CLEC4F

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.58188665
2L-phenylalanine catabolic process (GO:0006559)7.58188665
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.25368307
4L-phenylalanine metabolic process (GO:0006558)7.25368307
5aromatic amino acid family catabolic process (GO:0009074)6.81659058
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.42873562
7tryptophan catabolic process (GO:0006569)6.14244517
8indole-containing compound catabolic process (GO:0042436)6.14244517
9indolalkylamine catabolic process (GO:0046218)6.14244517
10kynurenine metabolic process (GO:0070189)6.01205709
11bile acid biosynthetic process (GO:0006699)5.94600136
12detection of other organism (GO:0098543)5.87806504
13detection of bacterium (GO:0016045)5.86096462
14tryptophan metabolic process (GO:0006568)5.77871709
15glyoxylate metabolic process (GO:0046487)5.74039079
16negative regulation of fibrinolysis (GO:0051918)5.72565971
17positive regulation of gamma-delta T cell activation (GO:0046645)5.72435395
18urea metabolic process (GO:0019627)5.69935815
19urea cycle (GO:0000050)5.69935815
20high-density lipoprotein particle remodeling (GO:0034375)5.66586092
21alpha-linolenic acid metabolic process (GO:0036109)5.62301413
22complement activation, alternative pathway (GO:0006957)5.53371983
23regulation of fibrinolysis (GO:0051917)5.52407522
24response to peptidoglycan (GO:0032494)5.50781489
25protein carboxylation (GO:0018214)5.47322991
26peptidyl-glutamic acid carboxylation (GO:0017187)5.47322991
27negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.47022135
28negative regulation of cell killing (GO:0031342)5.47022135
29modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.45706027
30positive regulation by organism of defense response of other organism involved in symbiotic interact5.45706027
31modulation by symbiont of host immune response (GO:0052553)5.45706027
32positive regulation by symbiont of host defense response (GO:0052509)5.45706027
33modulation by symbiont of host defense response (GO:0052031)5.45706027
34modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.45706027
35positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)5.42465192
36regulation of protein activation cascade (GO:2000257)5.42348262
37sulfur amino acid catabolic process (GO:0000098)5.31195932
38cysteine metabolic process (GO:0006534)5.28613599
39nitrogen cycle metabolic process (GO:0071941)5.23749448
40antigen processing and presentation of endogenous antigen (GO:0019883)5.20471829
41serine family amino acid catabolic process (GO:0009071)5.11916802
42bile acid metabolic process (GO:0008206)5.10988999
43regulation of complement activation (GO:0030449)5.05423099
44neutrophil activation involved in immune response (GO:0002283)4.98295619
45regulation of cholesterol esterification (GO:0010872)4.98004947
46regulation of gamma-delta T cell activation (GO:0046643)4.97623552
47aromatic amino acid family metabolic process (GO:0009072)4.95046157
48reverse cholesterol transport (GO:0043691)4.94606250
49regulation of triglyceride catabolic process (GO:0010896)4.87751561
50plasma lipoprotein particle remodeling (GO:0034369)4.85479675
51protein-lipid complex remodeling (GO:0034368)4.85479675
52macromolecular complex remodeling (GO:0034367)4.85479675
53fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.84528003
54tyrosine metabolic process (GO:0006570)4.82400367
55regulation of tumor necrosis factor biosynthetic process (GO:0042534)4.74139541
56homocysteine metabolic process (GO:0050667)4.72300891
57antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.69166924
58alpha-amino acid catabolic process (GO:1901606)4.63409456
59phospholipid efflux (GO:0033700)4.63054317
60triglyceride homeostasis (GO:0070328)4.62572001
61acylglycerol homeostasis (GO:0055090)4.62572001
62negative regulation of cholesterol transport (GO:0032375)4.61521539
63negative regulation of sterol transport (GO:0032372)4.61521539
64amino-acid betaine metabolic process (GO:0006577)4.59323127
65negative regulation of erythrocyte differentiation (GO:0045647)4.58248867
66lysine catabolic process (GO:0006554)4.52664271
67lysine metabolic process (GO:0006553)4.52664271
68cellular ketone body metabolic process (GO:0046950)4.50693394
69immunoglobulin mediated immune response (GO:0016064)4.49505758
70plasma lipoprotein particle clearance (GO:0034381)4.44742658
71detection of external biotic stimulus (GO:0098581)4.43208914
72bile acid and bile salt transport (GO:0015721)4.42237659
73glycine metabolic process (GO:0006544)4.40592214
74macrophage activation involved in immune response (GO:0002281)4.38178610
75imidazole-containing compound metabolic process (GO:0052803)4.35813794
76indolalkylamine metabolic process (GO:0006586)4.34648328
77coenzyme catabolic process (GO:0009109)4.33778137
78antigen processing and presentation via MHC class Ib (GO:0002475)4.33633404
79cholesterol efflux (GO:0033344)4.29424794
80amine catabolic process (GO:0009310)4.25711217
81cellular biogenic amine catabolic process (GO:0042402)4.25711217
82cellular amino acid catabolic process (GO:0009063)4.25492390
83glutamate metabolic process (GO:0006536)4.23067482
84cellular glucuronidation (GO:0052695)4.21892357
85response to interleukin-15 (GO:0070672)4.18791043
86regulation of gamma-delta T cell differentiation (GO:0045586)4.17543454
87cellular response to interleukin-15 (GO:0071350)4.17333731
88positive regulation of mast cell activation (GO:0033005)4.17129721
89serine family amino acid metabolic process (GO:0009069)4.14223666
90regulation of mast cell degranulation (GO:0043304)4.13576095
91benzene-containing compound metabolic process (GO:0042537)4.12724708
92antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.12365771
93low-density lipoprotein particle remodeling (GO:0034374)4.10040394
94fibrinolysis (GO:0042730)4.08914802
95plasma lipoprotein particle assembly (GO:0034377)4.06451091
96negative regulation of interleukin-12 production (GO:0032695)4.06187164
97arginine metabolic process (GO:0006525)4.04237162
98cellular modified amino acid catabolic process (GO:0042219)4.03223562
99ethanol oxidation (GO:0006069)4.01321493
100dicarboxylic acid biosynthetic process (GO:0043650)4.00924664
101regulation of B cell receptor signaling pathway (GO:0050855)3.97909554
102detection of biotic stimulus (GO:0009595)3.97127132
103serine family amino acid biosynthetic process (GO:0009070)3.96950777
104response to muramyl dipeptide (GO:0032495)3.96746754
105drug catabolic process (GO:0042737)3.95922355
106aldehyde catabolic process (GO:0046185)3.95855917
107blood coagulation, intrinsic pathway (GO:0007597)3.95610452
108positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.91096136
109ketone body metabolic process (GO:1902224)3.90124635
110regulation of dendritic cell antigen processing and presentation (GO:0002604)3.88032830
111complement activation (GO:0006956)3.82400624
112positive regulation of triglyceride lipase activity (GO:0061365)3.82199889
113positive regulation of lipoprotein lipase activity (GO:0051006)3.82199889
114regulation of mast cell activation involved in immune response (GO:0033006)3.81771233
115protein activation cascade (GO:0072376)3.81538482
116cofactor catabolic process (GO:0051187)3.81486499
117complement activation, classical pathway (GO:0006958)3.81290138
118regulation of myeloid leukocyte mediated immunity (GO:0002886)3.80843984
119negative regulation of lipase activity (GO:0060192)3.79048458
120positive regulation of lipid catabolic process (GO:0050996)3.77726156
121cholesterol homeostasis (GO:0042632)3.76226069
122phospholipid homeostasis (GO:0055091)3.75161076
123very-low-density lipoprotein particle assembly (GO:0034379)3.74861841
124glucuronate metabolic process (GO:0019585)3.74303119
125uronic acid metabolic process (GO:0006063)3.74303119
126microglial cell activation (GO:0001774)3.74154958
127organic acid catabolic process (GO:0016054)3.72742109
128carboxylic acid catabolic process (GO:0046395)3.72742109
129sterol homeostasis (GO:0055092)3.69935197
130regulation of bile acid biosynthetic process (GO:0070857)3.69195366
131plasma lipoprotein particle organization (GO:0071827)3.68495797
132antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.66586659
133interferon-gamma-mediated signaling pathway (GO:0060333)3.65959601
134protein-lipid complex assembly (GO:0065005)3.64032488
135short-chain fatty acid metabolic process (GO:0046459)3.63754198
136opsonization (GO:0008228)3.62199501
137acetyl-CoA metabolic process (GO:0006084)3.61922405
138acute-phase response (GO:0006953)3.61629924
139cytolysis (GO:0019835)3.60461241
140regulation of cholesterol homeostasis (GO:2000188)3.60128515
141response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.59130123
142response to host immune response (GO:0052572)3.59130123
143regulation of mast cell activation (GO:0033003)3.58960594
144B cell mediated immunity (GO:0019724)3.57660718
145regulation of leukocyte degranulation (GO:0043300)3.56278898
146negative regulation of lymphocyte mediated immunity (GO:0002707)3.54085901
147positive regulation of cellular amide metabolic process (GO:0034250)3.52972566
148negative thymic T cell selection (GO:0045060)3.48546140
149detection of molecule of bacterial origin (GO:0032490)3.47757548
150regulation of antigen processing and presentation (GO:0002577)3.42865338
151positive regulation of interleukin-17 production (GO:0032740)3.40831726
152response to type I interferon (GO:0034340)3.39493290
153type I interferon signaling pathway (GO:0060337)3.39144872
154cellular response to type I interferon (GO:0071357)3.39144872
155neutrophil activation (GO:0042119)3.37892610
156response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.37737203
157response to host (GO:0075136)3.37737203
158response to host defenses (GO:0052200)3.37737203
159positive regulation of mast cell activation involved in immune response (GO:0033008)3.36967479
160positive regulation of mast cell degranulation (GO:0043306)3.36967479
161negative regulation of T cell mediated immunity (GO:0002710)3.35803697
162positive regulation of type 2 immune response (GO:0002830)3.34150162
163regulation of platelet aggregation (GO:0090330)3.32520797
164positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.31511175
165T cell selection (GO:0045058)3.28487070
166positive regulation of antigen processing and presentation (GO:0002579)3.28466958
167negative T cell selection (GO:0043383)3.25272427
168regulation of interferon-beta biosynthetic process (GO:0045357)3.23183203
169myeloid cell activation involved in immune response (GO:0002275)3.22877615
170regulation of T-helper 2 cell differentiation (GO:0045628)3.20208933
171mannose metabolic process (GO:0006013)3.19786890
172macrophage activation (GO:0042116)3.18958720
173negative regulation of leukocyte mediated immunity (GO:0002704)3.17494834
174positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)3.16558354
175positive thymic T cell selection (GO:0045059)3.13201162
176granulocyte activation (GO:0036230)3.10482720
177regulation of tolerance induction (GO:0002643)3.09545151
178regulation of regulated secretory pathway (GO:1903305)3.07578090
179myeloid dendritic cell activation (GO:0001773)3.05977096
180myeloid dendritic cell differentiation (GO:0043011)3.04974535
181positive regulation of B cell differentiation (GO:0045579)3.02648596
182defense response to protozoan (GO:0042832)3.02235792
183tolerance induction (GO:0002507)3.00691792
184lipopolysaccharide-mediated signaling pathway (GO:0031663)2.99504059
185positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.98115839
186positive regulation of tumor necrosis factor production (GO:0032760)2.98037433
187regulation of interleukin-17 production (GO:0032660)2.96430735
188regulation of T cell tolerance induction (GO:0002664)2.94421981
189positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.91061586
190leukocyte aggregation (GO:0070486)2.90458259
191B cell receptor signaling pathway (GO:0050853)2.88946947
192mucosal-associated lymphoid tissue development (GO:0048537)2.85013716
193Peyers patch development (GO:0048541)2.85013716
194negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.83649810
195negative regulation of cytokine production involved in immune response (GO:0002719)2.83010619
196production of molecular mediator involved in inflammatory response (GO:0002532)2.81483419
197leukocyte migration involved in inflammatory response (GO:0002523)2.79855319
198germinal center formation (GO:0002467)2.79718922
199T cell migration (GO:0072678)2.79321080
200regulation of type 2 immune response (GO:0002828)2.79308213

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse8.40375492
2PPARA_22158963_ChIP-Seq_LIVER_Mouse7.18516796
3EGR1_23403033_ChIP-Seq_LIVER_Mouse7.04144747
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.50939369
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.29710795
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.17802797
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.85059332
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.06375290
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.03619396
10BP1_19119308_ChIP-ChIP_Hs578T_Human3.99850588
11IRF8_21731497_ChIP-ChIP_J774_Mouse3.59405620
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.43030588
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.21449914
14SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.06820875
15SCL_19346495_ChIP-Seq_HPC-7_Human2.99921625
16IRF8_27001747_Chip-Seq_BMDM_Mouse2.99653351
17FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.93245597
18SPI1_23127762_ChIP-Seq_K562_Human2.63021113
19VDR_21846776_ChIP-Seq_THP-1_Human2.61468621
20NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.61384580
21MYB_21317192_ChIP-Seq_ERMYB_Mouse2.52388581
22IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.50081868
23VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.49395039
24VDR_24763502_ChIP-Seq_THP-1_Human2.48125600
25RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.42961396
26RUNX_20019798_ChIP-Seq_JUKART_Human2.36946108
27MAF_26560356_Chip-Seq_TH1_Human2.22458779
28SPI1_23547873_ChIP-Seq_NB4_Human2.20459302
29RUNX1_22412390_ChIP-Seq_EML_Mouse2.20105343
30MYC_22102868_ChIP-Seq_BL_Human2.20037554
31KDM2B_26808549_Chip-Seq_SUP-B15_Human2.16895670
32STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.12506592
33TCF7_22412390_ChIP-Seq_EML_Mouse2.08595493
34TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.06745443
35BRD4_27068464_Chip-Seq_AML-cells_Mouse2.06549316
36SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.05161346
37ESR1_17901129_ChIP-ChIP_LIVER_Mouse12.0035341
38E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.97207883
39STAT4_19710469_ChIP-ChIP_TH1__Mouse1.95503794
40HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.95327838
41FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.93960767
42MYB_26560356_Chip-Seq_TH2_Human1.93303985
43TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.91798110
44UTX_26944678_Chip-Seq_JUKART_Human1.89893788
45VDR_24787735_ChIP-Seq_THP-1_Human1.85246127
46KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.85049950
47KDM2B_26808549_Chip-Seq_DND41_Human1.82502543
48MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.82433894
49EGR1_19374776_ChIP-ChIP_THP-1_Human1.77020832
50SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.75819344
51LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.67337177
52LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.65889678
53* MYB_26560356_Chip-Seq_TH1_Human1.64677559
54NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.63462340
55GATA1_22383799_ChIP-Seq_G1ME_Mouse1.63185246
56IKZF1_21737484_ChIP-ChIP_HCT116_Human1.61938958
57FOXA2_19822575_ChIP-Seq_HepG2_Human1.60726571
58MAF_26560356_Chip-Seq_TH2_Human1.58988877
59HTT_18923047_ChIP-ChIP_STHdh_Human1.58473790
60KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.58172910
61CLOCK_20551151_ChIP-Seq_293T_Human1.53390822
62TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.53017327
63ELK3_25401928_ChIP-Seq_HUVEC_Human1.45787143
64GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.44834219
65GATA2_22383799_ChIP-Seq_G1ME_Mouse1.44347396
66CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.44278816
67GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.43462966
68GATA1_22025678_ChIP-Seq_K562_Human1.42717635
69GATA3_27048872_Chip-Seq_THYMUS_Human1.40848737
70HNF4A_19822575_ChIP-Seq_HepG2_Human1.39607478
71THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.33148706
72PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.28524262
73GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.28006173
74CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.24709606
75KDM2B_26808549_Chip-Seq_JURKAT_Human1.22860423
76RXRA_24833708_ChIP-Seq_LIVER_Mouse1.19753249
77PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.19640989
78STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.19638757
79CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.19118257
80SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.18482590
81SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.17793723
82PU_27001747_Chip-Seq_BMDM_Mouse1.17737391
83STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.17646302
84CTCF_27219007_Chip-Seq_ERYTHROID_Human1.16321580
85CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15639985
86ESR1_15608294_ChIP-ChIP_MCF-7_Human1.14406195
87FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.14038755
88PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13896451
89CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09950154
90BCOR_27268052_Chip-Seq_Bcells_Human1.09790354
91VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.09138127
92SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05101075
93* BCL6_27268052_Chip-Seq_Bcells_Human1.04743536
94IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.03562063
95DROSHA_22980978_ChIP-Seq_HELA_Human1.03540570
96ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01709565
97PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01286758
98TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00604414
99NCOR1_26117541_ChIP-Seq_K562_Human0.98452528
100SA1_27219007_Chip-Seq_ERYTHROID_Human0.96205053
101GATA3_26560356_Chip-Seq_TH2_Human0.94753835
102SMC4_20622854_ChIP-Seq_HELA_Human0.94672731
103PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.94303469
104GATA1_19941827_ChIP-Seq_MEL86_Mouse0.92065438
105KDM2B_26808549_Chip-Seq_K562_Human0.91911608
106ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.91061670
107TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.89551344
108TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.88871054
109SOX2_27498859_Chip-Seq_STOMACH_Mouse0.88748169
110SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.88059888
111IRF8_22096565_ChIP-ChIP_GC-B_Human0.87762728
112RACK7_27058665_Chip-Seq_MCF-7_Human0.87212184
113PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.86572057
114AUTS2_25519132_ChIP-Seq_293T-REX_Human0.84733111
115PU.1_20513432_ChIP-Seq_Bcells_Mouse0.83607401
116MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.83310375
117CTCF_21964334_ChIP-Seq_BJAB-B_Human0.82726155
118ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.81388403
119RARG_19884340_ChIP-ChIP_MEFs_Mouse0.79809819
120BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.79232866
121GATA4_25053715_ChIP-Seq_YYC3_Human0.78565057
122ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.76266729
123KAP1_22055183_ChIP-Seq_ESCs_Mouse0.75502993
124SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.75206593
125ZNF263_19887448_ChIP-Seq_K562_Human0.74525840
126RARA_24833708_ChIP-Seq_LIVER_Mouse0.73092568
127SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.73037537
128Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.72768947
129CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.70011133
130AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.66179392
131SALL4_18804426_ChIP-ChIP_XEN_Mouse0.65946621
132RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.65294402
133NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.64185544
134NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.64108671
135NRF2_20460467_ChIP-Seq_MEFs_Mouse0.64108671
136ESR2_21235772_ChIP-Seq_MCF-7_Human0.63500539
137NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.62769757
138RARB_24833708_ChIP-Seq_LIVER_Mouse0.62599089
139RAD21_21589869_ChIP-Seq_MESCs_Mouse0.61117216
140BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.59965090
141NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.58308774
142CEBPB_22108803_ChIP-Seq_LS180_Human0.56705226
143E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.54680205
144EGR1_19032775_ChIP-ChIP_M12_Human0.54371352
145LXR_22292898_ChIP-Seq_THP-1_Human0.53430577
146PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.52514025
147FOXA1_25552417_ChIP-Seq_VCAP_Human0.52055646
148AR_20517297_ChIP-Seq_VCAP_Human0.51008980
149MYC_19915707_ChIP-ChIP_AK7_Human0.50847909
150FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.50477402
151STAT3_1855785_ChIP-Seq_MESCs_Mouse0.48779170
152ESET_19884257_ChIP-Seq_ESCs_Mouse0.48473718
153FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.48415829
154CBP_21632823_ChIP-Seq_H3396_Human0.47766922
155STAT1_17558387_ChIP-Seq_HELA_Human0.47315929
156P53_21459846_ChIP-Seq_SAOS-2_Human0.46257156
157GATA1_19941826_ChIP-Seq_K562_Human0.45767770
158TAF15_26573619_Chip-Seq_HEK293_Human0.45664524
159FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.44453270
160CDX2_20551321_ChIP-Seq_CACO-2_Human0.43585504
161GATA1_19941827_ChIP-Seq_MEL_Mouse0.43411908
162PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.43245891
163* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.43209988
164TAF2_19829295_ChIP-Seq_ESCs_Human0.41322046
165GATA2_19941826_ChIP-Seq_K562_Human0.41132346
166ERG_21242973_ChIP-ChIP_JURKAT_Human0.40683108
167ESR1_21235772_ChIP-Seq_MCF-7_Human0.40414150
168BCAT_22108803_ChIP-Seq_LS180_Human0.40316303
169ESR1_20079471_ChIP-ChIP_T-47D_Human0.39970637
170* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.39795610
171FOXO3_23340844_ChIP-Seq_DLD1_Human0.39542699
172CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.39516750
173* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.39458339
174FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.38973649
175PPAR_26484153_Chip-Seq_NCI-H1993_Human0.38140862
176MYC_27129775_Chip-Seq_CORNEA_Mouse0.37646635
177STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.36528808
178GATA6_25053715_ChIP-Seq_YYC3_Human0.36480082
179LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.36284083
180SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.35279338
181CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.33395084
182FOXH1_21741376_ChIP-Seq_EPCs_Human0.33391543
183* SPI1_26923725_Chip-Seq_HPCs_Mouse0.32579048
184CDX2_22108803_ChIP-Seq_LS180_Human0.32564173
185SOX3_22085726_ChIP-Seq_MUSCLE_Mouse0.32542278
186ERG_20517297_ChIP-Seq_VCAP_Human0.32175006

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.32894898
2MP0005360_urolithiasis7.53544731
3MP0005085_abnormal_gallbladder_physiolo6.45556630
4MP0005365_abnormal_bile_salt6.14930954
5MP0008875_abnormal_xenobiotic_pharmacok5.17913681
6MP0001835_abnormal_antigen_presentation4.62615178
7MP0003806_abnormal_nucleotide_metabolis4.21351859
8MP0003303_peritoneal_inflammation3.94736454
9MP0003252_abnormal_bile_duct3.88795001
10MP0005671_abnormal_response_to3.88577177
11MP0010329_abnormal_lipoprotein_level3.60948755
12MP0009840_abnormal_foam_cell3.35561255
13MP0005083_abnormal_biliary_tract3.12646344
14MP0003195_calcinosis2.82074054
15MP0001790_abnormal_immune_system2.77765353
16MP0005387_immune_system_phenotype2.77765353
17MP0005332_abnormal_amino_acid2.75027163
18MP0001800_abnormal_humoral_immune2.70315201
19MP0002419_abnormal_innate_immunity2.68421692
20MP0005000_abnormal_immune_tolerance2.60987933
21MP0003300_gastrointestinal_ulcer2.60985541
22MP0005025_abnormal_response_to2.59623932
23MP0001666_abnormal_nutrient_absorption2.57020887
24MP0003191_abnormal_cellular_cholesterol2.43911140
25MP0003172_abnormal_lysosome_physiology2.42195876
26MP0000685_abnormal_immune_system2.40643534
27MP0002723_abnormal_immune_serum2.40338714
28MP0002452_abnormal_antigen_presenting2.28481793
29MP0002420_abnormal_adaptive_immunity2.22517315
30MP0001819_abnormal_immune_cell2.21960279
31MP0009785_altered_susceptibility_to2.20977469
32MP0000609_abnormal_liver_physiology2.16946254
33MP0004019_abnormal_vitamin_homeostasis2.14035499
34MP0002118_abnormal_lipid_homeostasis2.10288895
35MP0010155_abnormal_intestine_physiology2.08571887
36MP0001533_abnormal_skeleton_physiology2.04793158
37MP0002138_abnormal_hepatobiliary_system1.97580323
38MP0008260_abnormal_autophagy1.95781916
39MP0003868_abnormal_feces_composition1.92241204
40MP0002148_abnormal_hypersensitivity_rea1.91105000
41MP0002398_abnormal_bone_marrow1.89608794
42MP0003866_abnormal_defecation1.85721018
43MP0009333_abnormal_splenocyte_physiolog1.82575759
44MP0005319_abnormal_enzyme/_coenzyme1.82391733
45MP0003828_pulmonary_edema1.80760795
46MP0003763_abnormal_thymus_physiology1.77942291
47MP0000716_abnormal_immune_system1.76863088
48MP0002405_respiratory_system_inflammati1.70903881
49MP0004510_myositis1.70334433
50MP0001764_abnormal_homeostasis1.65107115
51MP0009278_abnormal_bone_marrow1.61536711
52MP0003878_abnormal_ear_physiology1.59946736
53MP0005377_hearing/vestibular/ear_phenot1.59946736
54MP0009697_abnormal_copulation1.59855391
55MP0008004_abnormal_stomach_pH1.56634919
56MP0005584_abnormal_enzyme/coenzyme_acti1.56316668
57MP0000465_gastrointestinal_hemorrhage1.54173412
58MP0002722_abnormal_immune_system1.52661915
59MP0000689_abnormal_spleen_morphology1.49644137
60MP0004947_skin_inflammation1.49576169
61MP0002166_altered_tumor_susceptibility1.48831229
62MP0002429_abnormal_blood_cell1.47321187
63MP0005451_abnormal_body_composition1.44471708
64MP0002998_abnormal_bone_remodeling1.44177762
65MP0001851_eye_inflammation1.40025739
66MP0003011_delayed_dark_adaptation1.38500937
67MP0001545_abnormal_hematopoietic_system1.36664147
68MP0005397_hematopoietic_system_phenotyp1.36664147
69MP0001348_abnormal_lacrimal_gland1.32684267
70MP0000703_abnormal_thymus_morphology1.30961853
71MP0003656_abnormal_erythrocyte_physiolo1.29486659
72MP0003186_abnormal_redox_activity1.24458977
73MP0002102_abnormal_ear_morphology1.24185914
74MP0005310_abnormal_salivary_gland1.22389876
75MP0009643_abnormal_urine_homeostasis1.21631363
76MP0000598_abnormal_liver_morphology1.17933396
77MP0000858_altered_metastatic_potential1.17525458
78MP0003705_abnormal_hypodermis_morpholog1.17246204
79MP0005647_abnormal_sex_gland1.13582756
80MP0000604_amyloidosis1.13201338
81MP0002396_abnormal_hematopoietic_system1.09461935
82MP0009764_decreased_sensitivity_to1.07567100
83MP0002254_reproductive_system_inflammat1.06199567
84MP0009763_increased_sensitivity_to1.04800889
85MP0010368_abnormal_lymphatic_system1.02049063
86MP0005409_darkened_coat_color1.01537314
87MP0002653_abnormal_ependyma_morphology1.00612564
88MP0003879_abnormal_hair_cell0.97873690
89MP0001663_abnormal_digestive_system0.92859389
90MP0005636_abnormal_mineral_homeostasis0.91275586
91MP0008469_abnormal_protein_level0.90242189
92MP0003091_abnormal_cell_migration0.89542087
93MP0003183_abnormal_peptide_metabolism0.88561042
94MP0000343_altered_response_to0.87428310
95MP0009642_abnormal_blood_homeostasis0.87421053
96MP0005076_abnormal_cell_differentiation0.87239187
97MP0005390_skeleton_phenotype0.87166746
98MP0001986_abnormal_taste_sensitivity0.85497521
99MP0002006_tumorigenesis0.83833985
100MP0005408_hypopigmentation0.83486448
101MP0006036_abnormal_mitochondrial_physio0.79809278
102MP0009765_abnormal_xenobiotic_induced0.79289619
103MP0005376_homeostasis/metabolism_phenot0.78868553
104MP0000490_abnormal_crypts_of0.78426678
105MP0002876_abnormal_thyroid_physiology0.77492286
106MP0002078_abnormal_glucose_homeostasis0.77190913
107MP0005670_abnormal_white_adipose0.77075098
108MP0000015_abnormal_ear_pigmentation0.73022571
109MP0002971_abnormal_brown_adipose0.72111457
110MP0005084_abnormal_gallbladder_morpholo0.72015772
111MP0003045_fibrosis0.71726700
112MP0005220_abnormal_exocrine_pancreas0.71328458
113MP0003690_abnormal_glial_cell0.70392118
114MP0001661_extended_life_span0.69669535
115MP0004130_abnormal_muscle_cell0.68686156
116MP0001958_emphysema0.68641758
117MP0005334_abnormal_fat_pad0.68220637
118MP0005535_abnormal_body_temperature0.65820823
119MP0009053_abnormal_anal_canal0.65710237
120MP0001873_stomach_inflammation0.65224900
121MP0003329_amyloid_beta_deposits0.64672332
122MP0001849_ear_inflammation0.63257303
123MP0003448_altered_tumor_morphology0.63042357
124MP0005266_abnormal_metabolism0.62448779
125MP0000639_abnormal_adrenal_gland0.61869969
126MP0004808_abnormal_hematopoietic_stem0.60018870
127MP0003795_abnormal_bone_structure0.59923642
128MP0005381_digestive/alimentary_phenotyp0.59451584
129MP0005464_abnormal_platelet_physiology0.57790138
130MP0002933_joint_inflammation0.57471668
131MP0001756_abnormal_urination0.57394585
132MP0005448_abnormal_energy_balance0.55709892
133MP0006035_abnormal_mitochondrial_morpho0.54877813
134MP0002822_catalepsy0.48941435
135MP0005395_other_phenotype0.48758776
136MP0003638_abnormal_response/metabolism_0.47513987
137MP0003436_decreased_susceptibility_to0.47016583
138MP0008874_decreased_physiological_sensi0.46575272
139MP0003718_maternal_effect0.45456991
140MP0003724_increased_susceptibility_to0.45006044
141MP0008873_increased_physiological_sensi0.44795281
142MP0002136_abnormal_kidney_physiology0.44737616
143MP0003075_altered_response_to0.42945674
144MP0002928_abnormal_bile_duct0.42869183
145MP0004782_abnormal_surfactant_physiolog0.41115059
146MP0002837_dystrophic_cardiac_calcinosis0.40894892
147MP0003953_abnormal_hormone_level0.39751532
148MP0005248_abnormal_Harderian_gland0.39477546
149MP0005166_decreased_susceptibility_to0.38279814
150MP0008872_abnormal_physiological_respon0.37550481
151MP0009672_abnormal_birth_weight0.35565199
152MP0005666_abnormal_adipose_tissue0.34954710
153MP0000249_abnormal_blood_vessel0.34395321
154MP0006082_CNS_inflammation0.34238824
155MP0004381_abnormal_hair_follicle0.34038485
156MP0004883_abnormal_blood_vessel0.33530959
157MP0000579_abnormal_nail_morphology0.33394159
158MP0001243_abnormal_dermal_layer0.32552688
159MP0009115_abnormal_fat_cell0.32214338
160MP0000230_abnormal_systemic_arterial0.30930240
161MP0001853_heart_inflammation0.30837365
162MP0002168_other_aberrant_phenotype0.30400122
163MP0009384_cardiac_valve_regurgitation0.30334650
164MP0002970_abnormal_white_adipose0.29887949
165MP0002796_impaired_skin_barrier0.29426423
166MP0001845_abnormal_inflammatory_respons0.29110081
167MP0001881_abnormal_mammary_gland0.27562922
168MP0005164_abnormal_response_to0.26289956
169MP0002090_abnormal_vision0.24635658
170MP0002132_abnormal_respiratory_system0.23910692
171MP0005058_abnormal_lysosome_morphology0.23339332

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.56045346
2Abnormality of aromatic amino acid family metabolism (HP:0004338)7.41302978
3Intrahepatic cholestasis (HP:0001406)7.30163164
4Prolonged partial thromboplastin time (HP:0003645)6.72731287
5Abnormality of monocarboxylic acid metabolism (HP:0010996)6.69141719
6Hypobetalipoproteinemia (HP:0003563)6.47091651
7Xanthomatosis (HP:0000991)6.29284169
8Hyperlipoproteinemia (HP:0010980)5.65962038
9Complement deficiency (HP:0004431)5.42173593
10Eczematoid dermatitis (HP:0000976)4.93015783
11Joint hemorrhage (HP:0005261)4.92795804
12Prolonged bleeding time (HP:0003010)4.89683426
13Hypolipoproteinemia (HP:0010981)4.85036784
14Recurrent cutaneous fungal infections (HP:0011370)4.79624706
15Chronic mucocutaneous candidiasis (HP:0002728)4.79624706
16Abnormality of macrophages (HP:0004311)4.69619151
17Recurrent abscess formation (HP:0002722)4.61881099
18Hyperammonemia (HP:0001987)4.59040829
19Abnormality of the common coagulation pathway (HP:0010990)4.56762359
20Myositis (HP:0100614)4.54436887
21Recurrent bacterial skin infections (HP:0005406)4.53979627
22Epidermoid cyst (HP:0200040)4.51756297
23Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.43983738
24Recurrent fungal infections (HP:0002841)4.40822220
25Hyperglycinemia (HP:0002154)4.37068465
26Abnormal delayed hypersensitivity skin test (HP:0002963)4.36997905
27Abnormality of methionine metabolism (HP:0010901)4.32448727
28Hypoalphalipoproteinemia (HP:0003233)4.26563621
29Abnormality of sulfur amino acid metabolism (HP:0004339)4.25096267
30Ketosis (HP:0001946)4.22598553
31Purpura (HP:0000979)4.17727882
32Retrobulbar optic neuritis (HP:0100654)4.15610980
33Optic neuritis (HP:0100653)4.15610980
34Abnormality of aspartate family amino acid metabolism (HP:0010899)4.14530392
35Orchitis (HP:0100796)4.13160529
36Abnormality of glutamine family amino acid metabolism (HP:0010902)4.11620924
37Fat malabsorption (HP:0002630)4.09825976
38Recurrent skin infections (HP:0001581)4.00460947
39Abnormality of complement system (HP:0005339)3.96740568
40Colitis (HP:0002583)3.94631379
41Meningitis (HP:0001287)3.87030136
42Abnormality of pyrimidine metabolism (HP:0004353)3.86959142
43Abnormal platelet volume (HP:0011876)3.86645814
44Petechiae (HP:0000967)3.85852406
45Abnormality of glycine metabolism (HP:0010895)3.85052019
46Abnormality of serine family amino acid metabolism (HP:0010894)3.85052019
47Hyperglycinuria (HP:0003108)3.84963740
48Encephalitis (HP:0002383)3.84535511
49Spontaneous hematomas (HP:0007420)3.84050348
50Abnormality of the intrinsic pathway (HP:0010989)3.83543761
51Hypoglycemic coma (HP:0001325)3.82216188
52Epistaxis (HP:0000421)3.77551401
53Recurrent viral infections (HP:0004429)3.76470792
54Hypercholesterolemia (HP:0003124)3.67503228
55Conjugated hyperbilirubinemia (HP:0002908)3.66880072
56Gastrointestinal inflammation (HP:0004386)3.63730556
57Inflammation of the large intestine (HP:0002037)3.60474116
58Elevated erythrocyte sedimentation rate (HP:0003565)3.55633171
59Panhypogammaglobulinemia (HP:0003139)3.54184914
60Increased IgE level (HP:0003212)3.48324043
61Increased mean platelet volume (HP:0011877)3.36773233
62Hyperbilirubinemia (HP:0002904)3.36539422
63Agammaglobulinemia (HP:0004432)3.32934599
64Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.32662261
65Gastrointestinal infarctions (HP:0005244)3.32141113
66Chronic obstructive pulmonary disease (HP:0006510)3.30023606
67Obstructive lung disease (HP:0006536)3.30023606
68Abnormality of fatty-acid metabolism (HP:0004359)3.29132988
69Spontaneous abortion (HP:0005268)3.14477415
70Pulmonary infiltrates (HP:0002113)3.08688941
71Steatorrhea (HP:0002570)3.08464297
72Delayed CNS myelination (HP:0002188)3.06583734
73Abnormality of nucleobase metabolism (HP:0010932)3.04247484
74Keratoconjunctivitis sicca (HP:0001097)3.04037291
75Abnormality of serum amino acid levels (HP:0003112)3.03632089
76Chest pain (HP:0100749)3.02597037
77Hepatocellular carcinoma (HP:0001402)2.98909644
78Ketoacidosis (HP:0001993)2.97602456
79Vasculitis (HP:0002633)2.97398962
80Hypochromic microcytic anemia (HP:0004840)2.96197598
81Hemoptysis (HP:0002105)2.95895485
82Myocardial infarction (HP:0001658)2.95299818
83Stomatitis (HP:0010280)2.95200132
84Mediastinal lymphadenopathy (HP:0100721)2.91877053
85Gingivitis (HP:0000230)2.85049244
86Dysostosis multiplex (HP:0000943)2.84319058
87Systemic lupus erythematosus (HP:0002725)2.79891576
88Arterial thrombosis (HP:0004420)2.79275954
89Skin nodule (HP:0200036)2.78842737
90Thrombocytosis (HP:0001894)2.78335489
91Keratoconjunctivitis (HP:0001096)2.77933658
92Metabolic acidosis (HP:0001942)2.73498658
93Urticaria (HP:0001025)2.67974961
94Glomerulonephritis (HP:0000099)2.63832658
95Abnormality of purine metabolism (HP:0004352)2.62891655
96Acanthocytosis (HP:0001927)2.59133588
97Vascular calcification (HP:0004934)2.59040829
98Lethargy (HP:0001254)2.57383931
99Cellulitis (HP:0100658)2.54159370
100Loss of speech (HP:0002371)2.53532276
101Leukocytosis (HP:0001974)2.53366068
102Abnormality of dicarboxylic acid metabolism (HP:0010995)2.53181849
103Dicarboxylic aciduria (HP:0003215)2.53181849
104Abnormal gallbladder morphology (HP:0012437)2.48364723
105Episodic fever (HP:0001954)2.47288416
106Increased cerebral lipofuscin (HP:0011813)2.46671083
107Viral hepatitis (HP:0006562)2.45732564
108Hypoglycemic seizures (HP:0002173)2.45162085
109Mitral stenosis (HP:0001718)2.45039715
110Spastic diplegia (HP:0001264)2.44488770
111T lymphocytopenia (HP:0005403)2.42523271
112Cholelithiasis (HP:0001081)2.41851649
113Cerebral edema (HP:0002181)2.39106275
114Amyloidosis (HP:0011034)2.38072944
115Joint swelling (HP:0001386)2.37984461
116Gout (HP:0001997)2.37929963
117Abnormality of T cells (HP:0002843)2.37661146
118Irritability (HP:0000737)2.34839662
119Neonatal onset (HP:0003623)2.33932828
120Abnormal gallbladder physiology (HP:0012438)2.33482168
121Cholecystitis (HP:0001082)2.33482168
122Recurrent gram-negative bacterial infections (HP:0005420)2.32956919
123Mucopolysacchariduria (HP:0008155)2.31940931
124Urinary glycosaminoglycan excretion (HP:0003541)2.31940931
125Gingival bleeding (HP:0000225)2.30849412
126Cardiovascular calcification (HP:0011915)2.29750267
127Abnormality of the endocardium (HP:0004306)2.26993791
128Hepatosplenomegaly (HP:0001433)2.26467340
129Anorexia (HP:0002039)2.25928488
130Abnormal platelet function (HP:0011869)2.25597477
131Impaired platelet aggregation (HP:0003540)2.25597477
132Esophageal varix (HP:0002040)2.24890625
133Abnormality of polysaccharide metabolism (HP:0011012)2.24773704
134Abnormality of glycosaminoglycan metabolism (HP:0004371)2.24773704
135Abnormality of mucopolysaccharide metabolism (HP:0011020)2.24773704
136Malnutrition (HP:0004395)2.22995445
137Increased IgM level (HP:0003496)2.21734602
138Menorrhagia (HP:0000132)2.21491097
139Abnormality of T cell number (HP:0011839)2.20698365
140Abnormality of T cell physiology (HP:0011840)2.17612003
141Vertigo (HP:0002321)2.17564858
142Thrombophlebitis (HP:0004418)2.17218518
143Granulocytopenia (HP:0001913)2.16590931
144Increased serum ferritin (HP:0003281)2.15495899
145Osteomyelitis (HP:0002754)2.14251072
146Pancreatitis (HP:0001733)2.11598422
147Abnormality of the pleura (HP:0002103)2.11277861
148Late onset (HP:0003584)2.10921926
149Sensorimotor neuropathy (HP:0007141)2.10602019
150Brushfield spots (HP:0001088)2.09429776
151Enlarged kidneys (HP:0000105)2.08452987
152Gangrene (HP:0100758)2.07506918
153Poikilocytosis (HP:0004447)2.06442569
154Vomiting (HP:0002013)2.04182561
155Peritonitis (HP:0002586)2.03078306
156Interstitial pulmonary disease (HP:0006530)2.02025661
157Hemorrhage of the eye (HP:0011885)2.01489481
158Opisthotonus (HP:0002179)2.00903970
159Abnormality of the gallbladder (HP:0005264)2.00851415
160Hypertensive crisis (HP:0100735)2.00180006
161Hypergammaglobulinemia (HP:0010702)1.99738688
162Hyperinsulinemic hypoglycemia (HP:0000825)1.98797885
163Generalized aminoaciduria (HP:0002909)1.97817163
164Polyneuropathy (HP:0001271)1.96385896
165Cheilitis (HP:0100825)1.96358873
166Abnormality of iron homeostasis (HP:0011031)1.93725532
167Rickets (HP:0002748)1.92723086
168Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.91484236
169Abnormality of transition element cation homeostasis (HP:0011030)1.89593163
170Skin ulcer (HP:0200042)1.89555132
171Abnormal cartilage morphology (HP:0002763)1.85886702
172Abnormality of the peritoneum (HP:0002585)1.85845891
173Acrocyanosis (HP:0001063)1.85395151
174Nephritis (HP:0000123)1.85100464
175Hypophosphatemic rickets (HP:0004912)1.84708650
176Chronic otitis media (HP:0000389)1.84570384
177Sepsis (HP:0100806)1.84442140
178Xerostomia (HP:0000217)1.83084904
179Keratitis (HP:0000491)1.82857323
180Pustule (HP:0200039)1.82466859
181Renal cortical cysts (HP:0000803)1.82309312
182Arthralgia (HP:0002829)1.81713764
183Hydroxyprolinuria (HP:0003080)1.81276569
184Abnormality of proline metabolism (HP:0010907)1.81276569
185Elevated hepatic transaminases (HP:0002910)1.81109857
186Status epilepticus (HP:0002133)1.79587021
187Alkalosis (HP:0001948)1.79370662
188Abnormal enzyme/coenzyme activity (HP:0012379)1.78651437
189Pulmonary embolism (HP:0002204)1.75698085
190Reticulocytosis (HP:0001923)1.72726679

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.19613314
2RIPK45.01270590
3FGFR44.66071629
4SIK14.62521119
5ERN14.34821817
6BLK3.77103588
7TAOK33.05593206
8INSRR2.96854495
9ERBB42.86671234
10JAK32.71598578
11PRPF4B2.59085277
12MAP4K12.51832632
13TNK22.45177600
14MAP2K42.37097311
15PKN22.31847827
16FES2.11356060
17MST1R2.08221550
18ZAP701.97883948
19FLT31.93523890
20MAPK111.90925899
21MATK1.89975166
22CDC42BPA1.79605755
23TYK21.78976334
24TRIB31.77572824
25PIK3CG1.76171073
26KIT1.67788533
27FGR1.67286745
28SYK1.65738421
29DAPK21.62378300
30BTK1.58819599
31LATS11.52999184
32PTK61.48308791
33HCK1.47060753
34ABL21.46504470
35KDR1.46045475
36IRAK41.41996322
37FGFR21.40207802
38NEK91.33944284
39FRK1.33556447
40SMG11.27387607
41JAK21.26742728
42NME11.25642826
43LCK1.21502855
44SIK21.17802268
45MAP3K71.17707605
46LYN1.14855055
47PINK11.13376568
48GRK61.11834842
49PRKAA21.11004094
50TBK11.08169322
51MAP2K31.07755440
52TEC1.07417051
53JAK11.05714541
54MAP3K101.05334757
55MAPK41.02969591
56ERBB21.02464251
57BRD41.02460877
58MAP3K140.96566136
59IKBKB0.95182795
60TAOK10.94252125
61MARK20.94149995
62PRKD20.93123660
63TXK0.92975625
64PRKCZ0.91825599
65EPHB10.90254088
66SIK30.89784201
67MAPK120.86515797
68MET0.82457647
69TIE10.82263644
70EPHA30.82258291
71MAP3K30.81052513
72CDK60.80868861
73KSR20.77956113
74PRKACG0.77614585
75YES10.76842622
76STK38L0.76486425
77MAP3K110.76274722
78CDK120.76023241
79FYN0.73371589
80TGFBR20.73353882
81CSK0.72804774
82MAPK150.72774210
83DYRK1B0.70284815
84CAMK2G0.69864517
85CAMK1D0.69857235
86GSK3A0.65446359
87MARK30.65128464
88MAP2K60.65055656
89RIPK10.64795002
90MAP3K20.64752590
91PRKAA10.64226511
92ITK0.63562445
93SGK30.61520030
94FGFR30.60028148
95CSF1R0.59616559
96MAPK70.58583537
97IKBKE0.57688348
98EPHA40.52756535
99PTK20.52740228
100IRAK30.51869514
101CAMKK10.51796386
102CSNK1G10.51634859
103PRKCQ0.51614392
104PDPK10.50200677
105GRK10.46814784
106LRRK20.46506769
107RPS6KL10.46405968
108RPS6KC10.46405968
109BMPR20.45706728
110RET0.45010068
111IGF1R0.44872107
112SGK20.43894892
113TAOK20.43567968
114STK100.42775859
115MAP3K130.42392660
116PKN10.42119090
117CDK40.42034053
118PRKCG0.41664070
119MAP3K50.41250533
120PTK2B0.39780811
121MAP2K10.39005946
122CDK190.38957061
123RPS6KA60.38428239
124PRKD10.37822775
125ICK0.37361065
126STK240.37029848
127MAPKAPK20.36522193
128MAP3K60.36399817
129STK380.35548038
130EGFR0.34296348
131CAMK40.34080326
132PDGFRB0.33797538
133HIPK20.33317271
134PDK10.32928046
135MTOR0.32907208
136CSNK1G20.32373815
137RPS6KA20.32325312
138PBK0.30800515
139CSNK1G30.29980194
140CAMKK20.29902709
141SGK4940.29639969
142SGK2230.29639969
143PRKCA0.26063640
144MAP3K10.23355168
145IRAK10.22673454
146CAMK1G0.22065019
147LATS20.21465774
148CSNK1A1L0.21060549
149ABL10.21029712
150PIK3CA0.20636071
151IRAK20.20385407
152BMX0.20005768
153PAK30.19189651

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.53244362
2Nitrogen metabolism_Homo sapiens_hsa009103.62734139
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.38769009
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.36609542
5Leishmaniasis_Homo sapiens_hsa051403.23307738
6Arginine biosynthesis_Homo sapiens_hsa002203.08204250
7Complement and coagulation cascades_Homo sapiens_hsa046102.85779072
8Allograft rejection_Homo sapiens_hsa053302.77248490
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.74439682
10Graft-versus-host disease_Homo sapiens_hsa053322.73835208
11Tryptophan metabolism_Homo sapiens_hsa003802.67353086
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.62311152
13Osteoclast differentiation_Homo sapiens_hsa043802.61312245
14Autoimmune thyroid disease_Homo sapiens_hsa053202.57588229
15Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.52788842
16Fatty acid degradation_Homo sapiens_hsa000712.47726998
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.36309306
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.32000680
19Pentose and glucuronate interconversions_Homo sapiens_hsa000402.25100972
20Asthma_Homo sapiens_hsa053102.16637819
21Butanoate metabolism_Homo sapiens_hsa006502.14615734
22Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.13005791
23Tuberculosis_Homo sapiens_hsa051522.07278878
24Type I diabetes mellitus_Homo sapiens_hsa049402.06891964
25Peroxisome_Homo sapiens_hsa041462.06836073
26Hematopoietic cell lineage_Homo sapiens_hsa046402.01641555
27Chemical carcinogenesis_Homo sapiens_hsa052041.95711910
28Steroid hormone biosynthesis_Homo sapiens_hsa001401.93121333
29Other glycan degradation_Homo sapiens_hsa005111.92686296
30Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.92676493
31Intestinal immune network for IgA production_Homo sapiens_hsa046721.92407629
32Propanoate metabolism_Homo sapiens_hsa006401.91067470
33Histidine metabolism_Homo sapiens_hsa003401.90720815
34Antigen processing and presentation_Homo sapiens_hsa046121.89081026
35B cell receptor signaling pathway_Homo sapiens_hsa046621.88377558
36PPAR signaling pathway_Homo sapiens_hsa033201.87117940
37Primary immunodeficiency_Homo sapiens_hsa053401.86211319
38Staphylococcus aureus infection_Homo sapiens_hsa051501.85836723
39Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.82440845
40Fatty acid metabolism_Homo sapiens_hsa012121.81239396
41Drug metabolism - other enzymes_Homo sapiens_hsa009831.77862931
42Toxoplasmosis_Homo sapiens_hsa051451.76765216
43Viral myocarditis_Homo sapiens_hsa054161.74774582
44Caffeine metabolism_Homo sapiens_hsa002321.74436699
45Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.74208157
46beta-Alanine metabolism_Homo sapiens_hsa004101.70955231
47Toll-like receptor signaling pathway_Homo sapiens_hsa046201.69375072
48NOD-like receptor signaling pathway_Homo sapiens_hsa046211.69327950
49Retinol metabolism_Homo sapiens_hsa008301.68670599
50Platelet activation_Homo sapiens_hsa046111.67042463
51Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.65683646
52Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.62116039
53Measles_Homo sapiens_hsa051621.61199185
54Selenocompound metabolism_Homo sapiens_hsa004501.57408067
55Phenylalanine metabolism_Homo sapiens_hsa003601.56446414
56Chemokine signaling pathway_Homo sapiens_hsa040621.53452591
57Influenza A_Homo sapiens_hsa051641.53209670
582-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.50196986
59Bile secretion_Homo sapiens_hsa049761.50040297
60Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.49618016
61Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.49545993
62Tyrosine metabolism_Homo sapiens_hsa003501.42529830
63Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.40570696
64Notch signaling pathway_Homo sapiens_hsa043301.37177991
65Pyruvate metabolism_Homo sapiens_hsa006201.34845303
66Herpes simplex infection_Homo sapiens_hsa051681.33987428
67Fatty acid elongation_Homo sapiens_hsa000621.33422444
68Sulfur metabolism_Homo sapiens_hsa009201.32960702
69T cell receptor signaling pathway_Homo sapiens_hsa046601.32770082
70Cysteine and methionine metabolism_Homo sapiens_hsa002701.31155968
71NF-kappa B signaling pathway_Homo sapiens_hsa040641.28869040
72Jak-STAT signaling pathway_Homo sapiens_hsa046301.28272777
73Starch and sucrose metabolism_Homo sapiens_hsa005001.27416974
74Steroid biosynthesis_Homo sapiens_hsa001001.22124508
75ABC transporters_Homo sapiens_hsa020101.20837308
76Folate biosynthesis_Homo sapiens_hsa007901.20442413
77Biosynthesis of amino acids_Homo sapiens_hsa012301.19531052
78Acute myeloid leukemia_Homo sapiens_hsa052211.17988685
79Phagosome_Homo sapiens_hsa041451.17537966
80Fat digestion and absorption_Homo sapiens_hsa049751.16242104
81Malaria_Homo sapiens_hsa051441.12909072
82Carbon metabolism_Homo sapiens_hsa012001.11348250
83Legionellosis_Homo sapiens_hsa051341.10392901
84Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.03804051
85Non-small cell lung cancer_Homo sapiens_hsa052231.02798709
86RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.02495778
87Pancreatic cancer_Homo sapiens_hsa052121.01249765
88Cyanoamino acid metabolism_Homo sapiens_hsa004600.99886678
89Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.99408823
90Rheumatoid arthritis_Homo sapiens_hsa053230.99333949
91Maturity onset diabetes of the young_Homo sapiens_hsa049500.98514713
92Leukocyte transendothelial migration_Homo sapiens_hsa046700.95964425
93Arginine and proline metabolism_Homo sapiens_hsa003300.95366012
94TNF signaling pathway_Homo sapiens_hsa046680.94524882
95Sulfur relay system_Homo sapiens_hsa041220.93364305
96Vitamin B6 metabolism_Homo sapiens_hsa007500.88657951
97Lysosome_Homo sapiens_hsa041420.87940217
98Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.87753802
99Phospholipase D signaling pathway_Homo sapiens_hsa040720.87015939
100Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.86508311
101VEGF signaling pathway_Homo sapiens_hsa043700.86291300
102Vitamin digestion and absorption_Homo sapiens_hsa049770.85917171
103Hepatitis B_Homo sapiens_hsa051610.84304368
104Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.84275362
105Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.82552855
106Lysine degradation_Homo sapiens_hsa003100.80436521
107One carbon pool by folate_Homo sapiens_hsa006700.75790455
108Choline metabolism in cancer_Homo sapiens_hsa052310.75626497
109Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.75175380
110Chronic myeloid leukemia_Homo sapiens_hsa052200.74264981
111GnRH signaling pathway_Homo sapiens_hsa049120.71506922
112Salmonella infection_Homo sapiens_hsa051320.70901115
113Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68857273
114Prolactin signaling pathway_Homo sapiens_hsa049170.66427074
115Glycerolipid metabolism_Homo sapiens_hsa005610.66127542
116Neurotrophin signaling pathway_Homo sapiens_hsa047220.65744247
117SNARE interactions in vesicular transport_Homo sapiens_hsa041300.65476208
118Shigellosis_Homo sapiens_hsa051310.64593766
119Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.64268226
120Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.62905414
121Glutathione metabolism_Homo sapiens_hsa004800.62871129
122Endocytosis_Homo sapiens_hsa041440.62849210
123Apoptosis_Homo sapiens_hsa042100.58145385
124HTLV-I infection_Homo sapiens_hsa051660.58093664
125AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.57780761
126Pentose phosphate pathway_Homo sapiens_hsa000300.56543648
127Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.56310026
128Phosphatidylinositol signaling system_Homo sapiens_hsa040700.55241559
129Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.54842572
130Epstein-Barr virus infection_Homo sapiens_hsa051690.54066439
131Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.53401350
132Fatty acid biosynthesis_Homo sapiens_hsa000610.53278550
133Sphingolipid signaling pathway_Homo sapiens_hsa040710.51997866
134Transcriptional misregulation in cancer_Homo sapiens_hsa052020.50749469
135Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.45754427
136Metabolic pathways_Homo sapiens_hsa011000.45242188
137Viral carcinogenesis_Homo sapiens_hsa052030.42188494
138Renal cell carcinoma_Homo sapiens_hsa052110.41391239
139Type II diabetes mellitus_Homo sapiens_hsa049300.41097070
140Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.40237081
141Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.39312377
142Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.38565889
143MAPK signaling pathway_Homo sapiens_hsa040100.38529745
144Inositol phosphate metabolism_Homo sapiens_hsa005620.38347667
145Vascular smooth muscle contraction_Homo sapiens_hsa042700.38018824
146FoxO signaling pathway_Homo sapiens_hsa040680.36589103
147Prion diseases_Homo sapiens_hsa050200.35402051
148Endometrial cancer_Homo sapiens_hsa052130.33834899
149Colorectal cancer_Homo sapiens_hsa052100.31515112
150Rap1 signaling pathway_Homo sapiens_hsa040150.29681631
151mTOR signaling pathway_Homo sapiens_hsa041500.29236323
152Dorso-ventral axis formation_Homo sapiens_hsa043200.29044424
153HIF-1 signaling pathway_Homo sapiens_hsa040660.29017566
154alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.24920017
155Galactose metabolism_Homo sapiens_hsa000520.24076722
156Insulin resistance_Homo sapiens_hsa049310.23175229
157Fructose and mannose metabolism_Homo sapiens_hsa000510.22351132
158Adipocytokine signaling pathway_Homo sapiens_hsa049200.21869294
159Linoleic acid metabolism_Homo sapiens_hsa005910.21556735
160Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.19894740
161Glycerophospholipid metabolism_Homo sapiens_hsa005640.14963680
162Glucagon signaling pathway_Homo sapiens_hsa049220.09612508
163AMPK signaling pathway_Homo sapiens_hsa041520.01549697
164Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2488065
165Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2416985
166Amoebiasis_Homo sapiens_hsa05146-0.2408952
167Pertussis_Homo sapiens_hsa05133-0.2393344
168Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.2247014
169Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.2034228
170Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1954893
171Renin-angiotensin system_Homo sapiens_hsa04614-0.1781786
172Hepatitis C_Homo sapiens_hsa05160-0.1781211
173Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1721329
174Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1625557
175Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1600786
176Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1574711
177Regulation of autophagy_Homo sapiens_hsa04140-0.1507989
178African trypanosomiasis_Homo sapiens_hsa05143-0.1322155
179Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1308100
180Insulin signaling pathway_Homo sapiens_hsa04910-0.1050201
181Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0935801
182Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0900075
183Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0723757
184Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0498272

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