chip-Seq_Bcells_Human0.78493810
118SPI1_20517297_ChIP-Seq_HL60_Human0.77870250
119BCL6_27268052_Chip-Seq_Bcells_Human0.77732855
120PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.77485082
121CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.77258492
122NCOR1_26117541_ChIP-Seq_K562_Human0.76756328
123GATA1_19941827_ChIP-Seq_MEL_Mouse0.76591699
124STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.75052409
125STAT6_21828071_ChIP-Seq_BEAS2B_Human0.72168386
126BCOR_27268052_Chip-Seq_Bcells_Human0.70144269
127STAT1_20625510_ChIP-Seq_HELA_Human0.69493514

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.19801045
2MP0003436_decreased_susceptibility_to4.07505294
3MP0009785_altered_susceptibility_to3.57642826
4MP0003303_peritoneal_inflammation3.51504059
5MP0002419_abnormal_innate_immunity3.49711943
6MP0003172_abnormal_lysosome_physiology3.06456120
7MP0002148_abnormal_hypersensitivity_rea2.99809919
8MP0005025_abnormal_response_to2.94480395
9MP0005000_abnormal_immune_tolerance2.83366217
10MP0005058_abnormal_lysosome_morphology2.78328545
11MP0002396_abnormal_hematopoietic_system2.63881517
12MP0003183_abnormal_peptide_metabolism2.61619356
13MP0002452_abnormal_antigen_presenting2.47940604
14MP0005464_abnormal_platelet_physiology2.46243847
15MP0000569_abnormal_digit_pigmentation2.37568361
16MP0003724_increased_susceptibility_to2.34177221
17MP0002420_abnormal_adaptive_immunity2.33109990
18MP0001819_abnormal_immune_cell2.32660376
19MP0001800_abnormal_humoral_immune2.30496925
20MP0002723_abnormal_immune_serum2.28272904
21MP0005174_abnormal_tail_pigmentation2.22375523
22MP0005387_immune_system_phenotype2.16042127
23MP0001790_abnormal_immune_system2.16042127
24MP0000685_abnormal_immune_system2.06029459
25MP0002166_altered_tumor_susceptibility2.04905473
26MP0001533_abnormal_skeleton_physiology2.02708359
27MP0005671_abnormal_response_to2.02097024
28MP0002006_tumorigenesis1.90177894
29MP0001845_abnormal_inflammatory_respons1.85117783
30MP0002405_respiratory_system_inflammati1.84848672
31MP0005397_hematopoietic_system_phenotyp1.82238322
32MP0001545_abnormal_hematopoietic_system1.82238322
33MP0003693_abnormal_embryo_hatching1.81797227
34MP0001853_heart_inflammation1.81573091
35MP0006082_CNS_inflammation1.79838409
36MP0002398_abnormal_bone_marrow1.79650460
37MP0000716_abnormal_immune_system1.77542643
38MP0000858_altered_metastatic_potential1.75912632
39MP0000343_altered_response_to1.71981387
40MP0000015_abnormal_ear_pigmentation1.71661980
41MP0000465_gastrointestinal_hemorrhage1.65972833
42MP0010307_abnormal_tumor_latency1.62072274
43MP0000490_abnormal_crypts_of1.61208038
44MP0010155_abnormal_intestine_physiology1.60599273
45MP0002132_abnormal_respiratory_system1.59732587
46MP0000689_abnormal_spleen_morphology1.58236767
47MP0009278_abnormal_bone_marrow1.52707959
48MP0002429_abnormal_blood_cell1.52582367
49MP0008469_abnormal_protein_level1.49644677
50MP0010094_abnormal_chromosome_stability1.49310213
51MP0002722_abnormal_immune_system1.46507432
52MP0009764_decreased_sensitivity_to1.43651997
53MP0003656_abnormal_erythrocyte_physiolo1.40743821
54MP0004808_abnormal_hematopoietic_stem1.39989914
55MP0003075_altered_response_to1.35945534
56MP0009333_abnormal_splenocyte_physiolog1.35843578
57MP0003448_altered_tumor_morphology1.35822939
58MP0005451_abnormal_body_composition1.32476510
59MP0003191_abnormal_cellular_cholesterol1.29175771
60MP0003111_abnormal_nucleus_morphology1.27651675
61MP0008057_abnormal_DNA_replication1.26995884
62MP0003300_gastrointestinal_ulcer1.25818647
63MP0008004_abnormal_stomach_pH1.21223807
64MP0004381_abnormal_hair_follicle1.19478106
65MP0004782_abnormal_surfactant_physiolog1.18690890
66MP0004947_skin_inflammation1.12886316
67MP0003763_abnormal_thymus_physiology1.10228689
68MP0003077_abnormal_cell_cycle1.10051902
69MP0003186_abnormal_redox_activity1.08387547
70MP0005075_abnormal_melanosome_morpholog1.06491076
71MP0000604_amyloidosis1.05686233
72MP0001873_stomach_inflammation1.04079021
73MP0001851_eye_inflammation1.03097560
74MP0003806_abnormal_nucleotide_metabolis1.01984909
75MP0009763_increased_sensitivity_to0.99577399
76MP0002095_abnormal_skin_pigmentation0.99476352
77MP0002277_abnormal_respiratory_mucosa0.98040520
78MP0002019_abnormal_tumor_incidence0.97471247
79MP0005310_abnormal_salivary_gland0.97245031
80MP0009840_abnormal_foam_cell0.95793815
81MP0001663_abnormal_digestive_system0.92877645
82MP0005164_abnormal_response_to0.92508872
83MP0004510_myositis0.91849998
84MP0000703_abnormal_thymus_morphology0.91751880
85MP0000371_diluted_coat_color0.91032340
86MP0002998_abnormal_bone_remodeling0.87609221
87MP0005166_decreased_susceptibility_to0.85487175
88MP0005390_skeleton_phenotype0.82188112
89MP0000249_abnormal_blood_vessel0.81710302
90MP0006054_spinal_hemorrhage0.79026255
91MP0003866_abnormal_defecation0.77600348
92MP0008007_abnormal_cellular_replicative0.76725174
93MP0003690_abnormal_glial_cell0.74259015
94MP0008058_abnormal_DNA_repair0.72843603
95MP0009765_abnormal_xenobiotic_induced0.71088618
96MP0003566_abnormal_cell_adhesion0.70217170
97MP0008873_increased_physiological_sensi0.69972832
98MP0001986_abnormal_taste_sensitivity0.68628908
99MP0002933_joint_inflammation0.66893428
100MP0003828_pulmonary_edema0.65740187
101MP0000313_abnormal_cell_death0.65570569
102MP0002009_preneoplasia0.64680469
103MP0005076_abnormal_cell_differentiation0.63065065
104MP0004130_abnormal_muscle_cell0.62605997
105MP0008874_decreased_physiological_sensi0.62365933
106MP0004957_abnormal_blastocyst_morpholog0.62347537
107MP0003045_fibrosis0.61026033
108MP0002332_abnormal_exercise_endurance0.58537399
109MP0003221_abnormal_cardiomyocyte_apopto0.56756749
110MP0003795_abnormal_bone_structure0.56745111
111MP0003091_abnormal_cell_migration0.56175892
112MP0005083_abnormal_biliary_tract0.56042122
113MP0004883_abnormal_blood_vessel0.55923572
114MP0004484_altered_response_of0.55386235
115MP0005319_abnormal_enzyme/_coenzyme0.54540140
116MP0005388_respiratory_system_phenotype0.53473418
117MP0002133_abnormal_respiratory_system0.53473418
118MP0008260_abnormal_autophagy0.52931692
119MP0005167_abnormal_blood-brain_barrier0.52779297
120MP0000920_abnormal_myelination0.52583239
121MP0005376_homeostasis/metabolism_phenot0.50869100

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)7.60353869
2Recurrent bacterial skin infections (HP:0005406)6.92381662
3Eczematoid dermatitis (HP:0000976)6.43723822
4Recurrent gram-negative bacterial infections (HP:0005420)5.34312811
5Chronic obstructive pulmonary disease (HP:0006510)5.22035766
6Obstructive lung disease (HP:0006536)5.22035766
7Elevated erythrocyte sedimentation rate (HP:0003565)4.62392670
8Abnormality of macrophages (HP:0004311)4.48316428
9Mediastinal lymphadenopathy (HP:0100721)4.48101731
10Thrombocytosis (HP:0001894)4.47965151
11Myositis (HP:0100614)4.43670318
12Recurrent skin infections (HP:0001581)4.06833883
13Prolonged bleeding time (HP:0003010)3.94421804
14Periodontitis (HP:0000704)3.92870131
15Abnormality of the prostate (HP:0008775)3.90563444
16Vacuolated lymphocytes (HP:0001922)3.88437653
17Gingivitis (HP:0000230)3.85159184
18Abnormal delayed hypersensitivity skin test (HP:0002963)3.63729583
19Meningitis (HP:0001287)3.48201463
20Recurrent fungal infections (HP:0002841)3.47474527
21Stomatitis (HP:0010280)3.45300164
22Orchitis (HP:0100796)3.37378812
23Eosinophilia (HP:0001880)3.23386696
24Papilledema (HP:0001085)3.15904561
25Recurrent viral infections (HP:0004429)3.15686423
26Increased cerebral lipofuscin (HP:0011813)3.13470065
27T lymphocytopenia (HP:0005403)3.13023032
28Retrobulbar optic neuritis (HP:0100654)3.12894834
29Optic neuritis (HP:0100653)3.12894834
30Agnosia (HP:0010524)3.08678979
31Abnormality of T cell number (HP:0011839)3.01496911
32Increased neuronal autofluorescent lipopigment (HP:0002074)3.01265268
33Vasculitis (HP:0002633)3.01002413
34Cellulitis (HP:0100658)3.00437003
35Granulocytopenia (HP:0001913)2.96004069
36Pulmonary infiltrates (HP:0002113)2.93996952
37Episodic fever (HP:0001954)2.92288594
38Abnormality of liposaccharide metabolism (HP:0010968)2.91392204
39Abnormality of glycosphingolipid metabolism (HP:0004343)2.91392204
40Abnormality of glycolipid metabolism (HP:0010969)2.91392204
41Chronic otitis media (HP:0000389)2.90272110
42Disinhibition (HP:0000734)2.88712524
43Petechiae (HP:0000967)2.87977857
44Systemic lupus erythematosus (HP:0002725)2.86274242
45Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.85524265
46Increased IgE level (HP:0003212)2.80946401
47Autoimmune thrombocytopenia (HP:0001973)2.80911866
48Leukocytosis (HP:0001974)2.78695406
49Peritonitis (HP:0002586)2.76342420
50Urticaria (HP:0001025)2.72560077
51Pulmonary embolism (HP:0002204)2.71023750
52Purpura (HP:0000979)2.69631015
53Basal ganglia calcification (HP:0002135)2.67801504
54Chest pain (HP:0100749)2.65944289
55Dysostosis multiplex (HP:0000943)2.64604732
56IgM deficiency (HP:0002850)2.62617431
57Recurrent pneumonia (HP:0006532)2.61167411
58Anorexia (HP:0002039)2.61120908
59Hemoptysis (HP:0002105)2.60507408
60Osteomyelitis (HP:0002754)2.59464859
61Urinary glycosaminoglycan excretion (HP:0003541)2.59172995
62Mucopolysacchariduria (HP:0008155)2.59172995
63Inflammation of the large intestine (HP:0002037)2.57004486
64Reduced antithrombin III activity (HP:0001976)2.54225647
65Abnormality of T cells (HP:0002843)2.53456734
66Abnormal platelet volume (HP:0011876)2.50289677
67Panhypogammaglobulinemia (HP:0003139)2.49804554
68Hypochromic microcytic anemia (HP:0004840)2.49056480
69J-shaped sella turcica (HP:0002680)2.47549496
70Abnormality of polysaccharide metabolism (HP:0011012)2.45750675
71Abnormality of glycosaminoglycan metabolism (HP:0004371)2.45750675
72Abnormality of mucopolysaccharide metabolism (HP:0011020)2.45750675
73Gastrointestinal inflammation (HP:0004386)2.42913608
74Abnormality of the pleura (HP:0002103)2.42404647
75Recurrent cutaneous fungal infections (HP:0011370)2.41312131
76Chronic mucocutaneous candidiasis (HP:0002728)2.41312131
77Chromsome breakage (HP:0040012)2.40566991
78Increased IgM level (HP:0003496)2.40054231
79Abnormality of B cell number (HP:0010975)2.39284607
80B lymphocytopenia (HP:0010976)2.39284607
81Hypergammaglobulinemia (HP:0010702)2.36877950
82Keratoconjunctivitis sicca (HP:0001097)2.35169990
83Hypochromic anemia (HP:0001931)2.34007989
84Sepsis (HP:0100806)2.31128187
85Abnormality of eosinophils (HP:0001879)2.30640350
86Hepatosplenomegaly (HP:0001433)2.30040864
87Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.29886108
88Gangrene (HP:0100758)2.29610179
89Vertigo (HP:0002321)2.26098591
90Pustule (HP:0200039)2.24704513
91Abnormality of T cell physiology (HP:0011840)2.24160103
92Prostate neoplasm (HP:0100787)2.23454244
93Increased serum ferritin (HP:0003281)2.22854579
94Skin ulcer (HP:0200042)2.21331561
95Epistaxis (HP:0000421)2.20617831
96Amaurosis fugax (HP:0100576)2.20355827
97Recurrent lower respiratory tract infections (HP:0002783)2.19566228
98Thoracic kyphosis (HP:0002942)2.19278742
99Interstitial pulmonary disease (HP:0006530)2.18100044
100Colitis (HP:0002583)2.16506107
101Loss of speech (HP:0002371)2.15376311
102Abnormality of the peritoneum (HP:0002585)2.14623986
103Axonal loss (HP:0003447)2.13577089
104Keratoconjunctivitis (HP:0001096)2.11890716
105Chromosomal breakage induced by crosslinking agents (HP:0003221)2.11480615
106Abnormality of iron homeostasis (HP:0011031)2.11204186
107Pulmonary fibrosis (HP:0002206)2.08448317
108Spontaneous hematomas (HP:0007420)2.07097404
109Abnormality of the endocardium (HP:0004306)2.06430825
110Polyneuropathy (HP:0001271)2.04292253
111Thrombophlebitis (HP:0004418)2.01367525
112Acute hepatic failure (HP:0006554)1.99419790
113Abnormality of the thoracic spine (HP:0100711)1.98811162
114Arterial thrombosis (HP:0004420)1.97460734
115Microcytic anemia (HP:0001935)1.97216182
116Poikiloderma (HP:0001029)1.96896419
117Reticulocytopenia (HP:0001896)1.96275559
118Restrictive lung disease (HP:0002091)1.96184846
119Albinism (HP:0001022)1.95951116
120Abnormality of male internal genitalia (HP:0000022)1.94787731
121Cheilitis (HP:0100825)1.94206501
122Duplicated collecting system (HP:0000081)1.93119495
123Gastrointestinal infarctions (HP:0005244)1.92434254
124Glomerulonephritis (HP:0000099)1.92408668
125Skin rash (HP:0000988)1.92131142
126Joint hemorrhage (HP:0005261)1.91000378
127Type I transferrin isoform profile (HP:0003642)1.90876338
128Glomerulopathy (HP:0100820)1.90083865
129Fatigue (HP:0012378)1.89997554
130Neutropenia (HP:0001875)1.89739774
131Poor head control (HP:0002421)1.88770312
132Menorrhagia (HP:0000132)1.87586080
133Agammaglobulinemia (HP:0004432)1.87465355
134Gingival bleeding (HP:0000225)1.86684307
135Encephalitis (HP:0002383)1.86630534
136Amyloidosis (HP:0011034)1.86403486
137Viral hepatitis (HP:0006562)1.86119628
138Increased mean platelet volume (HP:0011877)1.86030119
139Keratitis (HP:0000491)1.85512894
140Polycythemia (HP:0001901)1.84054682
141Acne (HP:0001061)1.83515797

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK44.89870437
2BLK3.31597727
3RIPK43.19724009
4MAP3K142.93050700
5KIT2.80593376
6IRAK32.64920058
7MAP4K12.61627614
8TAOK32.57291863
9TEC2.48724011
10TYK22.20617669
11FES2.14709317
12PRPF4B2.09634321
13BTK2.07888652
14FGR2.02724016
15TBK12.00252113
16PIM21.96426487
17TNK21.93574721
18MAP2K31.83409647
19SYK1.73942873
20ERN11.66636923
21IKBKE1.62302637
22MAP3K31.62048777
23EIF2AK31.58422262
24TXK1.52928691
25MAP3K121.52438914
26CSF1R1.51121358
27STK161.48543248
28ZAP701.43822453
29CLK11.41742155
30TAOK11.38305704
31BRSK21.33880178
32WEE11.32527601
33LYN1.30641699
34CDC71.27652508
35HCK1.23924470
36JAK11.23737048
37KSR21.22691030
38IKBKB1.22171159
39TESK11.21127010
40BUB11.20751162
41JAK31.18665583
42PIM11.17216016
43CSK1.16564414
44MAP3K11.15200333
45TRPM71.14808712
46FLT31.13984182
47CDK191.13938429
48TESK21.10090395
49EIF2AK21.09908972
50IRAK21.07303430
51IRAK11.07076873
52MAP3K61.06315047
53EIF2AK11.05363618
54CAMKK21.03995318
55ITK1.02607970
56ATR1.00263090
57STK40.99478946
58LCK0.96404810
59GRK60.96372391
60SIK30.94082982
61PDK10.92046719
62ABL20.90908109
63NME20.88909649
64MAP3K20.88808803
65ERBB30.87682882
66STK100.86049509
67RPS6KA40.85256099
68YES10.84523872
69NEK20.84307980
70EPHB10.83924736
71VRK10.83778528
72MATK0.81771646
73RPS6KA60.79591552
74PAK40.79245863
75PDPK10.77006475
76CDK40.76606546
77MARK20.76192479
78PRKCD0.76049528
79MAPK40.75901499
80SCYL20.75390110
81RPS6KL10.74764894
82RPS6KC10.74764894
83NEK90.74069224
84TAOK20.71219449
85JAK20.70529942
86GRK70.68933990
87PTK2B0.68003544
88FYN0.66355581
89MAP3K80.63312909
90CDK60.62385361
91DAPK10.60387340
92MAPK120.60380234
93MAPK70.60302215
94CHUK0.59671574
95CCNB10.59362544
96FGFR30.57405014
97RPS6KA20.56676022
98ABL10.56185250
99MAP3K50.55479501
100CDK70.54659422
101MAP2K40.53086903
102RAF10.52355498
103LRRK20.51699175
104PIK3CG0.51080415
105PLK40.50794100
106CDK80.50508658
107TTN0.50048379
108AURKB0.49489488
109SGK30.48844486
110BRSK10.48313651
111BMPR20.47874522
112STK110.47618146
113DYRK1B0.47596017
114KSR10.46998273
115MOS0.46133308
116PRKCQ0.45866082
117PKN20.45173621
118PTK60.45085683
119MAP3K70.43715078
120PBK0.43657252
121MAP3K130.43234108
122SRPK10.42596048
123HIPK20.42288714
124RET0.41820988
125CAMKK10.40229130
126ACVR1B0.39722062
127CDC42BPA0.39496557
128DAPK20.39392475
129PRKD20.38321120
130SGK20.37794513
131EGFR0.37040974
132TGFBR20.35833115
133MAP3K110.35588419
134MAPKAPK20.34987542
135PLK10.34925295
136MAP2K60.32110854
137SIK20.31121355
138WNK10.31110651
139TTK0.29862529
140CHEK20.28460699
141MARK30.27989997
142PRKD10.21589454
143NLK0.21484597
144EPHA30.20192040

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.40934842
2DNA replication_Homo sapiens_hsa030302.80441727
3Glycosaminoglycan degradation_Homo sapiens_hsa005312.67124418
4Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.59564626
5Autoimmune thyroid disease_Homo sapiens_hsa053202.55730009
6Staphylococcus aureus infection_Homo sapiens_hsa051502.51567455
7Other glycan degradation_Homo sapiens_hsa005112.40562461
8Toll-like receptor signaling pathway_Homo sapiens_hsa046202.22671469
9Lysosome_Homo sapiens_hsa041422.21081930
10Osteoclast differentiation_Homo sapiens_hsa043802.19332366
11Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.12003274
12Pertussis_Homo sapiens_hsa051332.11625907
13Legionellosis_Homo sapiens_hsa051342.11371388
14Tuberculosis_Homo sapiens_hsa051522.03715309
15NOD-like receptor signaling pathway_Homo sapiens_hsa046212.02275097
16Phagosome_Homo sapiens_hsa041451.99855860
17NF-kappa B signaling pathway_Homo sapiens_hsa040641.92723820
18RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.90878928
19Homologous recombination_Homo sapiens_hsa034401.84633334
20Base excision repair_Homo sapiens_hsa034101.82703644
21Measles_Homo sapiens_hsa051621.75704721
22Mismatch repair_Homo sapiens_hsa034301.72866614
23Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.72394777
24Antigen processing and presentation_Homo sapiens_hsa046121.70557276
25B cell receptor signaling pathway_Homo sapiens_hsa046621.65116079
26Asthma_Homo sapiens_hsa053101.64675755
27Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.64286677
28Non-homologous end-joining_Homo sapiens_hsa034501.51202214
29Herpes simplex infection_Homo sapiens_hsa051681.50317566
30Influenza A_Homo sapiens_hsa051641.47966182
31Intestinal immune network for IgA production_Homo sapiens_hsa046721.47644403
32Malaria_Homo sapiens_hsa051441.45134243
33Salmonella infection_Homo sapiens_hsa051321.38996134
34Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.37772442
35Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.35511146
36Apoptosis_Homo sapiens_hsa042101.29997220
37Shigellosis_Homo sapiens_hsa051311.29950552
38Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.27177086
39Renin-angiotensin system_Homo sapiens_hsa046141.26839807
40Primary immunodeficiency_Homo sapiens_hsa053401.23324828
41Toxoplasmosis_Homo sapiens_hsa051451.18673139
42Hematopoietic cell lineage_Homo sapiens_hsa046401.16999595
43Pentose phosphate pathway_Homo sapiens_hsa000301.16470010
44Graft-versus-host disease_Homo sapiens_hsa053321.14501668
45N-Glycan biosynthesis_Homo sapiens_hsa005101.07803150
46Allograft rejection_Homo sapiens_hsa053301.06372595
47Hepatitis B_Homo sapiens_hsa051611.05830220
48Leukocyte transendothelial migration_Homo sapiens_hsa046701.05674207
49Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.05583089
50Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.04217844
51Non-small cell lung cancer_Homo sapiens_hsa052231.04158144
52Rheumatoid arthritis_Homo sapiens_hsa053231.02473775
53TNF signaling pathway_Homo sapiens_hsa046681.01487816
54Fanconi anemia pathway_Homo sapiens_hsa034600.99601327
55Chemokine signaling pathway_Homo sapiens_hsa040620.99024120
56Protein export_Homo sapiens_hsa030600.97924180
57Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.96899177
58Nucleotide excision repair_Homo sapiens_hsa034200.93219619
59Jak-STAT signaling pathway_Homo sapiens_hsa046300.84382155
60Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.83694527
61African trypanosomiasis_Homo sapiens_hsa051430.82080906
62Cell cycle_Homo sapiens_hsa041100.78481477
63Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.78256055
64Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.77140648
65Transcriptional misregulation in cancer_Homo sapiens_hsa052020.74977039
66Viral myocarditis_Homo sapiens_hsa054160.73090026
67Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.72085147
68Hepatitis C_Homo sapiens_hsa051600.72075659
69Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.72017813
70VEGF signaling pathway_Homo sapiens_hsa043700.70462209
71Renal cell carcinoma_Homo sapiens_hsa052110.69946493
72p53 signaling pathway_Homo sapiens_hsa041150.69438563
73Galactose metabolism_Homo sapiens_hsa000520.68701749
74Epstein-Barr virus infection_Homo sapiens_hsa051690.67876434
75Pyrimidine metabolism_Homo sapiens_hsa002400.67117631
76Systemic lupus erythematosus_Homo sapiens_hsa053220.66983143
77Caffeine metabolism_Homo sapiens_hsa002320.65439418
78One carbon pool by folate_Homo sapiens_hsa006700.64619036
79Proteasome_Homo sapiens_hsa030500.62605517
80Prolactin signaling pathway_Homo sapiens_hsa049170.62507000
81Platelet activation_Homo sapiens_hsa046110.62218196
82Sphingolipid metabolism_Homo sapiens_hsa006000.61784621
83Acute myeloid leukemia_Homo sapiens_hsa052210.61069246
84Endocytosis_Homo sapiens_hsa041440.61036271
85Pancreatic cancer_Homo sapiens_hsa052120.60933207
86Neurotrophin signaling pathway_Homo sapiens_hsa047220.60721456
87Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.59888071
88Dorso-ventral axis formation_Homo sapiens_hsa043200.56755161
89Phospholipase D signaling pathway_Homo sapiens_hsa040720.56445486
90Ribosome_Homo sapiens_hsa030100.55808529
91Chronic myeloid leukemia_Homo sapiens_hsa052200.53975344
92Regulation of autophagy_Homo sapiens_hsa041400.53682474
93GnRH signaling pathway_Homo sapiens_hsa049120.52596626
94Type I diabetes mellitus_Homo sapiens_hsa049400.52428814
95Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.52105592
96Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.51630915
97FoxO signaling pathway_Homo sapiens_hsa040680.51628093
98Phosphatidylinositol signaling system_Homo sapiens_hsa040700.51445947
99Pentose and glucuronate interconversions_Homo sapiens_hsa000400.49584967
100Adipocytokine signaling pathway_Homo sapiens_hsa049200.49557476
101Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.49214042
102Choline metabolism in cancer_Homo sapiens_hsa052310.48526689
103Starch and sucrose metabolism_Homo sapiens_hsa005000.48311468
104Viral carcinogenesis_Homo sapiens_hsa052030.48150642
105Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.47761097
106HIF-1 signaling pathway_Homo sapiens_hsa040660.47357252
107Amoebiasis_Homo sapiens_hsa051460.46305781
108Spliceosome_Homo sapiens_hsa030400.45380883
109Collecting duct acid secretion_Homo sapiens_hsa049660.44553733
110Notch signaling pathway_Homo sapiens_hsa043300.43616517
111Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.43399913
112HTLV-I infection_Homo sapiens_hsa051660.42109130
113Endometrial cancer_Homo sapiens_hsa052130.41577079
114SNARE interactions in vesicular transport_Homo sapiens_hsa041300.39816038
115Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.39731893
116Type II diabetes mellitus_Homo sapiens_hsa049300.37533449
117mTOR signaling pathway_Homo sapiens_hsa041500.36176625
118Sphingolipid signaling pathway_Homo sapiens_hsa040710.35947756
119Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.35543658
120Carbohydrate digestion and absorption_Homo sapiens_hsa049730.35391281
121Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.35295691
122MAPK signaling pathway_Homo sapiens_hsa040100.34725062
123Small cell lung cancer_Homo sapiens_hsa052220.34592449
124Glutathione metabolism_Homo sapiens_hsa004800.33826448
125T cell receptor signaling pathway_Homo sapiens_hsa046600.33648715
126Inositol phosphate metabolism_Homo sapiens_hsa005620.33093483
127Insulin resistance_Homo sapiens_hsa049310.32965266
128AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.32525294
129Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.32314625
130Regulation of actin cytoskeleton_Homo sapiens_hsa048100.30574653
131Colorectal cancer_Homo sapiens_hsa052100.30072069
132Glycerophospholipid metabolism_Homo sapiens_hsa005640.30014136

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