CLEC4E

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type II transmembrane protein is a downstream target of CCAAT/enhancer binding protein (C/EBP), beta (CEBPB) and may play a role in inflammation. Alternative splice variants have been described but their full-length sequence has not been determined. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation by symbiont of host defense response (GO:0052509)6.97704450
2modulation by symbiont of host defense response (GO:0052031)6.97704450
3modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.97704450
4modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.97704450
5positive regulation by organism of defense response of other organism involved in symbiotic interact6.97704450
6modulation by symbiont of host immune response (GO:0052553)6.97704450
7response to peptidoglycan (GO:0032494)6.01504610
8negative regulation of cell killing (GO:0031342)5.50682337
9negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.50682337
10neutrophil activation involved in immune response (GO:0002283)5.46843985
11positive regulation of chemokine biosynthetic process (GO:0045080)5.21537285
12antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.90153860
13macrophage activation involved in immune response (GO:0002281)4.89766094
14hydrogen peroxide biosynthetic process (GO:0050665)4.79520730
15response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.70924390
16response to host immune response (GO:0052572)4.70924390
17detection of other organism (GO:0098543)4.69967006
18positive regulation of heat generation (GO:0031652)4.64918719
19lipopolysaccharide-mediated signaling pathway (GO:0031663)4.62348254
20positive regulation of interferon-alpha production (GO:0032727)4.57340759
21cellular extravasation (GO:0045123)4.56657765
22detection of external biotic stimulus (GO:0098581)4.50499740
23respiratory burst (GO:0045730)4.42778309
24regulation of interferon-alpha production (GO:0032647)4.41672540
25positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.30405389
26regulation of B cell receptor signaling pathway (GO:0050855)4.28587603
27regulation of fever generation (GO:0031620)4.28574060
28immunoglobulin mediated immune response (GO:0016064)4.28316444
29reactive oxygen species biosynthetic process (GO:1903409)4.26762342
30detection of bacterium (GO:0016045)4.24586018
31regulation of interferon-beta biosynthetic process (GO:0045357)4.24144086
32positive regulation of cellular amide metabolic process (GO:0034250)4.22723915
33regulation of chemokine biosynthetic process (GO:0045073)4.20986481
34response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.20149216
35response to host (GO:0075136)4.20149216
36response to host defenses (GO:0052200)4.20149216
37response to muramyl dipeptide (GO:0032495)4.19940174
38antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.12431873
39superoxide anion generation (GO:0042554)4.08229339
40antigen processing and presentation of endogenous antigen (GO:0019883)4.02028597
41positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.01715567
42granulocyte activation (GO:0036230)4.00817907
43positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.99117475
44microglial cell activation (GO:0001774)3.97778587
45natural killer cell mediated immunity (GO:0002228)3.95931665
46natural killer cell mediated cytotoxicity (GO:0042267)3.95931665
47regulation of gamma-delta T cell activation (GO:0046643)3.90028918
48leukocyte migration involved in inflammatory response (GO:0002523)3.81316609
49negative regulation of lymphocyte mediated immunity (GO:0002707)3.79557242
50neutrophil activation (GO:0042119)3.76739419
51positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.72334465
52antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.69655616
53negative regulation of interleukin-12 production (GO:0032695)3.69555747
54detection of molecule of bacterial origin (GO:0032490)3.65150297
55positive regulation of mast cell activation involved in immune response (GO:0033008)3.63162631
56positive regulation of mast cell degranulation (GO:0043306)3.63162631
57neutrophil mediated immunity (GO:0002446)3.62881213
58positive regulation of gamma-delta T cell activation (GO:0046645)3.61497602
59myeloid cell activation involved in immune response (GO:0002275)3.58065036
60positive regulation of interferon-beta production (GO:0032728)3.54450756
61negative regulation of T cell mediated immunity (GO:0002710)3.53321561
62macrophage activation (GO:0042116)3.52384843
63regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.49242757
64I-kappaB phosphorylation (GO:0007252)3.47943407
65regulation of heat generation (GO:0031650)3.47204506
66positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.45541729
67leukocyte aggregation (GO:0070486)3.42856852
68regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.42258391
69regulation of chronic inflammatory response (GO:0002676)3.40396229
70regulation of mononuclear cell migration (GO:0071675)3.39870865
71myeloid leukocyte mediated immunity (GO:0002444)3.38807190
72positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.36492563
73production of molecular mediator involved in inflammatory response (GO:0002532)3.36421300
74type I interferon signaling pathway (GO:0060337)3.36094300
75cellular response to type I interferon (GO:0071357)3.36094300
76leukocyte mediated cytotoxicity (GO:0001909)3.36010322
77regulation of mast cell degranulation (GO:0043304)3.35131327
78response to type I interferon (GO:0034340)3.33166260
79positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.32599688
80regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.30718049
81negative regulation of leukocyte mediated immunity (GO:0002704)3.29169348
82cytokine secretion (GO:0050663)3.27178543
83regulation of tolerance induction (GO:0002643)3.27061145
84interferon-gamma-mediated signaling pathway (GO:0060333)3.26678492
85response to interleukin-15 (GO:0070672)3.25685945
86regulation of dendritic cell antigen processing and presentation (GO:0002604)3.25159111
87positive regulation of mast cell activation (GO:0033005)3.24894564
88negative regulation of interleukin-17 production (GO:0032700)3.24232505
89negative regulation of viral genome replication (GO:0045071)3.24125587
90negative regulation of myeloid cell apoptotic process (GO:0033033)3.23446252
91regulation of podosome assembly (GO:0071801)3.23037213
92defense response to protozoan (GO:0042832)3.22224772
93T-helper 1 type immune response (GO:0042088)3.22164779
94regulation of T cell tolerance induction (GO:0002664)3.21366267
95response to protozoan (GO:0001562)3.19383039
96regulation of T-helper 2 cell differentiation (GO:0045628)3.18228206
97positive regulation of interleukin-1 beta secretion (GO:0050718)3.16471053
98positive regulation of chemokine production (GO:0032722)3.15899475
99negative regulation of cytokine production involved in immune response (GO:0002719)3.15773657
100regulation of mast cell activation involved in immune response (GO:0033006)3.15043190
101neutrophil chemotaxis (GO:0030593)3.14846682
102regulation of heterotypic cell-cell adhesion (GO:0034114)3.14325821
103regulation of interleukin-8 biosynthetic process (GO:0045414)3.13531955
104NIK/NF-kappaB signaling (GO:0038061)3.12635795
105B cell mediated immunity (GO:0019724)3.12458795
106regulation of myeloid leukocyte mediated immunity (GO:0002886)3.10049642
107positive regulation of antigen processing and presentation (GO:0002579)3.09683501
108positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.08941396
109regulation of vitamin D biosynthetic process (GO:0060556)3.08300276
110negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.07583533
111neutrophil migration (GO:1990266)3.06683634
112positive regulation of toll-like receptor signaling pathway (GO:0034123)3.04499326
113cellular response to interleukin-15 (GO:0071350)3.04296141
114positive regulation of NF-kappaB import into nucleus (GO:0042346)3.04167940
115myeloid leukocyte activation (GO:0002274)3.03670646
116modulation by symbiont of host cellular process (GO:0044068)3.02473875
117germinal center formation (GO:0002467)3.01355908
118detection of biotic stimulus (GO:0009595)3.00288929
119positive regulation of type 2 immune response (GO:0002830)3.00261471
120positive regulation of interleukin-12 production (GO:0032735)2.97253236
121regulation of interleukin-12 biosynthetic process (GO:0045075)2.96707724
122cellular response to virus (GO:0098586)2.96405554
123cellular response to lipopolysaccharide (GO:0071222)2.95725749
124cellular response to molecule of bacterial origin (GO:0071219)2.95606219
125low-density lipoprotein particle clearance (GO:0034383)2.94644611
126regulation of gamma-delta T cell differentiation (GO:0045586)2.94011358
127leukocyte degranulation (GO:0043299)2.93946865
128regulation of mast cell activation (GO:0033003)2.93684039
129regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.93219174
130positive regulation of interleukin-1 secretion (GO:0050716)2.92784291
131dendritic cell chemotaxis (GO:0002407)2.92428471
132positive regulation of interleukin-6 production (GO:0032755)2.92233201
133positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.92231853
134negative regulation of lipid storage (GO:0010888)2.91696833
135regulation of leukocyte degranulation (GO:0043300)2.90570667
136dendritic cell migration (GO:0036336)2.90035526
137regulation of interleukin-12 production (GO:0032655)2.89198146
138regulation of T-helper 1 cell differentiation (GO:0045625)2.88953351
139negative regulation of interleukin-6 production (GO:0032715)2.86216704
140positive regulation of tolerance induction (GO:0002645)2.85395871

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse7.36824576
2BP1_19119308_ChIP-ChIP_Hs578T_Human7.01334760
3IRF8_22096565_ChIP-ChIP_GC-B_Human6.95378044
4IRF8_27001747_Chip-Seq_BMDM_Mouse4.58868366
5SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse4.48640167
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.43281571
7Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse4.26889022
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.02051568
9NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.98335630
10RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.50915085
11* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.28376876
12MYB_21317192_ChIP-Seq_ERMYB_Mouse3.22458113
13EGR1_19374776_ChIP-ChIP_THP-1_Human3.20369136
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.88867017
15FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.77486668
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.73820292
17STAT4_19710469_ChIP-ChIP_TH1__Mouse2.49876051
18SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.49736350
19NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.38897266
20BRD4_27068464_Chip-Seq_AML-cells_Mouse2.15070268
21PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse2.09423959
22SPI1_23547873_ChIP-Seq_NB4_Human2.06248265
23NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.05019000
24PU_27001747_Chip-Seq_BMDM_Mouse1.80430052
25VDR_24787735_ChIP-Seq_THP-1_Human1.80390259
26STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.75911845
27PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.75674216
28VDR_24763502_ChIP-Seq_THP-1_Human1.75472035
29STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.75110044
30* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.72411988
31SCL_19346495_ChIP-Seq_HPC-7_Human1.70049299
32SPI1_23127762_ChIP-Seq_K562_Human1.69742957
33CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.67329269
34CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.64521268
35ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.53369490
36RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.52036870
37* RUNX1_22412390_ChIP-Seq_EML_Mouse1.49957399
38SMAD_19615063_ChIP-ChIP_OVARY_Human1.46894712
39MYB_26560356_Chip-Seq_TH2_Human1.46301907
40RUNX_20019798_ChIP-Seq_JUKART_Human1.41369815
41VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.40208061
42CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.39791114
43THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.39310320
44NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.37184774
45CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.35598574
46FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.32985246
47MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.32610713
48TP63_17297297_ChIP-ChIP_HaCaT_Human1.30940827
49MAF_26560356_Chip-Seq_TH1_Human1.30241640
50STAT6_21828071_ChIP-Seq_BEAS2B_Human1.29407575
51GATA2_21666600_ChIP-Seq_HMVEC_Human1.28706959
52PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.22993810
53MYB_26560356_Chip-Seq_TH1_Human1.20630601
54CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.18092078
55* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.17339457
56PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17277752
57* VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.13861321
58GATA3_26560356_Chip-Seq_TH2_Human1.12939142
59* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.08468869
60GATA3_27048872_Chip-Seq_THYMUS_Human1.06140130
61VDR_21846776_ChIP-Seq_THP-1_Human1.06109193
62TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.05202869
63GATA1_22025678_ChIP-Seq_K562_Human1.04707064
64E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.03953722
65FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.03553847
66* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.03383731
67SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.02293850
68TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00600856
69CDX2_19796622_ChIP-Seq_MESCs_Mouse0.99573460
70KDM2B_26808549_Chip-Seq_DND41_Human0.98811777
71GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98342849
72BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.97090290
73NRF2_20460467_ChIP-Seq_MEFs_Mouse0.95225364
74NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.95225364
75GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94969822
76SMRT_27268052_Chip-Seq_Bcells_Human0.93706025
77UTX_26944678_Chip-Seq_JUKART_Human0.91884749
78RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.84369668
79EGR1_19032775_ChIP-ChIP_M12_Human0.83765962
80TFEB_21752829_ChIP-Seq_HELA_Human0.83242508
81IKZF1_21737484_ChIP-ChIP_HCT116_Human0.83106708
82SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83078921
83MYC_22102868_ChIP-Seq_BL_Human0.81951440
84SOX2_20726797_ChIP-Seq_SW620_Human0.81620931
85KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.81475062
86GATA1_19941827_ChIP-Seq_MEL86_Mouse0.80855083
87GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.79907922
88CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.79565447
89CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.79461299
90* LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.79257221
91JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.78147795
92SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.77192768
93STAT1_20625510_ChIP-Seq_HELA_Human0.76976317
94JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.75939069
95SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.75572362
96SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.75572362
97SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.75158341
98KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.74613999
99ELK3_25401928_ChIP-Seq_HUVEC_Human0.74383751
100GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73883885
101PU.1_20513432_ChIP-Seq_Bcells_Mouse0.73071375
102BCL6_27268052_Chip-Seq_Bcells_Human0.72245326
103GATA2_19941826_ChIP-Seq_K562_Human0.71532424
104TCF7_22412390_ChIP-Seq_EML_Mouse0.71184109
105BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.69215623
106SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.68383156
107GATA1_19941827_ChIP-Seq_MEL_Mouse0.68230345
108TRIM28_21343339_ChIP-Seq_HEK293_Human0.66082597
109* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.63845407
110MAF_26560356_Chip-Seq_TH2_Human0.63793490
111BCOR_27268052_Chip-Seq_Bcells_Human0.63768158
112RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.62094055
113RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.62061947
114GATA3_26560356_Chip-Seq_TH1_Human0.61930105
115* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.61386670
116CJUN_26792858_Chip-Seq_BT549_Human0.61301296
117GATA1_19941826_ChIP-Seq_K562_Human0.60585712
118SPI1_20517297_ChIP-Seq_HL60_Human0.59762033
119ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.57366332
120KDM2B_26808549_Chip-Seq_SUP-B15_Human0.57256013
121CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.56791626

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009785_altered_susceptibility_to4.09196289
2MP0001835_abnormal_antigen_presentation4.06583794
3MP0003436_decreased_susceptibility_to4.03678060
4MP0003303_peritoneal_inflammation3.78823829
5MP0002148_abnormal_hypersensitivity_rea3.38184218
6* MP0002419_abnormal_innate_immunity3.35578380
7MP0003724_increased_susceptibility_to3.32512353
8MP0005000_abnormal_immune_tolerance3.25159048
9MP0006082_CNS_inflammation3.07072979
10* MP0005025_abnormal_response_to3.00934921
11MP0005058_abnormal_lysosome_morphology2.78007344
12MP0001790_abnormal_immune_system2.69026077
13MP0005387_immune_system_phenotype2.69026077
14MP0004510_myositis2.66545060
15MP0009278_abnormal_bone_marrow2.58730357
16* MP0002452_abnormal_antigen_presenting2.58002332
17MP0000685_abnormal_immune_system2.51141745
18MP0000569_abnormal_digit_pigmentation2.49368033
19* MP0002723_abnormal_immune_serum2.44684479
20MP0001800_abnormal_humoral_immune2.42718126
21MP0004947_skin_inflammation2.38473787
22MP0005464_abnormal_platelet_physiology2.27290237
23MP0001533_abnormal_skeleton_physiology2.24471123
24MP0005671_abnormal_response_to2.24028383
25MP0003172_abnormal_lysosome_physiology2.19255835
26* MP0001819_abnormal_immune_cell2.12703383
27* MP0002420_abnormal_adaptive_immunity2.09040921
28MP0009764_decreased_sensitivity_to2.08612488
29MP0003448_altered_tumor_morphology2.00518872
30MP0001845_abnormal_inflammatory_respons1.93533264
31MP0003075_altered_response_to1.89465195
32MP0005167_abnormal_blood-brain_barrier1.89096179
33MP0000343_altered_response_to1.87103284
34MP0002405_respiratory_system_inflammati1.77609258
35MP0008469_abnormal_protein_level1.75991676
36MP0001853_heart_inflammation1.69635388
37MP0002006_tumorigenesis1.67735761
38MP0010155_abnormal_intestine_physiology1.64548541
39MP0000604_amyloidosis1.64068836
40MP0001545_abnormal_hematopoietic_system1.61598351
41MP0005397_hematopoietic_system_phenotyp1.61598351
42MP0002998_abnormal_bone_remodeling1.52683416
43MP0000858_altered_metastatic_potential1.46096578
44* MP0000716_abnormal_immune_system1.41598206
45MP0005451_abnormal_body_composition1.39649342
46MP0004858_abnormal_nervous_system1.38873399
47MP0002132_abnormal_respiratory_system1.37841062
48MP0008260_abnormal_autophagy1.36408723
49MP0000465_gastrointestinal_hemorrhage1.36168525
50MP0003195_calcinosis1.33900744
51MP0005164_abnormal_response_to1.33560096
52MP0002398_abnormal_bone_marrow1.32410589
53MP0009333_abnormal_splenocyte_physiolog1.31285683
54MP0005166_decreased_susceptibility_to1.30277615
55MP0003183_abnormal_peptide_metabolism1.27987712
56MP0003300_gastrointestinal_ulcer1.26195963
57MP0005310_abnormal_salivary_gland1.22248524
58MP0008004_abnormal_stomach_pH1.21556380
59MP0005076_abnormal_cell_differentiation1.20036565
60MP0003806_abnormal_nucleotide_metabolis1.18448614
61MP0005174_abnormal_tail_pigmentation1.17549345
62MP0003186_abnormal_redox_activity1.17331132
63MP0003828_pulmonary_edema1.16665795
64MP0000689_abnormal_spleen_morphology1.12455645
65* MP0002429_abnormal_blood_cell1.10727133
66MP0009840_abnormal_foam_cell1.10212296
67MP0006054_spinal_hemorrhage1.09374092
68MP0009763_increased_sensitivity_to1.08648546
69MP0010307_abnormal_tumor_latency1.08299318
70MP0002332_abnormal_exercise_endurance1.08215887
71MP0003866_abnormal_defecation1.07419580
72MP0002277_abnormal_respiratory_mucosa1.05362518
73MP0005390_skeleton_phenotype1.03356379
74MP0000371_diluted_coat_color1.02679340
75MP0003646_muscle_fatigue1.01539554
76MP0003191_abnormal_cellular_cholesterol1.00767313
77MP0003453_abnormal_keratinocyte_physiol1.00379237
78MP0004381_abnormal_hair_follicle1.00037150
79MP0002722_abnormal_immune_system0.99311569
80MP0002254_reproductive_system_inflammat0.96731064
81MP0004782_abnormal_surfactant_physiolog0.92716648
82MP0003656_abnormal_erythrocyte_physiolo0.91349796
83MP0001851_eye_inflammation0.90626104
84MP0000703_abnormal_thymus_morphology0.88949905
85MP0003690_abnormal_glial_cell0.88785836
86MP0002933_joint_inflammation0.87317729
87MP0000015_abnormal_ear_pigmentation0.86907821
88MP0003045_fibrosis0.86626071
89MP0002138_abnormal_hepatobiliary_system0.85911296
90MP0002166_altered_tumor_susceptibility0.85744714
91MP0001663_abnormal_digestive_system0.85513450
92MP0003566_abnormal_cell_adhesion0.83845895
93MP0000249_abnormal_blood_vessel0.82543108
94MP0003091_abnormal_cell_migration0.81579586
95MP0010352_gastrointestinal_tract_polyps0.76246937
96MP0005083_abnormal_biliary_tract0.75919443
97MP0003221_abnormal_cardiomyocyte_apopto0.74366354
98MP0008874_decreased_physiological_sensi0.71338829
99MP0001501_abnormal_sleep_pattern0.69287848
100MP0000920_abnormal_myelination0.64421520
101MP0005257_abnormal_intraocular_pressure0.64014590
102MP0005023_abnormal_wound_healing0.63564815
103MP0003795_abnormal_bone_structure0.63175119
104MP0002396_abnormal_hematopoietic_system0.63109979
105MP0004883_abnormal_blood_vessel0.59991976
106MP0002136_abnormal_kidney_physiology0.57910272
107MP0002693_abnormal_pancreas_physiology0.55761962
108MP0008873_increased_physiological_sensi0.54760128
109MP0004808_abnormal_hematopoietic_stem0.54708409
110MP0005376_homeostasis/metabolism_phenot0.54644756
111MP0000767_abnormal_smooth_muscle0.52959664
112MP0001958_emphysema0.51429281
113MP0001873_stomach_inflammation0.51032620
114MP0005319_abnormal_enzyme/_coenzyme0.49426591
115MP0009765_abnormal_xenobiotic_induced0.48289159
116MP0005075_abnormal_melanosome_morpholog0.48017018
117MP0004130_abnormal_muscle_cell0.47595531
118MP0005197_abnormal_uvea_morphology0.46927292
119MP0001191_abnormal_skin_condition0.45983894
120MP0005535_abnormal_body_temperature0.43825380
121MP0003763_abnormal_thymus_physiology0.43807962

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)8.20648602
2Recurrent bacterial skin infections (HP:0005406)7.53090650
3Eczematoid dermatitis (HP:0000976)7.40612607
4Recurrent gram-negative bacterial infections (HP:0005420)6.71395449
5Stomatitis (HP:0010280)6.44676785
6Mediastinal lymphadenopathy (HP:0100721)5.79103644
7Abnormality of macrophages (HP:0004311)5.66538417
8Elevated erythrocyte sedimentation rate (HP:0003565)5.50681741
9Gingivitis (HP:0000230)4.72620996
10Autoimmune thrombocytopenia (HP:0001973)4.53709583
11Retrobulbar optic neuritis (HP:0100654)4.48253551
12Optic neuritis (HP:0100653)4.48253551
13Orchitis (HP:0100796)4.43901968
14Recurrent skin infections (HP:0001581)4.35380062
15Myositis (HP:0100614)4.19615137
16Prostate neoplasm (HP:0100787)4.03298265
17Obstructive lung disease (HP:0006536)4.02429660
18Chronic obstructive pulmonary disease (HP:0006510)4.02429660
19Increased cerebral lipofuscin (HP:0011813)3.99874778
20Vacuolated lymphocytes (HP:0001922)3.91075846
21Increased neuronal autofluorescent lipopigment (HP:0002074)3.83645762
22Vasculitis (HP:0002633)3.73757884
23Recurrent fungal infections (HP:0002841)3.68270345
24Thick nail (HP:0001805)3.63663049
25Encephalitis (HP:0002383)3.61353593
26Spontaneous hematomas (HP:0007420)3.49432216
27Urticaria (HP:0001025)3.37863606
28Periodontitis (HP:0000704)3.33847420
29Abnormal delayed hypersensitivity skin test (HP:0002963)3.33068093
30Increased IgM level (HP:0003496)3.30406607
31Tetraparesis (HP:0002273)3.29820090
32Recurrent viral infections (HP:0004429)3.28534366
33Systemic lupus erythematosus (HP:0002725)3.25058664
34Pustule (HP:0200039)3.23243997
35T lymphocytopenia (HP:0005403)3.13030199
36Interstitial pulmonary disease (HP:0006530)3.11076615
37Abnormality of T cell number (HP:0011839)3.09255210
38Hypochromic microcytic anemia (HP:0004840)3.03464385
39Axonal loss (HP:0003447)3.00373736
40Pulmonary infiltrates (HP:0002113)3.00353053
41Leukocytosis (HP:0001974)2.94601242
42Basal ganglia calcification (HP:0002135)2.94468833
43Cellulitis (HP:0100658)2.92837111
44Chest pain (HP:0100749)2.91235713
45Increased IgE level (HP:0003212)2.88409783
46Gangrene (HP:0100758)2.83858684
47Hematochezia (HP:0002573)2.81221247
48Pulmonary embolism (HP:0002204)2.75115941
49Premature loss of primary teeth (HP:0006323)2.74496075
50Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.69842620
51Amyloidosis (HP:0011034)2.68729097
52Hypochromic anemia (HP:0001931)2.66893768
53Prolonged bleeding time (HP:0003010)2.65480487
54Osteomyelitis (HP:0002754)2.65027622
55Disinhibition (HP:0000734)2.62873518
56Abnormality of glycolipid metabolism (HP:0010969)2.61301397
57Abnormality of liposaccharide metabolism (HP:0010968)2.61301397
58Abnormality of glycosphingolipid metabolism (HP:0004343)2.61301397
59Loss of speech (HP:0002371)2.59195966
60Meningitis (HP:0001287)2.57252092
61Recurrent pneumonia (HP:0006532)2.56330314
62Recurrent cutaneous fungal infections (HP:0011370)2.51776346
63Chronic mucocutaneous candidiasis (HP:0002728)2.51776346
64Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.51669189
65Keratoconjunctivitis sicca (HP:0001097)2.51584001
66Esophageal neoplasm (HP:0100751)2.48907137
67Neoplasm of head and neck (HP:0012288)2.48907137
68Arterial thrombosis (HP:0004420)2.43720018
69Glomerulonephritis (HP:0000099)2.42796126
70Gingival bleeding (HP:0000225)2.40438152
71Epistaxis (HP:0000421)2.39005117
72Dysostosis multiplex (HP:0000943)2.38517862
73Chronic otitis media (HP:0000389)2.38032308
74Abnormality of T cells (HP:0002843)2.35017666
75Abnormality of the endocardium (HP:0004306)2.30778633
76Myocardial infarction (HP:0001658)2.30463233
77Nausea (HP:0002018)2.30387907
78Keratitis (HP:0000491)2.28631256
79Keratoconjunctivitis (HP:0001096)2.27274387
80Vertigo (HP:0002321)2.24158734
81Bone pain (HP:0002653)2.23692028
82Hemoptysis (HP:0002105)2.22483967
83Vertebral compression fractures (HP:0002953)2.21892983
84Inflammation of the large intestine (HP:0002037)2.21375248
85Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.20791315
86Granulocytopenia (HP:0001913)2.19932293
87Abnormality of the prostate (HP:0008775)2.19519101
88Recurrent lower respiratory tract infections (HP:0002783)2.19259288
89Hypergammaglobulinemia (HP:0010702)2.19218418
90Abnormality of iron homeostasis (HP:0011031)2.18031017
91Polyneuropathy (HP:0001271)2.17162069
92Acne (HP:0001061)2.15133065
93Microcytic anemia (HP:0001935)2.12577651
94Gastrointestinal infarctions (HP:0005244)2.10537579
95Glomerulopathy (HP:0100820)2.10407444
96Abnormality of the peritoneum (HP:0002585)2.07120449
97Osteolytic defects of the phalanges of the hand (HP:0009771)2.06815907
98Osteolytic defects of the hand bones (HP:0009699)2.06815907
99Gastrointestinal inflammation (HP:0004386)2.04434925
100Urinary glycosaminoglycan excretion (HP:0003541)2.01345779
101Mucopolysacchariduria (HP:0008155)2.01345779
102Hepatosplenomegaly (HP:0001433)2.01007723
103Increased serum ferritin (HP:0003281)1.98718503
104Purpura (HP:0000979)1.98273638
105Abnormality of mucopolysaccharide metabolism (HP:0011020)1.97175038
106Abnormality of polysaccharide metabolism (HP:0011012)1.97175038
107Abnormality of glycosaminoglycan metabolism (HP:0004371)1.97175038
108Pathologic fracture (HP:0002756)1.95900599
109Anorexia (HP:0002039)1.95765284
110Eosinophilia (HP:0001880)1.94168662
111Restrictive lung disease (HP:0002091)1.93574889
112Arthralgia (HP:0002829)1.93305145
113Poor head control (HP:0002421)1.92980918
114Nephritis (HP:0000123)1.92358721
115Abnormality of the pericardium (HP:0001697)1.91912615
116Sepsis (HP:0100806)1.90446758
117Lymphopenia (HP:0001888)1.90255155
118Porencephaly (HP:0002132)1.90020309
119Joint swelling (HP:0001386)1.88414631
120Abnormality of transition element cation homeostasis (HP:0011030)1.85851545
121Cheilitis (HP:0100825)1.85363352
122Joint hemorrhage (HP:0005261)1.85257263
123Petechiae (HP:0000967)1.83651368
124Mutism (HP:0002300)1.83580769
125Abnormality of T cell physiology (HP:0011840)1.81412694
126Acute hepatic failure (HP:0006554)1.81371268
127Abnormality of eosinophils (HP:0001879)1.81211077
128Peritonitis (HP:0002586)1.80960161
129Agnosia (HP:0010524)1.80828457
130Progressive visual loss (HP:0000529)1.80642726
131Abnormality of cells of the lymphoid lineage (HP:0012140)1.80453838
132Abnormality of the pleura (HP:0002103)1.79821201
133Skin ulcer (HP:0200042)1.77151742
134Autoimmune hemolytic anemia (HP:0001890)1.77033619
135Albinism (HP:0001022)1.76085471
136Gastrointestinal stroma tumor (HP:0100723)1.76066489
137Episodic fever (HP:0001954)1.75487553

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK45.47440195
2MAP3K145.02061214
3IRAK34.04985797
4TBK14.00236283
5PBK3.69818643
6BLK3.61060049
7IRAK43.32679759
8IKBKE3.15529549
9TYK22.95621642
10IKBKB2.52200117
11MAP3K132.29671007
12JAK32.29667394
13TXK2.24409411
14KIT2.10003974
15TAOK12.00847808
16MAP4K11.97873031
17TNK21.97592965
18JAK11.89980632
19GRK61.77525342
20FGR1.71066254
21ERN11.70783559
22CSK1.62168067
23CHUK1.61027107
24RPS6KA41.34606496
25MATK1.28820871
26PRPF4B1.23793344
27HCK1.22247980
28BMX1.22227006
29MARK31.21544070
30SYK1.19192306
31LYN1.18262425
32TAOK31.17129694
33ZAP701.16943832
34PIM21.11483812
35ACVR1B1.10321801
36FRK1.10000977
37LCK1.09185767
38FES1.02315699
39JAK21.02290956
40ABL21.01301276
41BMPR21.00864732
42PIM10.99008201
43CSF1R0.98591335
44MST1R0.96358407
45EIF2AK20.93920453
46YES10.93524231
47NME20.90609143
48EPHB10.87518591
49STK40.85382248
50ERBB40.82969008
51MAP3K50.82680779
52PTK2B0.81559073
53MAP3K60.81399617
54SIK20.80872735
55EGFR0.77752883
56BTK0.77029053
57DAPK20.75623380
58MST40.75398344
59MARK20.75269871
60PRKCD0.73829529
61MAP3K20.71737889
62SIK30.71110501
63NEK90.70965875
64MAP2K40.69753797
65ABL10.65964437
66CDC42BPA0.65234450
67RIPK10.64986230
68ADRBK20.64383094
69PIK3CG0.62950618
70MAP2K60.60892605
71KSR10.60399161
72TEC0.60001698
73STK100.59866765
74CAMKK20.59647846
75IRAK20.58368226
76DYRK30.57137540
77MAP3K110.56617102
78CDK190.55616784
79FGFR30.55575982
80TTN0.53999723
81PLK20.52924756
82DAPK30.52393411
83SGK30.50536291
84PRKD20.50063282
85MAP3K100.49346360
86MAP3K10.48503682
87STK110.48467108
88KSR20.48382785
89SGK20.47498954
90CDK120.45671841
91MAP2K30.45205390
92PTK60.44764029
93MAPK70.43345157
94RAF10.42491742
95HIPK20.41911700
96STK30.41795985
97IRAK10.40930118
98FYN0.40839591
99PDPK10.40654570
100FGFR40.39525496
101NLK0.38483090
102STK380.38460041
103MAP3K30.37082879
104TGFBR20.37056540
105MAPK120.37038352
106GRK70.35511484
107PRKCZ0.35402712
108LRRK20.34986189
109CLK10.34824198
110TRPM70.34363877
111PDK10.34021249
112PDGFRB0.33702473
113PRKG20.33591133
114MOS0.32937314
115DYRK1B0.31055246
116RPS6KL10.31008320
117RPS6KC10.31008320
118MAP3K70.29754236
119MAPKAPK20.29000144
120ERBB30.28433116
121RPS6KA60.28090032
122PRKCQ0.27369008
123PRKAA20.25333016
124TAOK20.25121913
125ALK0.22713566
126CAMK1D0.21149738
127PKN10.20843771
128INSR0.20412172
129CDK60.20052633
130RPS6KA20.19546046
131EPHA30.19346823
132ARAF0.18965815
133BMPR1B0.18886272
134SGK10.17623710
135ITK0.17238478
136SRC0.15854353

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.61909109
2Graft-versus-host disease_Homo sapiens_hsa053323.40266018
3Staphylococcus aureus infection_Homo sapiens_hsa051503.10866273
4Toll-like receptor signaling pathway_Homo sapiens_hsa046203.03056768
5NOD-like receptor signaling pathway_Homo sapiens_hsa046212.98602817
6Legionellosis_Homo sapiens_hsa051342.95282324
7NF-kappa B signaling pathway_Homo sapiens_hsa040642.78698683
8Malaria_Homo sapiens_hsa051442.56577751
9Pertussis_Homo sapiens_hsa051332.54929542
10Allograft rejection_Homo sapiens_hsa053302.50519242
11Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.47881937
12Osteoclast differentiation_Homo sapiens_hsa043802.41954931
13Rheumatoid arthritis_Homo sapiens_hsa053232.38670577
14TNF signaling pathway_Homo sapiens_hsa046682.29723459
15RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.25780672
16* Tuberculosis_Homo sapiens_hsa051522.20624458
17Asthma_Homo sapiens_hsa053102.19802015
18Type I diabetes mellitus_Homo sapiens_hsa049402.19671900
19African trypanosomiasis_Homo sapiens_hsa051432.02128656
20Measles_Homo sapiens_hsa051622.02110048
21Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.00265114
22Influenza A_Homo sapiens_hsa051641.92406442
23Salmonella infection_Homo sapiens_hsa051321.83414948
24Phagosome_Homo sapiens_hsa041451.76404171
25Hematopoietic cell lineage_Homo sapiens_hsa046401.60925232
26Lysosome_Homo sapiens_hsa041421.58231050
27B cell receptor signaling pathway_Homo sapiens_hsa046621.53652334
28Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.53154416
29Herpes simplex infection_Homo sapiens_hsa051681.47662449
30Toxoplasmosis_Homo sapiens_hsa051451.47222591
31Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.33471617
32Apoptosis_Homo sapiens_hsa042101.32516984
33Intestinal immune network for IgA production_Homo sapiens_hsa046721.27094622
34Chemokine signaling pathway_Homo sapiens_hsa040621.26100272
35Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.25916215
36Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.25751657
37Shigellosis_Homo sapiens_hsa051311.24785843
38Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.10260191
39Hepatitis C_Homo sapiens_hsa051601.10127549
40Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.07399397
41Amoebiasis_Homo sapiens_hsa051461.05980402
42Jak-STAT signaling pathway_Homo sapiens_hsa046301.05693884
43Hepatitis B_Homo sapiens_hsa051611.04343931
44AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.02171494
45Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.98221161
46Antigen processing and presentation_Homo sapiens_hsa046120.94809952
47Other glycan degradation_Homo sapiens_hsa005110.90297193
48Autoimmune thyroid disease_Homo sapiens_hsa053200.88295487
49Glycosaminoglycan degradation_Homo sapiens_hsa005310.88221055
50Viral myocarditis_Homo sapiens_hsa054160.79303077
51Type II diabetes mellitus_Homo sapiens_hsa049300.79096532
52T cell receptor signaling pathway_Homo sapiens_hsa046600.77610175
53Adipocytokine signaling pathway_Homo sapiens_hsa049200.75757657
54Collecting duct acid secretion_Homo sapiens_hsa049660.75130771
55Leukocyte transendothelial migration_Homo sapiens_hsa046700.74332492
56Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.73897279
57Neurotrophin signaling pathway_Homo sapiens_hsa047220.70052714
58Prion diseases_Homo sapiens_hsa050200.69029261
59Non-small cell lung cancer_Homo sapiens_hsa052230.68982453
60Acute myeloid leukemia_Homo sapiens_hsa052210.61899839
61Mineral absorption_Homo sapiens_hsa049780.60033106
62Epstein-Barr virus infection_Homo sapiens_hsa051690.59278689
63Chronic myeloid leukemia_Homo sapiens_hsa052200.56419218
64Primary immunodeficiency_Homo sapiens_hsa053400.55780068
65Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.54947895
66Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.54006682
67SNARE interactions in vesicular transport_Homo sapiens_hsa041300.53653163
68Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.51739945
69Sphingolipid signaling pathway_Homo sapiens_hsa040710.51564193
70Prolactin signaling pathway_Homo sapiens_hsa049170.50707047
71Complement and coagulation cascades_Homo sapiens_hsa046100.49876742
72HIF-1 signaling pathway_Homo sapiens_hsa040660.49111998
73Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.48874801
74Caffeine metabolism_Homo sapiens_hsa002320.47761749
75Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.45948823
76Platelet activation_Homo sapiens_hsa046110.45738062
77Regulation of autophagy_Homo sapiens_hsa041400.45590263
78Small cell lung cancer_Homo sapiens_hsa052220.44924524
79Pancreatic cancer_Homo sapiens_hsa052120.44924000
80GnRH signaling pathway_Homo sapiens_hsa049120.41369183
81Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.40084896
82Dorso-ventral axis formation_Homo sapiens_hsa043200.38184536
83Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.38041647
84Insulin resistance_Homo sapiens_hsa049310.34675657
85Choline metabolism in cancer_Homo sapiens_hsa052310.32994802
86Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.32642387
87Bladder cancer_Homo sapiens_hsa052190.32176364
88VEGF signaling pathway_Homo sapiens_hsa043700.28971820
89Regulation of actin cytoskeleton_Homo sapiens_hsa048100.28801173
90Viral carcinogenesis_Homo sapiens_hsa052030.28457153
91Phosphatidylinositol signaling system_Homo sapiens_hsa040700.26426688
92Sphingolipid metabolism_Homo sapiens_hsa006000.26250584
93Carbohydrate digestion and absorption_Homo sapiens_hsa049730.26137225
94Rap1 signaling pathway_Homo sapiens_hsa040150.25825450
95mTOR signaling pathway_Homo sapiens_hsa041500.25240569
96Proteoglycans in cancer_Homo sapiens_hsa052050.24524457
97Transcriptional misregulation in cancer_Homo sapiens_hsa052020.24314600
98Endometrial cancer_Homo sapiens_hsa052130.23737135
99MicroRNAs in cancer_Homo sapiens_hsa052060.23263497
100Notch signaling pathway_Homo sapiens_hsa043300.21587934
101FoxO signaling pathway_Homo sapiens_hsa040680.21441735
102MAPK signaling pathway_Homo sapiens_hsa040100.15675836
103HTLV-I infection_Homo sapiens_hsa051660.15292553
104Vibrio cholerae infection_Homo sapiens_hsa051100.14092092
105Endocytosis_Homo sapiens_hsa041440.13311553
106Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.12807634
107Renal cell carcinoma_Homo sapiens_hsa052110.12783214
108Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.08750895
109Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.07551450
110Phospholipase D signaling pathway_Homo sapiens_hsa040720.05084101

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