CLEC18A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This is one of three closely related paralogous genes on chromosome 16 encoding secreted proteins containing C-type lectin domains. These domains bind to carbohydrates in the presence of calcium, and may be involved in cell adhesion, immune response and apoptosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of mesenchymal cell apoptotic process (GO:2001054)9.38916942
2mesonephros development (GO:0001823)7.81864270
3regulation of mesenchymal cell apoptotic process (GO:2001053)7.27866328
4glomerulus development (GO:0032835)7.26554382
5metanephric mesenchyme development (GO:0072075)6.78738746
6positive regulation of gastrulation (GO:2000543)6.60769260
7negative regulation of kidney development (GO:0090185)6.55411034
8urogenital system development (GO:0001655)6.46494553
9nephron tubule formation (GO:0072079)6.35820912
10gamma-aminobutyric acid transport (GO:0015812)6.25379081
11kidney mesenchyme development (GO:0072074)6.09940183
12regulation of apoptotic process involved in morphogenesis (GO:1902337)5.94616098
13regulation of mesonephros development (GO:0061217)5.93881789
14nephron tubule development (GO:0072080)5.62901775
15regulation of branching involved in ureteric bud morphogenesis (GO:0090189)5.35159051
16head development (GO:0060322)5.25123861
17auditory receptor cell differentiation (GO:0042491)5.25034009
18positive regulation of mesonephros development (GO:0061213)5.21154695
19inner ear receptor cell differentiation (GO:0060113)5.08687364
20renal tubule development (GO:0061326)5.02490571
21nephron epithelium morphogenesis (GO:0072088)4.92070128
22nephron tubule morphogenesis (GO:0072078)4.92070128
23diaphragm development (GO:0060539)4.87426124
24mesenchymal to epithelial transition (GO:0060231)4.86103081
25embryonic retina morphogenesis in camera-type eye (GO:0060059)4.82888809
26mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)4.80487087
27metanephric epithelium development (GO:0072207)4.73492805
28regulation of nephron tubule epithelial cell differentiation (GO:0072182)4.59286255
29skeletal muscle organ development (GO:0060538)4.50182527
30response to pheromone (GO:0019236)4.49698533
31nephron epithelium development (GO:0072009)4.46274037
32positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)4.37261277
33regulation of glomerulus development (GO:0090192)4.30392391
34positive regulation of metanephros development (GO:0072216)4.29026620
35cell differentiation involved in metanephros development (GO:0072202)4.17412561
36mechanoreceptor differentiation (GO:0042490)4.13944358
37epithelial cell differentiation involved in kidney development (GO:0035850)4.12682861
38Notch signaling involved in heart development (GO:0061314)4.05890377
39regulation of male gonad development (GO:2000018)3.98533273
40somite rostral/caudal axis specification (GO:0032525)3.93875016
41regulation of stem cell maintenance (GO:2000036)3.90169244
42uterus development (GO:0060065)3.87353737
43auditory receptor cell stereocilium organization (GO:0060088)3.86206122
44regulation of epithelial cell differentiation involved in kidney development (GO:2000696)3.82121170
45sulfation (GO:0051923)3.81092514
46regulation of cell proliferation involved in kidney development (GO:1901722)3.78104881
47glial cell proliferation (GO:0014009)3.77575379
48regulation of metanephros development (GO:0072215)3.77000924
49signal peptide processing (GO:0006465)3.76085983
50renal tubule morphogenesis (GO:0061333)3.75798162
51positive regulation of protein kinase C signaling (GO:0090037)3.72810570
52cranial nerve structural organization (GO:0021604)3.65566223
53cell wall macromolecule metabolic process (GO:0044036)3.65469195
54retina layer formation (GO:0010842)3.63182036
55positive regulation of male gonad development (GO:2000020)3.61687886
56L-fucose catabolic process (GO:0042355)3.58642155
57fucose catabolic process (GO:0019317)3.58642155
58L-fucose metabolic process (GO:0042354)3.58642155
59DNA deamination (GO:0045006)3.58578801
60primitive streak formation (GO:0090009)3.57849438
61cerebellar Purkinje cell differentiation (GO:0021702)3.55932966
62cell differentiation involved in kidney development (GO:0061005)3.55302748
63regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033393.52683991
64platelet dense granule organization (GO:0060155)3.49556890
65negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.49288937
66pattern specification involved in kidney development (GO:0061004)3.38873832
67behavioral response to nicotine (GO:0035095)3.36492017
68embryonic viscerocranium morphogenesis (GO:0048703)3.35437469
69mesenchymal cell differentiation involved in kidney development (GO:0072161)3.34011574
70mesenchymal cell differentiation involved in renal system development (GO:2001012)3.34011574
71positive regulation of kidney development (GO:0090184)3.32993738
72photoreceptor cell development (GO:0042461)3.31620382
73kidney epithelium development (GO:0072073)3.30152726
74hindbrain development (GO:0030902)3.29372713
75motor neuron axon guidance (GO:0008045)3.27828746
76mitotic chromosome condensation (GO:0007076)3.26795446
77retinal cone cell development (GO:0046549)3.26155808
78regulation of mitotic spindle checkpoint (GO:1903504)3.24168156
79regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.24168156
80specification of organ identity (GO:0010092)3.23085342
81fusion of sperm to egg plasma membrane (GO:0007342)3.21034173
82eye photoreceptor cell development (GO:0042462)3.21034091
83negative regulation of interleukin-1 beta production (GO:0032691)3.15123753
84detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.14094702
85cellular ketone body metabolic process (GO:0046950)3.12907039
86inner ear receptor stereocilium organization (GO:0060122)3.12800435
87activated T cell proliferation (GO:0050798)3.10762706
88regulation of kidney development (GO:0090183)3.10439498
89cellular response to interleukin-15 (GO:0071350)3.07064072
90cornea development in camera-type eye (GO:0061303)3.06336090
91indolalkylamine metabolic process (GO:0006586)3.04269503
92positive regulation of cell cycle checkpoint (GO:1901978)3.03327260
93centriole replication (GO:0007099)3.03133483
94regulation of short-term neuronal synaptic plasticity (GO:0048172)3.02145190
95regulation of non-canonical Wnt signaling pathway (GO:2000050)3.02054023
96mechanosensory behavior (GO:0007638)3.01853187
97vagina development (GO:0060068)3.00246036
98spinal cord association neuron differentiation (GO:0021527)2.99242111
99negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.98267684
100negative regulation of T-helper cell differentiation (GO:0045623)2.98267684
101postsynaptic membrane organization (GO:0001941)2.97173502
102adenine nucleotide transport (GO:0051503)2.96581557
103alkaloid metabolic process (GO:0009820)2.95409418
104regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.95380877
105antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.94283081
106facial nerve structural organization (GO:0021612)2.92291071
107negative regulation of interleukin-1 production (GO:0032692)2.92251867
108presynaptic membrane assembly (GO:0097105)2.92235922
109regulation of heat generation (GO:0031650)2.88767452
110dentate gyrus development (GO:0021542)2.86967624
111embryonic epithelial tube formation (GO:0001838)2.83055177
112metanephros development (GO:0001656)2.81973558
113deoxyribose phosphate biosynthetic process (GO:0046385)2.81157076
1142-deoxyribonucleotide biosynthetic process (GO:0009265)2.81157076
115synaptic vesicle docking involved in exocytosis (GO:0016081)2.81130656
116glomerular basement membrane development (GO:0032836)2.81008385
117regulation of gastrulation (GO:0010470)2.80932352
118cellular biogenic amine catabolic process (GO:0042402)2.79922913
119amine catabolic process (GO:0009310)2.79922913
120tryptophan catabolic process (GO:0006569)2.79869301
121indole-containing compound catabolic process (GO:0042436)2.79869301
122indolalkylamine catabolic process (GO:0046218)2.79869301
123branching involved in ureteric bud morphogenesis (GO:0001658)2.79083513
124opioid receptor signaling pathway (GO:0038003)2.78374502
125negative regulation of synaptic transmission, GABAergic (GO:0032229)2.77901121
126mesonephric tubule development (GO:0072164)2.77670323
127metanephric nephron tubule development (GO:0072234)2.77607475
128metanephric tubule development (GO:0072170)2.77607475
129ketone body metabolic process (GO:1902224)2.76341117
130ureteric bud development (GO:0001657)2.76002918
131startle response (GO:0001964)2.74878496
132cardiac right ventricle morphogenesis (GO:0003215)2.74606145
133protein K11-linked deubiquitination (GO:0035871)2.74589498
134negative regulation of alpha-beta T cell activation (GO:0046636)2.70946729
135plasma membrane fusion (GO:0045026)2.70155604
136response to interleukin-15 (GO:0070672)2.69855578
137axonal fasciculation (GO:0007413)2.69308873
138endoderm formation (GO:0001706)2.69254850
139regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.68353125
140epithelial tube formation (GO:0072175)2.67783591
141positive regulation of embryonic development (GO:0040019)2.66857299
142mesonephric epithelium development (GO:0072163)2.66678965
143photoreceptor cell maintenance (GO:0045494)2.66539294
144positive regulation of heat generation (GO:0031652)2.66298031
145purine ribonucleotide transport (GO:0015868)2.66150520
146tryptophan metabolic process (GO:0006568)2.65019461
147basic amino acid transport (GO:0015802)2.63861520
148synaptic transmission, cholinergic (GO:0007271)2.62221124
149regulation of respiratory system process (GO:0044065)2.60495677
150negative regulation of alpha-beta T cell differentiation (GO:0046639)2.58569199
151neuron maturation (GO:0042551)2.54361749
152reflex (GO:0060004)2.46491170
153multicellular organism reproduction (GO:0032504)2.45823385
154positive regulation of T cell mediated cytotoxicity (GO:0001916)2.45698290
155interferon-gamma production (GO:0032609)2.44051529
156glycerophospholipid catabolic process (GO:0046475)2.43569083
157cytidine metabolic process (GO:0046087)2.42487226
158cytidine catabolic process (GO:0006216)2.42487226
159cytidine deamination (GO:0009972)2.42487226
160water-soluble vitamin biosynthetic process (GO:0042364)2.42089396
161adaptation of signaling pathway (GO:0023058)2.39804024
162detection of light stimulus involved in visual perception (GO:0050908)2.39340806
163detection of light stimulus involved in sensory perception (GO:0050962)2.39340806
164presynaptic membrane organization (GO:0097090)2.37890552
165regulation of B cell receptor signaling pathway (GO:0050855)2.36788136
166epithelial cilium movement (GO:0003351)2.36356586
167pyrimidine nucleobase catabolic process (GO:0006208)2.36271382
168negative regulation of cell killing (GO:0031342)2.35904310
169negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.35904310
170negative regulation of protein oligomerization (GO:0032460)2.34797558
171production of molecular mediator involved in inflammatory response (GO:0002532)2.34076757
172cell wall macromolecule catabolic process (GO:0016998)2.33065886
173visual perception (GO:0007601)2.33026007
174sensory perception of light stimulus (GO:0050953)2.32733680
175neuropeptide signaling pathway (GO:0007218)2.30209510
176organic cation transport (GO:0015695)2.30145880
177glucosamine-containing compound catabolic process (GO:1901072)2.27576509
178kynurenine metabolic process (GO:0070189)2.26956241
179calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.26734752
180preassembly of GPI anchor in ER membrane (GO:0016254)2.26173789
181indole-containing compound metabolic process (GO:0042430)2.25214253
182neurotransmitter catabolic process (GO:0042135)2.23502920
183negative regulation of mast cell activation (GO:0033004)2.23165419
184rRNA catabolic process (GO:0016075)2.22654036
185positive regulation of CREB transcription factor activity (GO:0032793)2.20453518
186cilium or flagellum-dependent cell motility (GO:0001539)2.19183521
187negative regulation of cytosolic calcium ion concentration (GO:0051481)2.19065593
188GPI anchor metabolic process (GO:0006505)2.18570924
189parturition (GO:0007567)2.17511409
190epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.16842861
191regulation of T cell mediated cytotoxicity (GO:0001914)2.16672020
192regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.16006370
193neural tube formation (GO:0001841)2.15981691
194regulation of respiratory gaseous exchange (GO:0043576)2.15812169
195negative regulation of metanephros development (GO:0072217)10.3451298

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.21018563
2GBX2_23144817_ChIP-Seq_PC3_Human4.80357287
3ZNF274_21170338_ChIP-Seq_K562_Hela3.89598087
4VDR_22108803_ChIP-Seq_LS180_Human2.72524588
5CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.70593209
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.65055182
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.51078989
8EED_16625203_ChIP-ChIP_MESCs_Mouse2.50363581
9SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.48796591
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.47143284
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.46446053
12E2F7_22180533_ChIP-Seq_HELA_Human2.45681882
13FUS_26573619_Chip-Seq_HEK293_Human2.42246885
14BMI1_23680149_ChIP-Seq_NPCS_Mouse2.41352631
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.32186356
16SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.30926414
17RNF2_18974828_ChIP-Seq_MESCs_Mouse2.23124555
18EZH2_18974828_ChIP-Seq_MESCs_Mouse2.23124555
19CBX2_27304074_Chip-Seq_ESCs_Mouse2.22202064
20RNF2_27304074_Chip-Seq_NSC_Mouse2.22051394
21SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.20099976
22CTBP2_25329375_ChIP-Seq_LNCAP_Human2.15884352
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.15287131
24SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.11536315
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.07117448
26IRF8_22096565_ChIP-ChIP_GC-B_Human2.02627933
27PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.02225406
28RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.95331947
29SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.95049988
30P300_19829295_ChIP-Seq_ESCs_Human1.92627731
31RNF2_27304074_Chip-Seq_ESCs_Mouse1.92593738
32GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.90516066
33POU3F2_20337985_ChIP-ChIP_501MEL_Human1.87567994
34FLI1_27457419_Chip-Seq_LIVER_Mouse1.87125696
35RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.85829947
36EWS_26573619_Chip-Seq_HEK293_Human1.84347046
37EZH2_27294783_Chip-Seq_ESCs_Mouse1.81993422
38NANOG_18555785_Chip-Seq_ESCs_Mouse1.73187450
39POU5F1_16153702_ChIP-ChIP_HESCs_Human1.69928293
40MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.68215152
41TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.65707061
42SUZ12_27294783_Chip-Seq_ESCs_Mouse1.65394826
43TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.63587625
44E2F1_18555785_Chip-Seq_ESCs_Mouse1.61388976
45STAT6_21828071_ChIP-Seq_BEAS2B_Human1.60599168
46STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.60185883
47BCAT_22108803_ChIP-Seq_LS180_Human1.59208661
48REST_21632747_ChIP-Seq_MESCs_Mouse1.57212326
49PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.56305553
50MTF2_20144788_ChIP-Seq_MESCs_Mouse1.55294455
51* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.54779739
52* POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.54779739
53OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.53539505
54SMAD3_21741376_ChIP-Seq_EPCs_Human1.53502698
55SMAD4_21799915_ChIP-Seq_A2780_Human1.53376568
56TAF15_26573619_Chip-Seq_HEK293_Human1.52419672
57STAT3_18555785_Chip-Seq_ESCs_Mouse1.50111311
58LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.49254564
59TP53_22573176_ChIP-Seq_HFKS_Human1.48554179
60SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.48373807
61IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.48276915
62P300_18555785_Chip-Seq_ESCs_Mouse1.47331383
63SOX9_26525672_Chip-Seq_HEART_Mouse1.46272912
64SUZ12_18555785_Chip-Seq_ESCs_Mouse1.46131995
65CTBP1_25329375_ChIP-Seq_LNCAP_Human1.45453481
66IGF1R_20145208_ChIP-Seq_DFB_Human1.45126035
67CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.43684496
68EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.42909885
69DROSHA_22980978_ChIP-Seq_HELA_Human1.42852830
70SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.42166211
71EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.40368930
72P53_22387025_ChIP-Seq_ESCs_Mouse1.40306928
73MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.39752467
74CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38634299
75CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.37369732
76PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.37002853
77SOX2_18555785_Chip-Seq_ESCs_Mouse1.32383692
78EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.32037632
79CMYC_18555785_Chip-Seq_ESCs_Mouse1.30921894
80TP53_18474530_ChIP-ChIP_U2OS_Human1.30474542
81AR_20517297_ChIP-Seq_VCAP_Human1.29922959
82NANOG_19829295_ChIP-Seq_ESCs_Human1.29726371
83SOX2_19829295_ChIP-Seq_ESCs_Human1.29726371
84SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29382281
85SUZ12_27294783_Chip-Seq_NPCs_Mouse1.28378001
86NMYC_18555785_Chip-Seq_ESCs_Mouse1.28132609
87P53_22127205_ChIP-Seq_FIBROBLAST_Human1.27788097
88KLF4_18555785_Chip-Seq_ESCs_Mouse1.25433703
89PCGF2_27294783_Chip-Seq_ESCs_Mouse1.25232565
90NCOR_22424771_ChIP-Seq_293T_Human1.24684344
91FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.24337211
92NOTCH1_21737748_ChIP-Seq_TLL_Human1.23664112
93FOXA1_27270436_Chip-Seq_PROSTATE_Human1.23387177
94FOXA1_25329375_ChIP-Seq_VCAP_Human1.23387177
95ETV2_25802403_ChIP-Seq_MESCs_Mouse1.23320257
96GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.22971307
97AR_25329375_ChIP-Seq_VCAP_Human1.22964977
98TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21509960
99LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.20966057
100UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.20455322
101REST_18959480_ChIP-ChIP_MESCs_Mouse1.19283226
102RUNX2_22187159_ChIP-Seq_PCA_Human1.19242344
103IRF8_21731497_ChIP-ChIP_J774_Mouse1.19220469
104CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.18724048
105PIAS1_25552417_ChIP-Seq_VCAP_Human1.18082103
106PCGF2_27294783_Chip-Seq_NPCs_Mouse1.17595664
107NR3C1_21868756_ChIP-Seq_MCF10A_Human1.17402536
108EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.16699726
109TOP2B_26459242_ChIP-Seq_MCF-7_Human1.16673016
110ZFX_18555785_Chip-Seq_ESCs_Mouse1.15907469
111RING1B_27294783_Chip-Seq_ESCs_Mouse1.15545475
112STAT3_23295773_ChIP-Seq_U87_Human1.14071038
113AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.14023823
114LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13950047
115TCF4_23295773_ChIP-Seq_U87_Human1.13873291
116AR_21572438_ChIP-Seq_LNCaP_Human1.13783838
117CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.13693037
118PRDM14_20953172_ChIP-Seq_ESCs_Human1.12924187
119PU1_27457419_Chip-Seq_LIVER_Mouse1.12829998
120NFE2_27457419_Chip-Seq_LIVER_Mouse1.12652331
121SOX2_18555785_ChIP-Seq_MESCs_Mouse1.12322354
122GATA3_26560356_Chip-Seq_TH2_Human1.12192865
123IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.11323007
124CBP_20019798_ChIP-Seq_JUKART_Human1.11323007
125ER_23166858_ChIP-Seq_MCF-7_Human1.11296951
126OCT4_18555785_Chip-Seq_ESCs_Mouse1.10985056
127SMAD1_18555785_Chip-Seq_ESCs_Mouse1.10421127
128* FOXH1_21741376_ChIP-Seq_EPCs_Human1.10410870
129ESR1_20079471_ChIP-ChIP_T-47D_Human1.09666592
130TAF2_19829295_ChIP-Seq_ESCs_Human1.09258507
131EGR1_23403033_ChIP-Seq_LIVER_Mouse1.08299706
132GATA3_21878914_ChIP-Seq_MCF-7_Human1.07853405
133HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.07097657
134SMAD4_21741376_ChIP-Seq_EPCs_Human1.06824408
135HTT_18923047_ChIP-ChIP_STHdh_Human1.06799239
136ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.06760111
137EZH2_27294783_Chip-Seq_NPCs_Mouse1.05857005
138TCF4_22108803_ChIP-Seq_LS180_Human1.05835780
139PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.05480388
140JUN_21703547_ChIP-Seq_K562_Human1.05129138
141KDM2B_26808549_Chip-Seq_REH_Human1.04768793
142CTCF_18555785_Chip-Seq_ESCs_Mouse1.04677692
143MYC_19829295_ChIP-Seq_ESCs_Human1.04455166
144NANOG_20526341_ChIP-Seq_ESCs_Human1.01613564
145BP1_19119308_ChIP-ChIP_Hs578T_Human1.00663958
146VDR_24787735_ChIP-Seq_THP-1_Human1.00246846
147VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.99538474
148* HOXB7_26014856_ChIP-Seq_BT474_Human0.98620092
149IRF1_19129219_ChIP-ChIP_H3396_Human0.97877340
150TP53_16413492_ChIP-PET_HCT116_Human0.97458678
151IKZF1_21737484_ChIP-ChIP_HCT116_Human0.97445629
152SMRT_27268052_Chip-Seq_Bcells_Human0.96900503
153RUNX_20019798_ChIP-Seq_JUKART_Human0.95374967
154BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.94659166
155FOXA1_21572438_ChIP-Seq_LNCaP_Human0.93884115

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.41514522
2MP0002138_abnormal_hepatobiliary_system4.28353477
3MP0002928_abnormal_bile_duct4.06960449
4MP0005084_abnormal_gallbladder_morpholo3.62024723
5MP0003941_abnormal_skin_development3.47176526
6MP0006292_abnormal_olfactory_placode3.30805881
7MP0003942_abnormal_urinary_system3.18667250
8MP0002638_abnormal_pupillary_reflex2.97074254
9MP0003879_abnormal_hair_cell2.91730858
10MP0003880_abnormal_central_pattern2.65896807
11MP0003195_calcinosis2.65593515
12MP0000538_abnormal_urinary_bladder2.39399354
13MP0004859_abnormal_synaptic_plasticity2.25102695
14MP0000013_abnormal_adipose_tissue2.19928694
15MP0003943_abnormal_hepatobiliary_system2.19730664
16MP0005409_darkened_coat_color2.16825238
17MP0003724_increased_susceptibility_to2.14840978
18MP0000534_abnormal_ureter_morphology2.12270572
19MP0003787_abnormal_imprinting2.09416125
20MP0003890_abnormal_embryonic-extraembry2.07951107
21MP0001501_abnormal_sleep_pattern2.05484114
22MP0003123_paternal_imprinting1.96722049
23MP0001485_abnormal_pinna_reflex1.95240680
24MP0002876_abnormal_thyroid_physiology1.94332391
25MP0005671_abnormal_response_to1.91776193
26MP0000026_abnormal_inner_ear1.90006780
27MP0003122_maternal_imprinting1.89081804
28MP0002735_abnormal_chemical_nociception1.85102397
29MP0000569_abnormal_digit_pigmentation1.83936185
30MP0008872_abnormal_physiological_respon1.73625170
31MP0005646_abnormal_pituitary_gland1.72568287
32MP0001486_abnormal_startle_reflex1.67307827
33MP0006072_abnormal_retinal_apoptosis1.65013744
34MP0003635_abnormal_synaptic_transmissio1.64617345
35MP0005645_abnormal_hypothalamus_physiol1.61952119
36MP0008875_abnormal_xenobiotic_pharmacok1.59940093
37MP0001188_hyperpigmentation1.59507082
38MP0001963_abnormal_hearing_physiology1.58507024
39MP0002184_abnormal_innervation1.58165031
40MP0002102_abnormal_ear_morphology1.57906936
41MP0005083_abnormal_biliary_tract1.57268406
42MP0003121_genomic_imprinting1.55808945
43MP0001529_abnormal_vocalization1.55278155
44MP0000631_abnormal_neuroendocrine_gland1.52707324
45MP0005423_abnormal_somatic_nervous1.50839644
46MP0003136_yellow_coat_color1.49345595
47MP0000778_abnormal_nervous_system1.47435176
48MP0004019_abnormal_vitamin_homeostasis1.46828732
49MP0003878_abnormal_ear_physiology1.46453019
50MP0005377_hearing/vestibular/ear_phenot1.46453019
51MP0003938_abnormal_ear_development1.46076357
52MP0000566_synostosis1.37356412
53MP0002938_white_spotting1.35268885
54MP0001968_abnormal_touch/_nociception1.34678429
55MP0006276_abnormal_autonomic_nervous1.34448246
56MP0001986_abnormal_taste_sensitivity1.33919162
57MP0000427_abnormal_hair_cycle1.31995182
58MP0002277_abnormal_respiratory_mucosa1.31602341
59MP0000049_abnormal_middle_ear1.31013076
60MP0002736_abnormal_nociception_after1.29801384
61MP0001919_abnormal_reproductive_system1.29586795
62MP0002063_abnormal_learning/memory/cond1.29113638
63MP0002822_catalepsy1.29009236
64MP0005551_abnormal_eye_electrophysiolog1.28556611
65MP0001502_abnormal_circadian_rhythm1.25688398
66MP0000955_abnormal_spinal_cord1.24958502
67MP0002572_abnormal_emotion/affect_behav1.23897904
68MP0002064_seizures1.22370640
69MP0005075_abnormal_melanosome_morpholog1.20938837
70MP0004043_abnormal_pH_regulation1.19595272
71MP0002272_abnormal_nervous_system1.19570065
72MP0005174_abnormal_tail_pigmentation1.19091864
73MP0001800_abnormal_humoral_immune1.18715805
74MP0003045_fibrosis1.18190599
75MP0002234_abnormal_pharynx_morphology1.17095128
76MP0002067_abnormal_sensory_capabilities1.16916208
77MP0005171_absent_coat_pigmentation1.14048724
78MP0005365_abnormal_bile_salt1.12454836
79MP0002653_abnormal_ependyma_morphology1.12345105
80MP0001835_abnormal_antigen_presentation1.11926858
81MP0002557_abnormal_social/conspecific_i1.11790171
82MP0002095_abnormal_skin_pigmentation1.11331122
83MP0009785_altered_susceptibility_to1.10939955
84MP0004742_abnormal_vestibular_system1.10801486
85MP0005085_abnormal_gallbladder_physiolo1.10091080
86MP0003115_abnormal_respiratory_system1.09872076
87MP0009745_abnormal_behavioral_response1.09291876
88MP0000681_abnormal_thyroid_gland1.08748589
89MP0002882_abnormal_neuron_morphology1.08346069
90MP0009053_abnormal_anal_canal1.07230336
91MP0010329_abnormal_lipoprotein_level1.07016508
92MP0002752_abnormal_somatic_nervous1.06963983
93MP0003011_delayed_dark_adaptation1.06884487
94MP0001790_abnormal_immune_system1.06426971
95MP0005387_immune_system_phenotype1.06426971
96MP0004142_abnormal_muscle_tone1.06328093
97MP0009046_muscle_twitch1.05086400
98MP0001324_abnormal_eye_pigmentation1.04588724
99MP0005360_urolithiasis1.02352126
100MP0005389_reproductive_system_phenotype1.00770511
101MP0003252_abnormal_bile_duct1.00504949
102MP0001970_abnormal_pain_threshold0.99728686
103MP0004233_abnormal_muscle_weight0.99125085
104MP0006082_CNS_inflammation0.98305974
105MP0010386_abnormal_urinary_bladder0.97995941
106MP0005167_abnormal_blood-brain_barrier0.97528687
107MP0002723_abnormal_immune_serum0.97247943
108MP0003183_abnormal_peptide_metabolism0.97200635
109MP0002733_abnormal_thermal_nociception0.94713327
110MP0001286_abnormal_eye_development0.92757219
111MP0005195_abnormal_posterior_eye0.91687336
112MP0008995_early_reproductive_senescence0.90281980
113MP0005000_abnormal_immune_tolerance0.88968956
114MP0002933_joint_inflammation0.88675099
115MP0001905_abnormal_dopamine_level0.88609965
116MP0009764_decreased_sensitivity_to0.88432651
117MP0002734_abnormal_mechanical_nocicepti0.87670671
118MP0000647_abnormal_sebaceous_gland0.86397054
119MP0003436_decreased_susceptibility_to0.85931096
120MP0003638_abnormal_response/metabolism_0.85869662
121MP0006138_congestive_heart_failure0.84951251
122MP0009278_abnormal_bone_marrow0.84766151
123MP0004484_altered_response_of0.84661832
124MP0001440_abnormal_grooming_behavior0.82372632
125MP0004885_abnormal_endolymph0.82172562
126MP0003283_abnormal_digestive_organ0.81526896
127MP0005448_abnormal_energy_balance0.81346128
128MP0001663_abnormal_digestive_system0.80768305
129MP0004133_heterotaxia0.80499778
130MP0001177_atelectasis0.80396805
131MP0005535_abnormal_body_temperature0.80128848
132MP0004147_increased_porphyrin_level0.79684695
133MP0003690_abnormal_glial_cell0.78600460
134MP0002419_abnormal_innate_immunity0.78594850
135MP0005410_abnormal_fertilization0.78487732
136MP0001764_abnormal_homeostasis0.77682447
137MP0004811_abnormal_neuron_physiology0.76205873
138MP0005332_abnormal_amino_acid0.75861977
139MP0005025_abnormal_response_to0.75675087
140MP0004924_abnormal_behavior0.75456092
141MP0005386_behavior/neurological_phenoty0.75456092
142MP0002909_abnormal_adrenal_gland0.72883551
143MP0003385_abnormal_body_wall0.70072122
144MP0008877_abnormal_DNA_methylation0.69862702
145MP0000015_abnormal_ear_pigmentation0.68299963
146MP0002152_abnormal_brain_morphology0.67970641
147MP0001984_abnormal_olfaction0.67880732
148MP0003936_abnormal_reproductive_system0.67117327
149MP0000678_abnormal_parathyroid_gland0.66921622
150MP0002751_abnormal_autonomic_nervous0.65762108
151MP0005248_abnormal_Harderian_gland0.64214890
152MP0003861_abnormal_nervous_system0.64005626
153MP0000372_irregular_coat_pigmentation0.60277335
154MP0002109_abnormal_limb_morphology0.60080230
155MP0005253_abnormal_eye_physiology0.60026909
156MP0005197_abnormal_uvea_morphology0.59720166

Predicted human phenotypes

RankGene SetZ-score
1Abnormal pancreas size (HP:0012094)9.35666184
2Bicornuate uterus (HP:0000813)6.03715331
3Shawl scrotum (HP:0000049)5.99653690
4Bifid tongue (HP:0010297)5.47889214
5Anomalous pulmonary venous return (HP:0010772)4.69426917
6Abnormal lung lobation (HP:0002101)4.66806493
7Chorioretinal atrophy (HP:0000533)4.58787352
8Renal hypoplasia (HP:0000089)4.54720753
9Retrobulbar optic neuritis (HP:0100654)4.42384379
10Optic neuritis (HP:0100653)4.42384379
11Unilateral renal agenesis (HP:0000122)4.38732518
12Renal dysplasia (HP:0000110)4.36890483
13Hypoplasia of the uterus (HP:0000013)4.04402765
14Gout (HP:0001997)4.01424452
15Mesangial abnormality (HP:0001966)4.00558683
16Abnormality of the pulmonary veins (HP:0011718)3.94154922
17Orchitis (HP:0100796)3.84536916
18Facial cleft (HP:0002006)3.80279116
19Abolished electroretinogram (ERG) (HP:0000550)3.70422891
20True hermaphroditism (HP:0010459)3.66956064
21Attenuation of retinal blood vessels (HP:0007843)3.56515283
22Myositis (HP:0100614)3.49175919
23Aplasia/hypoplasia of the uterus (HP:0008684)3.42618887
24Elevated erythrocyte sedimentation rate (HP:0003565)3.39668762
25Absent eyebrow (HP:0002223)3.35690582
26Morphological abnormality of the middle ear (HP:0008609)3.35018506
27Pancreatic cysts (HP:0001737)3.34947268
28Vertebral arch anomaly (HP:0008438)3.33646613
29Prolonged neonatal jaundice (HP:0006579)3.24838929
30Nephroblastoma (Wilms tumor) (HP:0002667)3.20150386
31Papillary thyroid carcinoma (HP:0002895)3.19030279
32Bilateral microphthalmos (HP:0007633)3.13934456
33Focal motor seizures (HP:0011153)3.10077194
34Midline defect of the nose (HP:0004122)3.04743113
35Abnormality of the lacrimal duct (HP:0011481)3.03464207
36Congenital stationary night blindness (HP:0007642)3.00937619
37Hypothermia (HP:0002045)2.99968826
38Embryonal renal neoplasm (HP:0011794)2.97137305
39Stomach cancer (HP:0012126)2.94128965
40Periauricular skin pits (HP:0100277)2.94127345
41Preauricular pit (HP:0004467)2.94127345
42Hypoplastic left heart (HP:0004383)2.90954046
43Vaginal atresia (HP:0000148)2.90933068
44Decreased electroretinogram (ERG) amplitude (HP:0000654)2.90063438
45Genital tract atresia (HP:0001827)2.89702825
46Exocrine pancreatic insufficiency (HP:0001738)2.84604302
47Abnormality of the nasolacrimal system (HP:0000614)2.84208268
48Absent rod-and cone-mediated responses on ERG (HP:0007688)2.84035200
49Long nose (HP:0003189)2.82109816
503-Methylglutaconic aciduria (HP:0003535)2.80401034
51Febrile seizures (HP:0002373)2.78246661
52Nuclear cataract (HP:0100018)2.74351416
53Nephronophthisis (HP:0000090)2.73495929
54Anophthalmia (HP:0000528)2.72398404
55Keratoconjunctivitis (HP:0001096)2.72069322
56Stomatitis (HP:0010280)2.71823593
57Thyroid-stimulating hormone excess (HP:0002925)2.71545077
58Decreased central vision (HP:0007663)2.67946858
59Absent eyelashes (HP:0000561)2.67459410
60Type II lissencephaly (HP:0007260)2.64787971
61Encephalitis (HP:0002383)2.64181220
62Gastrointestinal infarctions (HP:0005244)2.63830677
63Anterior segment dysgenesis (HP:0007700)2.59019719
64Keratoconjunctivitis sicca (HP:0001097)2.54795785
65Glucose intolerance (HP:0000833)2.53794950
66Abnormality of the renal cortex (HP:0011035)2.52095166
67Increased corneal curvature (HP:0100692)2.50422259
68Keratoconus (HP:0000563)2.50422259
69Clumsiness (HP:0002312)2.50327694
70Stage 5 chronic kidney disease (HP:0003774)2.46347937
71Abnormal rod and cone electroretinograms (HP:0008323)2.45952316
72Hypoplastic heart (HP:0001961)2.45433106
73Hyperventilation (HP:0002883)2.43824239
74Renal tubular acidosis (HP:0001947)2.40499464
75Abnormality of the labia minora (HP:0012880)2.39843477
76Tubulointerstitial nephritis (HP:0001970)2.39339567
77Median cleft lip (HP:0000161)2.38620423
78Pulmonary artery stenosis (HP:0004415)2.35259087
79Tubular atrophy (HP:0000092)2.34073967
80Progressive sensorineural hearing impairment (HP:0000408)2.33554163
81Epileptic encephalopathy (HP:0200134)2.32462929
82Ureteral stenosis (HP:0000071)2.32367995
83Congenital sensorineural hearing impairment (HP:0008527)2.31328099
84Late onset (HP:0003584)2.29575262
85Ureteral obstruction (HP:0006000)2.28575746
86Thyroid carcinoma (HP:0002890)2.27981230
87Cutaneous finger syndactyly (HP:0010554)2.27737057
88Ectopic anus (HP:0004397)2.27708638
89Aplasia/Hypoplasia of the sternum (HP:0006714)2.26397263
90Cerebellar dysplasia (HP:0007033)2.24763702
91Focal segmental glomerulosclerosis (HP:0000097)2.24244894
92Enlarged kidneys (HP:0000105)2.21893557
93Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.20558619
94Abnormal hair whorl (HP:0010721)2.17941254
95Large for gestational age (HP:0001520)2.17293104
96Chronic hepatic failure (HP:0100626)2.15753765
97Cutaneous syndactyly (HP:0012725)2.14876944
98Oligohydramnios (HP:0001562)2.12976709
99Pancreatic fibrosis (HP:0100732)2.11746745
100Annular pancreas (HP:0001734)2.11600788
101Arthropathy (HP:0003040)2.11395642
102Hypoplastic ischia (HP:0003175)2.07517716
103Septo-optic dysplasia (HP:0100842)2.05405046
104Macular degeneration (HP:0000608)2.05214995
105Tented upper lip vermilion (HP:0010804)2.04889548
106Bony spicule pigmentary retinopathy (HP:0007737)2.04126614
107Medial flaring of the eyebrow (HP:0010747)2.02822218
108Increased purine levels (HP:0004368)2.02738205
109Hyperuricemia (HP:0002149)2.02738205
110Hemoptysis (HP:0002105)2.00590129
111Abnormality of the renal medulla (HP:0100957)1.99094172
112Cystic liver disease (HP:0006706)1.98223413
113Short tibia (HP:0005736)1.97652777
114Recurrent cutaneous fungal infections (HP:0011370)1.94822106
115Chronic mucocutaneous candidiasis (HP:0002728)1.94822106
116Potter facies (HP:0002009)1.94130645
117Facial shape deformation (HP:0011334)1.94130645
118Ketosis (HP:0001946)1.93869648
119Keratitis (HP:0000491)1.93469091
120Preaxial hand polydactyly (HP:0001177)1.93437096
121Neoplasm of the liver (HP:0002896)1.92796142
122Retinal atrophy (HP:0001105)1.92420779
123Aplasia/Hypoplasia of the tibia (HP:0005772)1.91504644
124Abnormality of midbrain morphology (HP:0002418)1.90603929
125Molar tooth sign on MRI (HP:0002419)1.90603929
126Choanal stenosis (HP:0000452)1.90547616
127Hypoplasia of the pons (HP:0012110)1.89039616
128Gaze-evoked nystagmus (HP:0000640)1.87684818
129Abnormal delayed hypersensitivity skin test (HP:0002963)1.87358122
130Inability to walk (HP:0002540)1.87099453
131Abnormal glucose tolerance (HP:0001952)1.86412576
132Skin pits (HP:0100276)1.86253603
133Hypomagnesemia (HP:0002917)1.85312976
134Abnormal drinking behavior (HP:0030082)1.84644212
135Polydipsia (HP:0001959)1.84644212
136Hemiparesis (HP:0001269)1.84520085
137Pigmentary retinal degeneration (HP:0001146)1.83916862
138Pulmonary infiltrates (HP:0002113)1.83443978
139Embryonal neoplasm (HP:0002898)1.82657037
140Progressive inability to walk (HP:0002505)1.82470876
141Fair hair (HP:0002286)1.82331097
142Polyphagia (HP:0002591)1.82246816
143Colon cancer (HP:0003003)1.81926944
144Abnormality of the pons (HP:0007361)1.81334855
145Postaxial foot polydactyly (HP:0001830)1.81195708
146Renal cortical cysts (HP:0000803)1.81141867
147Hepatoblastoma (HP:0002884)1.80676251
148Scrotal hypoplasia (HP:0000046)1.80413926
149Abnormality of the ischium (HP:0003174)1.79196192
150Increased neuronal autofluorescent lipopigment (HP:0002074)1.77995935
151Congenital, generalized hypertrichosis (HP:0004540)1.77879686
152Abnormality of macular pigmentation (HP:0008002)1.77290845
153Fibular hypoplasia (HP:0003038)1.76983761
154Pulmonary embolism (HP:0002204)1.76073226
155Supernumerary spleens (HP:0009799)1.75719102
156Polyuria (HP:0000103)1.75286799
157Testicular neoplasm (HP:0010788)1.74519286
158Intellectual disability, moderate (HP:0002342)1.73741880
159Abnormality of alanine metabolism (HP:0010916)1.73051612
160Hyperalaninemia (HP:0003348)1.73051612
161Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.73051612
162Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.72917593
163Protruding tongue (HP:0010808)1.72864292
164Sprengel anomaly (HP:0000912)1.72769266
165Neonatal respiratory distress (HP:0002643)1.72488691
166Myelomeningocele (HP:0002475)1.72297143
167Cupped ear (HP:0000378)1.72225572
168Broad-based gait (HP:0002136)1.71601413
169Nephropathy (HP:0000112)1.71295350
170Peritonitis (HP:0002586)1.70155460
171Optic disc pallor (HP:0000543)1.69579144
172Optic nerve hypoplasia (HP:0000609)1.69307969
173Focal seizures (HP:0007359)1.68245351
174Vitreoretinal degeneration (HP:0000655)1.67868800
175Abnormality of the pleura (HP:0002103)1.67412512
176Abnormality of mucopolysaccharide metabolism (HP:0011020)1.67258431
177Abnormality of polysaccharide metabolism (HP:0011012)1.67258431
178Abnormality of glycosaminoglycan metabolism (HP:0004371)1.67258431
179Thyroiditis (HP:0100646)1.66942172
180Tetany (HP:0001281)1.66517040
181Absent speech (HP:0001344)1.66475464
182Renal agenesis (HP:0000104)1.66442694
183Concave nail (HP:0001598)1.66265839
184Decreased circulating renin level (HP:0003351)1.66180105
185Multicystic kidney dysplasia (HP:0000003)1.64380548

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK44.89653967
2MAPK154.16252773
3TIE13.64550277
4EPHA43.62278762
5CASK3.60553917
6SIK33.39926971
7KDR3.36791609
8PLK23.14492287
9MAP2K72.76031712
10BCKDK2.61984218
11CCNB12.59029472
12BLK2.22570876
13FGFR22.18926828
14NTRK32.15865973
15MUSK2.10428899
16SGK22.06891615
17PASK1.97604173
18TAOK31.91244837
19YES11.86613533
20MAP4K21.83553026
21BMPR1B1.82591934
22FES1.75692818
23TLK11.75033773
24STK161.71322297
25NUAK11.71042478
26BCR1.68450081
27TAOK21.66526441
28DAPK21.61914902
29CLK11.57337740
30TNIK1.53415178
31IRAK41.53156853
32MKNK11.45652673
33SGK4941.43763882
34SGK2231.43763882
35MAP3K41.39460532
36KIT1.38030323
37PRPF4B1.36290487
38FRK1.35847054
39DAPK11.34187112
40CSK1.25576650
41PINK11.24118863
42NTRK21.23814092
43ADRBK21.21438784
44CDK81.20828557
45TSSK61.16776076
46PLK31.16636766
47MAPK131.15783950
48EPHA31.11590949
49CDK191.11287070
50IKBKE1.09466309
51ERBB31.09141863
52PRKCG1.09034049
53NME11.08628323
54ITK1.07682120
55SGK31.07153309
56GRK11.06439418
57CDK31.04119152
58WNK41.02360348
59GRK61.02246888
60MINK11.01215569
61IKBKB0.99829663
62INSRR0.99547234
63IRAK10.97278892
64MAP4K10.97119096
65ACVR1B0.95303791
66TXK0.87527464
67MAP2K20.86483811
68NEK10.85928244
69EIF2AK20.85726476
70LYN0.85026422
71AKT30.84282457
72SYK0.83365303
73TYK20.83317032
74NEK60.82957009
75BRSK20.81150821
76MARK10.80991179
77WNK30.79659700
78BRSK10.79104772
79HIPK20.77881592
80ATR0.76127078
81PDK30.76099084
82PDK40.76099084
83BMPR20.75813349
84LCK0.72043529
85PRKCQ0.70115115
86TESK20.69997010
87FGR0.67703315
88VRK10.67407669
89RPS6KB10.67137126
90FER0.66770473
91PRKCZ0.66025190
92MAPKAPK50.64277065
93CAMK40.63161931
94TRPM70.62793642
95MARK20.62681174
96BTK0.62366683
97UHMK10.62171553
98SRPK10.62068796
99MATK0.61543522
100TGFBR10.61429141
101PIK3CA0.61406495
102PTK2B0.60168322
103OXSR10.57967352
104HCK0.57673120
105MAPK70.57497436
106SIK20.55874377
107PRKAA20.55291685
108PKN10.55217591
109PIK3CG0.55111385
110STK38L0.54240126
111TEC0.54001741
112MAP2K60.53437359
113MAP3K60.52966594
114MAP3K130.52314172
115NLK0.52086649
116CDK50.50928444
117KSR10.50594628
118SGK10.50308673
119MARK30.50266036
120MKNK20.49048896
121CHEK20.46989931
122TYRO30.45768076
123PRKG10.45712093
124DYRK1A0.44660212
125PRKCE0.44333029
126ABL10.43728873
127FGFR30.43111405
128ADRBK10.42952615
129CSF1R0.42661133
130EIF2AK30.42598163
131PAK30.42452918
132JAK30.41625683
133CAMKK20.41539985
134PRKACA0.41363686
135CAMK2A0.40848066
136DYRK1B0.40736777
137FGFR10.39815291
138MAP3K70.39476705
139CAMK10.38911927
140MAPK80.38604952
141BMX0.38595183
142PHKG20.36454350
143PHKG10.36454350
144CAMKK10.35726720
145PRKCH0.35409519
146MAP2K40.35203344
147STK390.34752099
148PRKACB0.32363677
149CDC70.32089730
150DYRK20.29883258
151TNK20.29871804
152CHUK0.29302112
153ZAK0.27772158
154EPHB20.27417356
155CDK10.26484170
156GSK3B0.24414075
157MAPK90.23385932
158STK110.22445312

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.65072454
2Morphine addiction_Homo sapiens_hsa050322.66022468
3Nitrogen metabolism_Homo sapiens_hsa009102.61417060
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.59579681
5Synaptic vesicle cycle_Homo sapiens_hsa047212.57468263
6Linoleic acid metabolism_Homo sapiens_hsa005912.53992709
7Olfactory transduction_Homo sapiens_hsa047402.49204243
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.46833748
9Maturity onset diabetes of the young_Homo sapiens_hsa049502.23900033
10Butanoate metabolism_Homo sapiens_hsa006502.22513993
11Vitamin B6 metabolism_Homo sapiens_hsa007502.05550517
12GABAergic synapse_Homo sapiens_hsa047272.04463015
13Oxidative phosphorylation_Homo sapiens_hsa001902.02723942
14Circadian entrainment_Homo sapiens_hsa047131.98340100
15Glutamatergic synapse_Homo sapiens_hsa047241.97704783
16Base excision repair_Homo sapiens_hsa034101.94292201
17Taste transduction_Homo sapiens_hsa047421.86346545
18Insulin secretion_Homo sapiens_hsa049111.80412145
19Tryptophan metabolism_Homo sapiens_hsa003801.71647542
20Histidine metabolism_Homo sapiens_hsa003401.70869693
21Mineral absorption_Homo sapiens_hsa049781.70797222
22Ovarian steroidogenesis_Homo sapiens_hsa049131.65625922
23DNA replication_Homo sapiens_hsa030301.64819784
24ABC transporters_Homo sapiens_hsa020101.60250454
25Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.59246879
26Primary immunodeficiency_Homo sapiens_hsa053401.55207852
27Allograft rejection_Homo sapiens_hsa053301.50193027
28Staphylococcus aureus infection_Homo sapiens_hsa051501.45699919
29Collecting duct acid secretion_Homo sapiens_hsa049661.45091380
30Homologous recombination_Homo sapiens_hsa034401.44774400
31Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.43768967
32Autoimmune thyroid disease_Homo sapiens_hsa053201.42584152
33Thyroid cancer_Homo sapiens_hsa052161.42428377
34Serotonergic synapse_Homo sapiens_hsa047261.41464737
35NOD-like receptor signaling pathway_Homo sapiens_hsa046211.36896810
36SNARE interactions in vesicular transport_Homo sapiens_hsa041301.33901162
37Axon guidance_Homo sapiens_hsa043601.33193744
38Fanconi anemia pathway_Homo sapiens_hsa034601.33165681
39Cell cycle_Homo sapiens_hsa041101.32254810
40Intestinal immune network for IgA production_Homo sapiens_hsa046721.31692098
41Parkinsons disease_Homo sapiens_hsa050121.31350385
42Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.29671923
43Graft-versus-host disease_Homo sapiens_hsa053321.27172902
44Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.25584203
45Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.25498543
46Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.23957483
47Salivary secretion_Homo sapiens_hsa049701.23537987
48Aldosterone synthesis and secretion_Homo sapiens_hsa049251.23240644
49Retinol metabolism_Homo sapiens_hsa008301.23026903
50Primary bile acid biosynthesis_Homo sapiens_hsa001201.17580472
51Asthma_Homo sapiens_hsa053101.16421195
52One carbon pool by folate_Homo sapiens_hsa006701.14742156
53Arachidonic acid metabolism_Homo sapiens_hsa005901.14676860
54Rheumatoid arthritis_Homo sapiens_hsa053231.14541529
55RNA polymerase_Homo sapiens_hsa030201.11500122
56Chemical carcinogenesis_Homo sapiens_hsa052041.11239715
57Melanogenesis_Homo sapiens_hsa049161.09157571
58Long-term potentiation_Homo sapiens_hsa047201.08701972
59Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.08474928
60Cholinergic synapse_Homo sapiens_hsa047251.07689828
61Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.07153471
62beta-Alanine metabolism_Homo sapiens_hsa004101.06487526
63Vibrio cholerae infection_Homo sapiens_hsa051101.06444133
64Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.05497253
65Cyanoamino acid metabolism_Homo sapiens_hsa004601.04397763
66Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.03839578
67Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.03686271
68Basal cell carcinoma_Homo sapiens_hsa052171.03543698
69GnRH signaling pathway_Homo sapiens_hsa049121.03262300
70Purine metabolism_Homo sapiens_hsa002300.99406464
71Calcium signaling pathway_Homo sapiens_hsa040200.99258152
72Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.99070284
73Non-homologous end-joining_Homo sapiens_hsa034500.98874429
74RNA degradation_Homo sapiens_hsa030180.96258603
75Transcriptional misregulation in cancer_Homo sapiens_hsa052020.96023254
76Steroid hormone biosynthesis_Homo sapiens_hsa001400.95781277
77Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.94655108
78Amphetamine addiction_Homo sapiens_hsa050310.94651333
79Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.94611387
80Phototransduction_Homo sapiens_hsa047440.94111608
81Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.93594692
82Spliceosome_Homo sapiens_hsa030400.93498463
83Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.92039882
84Oxytocin signaling pathway_Homo sapiens_hsa049210.91497850
85Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.88714292
86Long-term depression_Homo sapiens_hsa047300.87631883
87Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.86633144
88Peroxisome_Homo sapiens_hsa041460.85853790
89Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.84305708
90Glycosaminoglycan degradation_Homo sapiens_hsa005310.80132694
91Phagosome_Homo sapiens_hsa041450.80041305
92Dopaminergic synapse_Homo sapiens_hsa047280.79762038
93Hematopoietic cell lineage_Homo sapiens_hsa046400.79673347
94Type I diabetes mellitus_Homo sapiens_hsa049400.79633216
95Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.79356773
96N-Glycan biosynthesis_Homo sapiens_hsa005100.79300853
97Carbohydrate digestion and absorption_Homo sapiens_hsa049730.78395798
98Renin secretion_Homo sapiens_hsa049240.77192204
99Dorso-ventral axis formation_Homo sapiens_hsa043200.76601295
100Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.76393611
101Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.76379334
102Wnt signaling pathway_Homo sapiens_hsa043100.75708143
103Caffeine metabolism_Homo sapiens_hsa002320.75225405
104Gastric acid secretion_Homo sapiens_hsa049710.73365179
105Bile secretion_Homo sapiens_hsa049760.72835434
106Propanoate metabolism_Homo sapiens_hsa006400.71350701
107Notch signaling pathway_Homo sapiens_hsa043300.70701165
108Alzheimers disease_Homo sapiens_hsa050100.70028111
109cAMP signaling pathway_Homo sapiens_hsa040240.69679568
110Small cell lung cancer_Homo sapiens_hsa052220.69424704
111Glioma_Homo sapiens_hsa052140.69042362
112Glycerophospholipid metabolism_Homo sapiens_hsa005640.68962603
113Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.68860397
114Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.68545987
115Regulation of autophagy_Homo sapiens_hsa041400.66799486
116Thyroid hormone synthesis_Homo sapiens_hsa049180.66271642
117Non-small cell lung cancer_Homo sapiens_hsa052230.65442112
118Phenylalanine metabolism_Homo sapiens_hsa003600.65062508
119Fatty acid elongation_Homo sapiens_hsa000620.63544518
120Pyrimidine metabolism_Homo sapiens_hsa002400.62607590
121Glycerolipid metabolism_Homo sapiens_hsa005610.62296294
122Basal transcription factors_Homo sapiens_hsa030220.62042734
123Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.60210662
124Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.58842861
125Mismatch repair_Homo sapiens_hsa034300.58484550
126Lysine degradation_Homo sapiens_hsa003100.56518193
127Pentose and glucuronate interconversions_Homo sapiens_hsa000400.55498245
128Leishmaniasis_Homo sapiens_hsa051400.55195152
129Jak-STAT signaling pathway_Homo sapiens_hsa046300.53531367
130Huntingtons disease_Homo sapiens_hsa050160.53345686
131Dilated cardiomyopathy_Homo sapiens_hsa054140.51287591
132Osteoclast differentiation_Homo sapiens_hsa043800.51249702
133Vitamin digestion and absorption_Homo sapiens_hsa049770.50744783
134Antigen processing and presentation_Homo sapiens_hsa046120.50457835
135Starch and sucrose metabolism_Homo sapiens_hsa005000.49614147
136Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48910587
137Vascular smooth muscle contraction_Homo sapiens_hsa042700.48783109
138Gap junction_Homo sapiens_hsa045400.48370386
139Melanoma_Homo sapiens_hsa052180.47801204
140Arginine and proline metabolism_Homo sapiens_hsa003300.47229505
141Protein export_Homo sapiens_hsa030600.46769840
142Hedgehog signaling pathway_Homo sapiens_hsa043400.44938478
143Hippo signaling pathway_Homo sapiens_hsa043900.44318972
144Circadian rhythm_Homo sapiens_hsa047100.43493463
145Oocyte meiosis_Homo sapiens_hsa041140.42623913
146Malaria_Homo sapiens_hsa051440.42494465
147Cocaine addiction_Homo sapiens_hsa050300.42426658
148Lysosome_Homo sapiens_hsa041420.41883905
149Ether lipid metabolism_Homo sapiens_hsa005650.41729873
150Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.41596640
151Metabolic pathways_Homo sapiens_hsa011000.41294444
152Choline metabolism in cancer_Homo sapiens_hsa052310.39702853
153Thyroid hormone signaling pathway_Homo sapiens_hsa049190.39439720
154cGMP-PKG signaling pathway_Homo sapiens_hsa040220.39019324
155Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.38099867
156Fructose and mannose metabolism_Homo sapiens_hsa000510.37746042
157Type II diabetes mellitus_Homo sapiens_hsa049300.37057262
158African trypanosomiasis_Homo sapiens_hsa051430.36026201
159Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.35874824
160MAPK signaling pathway_Homo sapiens_hsa040100.34909471
161Ras signaling pathway_Homo sapiens_hsa040140.34853015
162Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.33596280
163Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.32681035
164p53 signaling pathway_Homo sapiens_hsa041150.32037972

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