CLEC1B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Natural killer (NK) cells express multiple calcium-dependent (C-type) lectin-like receptors, such as CD94 (KLRD1; MIM 602894) and NKG2D (KLRC4; MIM 602893), that interact with major histocompatibility complex class I molecules and either inhibit or activate cytotoxicity and cytokine secretion. CLEC2 is a C-type lectin-like receptor expressed in myeloid cells and NK cells (Colonna et al., 2000 [PubMed 10671229]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1thrombin receptor signaling pathway (GO:0070493)7.00497257
2protein neddylation (GO:0045116)6.59280996
3leukocyte migration involved in inflammatory response (GO:0002523)6.03601381
4regulation of platelet aggregation (GO:0090330)5.62498496
5regulation of platelet activation (GO:0010543)5.43533488
6intra-S DNA damage checkpoint (GO:0031573)5.28701354
7angiogenesis involved in wound healing (GO:0060055)5.24621653
8regulation of DNA endoreduplication (GO:0032875)5.18354026
9peptidyl-glutamic acid carboxylation (GO:0017187)5.08381376
10protein carboxylation (GO:0018214)5.08381376
11triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.96908305
12positive regulation of respiratory burst (GO:0060267)4.95205937
13L-phenylalanine catabolic process (GO:0006559)4.92692897
14erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.92692897
15positive regulation of mast cell activation (GO:0033005)4.72612163
16neutrophil activation (GO:0042119)4.68508076
17L-phenylalanine metabolic process (GO:0006558)4.66345272
18erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.66345272
19platelet aggregation (GO:0070527)4.65296147
20regulation of integrin-mediated signaling pathway (GO:2001044)4.57372817
21hydrogen peroxide biosynthetic process (GO:0050665)4.57311615
22adenosine receptor signaling pathway (GO:0001973)4.55975468
23regulation of metalloenzyme activity (GO:0048552)4.47860877
24aromatic amino acid family catabolic process (GO:0009074)4.45762675
25positive regulation of triglyceride lipase activity (GO:0061365)4.41519513
26positive regulation of lipoprotein lipase activity (GO:0051006)4.41519513
27synapsis (GO:0007129)4.40085752
28negative regulation of fibrinolysis (GO:0051918)4.32821099
29high-density lipoprotein particle remodeling (GO:0034375)4.26715804
30negative regulation of homotypic cell-cell adhesion (GO:0034111)4.21469326
31negative regulation of platelet activation (GO:0010544)4.16385281
32negative regulation of thymocyte apoptotic process (GO:0070244)4.14751995
33granulocyte activation (GO:0036230)4.14012685
34regulation of fibrinolysis (GO:0051917)4.12364502
35bile acid biosynthetic process (GO:0006699)4.11966229
36G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)4.11774085
37negative regulation of norepinephrine secretion (GO:0010700)4.06212474
38reactive oxygen species biosynthetic process (GO:1903409)4.05387761
39negative regulation of macrophage derived foam cell differentiation (GO:0010745)4.05347218
40urea metabolic process (GO:0019627)4.02025588
41urea cycle (GO:0000050)4.02025588
42positive regulation of cAMP-mediated signaling (GO:0043950)4.01374582
43glyoxylate metabolic process (GO:0046487)4.01146160
44indole-containing compound catabolic process (GO:0042436)4.00521847
45indolalkylamine catabolic process (GO:0046218)4.00521847
46tryptophan catabolic process (GO:0006569)4.00521847
47lipoxygenase pathway (GO:0019372)4.00042599
48phospholipid efflux (GO:0033700)3.93824356
49plasma lipoprotein particle clearance (GO:0034381)3.91340928
50complement activation, alternative pathway (GO:0006957)3.91230069
51reverse cholesterol transport (GO:0043691)3.91122285
52aldehyde catabolic process (GO:0046185)3.90477587
53purinergic nucleotide receptor signaling pathway (GO:0035590)3.90096951
54regulation of cholesterol esterification (GO:0010872)3.89817913
55positive regulation of protein autophosphorylation (GO:0031954)3.87231218
56plasma lipoprotein particle remodeling (GO:0034369)3.86879836
57protein-lipid complex remodeling (GO:0034368)3.86879836
58macromolecular complex remodeling (GO:0034367)3.86879836
59negative regulation of heart rate (GO:0010459)3.86496019
60fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.82864128
61tryptophan metabolic process (GO:0006568)3.82665072
62negative regulation of calcium ion transport into cytosol (GO:0010523)3.79228312
63negative regulation of nitric-oxide synthase activity (GO:0051001)3.78922839
64fibrinolysis (GO:0042730)3.78803161
65telomere maintenance via telomerase (GO:0007004)3.78601949
66kynurenine metabolic process (GO:0070189)3.77247993
67regulation of protein activation cascade (GO:2000257)3.73919612
68positive regulation of macrophage differentiation (GO:0045651)3.72338829
69regulation of triglyceride catabolic process (GO:0010896)3.67015671
70blood coagulation, intrinsic pathway (GO:0007597)3.65721134
71cysteine metabolic process (GO:0006534)3.64445877
72nitrogen cycle metabolic process (GO:0071941)3.63776084
73positive regulation of endothelial cell differentiation (GO:0045603)3.63351621
74antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.62742394
75regulation of integrin activation (GO:0033623)3.61686201
76platelet degranulation (GO:0002576)3.59962551
77regulation of mast cell activation (GO:0033003)3.59851266
78megakaryocyte development (GO:0035855)3.59087053
79alpha-linolenic acid metabolic process (GO:0036109)3.57846443
80regulation of MHC class II biosynthetic process (GO:0045346)3.55980156
81positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.54310479
82low-density lipoprotein particle remodeling (GO:0034374)3.50996997
83mitotic G2 DNA damage checkpoint (GO:0007095)3.48802571
84regulation of complement activation (GO:0030449)3.44908082
85cholesterol efflux (GO:0033344)3.42963996
86positive regulation of hemostasis (GO:1900048)3.42489216
87positive regulation of blood coagulation (GO:0030194)3.42489216
88leukocyte degranulation (GO:0043299)3.42401639
89cofactor catabolic process (GO:0051187)3.42097461
90arginine metabolic process (GO:0006525)3.41207397
91bile acid metabolic process (GO:0008206)3.40609187
92acute-phase response (GO:0006953)3.40445052
93positive regulation of mast cell activation involved in immune response (GO:0033008)3.35608100
94positive regulation of mast cell degranulation (GO:0043306)3.35608100
95positive regulation of lipid catabolic process (GO:0050996)3.35602508
96regulation of mast cell activation involved in immune response (GO:0033006)3.35106948
97homotypic cell-cell adhesion (GO:0034109)3.34469592
98platelet activation (GO:0030168)3.34202367
99regulation of Golgi to plasma membrane protein transport (GO:0042996)3.31512698
100positive regulation of systemic arterial blood pressure (GO:0003084)3.30316849
101regulation of homotypic cell-cell adhesion (GO:0034110)3.30300492
102positive regulation of receptor recycling (GO:0001921)3.29842537
103regulation of mast cell degranulation (GO:0043304)3.29369094
104acylglycerol homeostasis (GO:0055090)3.29274108
105triglyceride homeostasis (GO:0070328)3.29274108
106purinergic receptor signaling pathway (GO:0035587)3.28783448
107negative regulation of T-helper cell differentiation (GO:0045623)3.28287663
108negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.28287663
109positive regulation of coagulation (GO:0050820)3.24426272
110regulation of lipoprotein metabolic process (GO:0050746)3.23018205
111homocysteine metabolic process (GO:0050667)3.22499798
112amino-acid betaine metabolic process (GO:0006577)3.21881416
113respiratory burst (GO:0045730)3.20944745
114negative regulation of hemostasis (GO:1900047)3.19591853
115negative regulation of blood coagulation (GO:0030195)3.19591853
116tyrosine metabolic process (GO:0006570)3.18197500
117regulation of B cell receptor signaling pathway (GO:0050855)3.17451477
118cholesterol homeostasis (GO:0042632)3.17137262
119fusion of sperm to egg plasma membrane (GO:0007342)3.17136573
120sulfur amino acid catabolic process (GO:0000098)3.15004607
121sterol homeostasis (GO:0055092)3.12663083
122negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.11814115
123G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.11674906
124negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.11479361
125regulation of macrophage derived foam cell differentiation (GO:0010743)3.11225316
126negative regulation of sterol transport (GO:0032372)3.11022070
127negative regulation of cholesterol transport (GO:0032375)3.11022070
128negative regulation of coagulation (GO:0050819)3.10192097
129protein activation cascade (GO:0072376)3.09398647
130regulation of memory T cell differentiation (GO:0043380)3.09368003
131phospholipid homeostasis (GO:0055091)3.08564402
132protein-lipid complex assembly (GO:0065005)3.08499571
133aromatic amino acid family metabolic process (GO:0009072)3.07463113
134negative regulation of protein localization to cell surface (GO:2000009)3.07158444
135negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)3.07079958
136neutrophil activation involved in immune response (GO:0002283)3.06580172
137RNA-dependent DNA replication (GO:0006278)3.05979796
138cellular response to cadmium ion (GO:0071276)3.05578045
139regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.05485646
140myeloid cell activation involved in immune response (GO:0002275)3.05021166
141beta-amyloid metabolic process (GO:0050435)3.04919490
142negative regulation of response to food (GO:0032096)3.04855276
143negative regulation of appetite (GO:0032099)3.04855276
144protein-lipid complex subunit organization (GO:0071825)3.04853078
145microglial cell activation (GO:0001774)3.02971858
146cholesterol transport (GO:0030301)3.02871985
147sterol transport (GO:0015918)3.02871985
148positive regulation of cellular amide metabolic process (GO:0034250)3.01491907
149phagocytosis, recognition (GO:0006910)3.00852310
150Arp2/3 complex-mediated actin nucleation (GO:0034314)3.00597084
151platelet dense granule organization (GO:0060155)3.00521617
152response to folic acid (GO:0051593)3.00129865
153peptide catabolic process (GO:0043171)2.98606315
154negative regulation of T cell apoptotic process (GO:0070233)2.98413030
155superoxide anion generation (GO:0042554)2.97451910
156plasma lipoprotein particle organization (GO:0071827)2.97286439
157NAD biosynthetic process (GO:0009435)2.96196402
158plasma lipoprotein particle assembly (GO:0034377)2.95240850
159response to nitrosative stress (GO:0051409)2.94690472
160regulation of cholesterol storage (GO:0010885)2.94646911
161regulation of hemostasis (GO:1900046)2.93734106
162regulation of blood coagulation (GO:0030193)2.93734106
163autophagic vacuole fusion (GO:0000046)2.93326159
164positive regulation of granulocyte differentiation (GO:0030854)2.93011776
165opsonization (GO:0008228)2.92445345
166endothelium development (GO:0003158)2.92421429
167regulation of regulatory T cell differentiation (GO:0045589)2.92048658
168regulation of appetite (GO:0032098)2.92042387
169negative regulation of heart contraction (GO:0045822)2.90415821
170positive regulation of Rho protein signal transduction (GO:0035025)2.85021704
171negative regulation of interleukin-17 production (GO:0032700)2.84830103
172polyamine biosynthetic process (GO:0006596)2.82978809
173phagocytosis, engulfment (GO:0006911)2.81114679
174termination of G-protein coupled receptor signaling pathway (GO:0038032)2.78322796
175mucosal immune response (GO:0002385)2.77216948
176regulation of cholesterol efflux (GO:0010874)2.75543818
177termination of signal transduction (GO:0023021)2.74055312
178extracellular fibril organization (GO:0043206)2.73326444
179positive regulation of B cell mediated immunity (GO:0002714)2.72270595
180positive regulation of immunoglobulin mediated immune response (GO:0002891)2.72270595
181activated T cell proliferation (GO:0050798)2.71377278
182regulation of norepinephrine secretion (GO:0014061)2.69799315
183regulation of inositol phosphate biosynthetic process (GO:0010919)2.69682263
184negative regulation of neural precursor cell proliferation (GO:2000178)2.68783849
185pyrimidine nucleoside catabolic process (GO:0046135)2.68300228
186cellular extravasation (GO:0045123)2.67925589
187regulation of coagulation (GO:0050818)2.64651728
188organ or tissue specific immune response (GO:0002251)2.64452668

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.59852989
2RXR_22158963_ChIP-Seq_LIVER_Mouse5.63378455
3EGR1_23403033_ChIP-Seq_LIVER_Mouse4.95936879
4LXR_22158963_ChIP-Seq_LIVER_Mouse4.44272645
5PPARA_22158963_ChIP-Seq_LIVER_Mouse4.42077915
6IRF8_22096565_ChIP-ChIP_GC-B_Human3.69526437
7BP1_19119308_ChIP-ChIP_Hs578T_Human3.49768683
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.43252169
9FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.41711142
10PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.19472399
11IRF8_21731497_ChIP-ChIP_J774_Mouse3.01661652
12GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.91832507
13Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.87255257
14CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.59717205
15SPI1_23127762_ChIP-Seq_K562_Human2.58778681
16GBX2_23144817_ChIP-Seq_PC3_Human2.45766114
17TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.43363710
18NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.40823879
19* IRF8_27001747_Chip-Seq_BMDM_Mouse2.36110756
20FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.35093771
21* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.28392913
22SCL_19346495_ChIP-Seq_HPC-7_Human2.26097279
23IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.06293146
24IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.05975434
25GATA2_21666600_ChIP-Seq_HMVEC_Human2.01776635
26THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.01361919
27RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.94190081
28TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.90744660
29PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.83188486
30HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.79187762
31NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.77027641
32GATA1_22383799_ChIP-Seq_G1ME_Mouse1.72008111
33EZH2_22144423_ChIP-Seq_EOC_Human1.71671068
34MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.71341650
35CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.71277588
36STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.68960268
37RUNX1_22412390_ChIP-Seq_EML_Mouse1.68956143
38* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.68700308
39MYB_21317192_ChIP-Seq_ERMYB_Mouse1.67267315
40STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.66049468
41ELK4_26923725_Chip-Seq_MESODERM_Mouse1.60744779
42GATA1_22025678_ChIP-Seq_K562_Human1.54985335
43FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.53821886
44HTT_18923047_ChIP-ChIP_STHdh_Human1.48456907
45SRY_22984422_ChIP-ChIP_TESTIS_Rat1.43646152
46GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43317189
47TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.42658079
48ESR1_20079471_ChIP-ChIP_T-47D_Human1.41719513
49IGF1R_20145208_ChIP-Seq_DFB_Human1.41579323
50NRF2_20460467_ChIP-Seq_MEFs_Mouse1.40806278
51NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.40806278
52GATA1_19941827_ChIP-Seq_MEL86_Mouse1.40262095
53SPI1_23547873_ChIP-Seq_NB4_Human1.37282019
54KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.30775018
55HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.27648218
56VDR_24787735_ChIP-Seq_THP-1_Human1.24246431
57CDX2_19796622_ChIP-Seq_MESCs_Mouse1.21780743
58RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.21323754
59GATA2_22383799_ChIP-Seq_G1ME_Mouse1.20441457
60VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.20213122
61POU3F2_20337985_ChIP-ChIP_501MEL_Human1.19800837
62BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.18759080
63STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.18094700
64GATA2_19941826_ChIP-Seq_K562_Human1.17176543
65MYB_26560356_Chip-Seq_TH2_Human1.16739695
66RUNX_20019798_ChIP-Seq_JUKART_Human1.14439349
67PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14286829
68GATA3_27048872_Chip-Seq_THYMUS_Human1.13761746
69CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12493731
70SALL4_18804426_ChIP-ChIP_XEN_Mouse1.12068299
71IRF1_19129219_ChIP-ChIP_H3396_Human1.11669414
72SALL4_22934838_ChIP-ChIP_CD34+_Human1.10533320
73CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.09811342
74STAT4_19710469_ChIP-ChIP_TH1__Mouse1.08436199
75SMAD_19615063_ChIP-ChIP_OVARY_Human1.06775198
76FOXA2_19822575_ChIP-Seq_HepG2_Human1.03958020
77LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.03421910
78ETS1_22383799_ChIP-Seq_G1ME_Mouse1.02892051
79E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.02327496
80NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.01993237
81CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01660986
82FLI1_27457419_Chip-Seq_LIVER_Mouse1.01419023
83BRD4_27068464_Chip-Seq_AML-cells_Mouse1.01196594
84GATA3_26560356_Chip-Seq_TH2_Human1.00737187
85PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00286949
86VDR_24763502_ChIP-Seq_THP-1_Human1.00100599
87RARG_19884340_ChIP-ChIP_MEFs_Mouse0.99791415
88SOX2_20726797_ChIP-Seq_SW620_Human0.99342511
89TRIM28_21343339_ChIP-Seq_HEK293_Human0.98963561
90SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.98565147
91STAT1_20625510_ChIP-Seq_HELA_Human0.98534602
92GATA1_19941827_ChIP-Seq_MEL_Mouse0.98335164
93UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.96712540
94GATA1_19941826_ChIP-Seq_K562_Human0.95860051
95PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.95270379
96EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.94317728
97EZH2_27294783_Chip-Seq_NPCs_Mouse0.94273011
98UTX_26944678_Chip-Seq_JUKART_Human0.93707414
99MYB_26560356_Chip-Seq_TH1_Human0.93088026
100GATA3_21878914_ChIP-Seq_MCF-7_Human0.92286553
101OCT4_21477851_ChIP-Seq_ESCs_Mouse0.89331454
102ER_23166858_ChIP-Seq_MCF-7_Human0.88074377
103AR_25329375_ChIP-Seq_VCAP_Human0.87461068
104TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.87435161
105FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.87182000
106OCT1_27270436_Chip-Seq_PROSTATE_Human0.86983262
107SMRT_27268052_Chip-Seq_Bcells_Human0.85617324
108CJUN_26792858_Chip-Seq_BT549_Human0.85369231
109MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.85208301
110JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.83305980
111IKZF1_21737484_ChIP-ChIP_HCT116_Human0.82283786
112CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.81441780
113GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.81030530
114JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.80502698
115CRX_20693478_ChIP-Seq_RETINA_Mouse0.80385573
116TP53_16413492_ChIP-PET_HCT116_Human0.80340921
117NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.80289077
118NCOR1_26117541_ChIP-Seq_K562_Human0.80001607
119VDR_22108803_ChIP-Seq_LS180_Human0.79589058
120PU_27001747_Chip-Seq_BMDM_Mouse0.79538282
121AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.78757346
122FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.78502496
123PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.77767469
124GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.77723487
125CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.77648386
126BCAT_22108803_ChIP-Seq_LS180_Human0.77421919
127FLI1_21867929_ChIP-Seq_TH2_Mouse0.76987225
128TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.76245580
129ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.76029109
130CEBPB_22108803_ChIP-Seq_LS180_Human0.75725864
131LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.75293034
132ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.74939755
133CDX2_20551321_ChIP-Seq_CACO-2_Human0.74771892
134CLOCK_20551151_ChIP-Seq_293T_Human0.74375864
135TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.74092983
136GATA4_25053715_ChIP-Seq_YYC3_Human0.73732519
137LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.71415836
138PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.70156628
139SPI1_20517297_ChIP-Seq_HL60_Human0.70142899
140NFIB_24661679_ChIP-Seq_LUNG_Mouse0.69943416
141AR_20517297_ChIP-Seq_VCAP_Human0.69158154
142HNF4A_19822575_ChIP-Seq_HepG2_Human0.69107772
143PPAR_26484153_Chip-Seq_NCI-H1993_Human0.69100170
144MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.68281332
145TAF15_26573619_Chip-Seq_HEK293_Human0.67623240
146ERG_20517297_ChIP-Seq_VCAP_Human0.66977422
147RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.66265956
148ESR1_21235772_ChIP-Seq_MCF-7_Human0.65482929
149EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.64962585
150* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.62796944
151ELK3_25401928_ChIP-Seq_HUVEC_Human0.61489105
152SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.61485473
153AUTS2_25519132_ChIP-Seq_293T-REX_Human0.60751035

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis7.91676193
2MP0003191_abnormal_cellular_cholesterol5.15949655
3MP0002139_abnormal_hepatobiliary_system4.69004296
4MP0008004_abnormal_stomach_pH4.48620914
5MP0005085_abnormal_gallbladder_physiolo3.68969943
6MP0000465_gastrointestinal_hemorrhage3.10110870
7MP0008875_abnormal_xenobiotic_pharmacok3.05830126
8MP0005365_abnormal_bile_salt3.05791208
9MP0010368_abnormal_lymphatic_system2.70920199
10MP0009780_abnormal_chondrocyte_physiolo2.69337438
11MP0003705_abnormal_hypodermis_morpholog2.57071346
12MP0004510_myositis2.36316952
13MP0009840_abnormal_foam_cell2.32870876
14MP0002396_abnormal_hematopoietic_system2.30458376
15MP0003724_increased_susceptibility_to2.28826334
16MP0005167_abnormal_blood-brain_barrier2.27842922
17MP0003950_abnormal_plasma_membrane2.23723511
18MP0003252_abnormal_bile_duct2.22686990
19MP0001853_heart_inflammation2.20858089
20MP0003183_abnormal_peptide_metabolism1.96915384
21MP0010329_abnormal_lipoprotein_level1.95417279
22MP0009785_altered_susceptibility_to1.95207993
23MP0002332_abnormal_exercise_endurance1.93891274
24* MP0001879_abnormal_lymphatic_vessel1.92608742
25MP0005058_abnormal_lysosome_morphology1.89603350
26MP0003436_decreased_susceptibility_to1.81065460
27MP0001851_eye_inflammation1.76001301
28MP0009764_decreased_sensitivity_to1.75584571
29MP0003638_abnormal_response/metabolism_1.74419163
30MP0005084_abnormal_gallbladder_morpholo1.74110579
31MP0003806_abnormal_nucleotide_metabolis1.71352252
32MP0002138_abnormal_hepatobiliary_system1.69648553
33MP0003828_pulmonary_edema1.69335789
34MP0003566_abnormal_cell_adhesion1.67027239
35MP0002736_abnormal_nociception_after1.63467379
36MP0003075_altered_response_to1.62632395
37MP0004084_abnormal_cardiac_muscle1.61691927
38* MP0002398_abnormal_bone_marrow1.59791144
39MP0004130_abnormal_muscle_cell1.59506796
40MP0002132_abnormal_respiratory_system1.57677002
41MP0002419_abnormal_innate_immunity1.57094961
42MP0001835_abnormal_antigen_presentation1.55674285
43* MP0000230_abnormal_systemic_arterial1.55500551
44MP0005083_abnormal_biliary_tract1.48894788
45MP0004782_abnormal_surfactant_physiolog1.44576815
46MP0004883_abnormal_blood_vessel1.43638135
47* MP0005464_abnormal_platelet_physiology1.41435328
48MP0005410_abnormal_fertilization1.41163888
49MP0005332_abnormal_amino_acid1.40417417
50MP0003718_maternal_effect1.39119605
51MP0004947_skin_inflammation1.37070076
52MP0005025_abnormal_response_to1.35826291
53MP0009697_abnormal_copulation1.35557434
54MP0000015_abnormal_ear_pigmentation1.34216821
55MP0003195_calcinosis1.33297003
56MP0002148_abnormal_hypersensitivity_rea1.30764220
57MP0000609_abnormal_liver_physiology1.30740793
58MP0008872_abnormal_physiological_respon1.29579413
59MP0001764_abnormal_homeostasis1.25839287
60MP0000689_abnormal_spleen_morphology1.24378358
61MP0005174_abnormal_tail_pigmentation1.23913711
62MP0004019_abnormal_vitamin_homeostasis1.21768346
63MP0000858_altered_metastatic_potential1.20685490
64MP0002118_abnormal_lipid_homeostasis1.20245494
65* MP0002429_abnormal_blood_cell1.19839532
66MP0005164_abnormal_response_to1.18415996
67MP0004036_abnormal_muscle_relaxation1.18339264
68MP0008775_abnormal_heart_ventricle1.18326639
69MP0008469_abnormal_protein_level1.18189726
70MP0002722_abnormal_immune_system1.15170098
71* MP0000716_abnormal_immune_system1.15034993
72MP0008874_decreased_physiological_sensi1.13519004
73MP0003866_abnormal_defecation1.12772569
74MP0005310_abnormal_salivary_gland1.12414839
75MP0005319_abnormal_enzyme/_coenzyme1.12344265
76MP0003879_abnormal_hair_cell1.11411060
77MP0001666_abnormal_nutrient_absorption1.08007450
78MP0003045_fibrosis1.06622933
79MP0005165_increased_susceptibility_to1.06018908
80MP0003303_peritoneal_inflammation1.04901857
81MP0003300_gastrointestinal_ulcer1.04295017
82MP0001533_abnormal_skeleton_physiology1.04036971
83MP0006082_CNS_inflammation1.01065601
84MP0009379_abnormal_foot_pigmentation1.00649170
85MP0001845_abnormal_inflammatory_respons0.99776452
86MP0009763_increased_sensitivity_to0.99313033
87MP0005584_abnormal_enzyme/coenzyme_acti0.98696951
88MP0001968_abnormal_touch/_nociception0.98647068
89MP0009765_abnormal_xenobiotic_induced0.98153947
90MP0004272_abnormal_basement_membrane0.97840661
91MP0003186_abnormal_redox_activity0.97819041
92MP0005000_abnormal_immune_tolerance0.97276420
93MP0002452_abnormal_antigen_presenting0.95767999
94MP0002998_abnormal_bone_remodeling0.95505197
95* MP0000249_abnormal_blood_vessel0.95222214
96MP0003656_abnormal_erythrocyte_physiolo0.94416052
97MP0002733_abnormal_thermal_nociception0.93880926
98MP0009333_abnormal_splenocyte_physiolog0.93853913
99* MP0009642_abnormal_blood_homeostasis0.93697940
100MP0003690_abnormal_glial_cell0.92787418
101MP0005395_other_phenotype0.92761019
102MP0009643_abnormal_urine_homeostasis0.88148495
103MP0002723_abnormal_immune_serum0.88139656
104MP0005671_abnormal_response_to0.86164231
105MP0005387_immune_system_phenotype0.85693934
106MP0001790_abnormal_immune_system0.85693934
107MP0000767_abnormal_smooth_muscle0.85080791
108MP0006054_spinal_hemorrhage0.84843261
109MP0003763_abnormal_thymus_physiology0.84198893
110MP0003011_delayed_dark_adaptation0.82911627
111MP0005381_digestive/alimentary_phenotyp0.82361453
112MP0003172_abnormal_lysosome_physiology0.82328304
113MP0004484_altered_response_of0.81726832
114MP0009278_abnormal_bone_marrow0.81117490
115MP0008260_abnormal_autophagy0.80936659
116MP0000598_abnormal_liver_morphology0.80580360
117MP0004147_increased_porphyrin_level0.80149513
118MP0004381_abnormal_hair_follicle0.79667502
119MP0005647_abnormal_sex_gland0.79387822
120MP0005451_abnormal_body_composition0.79073303
121MP0005646_abnormal_pituitary_gland0.76639125
122MP0005595_abnormal_vascular_smooth0.76584208
123MP0005376_homeostasis/metabolism_phenot0.76363765
124MP0000343_altered_response_to0.75696923
125MP0001800_abnormal_humoral_immune0.75210083
126MP0000703_abnormal_thymus_morphology0.74981082
127MP0002405_respiratory_system_inflammati0.74278612
128MP0001819_abnormal_immune_cell0.74201843
129* MP0010155_abnormal_intestine_physiology0.73586692
130MP0001765_abnormal_ion_homeostasis0.73314393
131MP0000685_abnormal_immune_system0.73071751
132MP0002420_abnormal_adaptive_immunity0.72237491
133MP0001881_abnormal_mammary_gland0.71766327
134MP0001970_abnormal_pain_threshold0.71282966
135MP0005166_decreased_susceptibility_to0.70034422
136MP0006276_abnormal_autonomic_nervous0.69519253
137MP0005266_abnormal_metabolism0.68151637
138MP0004215_abnormal_myocardial_fiber0.68039598
139MP0002971_abnormal_brown_adipose0.67674528
140MP0002876_abnormal_thyroid_physiology0.67515136
141MP0005670_abnormal_white_adipose0.66925207
142MP0003136_yellow_coat_color0.66391021
143MP0001545_abnormal_hematopoietic_system0.65394968
144MP0005397_hematopoietic_system_phenotyp0.65394968
145MP0001663_abnormal_digestive_system0.64042673
146MP0003868_abnormal_feces_composition0.64027534
147MP0005535_abnormal_body_temperature0.63468988

Predicted human phenotypes

RankGene SetZ-score
1Increased mean platelet volume (HP:0011877)9.42822441
2Petechiae (HP:0000967)8.90636943
3Recurrent gram-negative bacterial infections (HP:0005420)6.72505298
4Eczematoid dermatitis (HP:0000976)5.80863559
5Deep venous thrombosis (HP:0002625)5.43900599
6Joint hemorrhage (HP:0005261)5.15811493
7Abnormality of aromatic amino acid family metabolism (HP:0004338)4.97708059
8Prolonged partial thromboplastin time (HP:0003645)4.88007699
9Frequent falls (HP:0002359)4.58092376
10Intrahepatic cholestasis (HP:0001406)4.52661707
11Hypercholesterolemia (HP:0003124)4.44877003
12Abnormality of monocarboxylic acid metabolism (HP:0010996)4.42465890
13Recurrent bacterial skin infections (HP:0005406)4.24066055
14Recurrent abscess formation (HP:0002722)4.10536891
15Poikilocytosis (HP:0004447)4.03813615
16Xanthomatosis (HP:0000991)4.03372893
17Hypobetalipoproteinemia (HP:0003563)3.90572856
18Dyschromatopsia (HP:0007641)3.76577895
19Acanthocytosis (HP:0001927)3.68912574
20Complement deficiency (HP:0004431)3.50750834
21Hyperlipoproteinemia (HP:0010980)3.49555450
22Abnormality of the common coagulation pathway (HP:0010990)3.48549584
23Vacuolated lymphocytes (HP:0001922)3.40216699
24Bruising susceptibility (HP:0000978)3.35055763
25Stomatitis (HP:0010280)3.34670943
26Abnormality of macrophages (HP:0004311)3.12773321
27Abnormal pupillary function (HP:0007686)3.12382650
28Abnormality of glutamine family amino acid metabolism (HP:0010902)3.08716809
29Systemic lupus erythematosus (HP:0002725)3.04366996
30Reduced subcutaneous adipose tissue (HP:0003758)3.03220123
31Mediastinal lymphadenopathy (HP:0100721)3.00622860
32Abnormality of the heme biosynthetic pathway (HP:0010472)2.96649872
33Menorrhagia (HP:0000132)2.95176503
34Paralysis (HP:0003470)2.92990932
35Hypolipoproteinemia (HP:0010981)2.88052478
36Recurrent skin infections (HP:0001581)2.86313149
37Gingivitis (HP:0000230)2.82558433
38Growth hormone excess (HP:0000845)2.81789435
39Arterial thrombosis (HP:0004420)2.80630109
40Abnormality of pyrimidine metabolism (HP:0004353)2.80420148
41Spontaneous hematomas (HP:0007420)2.79690223
42Increased neuronal autofluorescent lipopigment (HP:0002074)2.77705121
43Gingival bleeding (HP:0000225)2.76911004
44Mucosal telangiectasiae (HP:0100579)2.74908504
45Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.74527155
46Epidermoid cyst (HP:0200040)2.70366404
47Glomerulonephritis (HP:0000099)2.69552814
48Encephalitis (HP:0002383)2.69355147
49Myocardial infarction (HP:0001658)2.68065946
50Purpura (HP:0000979)2.67293915
51Tinnitus (HP:0000360)2.66593288
52Abnormality of lateral ventricle (HP:0030047)2.65650433
53Increased density of long bones (HP:0006392)2.64365303
54Obstructive lung disease (HP:0006536)2.64356613
55Chronic obstructive pulmonary disease (HP:0006510)2.64356613
56Amyloidosis (HP:0011034)2.63869559
57Abnormality of complement system (HP:0005339)2.62554903
58Abnormality of the intrinsic pathway (HP:0010989)2.61162947
59Joint swelling (HP:0001386)2.60783943
60Increased cerebral lipofuscin (HP:0011813)2.54883458
61Hypoalphalipoproteinemia (HP:0003233)2.54268743
62Hepatosplenomegaly (HP:0001433)2.54216779
63Glucose intolerance (HP:0000833)2.53510666
64Optic neuritis (HP:0100653)2.52526724
65Retrobulbar optic neuritis (HP:0100654)2.52526724
66Fat malabsorption (HP:0002630)2.50594045
67Spontaneous abortion (HP:0005268)2.49402949
68Abnormality of the vasculature of the conjunctiva (HP:0008054)2.45130772
69Esophageal varix (HP:0002040)2.44758741
70Episodic fever (HP:0001954)2.42561584
71Xerostomia (HP:0000217)2.42017704
72Bone cyst (HP:0012062)2.40828830
73Pancreatitis (HP:0001733)2.40184055
74Elevated erythrocyte sedimentation rate (HP:0003565)2.39957238
75Thrombophlebitis (HP:0004418)2.34722841
76Increased IgM level (HP:0003496)2.34358960
77Abnormality of methionine metabolism (HP:0010901)2.32257475
78Dysdiadochokinesis (HP:0002075)2.31227539
79Abnormality of aspartate family amino acid metabolism (HP:0010899)2.31158080
80Hyperammonemia (HP:0001987)2.31131636
81Recurrent fungal infections (HP:0002841)2.29741203
82Abnormality of sulfur amino acid metabolism (HP:0004339)2.29538654
83Abnormal glucose tolerance (HP:0001952)2.29169108
84Hypertriglyceridemia (HP:0002155)2.28569613
85Hepatocellular carcinoma (HP:0001402)2.27020100
86Orchitis (HP:0100796)2.26625508
87Urticaria (HP:0001025)2.25989286
88Cellulitis (HP:0100658)2.25939624
89Epistaxis (HP:0000421)2.25432086
90Pulmonary embolism (HP:0002204)2.25163047
91Decreased central vision (HP:0007663)2.20946678
92Vertigo (HP:0002321)2.18819015
93Beaking of vertebral bodies (HP:0004568)2.18540224
94Myositis (HP:0100614)2.17459503
95Hemorrhage of the eye (HP:0011885)2.16197431
96Conjunctival telangiectasia (HP:0000524)2.15417119
97Hyperbilirubinemia (HP:0002904)2.13776982
98Hypoglycemic coma (HP:0001325)2.10946631
99Delayed CNS myelination (HP:0002188)2.10927941
100Pulmonary infiltrates (HP:0002113)2.10259512
101Abnormality of saccadic eye movements (HP:0000570)2.10092745
102Basal ganglia calcification (HP:0002135)2.08756295
103Abnormal auditory evoked potentials (HP:0006958)2.08578058
104Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.07870208
105Hyperglycinuria (HP:0003108)2.05679100
106Gaze-evoked nystagmus (HP:0000640)2.05503351
107Ventricular fibrillation (HP:0001663)2.05204467
108Abnormality of transition element cation homeostasis (HP:0011030)2.04936459
109Impaired platelet aggregation (HP:0003540)2.04084488
110Abnormal platelet function (HP:0011869)2.04084488
111Autoimmune thrombocytopenia (HP:0001973)2.03854218
112Polycythemia (HP:0001901)2.02733257
113Microcytic anemia (HP:0001935)2.02004102
114Lower limb hyperreflexia (HP:0002395)2.01462324
115Increased serum ferritin (HP:0003281)2.01277062
116Abnormality of the lumbar spine (HP:0100712)2.00261363
117Abnormality of Sharpey fibers (HP:0100685)1.99477345
118Chest pain (HP:0100749)1.98288150
119Osteomyelitis (HP:0002754)1.96135163
120Conjugated hyperbilirubinemia (HP:0002908)1.95242954
121Abnormal platelet volume (HP:0011876)1.95106459
122Keratoconjunctivitis (HP:0001096)1.94616505
123Male infertility (HP:0003251)1.94556237
124Abnormality of nucleobase metabolism (HP:0010932)1.93610734
125Nephritis (HP:0000123)1.93183842
126Hyperglycinemia (HP:0002154)1.91461753
127Ketosis (HP:0001946)1.90376901
128Abnormality of iron homeostasis (HP:0011031)1.90129168
129Prolonged bleeding time (HP:0003010)1.90070654
130Cerebral hemorrhage (HP:0001342)1.89799803
131Cholelithiasis (HP:0001081)1.89520182
132Steatorrhea (HP:0002570)1.88005547
133Thyroid-stimulating hormone excess (HP:0002925)1.87679281
134Generalized aminoaciduria (HP:0002909)1.87570677
135Abnormality of the prostate (HP:0008775)1.87555912
136Keratoconjunctivitis sicca (HP:0001097)1.85661523
137Upper limb muscle weakness (HP:0003484)1.83326710
138Arthropathy (HP:0003040)1.83064688
139Papillary thyroid carcinoma (HP:0002895)1.81357583
140Congenital sensorineural hearing impairment (HP:0008527)1.80048208
141Nausea (HP:0002018)1.78310528
142Dysostosis multiplex (HP:0000943)1.73312621
143Muscle fibrillation (HP:0010546)1.70336538
144Autoimmune hemolytic anemia (HP:0001890)1.69952934
145Leukocytosis (HP:0001974)1.68226920
146Vasculitis (HP:0002633)1.66742491
147Dysautonomia (HP:0002459)1.64313312
148Gangrene (HP:0100758)1.64240133
149Meningitis (HP:0001287)1.62910705
150Tongue fasciculations (HP:0001308)1.60709222
151Testicular neoplasm (HP:0010788)1.60421061
152Cerebral ischemia (HP:0002637)1.59074311
1533-Methylglutaconic aciduria (HP:0003535)1.58843461
154Thrombocytosis (HP:0001894)1.57596085
155Anorexia (HP:0002039)1.56553300
156Abnormal ciliary motility (HP:0012262)1.55234629
157Glomerulopathy (HP:0100820)1.52411800
158Eosinophilia (HP:0001880)1.50159706
159Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.50120042
160Hypophosphatemic rickets (HP:0004912)1.48933772
161Bilateral sensorineural hearing impairment (HP:0008619)1.47967117
162Diplopia (HP:0000651)1.47367246
163Abnormality of binocular vision (HP:0011514)1.47367246
164Arthralgia (HP:0002829)1.47286273
165Biliary tract neoplasm (HP:0100574)1.46957923
166Granulocytopenia (HP:0001913)1.46592238

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE14.45138597
2BLK3.91722431
3BMPR1B3.77703934
4KDR3.58236970
5BMX3.48649626
6RIPK43.13815471
7MAP3K143.10845520
8ERN12.99791391
9TGFBR12.92965488
10CSF1R2.38102405
11ABL22.31236119
12TGFBR22.30428685
13IKBKE2.28928710
14GRK62.09751613
15TBK12.08543240
16CAMKK12.05878629
17FGR2.05193412
18PBK1.99982610
19EIF2AK11.99197106
20GRK51.88220324
21FGFR41.85944427
22EPHB11.84423685
23TYK21.84127047
24FRK1.83128779
25INSRR1.71693732
26BCKDK1.67398217
27NEK91.59775002
28MST1R1.57415983
29MST41.54355456
30ILK1.51608432
31GRK11.50333776
32MAP3K131.47536554
33MAPKAPK31.45996493
34IRAK11.41467114
35ADRBK21.37933227
36IKBKB1.37639888
37MAP2K31.34792747
38TNK21.32311448
39YES11.31715062
40STK31.25287971
41KIT1.22141743
42LATS11.17499261
43TEC1.17187693
44TXK1.16455939
45ACVR1B1.09919962
46IRAK41.09377458
47JAK21.07374673
48PLK21.06223533
49MAP3K121.06179160
50JAK11.05712927
51MAPK121.05673834
52SIK11.05290336
53STK241.03322397
54MAP4K11.01010215
55PTK61.00386728
56PAK10.97089988
57CSK0.96964693
58EPHA30.96416863
59ABL10.95112912
60LMTK20.87804527
61ADRBK10.87593303
62PDK10.84876271
63MAP3K50.84480751
64MAPK40.81867545
65LYN0.81013211
66SYK0.79174651
67GRK70.79088135
68ZAP700.76994760
69DAPK30.75600710
70SIK30.72722219
71RET0.72691959
72MYLK0.72157333
73MAP2K60.70616260
74MKNK20.69974465
75TAOK20.69355346
76PKN20.67179561
77ERBB40.66450422
78PTK2B0.66109698
79TNIK0.65487875
80BTK0.64540267
81PIK3CA0.64122084
82PRKG20.63725882
83PDPK10.63704665
84RIPK10.63320802
85EPHB20.63165381
86CDK190.62961307
87LCK0.62282921
88PRKD10.61577389
89FGFR30.61392050
90ERBB30.60234944
91PIM20.59116395
92MAP3K30.59067223
93MARK30.57173112
94DAPK20.55971268
95TAOK10.55903636
96EGFR0.55620682
97ITK0.54422025
98NUAK10.53916009
99BMPR20.53670821
100WNK30.53234281
101HCK0.52930407
102FYN0.52874411
103TLK10.51959542
104TRPM70.51912647
105ERBB20.50901122
106PNCK0.50872583
107PRKCD0.49682718
108CSNK1D0.48998458
109PIK3CG0.47859573
110FES0.47621635
111TESK20.46688953
112TAOK30.46332014
113PASK0.46070602
114MAP3K110.45896204
115GSK3A0.45461386
116MAP2K40.44630940
117PRKG10.44503514
118FER0.44163911
119EIF2AK20.44058732
120PRKCQ0.43868600
121INSR0.42947100
122STK40.42664722
123PDGFRB0.41210128
124IGF1R0.40186330
125MKNK10.40084758
126IRAK20.39789286
127PRKACG0.39667451
128MAP3K10.39642296
129PRKAA20.38483519
130MATK0.38438744
131MAP2K10.38033857
132CAMKK20.37270521
133SRC0.36977689
134PIM10.36854523
135MAPK110.36746024
136AKT30.36123057
137PKN10.35501623
138MAPK70.33323483
139CSNK2A20.33109037
140MAP3K60.32311474
141CHUK0.32251577
142CDK80.32206285
143JAK30.32158429
144MAPK130.31598384
145PRKCB0.31180972
146TRIM280.28704917
147DAPK10.28380518
148MINK10.25416314
149PRKCA0.24637841
150PAK30.24104918
151SGK20.23363535

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.52818868
2Complement and coagulation cascades_Homo sapiens_hsa046103.79033450
3Staphylococcus aureus infection_Homo sapiens_hsa051503.29969826
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.07276172
5Nitrogen metabolism_Homo sapiens_hsa009103.02858063
6Arginine biosynthesis_Homo sapiens_hsa002202.98140762
7Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.88294403
8Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.81704124
9Non-homologous end-joining_Homo sapiens_hsa034502.81342902
10SNARE interactions in vesicular transport_Homo sapiens_hsa041302.81316290
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.67829502
12Pentose and glucuronate interconversions_Homo sapiens_hsa000402.49272273
13Arachidonic acid metabolism_Homo sapiens_hsa005902.32298092
14Tryptophan metabolism_Homo sapiens_hsa003802.07760116
15Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.05985440
16Chemokine signaling pathway_Homo sapiens_hsa040621.91993612
17Drug metabolism - other enzymes_Homo sapiens_hsa009831.89188040
18Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.88706061
19Fatty acid degradation_Homo sapiens_hsa000711.86949536
20PPAR signaling pathway_Homo sapiens_hsa033201.82694205
21Peroxisome_Homo sapiens_hsa041461.80946196
22Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.80422216
23Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.77607910
24Chemical carcinogenesis_Homo sapiens_hsa052041.65939110
25Histidine metabolism_Homo sapiens_hsa003401.65809051
26Serotonergic synapse_Homo sapiens_hsa047261.62765952
27Steroid hormone biosynthesis_Homo sapiens_hsa001401.61592647
28Caffeine metabolism_Homo sapiens_hsa002321.59679689
29ECM-receptor interaction_Homo sapiens_hsa045121.57753538
30alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.54833192
31Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.50836852
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.50706856
33Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.46040187
34Vascular smooth muscle contraction_Homo sapiens_hsa042701.46006516
35Retinol metabolism_Homo sapiens_hsa008301.40728100
36Starch and sucrose metabolism_Homo sapiens_hsa005001.35560020
37Leishmaniasis_Homo sapiens_hsa051401.33111527
38Sulfur metabolism_Homo sapiens_hsa009201.30198945
39Phenylalanine metabolism_Homo sapiens_hsa003601.29839497
40Gap junction_Homo sapiens_hsa045401.29195515
41Systemic lupus erythematosus_Homo sapiens_hsa053221.28425026
42Linoleic acid metabolism_Homo sapiens_hsa005911.28342893
43beta-Alanine metabolism_Homo sapiens_hsa004101.26666529
44Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.25578990
45Collecting duct acid secretion_Homo sapiens_hsa049661.24063532
46Bile secretion_Homo sapiens_hsa049761.21436404
47Asthma_Homo sapiens_hsa053101.21244070
48Fatty acid metabolism_Homo sapiens_hsa012121.17352743
49T cell receptor signaling pathway_Homo sapiens_hsa046601.16865070
50Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.15802953
51Shigellosis_Homo sapiens_hsa051311.13447325
52Allograft rejection_Homo sapiens_hsa053301.12978251
53Butanoate metabolism_Homo sapiens_hsa006501.12726158
54Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.10507346
55Endocytosis_Homo sapiens_hsa041441.09121948
56Regulation of actin cytoskeleton_Homo sapiens_hsa048101.08785934
57Propanoate metabolism_Homo sapiens_hsa006401.07028866
58Primary immunodeficiency_Homo sapiens_hsa053401.06564189
59Osteoclast differentiation_Homo sapiens_hsa043801.04071842
60Folate biosynthesis_Homo sapiens_hsa007901.03978189
61Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.00200007
62Pancreatic secretion_Homo sapiens_hsa049720.99777809
63Autoimmune thyroid disease_Homo sapiens_hsa053200.98744692
64Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.96892268
65Tyrosine metabolism_Homo sapiens_hsa003500.95572188
66Phospholipase D signaling pathway_Homo sapiens_hsa040720.94771842
67Alcoholism_Homo sapiens_hsa050340.94039530
68ABC transporters_Homo sapiens_hsa020100.93008829
69Homologous recombination_Homo sapiens_hsa034400.91289957
70Fatty acid elongation_Homo sapiens_hsa000620.90552716
71Malaria_Homo sapiens_hsa051440.90286358
72Selenocompound metabolism_Homo sapiens_hsa004500.89039087
73Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.86543203
74Toll-like receptor signaling pathway_Homo sapiens_hsa046200.86472770
75Olfactory transduction_Homo sapiens_hsa047400.84692518
76Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.82168842
77Phagosome_Homo sapiens_hsa041450.78779195
78Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.76700134
79Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.75385080
80Pertussis_Homo sapiens_hsa051330.75314818
81Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.74992198
82Morphine addiction_Homo sapiens_hsa050320.71759104
83Choline metabolism in cancer_Homo sapiens_hsa052310.71011263
84Long-term depression_Homo sapiens_hsa047300.70994113
85Glycerophospholipid metabolism_Homo sapiens_hsa005640.70176938
86Jak-STAT signaling pathway_Homo sapiens_hsa046300.70135715
87Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.66161546
88Fat digestion and absorption_Homo sapiens_hsa049750.65980603
89Vitamin digestion and absorption_Homo sapiens_hsa049770.65316796
90Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.64253082
91Cysteine and methionine metabolism_Homo sapiens_hsa002700.63847350
92RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.63825285
93Calcium signaling pathway_Homo sapiens_hsa040200.63748835
94Steroid biosynthesis_Homo sapiens_hsa001000.62538476
95TNF signaling pathway_Homo sapiens_hsa046680.62237800
96Non-small cell lung cancer_Homo sapiens_hsa052230.61457650
97Pancreatic cancer_Homo sapiens_hsa052120.61316659
98Dorso-ventral axis formation_Homo sapiens_hsa043200.60850577
99Insulin resistance_Homo sapiens_hsa049310.59814366
1002-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.59362754
101Other glycan degradation_Homo sapiens_hsa005110.58455747
102Focal adhesion_Homo sapiens_hsa045100.58138016
103Type I diabetes mellitus_Homo sapiens_hsa049400.57780394
104Maturity onset diabetes of the young_Homo sapiens_hsa049500.57154725
105Rap1 signaling pathway_Homo sapiens_hsa040150.56937867
106Leukocyte transendothelial migration_Homo sapiens_hsa046700.56765065
107Lysosome_Homo sapiens_hsa041420.56636957
108Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.56340349
109Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.56244202
110NF-kappa B signaling pathway_Homo sapiens_hsa040640.56103167
111Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.55454424
112Phosphatidylinositol signaling system_Homo sapiens_hsa040700.55252959
113Legionellosis_Homo sapiens_hsa051340.54040656
114Hematopoietic cell lineage_Homo sapiens_hsa046400.53811852
115Rheumatoid arthritis_Homo sapiens_hsa053230.52577313
116Glutathione metabolism_Homo sapiens_hsa004800.52283465
117Ras signaling pathway_Homo sapiens_hsa040140.51547842
118Measles_Homo sapiens_hsa051620.51457317
119Cholinergic synapse_Homo sapiens_hsa047250.51113843
120Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.50161966
121Circadian entrainment_Homo sapiens_hsa047130.49955744
122Tuberculosis_Homo sapiens_hsa051520.49267452
123Arginine and proline metabolism_Homo sapiens_hsa003300.47886251
124Carbon metabolism_Homo sapiens_hsa012000.47510776
125Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.47283569
126NOD-like receptor signaling pathway_Homo sapiens_hsa046210.46262023
127Graft-versus-host disease_Homo sapiens_hsa053320.45894085
128Glycerolipid metabolism_Homo sapiens_hsa005610.45012374
129Apoptosis_Homo sapiens_hsa042100.45009471
130B cell receptor signaling pathway_Homo sapiens_hsa046620.44656222
131Platelet activation_Homo sapiens_hsa046110.43978504
132Glycosaminoglycan degradation_Homo sapiens_hsa005310.43170520
133Pentose phosphate pathway_Homo sapiens_hsa000300.42442439
134Viral carcinogenesis_Homo sapiens_hsa052030.41923862
135Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.41440023
136Biosynthesis of amino acids_Homo sapiens_hsa012300.40651456
137Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.40508469
138Adipocytokine signaling pathway_Homo sapiens_hsa049200.40207873
139Transcriptional misregulation in cancer_Homo sapiens_hsa052020.39483691
140Prion diseases_Homo sapiens_hsa050200.38927847
141Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.37147774
142Renin-angiotensin system_Homo sapiens_hsa046140.36334473
143VEGF signaling pathway_Homo sapiens_hsa043700.36206671
144Endometrial cancer_Homo sapiens_hsa052130.35913498
145Oxytocin signaling pathway_Homo sapiens_hsa049210.35637833
146African trypanosomiasis_Homo sapiens_hsa051430.34915118
147Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.34415683
148Amoebiasis_Homo sapiens_hsa051460.34087788
149Lysine degradation_Homo sapiens_hsa003100.31246265
150Type II diabetes mellitus_Homo sapiens_hsa049300.31149711
151Salmonella infection_Homo sapiens_hsa051320.29451593
152Viral myocarditis_Homo sapiens_hsa054160.26758344
153Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.26580528
154Influenza A_Homo sapiens_hsa051640.25118247
155Toxoplasmosis_Homo sapiens_hsa051450.24695966
156Intestinal immune network for IgA production_Homo sapiens_hsa046720.24589990
157Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.22451499
158Acute myeloid leukemia_Homo sapiens_hsa052210.22406768

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