CLEC19A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.83582508
2axonemal dynein complex assembly (GO:0070286)8.10302156
3cilium or flagellum-dependent cell motility (GO:0001539)8.05519460
4cilium movement (GO:0003341)8.03695599
5epithelial cilium movement (GO:0003351)7.25159470
6ribosomal small subunit assembly (GO:0000028)6.89195657
7regulation of phospholipid biosynthetic process (GO:0071071)6.30709592
8intraciliary transport (GO:0042073)6.16755331
9viral transcription (GO:0019083)5.95636268
10sequestering of actin monomers (GO:0042989)5.88254016
11maturation of SSU-rRNA (GO:0030490)5.83890134
12artery smooth muscle contraction (GO:0014824)5.78549260
13translational termination (GO:0006415)5.57890549
14lateral sprouting from an epithelium (GO:0060601)5.45156057
15detection of temperature stimulus (GO:0016048)5.31431572
16nonmotile primary cilium assembly (GO:0035058)5.25338917
17prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060525.24642418
18serotonin receptor signaling pathway (GO:0007210)5.19731466
19otic vesicle formation (GO:0030916)5.18220599
20ventricular system development (GO:0021591)5.00588774
21tonic smooth muscle contraction (GO:0014820)4.98664701
22SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.92201642
23cotranslational protein targeting to membrane (GO:0006613)4.89837300
24motile cilium assembly (GO:0044458)4.89013981
25protein targeting to ER (GO:0045047)4.79929442
26regulation of cilium movement (GO:0003352)4.78030863
27craniofacial suture morphogenesis (GO:0097094)4.70398550
28intra-S DNA damage checkpoint (GO:0031573)4.70297810
29regulation of appetite (GO:0032098)4.64920216
30regulation of branching involved in prostate gland morphogenesis (GO:0060687)4.62781368
31establishment of protein localization to endoplasmic reticulum (GO:0072599)4.57566422
32translational elongation (GO:0006414)4.50123387
33short-term memory (GO:0007614)4.49213974
34midbrain development (GO:0030901)4.46609070
35protein localization to endoplasmic reticulum (GO:0070972)4.44305139
36cranial suture morphogenesis (GO:0060363)4.36538626
37cilium assembly (GO:0042384)4.25458727
38cGMP biosynthetic process (GO:0006182)4.22126404
39limb bud formation (GO:0060174)4.19830601
40cilium organization (GO:0044782)4.16805220
41cellular protein complex disassembly (GO:0043624)4.13960330
42nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.07517645
43neuron fate determination (GO:0048664)4.06928482
44viral life cycle (GO:0019058)4.02072566
45striatum development (GO:0021756)3.96324119
46branching involved in labyrinthine layer morphogenesis (GO:0060670)3.96150346
47vascular smooth muscle contraction (GO:0014829)3.94941942
48protein localization to cytoskeleton (GO:0044380)3.94790169
49regulation of non-canonical Wnt signaling pathway (GO:2000050)3.93398777
50G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.92056291
51left/right pattern formation (GO:0060972)3.91565229
52cilium morphogenesis (GO:0060271)3.91080833
53lung lobe morphogenesis (GO:0060463)3.85690050
54prostate gland growth (GO:0060736)3.84646437
55mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.74991181
56imidazole-containing compound metabolic process (GO:0052803)3.70913584
57translational initiation (GO:0006413)3.67316786
58inner mitochondrial membrane organization (GO:0007007)3.66311055
59sleep (GO:0030431)3.59136883
60behavioral response to cocaine (GO:0048148)3.55318940
61lens fiber cell development (GO:0070307)3.54660640
62negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.48096051
63protein complex disassembly (GO:0043241)3.45764688
64detection of temperature stimulus involved in sensory perception (GO:0050961)3.43600742
65detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.43600742
66urinary tract smooth muscle contraction (GO:0014848)3.42705868
67epithelial cell differentiation involved in prostate gland development (GO:0060742)3.40991248
68G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.40348721
69mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.36861177
70respiratory electron transport chain (GO:0022904)3.28682561
71thalamus development (GO:0021794)3.28617208
72energy coupled proton transport, down electrochemical gradient (GO:0015985)3.27910652
73ATP synthesis coupled proton transport (GO:0015986)3.27910652
74axoneme assembly (GO:0035082)3.25541090
75electron transport chain (GO:0022900)3.23146132
76regulation of microtubule-based movement (GO:0060632)3.23039056
77macromolecular complex disassembly (GO:0032984)3.18656269
78determination of left/right symmetry (GO:0007368)3.17243220
79protein targeting to membrane (GO:0006612)3.15277003
80negative regulation of appetite (GO:0032099)3.12716697
81negative regulation of response to food (GO:0032096)3.12716697
82neuronal stem cell maintenance (GO:0097150)3.12047500
83DNA integration (GO:0015074)3.11052798
84positive regulation of TOR signaling (GO:0032008)3.08648623
85lung-associated mesenchyme development (GO:0060484)3.05574127
86determination of bilateral symmetry (GO:0009855)3.03519695
87cellular component assembly involved in morphogenesis (GO:0010927)3.02604267
88photoreceptor cell differentiation (GO:0046530)3.00200676
89eye photoreceptor cell differentiation (GO:0001754)3.00200676
90serine family amino acid catabolic process (GO:0009071)2.99525580
91regulation of hair follicle development (GO:0051797)2.98436075
92specification of symmetry (GO:0009799)2.97797140
93myoblast fusion (GO:0007520)2.95768036
94axon extension involved in axon guidance (GO:0048846)2.95416429
95neuron projection extension involved in neuron projection guidance (GO:1902284)2.95416429
96photoreceptor cell maintenance (GO:0045494)2.91974505
97neural tube formation (GO:0001841)2.89075383
98mesenchymal cell proliferation (GO:0010463)2.88470465
99smoothened signaling pathway (GO:0007224)2.87960881
100branching involved in salivary gland morphogenesis (GO:0060445)2.76247829

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZFP322A_24550733_ChIP-Seq_MESCs_Mouse4.39912899
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.16431118
3GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse4.08193686
4GBX2_23144817_ChIP-Seq_PC3_Human4.02000292
5PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.79598643
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.44460800
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.14837573
8STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.01661967
9CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.88215014
10TAF15_26573619_Chip-Seq_HEK293_Human2.74395442
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.57451776
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.50620170
13FUS_26573619_Chip-Seq_HEK293_Human2.49759454
14EZH2_22144423_ChIP-Seq_EOC_Human2.45301146
15GATA1_22025678_ChIP-Seq_K562_Human2.39291981
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.26247478
17P300_19829295_ChIP-Seq_ESCs_Human2.23103570
18CTBP1_25329375_ChIP-Seq_LNCAP_Human2.07530224
19CTBP2_25329375_ChIP-Seq_LNCAP_Human1.92887113
20TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.77320920
21LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.75078581
22CBX2_27304074_Chip-Seq_ESCs_Mouse1.74967796
23NR3C1_21868756_ChIP-Seq_MCF10A_Human1.71115178
24MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.67280985
25GABP_17652178_ChIP-ChIP_JURKAT_Human1.66874174
26SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.61369134
27PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.58838236
28NANOG_18555785_Chip-Seq_ESCs_Mouse1.57309468
29SMAD4_21799915_ChIP-Seq_A2780_Human1.55906054
30TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.50324759
31PIAS1_25552417_ChIP-Seq_VCAP_Human1.49450761
32AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.49244682
33POU5F1_16153702_ChIP-ChIP_HESCs_Human1.47688878
34STAT3_23295773_ChIP-Seq_U87_Human1.46404712
35CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.46280778
36EWS_26573619_Chip-Seq_HEK293_Human1.45789906
37SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.45441805
38IGF1R_20145208_ChIP-Seq_DFB_Human1.45143739
39RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.44859449
40TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42253839
41POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.42253839
42LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40655431
43OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38447062
44RBPJ_22232070_ChIP-Seq_NCS_Mouse1.38217593
45TAL1_26923725_Chip-Seq_HPCs_Mouse1.37842679
46E2F1_18555785_Chip-Seq_ESCs_Mouse1.36635310
47NR3C1_23031785_ChIP-Seq_PC12_Mouse1.34313262
48SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.32736135
49EST1_17652178_ChIP-ChIP_JURKAT_Human1.28330225
50SMAD3_21741376_ChIP-Seq_EPCs_Human1.27856955
51AR_25329375_ChIP-Seq_VCAP_Human1.27139986
52CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.26822170
53TCF4_23295773_ChIP-Seq_U87_Human1.26719179
54VDR_22108803_ChIP-Seq_LS180_Human1.26597960
55SOX2_21211035_ChIP-Seq_LN229_Gbm1.25668817
56ELK1_19687146_ChIP-ChIP_HELA_Human1.25025101
57UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24075359
58CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.23907461
59HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.21959939
60MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.21758430
61SOX2_16153702_ChIP-ChIP_HESCs_Human1.21213223
62FLI1_27457419_Chip-Seq_LIVER_Mouse1.19926307
63CBP_20019798_ChIP-Seq_JUKART_Human1.18787539
64IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.18787539
65ESR1_20079471_ChIP-ChIP_T-47D_Human1.17849733
66P300_18555785_Chip-Seq_ESCs_Mouse1.17137192
67EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.15689981
68SUZ12_27294783_Chip-Seq_NPCs_Mouse1.13534864
69TOP2B_26459242_ChIP-Seq_MCF-7_Human1.12840156
70RNF2_27304074_Chip-Seq_NSC_Mouse1.10792967
71FOXM1_26456572_ChIP-Seq_MCF-7_Human1.09723987
72SALL1_21062744_ChIP-ChIP_HESCs_Human1.07534414
73BCAT_22108803_ChIP-Seq_LS180_Human1.06297979
74CMYC_18555785_Chip-Seq_ESCs_Mouse1.05922630
75STAT3_18555785_Chip-Seq_ESCs_Mouse1.05786833
76NFYA_21822215_ChIP-Seq_K562_Human1.05594025
77ER_23166858_ChIP-Seq_MCF-7_Human1.04063526
78VDR_23849224_ChIP-Seq_CD4+_Human1.03427769
79NFE2_27457419_Chip-Seq_LIVER_Mouse1.01024287
80PCGF2_27294783_Chip-Seq_ESCs_Mouse0.99908515
81RUNX2_22187159_ChIP-Seq_PCA_Human0.99069415
82RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.98459214
83P53_22387025_ChIP-Seq_ESCs_Mouse0.95857641
84SUZ12_18555785_Chip-Seq_ESCs_Mouse0.95554440
85ZFX_18555785_Chip-Seq_ESCs_Mouse0.95138432
86YAP1_20516196_ChIP-Seq_MESCs_Mouse0.95131336
87SOX9_26525672_Chip-Seq_HEART_Mouse0.94833021
88TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.94735975
89LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93825621
90EZH2_27304074_Chip-Seq_ESCs_Mouse0.93584928
91NANOG_19829295_ChIP-Seq_ESCs_Human0.93390434
92SOX2_19829295_ChIP-Seq_ESCs_Human0.93390434
93SOX2_18555785_Chip-Seq_ESCs_Mouse0.93381626
94SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.92925815
95KLF5_20875108_ChIP-Seq_MESCs_Mouse0.92837758
96EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.91536240
97ESRRB_18555785_Chip-Seq_ESCs_Mouse0.91503766
98SMAD1_18555785_Chip-Seq_ESCs_Mouse0.91457778
99KLF4_18555785_Chip-Seq_ESCs_Mouse0.90929161
100TBL1_22424771_ChIP-Seq_293T_Human0.90046634

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis6.58791294
2MP0010030_abnormal_orbit_morphology6.22180129
3MP0002653_abnormal_ependyma_morphology4.33379322
4MP0000372_irregular_coat_pigmentation3.52135962
5MP0000537_abnormal_urethra_morphology2.99848394
6MP0000569_abnormal_digit_pigmentation2.85035137
7MP0005394_taste/olfaction_phenotype2.81258528
8MP0005499_abnormal_olfactory_system2.81258528
9MP0008789_abnormal_olfactory_epithelium2.55471227
10MP0000383_abnormal_hair_follicle2.51642524
11MP0001984_abnormal_olfaction2.50263507
12MP0003136_yellow_coat_color2.35863790
13MP0004142_abnormal_muscle_tone2.30288513
14MP0001346_abnormal_lacrimal_gland2.17252301
15MP0002233_abnormal_nose_morphology2.13812671
16MP0002295_abnormal_pulmonary_circulatio2.09236352
17MP0003011_delayed_dark_adaptation2.05947290
18MP0005377_hearing/vestibular/ear_phenot1.99073504
19MP0003878_abnormal_ear_physiology1.99073504
20MP0008961_abnormal_basal_metabolism1.94602868
21MP0001485_abnormal_pinna_reflex1.93846119
22MP0002282_abnormal_trachea_morphology1.82079641
23MP0005248_abnormal_Harderian_gland1.73457070
24MP0000579_abnormal_nail_morphology1.70481965
25MP0003890_abnormal_embryonic-extraembry1.70204854
26MP0002938_white_spotting1.67903689
27MP0001293_anophthalmia1.67195018
28MP0005171_absent_coat_pigmentation1.62876912
29MP0005423_abnormal_somatic_nervous1.60357006
30MP0001324_abnormal_eye_pigmentation1.58271889
31MP0005623_abnormal_meninges_morphology1.53889755
32MP0003283_abnormal_digestive_organ1.51692224
33MP0006292_abnormal_olfactory_placode1.50786753
34MP0000026_abnormal_inner_ear1.50614706
35MP0000462_abnormal_digestive_system1.46946625
36MP0009379_abnormal_foot_pigmentation1.44317771
37MP0010678_abnormal_skin_adnexa1.44016793
38MP0002736_abnormal_nociception_after1.40944168
39MP0006072_abnormal_retinal_apoptosis1.38017917
40MP0000778_abnormal_nervous_system1.37335379
41MP0003879_abnormal_hair_cell1.31816710
42MP0008995_early_reproductive_senescence1.29058964
43MP0004147_increased_porphyrin_level1.28902434
44MP0005253_abnormal_eye_physiology1.25536687
45MP0002234_abnormal_pharynx_morphology1.21735327
46MP0003937_abnormal_limbs/digits/tail_de1.19035501
47MP0001440_abnormal_grooming_behavior1.18931880
48MP0003938_abnormal_ear_development1.17765681
49MP0003806_abnormal_nucleotide_metabolis1.16433949
50MP0000647_abnormal_sebaceous_gland1.15169305
51MP0005551_abnormal_eye_electrophysiolog1.12294334
52MP0002102_abnormal_ear_morphology1.12193001
53MP0002184_abnormal_innervation1.12025023
54MP0001177_atelectasis1.11206095
55MP0002638_abnormal_pupillary_reflex1.09049348
56MP0001501_abnormal_sleep_pattern1.08245119
57MP0009046_muscle_twitch1.07279644
58MP0003880_abnormal_central_pattern1.06296993
59MP0000049_abnormal_middle_ear1.05891868
60MP0001299_abnormal_eye_distance/1.04654806
61MP0000631_abnormal_neuroendocrine_gland1.03108204
62MP0005195_abnormal_posterior_eye0.99030938
63MP0002090_abnormal_vision0.94326668
64MP0002751_abnormal_autonomic_nervous0.93469848
65MP0003119_abnormal_digestive_system0.91261156
66MP0004043_abnormal_pH_regulation0.86899428
67MP0002332_abnormal_exercise_endurance0.85853081
68MP0005391_vision/eye_phenotype0.85302974
69MP0001286_abnormal_eye_development0.85129480
70MP0004133_heterotaxia0.82341192
71MP0005197_abnormal_uvea_morphology0.81708780
72MP0005266_abnormal_metabolism0.80675081
73MP0004742_abnormal_vestibular_system0.78628881
74MP0005367_renal/urinary_system_phenotyp0.76129756
75MP0000516_abnormal_urinary_system0.76129756
76MP0002572_abnormal_emotion/affect_behav0.72728748
77MP0002752_abnormal_somatic_nervous0.72000209
78MP0005174_abnormal_tail_pigmentation0.71739168
79MP0003959_abnormal_lean_body0.71694787
80MP0009703_decreased_birth_body0.70521739
81MP0005388_respiratory_system_phenotype0.69715491
82MP0002133_abnormal_respiratory_system0.69715491
83MP0009250_abnormal_appendicular_skeleto0.64691885
84MP0002064_seizures0.62544095
85MP0003755_abnormal_palate_morphology0.62519492
86MP0000432_abnormal_head_morphology0.62326130
87MP0002882_abnormal_neuron_morphology0.62198995
88MP0003195_calcinosis0.61718109
89MP0002067_abnormal_sensory_capabilities0.61373022
90MP0005075_abnormal_melanosome_morpholog0.59054533
91MP0001963_abnormal_hearing_physiology0.57538837
92MP0002111_abnormal_tail_morphology0.57416671
93MP0003122_maternal_imprinting0.56688467
94MP0000428_abnormal_craniofacial_morphol0.54603090
95MP0002108_abnormal_muscle_morphology0.53473713
96MP0002092_abnormal_eye_morphology0.53097451
97MP0002089_abnormal_postnatal_growth/wei0.52325551
98MP0000955_abnormal_spinal_cord0.52076780
99MP0001486_abnormal_startle_reflex0.51089195
100MP0003634_abnormal_glial_cell0.49867943

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)8.85452428
2Abnormal ciliary motility (HP:0012262)5.55285404
3Abnormal respiratory motile cilium physiology (HP:0012261)5.55091590
4Rhinitis (HP:0012384)5.45400944
5Occipital encephalocele (HP:0002085)4.45918761
6Pancreatic fibrosis (HP:0100732)4.27926383
7Abnormal respiratory motile cilium morphology (HP:0005938)3.94409529
8Abnormal respiratory epithelium morphology (HP:0012253)3.94409529
9Bell-shaped thorax (HP:0001591)3.86222722
10Dynein arm defect of respiratory motile cilia (HP:0012255)3.85714387
11Absent/shortened dynein arms (HP:0200106)3.85714387
12Abnormal biliary tract physiology (HP:0012439)3.84963962
13Bile duct proliferation (HP:0001408)3.84963962
14Broad metatarsal (HP:0001783)3.81258934
15True hermaphroditism (HP:0010459)3.65178794
16Gait imbalance (HP:0002141)3.59207270
17Chronic bronchitis (HP:0004469)3.54039624
18Tubular atrophy (HP:0000092)3.53452418
19Nasal polyposis (HP:0100582)3.52433785
20Abnormal number of erythroid precursors (HP:0012131)3.50708246
21Congenital primary aphakia (HP:0007707)3.50599790
22Chronic hepatic failure (HP:0100626)3.47975378
23Abnormal drinking behavior (HP:0030082)3.44205549
24Polydipsia (HP:0001959)3.44205549
25Medial flaring of the eyebrow (HP:0010747)3.41582471
26Vaginal atresia (HP:0000148)3.40106990
27Genital tract atresia (HP:0001827)3.35257055
28Abnormality of cells of the erythroid lineage (HP:0012130)3.34392429
29Recurrent sinusitis (HP:0011108)3.26802014
30Pancreatic cysts (HP:0001737)3.22446314
31Nephronophthisis (HP:0000090)3.15141582
32Nephrogenic diabetes insipidus (HP:0009806)3.09724538
33Split foot (HP:0001839)3.01986135
34Chronic otitis media (HP:0000389)2.97676131
35Abnormality of the labia minora (HP:0012880)2.97242580
36Abnormality of midbrain morphology (HP:0002418)2.97158768
37Molar tooth sign on MRI (HP:0002419)2.97158768
38Partial duplication of thumb phalanx (HP:0009944)2.91613368
39Aplasia involving bones of the extremities (HP:0009825)2.89031946
40Aplasia involving bones of the upper limbs (HP:0009823)2.89031946
41Aplasia of the phalanges of the hand (HP:0009802)2.89031946
42Abnormality of the phalanges of the 2nd finger (HP:0009541)2.85556359
43Trigonocephaly (HP:0000243)2.83383639
44Stenosis of the external auditory canal (HP:0000402)2.81141858
45Poor coordination (HP:0002370)2.79121260
46Cystic liver disease (HP:0006706)2.77993332
47Abnormality of the nasal mucosa (HP:0000433)2.77638714
48Hyperglycinemia (HP:0002154)2.74272269
49Bronchiectasis (HP:0002110)2.70919044
50Broad distal phalanx of finger (HP:0009836)2.67437402
51Abnormality of the middle phalanges of the toes (HP:0010183)2.66783727
52Turricephaly (HP:0000262)2.62935124
53Coronal craniosynostosis (HP:0004440)2.52359950
54Cutaneous finger syndactyly (HP:0010554)2.50383336
55Partial duplication of the phalanx of hand (HP:0009999)2.49948307
56Stomach cancer (HP:0012126)2.46072113
57Anteriorly placed anus (HP:0001545)2.45355886
58Abnormality of the renal medulla (HP:0100957)2.44955297
59Anencephaly (HP:0002323)2.43373660
60Intellectual disability, moderate (HP:0002342)2.42825751
61Abnormality of the renal cortex (HP:0011035)2.39355703
62Abnormality of the parietal bone (HP:0002696)2.37946295
63Aplasia/Hypoplasia of the tongue (HP:0010295)2.37424842
64Hypoplastic labia majora (HP:0000059)2.31950277
65Congenital hepatic fibrosis (HP:0002612)2.28517380
66Esophageal atresia (HP:0002032)2.26946773
67Short nail (HP:0001799)2.24301967
68Polyuria (HP:0000103)2.23567489
69Sclerocornea (HP:0000647)2.22582065
70Nasolacrimal duct obstruction (HP:0000579)2.20843851
71Abnormality of incisor morphology (HP:0011063)2.14252581
72Cutaneous syndactyly (HP:0012725)2.10038122
73Abnormality of the labia majora (HP:0012881)2.07436852
74Polyphagia (HP:0002591)2.06682704
75Preaxial foot polydactyly (HP:0001841)2.05618131
76Aplasia/Hypoplasia of the lens (HP:0008063)2.05435544
77Bronchitis (HP:0012387)2.04439266
78Duplication of thumb phalanx (HP:0009942)2.03247682
79Abnormality of permanent molar morphology (HP:0011071)1.99817264
80Abnormality of the dental root (HP:0006486)1.99817264
81Taurodontia (HP:0000679)1.99817264
82Diastasis recti (HP:0001540)1.97909988
83Anophthalmia (HP:0000528)1.96706958
84Postaxial hand polydactyly (HP:0001162)1.95082878
85Abnormality of the lacrimal duct (HP:0011481)1.94999294
86Vitreoretinal degeneration (HP:0000655)1.89654038
87Abnormal urine output (HP:0012590)1.88642806
88Postaxial foot polydactyly (HP:0001830)1.84434637
89Humeroradial synostosis (HP:0003041)1.83005226
90Synostosis involving the elbow (HP:0003938)1.83005226
91Preaxial hand polydactyly (HP:0001177)1.80447318
92Broad foot (HP:0001769)1.78901940
93Alacrima (HP:0000522)1.78792434
94Abnormality of molar morphology (HP:0011070)1.78501197
95Abnormality of molar (HP:0011077)1.78501197
96Macrocytic anemia (HP:0001972)1.77977315
97Broad toe (HP:0001837)1.77530049
98Bifid tongue (HP:0010297)1.73815412
99Recurrent otitis media (HP:0000403)1.73383860
100Abnormality of the dental pulp (HP:0006479)1.73181480

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FGFR26.85106491
2TLK13.26400457
3MAP3K123.23899706
4MAP3K43.12672289
5EPHA43.09966996
6MAP4K22.96751502
7CDK192.78669370
8MAPK152.76692809
9INSRR2.47609173
10ZAK2.45255676
11BCKDK2.20465289
12TYRO32.17281201
13PASK2.14879686
14STK38L2.05637965
15CASK2.01187197
16TGFBR11.94668457
17MAP2K41.82447929
18DDR21.75002303
19EPHB21.73514342
20STK241.63624484
21MAP2K71.57808354
22FGFR11.54838094
23MET1.45427448
24PRKD31.41980509
25GRK71.33497225
26FGR1.32828271
27BMX1.31839662
28PTK2B1.27324821
29NTRK21.24049792
30MATK1.22359160
31MARK11.19959126
32VRK11.14871590
33TAOK31.11666296
34LMTK21.04124663
35BMPR1B0.98916244
36CDK80.95902062
37WNK30.91401966
38SGK20.91283433
39ADRBK20.89951429
40PRKG20.89619235
41PNCK0.87546265
42LRRK20.82972236
43PLK20.81865917
44CAMK1G0.81762264
45SGK4940.79816942
46SGK2230.79816942
47PRKCG0.75191221
48CDK30.73613396
49DMPK0.71470878
50MAPK130.70086009
51WNK40.66413878
52MAP3K50.66211703
53STK30.65524071
54MAP3K60.63405479
55DYRK1B0.56990683
56MAPK70.56740147
57BLK0.55414055
58ABL20.54187030
59MST40.53284715
60CSF1R0.51610708
61DYRK1A0.51344522
62NEK90.51171683
63DYRK30.48000792
64CHUK0.47666062
65PKN10.47560033
66PRKACB0.46111099
67VRK20.45752667
68CAMK40.45739594
69CDK90.45632911
70MAP3K110.44595756
71MUSK0.42691052
72SGK10.39210733
73PRKACA0.39045913
74PDGFRB0.37036993
75SGK30.35418409
76DAPK30.34757735
77MKNK10.34506208
78PRKG10.33553362
79PRKCE0.33527391
80STK160.31594634
81ADRBK10.28517455
82CDK50.27000720
83PRKCD0.26235461
84IKBKB0.25099131
85MOS0.24891815
86OXSR10.24851437
87CAMK2G0.23295884
88PRKCQ0.22018525
89MAP3K100.21768194
90ERBB20.21539563
91CSNK1G20.21212197
92RPS6KA50.20942659
93CSNK1A10.20671456
94PLK30.20500695
95CAMK10.20251655
96CAMK2A0.20091528
97STK390.19364099
98RPS6KA30.18608347
99RET0.18227187
100INSR0.17539527

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.24555612
2Oxidative phosphorylation_Homo sapiens_hsa001905.23637756
3Parkinsons disease_Homo sapiens_hsa050123.89222167
4Huntingtons disease_Homo sapiens_hsa050163.70007609
5Alzheimers disease_Homo sapiens_hsa050103.21078068
6Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.83843606
7Cardiac muscle contraction_Homo sapiens_hsa042602.62293500
8One carbon pool by folate_Homo sapiens_hsa006702.59315705
9Primary bile acid biosynthesis_Homo sapiens_hsa001202.58482968
10Systemic lupus erythematosus_Homo sapiens_hsa053222.26732787
11Basal cell carcinoma_Homo sapiens_hsa052172.14851132
12Hedgehog signaling pathway_Homo sapiens_hsa043402.01028768
13Protein export_Homo sapiens_hsa030601.88461811
14Nicotine addiction_Homo sapiens_hsa050331.77568732
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.73674447
16RNA polymerase_Homo sapiens_hsa030201.69801332
17Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.67540541
18Propanoate metabolism_Homo sapiens_hsa006401.65553877
19Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.49176967
20Alcoholism_Homo sapiens_hsa050341.42425312
21Nitrogen metabolism_Homo sapiens_hsa009101.29248557
22Proteasome_Homo sapiens_hsa030501.23707674
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.20237061
24Lysosome_Homo sapiens_hsa041421.09637494
25Rheumatoid arthritis_Homo sapiens_hsa053231.05768641
26Collecting duct acid secretion_Homo sapiens_hsa049661.05207304
27Ovarian steroidogenesis_Homo sapiens_hsa049131.03513925
28Mineral absorption_Homo sapiens_hsa049781.00479782
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.96886002
30Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.93707277
31N-Glycan biosynthesis_Homo sapiens_hsa005100.93115355
32Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.91860246
33Glutathione metabolism_Homo sapiens_hsa004800.91807779
34Fanconi anemia pathway_Homo sapiens_hsa034600.91359577
35Vitamin digestion and absorption_Homo sapiens_hsa049770.90228115
36Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.84015137
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.80920789
38Malaria_Homo sapiens_hsa051440.80230645
39Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.79923978
40Steroid hormone biosynthesis_Homo sapiens_hsa001400.79095658
41Nucleotide excision repair_Homo sapiens_hsa034200.78946240
42RNA degradation_Homo sapiens_hsa030180.78183462
43Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.76830448
44Histidine metabolism_Homo sapiens_hsa003400.76660273
45Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.76179141
46Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.76022327
47Tryptophan metabolism_Homo sapiens_hsa003800.75273502
48Phototransduction_Homo sapiens_hsa047440.72985184
49NOD-like receptor signaling pathway_Homo sapiens_hsa046210.72051343
50Serotonergic synapse_Homo sapiens_hsa047260.71830371
51Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.67589861
52Metabolic pathways_Homo sapiens_hsa011000.65498981
53Basal transcription factors_Homo sapiens_hsa030220.64252915
54Gap junction_Homo sapiens_hsa045400.62910677
55Peroxisome_Homo sapiens_hsa041460.62035615
56Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.61851134
57Fatty acid elongation_Homo sapiens_hsa000620.60932613
58Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.59848809
59Phagosome_Homo sapiens_hsa041450.59457074
60Tyrosine metabolism_Homo sapiens_hsa003500.58954849
61Circadian entrainment_Homo sapiens_hsa047130.58602808
62Linoleic acid metabolism_Homo sapiens_hsa005910.55713243
63Glutamatergic synapse_Homo sapiens_hsa047240.55177945
64Maturity onset diabetes of the young_Homo sapiens_hsa049500.55107731
65TGF-beta signaling pathway_Homo sapiens_hsa043500.54608646
66Bile secretion_Homo sapiens_hsa049760.52574794
67Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.52117031
68Steroid biosynthesis_Homo sapiens_hsa001000.51849787
69Arachidonic acid metabolism_Homo sapiens_hsa005900.50481184
70Folate biosynthesis_Homo sapiens_hsa007900.50464626
71Staphylococcus aureus infection_Homo sapiens_hsa051500.49298907
72Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.48685299
73Chemical carcinogenesis_Homo sapiens_hsa052040.46983567
74Pyruvate metabolism_Homo sapiens_hsa006200.46948944
75Mismatch repair_Homo sapiens_hsa034300.46749675
76Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.42537388
77Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.41860001
78Melanogenesis_Homo sapiens_hsa049160.41137192
79Thyroid hormone synthesis_Homo sapiens_hsa049180.40423366
80Homologous recombination_Homo sapiens_hsa034400.40417582
81Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.39425402
82Hippo signaling pathway_Homo sapiens_hsa043900.39296495
83Sphingolipid metabolism_Homo sapiens_hsa006000.38606470
84Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.38509346
85Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.37527199
86Calcium signaling pathway_Homo sapiens_hsa040200.37278868
87GABAergic synapse_Homo sapiens_hsa047270.35173989
88Notch signaling pathway_Homo sapiens_hsa043300.33075535
89Glycerolipid metabolism_Homo sapiens_hsa005610.33023271
90Purine metabolism_Homo sapiens_hsa002300.32976321
91ABC transporters_Homo sapiens_hsa020100.30665155
92Taste transduction_Homo sapiens_hsa047420.28921864
93Asthma_Homo sapiens_hsa053100.28481717
94Pertussis_Homo sapiens_hsa051330.27794096
95Arginine and proline metabolism_Homo sapiens_hsa003300.25449666
96Viral carcinogenesis_Homo sapiens_hsa052030.25293876
97Cocaine addiction_Homo sapiens_hsa050300.25194357
98Vitamin B6 metabolism_Homo sapiens_hsa007500.24881114
99Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.24781231
100Axon guidance_Homo sapiens_hsa043600.23693956

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