CLEC16A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the C-type lectin domain containing family. Single nucleotide polymorphisms in introns of this gene have been associated with diabetes mellitus, multiple sclerosis and rheumatoid arthritis. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.16786535
2locomotory exploration behavior (GO:0035641)4.67869153
3synaptic vesicle maturation (GO:0016188)4.48714321
4vocalization behavior (GO:0071625)4.44602690
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.41080599
6cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.39931302
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.39804010
8synaptic vesicle exocytosis (GO:0016079)4.34919527
9synaptic vesicle docking involved in exocytosis (GO:0016081)4.22242137
10cell communication by electrical coupling (GO:0010644)4.11167557
11sodium ion export (GO:0071436)4.10497054
12regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.08506961
13cellular potassium ion homeostasis (GO:0030007)4.06433976
14membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.01246413
15glutamate secretion (GO:0014047)3.98031164
16regulation of synapse structural plasticity (GO:0051823)3.90148085
17regulation of glutamate receptor signaling pathway (GO:1900449)3.89809177
18establishment of protein localization to Golgi (GO:0072600)3.84442319
19regulation of synaptic vesicle exocytosis (GO:2000300)3.77012824
20histone H3-K4 trimethylation (GO:0080182)3.72365348
21layer formation in cerebral cortex (GO:0021819)3.64087979
22retrograde transport, vesicle recycling within Golgi (GO:0000301)3.59650317
23neurotransmitter-gated ion channel clustering (GO:0072578)3.58853943
24positive regulation of synapse maturation (GO:0090129)3.58109111
25protein localization to synapse (GO:0035418)3.57516849
26neurotransmitter secretion (GO:0007269)3.54576119
27ionotropic glutamate receptor signaling pathway (GO:0035235)3.54373091
28regulation of synaptic vesicle transport (GO:1902803)3.52543650
29protein targeting to Golgi (GO:0000042)3.52464351
30positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.38930388
31activation of protein kinase A activity (GO:0034199)3.36903089
32positive regulation of CREB transcription factor activity (GO:0032793)3.36182368
33regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.35474523
34cell communication involved in cardiac conduction (GO:0086065)3.35362124
35exploration behavior (GO:0035640)3.34484600
36regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.33107158
37glutamate receptor signaling pathway (GO:0007215)3.32306471
38regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.27604297
39gamma-aminobutyric acid transport (GO:0015812)3.24983170
40regulation of neuronal synaptic plasticity (GO:0048168)3.24773869
41membrane depolarization during action potential (GO:0086010)3.24563015
42negative regulation of cytosolic calcium ion concentration (GO:0051481)3.23713702
43synaptic vesicle endocytosis (GO:0048488)3.23415309
44regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.21834631
45proline transport (GO:0015824)3.19568589
46regulation of long-term neuronal synaptic plasticity (GO:0048169)3.19288160
47protein K48-linked deubiquitination (GO:0071108)3.18194931
48regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.17932759
49plasma membrane repair (GO:0001778)3.14091361
50synaptic transmission, glutamatergic (GO:0035249)3.14009657
51regulation of membrane repolarization (GO:0060306)3.12235524
52regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.11364394
53neuronal action potential propagation (GO:0019227)3.11260575
54regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.10952997
55positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.09871342
56regulation of ARF protein signal transduction (GO:0032012)3.04404441
57phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.03714864
58regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.02550777
59positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.01458553
60cerebellar Purkinje cell differentiation (GO:0021702)3.00592638
61dendritic spine morphogenesis (GO:0060997)2.99174080
62neuron-neuron synaptic transmission (GO:0007270)2.98887823
63cilium or flagellum-dependent cell motility (GO:0001539)2.98221285
64G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.97813860
65potassium ion import (GO:0010107)2.97776861
66phosphorelay signal transduction system (GO:0000160)2.97119307
67cellular sodium ion homeostasis (GO:0006883)2.96492556
68myoblast fusion (GO:0007520)2.96438520
69long-term memory (GO:0007616)2.96335238
70regulation of excitatory postsynaptic membrane potential (GO:0060079)2.94144141
71negative regulation of potassium ion transmembrane transport (GO:1901380)2.93707802
72neuron cell-cell adhesion (GO:0007158)2.92982398
73protein polyglutamylation (GO:0018095)2.91806657
74positive regulation of potassium ion transmembrane transport (GO:1901381)2.90026882
75regulation of Rab GTPase activity (GO:0032313)2.88296138
76positive regulation of Rab GTPase activity (GO:0032851)2.88296138
77histone H3-K4 methylation (GO:0051568)2.88232413
78potassium ion homeostasis (GO:0055075)2.85684152
79negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.85599119
80regulation of postsynaptic membrane potential (GO:0060078)2.84423936
81regulation of calcium ion transmembrane transporter activity (GO:1901019)2.80312425
82regulation of calcium ion transmembrane transport (GO:1903169)2.80312425
83neurotransmitter transport (GO:0006836)2.79561660
84syncytium formation by plasma membrane fusion (GO:0000768)2.77975211
85dendrite morphogenesis (GO:0048813)2.74062368
86neuromuscular process controlling balance (GO:0050885)2.73447836
87neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.72775610
88cardiac muscle contraction (GO:0060048)2.72614650
89regulation of dendritic spine morphogenesis (GO:0061001)2.72399013
90gamma-aminobutyric acid signaling pathway (GO:0007214)2.70186143
91regulation of synaptic transmission, glutamatergic (GO:0051966)2.70155084
92positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.69516089
93positive regulation of membrane potential (GO:0045838)2.66900882
94regulation of synapse maturation (GO:0090128)2.66423651
95membrane repolarization (GO:0086009)2.66122443
96regulation of synaptic plasticity (GO:0048167)2.64662191
97histone lysine methylation (GO:0034968)2.64311304
98regulation of voltage-gated calcium channel activity (GO:1901385)2.64088043
99cytoplasmic mRNA processing body assembly (GO:0033962)2.63884258
100alanine transport (GO:0032328)2.63860221
101membrane depolarization (GO:0051899)2.63576097
102innervation (GO:0060384)2.62935184
103adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.62216540
104neuromuscular process controlling posture (GO:0050884)2.62062008
105cardiac myofibril assembly (GO:0055003)2.61520495
106regulation of cell communication by electrical coupling (GO:0010649)2.61117428
107glucocorticoid receptor signaling pathway (GO:0042921)2.60417530
108neuronal action potential (GO:0019228)2.59951097
109regulation of neurotransmitter secretion (GO:0046928)2.59715639
110glycine transport (GO:0015816)2.59515470
111regulation of neurotransmitter levels (GO:0001505)2.59083601
112sarcoplasmic reticulum calcium ion transport (GO:0070296)2.59065118
113vesicle transport along microtubule (GO:0047496)2.59064122
114positive regulation of sodium ion transport (GO:0010765)2.58173089
115neuron recognition (GO:0008038)2.58139351
116membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.57763373
117regulation of ion transmembrane transporter activity (GO:0032412)2.57077513
118establishment of nucleus localization (GO:0040023)2.57057428
119negative regulation of cAMP-mediated signaling (GO:0043951)2.56394060
120corticosteroid receptor signaling pathway (GO:0031958)2.56332978
121cardiac conduction (GO:0061337)2.56250976
122auditory behavior (GO:0031223)2.56150143
123prepulse inhibition (GO:0060134)2.56042332
124striatum development (GO:0021756)2.55382819
125lipid translocation (GO:0034204)2.54237375
126phospholipid translocation (GO:0045332)2.54237375
127insulin-like growth factor receptor signaling pathway (GO:0048009)2.53907074
128histone H3-K9 demethylation (GO:0033169)2.52898906
129protein localization to Golgi apparatus (GO:0034067)2.51479525
130cellular response to ethanol (GO:0071361)2.51023764
131musculoskeletal movement (GO:0050881)2.48938695
132multicellular organismal movement (GO:0050879)2.48938695
133syncytium formation (GO:0006949)2.47543133
134sperm motility (GO:0030317)2.46360108
135negative regulation of sodium ion transport (GO:0010766)2.44939734
136histone H3-K36 demethylation (GO:0070544)2.42301372
137Golgi to endosome transport (GO:0006895)2.39409732
138microtubule nucleation (GO:0007020)2.38660379
139regulation of B cell receptor signaling pathway (GO:0050855)2.35491622
140peptidyl-lysine trimethylation (GO:0018023)2.35327173
141interkinetic nuclear migration (GO:0022027)2.34228339
142calcium ion-dependent exocytosis (GO:0017156)2.33869073
143regulation of ARF GTPase activity (GO:0032312)2.33648539
144acrosome reaction (GO:0007340)2.33589735
145peptidyl-lysine methylation (GO:0018022)2.31839764
146striated muscle atrophy (GO:0014891)2.29953086
147negative regulation of calcium ion transport into cytosol (GO:0010523)2.29780803
148ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.26218649
149regulation of establishment of cell polarity (GO:2000114)2.24492690
150regulation of respiratory system process (GO:0044065)2.24158390
151negative regulation of Rho protein signal transduction (GO:0035024)2.23864205
152regulation of female gonad development (GO:2000194)2.23028224
153nerve growth factor signaling pathway (GO:0038180)2.20581356
154primary amino compound metabolic process (GO:1901160)2.18895855
155nucleus localization (GO:0051647)2.18540797
156cellular response to epinephrine stimulus (GO:0071872)2.17205679
157regulation of NFAT protein import into nucleus (GO:0051532)2.16056638
158cellular response to monoamine stimulus (GO:0071868)2.15762806
159cellular response to catecholamine stimulus (GO:0071870)2.15762806
160histone lysine demethylation (GO:0070076)2.15408957
161regulation of gamma-delta T cell differentiation (GO:0045586)2.14585178
162positive regulation of protein deacetylation (GO:0090312)2.13383688
163neuronal ion channel clustering (GO:0045161)2.13152772
164skeletal muscle adaptation (GO:0043501)2.13051703
165histone methylation (GO:0016571)2.12539384
166histone demethylation (GO:0016577)2.12290614
167cAMP catabolic process (GO:0006198)2.12131221
168positive regulation of histone deacetylation (GO:0031065)2.12066280
169chromatin silencing (GO:0006342)2.08595175
170histone H3-K9 methylation (GO:0051567)2.07631013
171histone H3-K9 modification (GO:0061647)2.07101926
172multicellular organism reproduction (GO:0032504)2.06273831
173regulation of respiratory gaseous exchange (GO:0043576)2.06195058
174regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.03627333
175regulation of interleukin-12 biosynthetic process (GO:0045075)2.03501818
176organelle transport along microtubule (GO:0072384)2.00980995
177urinary tract smooth muscle contraction (GO:0014848)1.99957910
178heparin metabolic process (GO:0030202)1.99579384
179heparin biosynthetic process (GO:0030210)1.99579384
180intracellular estrogen receptor signaling pathway (GO:0030520)1.99216067

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.16990694
2GBX2_23144817_ChIP-Seq_PC3_Human2.88452125
3DROSHA_22980978_ChIP-Seq_HELA_Human2.70782178
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.51092399
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.50789102
6RARB_27405468_Chip-Seq_BRAIN_Mouse2.34799486
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.30949345
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.28290146
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.28290146
10REST_21632747_ChIP-Seq_MESCs_Mouse2.22889062
11MTF2_20144788_ChIP-Seq_MESCs_Mouse2.22275657
12SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.17036565
13EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.16637302
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.11916689
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.01120815
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.97178392
17EZH2_27294783_Chip-Seq_ESCs_Mouse1.97008216
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.96501832
19SUZ12_27294783_Chip-Seq_ESCs_Mouse1.91660187
20* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.89916024
21REST_18959480_ChIP-ChIP_MESCs_Mouse1.89403914
22EZH2_27304074_Chip-Seq_ESCs_Mouse1.88596882
23RNF2_27304074_Chip-Seq_ESCs_Mouse1.84606794
24MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.84265039
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.81086215
26BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.79297803
27RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.69481801
28EED_16625203_ChIP-ChIP_MESCs_Mouse1.67179546
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.62669312
30AR_21572438_ChIP-Seq_LNCaP_Human1.51390283
31SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.50639763
32CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.49870948
33RUNX_20019798_ChIP-Seq_JUKART_Human1.49079062
34ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.45905537
35* GATA1_19941827_ChIP-Seq_MEL_Mouse1.44372341
36IKZF1_21737484_ChIP-ChIP_HCT116_Human1.40911081
37TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.40443296
38* SMAD4_21799915_ChIP-Seq_A2780_Human1.38288981
39POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.37248984
40TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37248984
41* KDM2B_26808549_Chip-Seq_K562_Human1.34937417
42ERG_21242973_ChIP-ChIP_JURKAT_Human1.32927243
43PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.31904818
44* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.30738309
45* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.29605430
46SOX2_21211035_ChIP-Seq_LN229_Gbm1.28812569
47AR_19668381_ChIP-Seq_PC3_Human1.27819035
48* GATA1_19941826_ChIP-Seq_K562_Human1.27118244
49EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.26773503
50NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.24708367
51PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.23175972
52ZNF274_21170338_ChIP-Seq_K562_Hela1.23108959
53E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.22240438
54DNAJC2_21179169_ChIP-ChIP_NT2_Human1.21944803
55THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.21605380
56CTBP2_25329375_ChIP-Seq_LNCAP_Human1.21501227
57RING1B_27294783_Chip-Seq_ESCs_Mouse1.20296193
58EP300_21415370_ChIP-Seq_HL-1_Mouse1.19785988
59CTBP1_25329375_ChIP-Seq_LNCAP_Human1.18127407
60ARNT_22903824_ChIP-Seq_MCF-7_Human1.18085925
61AHR_22903824_ChIP-Seq_MCF-7_Human1.17552679
62NR3C1_23031785_ChIP-Seq_PC12_Mouse1.16530190
63GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16046231
64RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.14713029
65NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.13873650
66CDX2_19796622_ChIP-Seq_MESCs_Mouse1.13675649
67* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.13439145
68ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.13186406
69SMAD_19615063_ChIP-ChIP_OVARY_Human1.12654008
70GATA1_22025678_ChIP-Seq_K562_Human1.12645581
71RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.12524399
72* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.12425867
73* SCL_19346495_ChIP-Seq_HPC-7_Human1.12097117
74TP53_16413492_ChIP-PET_HCT116_Human1.09672624
75ESR1_20079471_ChIP-ChIP_T-47D_Human1.09476394
76ZFP281_18757296_ChIP-ChIP_E14_Mouse1.09270115
77ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.08784480
78EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.08565991
79AR_25329375_ChIP-Seq_VCAP_Human1.08334884
80WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.08119957
81* STAT3_23295773_ChIP-Seq_U87_Human1.07179957
82* SMAD3_21741376_ChIP-Seq_HESCs_Human1.06407585
83KDM2B_26808549_Chip-Seq_DND41_Human1.06237262
84SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.05108335
85TP53_23651856_ChIP-Seq_MEFs_Mouse1.03937011
86KDM2B_26808549_Chip-Seq_SUP-B15_Human1.03927194
87VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.03821470
88* SMAD4_21741376_ChIP-Seq_HESCs_Human1.03602806
89KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.03578879
90TCF7_22412390_ChIP-Seq_EML_Mouse1.03409415
91SOX9_24532713_ChIP-Seq_HFSC_Mouse1.02359969
92SPI1_23127762_ChIP-Seq_K562_Human1.01717859
93* PRDM14_20953172_ChIP-Seq_ESCs_Human1.01025702
94VDR_24787735_ChIP-Seq_THP-1_Human1.01019965
95* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00849296
96CTCF_27219007_Chip-Seq_Bcells_Human1.00569951
97TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00049375
98* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.99087215
99VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.98747847
100PIAS1_25552417_ChIP-Seq_VCAP_Human0.97770847
101IRF8_22096565_ChIP-ChIP_GC-B_Human0.97586631
102* SMAD3_21741376_ChIP-Seq_EPCs_Human0.97455411
103TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.96897910
104KDM2B_26808549_Chip-Seq_REH_Human0.96885037
105WDR5_24793694_ChIP-Seq_LNCAP_Human0.96859332
106P53_22127205_ChIP-Seq_FIBROBLAST_Human0.95833255
107SMC4_20622854_ChIP-Seq_HELA_Human0.95449470
108TCF4_23295773_ChIP-Seq_U87_Human0.95355088
109* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95272230
110* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.94832969
111MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93486673
112* CTNNB1_20460455_ChIP-Seq_HCT116_Human0.93382383
113CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.92043074
114BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.91620017
115TP63_22573176_ChIP-Seq_HFKS_Human0.91586648
116TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.91342601
117RING1B_27294783_Chip-Seq_NPCs_Mouse0.90378081
118KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.89951494
119TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88701403
120ELK4_26923725_Chip-Seq_MESODERM_Mouse0.88677989
121GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88440816
122FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.88329222
123PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.88326827
124RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.88017465
125KDM2B_26808549_Chip-Seq_JURKAT_Human0.87130728
126AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.87125649
127OCT1_27270436_Chip-Seq_PROSTATE_Human0.86407616
128LXR_22292898_ChIP-Seq_THP-1_Human0.86374627
129* GATA2_19941826_ChIP-Seq_K562_Human0.85705906
130BCAT_22108803_ChIP-Seq_LS180_Human0.85683657
131ZFP281_27345836_Chip-Seq_ESCs_Mouse0.85668404
132TBX20_22328084_ChIP-Seq_HEART_Mouse0.85423448
133TBX20_22080862_ChIP-Seq_HEART_Mouse0.85423448
134RUNX2_22187159_ChIP-Seq_PCA_Human0.85386513
135TET1_21490601_ChIP-Seq_MESCs_Mouse0.85010955
136* FOXA2_19822575_ChIP-Seq_HepG2_Human0.84875325
137OCT4_19829295_ChIP-Seq_ESCs_Human0.84803335
138RXR_22108803_ChIP-Seq_LS180_Human0.84769824
139TOP2B_26459242_ChIP-Seq_MCF-7_Human0.84388176
140TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.83971955
141SMAD3_21741376_ChIP-Seq_ESCs_Human0.83783395

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.55500554
2MP0002837_dystrophic_cardiac_calcinosis3.42828271
3MP0003635_abnormal_synaptic_transmissio3.41517011
4MP0003646_muscle_fatigue3.17439582
5MP0000751_myopathy3.05706968
6MP0003045_fibrosis2.99664879
7MP0003880_abnormal_central_pattern2.79501373
8MP0002063_abnormal_learning/memory/cond2.72743946
9MP0004270_analgesia2.72307861
10MP0009046_muscle_twitch2.68013069
11MP0009745_abnormal_behavioral_response2.66105619
12MP0002009_preneoplasia2.50770466
13MP0002064_seizures2.45582419
14MP0004215_abnormal_myocardial_fiber2.32768519
15MP0005410_abnormal_fertilization2.22852476
16MP0002909_abnormal_adrenal_gland2.13670653
17MP0009780_abnormal_chondrocyte_physiolo2.13418143
18MP0002572_abnormal_emotion/affect_behav2.10727795
19MP0004130_abnormal_muscle_cell2.08192167
20MP0001984_abnormal_olfaction2.04459132
21MP0002822_catalepsy2.03460106
22MP0004145_abnormal_muscle_electrophysio2.01760539
23MP0001348_abnormal_lacrimal_gland1.98467512
24MP0002272_abnormal_nervous_system1.97971753
25MP0004036_abnormal_muscle_relaxation1.97900505
26MP0003183_abnormal_peptide_metabolism1.95396200
27MP0004084_abnormal_cardiac_muscle1.92477768
28MP0001486_abnormal_startle_reflex1.92354398
29MP0003329_amyloid_beta_deposits1.92246598
30MP0004233_abnormal_muscle_weight1.91691516
31MP0005423_abnormal_somatic_nervous1.90329078
32MP0001968_abnormal_touch/_nociception1.88735828
33MP0002734_abnormal_mechanical_nocicepti1.87132994
34MP0001501_abnormal_sleep_pattern1.84555063
35MP0008569_lethality_at_weaning1.79941857
36MP0004858_abnormal_nervous_system1.76176912
37MP0000749_muscle_degeneration1.73948029
38MP0005409_darkened_coat_color1.66559677
39MP0001440_abnormal_grooming_behavior1.65662507
40MP0002067_abnormal_sensory_capabilities1.58049914
41MP0003172_abnormal_lysosome_physiology1.53389685
42MP0005620_abnormal_muscle_contractility1.49627938
43MP0002735_abnormal_chemical_nociception1.47094660
44MP0004087_abnormal_muscle_fiber1.46784757
45MP0003137_abnormal_impulse_conducting1.46655396
46MP0004924_abnormal_behavior1.45233286
47MP0005386_behavior/neurological_phenoty1.45233286
48MP0002184_abnormal_innervation1.43162106
49MP0005310_abnormal_salivary_gland1.43067860
50MP0003091_abnormal_cell_migration1.41994631
51MP0001986_abnormal_taste_sensitivity1.41978129
52MP0003763_abnormal_thymus_physiology1.41810807
53MP0004085_abnormal_heartbeat1.39236310
54MP0002736_abnormal_nociception_after1.39098271
55MP0004811_abnormal_neuron_physiology1.38505637
56MP0008961_abnormal_basal_metabolism1.37507666
57MP0000569_abnormal_digit_pigmentation1.34980495
58MP0005330_cardiomyopathy1.34908154
59MP0002269_muscular_atrophy1.34646360
60MP0005551_abnormal_eye_electrophysiolog1.33549557
61MP0000015_abnormal_ear_pigmentation1.31587240
62MP0003879_abnormal_hair_cell1.28617824
63MP0000003_abnormal_adipose_tissue1.28346511
64MP0005646_abnormal_pituitary_gland1.27831345
65MP0001970_abnormal_pain_threshold1.27783057
66MP0002733_abnormal_thermal_nociception1.27217094
67MP0002557_abnormal_social/conspecific_i1.26710380
68MP0002168_other_aberrant_phenotype1.25989472
69MP0000427_abnormal_hair_cycle1.25273145
70MP0004043_abnormal_pH_regulation1.24160644
71MP0004510_myositis1.23561731
72MP0004484_altered_response_of1.23085716
73MP0000747_muscle_weakness1.22851847
74MP0001502_abnormal_circadian_rhythm1.22311303
75MP0003633_abnormal_nervous_system1.21860194
76MP0005451_abnormal_body_composition1.21825650
77MP0002972_abnormal_cardiac_muscle1.21196880
78MP0004381_abnormal_hair_follicle1.20572578
79MP0004885_abnormal_endolymph1.18147548
80MP0002106_abnormal_muscle_physiology1.16926400
81MP0002066_abnormal_motor_capabilities/c1.16038947
82MP0000778_abnormal_nervous_system1.15727364
83MP0000955_abnormal_spinal_cord1.15660099
84MP0005670_abnormal_white_adipose1.15083511
85MP0003698_abnormal_male_reproductive1.12885562
86MP0000759_abnormal_skeletal_muscle1.11108485
87MP0002882_abnormal_neuron_morphology1.11086147
88MP0000685_abnormal_immune_system1.10219533
89MP0003787_abnormal_imprinting1.08993751
90MP0009278_abnormal_bone_marrow1.07977744
91MP0002090_abnormal_vision1.06364644
92MP0005535_abnormal_body_temperature1.06273846
93MP0008775_abnormal_heart_ventricle1.03514703
94MP0004742_abnormal_vestibular_system1.03328876
95MP0003631_nervous_system_phenotype1.02605350
96MP0003959_abnormal_lean_body1.00635880
97MP0005076_abnormal_cell_differentiation1.00347682
98MP0008877_abnormal_DNA_methylation0.99846719
99MP0009115_abnormal_fat_cell0.98893299
100MP0000604_amyloidosis0.98128555
101MP0005369_muscle_phenotype0.97039758
102MP0003300_gastrointestinal_ulcer0.95392713
103MP0008874_decreased_physiological_sensi0.92121049
104MP0002138_abnormal_hepatobiliary_system0.92067849
105MP0002229_neurodegeneration0.91482172
106MP0003303_peritoneal_inflammation0.88992448
107MP0004142_abnormal_muscle_tone0.88093322
108MP0000750_abnormal_muscle_regeneration0.87434521
109MP0005385_cardiovascular_system_phenoty0.86686591
110MP0001544_abnormal_cardiovascular_syste0.86686591
111MP0006138_congestive_heart_failure0.85367019
112MP0002332_abnormal_exercise_endurance0.84807381
113MP0000013_abnormal_adipose_tissue0.84674573
114MP0002152_abnormal_brain_morphology0.84054748
115MP0000920_abnormal_myelination0.83923986
116MP0002234_abnormal_pharynx_morphology0.83058202
117MP0002069_abnormal_eating/drinking_beha0.82066425
118MP0005623_abnormal_meninges_morphology0.81801112
119MP0001800_abnormal_humoral_immune0.81694743
120MP0003075_altered_response_to0.81098297
121MP0010630_abnormal_cardiac_muscle0.78968969
122MP0006276_abnormal_autonomic_nervous0.77994741
123MP0005666_abnormal_adipose_tissue0.77528999
124MP0001790_abnormal_immune_system0.76098285
125MP0005387_immune_system_phenotype0.76098285
126MP0003690_abnormal_glial_cell0.75489023
127MP0008872_abnormal_physiological_respon0.75451490
128MP0004134_abnormal_chest_morphology0.75310020
129MP0005645_abnormal_hypothalamus_physiol0.74689669
130MP0000383_abnormal_hair_follicle0.74324446
131MP0003632_abnormal_nervous_system0.74269163
132MP0005167_abnormal_blood-brain_barrier0.73197259
133MP0000733_abnormal_muscle_development0.71421465
134MP0002876_abnormal_thyroid_physiology0.70224964
135MP0000371_diluted_coat_color0.70169460
136MP0001664_abnormal_digestion0.69706484
137MP0001177_atelectasis0.67304445
138MP0005375_adipose_tissue_phenotype0.67044598
139MP0005187_abnormal_penis_morphology0.66849981
140MP0002166_altered_tumor_susceptibility0.66533156

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.15407539
2Myokymia (HP:0002411)4.55479924
3Exercise-induced myalgia (HP:0003738)4.36006989
4Focal seizures (HP:0007359)4.17648595
5Sudden death (HP:0001699)3.98937580
6Visual hallucinations (HP:0002367)3.85127869
7Epileptic encephalopathy (HP:0200134)3.53736003
8Bundle branch block (HP:0011710)3.47806776
9Dysmetric saccades (HP:0000641)3.42754002
10Febrile seizures (HP:0002373)3.42374736
11Ventricular fibrillation (HP:0001663)3.41986803
12Hypoplastic ischia (HP:0003175)3.41596793
13Action tremor (HP:0002345)3.32081295
14Progressive cerebellar ataxia (HP:0002073)3.30694088
15Exercise-induced muscle cramps (HP:0003710)3.25908849
16Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.20193206
17Absence seizures (HP:0002121)3.17020075
18Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.11186696
19Syncope (HP:0001279)3.09181078
20Dysdiadochokinesis (HP:0002075)3.04368229
21Generalized tonic-clonic seizures (HP:0002069)2.99726783
22Abnormality of the ischium (HP:0003174)2.97080979
23Postural instability (HP:0002172)2.96355057
24Supranuclear gaze palsy (HP:0000605)2.95616380
25Atonic seizures (HP:0010819)2.94760814
26Abnormal social behavior (HP:0012433)2.94364579
27Impaired social interactions (HP:0000735)2.94364579
28Central scotoma (HP:0000603)2.93650395
29Abnormality of the lower motor neuron (HP:0002366)2.93436364
30Atrial fibrillation (HP:0005110)2.91674672
31Calf muscle hypertrophy (HP:0008981)2.87183650
32Difficulty running (HP:0009046)2.86055175
33Prolonged QT interval (HP:0001657)2.85823323
34Primary atrial arrhythmia (HP:0001692)2.82693326
35Muscle hypertrophy of the lower extremities (HP:0008968)2.81994277
36Poor eye contact (HP:0000817)2.81411080
37Truncal obesity (HP:0001956)2.81320991
38Abnormality of the fingertips (HP:0001211)2.75641314
39Dialeptic seizures (HP:0011146)2.71145287
40Urinary bladder sphincter dysfunction (HP:0002839)2.67553327
41Hemiplegia (HP:0002301)2.66955325
42Myoglobinuria (HP:0002913)2.66936140
43Hyporeflexia of lower limbs (HP:0002600)2.66371268
44Depression (HP:0000716)2.66115014
45Supraventricular tachycardia (HP:0004755)2.63420590
46Genetic anticipation (HP:0003743)2.61914922
47Abnormality of the calf musculature (HP:0001430)2.61630941
48Supraventricular arrhythmia (HP:0005115)2.57019253
49Impaired vibration sensation in the lower limbs (HP:0002166)2.56365995
50Clumsiness (HP:0002312)2.55515174
51Broad-based gait (HP:0002136)2.53475924
52Protruding tongue (HP:0010808)2.53411745
53Tapered finger (HP:0001182)2.52926033
54Heart block (HP:0012722)2.52302763
55Gaze-evoked nystagmus (HP:0000640)2.50608661
56Hyperventilation (HP:0002883)2.48377003
57Abnormal EKG (HP:0003115)2.47710285
58Absent speech (HP:0001344)2.44813283
59Myotonia (HP:0002486)2.43195169
60Ventricular arrhythmia (HP:0004308)2.42824500
61Dysmetria (HP:0001310)2.38966639
62Anxiety (HP:0000739)2.38213639
63Diplopia (HP:0000651)2.36779089
64Abnormality of binocular vision (HP:0011514)2.36779089
65EMG: myopathic abnormalities (HP:0003458)2.35457193
66Ankle clonus (HP:0011448)2.33019130
67Truncal ataxia (HP:0002078)2.32859450
68Abnormality of the sella turcica (HP:0002679)2.32748522
69Muscle fiber splitting (HP:0003555)2.31096285
70Status epilepticus (HP:0002133)2.30104203
71Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.29568079
72Thick eyebrow (HP:0000574)2.29353985
73Abnormal atrioventricular conduction (HP:0005150)2.29013509
74Atrioventricular block (HP:0001678)2.24530481
75Inability to walk (HP:0002540)2.24122550
76Urinary urgency (HP:0000012)2.21526105
77Ventricular tachycardia (HP:0004756)2.18631957
78Neoplasm of the heart (HP:0100544)2.18541391
79Deeply set eye (HP:0000490)2.17021255
80Cerebral inclusion bodies (HP:0100314)2.16019166
81Epileptiform EEG discharges (HP:0011182)2.15021826
82Impaired smooth pursuit (HP:0007772)2.14773888
83Onion bulb formation (HP:0003383)2.14361766
84Fair hair (HP:0002286)2.13052400
85Torticollis (HP:0000473)2.12672774
86Asymmetric septal hypertrophy (HP:0001670)2.12379022
87Increased variability in muscle fiber diameter (HP:0003557)2.12328425
88EEG with generalized epileptiform discharges (HP:0011198)2.10189978
89Broad face (HP:0000283)2.09367207
90Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.07825958
91Lower limb amyotrophy (HP:0007210)2.07693442
92Hemiparesis (HP:0001269)2.06168106
93Generalized hypopigmentation of hair (HP:0011358)2.03283903
94Excessive salivation (HP:0003781)2.02859316
95Drooling (HP:0002307)2.02859316
96Heterotopia (HP:0002282)2.02352446
97Intention tremor (HP:0002080)2.01905963
98Colitis (HP:0002583)2.01765996
99Bradykinesia (HP:0002067)2.00736459
100Difficulty climbing stairs (HP:0003551)2.00470112
101Neurofibrillary tangles (HP:0002185)2.00350426
102Hyperkalemia (HP:0002153)2.00076562
103Abnormal eating behavior (HP:0100738)1.99816641
104Supernumerary nipples (HP:0002558)1.99466064
105Long eyelashes (HP:0000527)1.99318366
106Rapidly progressive (HP:0003678)1.98311692
107Thick nail (HP:0001805)1.96433392
108Type 1 muscle fiber predominance (HP:0003803)1.96248762
109Pheochromocytoma (HP:0002666)1.95623210
110Increased connective tissue (HP:0009025)1.93693176
111Hypsarrhythmia (HP:0002521)1.93039899
112Progressive inability to walk (HP:0002505)1.90827238
113Abnormality of ocular smooth pursuit (HP:0000617)1.90799005
114EMG: neuropathic changes (HP:0003445)1.90344070
115Stereotypic behavior (HP:0000733)1.90135565
116Blue irides (HP:0000635)1.90049268
117Left ventricular hypertrophy (HP:0001712)1.89294522
118Partial agenesis of the corpus callosum (HP:0001338)1.88970942
119Lower limb muscle weakness (HP:0007340)1.88281798
120Widely spaced teeth (HP:0000687)1.88067980
121Impaired vibratory sensation (HP:0002495)1.87715316
122Decreased motor nerve conduction velocity (HP:0003431)1.87635810
123Amblyopia (HP:0000646)1.87596666
124Mutism (HP:0002300)1.86927592
125Focal dystonia (HP:0004373)1.86312170
126Abnormality of the left ventricular outflow tract (HP:0011103)1.85320716
127Subaortic stenosis (HP:0001682)1.85320716
128Right ventricular cardiomyopathy (HP:0011663)1.83864094
129Abnormality of the pubic bones (HP:0003172)1.83332781
130Ketoacidosis (HP:0001993)1.81687335
131Athetosis (HP:0002305)1.81648626
132Frequent falls (HP:0002359)1.80966828
133Scotoma (HP:0000575)1.80495247
134Abnormality of the nasal septum (HP:0000419)1.77437667
135Increased number of teeth (HP:0011069)1.76479789
136Hypoplasia of the thymus (HP:0000778)1.76322026
137Relative macrocephaly (HP:0004482)1.76162872
138Resting tremor (HP:0002322)1.76041221
139Increased neuronal autofluorescent lipopigment (HP:0002074)1.75548591
140Scanning speech (HP:0002168)1.74968616
141Tented upper lip vermilion (HP:0010804)1.73134610
142Agammaglobulinemia (HP:0004432)1.73010379
143Submucous cleft hard palate (HP:0000176)1.69877181
144Narrow palate (HP:0000189)1.69735118
145Self-mutilation (HP:0000742)1.67218954
146Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.65936398
147Sandal gap (HP:0001852)1.64889959
148Persistence of primary teeth (HP:0006335)1.63647956
149Obstructive sleep apnea (HP:0002870)1.63327680
150Peripheral hypomyelination (HP:0007182)1.62525704
151Type II lissencephaly (HP:0007260)1.62522601
152Intellectual disability, severe (HP:0010864)1.62297166
153Macroorchidism (HP:0000053)1.61678297
154Slender build (HP:0001533)1.61555828
155Overgrowth (HP:0001548)1.61289891
156Renovascular hypertension (HP:0100817)1.61150413
157Sporadic (HP:0003745)1.60952722
158Curly hair (HP:0002212)1.59559525
159Dislocated radial head (HP:0003083)1.59481864
160Chronic hepatic failure (HP:0100626)1.58105992
161Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.57924548
162Abnormality of the radial head (HP:0003995)1.57363281
163Autism (HP:0000717)1.56159073
164Tubular atrophy (HP:0000092)1.55207355
165Round face (HP:0000311)1.53089980
166Prominent supraorbital ridges (HP:0000336)1.51829984
167Lissencephaly (HP:0001339)1.51386831
168Accelerated skeletal maturation (HP:0005616)1.50853297
169Open mouth (HP:0000194)1.50206720
170Abnormality of the periventricular white matter (HP:0002518)1.48372481
171Increased cerebral lipofuscin (HP:0011813)1.48050673
172Coarse hair (HP:0002208)1.47286709
173Steppage gait (HP:0003376)1.46516937
174Agitation (HP:0000713)1.45298379
175Hepatitis (HP:0012115)1.44142399
176Prominent nose (HP:0000448)1.43933866
177Bowel incontinence (HP:0002607)1.43027178

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.31596671
2CDK123.25865572
3MAP3K93.17401298
4FRK3.10361352
5EPHA43.01622880
6MAP3K42.72743238
7PHKG22.58447585
8PHKG12.58447585
9MARK12.55102336
10EEF2K2.49237988
11PAK62.24338535
12DAPK22.16571618
13PRKD31.99686074
14MINK11.97273879
15STK381.90672998
16LMTK21.88921648
17NTRK21.86712128
18MAP2K41.84095387
19KSR21.71738166
20BRD41.64939581
21RIPK11.62400565
22MAP2K71.60776330
23TRIB31.60076241
24TTN1.57698943
25DMPK1.50893865
26CAMKK11.42462760
27NEK11.40425092
28PDK31.39956510
29PDK41.39956510
30PINK11.37506505
31CAMK1G1.35760851
32MAP3K71.33587884
33TAOK31.29067501
34KSR11.28525226
35RIPK41.26131976
36TAOK11.24090869
37STK241.21214795
38CDK51.20616156
39SIK21.19234110
40TRPM71.18133559
41MAPK111.16501290
42OBSCN1.15255313
43LATS21.15239805
44CHUK1.13526737
45NTRK11.13129964
46EPHA31.12691549
47SGK31.12676197
48TYRO31.05600792
49DAPK11.02502176
50ICK1.01033825
51MAP3K131.00673214
52PAK30.99839373
53SGK20.99694176
54AKT30.96234166
55PRKAA20.96076077
56PRKCG0.94158199
57PRKCH0.93942642
58MAPKAPK30.92813756
59CSF1R0.92751935
60SGK4940.92745248
61SGK2230.92745248
62MAP4K10.92369911
63STK110.92318762
64PRPF4B0.92257898
65MTOR0.91905108
66CAMK1D0.90643251
67CAMK10.87484121
68CAMK2A0.87268386
69MAP3K140.87240279
70PRKD20.86687179
71JAK10.86682078
72MAPK120.85294196
73MARK20.84745460
74BLK0.80880616
75PRKAA10.80556209
76SGK10.80291362
77PTK2B0.79545880
78PKN20.79489046
79RET0.79051688
80RPS6KA60.74371116
81MAP3K60.71880241
82FES0.70843975
83GRK50.70832153
84WNK10.70810157
85FGFR40.70716696
86FGFR30.70629574
87PDK10.70590593
88CDC42BPA0.67606182
89MAP3K20.67296270
90GRK70.66370983
91SYK0.65546241
92PLK20.65297130
93NME10.65205385
94HCK0.64489204
95IRAK10.64347817
96CAMK2D0.64132565
97PDPK10.64049059
98MAP3K10.63844019
99CAMK40.63199880
100MELK0.62281465
101RPS6KA30.60881705
102MAPK130.60311093
103DYRK1A0.59741083
104SIK10.59372757
105ADRBK10.58786742
106PNCK0.58062663
107ROCK10.55800049
108MAPK70.55377962
109PDK20.53794389
110PIK3CG0.52895350
111TAOK20.52866252
112EPHB10.52772670
113MUSK0.52415668
114PDGFRA0.52108467
115DDR20.51440757
116PRKCQ0.51098667
117RPS6KC10.50885137
118RPS6KL10.50885137
119PRKCZ0.50822820
120TNK20.50243508
121ERN10.49371343
122CAMKK20.49348345
123CDK150.47629763
124MAP3K120.47356345
125CDK180.47185446
126BMPR1B0.46914766
127ALK0.46878256
128CAMK2G0.46857524
129UHMK10.46592498
130CDK90.45816010
131BTK0.45532468
132INSRR0.45258057
133IKBKE0.45144936
134MAPK100.44698466
135NEK90.44422361
136JAK30.44314343
137PRKACG0.44272728
138RPS6KA20.43324049
139CASK0.43123364
140PRKD10.42643973
141PIK3CA0.42118541
142CAMK2B0.41946468
143MAPK80.41514216
144FGFR20.41312645

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.72898551
2Synaptic vesicle cycle_Homo sapiens_hsa047212.48762532
3Olfactory transduction_Homo sapiens_hsa047402.39888510
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.24347769
5Circadian entrainment_Homo sapiens_hsa047132.23147278
6GABAergic synapse_Homo sapiens_hsa047272.21242942
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.08763617
8Morphine addiction_Homo sapiens_hsa050321.98375121
9Glutamatergic synapse_Homo sapiens_hsa047241.96624708
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.91559986
11Long-term potentiation_Homo sapiens_hsa047201.88249289
12Salivary secretion_Homo sapiens_hsa049701.78743630
13Insulin secretion_Homo sapiens_hsa049111.76337278
14Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.76307727
15Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.69962407
16Amphetamine addiction_Homo sapiens_hsa050311.61066672
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.60223054
18Nitrogen metabolism_Homo sapiens_hsa009101.59117037
19Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.57453916
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.57111427
21Gastric acid secretion_Homo sapiens_hsa049711.57073307
22Dilated cardiomyopathy_Homo sapiens_hsa054141.55181891
23Dopaminergic synapse_Homo sapiens_hsa047281.54929730
24Renin secretion_Homo sapiens_hsa049241.50378676
25Oxytocin signaling pathway_Homo sapiens_hsa049211.49323509
26Cholinergic synapse_Homo sapiens_hsa047251.49218899
27Type II diabetes mellitus_Homo sapiens_hsa049301.44905086
28Calcium signaling pathway_Homo sapiens_hsa040201.44837709
29Cardiac muscle contraction_Homo sapiens_hsa042601.44816539
30B cell receptor signaling pathway_Homo sapiens_hsa046621.44296882
31Taste transduction_Homo sapiens_hsa047421.38817152
32Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.31654628
33ABC transporters_Homo sapiens_hsa020101.23826969
34Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.20638196
35Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.17538690
36GnRH signaling pathway_Homo sapiens_hsa049121.17496431
37cGMP-PKG signaling pathway_Homo sapiens_hsa040221.15399254
38cAMP signaling pathway_Homo sapiens_hsa040241.12387858
39Acute myeloid leukemia_Homo sapiens_hsa052211.12262326
40Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.11105540
41Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.10520319
42Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.10367290
43Long-term depression_Homo sapiens_hsa047301.02862851
44Glucagon signaling pathway_Homo sapiens_hsa049221.02582786
45Arginine biosynthesis_Homo sapiens_hsa002201.01560596
46Serotonergic synapse_Homo sapiens_hsa047261.00477372
47Phosphatidylinositol signaling system_Homo sapiens_hsa040701.00390215
48Bile secretion_Homo sapiens_hsa049760.99594553
49Sphingolipid signaling pathway_Homo sapiens_hsa040710.98729461
50Cocaine addiction_Homo sapiens_hsa050300.97329509
51T cell receptor signaling pathway_Homo sapiens_hsa046600.96424057
52Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.95934464
53Gap junction_Homo sapiens_hsa045400.94586327
54Platelet activation_Homo sapiens_hsa046110.94397822
55Propanoate metabolism_Homo sapiens_hsa006400.92813149
56Prolactin signaling pathway_Homo sapiens_hsa049170.92646276
57Estrogen signaling pathway_Homo sapiens_hsa049150.91500318
58Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.89230758
59Fatty acid biosynthesis_Homo sapiens_hsa000610.88954300
60Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.87888021
61Butanoate metabolism_Homo sapiens_hsa006500.87839121
62Glioma_Homo sapiens_hsa052140.86905946
63Intestinal immune network for IgA production_Homo sapiens_hsa046720.85544539
64Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.85419994
65Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.84102059
66Vascular smooth muscle contraction_Homo sapiens_hsa042700.83591998
67Fatty acid metabolism_Homo sapiens_hsa012120.80866803
68Carbohydrate digestion and absorption_Homo sapiens_hsa049730.80481942
69Circadian rhythm_Homo sapiens_hsa047100.77696961
70Fatty acid degradation_Homo sapiens_hsa000710.77538730
71Insulin signaling pathway_Homo sapiens_hsa049100.77369835
72Thyroid hormone signaling pathway_Homo sapiens_hsa049190.77041680
73Renal cell carcinoma_Homo sapiens_hsa052110.76836446
74mTOR signaling pathway_Homo sapiens_hsa041500.75558590
75Dorso-ventral axis formation_Homo sapiens_hsa043200.72231482
76Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.72060548
77Chronic myeloid leukemia_Homo sapiens_hsa052200.71962307
78Toxoplasmosis_Homo sapiens_hsa051450.71895233
79FoxO signaling pathway_Homo sapiens_hsa040680.70278221
80Longevity regulating pathway - mammal_Homo sapiens_hsa042110.69701561
81Collecting duct acid secretion_Homo sapiens_hsa049660.68928821
82Pancreatic secretion_Homo sapiens_hsa049720.68117478
83ErbB signaling pathway_Homo sapiens_hsa040120.67126128
84AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.66744078
85Jak-STAT signaling pathway_Homo sapiens_hsa046300.65758445
86Thyroid hormone synthesis_Homo sapiens_hsa049180.64709154
87Melanogenesis_Homo sapiens_hsa049160.64512584
88Osteoclast differentiation_Homo sapiens_hsa043800.64370886
89PPAR signaling pathway_Homo sapiens_hsa033200.63628200
90Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.63506465
91Phototransduction_Homo sapiens_hsa047440.63052045
92Phospholipase D signaling pathway_Homo sapiens_hsa040720.62992278
93Axon guidance_Homo sapiens_hsa043600.62320353
94Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.62307529
95Carbon metabolism_Homo sapiens_hsa012000.62159277
96Hepatitis C_Homo sapiens_hsa051600.62038968
97Pyruvate metabolism_Homo sapiens_hsa006200.61874755
98Pancreatic cancer_Homo sapiens_hsa052120.61823794
99Insulin resistance_Homo sapiens_hsa049310.60436218
100TNF signaling pathway_Homo sapiens_hsa046680.59125512
101Ras signaling pathway_Homo sapiens_hsa040140.59119690
102AMPK signaling pathway_Homo sapiens_hsa041520.58982679
103Chemokine signaling pathway_Homo sapiens_hsa040620.57683864
104Adipocytokine signaling pathway_Homo sapiens_hsa049200.56600208
105VEGF signaling pathway_Homo sapiens_hsa043700.54780203
106Endocytosis_Homo sapiens_hsa041440.54498200
107Sphingolipid metabolism_Homo sapiens_hsa006000.54281604
108MAPK signaling pathway_Homo sapiens_hsa040100.53654008
109Prostate cancer_Homo sapiens_hsa052150.53622860
110Inositol phosphate metabolism_Homo sapiens_hsa005620.52704783
111Focal adhesion_Homo sapiens_hsa045100.51550923
112Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.51102956
113Central carbon metabolism in cancer_Homo sapiens_hsa052300.50720989
114Choline metabolism in cancer_Homo sapiens_hsa052310.49967708
115Tuberculosis_Homo sapiens_hsa051520.49533916
116Influenza A_Homo sapiens_hsa051640.49441990
117Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.49104761
118Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.47905057
119Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.46729342
120Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.45353358
121Lysine degradation_Homo sapiens_hsa003100.43975556
122Neurotrophin signaling pathway_Homo sapiens_hsa047220.42930846
123Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.42748363
124Primary bile acid biosynthesis_Homo sapiens_hsa001200.41027722
125Endometrial cancer_Homo sapiens_hsa052130.40450132
126Biosynthesis of amino acids_Homo sapiens_hsa012300.40031283
127Rap1 signaling pathway_Homo sapiens_hsa040150.38637946
128Oocyte meiosis_Homo sapiens_hsa041140.36958308
129Ovarian steroidogenesis_Homo sapiens_hsa049130.34972699
130Non-small cell lung cancer_Homo sapiens_hsa052230.34321140
131Glycerophospholipid metabolism_Homo sapiens_hsa005640.34182122

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