CLEC2L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.18826984
2synaptic vesicle maturation (GO:0016188)5.87426958
3synaptic vesicle exocytosis (GO:0016079)5.55591949
4locomotory exploration behavior (GO:0035641)5.52117180
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.44681965
6glutamate secretion (GO:0014047)5.43752909
7neuronal action potential propagation (GO:0019227)5.38967847
8vocalization behavior (GO:0071625)5.27433526
9regulation of synaptic vesicle exocytosis (GO:2000300)5.17330255
10positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.06883302
11regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.04283709
12protein localization to synapse (GO:0035418)4.77838081
13ionotropic glutamate receptor signaling pathway (GO:0035235)4.72212282
14neurotransmitter secretion (GO:0007269)4.69011199
15regulation of synaptic vesicle transport (GO:1902803)4.59493571
16regulation of glutamate receptor signaling pathway (GO:1900449)4.51920863
17neuron cell-cell adhesion (GO:0007158)4.48436915
18synaptic vesicle docking involved in exocytosis (GO:0016081)4.46177303
19exploration behavior (GO:0035640)4.39806245
20layer formation in cerebral cortex (GO:0021819)4.38721600
21glutamate receptor signaling pathway (GO:0007215)4.32411819
22synaptic transmission, glutamatergic (GO:0035249)4.24500488
23L-amino acid import (GO:0043092)4.23898935
24proline transport (GO:0015824)4.23793954
25gamma-aminobutyric acid transport (GO:0015812)4.13607519
26regulation of long-term neuronal synaptic plasticity (GO:0048169)4.13135239
27cellular potassium ion homeostasis (GO:0030007)4.10603498
28regulation of neuronal synaptic plasticity (GO:0048168)4.09085256
29neuron-neuron synaptic transmission (GO:0007270)3.99933257
30cerebellar Purkinje cell differentiation (GO:0021702)3.97008189
31positive regulation of neurotransmitter secretion (GO:0001956)3.96099299
32regulation of synapse structural plasticity (GO:0051823)3.92879200
33positive regulation of dendritic spine morphogenesis (GO:0061003)3.88917874
34potassium ion homeostasis (GO:0055075)3.87648495
35positive regulation of dendritic spine development (GO:0060999)3.87524517
36positive regulation of synapse maturation (GO:0090129)3.86127396
37neurotransmitter transport (GO:0006836)3.78486293
38sodium ion export (GO:0071436)3.74872882
39positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.73323863
40membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.67941057
41amino acid import (GO:0043090)3.67089045
42regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.66576444
43neurofilament cytoskeleton organization (GO:0060052)3.66458390
44gamma-aminobutyric acid signaling pathway (GO:0007214)3.66334945
45neurotransmitter-gated ion channel clustering (GO:0072578)3.65654898
46long-term memory (GO:0007616)3.65315051
47synaptic vesicle endocytosis (GO:0048488)3.65055066
48neuromuscular process controlling posture (GO:0050884)3.63800129
49regulation of excitatory postsynaptic membrane potential (GO:0060079)3.63116566
50cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.61653793
51regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.60683920
52cerebellar granule cell differentiation (GO:0021707)3.60208303
53neuron recognition (GO:0008038)3.54068136
54activation of protein kinase A activity (GO:0034199)3.52528615
55cell migration in hindbrain (GO:0021535)3.52078027
56regulation of neurotransmitter levels (GO:0001505)3.50347861
57cellular sodium ion homeostasis (GO:0006883)3.50131332
58membrane depolarization during action potential (GO:0086010)3.49862542
59regulation of neurotransmitter secretion (GO:0046928)3.48873814
60neuronal ion channel clustering (GO:0045161)3.48865636
61potassium ion import (GO:0010107)3.48428974
62negative regulation of synaptic transmission, GABAergic (GO:0032229)3.47815940
63G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.45585717
64regulation of postsynaptic membrane potential (GO:0060078)3.44915247
65neuromuscular process controlling balance (GO:0050885)3.44342805
66positive regulation of membrane potential (GO:0045838)3.43281614
67regulation of ARF protein signal transduction (GO:0032012)3.41418644
68negative regulation of microtubule polymerization (GO:0031115)3.40764922
69regulation of vesicle fusion (GO:0031338)3.39600031
70cerebellar Purkinje cell layer development (GO:0021680)3.38825318
71transmission of nerve impulse (GO:0019226)3.38528568
72dendritic spine morphogenesis (GO:0060997)3.37782939
73response to pheromone (GO:0019236)3.37107568
74regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.36511936
75axon ensheathment in central nervous system (GO:0032291)3.36121409
76central nervous system myelination (GO:0022010)3.36121409
77cell communication by electrical coupling (GO:0010644)3.34937584
78regulation of synaptic plasticity (GO:0048167)3.34634879
79vesicle docking involved in exocytosis (GO:0006904)3.30960174
80negative regulation of heart rate (GO:0010459)3.30427016
81regulation of dendritic spine development (GO:0060998)3.23492982
82membrane depolarization (GO:0051899)3.22857622
83detection of calcium ion (GO:0005513)3.22607510
84dendritic spine organization (GO:0097061)3.22192575
85glycine transport (GO:0015816)3.21063277
86acidic amino acid transport (GO:0015800)3.19893184
87positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.19263185
88regulation of neurotransmitter transport (GO:0051588)3.19242725
89regulation of synaptic transmission, glutamatergic (GO:0051966)3.17934318
90postsynaptic membrane organization (GO:0001941)3.17452761
91negative regulation of dendrite morphogenesis (GO:0050774)3.15847650
92behavioral response to cocaine (GO:0048148)3.14917544
93innervation (GO:0060384)3.14726562
94long-term synaptic potentiation (GO:0060291)3.14662106
95vesicle transport along microtubule (GO:0047496)3.14508426
96dendrite morphogenesis (GO:0048813)3.13001481
97regulation of exocytosis (GO:0017157)3.12480473
98negative regulation of heart contraction (GO:0045822)3.12167230
99neurotransmitter uptake (GO:0001504)3.11295951
100chemosensory behavior (GO:0007635)3.10993609
101axon cargo transport (GO:0008088)3.10966555
102regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.09825709
103regulation of dendritic spine morphogenesis (GO:0061001)3.09161048
104adult walking behavior (GO:0007628)3.09019672
105axonal fasciculation (GO:0007413)3.07131643
106negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.07038398
107regulation of voltage-gated calcium channel activity (GO:1901385)3.05636548
108serotonin metabolic process (GO:0042428)3.05534294
109synapse assembly (GO:0007416)3.04849716
110synaptic transmission (GO:0007268)3.03150212
111negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.03138269
112positive regulation of synaptic transmission, GABAergic (GO:0032230)3.03066463
113positive regulation of potassium ion transmembrane transport (GO:1901381)3.03039358
114organelle transport along microtubule (GO:0072384)3.02367817
115neuromuscular process (GO:0050905)3.00401266
116regulation of synapse maturation (GO:0090128)2.98636479
117regulation of sensory perception of pain (GO:0051930)2.98329241
118regulation of sensory perception (GO:0051931)2.98329241
119response to auditory stimulus (GO:0010996)2.98223696
120mating behavior (GO:0007617)2.96935375
121cell differentiation in hindbrain (GO:0021533)2.96742513
122membrane hyperpolarization (GO:0060081)2.95915895
123regulation of synaptic transmission (GO:0050804)2.93619806
124regulation of female receptivity (GO:0045924)2.93507813
125positive regulation of neurotransmitter transport (GO:0051590)2.93317321
126vesicle docking (GO:0048278)2.92952824
127prepulse inhibition (GO:0060134)2.90408775
128behavioral defense response (GO:0002209)2.90326641
129behavioral fear response (GO:0001662)2.90326641

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.11897795
2GBX2_23144817_ChIP-Seq_PC3_Human3.33914517
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.26162364
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.20355800
5* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.16483802
6REST_21632747_ChIP-Seq_MESCs_Mouse2.88970001
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.87918399
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.87918399
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.79287092
10* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.65765882
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.65264653
12* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.62245632
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.62181543
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.61538073
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.49907871
16RARB_27405468_Chip-Seq_BRAIN_Mouse2.45853610
17DROSHA_22980978_ChIP-Seq_HELA_Human2.40331030
18REST_18959480_ChIP-ChIP_MESCs_Mouse2.36994143
19* EZH2_27294783_Chip-Seq_ESCs_Mouse2.35619421
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.33186888
21SUZ12_27294783_Chip-Seq_ESCs_Mouse2.30767586
22IKZF1_21737484_ChIP-ChIP_HCT116_Human2.28623663
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.24300196
24CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.05845719
25SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.02360041
26SRY_22984422_ChIP-ChIP_TESTIS_Rat1.99360561
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.97527530
28EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.93807559
29MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.89777309
30AR_21572438_ChIP-Seq_LNCaP_Human1.84626954
31TAF15_26573619_Chip-Seq_HEK293_Human1.80612792
32ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.75132278
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.71797433
34ERG_21242973_ChIP-ChIP_JURKAT_Human1.71516926
35GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.70136629
36SMAD4_21799915_ChIP-Seq_A2780_Human1.64084641
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.57134001
38SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.50713914
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.44794583
40ZNF274_21170338_ChIP-Seq_K562_Hela1.44054514
41NR3C1_23031785_ChIP-Seq_PC12_Mouse1.40173996
42ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.40053370
43PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.37966414
44* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.36454722
45RING1B_27294783_Chip-Seq_ESCs_Mouse1.34139430
46BMI1_23680149_ChIP-Seq_NPCS_Mouse1.33399757
47SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.30465940
48P300_19829295_ChIP-Seq_ESCs_Human1.29832965
49* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29760066
50ZFP57_27257070_Chip-Seq_ESCs_Mouse1.29249937
51SOX2_21211035_ChIP-Seq_LN229_Gbm1.27933813
52RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.27867399
53AR_25329375_ChIP-Seq_VCAP_Human1.26235267
54LXR_22292898_ChIP-Seq_THP-1_Human1.24917172
55CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.22851345
56DNAJC2_21179169_ChIP-ChIP_NT2_Human1.21816125
57LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.20218489
58* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.19394439
59AR_19668381_ChIP-Seq_PC3_Human1.18719491
60IGF1R_20145208_ChIP-Seq_DFB_Human1.17698405
61CBX2_27304074_Chip-Seq_ESCs_Mouse1.15022243
62STAT3_23295773_ChIP-Seq_U87_Human1.14939909
63KDM2B_26808549_Chip-Seq_K562_Human1.14894489
64* SMAD3_21741376_ChIP-Seq_EPCs_Human1.14565177
65GATA1_26923725_Chip-Seq_HPCs_Mouse1.12470848
66CDX2_19796622_ChIP-Seq_MESCs_Mouse1.10865520
67RING1B_27294783_Chip-Seq_NPCs_Mouse1.10189148
68OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09469957
69SMAD_19615063_ChIP-ChIP_OVARY_Human1.09389916
70GATA1_19941826_ChIP-Seq_K562_Human1.09380982
71TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09172992
72SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08864185
73* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.07407914
74GATA1_22025678_ChIP-Seq_K562_Human1.06929951
75TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06599227
76RNF2_27304074_Chip-Seq_NSC_Mouse1.06481239
77ZFP281_18757296_ChIP-ChIP_E14_Mouse1.06062056
78KDM2B_26808549_Chip-Seq_SUP-B15_Human1.05425950
79GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04700488
80EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.04442525
81PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.03547386
82PIAS1_25552417_ChIP-Seq_VCAP_Human1.02309456
83TCF4_23295773_ChIP-Seq_U87_Human1.01875841
84ARNT_22903824_ChIP-Seq_MCF-7_Human1.01820908
85WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.01530289
86SMAD3_21741376_ChIP-Seq_ESCs_Human1.00904449
87GATA1_19941827_ChIP-Seq_MEL_Mouse1.00534173
88P53_22127205_ChIP-Seq_FIBROBLAST_Human0.99802694
89AHR_22903824_ChIP-Seq_MCF-7_Human0.99542054
90GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99175469
91YAP1_20516196_ChIP-Seq_MESCs_Mouse0.98579763
92TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.98523098
93DPY_21335234_ChIP-Seq_ESCs_Mouse0.97729785
94TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.97684575
95MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95654621
96ZNF217_24962896_ChIP-Seq_MCF-7_Human0.94395248
97RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.94324286
98RUNX2_22187159_ChIP-Seq_PCA_Human0.93026807
99KLF4_19829295_ChIP-Seq_ESCs_Human0.92535768
100PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.91985621
101ESR2_21235772_ChIP-Seq_MCF-7_Human0.91337307
102PRDM14_20953172_ChIP-Seq_ESCs_Human0.91154471
103ZFP281_27345836_Chip-Seq_ESCs_Mouse0.90728439
104POU3F2_20337985_ChIP-ChIP_501MEL_Human0.90706758
105OCT4_19829295_ChIP-Seq_ESCs_Human0.90576952
106TET1_21490601_ChIP-Seq_MESCs_Mouse0.90450162
107RUNX1_26923725_Chip-Seq_HPCs_Mouse0.90205024
108SMAD4_21741376_ChIP-Seq_HESCs_Human0.89489584
109SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.89445291
110AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.88137352
111SMC4_20622854_ChIP-Seq_HELA_Human0.87837705
112UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.87575644
113GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87456953
114TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87205536
115P68_20966046_ChIP-Seq_HELA_Human0.87062862
116PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.86553702
117SCL_19346495_ChIP-Seq_HPC-7_Human0.84846505
118VDR_22108803_ChIP-Seq_LS180_Human0.84249408
119CTCF_27219007_Chip-Seq_Bcells_Human0.83831877
120BCAT_22108803_ChIP-Seq_LS180_Human0.83795310
121JUN_21703547_ChIP-Seq_K562_Human0.83579315
122TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83238325
123POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.83238325
124THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.83110196
125SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.82386140
126OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.82159576
127SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.82003284
128GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.81946431
129ELK4_26923725_Chip-Seq_MESODERM_Mouse0.78660372
130VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.76412392
131GATA2_19941826_ChIP-Seq_K562_Human0.75640203
132MYC_19915707_ChIP-ChIP_AK7_Human0.75357722
133SMAD4_21741376_ChIP-Seq_ESCs_Human0.75040447
134SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.72877711
135FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.72741555
136TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.72424681
137LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.69726738

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.27777329
2MP0003880_abnormal_central_pattern4.66772481
3MP0003635_abnormal_synaptic_transmissio4.10567473
4MP0004270_analgesia3.84171809
5MP0009046_muscle_twitch3.49383705
6MP0001968_abnormal_touch/_nociception3.46692254
7MP0009745_abnormal_behavioral_response3.30478461
8MP0002063_abnormal_learning/memory/cond3.20828562
9MP0002064_seizures3.17688797
10MP0002735_abnormal_chemical_nociception3.12858311
11MP0002736_abnormal_nociception_after2.96368872
12MP0002734_abnormal_mechanical_nocicepti2.94237652
13MP0002272_abnormal_nervous_system2.92300432
14MP0002572_abnormal_emotion/affect_behav2.71806247
15MP0005423_abnormal_somatic_nervous2.70405115
16MP0002733_abnormal_thermal_nociception2.43908292
17MP0001486_abnormal_startle_reflex2.40653631
18MP0001501_abnormal_sleep_pattern2.32170742
19MP0001440_abnormal_grooming_behavior2.27329833
20MP0002067_abnormal_sensory_capabilities2.26550872
21MP0001970_abnormal_pain_threshold2.25174768
22MP0008569_lethality_at_weaning2.14908518
23MP0004858_abnormal_nervous_system2.14775229
24MP0002184_abnormal_innervation2.11264923
25MP0006276_abnormal_autonomic_nervous2.07816808
26MP0002822_catalepsy2.07276627
27MP0003329_amyloid_beta_deposits2.02355183
28MP0004811_abnormal_neuron_physiology1.89468666
29MP0000955_abnormal_spinal_cord1.81735811
30MP0000778_abnormal_nervous_system1.79658162
31MP0005464_abnormal_platelet_physiology1.78173588
32MP0004924_abnormal_behavior1.77911527
33MP0005386_behavior/neurological_phenoty1.77911527
34MP0002557_abnormal_social/conspecific_i1.73574734
35MP0009780_abnormal_chondrocyte_physiolo1.62971967
36MP0002909_abnormal_adrenal_gland1.56918830
37MP0003879_abnormal_hair_cell1.55398296
38MP0002066_abnormal_motor_capabilities/c1.51317044
39MP0002882_abnormal_neuron_morphology1.50824182
40MP0004142_abnormal_muscle_tone1.48397519
41MP0004145_abnormal_muscle_electrophysio1.38528593
42MP0001984_abnormal_olfaction1.35072268
43MP0003633_abnormal_nervous_system1.34575572
44MP0004885_abnormal_endolymph1.33566629
45MP0003631_nervous_system_phenotype1.19065258
46MP0002229_neurodegeneration1.17504965
47MP0005645_abnormal_hypothalamus_physiol1.17485010
48MP0000751_myopathy1.12937097
49MP0001502_abnormal_circadian_rhythm1.10579694
50MP0002152_abnormal_brain_morphology1.08537980
51MP0001905_abnormal_dopamine_level1.07183376
52MP0003123_paternal_imprinting1.06562689
53MP0004742_abnormal_vestibular_system1.06465785
54MP0005646_abnormal_pituitary_gland1.04212003
55MP0003787_abnormal_imprinting1.03183516
56MP0003122_maternal_imprinting0.98635021
57MP0005167_abnormal_blood-brain_barrier0.97138859
58MP0001529_abnormal_vocalization0.95958530
59MP0003632_abnormal_nervous_system0.94735747
60MP0003634_abnormal_glial_cell0.94592672
61MP0004130_abnormal_muscle_cell0.92791634
62MP0000604_amyloidosis0.92045065
63MP0008872_abnormal_physiological_respon0.91911908
64MP0005551_abnormal_eye_electrophysiolog0.90849889
65MP0002752_abnormal_somatic_nervous0.89819926
66MP0000920_abnormal_myelination0.89225011
67MP0008874_decreased_physiological_sensi0.86158546
68MP0002069_abnormal_eating/drinking_beha0.85552862
69MP0001188_hyperpigmentation0.84999873
70MP0010386_abnormal_urinary_bladder0.84491656
71MP0001963_abnormal_hearing_physiology0.83389714
72MP0008004_abnormal_stomach_pH0.82351341
73MP0001986_abnormal_taste_sensitivity0.80160033
74MP0005535_abnormal_body_temperature0.79747236
75MP0004085_abnormal_heartbeat0.78074487
76MP0002837_dystrophic_cardiac_calcinosis0.76859005
77MP0002638_abnormal_pupillary_reflex0.76708149
78MP0005623_abnormal_meninges_morphology0.76104397
79MP0001348_abnormal_lacrimal_gland0.76035915
80MP0001299_abnormal_eye_distance/0.75854696
81MP0000569_abnormal_digit_pigmentation0.75624183
82MP0004484_altered_response_of0.75139098
83MP0005499_abnormal_olfactory_system0.73192606
84MP0005394_taste/olfaction_phenotype0.73192606
85MP0004510_myositis0.72274600
86MP0000013_abnormal_adipose_tissue0.71867689
87MP0004215_abnormal_myocardial_fiber0.71582526
88MP0006035_abnormal_mitochondrial_morpho0.70979138
89MP0001346_abnormal_lacrimal_gland0.69301133
90MP0003690_abnormal_glial_cell0.67123621
91MP0001765_abnormal_ion_homeostasis0.65391019
92MP0003283_abnormal_digestive_organ0.64690045
93MP0002090_abnormal_vision0.64525553
94MP0001177_atelectasis0.63380267
95MP0004147_increased_porphyrin_level0.63187472
96MP0004233_abnormal_muscle_weight0.61742541
97MP0000631_abnormal_neuroendocrine_gland0.60321221
98MP0003137_abnormal_impulse_conducting0.60068687
99MP0005166_decreased_susceptibility_to0.59734226
100MP0000747_muscle_weakness0.59647394
101MP0008877_abnormal_DNA_methylation0.59061857
102MP0008961_abnormal_basal_metabolism0.58360501
103MP0005187_abnormal_penis_morphology0.58086484
104MP0005410_abnormal_fertilization0.57464671
105MP0001485_abnormal_pinna_reflex0.57442432
106MP0005409_darkened_coat_color0.56654757
107MP0003861_abnormal_nervous_system0.55985418
108MP0001943_abnormal_respiration0.55870296
109MP0010769_abnormal_survival0.55234186
110MP0010770_preweaning_lethality0.53547883
111MP0002082_postnatal_lethality0.53547883
112MP0003075_altered_response_to0.53238294
113MP0002751_abnormal_autonomic_nervous0.53080410
114MP0003638_abnormal_response/metabolism_0.49513843
115MP0002873_normal_phenotype0.48451968
116MP0002169_no_abnormal_phenotype0.46978050
117MP0003956_abnormal_body_size0.46635207
118MP0004036_abnormal_muscle_relaxation0.46480748
119MP0000230_abnormal_systemic_arterial0.44271199
120MP0002083_premature_death0.44261745
121MP0003172_abnormal_lysosome_physiology0.43714263
122MP0010768_mortality/aging0.42357222
123MP0000579_abnormal_nail_morphology0.42012353
124MP0002089_abnormal_postnatal_growth/wei0.42001220

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)7.18416361
2Focal motor seizures (HP:0011153)7.06324317
3Visual hallucinations (HP:0002367)5.76473406
4Focal seizures (HP:0007359)5.58674839
5Atonic seizures (HP:0010819)5.21477397
6Progressive cerebellar ataxia (HP:0002073)4.90609187
7Febrile seizures (HP:0002373)4.87376046
8Epileptic encephalopathy (HP:0200134)4.71329735
9Action tremor (HP:0002345)4.70010675
10Absence seizures (HP:0002121)4.32823720
11Supranuclear gaze palsy (HP:0000605)4.20226065
12Generalized tonic-clonic seizures (HP:0002069)3.89698449
13Dialeptic seizures (HP:0011146)3.80574332
14Prolonged bleeding time (HP:0003010)3.78193515
15Gaze-evoked nystagmus (HP:0000640)3.54178499
16Menorrhagia (HP:0000132)3.52784876
17Increased mean platelet volume (HP:0011877)3.38767324
18Tetraplegia (HP:0002445)3.31738264
19Ankle clonus (HP:0011448)3.30505523
20Poor eye contact (HP:0000817)3.27474103
21Broad-based gait (HP:0002136)3.27266129
22Dysdiadochokinesis (HP:0002075)3.23600045
23Truncal ataxia (HP:0002078)3.23115473
24Purpura (HP:0000979)3.15670697
25Abnormal platelet volume (HP:0011876)3.15109615
26Cerebral hypomyelination (HP:0006808)3.11247310
27Dysmetria (HP:0001310)3.10807087
28Impaired vibration sensation in the lower limbs (HP:0002166)3.08758979
29Mutism (HP:0002300)3.07794517
30Impaired social interactions (HP:0000735)3.07292983
31Abnormal social behavior (HP:0012433)3.07292983
32Scanning speech (HP:0002168)3.06808812
33Amblyopia (HP:0000646)3.03725424
34Ulnar claw (HP:0001178)2.99906280
35Depression (HP:0000716)2.99301278
36Urinary bladder sphincter dysfunction (HP:0002839)2.94977888
37Termporal pattern (HP:0011008)2.92051650
38Insidious onset (HP:0003587)2.92051650
39Abnormal eating behavior (HP:0100738)2.90993781
40Urinary urgency (HP:0000012)2.88081902
41Pheochromocytoma (HP:0002666)2.85434795
42Abnormality of the lower motor neuron (HP:0002366)2.83079451
43Impaired smooth pursuit (HP:0007772)2.80820034
44Anxiety (HP:0000739)2.78351086
45Abnormality of binocular vision (HP:0011514)2.74964448
46Diplopia (HP:0000651)2.74964448
47Abnormality of the corticospinal tract (HP:0002492)2.74747625
48Ventricular fibrillation (HP:0001663)2.68501783
49Genetic anticipation (HP:0003743)2.68031246
50Progressive inability to walk (HP:0002505)2.67834773
51Hyperlipoproteinemia (HP:0010980)2.64118449
52Spastic gait (HP:0002064)2.63824191
53Clonus (HP:0002169)2.62863272
54Petechiae (HP:0000967)2.61400451
55Hemiparesis (HP:0001269)2.59708241
56Postural instability (HP:0002172)2.57892700
57Hyperventilation (HP:0002883)2.57702443
58Hemiplegia (HP:0002301)2.56160247
59Neuroendocrine neoplasm (HP:0100634)2.50253492
60Intention tremor (HP:0002080)2.49055355
61Abnormality of ocular smooth pursuit (HP:0000617)2.46856062
62Status epilepticus (HP:0002133)2.44964001
63Dysmetric saccades (HP:0000641)2.44357060
64Cerebral inclusion bodies (HP:0100314)2.43495907
65Obstructive sleep apnea (HP:0002870)2.41319127
66Drooling (HP:0002307)2.40500566
67Excessive salivation (HP:0003781)2.40500566
68Hyperthyroidism (HP:0000836)2.39612104
69Degeneration of the lateral corticospinal tracts (HP:0002314)2.38561508
70Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.38561508
71Limb dystonia (HP:0002451)2.36412264
72Rigidity (HP:0002063)2.33596111
73Papilledema (HP:0001085)2.31661633
74Neurofibrillary tangles (HP:0002185)2.30790258
75Bradykinesia (HP:0002067)2.30011171
76Epileptiform EEG discharges (HP:0011182)2.29968991
77Torticollis (HP:0000473)2.26668196
78Annular pancreas (HP:0001734)2.25671893
79Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.25490917
80Fetal akinesia sequence (HP:0001989)2.25132948
81EEG with generalized epileptiform discharges (HP:0011198)2.24871217
82Amyotrophic lateral sclerosis (HP:0007354)2.24829701
83Absent speech (HP:0001344)2.21216209
84Stereotypic behavior (HP:0000733)2.18561134
85Hypoventilation (HP:0002791)2.17968480
86Lower limb muscle weakness (HP:0007340)2.16304206
87Focal dystonia (HP:0004373)2.15799529
88Failure to thrive in infancy (HP:0001531)2.14495269
89Hypsarrhythmia (HP:0002521)2.13890665
90Lower limb amyotrophy (HP:0007210)2.11548463
91Inability to walk (HP:0002540)2.10189760
92Insomnia (HP:0100785)2.09072252
93Megalencephaly (HP:0001355)2.08214588
94Agitation (HP:0000713)2.07989768
95Epistaxis (HP:0000421)2.07427287
96Polyphagia (HP:0002591)2.04097332
97Gait ataxia (HP:0002066)2.03756125
98Generalized myoclonic seizures (HP:0002123)2.01705468
99Impaired vibratory sensation (HP:0002495)2.01635773
100Akinesia (HP:0002304)2.01290634
101Lower limb asymmetry (HP:0100559)1.98352414
102Neoplasm of the peripheral nervous system (HP:0100007)1.95702444
103Choreoathetosis (HP:0001266)1.95426688
104Aplasia/Hypoplasia of the brainstem (HP:0007362)1.94584624
105Hypoplasia of the brainstem (HP:0002365)1.94584624
106Postural tremor (HP:0002174)1.93577462
107Neuronal loss in central nervous system (HP:0002529)1.93307088
108Hammertoe (HP:0001765)1.92814462
109Craniofacial dystonia (HP:0012179)1.92107298
110Bundle branch block (HP:0011710)1.91465557
111Pointed chin (HP:0000307)1.91111763
112Peripheral hypomyelination (HP:0007182)1.90878758
113Abnormality of saccadic eye movements (HP:0000570)1.90558824
114Rapidly progressive (HP:0003678)1.90194509
115Morphological abnormality of the pyramidal tract (HP:0002062)1.89616996
116Limb ataxia (HP:0002070)1.89484978
117Psychosis (HP:0000709)1.89039404
118Delusions (HP:0000746)1.88885485
119Memory impairment (HP:0002354)1.88525471
120Apathy (HP:0000741)1.88315297
121Myotonia (HP:0002486)1.87493281
122CNS hypomyelination (HP:0003429)1.87322074
123Incomplete penetrance (HP:0003829)1.86952938
124Sleep apnea (HP:0010535)1.85777520
125Split foot (HP:0001839)1.78510550
126Slow progression (HP:0003677)1.77966399
127Spastic tetraparesis (HP:0001285)1.77584428
128Heart block (HP:0012722)1.72963509

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.48288819
2MAP3K93.83348473
3MINK13.38763587
4MAP3K43.16940896
5MARK13.16448569
6EPHA42.95565205
7MAP2K72.61865258
8MAP3K122.41082164
9RIPK42.35224029
10DAPK22.28530808
11PAK62.28262287
12KSR22.26362585
13MAP2K42.21480781
14CASK1.95887701
15CAMKK11.88847408
16GRK51.86925753
17NTRK11.84127877
18NTRK21.79154711
19PLK21.64604025
20PNCK1.60275546
21CDK191.59294596
22LATS21.49946989
23CDK51.48337122
24PRKD31.47175175
25CAMKK21.47015435
26STK381.45746266
27PHKG11.44756257
28PHKG21.44756257
29MAPK131.39277591
30MAP3K21.38316159
31LMTK21.37636637
32KSR11.36742109
33ARAF1.35168098
34SIK21.30688974
35DAPK11.27803720
36PRKCG1.27685105
37BMX1.18072547
38RET1.12208378
39MAP3K111.10715106
40WNK11.08202059
41UHMK11.03530790
42RIPK10.99653223
43PRPF4B0.99594772
44CAMK2A0.97117374
45CDK140.91271286
46FES0.91153624
47CDK180.89099679
48TNIK0.88855810
49CDK150.88376776
50TAOK10.84766858
51PINK10.84314555
52PKN10.83845174
53STK110.83823535
54SGK4940.80953537
55SGK2230.80953537
56CAMK10.80237841
57TYRO30.78688445
58BRSK10.78068885
59CDK11A0.77831249
60LIMK10.75003340
61PRKCH0.74708472
62BRAF0.74262728
63OXSR10.74211451
64PTK2B0.74024431
65DYRK1A0.72935728
66ALK0.71467176
67PAK30.71402115
68BMPR20.70592777
69SCYL20.70317441
70MAP3K130.69484038
71CSNK1G20.69363618
72RAF10.67298900
73MAP3K10.65184754
74CAMK2B0.64226926
75PDPK10.64042332
76PRKG20.63588920
77PDK10.63569812
78NEK60.61214128
79SGK20.58416364
80TNK20.57670433
81SGK10.56192122
82MAP2K10.54859162
83NEK10.54539392
84PRKCZ0.54499972
85CAMK2G0.53730873
86CCNB10.53531794
87PRKCE0.51601739
88MARK20.51590629
89FER0.51540303
90SGK30.50589044
91NME10.50542653
92SYK0.49246496
93PRKCA0.48822288
94STK390.47222216
95MYLK0.46888005
96TAOK20.45773748
97IRAK20.45709785
98PAK10.45451342
99CAMK2D0.43088305
100CDC42BPA0.42980406
101RPS6KA30.42685869
102MAPK100.42682283
103ROCK20.42675676
104RPS6KA20.42404409
105FGR0.42370799
106PRKG10.41674404
107FYN0.41372683
108WNK40.38655034
109TESK10.37952646
110ERBB20.35870582
111DAPK30.35425764
112ADRBK10.34101463
113MAPK120.33568956
114CAMK40.33512609
115JAK20.33487095
116SRC0.31214070
117EIF2AK10.30677633
118PRKCB0.30191439
119PRKACA0.30015767
120CAMK1G0.28908855

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.76292204
2Synaptic vesicle cycle_Homo sapiens_hsa047213.56636979
3Long-term potentiation_Homo sapiens_hsa047202.70298223
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.67213514
5GABAergic synapse_Homo sapiens_hsa047272.60448857
6Glutamatergic synapse_Homo sapiens_hsa047242.57836420
7Circadian entrainment_Homo sapiens_hsa047132.54692710
8Olfactory transduction_Homo sapiens_hsa047402.47895791
9Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.47622098
10Morphine addiction_Homo sapiens_hsa050322.34754021
11Amphetamine addiction_Homo sapiens_hsa050312.25831835
12Dopaminergic synapse_Homo sapiens_hsa047282.13321483
13Salivary secretion_Homo sapiens_hsa049702.08443598
14Taste transduction_Homo sapiens_hsa047421.95332034
15Long-term depression_Homo sapiens_hsa047301.90972467
16Insulin secretion_Homo sapiens_hsa049111.81822379
17Gastric acid secretion_Homo sapiens_hsa049711.81633369
18Cholinergic synapse_Homo sapiens_hsa047251.81500273
19Collecting duct acid secretion_Homo sapiens_hsa049661.73827428
20Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.71322872
21Aldosterone synthesis and secretion_Homo sapiens_hsa049251.68128629
22Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.63536302
23Serotonergic synapse_Homo sapiens_hsa047261.60397965
24Renin secretion_Homo sapiens_hsa049241.55139779
25Oxytocin signaling pathway_Homo sapiens_hsa049211.53970242
26Calcium signaling pathway_Homo sapiens_hsa040201.47883709
27Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.43073853
28GnRH signaling pathway_Homo sapiens_hsa049121.43057275
29Cocaine addiction_Homo sapiens_hsa050301.38393474
30Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.38186213
31Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.37275858
32Gap junction_Homo sapiens_hsa045401.34445628
33Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.33728566
34Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.27026702
35Phosphatidylinositol signaling system_Homo sapiens_hsa040701.17856454
36Estrogen signaling pathway_Homo sapiens_hsa049151.17741787
37Cardiac muscle contraction_Homo sapiens_hsa042601.16437134
38cAMP signaling pathway_Homo sapiens_hsa040241.16294567
39Type II diabetes mellitus_Homo sapiens_hsa049301.14532511
40Vibrio cholerae infection_Homo sapiens_hsa051101.12169108
41Glioma_Homo sapiens_hsa052141.09044807
42Platelet activation_Homo sapiens_hsa046111.07405926
43Axon guidance_Homo sapiens_hsa043601.06391209
44ErbB signaling pathway_Homo sapiens_hsa040121.02631094
45Vitamin B6 metabolism_Homo sapiens_hsa007500.95940571
46Melanogenesis_Homo sapiens_hsa049160.94732934
47Oocyte meiosis_Homo sapiens_hsa041140.94436330
48cGMP-PKG signaling pathway_Homo sapiens_hsa040220.94357416
49Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.93976559
50Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.93696024
51Dorso-ventral axis formation_Homo sapiens_hsa043200.91067968
52Phototransduction_Homo sapiens_hsa047440.85962584
53Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.84822942
54Pancreatic secretion_Homo sapiens_hsa049720.80814834
55Phospholipase D signaling pathway_Homo sapiens_hsa040720.80747940
56Vascular smooth muscle contraction_Homo sapiens_hsa042700.80376521
57Thyroid hormone synthesis_Homo sapiens_hsa049180.75423033
58Neurotrophin signaling pathway_Homo sapiens_hsa047220.71666604
59Alzheimers disease_Homo sapiens_hsa050100.70214126
60Choline metabolism in cancer_Homo sapiens_hsa052310.68800668
61VEGF signaling pathway_Homo sapiens_hsa043700.67739399
62MAPK signaling pathway_Homo sapiens_hsa040100.67149356
63Carbohydrate digestion and absorption_Homo sapiens_hsa049730.65143545
64Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.62414584
65Oxidative phosphorylation_Homo sapiens_hsa001900.61074686
66Dilated cardiomyopathy_Homo sapiens_hsa054140.60214740
67Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.58862959
68Glucagon signaling pathway_Homo sapiens_hsa049220.55986132
69Sphingolipid signaling pathway_Homo sapiens_hsa040710.55730615
70Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55531469
71Ras signaling pathway_Homo sapiens_hsa040140.51544162
72Inositol phosphate metabolism_Homo sapiens_hsa005620.51419511
73mTOR signaling pathway_Homo sapiens_hsa041500.48607328
74Bile secretion_Homo sapiens_hsa049760.47671063
75Parkinsons disease_Homo sapiens_hsa050120.47524666
76Rap1 signaling pathway_Homo sapiens_hsa040150.46350954
77Thyroid hormone signaling pathway_Homo sapiens_hsa049190.46263353
78Endocytosis_Homo sapiens_hsa041440.46163710
79Insulin signaling pathway_Homo sapiens_hsa049100.45836567
80Endometrial cancer_Homo sapiens_hsa052130.43941917
81Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.43852617
82Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.43463087
83Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.43135707
84Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.42420350
85Alcoholism_Homo sapiens_hsa050340.41259554
86Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.41090542
87Arginine and proline metabolism_Homo sapiens_hsa003300.39648050
88Prion diseases_Homo sapiens_hsa050200.39214440
89Nitrogen metabolism_Homo sapiens_hsa009100.37435144
90Type I diabetes mellitus_Homo sapiens_hsa049400.37194171
91Non-small cell lung cancer_Homo sapiens_hsa052230.36236174
92Circadian rhythm_Homo sapiens_hsa047100.35937718
93Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.34862773
94Longevity regulating pathway - mammal_Homo sapiens_hsa042110.34798026
95Renal cell carcinoma_Homo sapiens_hsa052110.34099138
96SNARE interactions in vesicular transport_Homo sapiens_hsa041300.33581458
97Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.33060839
98Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.32276815
99Glycerophospholipid metabolism_Homo sapiens_hsa005640.32117521
100Wnt signaling pathway_Homo sapiens_hsa043100.31562118
101Central carbon metabolism in cancer_Homo sapiens_hsa052300.31523931
102Chemokine signaling pathway_Homo sapiens_hsa040620.31154322
103Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.30585053
104African trypanosomiasis_Homo sapiens_hsa051430.27909787
105Huntingtons disease_Homo sapiens_hsa050160.27899204
106Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.27454648
107Fatty acid biosynthesis_Homo sapiens_hsa000610.20637958
108Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.19346498
109Glycerolipid metabolism_Homo sapiens_hsa005610.18720081
110HIF-1 signaling pathway_Homo sapiens_hsa040660.17803705
111Arginine biosynthesis_Homo sapiens_hsa002200.17344871
112Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.15144235
113Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.15078636
114Mineral absorption_Homo sapiens_hsa049780.13995210
115AMPK signaling pathway_Homo sapiens_hsa041520.13293480

Most similar genes based on co-expression Upload to Enrichr

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