CLEC18B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of male gonad development (GO:2000020)6.81720707
2negative regulation of metanephros development (GO:0072217)6.44862165
3metanephric mesenchyme development (GO:0072075)6.34415161
4negative regulation of mesenchymal cell apoptotic process (GO:2001054)6.29758932
5mesenchymal to epithelial transition (GO:0060231)6.16253430
6regulation of male gonad development (GO:2000018)5.65814145
7regulation of mesenchymal cell apoptotic process (GO:2001053)5.49673287
8glomerulus development (GO:0032835)5.40791355
9kidney mesenchyme development (GO:0072074)5.32459847
10cellular response to follicle-stimulating hormone stimulus (GO:0071372)5.32097328
11positive regulation of mesonephros development (GO:0061213)5.13429419
12cellular response to gonadotropin stimulus (GO:0071371)4.98135388
13skeletal muscle organ development (GO:0060538)4.78810061
14diaphragm development (GO:0060539)4.68948425
15regulation of mesonephros development (GO:0061217)4.63701528
16cardiac right ventricle morphogenesis (GO:0003215)4.60675784
17metanephric epithelium development (GO:0072207)4.35276029
18mesonephros development (GO:0001823)4.19501879
19seminiferous tubule development (GO:0072520)4.14535760
20neuronal stem cell maintenance (GO:0097150)4.12391725
21mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)4.00729724
22short-term memory (GO:0007614)3.97899860
23nephron tubule formation (GO:0072079)3.94327421
24lateral sprouting from an epithelium (GO:0060601)3.90981243
25pyrimidine nucleobase catabolic process (GO:0006208)3.90229410
26epithelial cell differentiation involved in kidney development (GO:0035850)3.84766480
27glomerular basement membrane development (GO:0032836)3.82653767
28limb bud formation (GO:0060174)3.80822291
29response to follicle-stimulating hormone (GO:0032354)3.76881939
30epithelial cell fate commitment (GO:0072148)3.72740654
31regulation of female gonad development (GO:2000194)3.65738066
32positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)3.62198874
33atrioventricular valve morphogenesis (GO:0003181)3.59980600
34negative regulation of kidney development (GO:0090185)3.57369434
35regulation of glomerulus development (GO:0090192)3.56109166
36sex determination (GO:0007530)3.53606477
37cell differentiation involved in kidney development (GO:0061005)3.52289197
38positive regulation of heart growth (GO:0060421)3.50584839
39negative regulation of macrophage differentiation (GO:0045650)3.44782352
40gamma-aminobutyric acid transport (GO:0015812)3.40340335
41nonmotile primary cilium assembly (GO:0035058)3.39281565
42eye photoreceptor cell differentiation (GO:0001754)3.38959742
43photoreceptor cell differentiation (GO:0046530)3.38959742
44positive regulation of metanephros development (GO:0072216)3.35488577
45parturition (GO:0007567)3.34462940
46regulation of branching involved in ureteric bud morphogenesis (GO:0090189)3.33186371
47regulation of gonadotropin secretion (GO:0032276)3.30985583
48otic vesicle formation (GO:0030916)3.30750756
49response to gonadotropin (GO:0034698)3.23045920
50male genitalia development (GO:0030539)3.22179592
51response to parathyroid hormone (GO:0071107)3.15925824
52regulation of cardioblast differentiation (GO:0051890)3.12359621
53negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.11677840
54calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.08936229
55presynaptic membrane assembly (GO:0097105)3.07958875
56SMAD protein signal transduction (GO:0060395)3.07836691
57axonal fasciculation (GO:0007413)3.04172186
58muscle cell fate commitment (GO:0042693)3.03773687
59embryonic foregut morphogenesis (GO:0048617)3.01573759
60embryonic digestive tract morphogenesis (GO:0048557)3.01109947
61retinal ganglion cell axon guidance (GO:0031290)2.99249464
62lens fiber cell development (GO:0070307)2.95364171
63neuron recognition (GO:0008038)2.93771665
64sequestering of actin monomers (GO:0042989)2.93515640
65cornea development in camera-type eye (GO:0061303)2.92871445
66regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.92849110
67neurotransmitter catabolic process (GO:0042135)2.89768768
68epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.89421044
69presynaptic membrane organization (GO:0097090)2.88721260
70camera-type eye morphogenesis (GO:0048593)2.86344024
71regulation of cell proliferation involved in kidney development (GO:1901722)2.85961952
72atrial septum morphogenesis (GO:0060413)2.83191335
73neuron fate determination (GO:0048664)2.83055348
74negative regulation of astrocyte differentiation (GO:0048712)2.80153788
75dopaminergic neuron differentiation (GO:0071542)2.78195022
76regulation of axon guidance (GO:1902667)2.73937974
77nucleobase catabolic process (GO:0046113)2.72382172
78regulation of metanephros development (GO:0072215)2.72316081
79positive regulation of kidney development (GO:0090184)2.69666771
80reproductive system development (GO:0061458)2.69410632
81spinal cord association neuron differentiation (GO:0021527)2.64169113
82cochlea morphogenesis (GO:0090103)2.63581473
83regulation of development, heterochronic (GO:0040034)2.62956446
84brain morphogenesis (GO:0048854)2.61756661
85endocardial cushion development (GO:0003197)2.58784246
86cell-cell junction maintenance (GO:0045217)2.55868629
87sex differentiation (GO:0007548)2.53701353
88cell differentiation involved in metanephros development (GO:0072202)2.53457644
89layer formation in cerebral cortex (GO:0021819)2.52361282
90olfactory bulb development (GO:0021772)2.51865251
91positive regulation of neuroblast proliferation (GO:0002052)2.51572332
92positive regulation of gastrulation (GO:2000543)2.51273821
93mesenchymal cell differentiation involved in renal system development (GO:2001012)2.51211327
94mesenchymal cell differentiation involved in kidney development (GO:0072161)2.51211327
95synaptic vesicle endocytosis (GO:0048488)2.50660004
96somite development (GO:0061053)2.50294474
97peripheral nervous system axon ensheathment (GO:0032292)2.49573092
98myelination in peripheral nervous system (GO:0022011)2.49573092
99specification of organ identity (GO:0010092)2.49495927
100neuron cell-cell adhesion (GO:0007158)2.49249769

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.11588498
2RBPJ_22232070_ChIP-Seq_NCS_Mouse4.22285727
3ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.61010599
4EZH2_27304074_Chip-Seq_ESCs_Mouse3.37138435
5CBX2_27304074_Chip-Seq_ESCs_Mouse2.91807593
6EED_16625203_ChIP-ChIP_MESCs_Mouse2.90694182
7NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.70308367
8SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.56484220
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.56457592
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.56457592
11PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.55058533
12RNF2_27304074_Chip-Seq_NSC_Mouse2.51320028
13JARID2_20064375_ChIP-Seq_MESCs_Mouse2.44992467
14GBX2_23144817_ChIP-Seq_PC3_Human2.40712244
15RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.24400580
16SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.10344597
17SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.09939320
18RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.09780999
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.09743498
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.08471687
21SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.05182189
22EZH2_27294783_Chip-Seq_ESCs_Mouse2.03594136
23JARID2_20075857_ChIP-Seq_MESCs_Mouse2.00309651
24RNF2_27304074_Chip-Seq_ESCs_Mouse1.98802975
25MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.88608484
26CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.83652038
27CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.81584778
28HIF1A_21447827_ChIP-Seq_MCF-7_Human1.80256172
29GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.78739195
30CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.77478286
31TP53_20018659_ChIP-ChIP_R1E_Mouse1.75913009
32RING1B_27294783_Chip-Seq_ESCs_Mouse1.72884540
33HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.71891070
34E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.65965802
35IGF1R_20145208_ChIP-Seq_DFB_Human1.64205430
36CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.57730987
37CTBP2_25329375_ChIP-Seq_LNCAP_Human1.56742661
38TAF15_26573619_Chip-Seq_HEK293_Human1.56338677
39MTF2_20144788_ChIP-Seq_MESCs_Mouse1.55534136
40ZNF274_21170338_ChIP-Seq_K562_Hela1.54787950
41EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.50426133
42BMI1_23680149_ChIP-Seq_NPCS_Mouse1.45295578
43ZFP57_27257070_Chip-Seq_ESCs_Mouse1.42634882
44VDR_22108803_ChIP-Seq_LS180_Human1.41592581
45CTBP1_25329375_ChIP-Seq_LNCAP_Human1.41285468
46OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.38269801
47PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.37593916
48SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.35460513
49TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.35042143
50RING1B_27294783_Chip-Seq_NPCs_Mouse1.34823392
51TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33050125
52KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.32132376
53REST_21632747_ChIP-Seq_MESCs_Mouse1.30960367
54REST_18959480_ChIP-ChIP_MESCs_Mouse1.29535537
55EWS_26573619_Chip-Seq_HEK293_Human1.28760322
56POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.28571093
57TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28571093
58MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.21881440
59SOX2_16153702_ChIP-ChIP_HESCs_Human1.17013829
60TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15150318
61THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.13456821
62TP63_19390658_ChIP-ChIP_HaCaT_Human1.13442760
63SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.13033966
64DROSHA_22980978_ChIP-Seq_HELA_Human1.11365598
65DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.09533285
66YAP1_20516196_ChIP-Seq_MESCs_Mouse1.08210381
67SMAD3_21741376_ChIP-Seq_EPCs_Human1.07257250
68GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.05537872
69PIAS1_25552417_ChIP-Seq_VCAP_Human1.04277848
70CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.03009175
71SOX3_22085726_ChIP-Seq_NPCs_Mouse0.98898721
72ISL1_27105846_Chip-Seq_CPCs_Mouse0.97337653
73POU5F1_16153702_ChIP-ChIP_HESCs_Human0.96913552
74SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.96826866
75WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.95563702
76GATA1_26923725_Chip-Seq_HPCs_Mouse0.94500641
77WT1_25993318_ChIP-Seq_PODOCYTE_Human0.92439909
78CDX2_19796622_ChIP-Seq_MESCs_Mouse0.92048817
79SMAD3_21741376_ChIP-Seq_ESCs_Human0.91556166
80MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.91555668
81STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.90999930
82ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.90528882
83SOX9_26525672_Chip-Seq_HEART_Mouse0.89578143
84LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89225558
85E2F1_17053090_ChIP-ChIP_MCF-7_Human0.88922589
86P300_19829295_ChIP-Seq_ESCs_Human0.88332833
87SOX2_21211035_ChIP-Seq_LN229_Gbm0.87642448
88SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.86803435
89TBX3_20139965_ChIP-Seq_ESCs_Mouse0.86553664
90TBX3_20139965_ChIP-Seq_MESCs_Mouse0.86413523
91FUS_26573619_Chip-Seq_HEK293_Human0.86142483
92CTCF_27219007_Chip-Seq_Bcells_Human0.84978271
93KDM2B_26808549_Chip-Seq_K562_Human0.84797937
94SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.83505739
95WDR5_24793694_ChIP-Seq_LNCAP_Human0.82373233
96EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.81640082
97SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.81032352
98SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.80924136
99AR_25329375_ChIP-Seq_VCAP_Human0.80625871
100P53_22127205_ChIP-Seq_FIBROBLAST_Human0.80351281

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis3.66788221
2MP0010030_abnormal_orbit_morphology2.82316201
3MP0000778_abnormal_nervous_system2.80702598
4MP0009384_cardiac_valve_regurgitation2.73314099
5MP0008995_early_reproductive_senescence2.71788426
6MP0005377_hearing/vestibular/ear_phenot2.60341400
7MP0003878_abnormal_ear_physiology2.60341400
8MP0003315_abnormal_perineum_morphology2.53948084
9MP0000537_abnormal_urethra_morphology2.46375337
10MP0003136_yellow_coat_color2.44468130
11MP0003942_abnormal_urinary_system2.10246705
12MP0003122_maternal_imprinting1.94011724
13MP0006276_abnormal_autonomic_nervous1.93227545
14MP0001293_anophthalmia1.87009747
15MP0002638_abnormal_pupillary_reflex1.86859860
16MP0002735_abnormal_chemical_nociception1.76312130
17MP0002736_abnormal_nociception_after1.73633133
18MP0004859_abnormal_synaptic_plasticity1.72980738
19MP0006292_abnormal_olfactory_placode1.72020932
20MP0005171_absent_coat_pigmentation1.65804429
21MP0000639_abnormal_adrenal_gland1.59312687
22MP0002697_abnormal_eye_size1.56365867
23MP0003121_genomic_imprinting1.55985730
24MP0005499_abnormal_olfactory_system1.55181716
25MP0005394_taste/olfaction_phenotype1.55181716
26MP0004885_abnormal_endolymph1.54739861
27MP0000026_abnormal_inner_ear1.50124660
28MP0006072_abnormal_retinal_apoptosis1.49959214
29MP0008877_abnormal_DNA_methylation1.49850711
30MP0001968_abnormal_touch/_nociception1.46802347
31MP0004142_abnormal_muscle_tone1.45849720
32MP0003938_abnormal_ear_development1.44633913
33MP0004742_abnormal_vestibular_system1.36760745
34MP0002653_abnormal_ependyma_morphology1.34874804
35MP0003011_delayed_dark_adaptation1.34226852
36MP0003123_paternal_imprinting1.32926275
37MP0003119_abnormal_digestive_system1.32335895
38MP0000516_abnormal_urinary_system1.32269146
39MP0005367_renal/urinary_system_phenotyp1.32269146
40MP0005253_abnormal_eye_physiology1.27162331
41MP0005391_vision/eye_phenotype1.26107370
42MP0001486_abnormal_startle_reflex1.25180437
43MP0003634_abnormal_glial_cell1.24974367
44MP0000049_abnormal_middle_ear1.24489059
45MP0005423_abnormal_somatic_nervous1.23650783
46MP0002557_abnormal_social/conspecific_i1.22635220
47MP0002063_abnormal_learning/memory/cond1.20280192
48MP0001286_abnormal_eye_development1.19553622
49MP0000631_abnormal_neuroendocrine_gland1.19549526
50MP0001984_abnormal_olfaction1.18608677
51MP0009745_abnormal_behavioral_response1.16121327
52MP0002092_abnormal_eye_morphology1.16019013
53MP0003937_abnormal_limbs/digits/tail_de1.15364391
54MP0005248_abnormal_Harderian_gland1.14688156
55MP0008789_abnormal_olfactory_epithelium1.14550802
56MP0001529_abnormal_vocalization1.14035856
57MP0001502_abnormal_circadian_rhythm1.13912675
58MP0002938_white_spotting1.13103053
59MP0004019_abnormal_vitamin_homeostasis1.12032482
60MP0002572_abnormal_emotion/affect_behav1.10703498
61MP0005195_abnormal_posterior_eye1.09830964
62MP0002882_abnormal_neuron_morphology1.09539089
63MP0001440_abnormal_grooming_behavior1.06907532
64MP0003283_abnormal_digestive_organ1.05925481
65MP0002909_abnormal_adrenal_gland1.05461777
66MP0002752_abnormal_somatic_nervous1.05041237
67MP0003880_abnormal_central_pattern1.04304900
68MP0003635_abnormal_synaptic_transmissio1.00792144
69MP0002067_abnormal_sensory_capabilities1.00704597
70MP0004270_analgesia0.98904534
71MP0001963_abnormal_hearing_physiology0.98256726
72MP0000955_abnormal_spinal_cord0.98008730
73MP0002282_abnormal_trachea_morphology0.97299826
74MP0003861_abnormal_nervous_system0.96648326
75MP0009053_abnormal_anal_canal0.96306443
76MP0005257_abnormal_intraocular_pressure0.95623080
77MP0000534_abnormal_ureter_morphology0.95234227
78MP0000579_abnormal_nail_morphology0.95167582
79MP0002152_abnormal_brain_morphology0.94703962
80MP0004133_heterotaxia0.91629282
81MP0004043_abnormal_pH_regulation0.91477683
82MP0003936_abnormal_reproductive_system0.90032966
83MP0002116_abnormal_craniofacial_bone0.89406951
84MP0002233_abnormal_nose_morphology0.89020833
85MP0002734_abnormal_mechanical_nocicepti0.88760755
86MP0005197_abnormal_uvea_morphology0.88483238
87MP0003567_abnormal_fetal_cardiomyocyte0.86627561
88MP0003755_abnormal_palate_morphology0.86491473
89MP0003221_abnormal_cardiomyocyte_apopto0.85944171
90MP0003828_pulmonary_edema0.85646979
91MP0002064_seizures0.84315394
92MP0000678_abnormal_parathyroid_gland0.84074115
93MP0002272_abnormal_nervous_system0.84046058
94MP0003632_abnormal_nervous_system0.83543083
95MP0005551_abnormal_eye_electrophysiolog0.83273899
96MP0003879_abnormal_hair_cell0.82899637
97MP0004811_abnormal_neuron_physiology0.82024145
98MP0002295_abnormal_pulmonary_circulatio0.81961888
99MP0000383_abnormal_hair_follicle0.80938009
100MP0002184_abnormal_innervation0.79036569

Predicted human phenotypes

RankGene SetZ-score
1Gonadal dysgenesis (HP:0000133)5.97392807
2Testicular neoplasm (HP:0010788)4.60658254
3Mesangial abnormality (HP:0001966)4.55094364
4Hypoplastic left heart (HP:0004383)4.49371547
5True hermaphroditism (HP:0010459)4.45660721
6Anomalous pulmonary venous return (HP:0010772)4.05255575
7Abnormal sex determination (HP:0012244)3.90793743
8Sex reversal (HP:0012245)3.90793743
9Degeneration of the lateral corticospinal tracts (HP:0002314)3.67875941
10Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.67875941
11Abnormality of the pulmonary veins (HP:0011718)3.49619350
12Hypoplastic heart (HP:0001961)3.44723053
13Turricephaly (HP:0000262)3.27263642
14Male pseudohermaphroditism (HP:0000037)3.22297792
15Transposition of the great arteries (HP:0001669)3.18626963
16Abnormal connection of the cardiac segments (HP:0011545)3.18626963
17Abnormal ventriculo-arterial connection (HP:0011563)3.18626963
18Vitreoretinal degeneration (HP:0000655)3.10840496
19Abnormality of the corticospinal tract (HP:0002492)2.89599917
20Preaxial foot polydactyly (HP:0001841)2.83784076
2111 pairs of ribs (HP:0000878)2.83203910
22Abnormality of the lower motor neuron (HP:0002366)2.66230632
23Neonatal short-limb short stature (HP:0008921)2.62938252
24Shoulder girdle muscle weakness (HP:0003547)2.55888025
25Coronal craniosynostosis (HP:0004440)2.50812572
26Primary adrenal insufficiency (HP:0008207)2.45364974
27Germ cell neoplasia (HP:0100728)2.41603010
28Nuclear cataract (HP:0100018)2.41556600
29Cholecystitis (HP:0001082)2.41048199
30Abnormal gallbladder physiology (HP:0012438)2.41048199
31High anterior hairline (HP:0009890)2.39835715
32Chronic hepatic failure (HP:0100626)2.38715225
33Male infertility (HP:0003251)2.35053654
34Genital tract atresia (HP:0001827)2.32435581
35Periauricular skin pits (HP:0100277)2.32074566
36Preauricular pit (HP:0004467)2.32074566
37Split foot (HP:0001839)2.31382402
38Type II lissencephaly (HP:0007260)2.31273381
39Aplasia involving bones of the upper limbs (HP:0009823)2.29984437
40Aplasia of the phalanges of the hand (HP:0009802)2.29984437
41Aplasia involving bones of the extremities (HP:0009825)2.29984437
42Vaginal atresia (HP:0000148)2.28063920
43Severe Myopia (HP:0011003)2.27837681
44Focal segmental glomerulosclerosis (HP:0000097)2.27228115
45Amblyopia (HP:0000646)2.26435387
46Partial agenesis of the corpus callosum (HP:0001338)2.25285157
47Retinal dysplasia (HP:0007973)2.23767906
48Gait imbalance (HP:0002141)2.21339677
49Abnormality of midbrain morphology (HP:0002418)2.20462702
50Molar tooth sign on MRI (HP:0002419)2.20462702
51Myokymia (HP:0002411)2.19007594
52Cutaneous finger syndactyly (HP:0010554)2.17845051
53Wide anterior fontanel (HP:0000260)2.16786273
54Abnormal respiratory epithelium morphology (HP:0012253)2.11251607
55Abnormal respiratory motile cilium morphology (HP:0005938)2.11251607
56Abnormal lung lobation (HP:0002101)2.10448077
57Abnormal ciliary motility (HP:0012262)2.08254880
58Fibular hypoplasia (HP:0003038)2.07692808
59Medial flaring of the eyebrow (HP:0010747)2.06394888
60Proximal tubulopathy (HP:0000114)2.02231435
61Nephronophthisis (HP:0000090)2.00515676
62Impaired vibration sensation in the lower limbs (HP:0002166)2.00332346
63Congenital diaphragmatic hernia (HP:0000776)1.99841812
64Congenital primary aphakia (HP:0007707)1.98980678
65Female pseudohermaphroditism (HP:0010458)1.97367482
66Abnormal respiratory motile cilium physiology (HP:0012261)1.97144370
67Nephrogenic diabetes insipidus (HP:0009806)1.96252414
68Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.96138417
69Occipital encephalocele (HP:0002085)1.95820503
70Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.95105190
71Short 4th metacarpal (HP:0010044)1.95105190
72Focal motor seizures (HP:0011153)1.90094034
73Trigonocephaly (HP:0000243)1.90005172
74Partial duplication of thumb phalanx (HP:0009944)1.89670978
75Hyperglycinemia (HP:0002154)1.85356114
76Keratoconus (HP:0000563)1.83303327
77Increased corneal curvature (HP:0100692)1.83303327
78Morphological abnormality of the middle ear (HP:0008609)1.83155331
79Intellectual disability, moderate (HP:0002342)1.82425663
80Abnormality of the labia minora (HP:0012880)1.81155239
81Abnormality of incisor morphology (HP:0011063)1.79528349
82Hypomagnesemia (HP:0002917)1.78692786
83Short tibia (HP:0005736)1.78637369
84Amyotrophic lateral sclerosis (HP:0007354)1.77971781
85Abnormality of the renal medulla (HP:0100957)1.77600528
86Megalencephaly (HP:0001355)1.77297166
87Cutaneous syndactyly (HP:0012725)1.76659294
88Pancreatic fibrosis (HP:0100732)1.76111923
89Duplication of thumb phalanx (HP:0009942)1.73126697
90Renal hypoplasia (HP:0000089)1.71803102
91Abnormality of glycolysis (HP:0004366)1.70571031
92Urinary bladder sphincter dysfunction (HP:0002839)1.70097024
93Bicornuate uterus (HP:0000813)1.69506261
94Paraplegia (HP:0010550)1.68131768
95Spastic paraplegia (HP:0001258)1.67517660
96Polyphagia (HP:0002591)1.67079987
97Tachypnea (HP:0002789)1.66790350
98Cerebellar dysplasia (HP:0007033)1.65496989
99Renal dysplasia (HP:0000110)1.64289518
100Aplasia/Hypoplasia of the fibula (HP:0006492)1.63536680

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.25981581
2MAPK153.23638799
3MARK13.21865636
4MAP3K43.04767477
5CASK3.02762577
6BCKDK2.89666066
7FGFR22.75094763
8EPHB22.65644751
9MAP2K72.54442645
10DYRK32.35737222
11TYRO32.30105640
12CDK192.07217520
13WNK32.05561819
14SIK22.03769771
15NEK91.61332578
16TNIK1.59301699
17SGK2231.58137365
18SGK4941.58137365
19PNCK1.57688252
20DYRK1A1.51058901
21DYRK1B1.45444371
22SGK21.44969100
23OXSR11.43813129
24UHMK11.43546055
25PLK21.42009792
26NTRK21.40856746
27IRAK11.35459767
28DYRK21.34710987
29EPHA41.25073169
30NTRK11.23739918
31ERBB31.22467417
32BCR1.21553772
33EPHA31.20653777
34KSR11.11252691
35WEE11.08684210
36MAP2K41.03604454
37ROCK21.00887083
38PKN11.00367148
39MAP2K60.98003608
40PINK10.95879959
41WNK40.93995603
42SGK10.93002546
43RPS6KA40.92256241
44CSNK1G20.86550806
45SRPK10.84962920
46PAK30.84763752
47MAPK130.84275813
48FGFR10.80921924
49PTK60.80888251
50CDK50.80265889
51EPHB10.79862315
52PRKCG0.79627094
53SGK30.79186326
54ADRBK20.78245051
55PLK40.77861259
56CDK30.76876667
57MOS0.76683118
58RPS6KL10.76107835
59RPS6KC10.76107835
60STK110.75882928
61RPS6KA20.75196379
62MINK10.74937941
63PAK60.73949259
64CSNK1G10.73562341
65MARK20.72340208
66FGR0.72155549
67RPS6KA60.71526578
68IRAK20.71321787
69ERBB20.71278471
70PASK0.71022998
71LRRK20.66973959
72CDK40.66727378
73BRD40.66647222
74CAMK2B0.64524277
75CDK11A0.64162533
76CDK150.60254152
77NME10.59232753
78MAPK100.58223933
79CDK180.57483037
80MAP3K70.55641935
81PRKCE0.52990521
82MAP4K20.52492857
83PIK3CA0.52244567
84CDK140.51049162
85PRKACA0.49429872
86CAMK2D0.45575901
87PRKAA10.44711655
88PRKG10.44014920
89PRKCZ0.43194710
90ROCK10.40229043
91YES10.40104854
92RPS6KA30.40084525
93SIK10.39343473
94MKNK10.37762341
95RET0.37610653
96PRKACG0.37246317
97CSNK1G30.37211628
98KSR20.35156884
99CAMK2G0.32582378
100CAMK2A0.31247214

Predicted pathways (KEGG)

RankGene SetZ-score
1Hedgehog signaling pathway_Homo sapiens_hsa043403.57962903
2Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.38327027
3Basal cell carcinoma_Homo sapiens_hsa052172.76624204
4Fatty acid elongation_Homo sapiens_hsa000622.44054229
5Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.02189964
6Cocaine addiction_Homo sapiens_hsa050301.92716861
7Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.87031166
8Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.86856226
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.86068002
10Oxidative phosphorylation_Homo sapiens_hsa001901.81989217
11Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.81584899
12Fructose and mannose metabolism_Homo sapiens_hsa000511.80248037
13Notch signaling pathway_Homo sapiens_hsa043301.80132610
14Butanoate metabolism_Homo sapiens_hsa006501.73556211
15Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.73500754
16Nicotine addiction_Homo sapiens_hsa050331.71107902
17Arginine and proline metabolism_Homo sapiens_hsa003301.65567090
18Protein export_Homo sapiens_hsa030601.61183883
19Axon guidance_Homo sapiens_hsa043601.58104277
20Propanoate metabolism_Homo sapiens_hsa006401.50776491
21Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.50391670
22Primary bile acid biosynthesis_Homo sapiens_hsa001201.46568176
23Nitrogen metabolism_Homo sapiens_hsa009101.43538775
24Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.40324635
25Parkinsons disease_Homo sapiens_hsa050121.38087571
26Circadian entrainment_Homo sapiens_hsa047131.36441268
27GABAergic synapse_Homo sapiens_hsa047271.35442566
28Huntingtons disease_Homo sapiens_hsa050161.29829344
29Cardiac muscle contraction_Homo sapiens_hsa042601.24068872
30Melanogenesis_Homo sapiens_hsa049161.21965193
31Hippo signaling pathway_Homo sapiens_hsa043901.18562144
32Glutamatergic synapse_Homo sapiens_hsa047241.17321814
33Wnt signaling pathway_Homo sapiens_hsa043101.11979146
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.11406411
35Carbon metabolism_Homo sapiens_hsa012001.09662420
36Alzheimers disease_Homo sapiens_hsa050101.09180820
37Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.07401822
38Morphine addiction_Homo sapiens_hsa050321.06668480
39Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.05745378
40Phototransduction_Homo sapiens_hsa047441.03458130
41Ribosome_Homo sapiens_hsa030101.00975706
42Protein digestion and absorption_Homo sapiens_hsa049741.00709937
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.99533662
44Dorso-ventral axis formation_Homo sapiens_hsa043200.98241816
45Cholinergic synapse_Homo sapiens_hsa047250.94988598
46Pentose phosphate pathway_Homo sapiens_hsa000300.92468501
47Ovarian steroidogenesis_Homo sapiens_hsa049130.92381178
48Gap junction_Homo sapiens_hsa045400.90353655
49Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.89927933
50ABC transporters_Homo sapiens_hsa020100.87195851
51Dopaminergic synapse_Homo sapiens_hsa047280.85104179
52Olfactory transduction_Homo sapiens_hsa047400.84357589
53Biosynthesis of amino acids_Homo sapiens_hsa012300.83805906
54Thyroid hormone synthesis_Homo sapiens_hsa049180.83129637
55Amphetamine addiction_Homo sapiens_hsa050310.78348774
56Steroid biosynthesis_Homo sapiens_hsa001000.77961249
57Collecting duct acid secretion_Homo sapiens_hsa049660.77155592
58Steroid hormone biosynthesis_Homo sapiens_hsa001400.76707679
59Insulin secretion_Homo sapiens_hsa049110.74298805
60Pyruvate metabolism_Homo sapiens_hsa006200.74238770
61Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.72312661
62RNA polymerase_Homo sapiens_hsa030200.72263710
63Bile secretion_Homo sapiens_hsa049760.71660191
64Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.70268314
65Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.68028520
66Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.68026949
67Gastric acid secretion_Homo sapiens_hsa049710.64947748
68Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.64890429
69Chemical carcinogenesis_Homo sapiens_hsa052040.63929664
70Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.63014244
71cAMP signaling pathway_Homo sapiens_hsa040240.62806680
72Circadian rhythm_Homo sapiens_hsa047100.60333203
73ECM-receptor interaction_Homo sapiens_hsa045120.59119579
74Vibrio cholerae infection_Homo sapiens_hsa051100.58072524
75Lysine degradation_Homo sapiens_hsa003100.57124935
76Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.56719598
77TGF-beta signaling pathway_Homo sapiens_hsa043500.54966777
78Tryptophan metabolism_Homo sapiens_hsa003800.53475745
79Synaptic vesicle cycle_Homo sapiens_hsa047210.53156471
80Peroxisome_Homo sapiens_hsa041460.52681717
81Glutathione metabolism_Homo sapiens_hsa004800.52001116
82Fanconi anemia pathway_Homo sapiens_hsa034600.50545078
83Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.50306239
84Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.50144606
85HIF-1 signaling pathway_Homo sapiens_hsa040660.49810901
86Metabolic pathways_Homo sapiens_hsa011000.48338480
87Serotonergic synapse_Homo sapiens_hsa047260.48192740
88Prion diseases_Homo sapiens_hsa050200.45760012
89Rap1 signaling pathway_Homo sapiens_hsa040150.45257970
90Starch and sucrose metabolism_Homo sapiens_hsa005000.43722658
91Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.42860672
92Retinol metabolism_Homo sapiens_hsa008300.42533722
93Taste transduction_Homo sapiens_hsa047420.41698452
94Pathways in cancer_Homo sapiens_hsa052000.40878050
95Calcium signaling pathway_Homo sapiens_hsa040200.40009619
96Vitamin digestion and absorption_Homo sapiens_hsa049770.36427330
97Fatty acid metabolism_Homo sapiens_hsa012120.36333932
98Oocyte meiosis_Homo sapiens_hsa041140.36091180
99Ether lipid metabolism_Homo sapiens_hsa005650.35232491
100Cyanoamino acid metabolism_Homo sapiens_hsa004600.34831870

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