CLEC17A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of B cell receptor signaling pathway (GO:0050855)7.42614348
2B cell receptor signaling pathway (GO:0050853)6.76592599
3positive regulation of gamma-delta T cell activation (GO:0046645)5.80842664
4modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.62137959
5positive regulation by organism of defense response of other organism involved in symbiotic interact5.62137959
6modulation by symbiont of host immune response (GO:0052553)5.62137959
7positive regulation by symbiont of host defense response (GO:0052509)5.62137959
8modulation by symbiont of host defense response (GO:0052031)5.62137959
9modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.62137959
10antigen processing and presentation of endogenous antigen (GO:0019883)5.33080466
11immunoglobulin mediated immune response (GO:0016064)5.30883435
12regulation of interferon-beta biosynthetic process (GO:0045357)5.11201412
13regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)5.00290814
14regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.94211411
15antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.92526583
16CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)4.86746569
17antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.69647529
18positive regulation of interferon-gamma biosynthetic process (GO:0045078)4.54913668
19B cell proliferation (GO:0042100)4.51238553
20B cell homeostasis (GO:0001782)4.50649727
21antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.50268558
22regulation of B cell differentiation (GO:0045577)4.48340721
23positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.40852833
24negative regulation of cell killing (GO:0031342)4.38449842
25negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.38449842
26positive regulation of B cell differentiation (GO:0045579)4.35642979
27interferon-gamma-mediated signaling pathway (GO:0060333)4.35152923
28B cell mediated immunity (GO:0019724)4.34857800
29macrophage activation involved in immune response (GO:0002281)4.34340094
30regulation of gamma-delta T cell activation (GO:0046643)4.32473383
31positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.22015913
32negative thymic T cell selection (GO:0045060)4.20701100
33NIK/NF-kappaB signaling (GO:0038061)4.18915754
34T cell migration (GO:0072678)4.15035762
35positive thymic T cell selection (GO:0045059)4.12999930
36detection of bacterium (GO:0016045)4.12939105
37defense response to protozoan (GO:0042832)4.08471410
38cellular response to type I interferon (GO:0071357)4.03954891
39type I interferon signaling pathway (GO:0060337)4.03954891
40response to type I interferon (GO:0034340)4.02558159
41cellular response to interleukin-15 (GO:0071350)3.96962700
42negative T cell selection (GO:0043383)3.96644307
43regulation of antigen processing and presentation (GO:0002577)3.96378674
44detection of other organism (GO:0098543)3.94240765
45negative regulation of B cell proliferation (GO:0030889)3.93813822
46regulation of interferon-gamma biosynthetic process (GO:0045072)3.92093887
47T-helper 1 type immune response (GO:0042088)3.89188020
48response to host immune response (GO:0052572)3.88452832
49response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.88452832
50positive regulation of interferon-alpha production (GO:0032727)3.85349512
51positive regulation of humoral immune response (GO:0002922)3.82392040
52regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.77550614
53response to protozoan (GO:0001562)3.75092601
54regulation of alpha-beta T cell proliferation (GO:0046640)3.73117788
55regulation of B cell proliferation (GO:0030888)3.71204533
56positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.69706019
57response to interleukin-15 (GO:0070672)3.69027102
58regulation of interferon-alpha production (GO:0032647)3.62585494
59antigen receptor-mediated signaling pathway (GO:0050851)3.59485417
60regulation of dendritic cell antigen processing and presentation (GO:0002604)3.57930405
61positive T cell selection (GO:0043368)3.54452852
62thymic T cell selection (GO:0045061)3.54289424
63regulation of gamma-delta T cell differentiation (GO:0045586)3.46474116
64T cell costimulation (GO:0031295)3.44390543
65cytidine metabolic process (GO:0046087)3.44090880
66cytidine catabolic process (GO:0006216)3.44090880
67cytidine deamination (GO:0009972)3.44090880
68response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.43435654
69response to host (GO:0075136)3.43435654
70response to host defenses (GO:0052200)3.43435654
71positive regulation of B cell proliferation (GO:0030890)3.40190032
72lymphocyte costimulation (GO:0031294)3.39305689
73T cell lineage commitment (GO:0002360)3.38144950
74germinal center formation (GO:0002467)3.33069269
75T cell selection (GO:0045058)3.32969676
76regulation of germinal center formation (GO:0002634)3.24796482
77positive regulation of B cell activation (GO:0050871)3.24257260
78lymphocyte homeostasis (GO:0002260)3.23253662
79negative regulation of phagocytosis (GO:0050765)3.21574023
80negative regulation of alpha-beta T cell activation (GO:0046636)3.19814974
81negative regulation of lymphocyte mediated immunity (GO:0002707)3.18808933
82regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.18804512
83cellular response to interferon-gamma (GO:0071346)3.16725426
84pyrimidine ribonucleoside catabolic process (GO:0046133)3.15623347
85positive regulation of antigen processing and presentation (GO:0002579)3.14913218
86detection of external biotic stimulus (GO:0098581)3.14319878
87microglial cell activation (GO:0001774)3.12970175
88positive regulation of B cell mediated immunity (GO:0002714)3.09237756
89positive regulation of immunoglobulin mediated immune response (GO:0002891)3.09237756
90regulation of B cell activation (GO:0050864)3.09096163
91positive regulation of alpha-beta T cell proliferation (GO:0046641)3.06533813
92adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli3.03972347
93negative regulation of calcium ion transport into cytosol (GO:0010523)3.01559142
94negative regulation of T cell mediated immunity (GO:0002710)2.98022130
95positive regulation of interferon-beta production (GO:0032728)2.98012099
96regulation of B cell apoptotic process (GO:0002902)2.97822999
97positive regulation of cytokine biosynthetic process (GO:0042108)2.96347388
98positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.91428151
99mature B cell differentiation (GO:0002335)2.89492055
100regulation of interferon-beta production (GO:0032648)2.87149083

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human7.78648141
2IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.52355530
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.33115449
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.07498287
5MYC_22102868_ChIP-Seq_BL_Human3.95219285
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.90111815
7SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.77060359
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.57128970
9E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human3.15276989
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.12128476
11MYB_26560356_Chip-Seq_TH2_Human2.95778358
12VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.90621202
13NOTCH1_21737748_ChIP-Seq_TLL_Human2.80698710
14CIITA_25753668_ChIP-Seq_RAJI_Human2.78527856
15BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.73867659
16IRF8_27001747_Chip-Seq_BMDM_Mouse2.68295284
17FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.66164324
18RUNX_20019798_ChIP-Seq_JUKART_Human2.62772864
19MYB_26560356_Chip-Seq_TH1_Human2.57261954
20SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.40784627
21MAF_26560356_Chip-Seq_TH1_Human2.40507403
22SPI1_23547873_ChIP-Seq_NB4_Human2.35276790
23STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.24843204
24STAT4_19710469_ChIP-ChIP_TH1__Mouse2.15447371
25GATA1_22025678_ChIP-Seq_K562_Human2.11915440
26FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.11634661
27ELF1_17652178_ChIP-ChIP_JURKAT_Human2.11000454
28VDR_21846776_ChIP-Seq_THP-1_Human2.01319899
29GATA3_27048872_Chip-Seq_THYMUS_Human1.99924906
30SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.95911798
31SCL_19346495_ChIP-Seq_HPC-7_Human1.90968122
32NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.89761729
33UTX_26944678_Chip-Seq_JUKART_Human1.85362625
34GATA3_26560356_Chip-Seq_TH2_Human1.83930907
35VDR_24763502_ChIP-Seq_THP-1_Human1.80168030
36NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.76388343
37MAF_26560356_Chip-Seq_TH2_Human1.65023482
38RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.64055815
39SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.63057722
40SPI1_23127762_ChIP-Seq_K562_Human1.61173515
41SMAD_19615063_ChIP-ChIP_OVARY_Human1.59671293
42IKZF1_21737484_ChIP-ChIP_HCT116_Human1.53067380
43EZH2_22144423_ChIP-Seq_EOC_Human1.51609656
44MYB_21317192_ChIP-Seq_ERMYB_Mouse1.51599895
45FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.51353977
46VDR_24787735_ChIP-Seq_THP-1_Human1.49705258
47VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.48717568
48MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.47279689
49ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.46183375
50LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.42637168
51SMRT_27268052_Chip-Seq_Bcells_Human1.42533233
52KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.35773618
53RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.32922101
54VDR_23849224_ChIP-Seq_CD4+_Human1.27535775
55RUNX1_22412390_ChIP-Seq_EML_Mouse1.27238985
56BP1_19119308_ChIP-ChIP_Hs578T_Human1.26745318
57IRF1_19129219_ChIP-ChIP_H3396_Human1.25428754
58LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.19305785
59BRD4_27068464_Chip-Seq_AML-cells_Mouse1.14837085
60RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.12061309
61SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.11724426
62GATA3_26560356_Chip-Seq_TH1_Human1.08333892
63PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06596463
64GATA2_22383799_ChIP-Seq_G1ME_Mouse1.04451363
65EGR1_19374776_ChIP-ChIP_THP-1_Human1.03349522
66TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01776052
67EGR1_23403033_ChIP-Seq_LIVER_Mouse1.00482701
68TCF7_22412390_ChIP-Seq_EML_Mouse0.98317584
69FOXP3_21729870_ChIP-Seq_TREG_Human0.97568163
70KDM2B_26808549_Chip-Seq_SUP-B15_Human0.97484044
71TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.96290494
72FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95656608
73FLI1_27457419_Chip-Seq_LIVER_Mouse0.95132446
74BCL6_27268052_Chip-Seq_Bcells_Human0.94428219
75* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94016216
76PU.1_20513432_ChIP-Seq_Bcells_Mouse0.93705737
77PU_27001747_Chip-Seq_BMDM_Mouse0.92719135
78GATA1_19941827_ChIP-Seq_MEL_Mouse0.91679596
79P300_27268052_Chip-Seq_Bcells_Human0.89944686
80EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.88532301
81HOXB4_20404135_ChIP-ChIP_EML_Mouse0.87476066
82Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.87410501
83CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.86437417
84* ZNF274_21170338_ChIP-Seq_K562_Hela0.85814892
85TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.81762841
86* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81417561
87BCOR_27268052_Chip-Seq_Bcells_Human0.81290706
88GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.80691061
89ERG_20887958_ChIP-Seq_HPC-7_Mouse0.79371494
90MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.79371049
91BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.78605446
92RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.75142003
93PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.74739988
94KDM2B_26808549_Chip-Seq_DND41_Human0.74616388
95SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.73166215
96E2F4_17652178_ChIP-ChIP_JURKAT_Human0.73037104
97AR_21572438_ChIP-Seq_LNCaP_Human0.71495971
98PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.69435861
99SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.68965348
100SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.66622078

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.52750773
2MP0005671_abnormal_response_to4.49576309
3MP0000685_abnormal_immune_system4.47090876
4MP0001800_abnormal_humoral_immune4.19985341
5MP0001790_abnormal_immune_system4.08146747
6MP0005387_immune_system_phenotype4.08146747
7MP0002138_abnormal_hepatobiliary_system3.29254063
8MP0005000_abnormal_immune_tolerance3.25892119
9MP0002452_abnormal_antigen_presenting3.10355920
10MP0002723_abnormal_immune_serum3.07686745
11MP0003763_abnormal_thymus_physiology2.97002220
12MP0003303_peritoneal_inflammation2.91058610
13MP0002420_abnormal_adaptive_immunity2.86037292
14MP0001819_abnormal_immune_cell2.79574666
15MP0002398_abnormal_bone_marrow2.50590231
16MP0003436_decreased_susceptibility_to2.42104977
17MP0005025_abnormal_response_to2.36331424
18MP0009785_altered_susceptibility_to2.34829332
19MP0000716_abnormal_immune_system2.34730502
20MP0005645_abnormal_hypothalamus_physiol2.34597033
21MP0005310_abnormal_salivary_gland2.34461046
22MP0000689_abnormal_spleen_morphology2.14986158
23MP0002419_abnormal_innate_immunity2.10815095
24MP0003183_abnormal_peptide_metabolism2.10058473
25MP0002166_altered_tumor_susceptibility2.03329225
26MP0002148_abnormal_hypersensitivity_rea2.02549970
27MP0003724_increased_susceptibility_to1.88705450
28MP0002429_abnormal_blood_cell1.85330665
29MP0005075_abnormal_melanosome_morpholog1.82588108
30MP0002722_abnormal_immune_system1.80708303
31MP0002405_respiratory_system_inflammati1.76187136
32MP0001845_abnormal_inflammatory_respons1.67637786
33MP0010155_abnormal_intestine_physiology1.56305573
34MP0000703_abnormal_thymus_morphology1.54270994
35MP0004381_abnormal_hair_follicle1.50801412
36MP0008057_abnormal_DNA_replication1.45964004
37MP0001873_stomach_inflammation1.44028171
38MP0000372_irregular_coat_pigmentation1.43288875
39MP0009333_abnormal_splenocyte_physiolog1.41344568
40MP0002006_tumorigenesis1.40846065
41MP0000015_abnormal_ear_pigmentation1.40749948
42MP0000569_abnormal_digit_pigmentation1.38958538
43MP0002396_abnormal_hematopoietic_system1.36711172
44MP0003300_gastrointestinal_ulcer1.34167506
45MP0002928_abnormal_bile_duct1.32799355
46MP0003045_fibrosis1.31433424
47MP0002163_abnormal_gland_morphology1.26508071
48MP0003787_abnormal_imprinting1.25143456
49MP0001348_abnormal_lacrimal_gland1.23124766
50MP0005464_abnormal_platelet_physiology1.18504647
51MP0008877_abnormal_DNA_methylation1.14466994
52MP0008469_abnormal_protein_level1.09897871
53MP0003172_abnormal_lysosome_physiology1.07640583
54MP0003252_abnormal_bile_duct0.98834752
55MP0003866_abnormal_defecation0.96344610
56MP0000371_diluted_coat_color0.96212314
57MP0002693_abnormal_pancreas_physiology0.96096003
58MP0004947_skin_inflammation0.95707531
59MP0003646_muscle_fatigue0.95568771
60MP0008872_abnormal_physiological_respon0.93802132
61MP0001986_abnormal_taste_sensitivity0.88601587
62MP0002019_abnormal_tumor_incidence0.87919457
63MP0009764_decreased_sensitivity_to0.85295225
64MP0001853_heart_inflammation0.84943221
65MP0005379_endocrine/exocrine_gland_phen0.83145627
66MP0006082_CNS_inflammation0.79877956
67MP0001533_abnormal_skeleton_physiology0.77238482
68MP0005451_abnormal_body_composition0.75844135
69MP0002009_preneoplasia0.73666699
70MP0001545_abnormal_hematopoietic_system0.69008930
71MP0005397_hematopoietic_system_phenotyp0.69008930
72MP0002095_abnormal_skin_pigmentation0.68536774
73MP0000465_gastrointestinal_hemorrhage0.67384835
74MP0010094_abnormal_chromosome_stability0.66539698
75MP0002254_reproductive_system_inflammat0.65219698
76MP0001663_abnormal_digestive_system0.63586822
77MP0002136_abnormal_kidney_physiology0.63385247
78MP0004808_abnormal_hematopoietic_stem0.63260160
79MP0004883_abnormal_blood_vessel0.62830127
80MP0006035_abnormal_mitochondrial_morpho0.62296739
81MP0002132_abnormal_respiratory_system0.61045976
82MP0005174_abnormal_tail_pigmentation0.55264750
83MP0008874_decreased_physiological_sensi0.54999595
84MP0002933_joint_inflammation0.54673151
85MP0009763_increased_sensitivity_to0.53756552
86MP0008260_abnormal_autophagy0.53116418
87MP0004510_myositis0.52826778
88MP0002653_abnormal_ependyma_morphology0.50963188
89MP0003656_abnormal_erythrocyte_physiolo0.49967440
90MP0008058_abnormal_DNA_repair0.48605945
91MP0002277_abnormal_respiratory_mucosa0.47994351
92MP0009278_abnormal_bone_marrow0.47176822
93MP0009115_abnormal_fat_cell0.46773707
94MP0000858_altered_metastatic_potential0.46674325
95MP0008961_abnormal_basal_metabolism0.46342457
96MP0009765_abnormal_xenobiotic_induced0.46341262
97MP0002168_other_aberrant_phenotype0.46080212
98MP0000249_abnormal_blood_vessel0.46065255
99MP0004142_abnormal_muscle_tone0.45968113
100MP0000490_abnormal_crypts_of0.43967527

Predicted human phenotypes

RankGene SetZ-score
1Gastrointestinal stroma tumor (HP:0100723)7.41996872
2Agammaglobulinemia (HP:0004432)7.36632337
3Recurrent sinusitis (HP:0011108)6.07524675
4Recurrent bronchitis (HP:0002837)5.33664719
5Meningitis (HP:0001287)5.29440767
6Lymphopenia (HP:0001888)5.12843467
7Abnormal delayed hypersensitivity skin test (HP:0002963)4.99899025
8Vasculitis (HP:0002633)4.84485193
9Abnormality of cells of the lymphoid lineage (HP:0012140)4.73859261
10Panhypogammaglobulinemia (HP:0003139)4.68983604
11Mediastinal lymphadenopathy (HP:0100721)4.55492164
12IgM deficiency (HP:0002850)4.49565166
13IgA deficiency (HP:0002720)4.32744967
14Recurrent viral infections (HP:0004429)4.23293379
15Cellulitis (HP:0100658)4.22863103
16Colitis (HP:0002583)4.13170640
17Recurrent bacterial skin infections (HP:0005406)4.08618760
18Recurrent cutaneous fungal infections (HP:0011370)4.01384564
19Chronic mucocutaneous candidiasis (HP:0002728)4.01384564
20Emphysema (HP:0002097)3.93829528
21IgG deficiency (HP:0004315)3.87181994
22Recurrent fungal infections (HP:0002841)3.86252930
23Recurrent pneumonia (HP:0006532)3.78510486
24Eczematoid dermatitis (HP:0000976)3.75849892
25Verrucae (HP:0200043)3.74251886
26Papilloma (HP:0012740)3.74251886
27Recurrent abscess formation (HP:0002722)3.66865609
28Inflammation of the large intestine (HP:0002037)3.53728883
29Recurrent lower respiratory tract infections (HP:0002783)3.52079908
30Abnormality of T cell physiology (HP:0011840)3.50529203
31Restrictive lung disease (HP:0002091)3.50063892
32Encephalitis (HP:0002383)3.46297183
33Gastrointestinal inflammation (HP:0004386)3.39236824
34Osteomyelitis (HP:0002754)3.29317651
35Chronic diarrhea (HP:0002028)3.27734931
36Retrobulbar optic neuritis (HP:0100654)3.26557751
37Optic neuritis (HP:0100653)3.26557751
38Recurrent skin infections (HP:0001581)3.21517536
39Abnormality of B cell number (HP:0010975)3.18459150
40Pulmonary infiltrates (HP:0002113)3.15594524
41Chronic otitis media (HP:0000389)3.10799990
42Bronchitis (HP:0012387)3.04344401
43Abnormality of T cells (HP:0002843)3.03576413
44Abnormality of macrophages (HP:0004311)2.97366418
45B lymphocytopenia (HP:0010976)2.96956937
46Urticaria (HP:0001025)2.96008729
47Lymphoma (HP:0002665)2.91868563
48Obstructive lung disease (HP:0006536)2.85369098
49Chronic obstructive pulmonary disease (HP:0006510)2.85369098
50Chronic sinusitis (HP:0011109)2.81584594
51Sepsis (HP:0100806)2.80987143
52Viral hepatitis (HP:0006562)2.77974877
53Increased IgM level (HP:0003496)2.77313972
54Recurrent gram-negative bacterial infections (HP:0005420)2.73989133
55Orchitis (HP:0100796)2.73547645
56Abnormality of the prostate (HP:0008775)2.69606201
57Leukopenia (HP:0001882)2.69498564
58Gastrointestinal infarctions (HP:0005244)2.63047830
59Basal cell carcinoma (HP:0002671)2.62545221
60Myositis (HP:0100614)2.58483682
61Recurrent otitis media (HP:0000403)2.57718220
62Skin rash (HP:0000988)2.54434078
63Chest pain (HP:0100749)2.47964767
64Increased IgE level (HP:0003212)2.41732813
65Abnormality of T cell number (HP:0011839)2.36383558
66Neutropenia (HP:0001875)2.33752093
67Hemoptysis (HP:0002105)2.29573606
68Abnormality of the pleura (HP:0002103)2.27848027
69Keratoconjunctivitis sicca (HP:0001097)2.18997535
70Arthralgia (HP:0002829)2.18514465
71Autoimmune hemolytic anemia (HP:0001890)2.16935204
72Keratoconjunctivitis (HP:0001096)2.14206270
73Elevated erythrocyte sedimentation rate (HP:0003565)2.14072297
74Hypochromic anemia (HP:0001931)2.10964185
75T lymphocytopenia (HP:0005403)2.07777450
76Abnormality of male internal genitalia (HP:0000022)2.06699861
77Pulmonary fibrosis (HP:0002206)2.01456999
78Stomatitis (HP:0010280)2.01070066
79Spontaneous hematomas (HP:0007420)2.00441570
80Granulocytopenia (HP:0001913)1.98281851
81Bronchiectasis (HP:0002110)1.95911853
82Squamous cell carcinoma (HP:0002860)1.93357759
83Eosinophilia (HP:0001880)1.92381931
84Stomach cancer (HP:0012126)1.89857667
85Pustule (HP:0200039)1.89219680
86Abnormality of eosinophils (HP:0001879)1.87226931
87Albinism (HP:0001022)1.86171070
88Skin ulcer (HP:0200042)1.85183827
89Arterial thrombosis (HP:0004420)1.84682024
90Severe combined immunodeficiency (HP:0004430)1.84214466
91Xerostomia (HP:0000217)1.83753498
92Gangrene (HP:0100758)1.81107460
93Hepatitis (HP:0012115)1.80174007
94Pulmonary embolism (HP:0002204)1.76451966
95Leukocytosis (HP:0001974)1.75152721
96Hypertensive crisis (HP:0100735)1.72957514
97Hypergammaglobulinemia (HP:0010702)1.71970057
98Hypoplasia of the thymus (HP:0000778)1.71135129
99Dry hair (HP:0011359)1.66848541
100Keratitis (HP:0000491)1.64630665

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.50889511
2RIPK45.39548745
3BLK3.44300111
4IRAK43.22674965
5SYK2.64754911
6MAP3K142.42829967
7PRPF4B2.31045810
8SIK22.28360188
9BMPR22.22124775
10BTK2.17347651
11IKBKE2.12771985
12SIK32.02278588
13TYK21.93209957
14CSF1R1.87057180
15ERN11.86337288
16IKBKB1.76047547
17TLK11.69046131
18LYN1.68085276
19FRK1.66868851
20MAP3K131.65913901
21TNK21.55278185
22TAOK31.54109929
23TBK11.53406327
24JAK11.51762394
25JAK31.49166510
26KIT1.42514228
27NEK91.37505156
28PASK1.37088499
29PRKCQ1.35971669
30CSK1.35465916
31VRK11.28420501
32HCK1.25761119
33MARK31.24450016
34MAP3K101.21159512
35TEC1.13607669
36ZAK1.12698978
37TXK1.09946112
38FGR1.03012958
39CHUK1.01484541
40EIF2AK30.99481945
41PIM10.98112716
42CDK190.96719864
43LCK0.95114097
44IRAK10.94778354
45JAK20.93002256
46ITK0.92940682
47STK100.89598239
48MATK0.87494675
49GRK60.84643261
50PDK10.79254007
51CCNB10.77414903
52FES0.74633790
53MAP4K20.72740858
54TAF10.71959052
55MAPK110.70653713
56MAPK120.65921613
57FGFR30.65613931
58YES10.65318340
59SMG10.65172305
60PRKCH0.63984528
61MAPK70.63329114
62CDK40.61159198
63RPS6KA50.60394135
64PTK2B0.59440619
65CDC42BPA0.59130248
66MELK0.53517230
67TRPM70.52094366
68STK110.51070091
69STK240.50156552
70MAPK130.48434945
71IRAK20.47010182
72MAP3K70.46945695
73PKN10.44023064
74HIPK20.41192616
75MAP3K110.41134154
76MST40.40730000
77FGFR40.40729573
78ABL10.40671243
79MAP2K30.39781235
80MAP3K50.36937533
81PRKCI0.36882858
82ZAP700.36452203
83SGK20.35733072
84FYN0.35473275
85PRKD20.35451316
86MAPK40.35321645
87OXSR10.34561595
88PRKCZ0.33050900
89PDPK10.32758784
90MAPKAPK20.32477788
91BCKDK0.30016069
92PRKCD0.28522341
93NUAK10.28075964
94PIK3CG0.27657913
95INSRR0.27174749
96DAPK30.26591734
97MAP3K80.25676229
98MAP3K10.24824643
99GRK10.24525466
100INSR0.23783009

Predicted pathways (KEGG)

RankGene SetZ-score
1Intestinal immune network for IgA production_Homo sapiens_hsa046724.68896444
2Allograft rejection_Homo sapiens_hsa053304.62262915
3Autoimmune thyroid disease_Homo sapiens_hsa053204.28640536
4Primary immunodeficiency_Homo sapiens_hsa053404.21422427
5Graft-versus-host disease_Homo sapiens_hsa053324.18249763
6Asthma_Homo sapiens_hsa053104.09808356
7Type I diabetes mellitus_Homo sapiens_hsa049403.61058039
8B cell receptor signaling pathway_Homo sapiens_hsa046623.22721015
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.91838442
10Leishmaniasis_Homo sapiens_hsa051402.78241784
11Viral myocarditis_Homo sapiens_hsa054162.56214178
12Antigen processing and presentation_Homo sapiens_hsa046122.51518854
13Staphylococcus aureus infection_Homo sapiens_hsa051502.42867539
14Systemic lupus erythematosus_Homo sapiens_hsa053222.35111665
15NF-kappa B signaling pathway_Homo sapiens_hsa040641.97383360
16Herpes simplex infection_Homo sapiens_hsa051681.80029928
17Influenza A_Homo sapiens_hsa051641.68128822
18Tuberculosis_Homo sapiens_hsa051521.62567985
19Hematopoietic cell lineage_Homo sapiens_hsa046401.57582711
20Toxoplasmosis_Homo sapiens_hsa051451.53451342
21Osteoclast differentiation_Homo sapiens_hsa043801.51315826
22Measles_Homo sapiens_hsa051621.49825379
23Toll-like receptor signaling pathway_Homo sapiens_hsa046201.46060427
24Rheumatoid arthritis_Homo sapiens_hsa053231.36632643
25Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.32122093
26Epstein-Barr virus infection_Homo sapiens_hsa051691.27701149
27T cell receptor signaling pathway_Homo sapiens_hsa046601.26842621
28RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.11946391
29Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.11524433
30Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.03164989
31Hepatitis B_Homo sapiens_hsa051611.01546675
32Jak-STAT signaling pathway_Homo sapiens_hsa046301.00874353
33Viral carcinogenesis_Homo sapiens_hsa052030.97956171
34Alcoholism_Homo sapiens_hsa050340.91460582
35Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.90596466
36Chemokine signaling pathway_Homo sapiens_hsa040620.87848204
37TNF signaling pathway_Homo sapiens_hsa046680.82596310
38Phagosome_Homo sapiens_hsa041450.79821850
39HTLV-I infection_Homo sapiens_hsa051660.76302626
40NOD-like receptor signaling pathway_Homo sapiens_hsa046210.76133190
41Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.71540654
42Apoptosis_Homo sapiens_hsa042100.71526020
43Transcriptional misregulation in cancer_Homo sapiens_hsa052020.68469618
44Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.67082563
45Acute myeloid leukemia_Homo sapiens_hsa052210.63331193
46Hepatitis C_Homo sapiens_hsa051600.61506536
47African trypanosomiasis_Homo sapiens_hsa051430.58469712
48Non-homologous end-joining_Homo sapiens_hsa034500.51588170
49Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.51207133
50Homologous recombination_Homo sapiens_hsa034400.50006614
51Non-small cell lung cancer_Homo sapiens_hsa052230.42398558
52Malaria_Homo sapiens_hsa051440.37614225
53Legionellosis_Homo sapiens_hsa051340.37566995
54Phosphatidylinositol signaling system_Homo sapiens_hsa040700.34834064
55p53 signaling pathway_Homo sapiens_hsa041150.34819933
56Neurotrophin signaling pathway_Homo sapiens_hsa047220.34330753
57Platelet activation_Homo sapiens_hsa046110.33551478
58Dorso-ventral axis formation_Homo sapiens_hsa043200.32590429
59Prolactin signaling pathway_Homo sapiens_hsa049170.32082994
60Sphingolipid signaling pathway_Homo sapiens_hsa040710.30672938
61Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.29261663
62ABC transporters_Homo sapiens_hsa020100.27656005
63Shigellosis_Homo sapiens_hsa051310.27056418
64MAPK signaling pathway_Homo sapiens_hsa040100.26799686
65Type II diabetes mellitus_Homo sapiens_hsa049300.23651110
66Carbohydrate digestion and absorption_Homo sapiens_hsa049730.22654934
67Prostate cancer_Homo sapiens_hsa052150.21917582
68Pancreatic cancer_Homo sapiens_hsa052120.21451153
69Inositol phosphate metabolism_Homo sapiens_hsa005620.21359225
70Leukocyte transendothelial migration_Homo sapiens_hsa046700.20093586
71FoxO signaling pathway_Homo sapiens_hsa040680.19094247
72Colorectal cancer_Homo sapiens_hsa052100.18822439
73RNA degradation_Homo sapiens_hsa030180.18347538
74Choline metabolism in cancer_Homo sapiens_hsa052310.17427099
75Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.17329464
76Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.15988595
77Chronic myeloid leukemia_Homo sapiens_hsa052200.15675431
78mTOR signaling pathway_Homo sapiens_hsa041500.14750809
79Fanconi anemia pathway_Homo sapiens_hsa034600.13656817
80AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.12829631
81Basal transcription factors_Homo sapiens_hsa030220.11304930
82Insulin resistance_Homo sapiens_hsa049310.10996134
83HIF-1 signaling pathway_Homo sapiens_hsa040660.10592225
84Glycerophospholipid metabolism_Homo sapiens_hsa005640.10058608
85Phospholipase D signaling pathway_Homo sapiens_hsa040720.09830933
86Renal cell carcinoma_Homo sapiens_hsa052110.09196037
87Base excision repair_Homo sapiens_hsa034100.07572656
88Adipocytokine signaling pathway_Homo sapiens_hsa049200.07144532
89alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.06296232
90VEGF signaling pathway_Homo sapiens_hsa043700.05322792
91Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.04621768
92Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.04576147
93Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.03443926
94Olfactory transduction_Homo sapiens_hsa047400.01961075
95GnRH signaling pathway_Homo sapiens_hsa049120.01359264
96Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.01007768
97Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.00974486
98SNARE interactions in vesicular transport_Homo sapiens_hsa041300.00696030
99Pertussis_Homo sapiens_hsa051330.00571914
100Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014-0.0091760

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