CLEC4A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may play a role in inflammatory and immune response. Multiple transcript variants encoding distinct isoforms have been identified for this gene. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neutrophil activation involved in immune response (GO:0002283)6.46463009
2immunoglobulin mediated immune response (GO:0016064)5.96619148
3response to peptidoglycan (GO:0032494)5.49873331
4positive regulation of mast cell activation (GO:0033005)5.20954862
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.10334570
6positive regulation by organism of defense response of other organism involved in symbiotic interact5.10334570
7modulation by symbiont of host immune response (GO:0052553)5.10334570
8positive regulation by symbiont of host defense response (GO:0052509)5.10334570
9modulation by symbiont of host defense response (GO:0052031)5.10334570
10modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.10334570
11positive regulation of gamma-delta T cell activation (GO:0046645)5.10119014
12positive regulation of mast cell activation involved in immune response (GO:0033008)5.05216429
13positive regulation of mast cell degranulation (GO:0043306)5.05216429
14detection of molecule of bacterial origin (GO:0032490)4.95652796
15macrophage activation involved in immune response (GO:0002281)4.81712272
16detection of other organism (GO:0098543)4.73620334
17negative regulation of interleukin-12 production (GO:0032695)4.69028192
18B cell mediated immunity (GO:0019724)4.68649124
19antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.61184184
20cellular extravasation (GO:0045123)4.49806192
21detection of external biotic stimulus (GO:0098581)4.49448962
22detection of bacterium (GO:0016045)4.48387104
23neutrophil activation (GO:0042119)4.43025139
24regulation of mast cell degranulation (GO:0043304)4.39053438
25negative regulation of cell killing (GO:0031342)4.31484081
26negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.31484081
27microglial cell activation (GO:0001774)4.30118118
28interferon-gamma-mediated signaling pathway (GO:0060333)4.28458159
29regulation of mast cell activation (GO:0033003)4.28365812
30granulocyte activation (GO:0036230)4.24265029
31positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.22469677
32regulation of B cell receptor signaling pathway (GO:0050855)4.21224784
33positive regulation of myeloid leukocyte mediated immunity (GO:0002888)4.17556837
34regulation of mast cell activation involved in immune response (GO:0033006)4.08990260
35myeloid cell activation involved in immune response (GO:0002275)4.06217280
36regulation of hypersensitivity (GO:0002883)4.04951674
37detection of biotic stimulus (GO:0009595)3.98654170
38positive regulation of leukocyte degranulation (GO:0043302)3.84100241
39macrophage activation (GO:0042116)3.80525379
40antigen processing and presentation of endogenous antigen (GO:0019883)3.77310821
41respiratory burst (GO:0045730)3.76683934
42regulation of myeloid leukocyte mediated immunity (GO:0002886)3.72097435
43regulation of gamma-delta T cell activation (GO:0046643)3.57905577
44regulation of T-helper 2 cell differentiation (GO:0045628)3.57588930
45lipopolysaccharide-mediated signaling pathway (GO:0031663)3.56967882
46positive regulation of type 2 immune response (GO:0002830)3.56128307
47regulation of leukocyte degranulation (GO:0043300)3.56038269
48response to host immune response (GO:0052572)3.54877077
49response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.54877077
50T-helper 1 type immune response (GO:0042088)3.49843320
51regulation of interferon-beta biosynthetic process (GO:0045357)3.49237830
52positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610813.42420508
53regulation of T cell tolerance induction (GO:0002664)3.40759410
54positive regulation of antigen processing and presentation (GO:0002579)3.40515451
55regulation of tolerance induction (GO:0002643)3.37481542
56cellular response to interferon-gamma (GO:0071346)3.33209357
57regulation of antigen processing and presentation (GO:0002577)3.32421906
58production of molecular mediator involved in inflammatory response (GO:0002532)3.31773243
59positive regulation of cellular amide metabolic process (GO:0034250)3.28316911
60positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.23062502
61neutrophil mediated immunity (GO:0002446)3.23002554
62leukocyte aggregation (GO:0070486)3.19035944
63regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.16418174
64positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.15941813
65defense response to protozoan (GO:0042832)3.15488154
66myeloid leukocyte activation (GO:0002274)3.13465129
67leukocyte migration involved in inflammatory response (GO:0002523)3.12939161
68antigen processing and presentation via MHC class Ib (GO:0002475)3.12453644
69response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.11884845
70response to host (GO:0075136)3.11884845
71response to host defenses (GO:0052200)3.11884845
72antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.10477262
73mast cell activation (GO:0045576)3.10174826
74response to interferon-gamma (GO:0034341)3.09947073
75response to muramyl dipeptide (GO:0032495)3.08784938
76regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.08421764
77neutrophil chemotaxis (GO:0030593)3.08333190
78positive regulation of regulated secretory pathway (GO:1903307)3.06882688
79positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.06855664
80regulation of dendritic cell antigen processing and presentation (GO:0002604)3.06807470
81regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.05635412
82negative regulation of lymphocyte mediated immunity (GO:0002707)3.05022149
83positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)3.03149009
84positive regulation of interleukin-1 beta secretion (GO:0050718)3.01559186
85neutrophil migration (GO:1990266)3.00797036
86negative regulation of T cell mediated immunity (GO:0002710)2.99784632
87positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.98911113
88regulation of regulated secretory pathway (GO:1903305)2.97984035
89leukocyte degranulation (GO:0043299)2.96303122
90negative regulation of myeloid cell apoptotic process (GO:0033033)2.95324153
91type I interferon signaling pathway (GO:0060337)2.95263076
92cellular response to type I interferon (GO:0071357)2.95263076
93regulation of type 2 immune response (GO:0002828)2.92809901
94response to protozoan (GO:0001562)2.91591222
95positive regulation of B cell differentiation (GO:0045579)2.90522798
96response to type I interferon (GO:0034340)2.89956808
97positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.89631302
98myeloid dendritic cell activation (GO:0001773)2.88956660
99adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli2.88897121
100granulocyte chemotaxis (GO:0071621)2.87578981

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.46216147
2BP1_19119308_ChIP-ChIP_Hs578T_Human6.35243431
3IRF8_21731497_ChIP-ChIP_J774_Mouse5.44057054
4IRF8_27001747_Chip-Seq_BMDM_Mouse4.05665791
5SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.71174810
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.59495067
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.52725610
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.35220977
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.28868808
10NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.18939183
11CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.02571564
12SPI1_23547873_ChIP-Seq_NB4_Human2.99131746
13MYB_21317192_ChIP-Seq_ERMYB_Mouse2.91122479
14IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.87180046
15SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.81257420
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.71722974
17Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.68823557
18SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.60823441
19NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.59175655
20SPI1_23127762_ChIP-Seq_K562_Human2.55940398
21STAT4_19710469_ChIP-ChIP_TH1__Mouse2.35140040
22SCL_19346495_ChIP-Seq_HPC-7_Human2.27164290
23RUNX_20019798_ChIP-Seq_JUKART_Human2.27067433
24VDR_24787735_ChIP-Seq_THP-1_Human2.26178546
25RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.20906988
26VDR_24763502_ChIP-Seq_THP-1_Human2.19607733
27MYB_26560356_Chip-Seq_TH2_Human2.09112050
28RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.98631315
29BRD4_27068464_Chip-Seq_AML-cells_Mouse1.98175286
30RUNX1_22412390_ChIP-Seq_EML_Mouse1.88899741
31FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.79737168
32LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.73956645
33LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.69190461
34CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.67302344
35MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.67118050
36E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.62322617
37PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.61998103
38VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.60713166
39* GATA3_27048872_Chip-Seq_THYMUS_Human1.59954881
40MYB_26560356_Chip-Seq_TH1_Human1.58416350
41MAF_26560356_Chip-Seq_TH1_Human1.57425608
42SMAD_19615063_ChIP-ChIP_OVARY_Human1.56583160
43VDR_21846776_ChIP-Seq_THP-1_Human1.56153991
44GATA3_26560356_Chip-Seq_TH2_Human1.54570017
45FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.51549789
46PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.51027584
47PU_27001747_Chip-Seq_BMDM_Mouse1.49069655
48SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.42974160
49CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.39800286
50EGR1_19374776_ChIP-ChIP_THP-1_Human1.33728114
51* UTX_26944678_Chip-Seq_JUKART_Human1.32775728
52CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.29432310
53STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.27760752
54ELF1_17652178_ChIP-ChIP_JURKAT_Human1.27026339
55CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.26268885
56GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.24665809
57PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.23929501
58IKZF1_21737484_ChIP-ChIP_HCT116_Human1.19586894
59SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.17562626
60GATA1_19941827_ChIP-Seq_MEL_Mouse1.13344799
61GATA2_22383799_ChIP-Seq_G1ME_Mouse1.12051686
62PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10355051
63NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.07049279
64STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.06964474
65VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.05799947
66MAF_26560356_Chip-Seq_TH2_Human1.02486553
67SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00359820
68SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.98409256
69GATA2_21666600_ChIP-Seq_HMVEC_Human0.97958487
70TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.97469257
71STAT1_20625510_ChIP-Seq_HELA_Human0.97161482
72ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.95941258
73RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.93196722
74GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92973872
75GATA1_22025678_ChIP-Seq_K562_Human0.91592774
76BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.89029823
77SMRT_27268052_Chip-Seq_Bcells_Human0.88880065
78SPI1_20517297_ChIP-Seq_HL60_Human0.87241624
79NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.86210782
80GATA1_22383799_ChIP-Seq_G1ME_Mouse0.83305486
81TCF7_22412390_ChIP-Seq_EML_Mouse0.82823088
82TFEB_21752829_ChIP-Seq_HELA_Human0.82681299
83EGR1_19032775_ChIP-ChIP_M12_Human0.76989220
84BCL6_27268052_Chip-Seq_Bcells_Human0.76917117
85PU.1_20513432_ChIP-Seq_Bcells_Mouse0.76831143
86KDM2B_26808549_Chip-Seq_SUP-B15_Human0.75574171
87MYC_22102868_ChIP-Seq_BL_Human0.71079163
88GATA1_19941826_ChIP-Seq_K562_Human0.70559290
89CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.69843736
90GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.69709316
91EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.68900321
92CIITA_25753668_ChIP-Seq_RAJI_Human0.68310594
93RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.67829588
94SALL4_22934838_ChIP-ChIP_CD34+_Human0.65627196
95GATA1_19941827_ChIP-Seq_MEL86_Mouse0.65310582
96CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.64747501
97GATA3_26560356_Chip-Seq_TH1_Human0.64624274
98GATA2_19941826_ChIP-Seq_K562_Human0.63589549
99RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.63565454
100FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.61985528

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.60088908
2MP0003724_increased_susceptibility_to4.39399489
3MP0003436_decreased_susceptibility_to3.75377292
4MP0005671_abnormal_response_to3.65481655
5MP0003303_peritoneal_inflammation3.44641536
6MP0009785_altered_susceptibility_to3.38636625
7MP0006082_CNS_inflammation3.30738177
8MP0002419_abnormal_innate_immunity3.27390835
9MP0002148_abnormal_hypersensitivity_rea3.13252610
10MP0005000_abnormal_immune_tolerance2.93989898
11MP0005025_abnormal_response_to2.89800232
12MP0001800_abnormal_humoral_immune2.81350638
13MP0005387_immune_system_phenotype2.70119122
14MP0001790_abnormal_immune_system2.70119122
15MP0002452_abnormal_antigen_presenting2.64247233
16MP0002723_abnormal_immune_serum2.57684687
17MP0000685_abnormal_immune_system2.41668473
18MP0002420_abnormal_adaptive_immunity2.33613217
19MP0001819_abnormal_immune_cell2.32807613
20MP0009764_decreased_sensitivity_to2.27693563
21MP0003172_abnormal_lysosome_physiology2.17615356
22MP0001533_abnormal_skeleton_physiology2.11248713
23MP0005058_abnormal_lysosome_morphology2.11198758
24MP0003191_abnormal_cellular_cholesterol2.09297830
25MP0003300_gastrointestinal_ulcer2.08894897
26MP0005464_abnormal_platelet_physiology2.08301187
27MP0003075_altered_response_to2.04855874
28MP0001845_abnormal_inflammatory_respons1.86895614
29MP0002405_respiratory_system_inflammati1.80368203
30MP0003828_pulmonary_edema1.72452058
31MP0010155_abnormal_intestine_physiology1.71364364
32MP0000343_altered_response_to1.67219961
33MP0000716_abnormal_immune_system1.67129282
34MP0008469_abnormal_protein_level1.64821816
35MP0001853_heart_inflammation1.64249380
36MP0008260_abnormal_autophagy1.59685945
37MP0003806_abnormal_nucleotide_metabolis1.59268118
38MP0000569_abnormal_digit_pigmentation1.59050879
39MP0005397_hematopoietic_system_phenotyp1.54531280
40MP0001545_abnormal_hematopoietic_system1.54531280
41MP0002398_abnormal_bone_marrow1.54125372
42MP0005451_abnormal_body_composition1.53782413
43MP0009278_abnormal_bone_marrow1.52980893
44MP0003183_abnormal_peptide_metabolism1.49377309
45MP0002998_abnormal_bone_remodeling1.47887563
46MP0000858_altered_metastatic_potential1.46884765
47MP0005166_decreased_susceptibility_to1.44858965
48MP0004947_skin_inflammation1.38336367
49MP0009333_abnormal_splenocyte_physiolog1.36008197
50MP0005310_abnormal_salivary_gland1.34147622
51MP0000689_abnormal_spleen_morphology1.31860614
52MP0002277_abnormal_respiratory_mucosa1.29988176
53MP0002429_abnormal_blood_cell1.28139505
54MP0004883_abnormal_blood_vessel1.24686761
55MP0000465_gastrointestinal_hemorrhage1.23515449
56MP0002722_abnormal_immune_system1.17660546
57MP0008004_abnormal_stomach_pH1.14689504
58MP0003448_altered_tumor_morphology1.14619725
59MP0003690_abnormal_glial_cell1.13838094
60MP0000604_amyloidosis1.13120146
61MP0005167_abnormal_blood-brain_barrier1.12221358
62MP0003866_abnormal_defecation1.09777820
63MP0009840_abnormal_foam_cell1.09638473
64MP0004510_myositis1.08888035
65MP0005164_abnormal_response_to1.06244774
66MP0002132_abnormal_respiratory_system1.05841525
67MP0003763_abnormal_thymus_physiology1.03159633
68MP0002166_altered_tumor_susceptibility1.02290858
69MP0009763_increased_sensitivity_to0.97892626
70MP0003656_abnormal_erythrocyte_physiolo0.93926888
71MP0000920_abnormal_myelination0.91170758
72MP0000015_abnormal_ear_pigmentation0.89706033
73MP0001851_eye_inflammation0.81999723
74MP0005390_skeleton_phenotype0.81577404
75MP0001986_abnormal_taste_sensitivity0.78157291
76MP0001663_abnormal_digestive_system0.77979265
77MP0006054_spinal_hemorrhage0.75917231
78MP0000249_abnormal_blood_vessel0.75867822
79MP0000703_abnormal_thymus_morphology0.75446812
80MP0003795_abnormal_bone_structure0.74051019
81MP0002332_abnormal_exercise_endurance0.74014955
82MP0005075_abnormal_melanosome_morpholog0.70205735
83MP0002396_abnormal_hematopoietic_system0.69238723
84MP0002006_tumorigenesis0.68862495
85MP0009765_abnormal_xenobiotic_induced0.67188396
86MP0004381_abnormal_hair_follicle0.64929613
87MP0001542_abnormal_bone_strength0.63298140
88MP0005174_abnormal_tail_pigmentation0.63017911
89MP0005319_abnormal_enzyme/_coenzyme0.62375414
90MP0001873_stomach_inflammation0.58727985
91MP0000371_diluted_coat_color0.58154435
92MP0008874_decreased_physiological_sensi0.54905731
93MP0005165_increased_susceptibility_to0.54183525
94MP0005367_renal/urinary_system_phenotyp0.53632345
95MP0000516_abnormal_urinary_system0.53632345
96MP0003195_calcinosis0.53287563
97MP0005647_abnormal_sex_gland0.51393634
98MP0003045_fibrosis0.51068608
99MP0005584_abnormal_enzyme/coenzyme_acti0.46705390
100MP0002933_joint_inflammation0.46676686

Predicted human phenotypes

RankGene SetZ-score
1Recurrent bacterial skin infections (HP:0005406)6.37328464
2Recurrent abscess formation (HP:0002722)6.21276879
3Abnormality of macrophages (HP:0004311)5.67716060
4Eczematoid dermatitis (HP:0000976)5.55207381
5Recurrent gram-negative bacterial infections (HP:0005420)4.93043757
6Myositis (HP:0100614)4.79558792
7Orchitis (HP:0100796)4.57508395
8Retrobulbar optic neuritis (HP:0100654)4.53283273
9Optic neuritis (HP:0100653)4.53283273
10Obstructive lung disease (HP:0006536)4.38481672
11Chronic obstructive pulmonary disease (HP:0006510)4.38481672
12Abnormality of glycosphingolipid metabolism (HP:0004343)4.31978672
13Abnormality of glycolipid metabolism (HP:0010969)4.31978672
14Abnormality of liposaccharide metabolism (HP:0010968)4.31978672
15Stomatitis (HP:0010280)4.26354668
16Mediastinal lymphadenopathy (HP:0100721)4.23318130
17Recurrent skin infections (HP:0001581)4.16487599
18Elevated erythrocyte sedimentation rate (HP:0003565)3.96426998
19Recurrent fungal infections (HP:0002841)3.95772636
20Chronic mucocutaneous candidiasis (HP:0002728)3.78784036
21Recurrent cutaneous fungal infections (HP:0011370)3.78784036
22Meningitis (HP:0001287)3.77903085
23Hemoptysis (HP:0002105)3.62341613
24Increased cerebral lipofuscin (HP:0011813)3.50642374
25Gastrointestinal infarctions (HP:0005244)3.50530015
26Pulmonary infiltrates (HP:0002113)3.47425015
27Urticaria (HP:0001025)3.45472101
28Vasculitis (HP:0002633)3.43043319
29Systemic lupus erythematosus (HP:0002725)3.39702913
30Spontaneous hematomas (HP:0007420)3.39088396
31Amyloidosis (HP:0011034)3.37671902
32Vacuolated lymphocytes (HP:0001922)3.37122578
33Chest pain (HP:0100749)3.21226422
34Keratoconjunctivitis sicca (HP:0001097)3.19052903
35Disinhibition (HP:0000734)3.17719507
36Gingivitis (HP:0000230)3.12032052
37Increased neuronal autofluorescent lipopigment (HP:0002074)3.09050580
38Keratoconjunctivitis (HP:0001096)3.01200000
39Encephalitis (HP:0002383)2.95073050
40Abnormal delayed hypersensitivity skin test (HP:0002963)2.88430954
41Loss of speech (HP:0002371)2.85135192
42Gingival bleeding (HP:0000225)2.81470178
43Dysostosis multiplex (HP:0000943)2.81106430
44Gangrene (HP:0100758)2.78106530
45T lymphocytopenia (HP:0005403)2.74160441
46Arterial thrombosis (HP:0004420)2.73829194
47Pulmonary embolism (HP:0002204)2.73028825
48Petechiae (HP:0000967)2.70462220
49Abnormality of the pleura (HP:0002103)2.70135533
50Epistaxis (HP:0000421)2.69751314
51Abnormality of T cell number (HP:0011839)2.68590590
52Leukocytosis (HP:0001974)2.46434595
53Recurrent viral infections (HP:0004429)2.45969228
54Mutism (HP:0002300)2.44229421
55Abnormality of the prostate (HP:0008775)2.44229307
56Autoimmune thrombocytopenia (HP:0001973)2.43862022
57Polyneuropathy (HP:0001271)2.41992703
58Anorexia (HP:0002039)2.41574837
59Purpura (HP:0000979)2.38789539
60Increased IgM level (HP:0003496)2.34558940
61Episodic fever (HP:0001954)2.34196544
62Abnormality of polysaccharide metabolism (HP:0011012)2.34174853
63Abnormality of glycosaminoglycan metabolism (HP:0004371)2.34174853
64Abnormality of mucopolysaccharide metabolism (HP:0011020)2.34174853
65Pustule (HP:0200039)2.34114386
66Prolonged bleeding time (HP:0003010)2.32257793
67Increased serum ferritin (HP:0003281)2.29623262
68Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.28878165
69Osteomyelitis (HP:0002754)2.22919182
70Basal ganglia calcification (HP:0002135)2.21524628
71Cellulitis (HP:0100658)2.19110664
72Premature loss of primary teeth (HP:0006323)2.17532668
73Peritonitis (HP:0002586)2.16783657
74Glomerulopathy (HP:0100820)2.16099216
75Urinary glycosaminoglycan excretion (HP:0003541)2.14233895
76Mucopolysacchariduria (HP:0008155)2.14233895
77Vertigo (HP:0002321)2.13508884
78Inflammation of the large intestine (HP:0002037)2.12521967
79Abnormality of the peritoneum (HP:0002585)2.12494391
80Increased IgE level (HP:0003212)2.11752102
81Amaurosis fugax (HP:0100576)2.10503429
82Abnormality of iron homeostasis (HP:0011031)2.09241072
83Memory impairment (HP:0002354)2.07222364
84Thrombophlebitis (HP:0004418)2.06946451
85Hepatosplenomegaly (HP:0001433)2.06625404
86Abnormality of T cells (HP:0002843)2.04050675
87Agnosia (HP:0010524)2.02165219
88Recurrent pneumonia (HP:0006532)1.98537078
89Panhypogammaglobulinemia (HP:0003139)1.97645498
90Cheilitis (HP:0100825)1.97129834
91Xerostomia (HP:0000217)1.95270085
92Gastrointestinal inflammation (HP:0004386)1.95067174
93Progressive neurologic deterioration (HP:0002344)1.94425951
94Keratitis (HP:0000491)1.92191250
95Skin rash (HP:0000988)1.90678153
96Myocardial infarction (HP:0001658)1.86962808
97Skin ulcer (HP:0200042)1.86682925
98Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.86112411
99Abnormality of the endocardium (HP:0004306)1.85339405
100Abnormality of the pericardium (HP:0001697)1.84683706

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.87112977
2BLK4.18500733
3BMPR23.52111470
4TYK23.13994214
5MAP4K12.82712309
6CSK2.67122879
7IRAK42.57813403
8MAP2K32.39151387
9CSF1R2.39122777
10FES2.34774109
11TXK2.33818347
12FGR2.12278174
13JAK32.06482996
14MAP3K142.01859664
15CDK191.99386518
16ZAP701.95747514
17SYK1.89608668
18LYN1.78534865
19PIK3CG1.76879855
20KIT1.72993235
21MAP3K31.67478827
22GRK71.65777552
23TAOK31.62296029
24BTK1.62142493
25MATK1.61872151
26IKBKB1.57443536
27GRK61.56813172
28TNK21.56627817
29HCK1.56085523
30TGFBR21.52141054
31MAP3K131.45547397
32IKBKE1.42779674
33JAK21.42119940
34TBK11.41333720
35MAP3K121.38365739
36JAK11.36653594
37ERN11.30999138
38LCK1.20524798
39TAOK11.15445516
40TEC1.14711876
41IRAK11.09403005
42YES11.07397943
43MAP3K111.04860526
44ITK1.04458708
45IRAK21.04401632
46SIK30.94465763
47MARK30.92803809
48CAMKK20.89381838
49MAP3K10.88500885
50MAP3K20.85060641
51MOS0.83975314
52PDK10.81252981
53TAOK20.77522651
54IRAK30.76384345
55PRPF4B0.76169869
56EPHB10.72170384
57KSR20.66680815
58PDPK10.64945793
59MAP3K50.64888698
60ACVR1B0.61389781
61ADRBK20.59627422
62DAPK20.58126565
63FYN0.58104073
64TESK20.57710410
65EGFR0.54480235
66OXSR10.51498106
67CDC42BPA0.50312551
68ABL10.50160346
69MAP2K60.49653906
70TRPM70.49207446
71MAP3K60.47185944
72PRKCQ0.46144869
73MAPK120.41596961
74PTK2B0.41264976
75MAPK70.41118130
76STK100.40845635
77PIM10.38808329
78IGF1R0.38711043
79PRKCD0.37881991
80MAP2K40.37207973
81MARK20.36636342
82RPS6KC10.32028654
83RPS6KL10.32028654
84SGK30.31362836
85NME20.31264626
86DYRK30.31159385
87DYRK1B0.30646588
88CHUK0.30205959
89ARAF0.29920486
90RPS6KA60.29470079
91SIK20.27851894
92ABL20.27769871
93STK110.26841213
94SGK20.25374637
95RAF10.24775635
96FRK0.24516823
97ILK0.23038464
98CAMKK10.22252243
99KSR10.21297018
100PRKG20.21052117

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053104.36078950
2Allograft rejection_Homo sapiens_hsa053303.98726206
3Graft-versus-host disease_Homo sapiens_hsa053323.86939767
4Staphylococcus aureus infection_Homo sapiens_hsa051503.86786378
5Autoimmune thyroid disease_Homo sapiens_hsa053203.70420885
6Leishmaniasis_Homo sapiens_hsa051403.40769518
7Type I diabetes mellitus_Homo sapiens_hsa049403.17299548
8Intestinal immune network for IgA production_Homo sapiens_hsa046723.09624835
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.70479680
10Rheumatoid arthritis_Homo sapiens_hsa053232.56800950
11Tuberculosis_Homo sapiens_hsa051522.45740556
12Antigen processing and presentation_Homo sapiens_hsa046122.40947457
13Osteoclast differentiation_Homo sapiens_hsa043802.37856489
14Viral myocarditis_Homo sapiens_hsa054162.37679251
15Hematopoietic cell lineage_Homo sapiens_hsa046401.96550789
16Toll-like receptor signaling pathway_Homo sapiens_hsa046201.94900036
17NOD-like receptor signaling pathway_Homo sapiens_hsa046211.91722948
18Phagosome_Homo sapiens_hsa041451.84671503
19Legionellosis_Homo sapiens_hsa051341.74442947
20Toxoplasmosis_Homo sapiens_hsa051451.72337211
21Influenza A_Homo sapiens_hsa051641.60102553
22Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.46262514
23Lysosome_Homo sapiens_hsa041421.45717054
24Malaria_Homo sapiens_hsa051441.39932681
25Pertussis_Homo sapiens_hsa051331.39472088
26Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.38003151
27NF-kappa B signaling pathway_Homo sapiens_hsa040641.37172915
28B cell receptor signaling pathway_Homo sapiens_hsa046621.35884540
29Other glycan degradation_Homo sapiens_hsa005111.31295787
30Herpes simplex infection_Homo sapiens_hsa051681.28360410
31Salmonella infection_Homo sapiens_hsa051321.26383626
32Chemokine signaling pathway_Homo sapiens_hsa040621.25032119
33Primary immunodeficiency_Homo sapiens_hsa053401.19855895
34Measles_Homo sapiens_hsa051621.12161450
35Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.06593885
36TNF signaling pathway_Homo sapiens_hsa046681.05150324
37Glycosaminoglycan degradation_Homo sapiens_hsa005311.02432057
38African trypanosomiasis_Homo sapiens_hsa051430.98535351
39Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.98111387
40Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.96650660
41Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.96445424
42Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.93365608
43Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.91647101
44SNARE interactions in vesicular transport_Homo sapiens_hsa041300.90612342
45T cell receptor signaling pathway_Homo sapiens_hsa046600.88374910
46RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.86204414
47Jak-STAT signaling pathway_Homo sapiens_hsa046300.85764049
48Collecting duct acid secretion_Homo sapiens_hsa049660.84346987
49Shigellosis_Homo sapiens_hsa051310.81319785
50Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.79962967
51Platelet activation_Homo sapiens_hsa046110.78081293
52Leukocyte transendothelial migration_Homo sapiens_hsa046700.65853322
53Systemic lupus erythematosus_Homo sapiens_hsa053220.65807751
54Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.61827950
55Hepatitis B_Homo sapiens_hsa051610.59844154
56Epstein-Barr virus infection_Homo sapiens_hsa051690.57937436
57Acute myeloid leukemia_Homo sapiens_hsa052210.57780737
58Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.52784340
59Sphingolipid signaling pathway_Homo sapiens_hsa040710.50101517
60Hepatitis C_Homo sapiens_hsa051600.49744407
61Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48491867
62Apoptosis_Homo sapiens_hsa042100.48251997
63Complement and coagulation cascades_Homo sapiens_hsa046100.41686199
64Amoebiasis_Homo sapiens_hsa051460.37865378
65Regulation of autophagy_Homo sapiens_hsa041400.37317655
66Endocytosis_Homo sapiens_hsa041440.36843120
67Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.32756604
68Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.32211770
69HTLV-I infection_Homo sapiens_hsa051660.31227763
70Non-small cell lung cancer_Homo sapiens_hsa052230.28761069
71Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.26314000
72Prolactin signaling pathway_Homo sapiens_hsa049170.25969214
73Neurotrophin signaling pathway_Homo sapiens_hsa047220.25250437
74Bladder cancer_Homo sapiens_hsa052190.24800871
75Transcriptional misregulation in cancer_Homo sapiens_hsa052020.23707570
76AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.23201915
77VEGF signaling pathway_Homo sapiens_hsa043700.22118530
78Arachidonic acid metabolism_Homo sapiens_hsa005900.20993383
79HIF-1 signaling pathway_Homo sapiens_hsa040660.19453185
80Phospholipase D signaling pathway_Homo sapiens_hsa040720.19432400
81Carbohydrate digestion and absorption_Homo sapiens_hsa049730.19212625
82Renal cell carcinoma_Homo sapiens_hsa052110.18150800
83Vibrio cholerae infection_Homo sapiens_hsa051100.17845610
84Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.16529211
85Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.15412587
86Adipocytokine signaling pathway_Homo sapiens_hsa049200.14392481
87Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.13711196
88Pancreatic cancer_Homo sapiens_hsa052120.12694717
89Mineral absorption_Homo sapiens_hsa049780.12423277
90Sphingolipid metabolism_Homo sapiens_hsa006000.11859611
91GnRH signaling pathway_Homo sapiens_hsa049120.11818763
92Viral carcinogenesis_Homo sapiens_hsa052030.09045183
93Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.08859031
94Type II diabetes mellitus_Homo sapiens_hsa049300.08821805
95MAPK signaling pathway_Homo sapiens_hsa040100.06981113
96Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.05939059
97FoxO signaling pathway_Homo sapiens_hsa040680.05510839
98Regulation of actin cytoskeleton_Homo sapiens_hsa048100.04925238
99Dorso-ventral axis formation_Homo sapiens_hsa043200.04503603
100Ether lipid metabolism_Homo sapiens_hsa005650.04307369

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »