CLEC4C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may play a role in dendritic cell function. Two transcript variants encoding distinct isoforms have been identified for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)5.69048912
2fucose catabolic process (GO:0019317)4.64771234
3L-fucose metabolic process (GO:0042354)4.64771234
4L-fucose catabolic process (GO:0042355)4.64771234
5DNA methylation involved in gamete generation (GO:0043046)4.23194169
6response to pheromone (GO:0019236)4.17865560
7DNA deamination (GO:0045006)4.01129276
8epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.97584891
9negative regulation of cAMP-mediated signaling (GO:0043951)3.79746214
10behavioral response to nicotine (GO:0035095)3.70885538
11organelle disassembly (GO:1903008)3.70592105
12regulation of cilium movement (GO:0003352)3.69678222
13negative regulation of cytosolic calcium ion concentration (GO:0051481)3.67897381
14regulation of meiosis I (GO:0060631)3.65132161
15ribonucleoprotein complex disassembly (GO:0032988)3.61324947
16detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.42895882
17purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)3.30644378
18protein polyglutamylation (GO:0018095)3.30480998
19negative regulation of telomere maintenance (GO:0032205)3.27473520
20platelet dense granule organization (GO:0060155)3.24803165
21ubiquinone biosynthetic process (GO:0006744)3.23455845
22epithelial cilium movement (GO:0003351)3.21191321
23regulation of acrosome reaction (GO:0060046)3.20473410
24indolalkylamine metabolic process (GO:0006586)3.09839073
25neural tube formation (GO:0001841)3.02273020
26RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.01656756
27L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.99544692
28multicellular organism reproduction (GO:0032504)2.98961781
29ubiquinone metabolic process (GO:0006743)2.96606500
30respiratory chain complex IV assembly (GO:0008535)2.95529003
31retinal cone cell development (GO:0046549)2.95527972
32photoreceptor cell maintenance (GO:0045494)2.90844133
33male meiosis (GO:0007140)2.90110208
34kynurenine metabolic process (GO:0070189)2.90051578
35RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.88307027
36tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.88307027
37glycosphingolipid biosynthetic process (GO:0006688)2.87959494
38axoneme assembly (GO:0035082)2.80420851
39detection of light stimulus involved in visual perception (GO:0050908)2.77909610
40detection of light stimulus involved in sensory perception (GO:0050962)2.77909610
41male meiosis I (GO:0007141)2.76243384
42immunoglobulin mediated immune response (GO:0016064)2.75227251
43protein K11-linked deubiquitination (GO:0035871)2.74812473
44L-methionine salvage (GO:0071267)2.73853673
45L-methionine biosynthetic process (GO:0071265)2.73853673
46amino acid salvage (GO:0043102)2.73853673
47protein-cofactor linkage (GO:0018065)2.70738636
48regulation of protein glycosylation (GO:0060049)2.70685097
49phosphatidylinositol acyl-chain remodeling (GO:0036149)2.66663889
50purine deoxyribonucleotide catabolic process (GO:0009155)2.66439293
51cilium morphogenesis (GO:0060271)2.65433878
52regulation of microtubule-based movement (GO:0060632)2.63982935
53cytidine metabolic process (GO:0046087)2.63361535
54cytidine catabolic process (GO:0006216)2.63361535
55cytidine deamination (GO:0009972)2.63361535
56positive regulation of prostaglandin secretion (GO:0032308)2.62604308
57indole-containing compound catabolic process (GO:0042436)2.62245497
58indolalkylamine catabolic process (GO:0046218)2.62245497
59tryptophan catabolic process (GO:0006569)2.62245497
60quinone biosynthetic process (GO:1901663)2.61267282
61cytochrome complex assembly (GO:0017004)2.60841549
62preassembly of GPI anchor in ER membrane (GO:0016254)2.59377398
63protein localization to cilium (GO:0061512)2.59178573
64regulation of B cell apoptotic process (GO:0002902)2.55263705
65opioid receptor signaling pathway (GO:0038003)2.54974612
66protein complex biogenesis (GO:0070271)2.54321897
67deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.53732278
68tryptophan metabolic process (GO:0006568)2.53450541
69adenosine metabolic process (GO:0046085)2.53440977
70ncRNA catabolic process (GO:0034661)2.52933388
71adaptation of signaling pathway (GO:0023058)2.52513146
72amine catabolic process (GO:0009310)2.51892985
73cellular biogenic amine catabolic process (GO:0042402)2.51892985
74negative regulation of B cell apoptotic process (GO:0002903)2.51625587
75regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.51364591
76mitochondrial respiratory chain complex I assembly (GO:0032981)2.50565689
77NADH dehydrogenase complex assembly (GO:0010257)2.50565689
78mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.50565689
79B cell mediated immunity (GO:0019724)2.50549466
80nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.49208999
81water-soluble vitamin biosynthetic process (GO:0042364)2.46261440
82behavioral response to ethanol (GO:0048149)2.44683061
83regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.44348910
84mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.42728512
85positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.42728512
86negative regulation of mast cell activation (GO:0033004)2.41361450
87pseudouridine synthesis (GO:0001522)2.40021296
88negative regulation of reactive oxygen species metabolic process (GO:2000378)2.38703018
89histone H3-K4 trimethylation (GO:0080182)2.37527825
90methionine biosynthetic process (GO:0009086)2.37234811
91gene silencing by RNA (GO:0031047)2.36697138
92positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.36324574
93mannosylation (GO:0097502)2.36091080
94interferon-gamma production (GO:0032609)2.35902935
95positive regulation of cAMP-mediated signaling (GO:0043950)2.35045780
96positive regulation of granulocyte differentiation (GO:0030854)2.34327612
97meiotic cell cycle (GO:0051321)2.34156879
98cilium movement (GO:0003341)2.33992176
99regulation of female gonad development (GO:2000194)2.33157500
100positive regulation of fatty acid transport (GO:2000193)2.32314715

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.58890067
2VDR_22108803_ChIP-Seq_LS180_Human3.12697595
3BP1_19119308_ChIP-ChIP_Hs578T_Human2.70076319
4IRF8_22096565_ChIP-ChIP_GC-B_Human2.62744007
5IGF1R_20145208_ChIP-Seq_DFB_Human2.56093166
6GBX2_23144817_ChIP-Seq_PC3_Human2.55171541
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.49345947
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.47521560
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.42991159
10BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.37761491
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.25910246
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.19009147
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.12132683
14MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.09870246
15EZH2_22144423_ChIP-Seq_EOC_Human2.08187877
16ZFP57_27257070_Chip-Seq_ESCs_Mouse2.03692720
17POU3F2_20337985_ChIP-ChIP_501MEL_Human2.01661340
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.98883219
19P300_19829295_ChIP-Seq_ESCs_Human1.85545433
20CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.84490463
21PCGF2_27294783_Chip-Seq_ESCs_Mouse1.79529423
22IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.75188067
23CBP_20019798_ChIP-Seq_JUKART_Human1.75188067
24EWS_26573619_Chip-Seq_HEK293_Human1.74392862
25EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.71904208
26FUS_26573619_Chip-Seq_HEK293_Human1.67811056
27NOTCH1_21737748_ChIP-Seq_TLL_Human1.66824954
28TP53_22573176_ChIP-Seq_HFKS_Human1.65760686
29ER_23166858_ChIP-Seq_MCF-7_Human1.64136548
30IRF1_19129219_ChIP-ChIP_H3396_Human1.63038935
31TAF15_26573619_Chip-Seq_HEK293_Human1.62793557
32VDR_23849224_ChIP-Seq_CD4+_Human1.58074453
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.55822439
34EST1_17652178_ChIP-ChIP_JURKAT_Human1.55730835
35* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.55430553
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.54522354
37AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.54515991
38ELK1_19687146_ChIP-ChIP_HELA_Human1.51521518
39PCGF2_27294783_Chip-Seq_NPCs_Mouse1.51151012
40CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.46524945
41MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.46148948
42* NANOG_19829295_ChIP-Seq_ESCs_Human1.45385660
43* SOX2_19829295_ChIP-Seq_ESCs_Human1.45385660
44BCAT_22108803_ChIP-Seq_LS180_Human1.44037710
45POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.43995359
46TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43995359
47IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.39635680
48GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.38727475
49NFE2_27457419_Chip-Seq_LIVER_Mouse1.38580658
50EZH2_27294783_Chip-Seq_NPCs_Mouse1.37036796
51STAT3_23295773_ChIP-Seq_U87_Human1.35402555
52SUZ12_27294783_Chip-Seq_NPCs_Mouse1.34090607
53MYC_18940864_ChIP-ChIP_HL60_Human1.33298821
54AR_25329375_ChIP-Seq_VCAP_Human1.33068938
55TCF4_23295773_ChIP-Seq_U87_Human1.31865200
56FOXP3_21729870_ChIP-Seq_TREG_Human1.31705939
57SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.31585465
58RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.29914546
59SMAD4_21799915_ChIP-Seq_A2780_Human1.25590092
60GATA3_21878914_ChIP-Seq_MCF-7_Human1.25266615
61KLF5_20875108_ChIP-Seq_MESCs_Mouse1.23912567
62PRDM14_20953172_ChIP-Seq_ESCs_Human1.22351770
63AR_20517297_ChIP-Seq_VCAP_Human1.21947669
64SALL1_21062744_ChIP-ChIP_HESCs_Human1.21604622
65GATA3_26560356_Chip-Seq_TH2_Human1.21302022
66CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.20520991
67FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.20003413
68CDX2_22108803_ChIP-Seq_LS180_Human1.18817718
69TCF4_22108803_ChIP-Seq_LS180_Human1.16932593
70MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.16419793
71EGR1_23403033_ChIP-Seq_LIVER_Mouse1.16143679
72IRF8_21731497_ChIP-ChIP_J774_Mouse1.15680195
73NCOR_22424771_ChIP-Seq_293T_Human1.13275642
74FLI1_21867929_ChIP-Seq_TH2_Mouse1.13081717
75HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.12825407
76PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.11938344
77NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.11083716
78HOXB7_26014856_ChIP-Seq_BT474_Human1.10726579
79FOXA1_25329375_ChIP-Seq_VCAP_Human1.10557880
80FOXA1_27270436_Chip-Seq_PROSTATE_Human1.10557880
81TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.09994762
82CRX_20693478_ChIP-Seq_RETINA_Mouse1.09455136
83STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.08974118
84CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.08563787
85TOP2B_26459242_ChIP-Seq_MCF-7_Human1.05681463
86FOXA1_21572438_ChIP-Seq_LNCaP_Human1.05513302
87RUNX2_22187159_ChIP-Seq_PCA_Human1.04822227
88EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.04804865
89PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04574429
90NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04421386
91SRF_21415370_ChIP-Seq_HL-1_Mouse1.04389461
92GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.03633988
93SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02556077
94SMRT_27268052_Chip-Seq_Bcells_Human1.02012968
95* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.01610636
96AUTS2_25519132_ChIP-Seq_293T-REX_Human1.00769565
97STAT3_18555785_Chip-Seq_ESCs_Mouse0.99101207
98PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.98707540
99SALL4_22934838_ChIP-ChIP_CD34+_Human0.98357024
100CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.97500780

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.59947614
2MP0002102_abnormal_ear_morphology3.52498804
3MP0003195_calcinosis2.84880170
4MP0000372_irregular_coat_pigmentation2.79363109
5MP0002138_abnormal_hepatobiliary_system2.58955850
6MP0003787_abnormal_imprinting2.52763741
7MP0003646_muscle_fatigue2.48552355
8MP0005551_abnormal_eye_electrophysiolog2.39720920
9MP0001835_abnormal_antigen_presentation2.38578878
10MP0001968_abnormal_touch/_nociception2.38547310
11MP0001986_abnormal_taste_sensitivity2.13741851
12MP0002876_abnormal_thyroid_physiology2.06568264
13MP0000569_abnormal_digit_pigmentation2.05922461
14MP0003718_maternal_effect1.99066473
15MP0001984_abnormal_olfaction1.97175313
16MP0006292_abnormal_olfactory_placode1.97166511
17MP0003950_abnormal_plasma_membrane1.93985680
18MP0005075_abnormal_melanosome_morpholog1.86016476
19MP0005645_abnormal_hypothalamus_physiol1.85279146
20MP0002638_abnormal_pupillary_reflex1.79924359
21MP0008872_abnormal_physiological_respon1.79022751
22MP0008875_abnormal_xenobiotic_pharmacok1.76080955
23MP0008789_abnormal_olfactory_epithelium1.75173582
24MP0000427_abnormal_hair_cycle1.74144010
25MP0003724_increased_susceptibility_to1.71318775
26MP0003252_abnormal_bile_duct1.66817865
27MP0006276_abnormal_autonomic_nervous1.66677827
28MP0004142_abnormal_muscle_tone1.65254169
29MP0005084_abnormal_gallbladder_morpholo1.62514658
30MP0005253_abnormal_eye_physiology1.58407025
31MP0003880_abnormal_central_pattern1.52022524
32MP0008058_abnormal_DNA_repair1.49867768
33MP0005377_hearing/vestibular/ear_phenot1.45802300
34MP0003878_abnormal_ear_physiology1.45802300
35MP0006072_abnormal_retinal_apoptosis1.43037578
36MP0009764_decreased_sensitivity_to1.41280338
37MP0002928_abnormal_bile_duct1.36435609
38MP0002272_abnormal_nervous_system1.35130713
39MP0005499_abnormal_olfactory_system1.31675056
40MP0005394_taste/olfaction_phenotype1.31675056
41MP0001501_abnormal_sleep_pattern1.31664862
42MP0002095_abnormal_skin_pigmentation1.27974888
43MP0005171_absent_coat_pigmentation1.24969924
44MP0009046_muscle_twitch1.24666827
45MP0001529_abnormal_vocalization1.23979365
46MP0005671_abnormal_response_to1.23092267
47MP0000015_abnormal_ear_pigmentation1.22924448
48MP0002148_abnormal_hypersensitivity_rea1.22418125
49MP0001486_abnormal_startle_reflex1.20906704
50MP0009745_abnormal_behavioral_response1.19762941
51MP0005410_abnormal_fertilization1.16197054
52MP0009785_altered_susceptibility_to1.15994405
53MP0004043_abnormal_pH_regulation1.15759065
54MP0005174_abnormal_tail_pigmentation1.13796695
55MP0003806_abnormal_nucleotide_metabolis1.13408908
56MP0002736_abnormal_nociception_after1.12297780
57MP0006054_spinal_hemorrhage1.09387994
58MP0001764_abnormal_homeostasis1.09071386
59MP0002653_abnormal_ependyma_morphology1.08120414
60MP0003786_premature_aging1.07963435
61MP0005646_abnormal_pituitary_gland1.07141800
62MP0004147_increased_porphyrin_level1.04987521
63MP0003121_genomic_imprinting1.03546838
64MP0001800_abnormal_humoral_immune1.01717457
65MP0004484_altered_response_of1.01573885
66MP0004885_abnormal_endolymph1.00975878
67MP0001929_abnormal_gametogenesis0.97216349
68MP0002837_dystrophic_cardiac_calcinosis0.95146574
69MP0006036_abnormal_mitochondrial_physio0.94997213
70MP0006035_abnormal_mitochondrial_morpho0.93904711
71MP0010386_abnormal_urinary_bladder0.92299029
72MP0005310_abnormal_salivary_gland0.92022287
73MP0008995_early_reproductive_senescence0.89632793
74MP0001485_abnormal_pinna_reflex0.89448948
75MP0000631_abnormal_neuroendocrine_gland0.87535580
76MP0000685_abnormal_immune_system0.86321645
77MP0001970_abnormal_pain_threshold0.86088238
78MP0002733_abnormal_thermal_nociception0.85928896
79MP0000383_abnormal_hair_follicle0.83182582
80MP0005389_reproductive_system_phenotype0.82356927
81MP0001324_abnormal_eye_pigmentation0.81280782
82MP0002723_abnormal_immune_serum0.81118257
83MP0002938_white_spotting0.79652887
84MP0002452_abnormal_antigen_presenting0.77574448
85MP0002163_abnormal_gland_morphology0.77359189
86MP0003136_yellow_coat_color0.76661209
87MP0005167_abnormal_blood-brain_barrier0.76612255
88MP0002909_abnormal_adrenal_gland0.76329346
89MP0004924_abnormal_behavior0.75462097
90MP0005386_behavior/neurological_phenoty0.75462097
91MP0002751_abnormal_autonomic_nervous0.75441353
92MP0006082_CNS_inflammation0.74966750
93MP0003698_abnormal_male_reproductive0.73075820
94MP0000647_abnormal_sebaceous_gland0.72922968
95MP0002210_abnormal_sex_determination0.71303434
96MP0002090_abnormal_vision0.70292867
97MP0005195_abnormal_posterior_eye0.70105368
98MP0008775_abnormal_heart_ventricle0.70100332
99MP0002420_abnormal_adaptive_immunity0.67947545
100MP0003183_abnormal_peptide_metabolism0.67422048

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.59162031
2Pancreatic fibrosis (HP:0100732)4.00020670
3Molar tooth sign on MRI (HP:0002419)3.70177387
4Abnormality of midbrain morphology (HP:0002418)3.70177387
5True hermaphroditism (HP:0010459)3.54439395
6Congenital stationary night blindness (HP:0007642)3.38343656
7Abnormality of the renal cortex (HP:0011035)3.22477233
8Type II lissencephaly (HP:0007260)3.06613786
9Bile duct proliferation (HP:0001408)3.04682510
10Abnormal biliary tract physiology (HP:0012439)3.04682510
11Abolished electroretinogram (ERG) (HP:0000550)2.90395571
12Cystic liver disease (HP:0006706)2.89611506
13Medial flaring of the eyebrow (HP:0010747)2.87101441
14Nephronophthisis (HP:0000090)2.86004050
15Tubular atrophy (HP:0000092)2.83159761
16Attenuation of retinal blood vessels (HP:0007843)2.76812582
17Stomatitis (HP:0010280)2.75285389
18Abnormality of the renal medulla (HP:0100957)2.75171236
19Abnormal rod and cone electroretinograms (HP:0008323)2.71502013
20Polydipsia (HP:0001959)2.67975528
21Abnormal drinking behavior (HP:0030082)2.67975528
22Pendular nystagmus (HP:0012043)2.60802060
23Hypothermia (HP:0002045)2.57748872
24Renal cortical cysts (HP:0000803)2.52717790
25Increased corneal curvature (HP:0100692)2.51656681
26Keratoconus (HP:0000563)2.51656681
27Hyperventilation (HP:0002883)2.48560640
28Decreased central vision (HP:0007663)2.47843044
29Stomach cancer (HP:0012126)2.43575876
30Hypoproteinemia (HP:0003075)2.41004982
31Lissencephaly (HP:0001339)2.36161325
32Absent rod-and cone-mediated responses on ERG (HP:0007688)2.31837700
33Polyuria (HP:0000103)2.30937758
34Increased CSF lactate (HP:0002490)2.26627817
35Chronic hepatic failure (HP:0100626)2.26278521
36Acute necrotizing encephalopathy (HP:0006965)2.25971937
37Aplasia/Hypoplasia of the tongue (HP:0010295)2.25337685
38Thyroid-stimulating hormone excess (HP:0002925)2.25136403
39Congenital hepatic fibrosis (HP:0002612)2.25117807
40Congenital primary aphakia (HP:0007707)2.24399300
41Gait imbalance (HP:0002141)2.20814497
42Mitochondrial inheritance (HP:0001427)2.19260928
43Nephrogenic diabetes insipidus (HP:0009806)2.18398755
44Progressive inability to walk (HP:0002505)2.16615110
453-Methylglutaconic aciduria (HP:0003535)2.13289916
46Sclerocornea (HP:0000647)2.11913365
47Absent speech (HP:0001344)2.11504710
48Decreased circulating renin level (HP:0003351)2.10809168
49Fair hair (HP:0002286)2.10682647
50Gaze-evoked nystagmus (HP:0000640)2.08005158
51Progressive macrocephaly (HP:0004481)2.07279050
52Anencephaly (HP:0002323)2.05176278
53Cerebellar dysplasia (HP:0007033)2.00327441
54Neonatal respiratory distress (HP:0002643)1.96114616
55Pachygyria (HP:0001302)1.95391809
56Acute encephalopathy (HP:0006846)1.93713057
57Macular degeneration (HP:0000608)1.92610088
58Decreased electroretinogram (ERG) amplitude (HP:0000654)1.90716936
59Optic disc pallor (HP:0000543)1.90690949
60Abnormality of the pons (HP:0007361)1.90602736
61Prostate neoplasm (HP:0100787)1.89676005
62Generalized hypopigmentation of hair (HP:0011358)1.89401625
63Male pseudohermaphroditism (HP:0000037)1.85633732
64Postaxial foot polydactyly (HP:0001830)1.84957573
65Aplasia/Hypoplasia of the spleen (HP:0010451)1.83620600
66Retrobulbar optic neuritis (HP:0100654)1.83317874
67Optic neuritis (HP:0100653)1.83317874
68Inability to walk (HP:0002540)1.82951383
69Constricted visual fields (HP:0001133)1.82414129
70Abnormal urine output (HP:0012590)1.79468719
71Retinitis pigmentosa (HP:0000510)1.78883481
72Elevated erythrocyte sedimentation rate (HP:0003565)1.78860977
73Hypoplasia of the fovea (HP:0007750)1.78742890
74Aplasia/Hypoplasia of the fovea (HP:0008060)1.78742890
75Supernumerary spleens (HP:0009799)1.78642047
76Increased hepatocellular lipid droplets (HP:0006565)1.78618559
77Methylmalonic aciduria (HP:0012120)1.78338060
78Intestinal atresia (HP:0011100)1.78191394
79Abnormality of the prostate (HP:0008775)1.77551545
80Polyphagia (HP:0002591)1.77477561
81Hypoplasia of the pons (HP:0012110)1.77326267
82Large for gestational age (HP:0001520)1.76886324
83Increased serum lactate (HP:0002151)1.76862180
84Congenital, generalized hypertrichosis (HP:0004540)1.76390645
85Dynein arm defect of respiratory motile cilia (HP:0012255)1.76186830
86Absent/shortened dynein arms (HP:0200106)1.76186830
87Lipid accumulation in hepatocytes (HP:0006561)1.75742277
88Abnormal delayed hypersensitivity skin test (HP:0002963)1.75673952
89Abnormality of renal excretion (HP:0011036)1.75411537
90Retinal dysplasia (HP:0007973)1.75066272
91Thyroiditis (HP:0100646)1.73635615
92Abnormal mitochondria in muscle tissue (HP:0008316)1.73315878
93Bony spicule pigmentary retinopathy (HP:0007737)1.73143802
94Photophobia (HP:0000613)1.72116372
95Febrile seizures (HP:0002373)1.71667042
96Methylmalonic acidemia (HP:0002912)1.71187160
97Progressive microcephaly (HP:0000253)1.70363745
98Genital tract atresia (HP:0001827)1.70137052
99Asplenia (HP:0001746)1.68971520
100Pancreatic islet-cell hyperplasia (HP:0004510)1.67478660

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.09086208
2TAOK33.99120268
3ADRBK23.48885054
4MAP4K23.18688334
5NUAK12.66508932
6PINK12.52435308
7WNK32.20360736
8BMPR1B2.16729219
9TRIM282.11507651
10OXSR12.09281077
11ZAK2.08287427
12INSRR1.97898526
13TXK1.91852546
14BMPR21.89324770
15GRK11.83666133
16EIF2AK31.80705816
17MST41.77799919
18BCR1.72023027
19STK391.60963523
20CSNK1G31.48745633
21CSNK1A1L1.37983063
22CSNK1G11.30892246
23PAK31.30263046
24MAPK131.28519059
25PLK21.27371104
26CSNK1G21.26408556
27CDK191.18507215
28PIK3CG1.18046636
29WNK41.16190134
30PRKCE1.11676902
31CLK11.10305322
32CASK1.06079349
33MAP3K41.05268122
34VRK21.05179339
35ADRBK11.01202074
36IKBKB0.98769047
37MAPKAPK50.95946825
38ERBB30.95567471
39VRK10.95505795
40PTK2B0.94929444
41MUSK0.94466767
42SIK30.88533811
43TEC0.84795418
44TIE10.80054970
45TLK10.80031433
46PRKCQ0.79689859
47TNIK0.78655927
48BCKDK0.76784918
49DYRK20.76604076
50PRKCI0.76101047
51KIT0.75109624
52CSF1R0.74479752
53STK30.73106848
54PLK30.68333388
55GRK60.66864763
56GRK50.66687908
57STK38L0.64387860
58IKBKE0.63258213
59STK160.61149359
60MAP3K120.59496037
61SYK0.58400453
62EGFR0.58290659
63ACVR1B0.56954422
64TNK20.56179278
65MAP3K140.55610187
66ERBB20.55074883
67DAPK20.54638360
68GRK70.54453047
69MAP2K70.54205427
70MARK30.51512374
71LYN0.48365446
72PRKCG0.48218612
73IGF1R0.47168404
74PLK10.47072289
75ITK0.46904356
76TYK20.46857970
77FER0.44831622
78FLT30.43873185
79CDK80.43631895
80MAP2K60.43364747
81FES0.42936477
82MAP4K10.42611361
83MKNK20.40805897
84ATR0.40029985
85DYRK1A0.39720078
86CSNK1D0.38772306
87PRKACA0.36407028
88ABL10.35940789
89CHUK0.33634705
90CAMKK20.31725180
91CAMK2A0.31400155
92JAK30.31309132
93BTK0.31291101
94IRAK10.31191102
95EIF2AK20.30734280
96TGFBR10.30508751
97PRKCA0.30424499
98LCK0.30363719
99CSNK1A10.30313011
100PRKG10.29590885

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053103.04188796
2Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.68378856
3Allograft rejection_Homo sapiens_hsa053302.56240483
4Intestinal immune network for IgA production_Homo sapiens_hsa046722.51135991
5Protein export_Homo sapiens_hsa030602.47632800
6Phototransduction_Homo sapiens_hsa047442.46372595
7Graft-versus-host disease_Homo sapiens_hsa053322.45389180
8Autoimmune thyroid disease_Homo sapiens_hsa053202.44422135
9Basal transcription factors_Homo sapiens_hsa030222.37642435
10Type I diabetes mellitus_Homo sapiens_hsa049402.36689361
11Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.25909330
12Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.22989541
13Linoleic acid metabolism_Homo sapiens_hsa005912.09701815
14alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.01522573
15SNARE interactions in vesicular transport_Homo sapiens_hsa041301.97286802
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.91107358
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.82606424
18Proteasome_Homo sapiens_hsa030501.80697024
19Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.76033080
20Nitrogen metabolism_Homo sapiens_hsa009101.73815705
21RNA polymerase_Homo sapiens_hsa030201.70540460
22Fanconi anemia pathway_Homo sapiens_hsa034601.68759060
23Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.65140159
24Regulation of autophagy_Homo sapiens_hsa041401.63292133
25RNA degradation_Homo sapiens_hsa030181.62881189
26Oxidative phosphorylation_Homo sapiens_hsa001901.61885043
27Homologous recombination_Homo sapiens_hsa034401.57391536
28Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.49374382
29Ether lipid metabolism_Homo sapiens_hsa005651.43781391
30Butanoate metabolism_Homo sapiens_hsa006501.33379405
31Staphylococcus aureus infection_Homo sapiens_hsa051501.32799529
32Rheumatoid arthritis_Homo sapiens_hsa053231.31698063
33Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.26489928
34Selenocompound metabolism_Homo sapiens_hsa004501.26398601
35Parkinsons disease_Homo sapiens_hsa050121.24817907
36Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.23652482
37Olfactory transduction_Homo sapiens_hsa047401.19817370
38Collecting duct acid secretion_Homo sapiens_hsa049661.19771453
39Primary immunodeficiency_Homo sapiens_hsa053401.11400451
40Propanoate metabolism_Homo sapiens_hsa006401.08637328
41Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.08111749
42Antigen processing and presentation_Homo sapiens_hsa046121.06893406
43Caffeine metabolism_Homo sapiens_hsa002321.01971467
44One carbon pool by folate_Homo sapiens_hsa006700.94475823
45Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.93804087
46Tryptophan metabolism_Homo sapiens_hsa003800.92456535
47Viral myocarditis_Homo sapiens_hsa054160.91873209
48Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.90463121
49Arachidonic acid metabolism_Homo sapiens_hsa005900.89730315
50Morphine addiction_Homo sapiens_hsa050320.88521087
51Non-homologous end-joining_Homo sapiens_hsa034500.82005660
52ABC transporters_Homo sapiens_hsa020100.81976758
53Dorso-ventral axis formation_Homo sapiens_hsa043200.81436796
54Peroxisome_Homo sapiens_hsa041460.80967827
55Hematopoietic cell lineage_Homo sapiens_hsa046400.79565856
56Nicotine addiction_Homo sapiens_hsa050330.77646144
57Steroid hormone biosynthesis_Homo sapiens_hsa001400.75953338
58Purine metabolism_Homo sapiens_hsa002300.73146008
59Taste transduction_Homo sapiens_hsa047420.72171061
60Ovarian steroidogenesis_Homo sapiens_hsa049130.71780544
61Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.71044818
62Pyrimidine metabolism_Homo sapiens_hsa002400.69446294
63Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.67647546
64Chemical carcinogenesis_Homo sapiens_hsa052040.66908017
65Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.66572620
66Huntingtons disease_Homo sapiens_hsa050160.65771487
67Nucleotide excision repair_Homo sapiens_hsa034200.63259096
68Leishmaniasis_Homo sapiens_hsa051400.60572116
69Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.59997030
70Alzheimers disease_Homo sapiens_hsa050100.59484405
71Primary bile acid biosynthesis_Homo sapiens_hsa001200.58069110
72Jak-STAT signaling pathway_Homo sapiens_hsa046300.57516600
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.57008993
74Herpes simplex infection_Homo sapiens_hsa051680.56062063
75Legionellosis_Homo sapiens_hsa051340.55973953
76Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.55312731
77GABAergic synapse_Homo sapiens_hsa047270.55291560
78NOD-like receptor signaling pathway_Homo sapiens_hsa046210.53968875
79Tuberculosis_Homo sapiens_hsa051520.52646600
80Maturity onset diabetes of the young_Homo sapiens_hsa049500.51969601
81Steroid biosynthesis_Homo sapiens_hsa001000.51433651
82Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.51134167
83Phagosome_Homo sapiens_hsa041450.50629015
84Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49731759
85RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.48865600
86Base excision repair_Homo sapiens_hsa034100.48363259
87Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.47081728
88Serotonergic synapse_Homo sapiens_hsa047260.46356697
89RNA transport_Homo sapiens_hsa030130.45071491
90Metabolic pathways_Homo sapiens_hsa011000.43466420
91Glycerolipid metabolism_Homo sapiens_hsa005610.38448704
92beta-Alanine metabolism_Homo sapiens_hsa004100.37392863
93Sphingolipid metabolism_Homo sapiens_hsa006000.34038287
94Cysteine and methionine metabolism_Homo sapiens_hsa002700.33224676
95Retinol metabolism_Homo sapiens_hsa008300.33192718
96Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.33126132
97Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.31192407
98Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.30732378
99Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.30109530
100p53 signaling pathway_Homo sapiens_hsa041150.29989732

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