CLEC2D

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the natural killer cell receptor C-type lectin family. The encoded protein inhibits osteoclast formation and contains a transmembrane domain near the N-terminus as well as the C-type lectin-like extracellular domain. Several alternatively spliced transcript variants have been identified for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.58026504
2negative T cell selection (GO:0043383)6.28980025
3positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)6.14265050
4negative thymic T cell selection (GO:0045060)5.87519820
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.78361916
6L-phenylalanine catabolic process (GO:0006559)5.78361916
7cellular response to interleukin-15 (GO:0071350)5.71867937
8regulation of B cell receptor signaling pathway (GO:0050855)5.67904350
9negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.67859260
10negative regulation of cell killing (GO:0031342)5.67859260
11antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.66357395
12L-phenylalanine metabolic process (GO:0006558)5.54129631
13erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.54129631
14response to interleukin-15 (GO:0070672)5.51245810
15cytidine deamination (GO:0009972)5.38437992
16cytidine metabolic process (GO:0046087)5.38437992
17cytidine catabolic process (GO:0006216)5.38437992
18aromatic amino acid family catabolic process (GO:0009074)5.30445018
19positive T cell selection (GO:0043368)5.19888350
20regulation of gamma-delta T cell differentiation (GO:0045586)5.10463253
21triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.03133069
22positive thymic T cell selection (GO:0045059)4.99250743
23pyrimidine ribonucleoside catabolic process (GO:0046133)4.99050922
24positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.95699813
25tryptophan catabolic process (GO:0006569)4.93875642
26indole-containing compound catabolic process (GO:0042436)4.93875642
27indolalkylamine catabolic process (GO:0046218)4.93875642
28regulation of gamma-delta T cell activation (GO:0046643)4.89313654
29alpha-linolenic acid metabolic process (GO:0036109)4.88686780
30complement activation, alternative pathway (GO:0006957)4.85971654
31urea cycle (GO:0000050)4.82671560
32urea metabolic process (GO:0019627)4.82671560
33kynurenine metabolic process (GO:0070189)4.82184582
34T cell migration (GO:0072678)4.78166636
35bile acid biosynthetic process (GO:0006699)4.73045258
36thymic T cell selection (GO:0045061)4.72887341
37activated T cell proliferation (GO:0050798)4.71343928
38DNA deamination (GO:0045006)4.68694183
39tryptophan metabolic process (GO:0006568)4.66499443
40regulation of regulatory T cell differentiation (GO:0045589)4.65243379
41regulation of protein activation cascade (GO:2000257)4.58752372
42T cell selection (GO:0045058)4.56593371
43fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.55003627
44negative regulation of fibrinolysis (GO:0051918)4.50026664
45regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.46857511
46peptidyl-glutamic acid carboxylation (GO:0017187)4.46790999
47protein carboxylation (GO:0018214)4.46790999
48sulfur amino acid catabolic process (GO:0000098)4.46735840
49regulation of alpha-beta T cell proliferation (GO:0046640)4.45825718
50nitrogen cycle metabolic process (GO:0071941)4.39811836
51regulation of complement activation (GO:0030449)4.36019421
52cysteine metabolic process (GO:0006534)4.32955536
53glyoxylate metabolic process (GO:0046487)4.31390368
54high-density lipoprotein particle remodeling (GO:0034375)4.30814918
55regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.29930138
56regulation of natural killer cell mediated immunity (GO:0002715)4.29930138
57regulation of triglyceride catabolic process (GO:0010896)4.28017739
58regulation of isotype switching to IgG isotypes (GO:0048302)4.26250064
59regulation of fibrinolysis (GO:0051917)4.26082874
60regulation of B cell differentiation (GO:0045577)4.24014324
61regulation of T cell tolerance induction (GO:0002664)4.22459295
62homocysteine metabolic process (GO:0050667)4.22166121
63positive regulation of alpha-beta T cell proliferation (GO:0046641)4.21027538
64negative regulation of T cell mediated immunity (GO:0002710)4.17867998
65positive regulation of natural killer cell mediated immunity (GO:0002717)4.14563173
66positive regulation of B cell differentiation (GO:0045579)4.13534640
67regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.10279531
68interferon-gamma production (GO:0032609)4.08688436
69bile acid metabolic process (GO:0008206)4.06551650
70regulation of interleukin-2 biosynthetic process (GO:0045076)4.05865344
71plasma lipoprotein particle clearance (GO:0034381)4.04408878
72positive regulation of leukocyte mediated cytotoxicity (GO:0001912)4.03562051
73regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.98197538
74phospholipid efflux (GO:0033700)3.98145535
75positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.92090792
76B cell receptor signaling pathway (GO:0050853)3.91013663
77positive regulation of T cell mediated cytotoxicity (GO:0001916)3.90177916
78serine family amino acid catabolic process (GO:0009071)3.88982632
79regulation of leukocyte mediated cytotoxicity (GO:0001910)3.88569483
80regulation of T cell mediated cytotoxicity (GO:0001914)3.87683233
81negative regulation of sterol transport (GO:0032372)3.85423530
82negative regulation of cholesterol transport (GO:0032375)3.85423530
83positive regulation of defense response to virus by host (GO:0002230)3.84924909
84reverse cholesterol transport (GO:0043691)3.83324012
85cellular response to type I interferon (GO:0071357)3.82226131
86type I interferon signaling pathway (GO:0060337)3.82226131
87lysine metabolic process (GO:0006553)3.82035952
88lysine catabolic process (GO:0006554)3.82035952
89phospholipid homeostasis (GO:0055091)3.80961890
90response to type I interferon (GO:0034340)3.79818002
91positive regulation of cell killing (GO:0031343)3.78892527
92positive regulation of granulocyte differentiation (GO:0030854)3.78470912
93valine metabolic process (GO:0006573)3.78208130
94aromatic amino acid family metabolic process (GO:0009072)3.76798809
95positive regulation of tolerance induction (GO:0002645)3.76763064
96plasma lipoprotein particle remodeling (GO:0034369)3.76237223
97protein-lipid complex remodeling (GO:0034368)3.76237223
98macromolecular complex remodeling (GO:0034367)3.76237223
99triglyceride homeostasis (GO:0070328)3.74532050
100acylglycerol homeostasis (GO:0055090)3.74532050
101positive regulation of humoral immune response (GO:0002922)3.72047066
102ethanol oxidation (GO:0006069)3.67675232
103regulation of cholesterol esterification (GO:0010872)3.66471354
104regulation of cell killing (GO:0031341)3.66070118
105amino-acid betaine metabolic process (GO:0006577)3.65699526
106tyrosine metabolic process (GO:0006570)3.64830119
107T cell receptor signaling pathway (GO:0050852)3.63832802
108antigen receptor-mediated signaling pathway (GO:0050851)3.63385043
109antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.61686074
110antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.61686074
111negative regulation of lymphocyte mediated immunity (GO:0002707)3.61411096
112regulation of tolerance induction (GO:0002643)3.60821468
113CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.58282713
114positive regulation of fatty acid beta-oxidation (GO:0032000)3.55293302
115alpha-amino acid catabolic process (GO:1901606)3.55067255
116positive regulation of lipid catabolic process (GO:0050996)3.55047028
117bile acid and bile salt transport (GO:0015721)3.51653961
118tolerance induction (GO:0002507)3.51415770
119cholesterol efflux (GO:0033344)3.49973828
120plasma lipoprotein particle assembly (GO:0034377)3.49298037
121complement activation, classical pathway (GO:0006958)3.49150517
122negative regulation of viral genome replication (GO:0045071)3.48880072
123complement activation (GO:0006956)3.46917381
124indolalkylamine metabolic process (GO:0006586)3.43707986
125T cell costimulation (GO:0031295)3.39991541
126acetyl-CoA metabolic process (GO:0006084)3.39434181
127regulation of cholesterol homeostasis (GO:2000188)3.38948826
128lymphocyte costimulation (GO:0031294)3.38600045
129coenzyme catabolic process (GO:0009109)3.35258246
130regulation of T cell receptor signaling pathway (GO:0050856)3.34988494
131cellular response to interferon-beta (GO:0035458)3.33758042
132dicarboxylic acid biosynthetic process (GO:0043650)3.32003957
133NIK/NF-kappaB signaling (GO:0038061)3.31840188
134positive regulation of isotype switching (GO:0045830)3.31524496
135regulation of chronic inflammatory response (GO:0002676)3.30586728
136cellular glucuronidation (GO:0052695)3.29676074
1372-oxoglutarate metabolic process (GO:0006103)3.29572521
138antigen processing and presentation of endogenous antigen (GO:0019883)3.29560505
139leukocyte aggregation (GO:0070486)3.29159935
140fibrinolysis (GO:0042730)3.28902909
141low-density lipoprotein particle clearance (GO:0034383)3.28500428
142benzene-containing compound metabolic process (GO:0042537)3.28477360
143protein-lipid complex assembly (GO:0065005)3.28368039
144protein activation cascade (GO:0072376)3.28259861
145epoxygenase P450 pathway (GO:0019373)3.27960690
146drug catabolic process (GO:0042737)3.27588756
147response to interferon-beta (GO:0035456)3.26919751
148cellular amino acid catabolic process (GO:0009063)3.26842667
149cellular modified amino acid catabolic process (GO:0042219)3.24272964
150cellular biogenic amine catabolic process (GO:0042402)3.22973529
151amine catabolic process (GO:0009310)3.22973529
152negative regulation of interleukin-12 production (GO:0032695)3.22919614
153imidazole-containing compound metabolic process (GO:0052803)3.21865077
154regulation of interleukin-12 biosynthetic process (GO:0045075)3.20704499
155cholesterol homeostasis (GO:0042632)3.19697989
156positive regulation of interleukin-2 production (GO:0032743)3.19112930
157positive regulation of immunoglobulin mediated immune response (GO:0002891)3.18065630
158positive regulation of B cell mediated immunity (GO:0002714)3.18065630
159positive regulation of DNA recombination (GO:0045911)3.16327289
160positive regulation of lymphocyte mediated immunity (GO:0002708)3.15235923
161sterol homeostasis (GO:0055092)3.15169574
162mast cell activation (GO:0045576)3.14976889
163antigen processing and presentation via MHC class Ib (GO:0002475)3.14715876
164glutamate metabolic process (GO:0006536)3.13994097
165positive regulation of lipoprotein lipase activity (GO:0051006)3.13858434
166positive regulation of triglyceride lipase activity (GO:0061365)3.13858434
167cytolysis (GO:0019835)3.13564177
168negative regulation of lipase activity (GO:0060192)3.13034985
169negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.12983998
170glycine metabolic process (GO:0006544)3.12284415
171interferon-gamma-mediated signaling pathway (GO:0060333)3.11911114
172negative regulation of leukocyte mediated immunity (GO:0002704)3.11882393
173positive regulation of calcium-mediated signaling (GO:0050850)3.11459904
174regulation of alpha-beta T cell activation (GO:0046634)3.11383237
175fatty acid oxidation (GO:0019395)3.10539129
176defense response to protozoan (GO:0042832)3.10353278
177negative regulation of B cell proliferation (GO:0030889)3.09963563
178fatty acid beta-oxidation (GO:0006635)3.09586020
179regulation of bile acid biosynthetic process (GO:0070857)3.08826966
180negative regulation of adaptive immune response (GO:0002820)3.08696459
181acute-phase response (GO:0006953)3.08198746
182lipoprotein metabolic process (GO:0042157)3.05528636
183fatty acid transmembrane transport (GO:1902001)3.04946535
184plasma lipoprotein particle organization (GO:0071827)3.03964698
185regulation of humoral immune response (GO:0002920)3.03960112
186lipid oxidation (GO:0034440)3.03950989
187T cell homeostasis (GO:0043029)3.02781996
188regulation of fatty acid beta-oxidation (GO:0031998)3.02578916
189very-low-density lipoprotein particle assembly (GO:0034379)3.00685243
190cellular defense response (GO:0006968)3.00544195
191regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.99373159
192lymphocyte migration (GO:0072676)2.99185245
193positive regulation of T cell mediated immunity (GO:0002711)2.99137405
194negative regulation of T cell apoptotic process (GO:0070233)2.98552121
195immunoglobulin mediated immune response (GO:0016064)2.96764222
196negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.94192843
197regulation of T cell mediated immunity (GO:0002709)2.90843858

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.52548860
2RXR_22158963_ChIP-Seq_LIVER_Mouse6.17318667
3PPARA_22158963_ChIP-Seq_LIVER_Mouse5.47506828
4* EGR1_23403033_ChIP-Seq_LIVER_Mouse5.12697913
5* LXR_22158963_ChIP-Seq_LIVER_Mouse5.02449576
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.75192416
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.84451883
8IRF8_22096565_ChIP-ChIP_GC-B_Human3.79526412
9* CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.45819232
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.12729035
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.75391341
12GATA1_22025678_ChIP-Seq_K562_Human2.70959086
13CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.61864048
14FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.46261110
15NOTCH1_21737748_ChIP-Seq_TLL_Human2.39939280
16STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.34974142
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.20830305
18TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.20705124
19GATA3_26560356_Chip-Seq_TH2_Human2.19693794
20CLOCK_20551151_ChIP-Seq_293T_Human2.19655046
21FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.12706148
22SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.04497831
23E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.01302491
24NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.00113522
25STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.95524533
26SPI1_23547873_ChIP-Seq_NB4_Human1.95176435
27STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.92154246
28IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.84497033
29SMAD_19615063_ChIP-ChIP_OVARY_Human1.81270236
30CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.77650537
31IRF8_21731497_ChIP-ChIP_J774_Mouse1.76500733
32IRF8_27001747_Chip-Seq_BMDM_Mouse1.76077407
33* MAF_26560356_Chip-Seq_TH2_Human1.75653770
34RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.72950316
35SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.71041109
36TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.65722141
37NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.64590710
38CIITA_25753668_ChIP-Seq_RAJI_Human1.63601177
39* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.61884868
40SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.55582301
41FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.51938373
42RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.49813041
43HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.49629537
44FLI1_27457419_Chip-Seq_LIVER_Mouse1.49256364
45VDR_23849224_ChIP-Seq_CD4+_Human1.47914432
46FOXA2_19822575_ChIP-Seq_HepG2_Human1.46696173
47RUNX_20019798_ChIP-Seq_JUKART_Human1.42011542
48NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.39089676
49LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.38878291
50STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.33909196
51FOXO3_23340844_ChIP-Seq_DLD1_Human1.31021241
52THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.30612235
53MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.30344838
54BRD4_27068464_Chip-Seq_AML-cells_Mouse1.28015111
55CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.26117762
56FOXP3_21729870_ChIP-Seq_TREG_Human1.25375372
57MYB_21317192_ChIP-Seq_ERMYB_Mouse1.24876458
58PCGF2_27294783_Chip-Seq_NPCs_Mouse1.23687061
59RARG_19884340_ChIP-ChIP_MEFs_Mouse1.20165296
60MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.19598504
61RUNX1_22412390_ChIP-Seq_EML_Mouse1.15709779
62PCGF2_27294783_Chip-Seq_ESCs_Mouse1.14935110
63* MAF_26560356_Chip-Seq_TH1_Human1.14008213
64SPI1_23127762_ChIP-Seq_K562_Human1.13705498
65* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.13677602
66TP63_17297297_ChIP-ChIP_HaCaT_Human1.12087630
67SOX2_27498859_Chip-Seq_STOMACH_Mouse1.11655976
68VDR_24763502_ChIP-Seq_THP-1_Human1.10028347
69TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.08754573
70HNF4A_19822575_ChIP-Seq_HepG2_Human1.07083332
71LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.06319218
72ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.06043377
73GATA2_21666600_ChIP-Seq_HMVEC_Human1.05592216
74* GATA3_26560356_Chip-Seq_TH1_Human1.03822002
75VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.02824846
76PPAR_26484153_Chip-Seq_NCI-H1993_Human1.02256036
77E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.01442980
78ESR2_21235772_ChIP-Seq_MCF-7_Human1.01262813
79VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.00829730
80GATA4_25053715_ChIP-Seq_YYC3_Human0.99583877
81STAT4_19710469_ChIP-ChIP_TH1__Mouse0.99196312
82* MYB_26560356_Chip-Seq_TH1_Human0.99029220
83* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.98778824
84* SMRT_27268052_Chip-Seq_Bcells_Human0.98348797
85TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95620048
86MYB_26560356_Chip-Seq_TH2_Human0.94578904
87GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.94351257
88ESR1_21235772_ChIP-Seq_MCF-7_Human0.92617517
89BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.91870104
90VDR_22108803_ChIP-Seq_LS180_Human0.91259354
91HOXB4_20404135_ChIP-ChIP_EML_Mouse0.90998154
92* TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.90604179
93NFE2_27457419_Chip-Seq_LIVER_Mouse0.89424264
94EST1_17652178_ChIP-ChIP_JURKAT_Human0.89307373
95* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89131457
96SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.89047321
97KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.88050613
98ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.87523707
99TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.87394986
100SUZ12_27294783_Chip-Seq_NPCs_Mouse0.85243155
101TCF7_22412390_ChIP-Seq_EML_Mouse0.85242317
102GABP_17652178_ChIP-ChIP_JURKAT_Human0.85132968
103CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.85029329
104ZNF263_19887448_ChIP-Seq_K562_Human0.84296195
105FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84199733
106KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.84126085
107NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.83446782
108* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.83245247
109UTX_26944678_Chip-Seq_JUKART_Human0.83150762
110BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.82716051
111CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.81903584
112GATA2_19941826_ChIP-Seq_K562_Human0.81713243
113GATA2_22383799_ChIP-Seq_G1ME_Mouse0.81030676
114SCL_19346495_ChIP-Seq_HPC-7_Human0.80972398
115GATA1_19941826_ChIP-Seq_K562_Human0.80378430
116PU_27001747_Chip-Seq_BMDM_Mouse0.80149299
117RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.79954584
118GATA6_25053715_ChIP-Seq_YYC3_Human0.79764852
119RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.79553967
120* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.79394972
121TRIM28_21343339_ChIP-Seq_HEK293_Human0.78251370
122AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.78215060
123MYC_22102868_ChIP-Seq_BL_Human0.77927898
124CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.77702682
125VDR_24787735_ChIP-Seq_THP-1_Human0.77295586
126RXRA_24833708_ChIP-Seq_LIVER_Mouse0.77084895
127* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.75582697
128GATA3_27048872_Chip-Seq_THYMUS_Human0.75565468
129* ELK3_25401928_ChIP-Seq_HUVEC_Human0.75295654
130EZH2_27294783_Chip-Seq_NPCs_Mouse0.74365715
131EGR1_19032775_ChIP-ChIP_M12_Human0.73835180
132BP1_19119308_ChIP-ChIP_Hs578T_Human0.73387621
133SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.73281242
134CDX2_20551321_ChIP-Seq_CACO-2_Human0.73044042
135PRDM14_20953172_ChIP-Seq_ESCs_Human0.73018145
136VDR_21846776_ChIP-Seq_THP-1_Human0.70442900
137CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.69593356
138SALL4_18804426_ChIP-ChIP_XEN_Mouse0.69500988
139TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.69201052
140TBX20_22080862_ChIP-Seq_HEART_Mouse0.69072264
141TBX20_22328084_ChIP-Seq_HEART_Mouse0.69072264
142ESR1_20079471_ChIP-ChIP_T-47D_Human0.68129260
143ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.68108838
144CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.67972186
145* SOX2_20726797_ChIP-Seq_SW620_Human0.67863540
146PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.67497875
147TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.67454573
148GATA1_19941827_ChIP-Seq_MEL_Mouse0.67214341
149NRF2_20460467_ChIP-Seq_MEFs_Mouse0.66054954
150NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.66054954
151FOXA1_25552417_ChIP-Seq_VCAP_Human0.65710980
152PU.1_20513432_ChIP-Seq_Bcells_Mouse0.65414722
153OCT4_21477851_ChIP-Seq_ESCs_Mouse0.64721204
154TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.64258477
155SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.63339647
156* GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.63148793
157CRX_20693478_ChIP-Seq_RETINA_Mouse0.63015025
158TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.61778379
159P300_27268052_Chip-Seq_Bcells_Human0.60387690

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.19092904
2MP0005360_urolithiasis5.77153990
3MP0005365_abnormal_bile_salt4.76898125
4MP0005085_abnormal_gallbladder_physiolo4.70558636
5MP0008875_abnormal_xenobiotic_pharmacok3.88456097
6MP0003252_abnormal_bile_duct3.26257358
7MP0010329_abnormal_lipoprotein_level2.93061572
8MP0009333_abnormal_splenocyte_physiolog2.93028212
9MP0002138_abnormal_hepatobiliary_system2.67352125
10MP0009840_abnormal_foam_cell2.58032797
11MP0002148_abnormal_hypersensitivity_rea2.56294024
12MP0003806_abnormal_nucleotide_metabolis2.53403400
13MP0003191_abnormal_cellular_cholesterol2.50899051
14MP0002398_abnormal_bone_marrow2.47883933
15MP0005083_abnormal_biliary_tract2.46784062
16MP0003866_abnormal_defecation2.26104842
17MP0000703_abnormal_thymus_morphology2.20445301
18MP0002405_respiratory_system_inflammati2.20111134
19MP0001666_abnormal_nutrient_absorption2.18210899
20MP0000609_abnormal_liver_physiology2.07849068
21MP0005332_abnormal_amino_acid2.05381820
22MP0002254_reproductive_system_inflammat2.03866890
23MP0002722_abnormal_immune_system1.95046260
24MP0005310_abnormal_salivary_gland1.83469596
25* MP0002429_abnormal_blood_cell1.80436143
26MP0002118_abnormal_lipid_homeostasis1.76602202
27MP0003195_calcinosis1.75334011
28MP0003705_abnormal_hypodermis_morpholog1.73240886
29MP0004381_abnormal_hair_follicle1.68957074
30MP0001835_abnormal_antigen_presentation1.67650192
31MP0003300_gastrointestinal_ulcer1.67091979
32MP0002166_altered_tumor_susceptibility1.67045918
33MP0003045_fibrosis1.62765603
34MP0005319_abnormal_enzyme/_coenzyme1.59222363
35MP0003436_decreased_susceptibility_to1.57375462
36MP0004019_abnormal_vitamin_homeostasis1.52108418
37MP0003868_abnormal_feces_composition1.44815379
38MP0000569_abnormal_digit_pigmentation1.43988357
39MP0000685_abnormal_immune_system1.43191846
40MP0002163_abnormal_gland_morphology1.42628949
41MP0004130_abnormal_muscle_cell1.42276873
42MP0003724_increased_susceptibility_to1.40438448
43MP0009764_decreased_sensitivity_to1.39838996
44MP0008057_abnormal_DNA_replication1.37308429
45MP0005075_abnormal_melanosome_morpholog1.35258865
46MP0005584_abnormal_enzyme/coenzyme_acti1.31171521
47MP0008469_abnormal_protein_level1.27433066
48MP0001348_abnormal_lacrimal_gland1.27189346
49MP0001790_abnormal_immune_system1.27072335
50MP0005387_immune_system_phenotype1.27072335
51MP0009643_abnormal_urine_homeostasis1.26939831
52MP0005670_abnormal_white_adipose1.26642174
53MP0001800_abnormal_humoral_immune1.25958636
54MP0003303_peritoneal_inflammation1.23600016
55MP0010234_abnormal_vibrissa_follicle1.22946790
56MP0009785_altered_susceptibility_to1.18187003
57MP0002277_abnormal_respiratory_mucosa1.14019879
58MP0000598_abnormal_liver_morphology1.13888494
59MP0009763_increased_sensitivity_to1.13790870
60MP0005464_abnormal_platelet_physiology1.13338867
61MP0004947_skin_inflammation1.12758453
62MP0002396_abnormal_hematopoietic_system1.11560153
63MP0000604_amyloidosis1.10604555
64MP0001764_abnormal_homeostasis1.10471642
65MP0002006_tumorigenesis1.09532575
66MP0005025_abnormal_response_to1.07462410
67MP0002933_joint_inflammation1.04453717
68MP0002419_abnormal_innate_immunity1.01640463
69MP0005666_abnormal_adipose_tissue1.01474954
70MP0001873_stomach_inflammation0.99413521
71MP0005647_abnormal_sex_gland0.98919969
72MP0003656_abnormal_erythrocyte_physiolo0.97968444
73MP0005451_abnormal_body_composition0.97945356
74MP0001845_abnormal_inflammatory_respons0.97748124
75MP0010368_abnormal_lymphatic_system0.97656247
76MP0002971_abnormal_brown_adipose0.97449483
77MP0001853_heart_inflammation0.95775697
78MP0008438_abnormal_cutaneous_collagen0.95452829
79MP0002452_abnormal_antigen_presenting0.95284635
80MP0003448_altered_tumor_morphology0.95050257
81MP0010155_abnormal_intestine_physiology0.94240603
82MP0003183_abnormal_peptide_metabolism0.93936045
83MP0002723_abnormal_immune_serum0.93926938
84MP0005000_abnormal_immune_tolerance0.92406533
85MP0003186_abnormal_redox_activity0.92299630
86MP0002019_abnormal_tumor_incidence0.88548726
87MP0006082_CNS_inflammation0.87602349
88MP0004185_abnormal_adipocyte_glucose0.86256307
89MP0005058_abnormal_lysosome_morphology0.85769085
90MP0002136_abnormal_kidney_physiology0.85063553
91MP0005334_abnormal_fat_pad0.83540273
92MP0009765_abnormal_xenobiotic_induced0.82198627
93MP0003453_abnormal_keratinocyte_physiol0.80886380
94MP0005671_abnormal_response_to0.78924489
95MP0002693_abnormal_pancreas_physiology0.78691215
96MP0001533_abnormal_skeleton_physiology0.78360308
97MP0000465_gastrointestinal_hemorrhage0.77915813
98MP0001663_abnormal_digestive_system0.77406737
99* MP0009642_abnormal_blood_homeostasis0.77386861
100MP0002060_abnormal_skin_morphology0.76046293
101MP0000858_altered_metastatic_potential0.75824870
102MP0005379_endocrine/exocrine_gland_phen0.75120242
103MP0002420_abnormal_adaptive_immunity0.74870918
104MP0001819_abnormal_immune_cell0.74815610
105MP0001881_abnormal_mammary_gland0.74734901
106MP0005275_abnormal_skin_tensile0.73503456
107MP0000372_irregular_coat_pigmentation0.73281858
108MP0001756_abnormal_urination0.71339019
109MP0005023_abnormal_wound_healing0.68860220
110MP0000249_abnormal_blood_vessel0.68621458
111MP0003172_abnormal_lysosome_physiology0.68243900
112MP0000015_abnormal_ear_pigmentation0.67690396
113MP0009697_abnormal_copulation0.66957553
114MP0004510_myositis0.66826491
115MP0003566_abnormal_cell_adhesion0.66724556
116MP0002009_preneoplasia0.65771642
117MP0002078_abnormal_glucose_homeostasis0.65664581
118MP0005166_decreased_susceptibility_to0.65446161
119MP0002928_abnormal_bile_duct0.65198492
120MP0009115_abnormal_fat_cell0.64822355
121* MP0005636_abnormal_mineral_homeostasis0.64581626
122MP0003763_abnormal_thymus_physiology0.64253037
123MP0001919_abnormal_reproductive_system0.63399232
124MP0002796_impaired_skin_barrier0.62711324
125MP0001879_abnormal_lymphatic_vessel0.62499825
126* MP0000716_abnormal_immune_system0.62392067
127MP0002132_abnormal_respiratory_system0.62281876
128MP0001661_extended_life_span0.62161760
129MP0001851_eye_inflammation0.61766793
130MP0005645_abnormal_hypothalamus_physiol0.61671712
131MP0000689_abnormal_spleen_morphology0.61392602
132MP0003786_premature_aging0.61357839
133MP0001986_abnormal_taste_sensitivity0.60467805
134MP0010352_gastrointestinal_tract_polyps0.60154304
135MP0005220_abnormal_exocrine_pancreas0.60034961
136MP0002168_other_aberrant_phenotype0.59214359
137MP0004782_abnormal_surfactant_physiolog0.58762112
138MP0008877_abnormal_DNA_methylation0.56949695
139MP0008872_abnormal_physiological_respon0.56649906
140MP0005174_abnormal_tail_pigmentation0.53776097
141MP0008260_abnormal_autophagy0.50794577
142MP0008873_increased_physiological_sensi0.50103144
143MP0004883_abnormal_blood_vessel0.49280056
144MP0000490_abnormal_crypts_of0.49245536
145* MP0002998_abnormal_bone_remodeling0.47285944
146MP0004808_abnormal_hematopoietic_stem0.46198641
147MP0002095_abnormal_skin_pigmentation0.45461916
148MP0000371_diluted_coat_color0.44789357
149MP0005377_hearing/vestibular/ear_phenot0.44317096
150MP0003878_abnormal_ear_physiology0.44317096
151MP0003787_abnormal_imprinting0.41659769
152MP0001501_abnormal_sleep_pattern0.39630529
153MP0004142_abnormal_muscle_tone0.38108703
154MP0003646_muscle_fatigue0.37654260
155MP0002102_abnormal_ear_morphology0.35564642
156MP0002083_premature_death0.33911027

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)6.94774926
2Abnormality of T cell number (HP:0011839)6.62251450
3Deep venous thrombosis (HP:0002625)6.02000530
4Intrahepatic cholestasis (HP:0001406)5.59325278
5Abnormality of aromatic amino acid family metabolism (HP:0004338)5.36524664
6Xanthomatosis (HP:0000991)5.28084680
7Abnormal delayed hypersensitivity skin test (HP:0002963)5.27253725
8Abnormality of monocarboxylic acid metabolism (HP:0010996)5.19617198
9Abnormality of T cells (HP:0002843)5.19387776
10Elevated erythrocyte sedimentation rate (HP:0003565)5.12887530
11IgG deficiency (HP:0004315)4.98809237
12Complement deficiency (HP:0004431)4.96897889
13Prolonged partial thromboplastin time (HP:0003645)4.92909456
14Hypobetalipoproteinemia (HP:0003563)4.87687362
15Severe combined immunodeficiency (HP:0004430)4.63867475
16Retrobulbar optic neuritis (HP:0100654)4.59276437
17Optic neuritis (HP:0100653)4.59276437
18Stomatitis (HP:0010280)4.58313344
19Panhypogammaglobulinemia (HP:0003139)4.56152866
20Hyperlipoproteinemia (HP:0010980)4.51228747
21Agammaglobulinemia (HP:0004432)4.50316180
22Chronic mucocutaneous candidiasis (HP:0002728)4.49305824
23Recurrent cutaneous fungal infections (HP:0011370)4.49305824
24Recurrent fungal infections (HP:0002841)4.48905422
25Recurrent bronchitis (HP:0002837)4.43806800
26Myositis (HP:0100614)4.35032572
27Encephalitis (HP:0002383)4.26982717
28Joint hemorrhage (HP:0005261)4.26608327
29Meningitis (HP:0001287)4.25611971
30Autoimmune hemolytic anemia (HP:0001890)4.20611308
31Myocardial infarction (HP:0001658)4.08021341
32Epidermoid cyst (HP:0200040)4.07272038
33Orchitis (HP:0100796)4.07175889
34Vasculitis (HP:0002633)4.06126377
35Abnormality of the common coagulation pathway (HP:0010990)3.98700088
36Increased IgM level (HP:0003496)3.95423590
37Hypolipoproteinemia (HP:0010981)3.90572127
38Abnormality of eosinophils (HP:0001879)3.88380545
39Chronic diarrhea (HP:0002028)3.82118619
40Pulmonary infiltrates (HP:0002113)3.78079175
41Abnormality of glutamine family amino acid metabolism (HP:0010902)3.76158917
42Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.71269402
43Combined immunodeficiency (HP:0005387)3.68326276
44Hypoalphalipoproteinemia (HP:0003233)3.66067883
45Abnormality of complement system (HP:0005339)3.63187278
46Abnormality of T cell physiology (HP:0011840)3.62228492
47Hyperammonemia (HP:0001987)3.60002110
48Thyroiditis (HP:0100646)3.53735518
49Eosinophilia (HP:0001880)3.53663949
50Lymphopenia (HP:0001888)3.53620851
51Recurrent bacterial skin infections (HP:0005406)3.52422745
52Leukocytosis (HP:0001974)3.42624589
53Ketosis (HP:0001946)3.39558312
54Keratoconjunctivitis sicca (HP:0001097)3.37860772
55Abnormality of cells of the lymphoid lineage (HP:0012140)3.37429079
56Abnormality of sulfur amino acid metabolism (HP:0004339)3.33879558
57Fat malabsorption (HP:0002630)3.33448192
58Mediastinal lymphadenopathy (HP:0100721)3.29601526
59Recurrent skin infections (HP:0001581)3.27664445
60Recurrent abscess formation (HP:0002722)3.24859272
61Granulocytopenia (HP:0001913)3.22316607
62Hyperglycinuria (HP:0003108)3.21082266
63Keratoconjunctivitis (HP:0001096)3.19401818
64Abnormality of the intrinsic pathway (HP:0010989)3.18895949
65Abnormality of B cell number (HP:0010975)3.18248468
66Hypercholesterolemia (HP:0003124)3.15818037
67Hypoglycemic coma (HP:0001325)3.10080872
68Hypoplasia of the thymus (HP:0000778)3.08702893
69Abnormality of aspartate family amino acid metabolism (HP:0010899)3.07459112
70Recurrent gram-negative bacterial infections (HP:0005420)3.05462134
71Pustule (HP:0200039)3.04010355
72Hemoptysis (HP:0002105)3.03711921
73IgM deficiency (HP:0002850)3.02032236
74Hyperglycinemia (HP:0002154)3.01899272
75Abnormality of serine family amino acid metabolism (HP:0010894)2.99651468
76Abnormality of glycine metabolism (HP:0010895)2.99651468
77Abnormality of methionine metabolism (HP:0010901)2.98375299
78Hypoproteinemia (HP:0003075)2.95189577
79Systemic lupus erythematosus (HP:0002725)2.94893787
80Mitral stenosis (HP:0001718)2.92054108
81B lymphocytopenia (HP:0010976)2.90277996
82IgA deficiency (HP:0002720)2.88182778
83Esophageal varix (HP:0002040)2.85417366
84Gingival bleeding (HP:0000225)2.85205630
85Conjugated hyperbilirubinemia (HP:0002908)2.83536754
86Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.77007629
87Abnormality of fatty-acid metabolism (HP:0004359)2.76491508
88Lymphoma (HP:0002665)2.75148026
89Abnormality of macrophages (HP:0004311)2.72659901
90Bronchitis (HP:0012387)2.67632787
91Spontaneous abortion (HP:0005268)2.66633016
92Abnormality of pyrimidine metabolism (HP:0004353)2.65349797
93Gangrene (HP:0100758)2.63855723
94Obstructive lung disease (HP:0006536)2.61557179
95Chronic obstructive pulmonary disease (HP:0006510)2.61557179
96Skin nodule (HP:0200036)2.61387508
97Abnormality of the prostate (HP:0008775)2.61207416
98Chest pain (HP:0100749)2.60299617
99Hepatocellular carcinoma (HP:0001402)2.59059635
100Abnormality of nucleobase metabolism (HP:0010932)2.58877965
101Abnormality of the pleura (HP:0002103)2.58586756
102Gastrointestinal stroma tumor (HP:0100723)2.57808736
103Gastrointestinal inflammation (HP:0004386)2.57121576
104Abnormality of purine metabolism (HP:0004352)2.55642048
105Recurrent sinusitis (HP:0011108)2.52894015
106Chronic otitis media (HP:0000389)2.46914844
107Acanthocytosis (HP:0001927)2.46344220
108Steatorrhea (HP:0002570)2.46268493
109Ketoacidosis (HP:0001993)2.41601183
110Hyperbilirubinemia (HP:0002904)2.37788703
111Glomerulonephritis (HP:0000099)2.35178442
112Hypergammaglobulinemia (HP:0010702)2.34917985
113Menorrhagia (HP:0000132)2.34054415
114Arterial thrombosis (HP:0004420)2.34015479
115Anorexia (HP:0002039)2.32886795
116Spastic diplegia (HP:0001264)2.31274871
117Hemorrhage of the eye (HP:0011885)2.30664695
118Increased IgE level (HP:0003212)2.30479246
119Thrombophlebitis (HP:0004418)2.27087703
120Verrucae (HP:0200043)2.26905264
121Papilloma (HP:0012740)2.26905264
122Vascular calcification (HP:0004934)2.26851521
123Polycythemia (HP:0001901)2.26307293
124Increased mean platelet volume (HP:0011877)2.25950135
125Abnormality of proline metabolism (HP:0010907)2.24078643
126Hydroxyprolinuria (HP:0003080)2.24078643
127Stomach cancer (HP:0012126)2.23358557
128Amyloidosis (HP:0011034)2.20264344
129Abnormal platelet volume (HP:0011876)2.19988850
130Colitis (HP:0002583)2.18245614
131Cardiovascular calcification (HP:0011915)2.16145416
132Nephritis (HP:0000123)2.14600596
133Spontaneous hematomas (HP:0007420)2.14136046
134Aplastic anemia (HP:0001915)2.14057045
135Chronic sinusitis (HP:0011109)2.13875581
136Pulmonary embolism (HP:0002204)2.12061228
137Metabolic acidosis (HP:0001942)2.05490360
138Abnormality of iron homeostasis (HP:0011031)2.05467091
139Keratitis (HP:0000491)2.04283649
140Pancreatitis (HP:0001733)2.02974508
141Abnormality of serum amino acid levels (HP:0003112)2.02885871
142Hypertriglyceridemia (HP:0002155)2.02478329
143Abnormality of transition element cation homeostasis (HP:0011030)2.02470429
144Skin rash (HP:0000988)2.00697822
145Hematochezia (HP:0002573)1.99833742
146Hypochromic microcytic anemia (HP:0004840)1.99626231
147Basal cell carcinoma (HP:0002671)1.99141152
148Glomerulopathy (HP:0100820)1.98120566
149Eczematoid dermatitis (HP:0000976)1.96042830
150Epistaxis (HP:0000421)1.95180608
151Abnormal cartilage morphology (HP:0002763)1.92630402
152Hypochromic anemia (HP:0001931)1.92329269
153Autoimmune thrombocytopenia (HP:0001973)1.92105568
154Gingivitis (HP:0000230)1.90937905
155Sepsis (HP:0100806)1.90805518
156Recurrent viral infections (HP:0004429)1.89407563
157Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.86204475
158Polyneuropathy (HP:0001271)1.86065984
159Neutropenia (HP:0001875)1.85203479
160Alveolar cell carcinoma (HP:0006519)1.84987850
161Sensorimotor neuropathy (HP:0007141)1.84817683
162Urticaria (HP:0001025)1.84236350
163Abnormality of dicarboxylic acid metabolism (HP:0010995)1.84192300
164Dicarboxylic aciduria (HP:0003215)1.84192300
165Gastrointestinal infarctions (HP:0005244)1.83926981
166Stroke (HP:0001297)1.83461732
167Neoplasm of the tracheobronchial system (HP:0100552)1.80774806
168Recurrent otitis media (HP:0000403)1.80685684
169Malnutrition (HP:0004395)1.80083684
170Delayed CNS myelination (HP:0002188)1.79870808
171Gout (HP:0001997)1.79646781
172Abnormal gallbladder morphology (HP:0012437)1.79276776
173Cholelithiasis (HP:0001081)1.78854041
174Hypoglycemic seizures (HP:0002173)1.78699992
175Hemiplegia (HP:0002301)1.78560093
176Joint swelling (HP:0001386)1.78462408
177Arthralgia (HP:0002829)1.78106258
178Restrictive lung disease (HP:0002091)1.76554827
179Abnormality of the pericardium (HP:0001697)1.75377679
180Aplasia/Hypoplasia of the thymus (HP:0010515)1.73871471
181Peritonitis (HP:0002586)1.73250396
182Elevated hepatic transaminases (HP:0002910)1.71920483
183Neonatal onset (HP:0003623)1.71606291
184Acute hepatic failure (HP:0006554)1.71187940
185Conjunctival telangiectasia (HP:0000524)1.67737790
186Abnormal platelet function (HP:0011869)1.66070277
187Impaired platelet aggregation (HP:0003540)1.66070277
188Abnormality of the vasculature of the conjunctiva (HP:0008054)1.65600260
189Inflammation of the large intestine (HP:0002037)1.64274330

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FGFR43.67238069
2ERN13.52717815
3SIK13.12382811
4TYK22.98279414
5BCKDK2.94042396
6RIPK42.72853357
7FES2.49897755
8TRIB32.36111015
9MAP3K142.34251447
10JAK12.32353470
11MAP4K12.26717059
12FRK2.14661828
13MAP3K102.12530523
14TAOK32.12511201
15PKN22.01574027
16FGFR31.97227356
17TBK11.96527659
18JAK31.89039523
19IKBKE1.79283989
20GRK61.73361555
21TGFBR21.68947615
22TTN1.63958332
23PTK61.59723850
24CAMK1D1.55864568
25FGFR21.52055521
26EPHB11.46408601
27CAMKK21.43496033
28NEK91.40635764
29JAK21.39830567
30RIPK11.37468706
31FLT31.36825365
32CSK1.36717504
33INSRR1.36271696
34MAP3K131.33527332
35MST41.32196787
36PASK1.31926253
37MST1R1.31797319
38CSF1R1.27170117
39MAP3K71.26913609
40MAPK111.24467540
41IRAK11.23890958
42PRPF4B1.23021764
43LATS11.22789157
44KIT1.22303094
45TNK21.21701183
46PRKAA21.21099685
47MAP2K31.20734394
48IRAK31.20712551
49PIK3CG1.19956576
50LRRK21.18524721
51IKBKB1.17866093
52ITK1.14228002
53ADRBK21.11654982
54EPHA31.09522629
55ZAP701.09448097
56STK101.08060883
57KDR0.98456190
58SIK30.97055078
59TIE10.96089399
60BMPR20.94978854
61ERBB40.92942629
62EEF2K0.90980803
63MAP2K60.90206083
64BLK0.89120100
65CHUK0.88149064
66TLK10.86143357
67CAMK1G0.85586806
68EIF2AK30.84800133
69GRK70.83189558
70TESK20.82686001
71MAP3K30.82648131
72BTK0.82575407
73CDK60.77775676
74CAMKK10.73497072
75TYRO30.73379627
76SYK0.72974800
77HIPK20.72160501
78HCK0.70841265
79PRKCQ0.70287690
80TXK0.70287555
81LCK0.66893957
82MAPK120.64914914
83SIK20.64713735
84TEC0.64546693
85IRAK40.62124711
86NLK0.61878557
87SGK30.61830894
88PDGFRA0.61429738
89PIM10.60807475
90CLK10.58781924
91PIK3CA0.58442404
92STK30.57233392
93MAPK40.54777001
94DYRK1B0.53652877
95NUAK10.52898834
96GSK3A0.51862091
97RET0.51733957
98TRPM70.51534214
99PRKAA10.51237795
100PDK10.50738262
101PKN10.50324683
102PDPK10.50247455
103FYN0.49773705
104MAP3K110.49758796
105EGFR0.49397103
106MAP3K10.47910501
107RPS6KA50.47683825
108FGR0.46598165
109BMX0.45124038
110PDGFRB0.44566346
111STK40.43547717
112MAPK70.43235521
113PRKCH0.41300599
114CDK90.41242608
115LYN0.40056594
116MARK30.38650728
117IGF1R0.38591665
118ABL10.38390741
119CDK40.38190968
120MAPKAPK20.37928767
121SGK20.37424768
122MTOR0.37244068
123MATK0.37235222
124MELK0.34979853
125RPS6KA40.34968998
126PRKD10.32791865
127MAP3K20.30877130
128ACVR1B0.30876825
129ZAK0.29990433
130OBSCN0.29558912
131MAPKAPK30.29481844
132INSR0.29058314
133GRK10.25597726
134NEK60.23442860
135TAOK20.21767595
136ADRBK10.19977101
137MAPK30.17787683

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.27821276
2Graft-versus-host disease_Homo sapiens_hsa053324.00175205
3Allograft rejection_Homo sapiens_hsa053303.99157038
4Autoimmune thyroid disease_Homo sapiens_hsa053203.97482625
5Nitrogen metabolism_Homo sapiens_hsa009103.46697981
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.25709162
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.09248809
8Type I diabetes mellitus_Homo sapiens_hsa049402.96109278
9Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.90744191
10Arginine biosynthesis_Homo sapiens_hsa002202.87207254
11T cell receptor signaling pathway_Homo sapiens_hsa046602.82497822
12Complement and coagulation cascades_Homo sapiens_hsa046102.80647280
13Caffeine metabolism_Homo sapiens_hsa002322.69386702
14Tryptophan metabolism_Homo sapiens_hsa003802.63544794
15Asthma_Homo sapiens_hsa053102.59622576
16Fatty acid degradation_Homo sapiens_hsa000712.55043545
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.29678425
18Staphylococcus aureus infection_Homo sapiens_hsa051502.29153439
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.25581746
20PPAR signaling pathway_Homo sapiens_hsa033202.17510515
21Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.14587024
22Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.13358811
23Pentose and glucuronate interconversions_Homo sapiens_hsa000402.11512194
24Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.97012377
25Peroxisome_Homo sapiens_hsa041461.93934346
26Propanoate metabolism_Homo sapiens_hsa006401.91381873
27Viral myocarditis_Homo sapiens_hsa054161.85936956
28Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.84302240
29Fatty acid metabolism_Homo sapiens_hsa012121.77589089
30Histidine metabolism_Homo sapiens_hsa003401.70937691
31Chemical carcinogenesis_Homo sapiens_hsa052041.67782804
32Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.61712338
33Butanoate metabolism_Homo sapiens_hsa006501.59312729
34Herpes simplex infection_Homo sapiens_hsa051681.57827075
35beta-Alanine metabolism_Homo sapiens_hsa004101.56784156
36Steroid hormone biosynthesis_Homo sapiens_hsa001401.53063921
37Selenocompound metabolism_Homo sapiens_hsa004501.49485274
38Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.48626785
39Drug metabolism - other enzymes_Homo sapiens_hsa009831.47066017
40Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.45242934
41Retinol metabolism_Homo sapiens_hsa008301.43710026
42Phenylalanine metabolism_Homo sapiens_hsa003601.39179574
43ABC transporters_Homo sapiens_hsa020101.39058784
44Bile secretion_Homo sapiens_hsa049761.38725224
45Rheumatoid arthritis_Homo sapiens_hsa053231.37162682
46Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.30945741
472-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.30535659
48Starch and sucrose metabolism_Homo sapiens_hsa005001.27614475
49Chemokine signaling pathway_Homo sapiens_hsa040621.26345707
50Fat digestion and absorption_Homo sapiens_hsa049751.17431326
51Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.14824639
52Tyrosine metabolism_Homo sapiens_hsa003501.14143283
53Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.13980045
54Tuberculosis_Homo sapiens_hsa051521.13081490
55Sulfur metabolism_Homo sapiens_hsa009201.10379381
56Pyruvate metabolism_Homo sapiens_hsa006201.08181669
57Epstein-Barr virus infection_Homo sapiens_hsa051691.04437110
58Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.99890146
59Lysine degradation_Homo sapiens_hsa003100.97621653
60Hepatitis B_Homo sapiens_hsa051610.96885555
61Fatty acid biosynthesis_Homo sapiens_hsa000610.94043048
62Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.92950198
63Proteasome_Homo sapiens_hsa030500.92750008
64Apoptosis_Homo sapiens_hsa042100.90569223
65Carbon metabolism_Homo sapiens_hsa012000.90222543
66Folate biosynthesis_Homo sapiens_hsa007900.86181687
67Cysteine and methionine metabolism_Homo sapiens_hsa002700.85628145
68Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.81227146
69Sulfur relay system_Homo sapiens_hsa041220.81182404
70Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.80947485
71Glycerolipid metabolism_Homo sapiens_hsa005610.80776810
72Fatty acid elongation_Homo sapiens_hsa000620.80253625
73Biosynthesis of amino acids_Homo sapiens_hsa012300.79596153
74Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.78485884
75HTLV-I infection_Homo sapiens_hsa051660.78472810
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.76137698
77Insulin resistance_Homo sapiens_hsa049310.75233840
78Legionellosis_Homo sapiens_hsa051340.70599829
79Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.68521008
80Vitamin digestion and absorption_Homo sapiens_hsa049770.68207719
81NF-kappa B signaling pathway_Homo sapiens_hsa040640.65975081
82Viral carcinogenesis_Homo sapiens_hsa052030.65791591
83African trypanosomiasis_Homo sapiens_hsa051430.65184395
84Shigellosis_Homo sapiens_hsa051310.60729081
85Steroid biosynthesis_Homo sapiens_hsa001000.59836534
86Arginine and proline metabolism_Homo sapiens_hsa003300.58980101
87Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.58007415
88Cyanoamino acid metabolism_Homo sapiens_hsa004600.57320101
89Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.57111691
90Maturity onset diabetes of the young_Homo sapiens_hsa049500.55714713
91Primary immunodeficiency_Homo sapiens_hsa053400.54714787
92Platelet activation_Homo sapiens_hsa046110.52766894
93Intestinal immune network for IgA production_Homo sapiens_hsa046720.50540091
94RNA degradation_Homo sapiens_hsa030180.50422723
95Non-small cell lung cancer_Homo sapiens_hsa052230.50317753
96Pentose phosphate pathway_Homo sapiens_hsa000300.49972082
97Regulation of autophagy_Homo sapiens_hsa041400.49260759
98alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.45715224
99B cell receptor signaling pathway_Homo sapiens_hsa046620.45548426
100Transcriptional misregulation in cancer_Homo sapiens_hsa052020.45505355
101Prolactin signaling pathway_Homo sapiens_hsa049170.44520421
102SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44429530
103RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.43997167
104Linoleic acid metabolism_Homo sapiens_hsa005910.43190535
105Leishmaniasis_Homo sapiens_hsa051400.41917319
106Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.41727735
107Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.39853743
108One carbon pool by folate_Homo sapiens_hsa006700.39803423
109Osteoclast differentiation_Homo sapiens_hsa043800.39111548
110Phototransduction_Homo sapiens_hsa047440.38043599
111Leukocyte transendothelial migration_Homo sapiens_hsa046700.36951547
112Toll-like receptor signaling pathway_Homo sapiens_hsa046200.36367520
113Salmonella infection_Homo sapiens_hsa051320.36059173
114Pancreatic cancer_Homo sapiens_hsa052120.35825811
115Measles_Homo sapiens_hsa051620.35030076
116Hepatitis C_Homo sapiens_hsa051600.34964652
117Glutathione metabolism_Homo sapiens_hsa004800.34084220
118Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.33273849
119FoxO signaling pathway_Homo sapiens_hsa040680.31505318
120Toxoplasmosis_Homo sapiens_hsa051450.31075085
121Homologous recombination_Homo sapiens_hsa034400.30828382
122RNA polymerase_Homo sapiens_hsa030200.29793267
123Vitamin B6 metabolism_Homo sapiens_hsa007500.29761722
124VEGF signaling pathway_Homo sapiens_hsa043700.29585738
125MAPK signaling pathway_Homo sapiens_hsa040100.27826820
126Phagosome_Homo sapiens_hsa041450.27206388
127AMPK signaling pathway_Homo sapiens_hsa041520.26225343
128Dorso-ventral axis formation_Homo sapiens_hsa043200.25301417
129Malaria_Homo sapiens_hsa051440.25249189
130Prion diseases_Homo sapiens_hsa050200.24296735
131Pertussis_Homo sapiens_hsa051330.23366092
132Systemic lupus erythematosus_Homo sapiens_hsa053220.23190914
133Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.22546166
134Sphingolipid signaling pathway_Homo sapiens_hsa040710.22341669
135TNF signaling pathway_Homo sapiens_hsa046680.21787787
136Jak-STAT signaling pathway_Homo sapiens_hsa046300.21766828
137Ribosome_Homo sapiens_hsa030100.21095848
138Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.21076674
139Renin-angiotensin system_Homo sapiens_hsa046140.20528856
140Antigen processing and presentation_Homo sapiens_hsa046120.20044590
141Influenza A_Homo sapiens_hsa051640.19595610
142AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.18331788
143Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.18304781
144Galactose metabolism_Homo sapiens_hsa000520.17445656
145Protein export_Homo sapiens_hsa030600.17213189
146Neurotrophin signaling pathway_Homo sapiens_hsa047220.16471575
147Metabolic pathways_Homo sapiens_hsa011000.15626336
148Fanconi anemia pathway_Homo sapiens_hsa034600.15188524
149Amoebiasis_Homo sapiens_hsa051460.14812633
150Phosphatidylinositol signaling system_Homo sapiens_hsa040700.14604115
151NOD-like receptor signaling pathway_Homo sapiens_hsa046210.14445241
152Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.14349295
153Acute myeloid leukemia_Homo sapiens_hsa052210.14184368
154Glucagon signaling pathway_Homo sapiens_hsa049220.14182622
155Fructose and mannose metabolism_Homo sapiens_hsa000510.12905893
156Insulin signaling pathway_Homo sapiens_hsa049100.12730923
157Hematopoietic cell lineage_Homo sapiens_hsa046400.12455009
158Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.12197973
159Spliceosome_Homo sapiens_hsa030400.12112877
160Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.11551005
161Endocytosis_Homo sapiens_hsa041440.09907561
162Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.09355722
163Chronic myeloid leukemia_Homo sapiens_hsa052200.08577601
164Carbohydrate digestion and absorption_Homo sapiens_hsa049730.07979998
165Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.07369204
166Ras signaling pathway_Homo sapiens_hsa040140.07310231
167Ether lipid metabolism_Homo sapiens_hsa005650.06894041
168Basal transcription factors_Homo sapiens_hsa030220.05901817
169Glycerophospholipid metabolism_Homo sapiens_hsa005640.05486317
170Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.05409370
171Colorectal cancer_Homo sapiens_hsa052100.03910198
172Non-homologous end-joining_Homo sapiens_hsa034500.03639762

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