ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	eosinophil chemotaxis (GO:0048245)	9.55811399
2	eosinophil migration (GO:0072677)	8.55398711
3	synaptic vesicle endocytosis (GO:0048488)	6.14131686
4	synaptic vesicle maturation (GO:0016188)	5.93169273
5	synaptic vesicle exocytosis (GO:0016079)	5.55832998
6	protein localization to synapse (GO:0035418)	5.09941181
7	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	5.08325692
8	regulation of macrophage chemotaxis (GO:0010758)	4.99301000
9	cellular response to ethanol (GO:0071361)	4.96522016
10	cellular potassium ion homeostasis (GO:0030007)	4.87187538
11	regulation of synaptic vesicle exocytosis (GO:2000300)	4.86635811
12	detection of temperature stimulus involved in sensory perception of pain (GO:0050965)	4.69933696
13	detection of temperature stimulus involved in sensory perception (GO:0050961)	4.69933696
14	positive regulation of guanylate cyclase activity (GO:0031284)	4.65280240
15	gamma-aminobutyric acid transport (GO:0015812)	4.56144893
16	sodium ion export (GO:0071436)	4.50122501
17	synaptic vesicle docking involved in exocytosis (GO:0016081)	4.47654199
18	glutamate secretion (GO:0014047)	4.43134313
19	positive regulation of cAMP-mediated signaling (GO:0043950)	4.40058837
20	ionotropic glutamate receptor signaling pathway (GO:0035235)	4.27240315
21	negative regulation of synaptic transmission, GABAergic (GO:0032229)	4.22833144
22	regulation of guanylate cyclase activity (GO:0031282)	4.18397329
23	regulation of synaptic vesicle transport (GO:1902803)	4.17956714
24	regulation of short-term neuronal synaptic plasticity (GO:0048172)	4.16827157
25	neurotransmitter secretion (GO:0007269)	4.05988899
26	retinal cone cell development (GO:0046549)	3.97198718
27	membrane depolarization during action potential (GO:0086010)	3.96792349
28	neuronal action potential propagation (GO:0019227)	3.86447244
29	regulation of mononuclear cell migration (GO:0071675)	3.82952848
30	receptor guanylyl cyclase signaling pathway (GO:0007168)	3.82519934
31	layer formation in cerebral cortex (GO:0021819)	3.75573861
32	regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)	3.70380380
33	establishment of synaptic vesicle localization (GO:0097480)	3.65920451
34	synaptic vesicle transport (GO:0048489)	3.65920451
35	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	3.64723605
36	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	3.63641654
37	negative regulation of metanephros development (GO:0072217)	3.55852149
38	detection of temperature stimulus (GO:0016048)	3.55014060
39	positive regulation of synapse maturation (GO:0090129)	3.52401655
40	adhesion of symbiont to host cell (GO:0044650)	3.47848916
41	virion attachment to host cell (GO:0019062)	3.47848916
42	cerebellar granule cell differentiation (GO:0021707)	3.44788346
43	positive regulation of male gonad development (GO:2000020)	3.44355931
44	synaptic transmission, glutamatergic (GO:0035249)	3.43239018
45	cell communication by electrical coupling involved in cardiac conduction (GO:0086064)	3.38793041
46	diaphragm development (GO:0060539)	3.36975483
47	mitochondrial fragmentation involved in apoptotic process (GO:0043653)	3.35885469
48	glutamate receptor signaling pathway (GO:0007215)	3.35502953
49	gamma-aminobutyric acid signaling pathway (GO:0007214)	3.30875963
50	skeletal muscle organ development (GO:0060538)	3.29801514
51	response to auditory stimulus (GO:0010996)	3.28671351
52	neurotransmitter transport (GO:0006836)	3.17447444
53	C4-dicarboxylate transport (GO:0015740)	3.16002607
54	positive regulation of excitatory postsynaptic membrane potential (GO:2000463)	3.15841083
55	negative regulation of telomere maintenance (GO:0032205)	3.12867280
56	regulation of synapse structural plasticity (GO:0051823)	3.10897136
57	protein-cofactor linkage (GO:0018065)	3.10480556
58	adhesion of symbiont to host (GO:0044406)	3.07420254
59	regulation of voltage-gated calcium channel activity (GO:1901385)	3.06105596
60	clathrin coat assembly (GO:0048268)	3.04164796
61	potassium ion homeostasis (GO:0055075)	3.03368767
62	regulation of neuronal synaptic plasticity (GO:0048168)	3.02337414
63	regulation of synapse maturation (GO:0090128)	2.99767895
64	postsynaptic membrane organization (GO:0001941)	2.99747080
65	positive regulation of dendritic spine development (GO:0060999)	2.98987472
66	vocalization behavior (GO:0071625)	2.98614025
67	membrane depolarization (GO:0051899)	2.98509068
68	locomotory exploration behavior (GO:0035641)	2.97938977
69	positive regulation of cGMP biosynthetic process (GO:0030828)	2.95521184
70	regulation of vesicle fusion (GO:0031338)	2.94785976
71	regulation of cAMP-mediated signaling (GO:0043949)	2.92211510
72	regulation of excitatory postsynaptic membrane potential (GO:0060079)	2.88693449
73	regulation of dendritic spine morphogenesis (GO:0061001)	2.87352998
74	proline transport (GO:0015824)	2.87167009
75	adult walking behavior (GO:0007628)	2.86158609
76	sleep (GO:0030431)	2.84998435
77	dendritic spine morphogenesis (GO:0060997)	2.84795156
78	dendritic spine organization (GO:0097061)	2.83604459
79	auditory receptor cell stereocilium organization (GO:0060088)	2.83023554
80	regulation of neurotransmitter levels (GO:0001505)	2.81890929
81	regulation of female gonad development (GO:2000194)	2.81833675
82	axon ensheathment in central nervous system (GO:0032291)	2.81628687
83	central nervous system myelination (GO:0022010)	2.81628687
84	potassium ion import (GO:0010107)	2.81616696
85	neuromuscular process controlling posture (GO:0050884)	2.80267467
86	establishment of vesicle localization (GO:0051650)	2.79444127
87	G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)	2.79098432
88	cellular sodium ion homeostasis (GO:0006883)	2.78683637
89	epithelial cell differentiation involved in kidney development (GO:0035850)	2.78312780
90	neuron-neuron synaptic transmission (GO:0007270)	2.78032769
91	detection of light stimulus involved in sensory perception (GO:0050962)	2.77136246
92	detection of light stimulus involved in visual perception (GO:0050908)	2.77136246
93	exploration behavior (GO:0035640)	2.75988721
94	positive regulation of dendritic spine morphogenesis (GO:0061003)	2.75860080
95	regulation of cGMP biosynthetic process (GO:0030826)	2.74845611
96	L-amino acid import (GO:0043092)	2.73729920
97	regulation of cardiac muscle cell contraction (GO:0086004)	2.73583689
98	long term synaptic depression (GO:0060292)	2.73068960
99	negative regulation of dendrite morphogenesis (GO:0050774)	2.72038982
100	phosphorelay signal transduction system (GO:0000160)	2.71836581

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	4.21300518
2	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	3.15939395
3	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	2.96363888
4	REST_21632747_ChIP-Seq_MESCs_Mouse	2.87644461
5	EZH2_22144423_ChIP-Seq_EOC_Human	2.81590046
6	IKZF1_21737484_ChIP-ChIP_HCT116_Human	2.66933297
7	JARID2_20064375_ChIP-Seq_MESCs_Mouse	2.66749249
8	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	2.55678135
9	MTF2_20144788_ChIP-Seq_MESCs_Mouse	2.53664759
10	EZH2_18974828_ChIP-Seq_MESCs_Mouse	2.50219997
11	RNF2_18974828_ChIP-Seq_MESCs_Mouse	2.50219997
12	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	2.46618982
13	JARID2_20075857_ChIP-Seq_MESCs_Mouse	2.38801689
14	GBX2_23144817_ChIP-Seq_PC3_Human	2.32793699
15	EGR1_19032775_ChIP-ChIP_M12_Human	2.29423407
16	REST_18959480_ChIP-ChIP_MESCs_Mouse	2.23230484
17	DROSHA_22980978_ChIP-Seq_HELA_Human	2.20740232
18	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	2.18982484
19	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.13859854
20	SRY_22984422_ChIP-ChIP_TESTIS_Rat	2.10814870
21	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	2.09909807
22	EED_16625203_ChIP-ChIP_MESCs_Mouse	2.08126746
23	RARB_27405468_Chip-Seq_BRAIN_Mouse	2.02106080
24	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.94575318
25	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.94294709
26	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.92666366
27	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.91562679
28	NR3C1_23031785_ChIP-Seq_PC12_Mouse	1.86343576
29	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.79744939
30	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.79318587
31	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	1.58883007
32	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.44546721
33	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.43070146
34	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.40888268
35	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.37637251
36	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.32382624
37	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.31232544
38	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.29520725
39	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.29514218
40	RNF2_27304074_Chip-Seq_NSC_Mouse	1.29026104
41	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.27577792
42	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.26188397
43	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.16578996
44	TET1_21490601_ChIP-Seq_MESCs_Mouse	1.16307163
45	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	1.14581909
46	WT1_25993318_ChIP-Seq_PODOCYTE_Human	1.13133752
47	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.11931329
48	OCT4_19829295_ChIP-Seq_ESCs_Human	1.11444954
49	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.09599747
50	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.09078993
51	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.06440711
52	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	1.06062720
53	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.05365602
54	SMC4_20622854_ChIP-Seq_HELA_Human	1.03126928
55	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.02502533
56	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.02261849
57	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.00695997
58	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.00559215
59	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.00189185
60	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.99723716
61	RAD21_21589869_ChIP-Seq_MESCs_Mouse	0.98283349
62	FLI1_27457419_Chip-Seq_LIVER_Mouse	0.97949460
63	AR_19668381_ChIP-Seq_PC3_Human	0.97390515
64	GATA1_26923725_Chip-Seq_HPCs_Mouse	0.95718655
65	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.95549471
66	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.92243739
67	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.91724290
68	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.91477207
69	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	0.91047140
70	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	0.90889773
71	HTT_18923047_ChIP-ChIP_STHdh_Human	0.90499776
72	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.90279458
73	EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	0.88965073
74	P68_20966046_ChIP-Seq_HELA_Human	0.87590903
75	* CTCF_27219007_Chip-Seq_Bcells_Human	0.87413643
76	JUN_21703547_ChIP-Seq_K562_Human	0.87194959
77	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.85927185
78	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	0.85274612
79	KDM2B_26808549_Chip-Seq_K562_Human	0.85034153
80	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.84187855
81	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.84017097
82	YAP1_20516196_ChIP-Seq_MESCs_Mouse	0.83968672
83	AR_25329375_ChIP-Seq_VCAP_Human	0.83416467
84	ZFP281_18757296_ChIP-ChIP_E14_Mouse	0.83267355
85	GATA3_21867929_ChIP-Seq_TH1_Mouse	0.82980938
86	PPARG_20176806_ChIP-Seq_3T3-L1_Mouse	0.82590043
87	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.81779549
88	TP53_20018659_ChIP-ChIP_R1E_Mouse	0.80768244
89	OLIG2_26023283_ChIP-Seq_AINV15_Mouse	0.80746338
90	SMAD4_21799915_ChIP-Seq_A2780_Human	0.80186538
91	SMAD4_21741376_ChIP-Seq_ESCs_Human	0.80026232
92	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.79707829
93	EP300_21415370_ChIP-Seq_HL-1_Mouse	0.79637903
94	GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.78803936
95	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.78533838
96	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.78273540
97	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.78202849
98	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	0.78089379
99	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.77493277
100	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.76598667

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004859_abnormal_synaptic_plasticity	4.53992958
2	MP0000751_myopathy	4.30115649
3	MP0004270_analgesia	4.03652078
4	MP0003880_abnormal_central_pattern	3.99568114
5	MP0001501_abnormal_sleep_pattern	3.52356849
6	MP0009046_muscle_twitch	3.49124266
7	MP0002064_seizures	3.36329218
8	MP0001486_abnormal_startle_reflex	3.35789565
9	MP0003635_abnormal_synaptic_transmissio	3.28155073
10	MP0002272_abnormal_nervous_system	3.16274961
11	MP0009745_abnormal_behavioral_response	3.08126866
12	MP0001188_hyperpigmentation	2.85470696
13	MP0002063_abnormal_learning/memory/cond	2.45370700
14	MP0001968_abnormal_touch/_nociception	2.30442094
15	MP0003329_amyloid_beta_deposits	2.27297850
16	MP0005551_abnormal_eye_electrophysiolog	2.24584404
17	MP0000920_abnormal_myelination	2.23937299
18	MP0002572_abnormal_emotion/affect_behav	2.23769004
19	MP0005423_abnormal_somatic_nervous	2.15191892
20	MP0001485_abnormal_pinna_reflex	2.12583593
21	MP0002734_abnormal_mechanical_nocicepti	1.93427488
22	MP0001440_abnormal_grooming_behavior	1.85956080
23	MP0005167_abnormal_blood-brain_barrier	1.83498026
24	MP0002733_abnormal_thermal_nociception	1.81596555
25	MP0002736_abnormal_nociception_after	1.75416528
26	MP0000604_amyloidosis	1.73728099
27	MP0002735_abnormal_chemical_nociception	1.71354650
28	MP0001970_abnormal_pain_threshold	1.67851259
29	MP0004742_abnormal_vestibular_system	1.66261847
30	MP0004885_abnormal_endolymph	1.61181134
31	MP0008877_abnormal_DNA_methylation	1.61177930
32	MP0008569_lethality_at_weaning	1.58140858
33	MP0008995_early_reproductive_senescence	1.52089355
34	MP0003690_abnormal_glial_cell	1.45550599
35	MP0004924_abnormal_behavior	1.45327741
36	MP0005386_behavior/neurological_phenoty	1.45327741
37	MP0003633_abnormal_nervous_system	1.44566266
38	MP0003879_abnormal_hair_cell	1.44402283
39	MP0002067_abnormal_sensory_capabilities	1.41446882
40	MP0003878_abnormal_ear_physiology	1.41198058
41	MP0005377_hearing/vestibular/ear_phenot	1.41198058
42	MP0003631_nervous_system_phenotype	1.39372471
43	MP0000747_muscle_weakness	1.39346727
44	MP0002653_abnormal_ependyma_morphology	1.33398154
45	MP0004233_abnormal_muscle_weight	1.31291197
46	MP0000749_muscle_degeneration	1.27775610
47	MP0006276_abnormal_autonomic_nervous	1.27515972
48	MP0002822_catalepsy	1.26803174
49	MP0003183_abnormal_peptide_metabolism	1.26451196
50	MP0002229_neurodegeneration	1.25159823
51	MP0004811_abnormal_neuron_physiology	1.23471440
52	MP0003632_abnormal_nervous_system	1.23441806
53	MP0002066_abnormal_motor_capabilities/c	1.21124236
54	MP0002557_abnormal_social/conspecific_i	1.21091324
55	MP0003123_paternal_imprinting	1.20117174
56	MP0003787_abnormal_imprinting	1.20043391
57	MP0003122_maternal_imprinting	1.18525336
58	MP0001502_abnormal_circadian_rhythm	1.12738308
59	MP0004215_abnormal_myocardial_fiber	1.11571539
60	MP0003191_abnormal_cellular_cholesterol	1.07880868
61	MP0003315_abnormal_perineum_morphology	1.03957024
62	MP0002882_abnormal_neuron_morphology	1.03810803
63	MP0005535_abnormal_body_temperature	1.03473680
64	MP0006138_congestive_heart_failure	0.99292060
65	MP0008260_abnormal_autophagy	0.97076436
66	MP0000639_abnormal_adrenal_gland	0.92290375
67	MP0009384_cardiac_valve_regurgitation	0.88860030
68	MP0000537_abnormal_urethra_morphology	0.88197965
69	MP0001963_abnormal_hearing_physiology	0.86889733
70	MP0008874_decreased_physiological_sensi	0.86484174
71	MP0010386_abnormal_urinary_bladder	0.85609339
72	MP0003075_altered_response_to	0.85082249
73	MP0009840_abnormal_foam_cell	0.84584189
74	MP0002090_abnormal_vision	0.84079403
75	MP0000955_abnormal_spinal_cord	0.79750206
76	MP0005595_abnormal_vascular_smooth	0.79690906
77	MP0003172_abnormal_lysosome_physiology	0.79393478
78	MP0004142_abnormal_muscle_tone	0.78874998
79	MP0005646_abnormal_pituitary_gland	0.76738746
80	MP0000566_synostosis	0.76365749
81	MP0002184_abnormal_innervation	0.76292135
82	MP0000343_altered_response_to	0.75313649
83	MP0009780_abnormal_chondrocyte_physiolo	0.73721322
84	MP0001919_abnormal_reproductive_system	0.71760288
85	MP0001177_atelectasis	0.71111796
86	MP0002295_abnormal_pulmonary_circulatio	0.66838440
87	MP0003828_pulmonary_edema	0.65949494
88	MP0000778_abnormal_nervous_system	0.65106493
89	MP0005310_abnormal_salivary_gland	0.61799353
90	MP0000750_abnormal_muscle_regeneration	0.60919250
91	MP0001324_abnormal_eye_pigmentation	0.60455550
92	MP0002277_abnormal_respiratory_mucosa	0.60319813
93	MP0004484_altered_response_of	0.56919977
94	MP0003121_genomic_imprinting	0.56481536
95	MP0005448_abnormal_energy_balance	0.55960676
96	MP0003638_abnormal_response/metabolism_	0.55127744
97	MP0009785_altered_susceptibility_to	0.54688753
98	MP0002148_abnormal_hypersensitivity_rea	0.54227410
99	MP0005410_abnormal_fertilization	0.53703938
100	MP0004019_abnormal_vitamin_homeostasis	0.53666444

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Focal motor seizures (HP:0011153)	5.66992801
2	Myokymia (HP:0002411)	5.26784017
3	Epileptic encephalopathy (HP:0200134)	5.21428682
4	Amblyopia (HP:0000646)	4.33368798
5	Gaze-evoked nystagmus (HP:0000640)	4.14245950
6	Ulnar claw (HP:0001178)	4.07850302
7	Focal seizures (HP:0007359)	4.00754198
8	Systemic lupus erythematosus (HP:0002725)	4.00690863
9	Mesangial abnormality (HP:0001966)	3.90184585
10	Abnormality of the vocal cords (HP:0008777)	3.78919890
11	Shoulder girdle muscle weakness (HP:0003547)	3.71044399
12	Supranuclear gaze palsy (HP:0000605)	3.67457252
13	Peripheral hypomyelination (HP:0007182)	3.67236869
14	Atonic seizures (HP:0010819)	3.52835399
15	Gonadal dysgenesis (HP:0000133)	3.50327981
16	Anomalous pulmonary venous return (HP:0010772)	3.45037502
17	Transposition of the great arteries (HP:0001669)	3.26655974
18	Abnormal connection of the cardiac segments (HP:0011545)	3.26655974
19	Abnormal ventriculo-arterial connection (HP:0011563)	3.26655974
20	Febrile seizures (HP:0002373)	3.24259087
21	Decreased number of large peripheral myelinated nerve fibers (HP:0003387)	3.23523268
22	Hypoplastic left heart (HP:0004383)	3.20366932
23	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	3.15293210
24	Degeneration of the lateral corticospinal tracts (HP:0002314)	3.15293210
25	Mutism (HP:0002300)	3.14116724
26	Glomerulonephritis (HP:0000099)	3.14032628
27	Action tremor (HP:0002345)	3.12214559
28	Testicular neoplasm (HP:0010788)	3.10707999
29	Abnormal eating behavior (HP:0100738)	3.09180341
30	Hydroureter (HP:0000072)	3.05421922
31	Sleep apnea (HP:0010535)	2.96109366
32	Abnormality of the pulmonary veins (HP:0011718)	2.93500431
33	Spastic gait (HP:0002064)	2.91561959
34	Abnormality of binocular vision (HP:0011514)	2.88982649
35	Diplopia (HP:0000651)	2.88982649
36	Neurofibrillary tangles (HP:0002185)	2.88237688
37	Ankle clonus (HP:0011448)	2.87229009
38	Generalized tonic-clonic seizures (HP:0002069)	2.83569270
39	Cerebral hypomyelination (HP:0006808)	2.81498780
40	Abnormality of the lower motor neuron (HP:0002366)	2.79813762
41	Complement deficiency (HP:0004431)	2.69165616
42	Dysmetria (HP:0001310)	2.68945067
43	Abnormality of the corticospinal tract (HP:0002492)	2.68049355
44	Postural instability (HP:0002172)	2.66555965
45	Hyperventilation (HP:0002883)	2.63981193
46	Progressive inability to walk (HP:0002505)	2.56220719
47	Coronal craniosynostosis (HP:0004440)	2.55700125
48	Hemiplegia (HP:0002301)	2.55254736
49	Hypoplastic heart (HP:0001961)	2.49366484
50	Urinary bladder sphincter dysfunction (HP:0002839)	2.44342008
51	Papilledema (HP:0001085)	2.42208994
52	Optic nerve hypoplasia (HP:0000609)	2.41459871
53	Hypokalemic alkalosis (HP:0001949)	2.40623612
54	Amyotrophic lateral sclerosis (HP:0007354)	2.38251172
55	Abnormality of the labia minora (HP:0012880)	2.37668895
56	Type II lissencephaly (HP:0007260)	2.34281288
57	Absence seizures (HP:0002121)	2.32017064
58	Exercise-induced myalgia (HP:0003738)	2.31141456
59	Limb dystonia (HP:0002451)	2.29555205
60	Neuronal loss in central nervous system (HP:0002529)	2.26687094
61	Dialeptic seizures (HP:0011146)	2.26228674
62	Abnormality of the middle phalanges of the toes (HP:0010183)	2.25665978
63	Emotional lability (HP:0000712)	2.24275667
64	Pelvic girdle muscle weakness (HP:0003749)	2.19181155
65	Rapidly progressive (HP:0003678)	2.11237347
66	Neoplasm of head and neck (HP:0012288)	2.06482237
67	Esophageal neoplasm (HP:0100751)	2.06482237
68	Flared iliac wings (HP:0002869)	2.06190851
69	Germ cell neoplasia (HP:0100728)	2.04583484
70	Lower limb muscle weakness (HP:0007340)	2.04260266
71	Retinal dysplasia (HP:0007973)	1.99402807
72	Tetraplegia (HP:0002445)	1.98415935
73	Polyphagia (HP:0002591)	1.96845944
74	Memory impairment (HP:0002354)	1.96817960
75	CNS hypomyelination (HP:0003429)	1.96486873
76	Progressive cerebellar ataxia (HP:0002073)	1.96445568
77	Status epilepticus (HP:0002133)	1.95128549
78	Centrally nucleated skeletal muscle fibers (HP:0003687)	1.93850783
79	Cerebral inclusion bodies (HP:0100314)	1.92994431
80	True hermaphroditism (HP:0010459)	1.91434272
81	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.91035341
82	Sensory axonal neuropathy (HP:0003390)	1.91029266
83	Choreoathetosis (HP:0001266)	1.89602642
84	Preauricular pit (HP:0004467)	1.89581582
85	Periauricular skin pits (HP:0100277)	1.89581582
86	Urinary urgency (HP:0000012)	1.88897212
87	Increased serum pyruvate (HP:0003542)	1.88808906
88	Xerostomia (HP:0000217)	1.86816962
89	Abnormality of the hip-girdle musculature (HP:0001445)	1.85104854
90	Abnormality of the musculature of the pelvis (HP:0001469)	1.85104854
91	Iris hypopigmentation (HP:0007730)	1.85069645
92	Torticollis (HP:0000473)	1.84215360
93	Hyperaldosteronism (HP:0000859)	1.83868568
94	Glomerulosclerosis (HP:0000096)	1.83826829
95	Truncal ataxia (HP:0002078)	1.83691581
96	Annular pancreas (HP:0001734)	1.83615458
97	Depression (HP:0000716)	1.82032014
98	Rimmed vacuoles (HP:0003805)	1.81876851
99	Abnormality of glycolipid metabolism (HP:0010969)	1.79622866
100	Abnormality of glycosphingolipid metabolism (HP:0004343)	1.79622866

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BLK	4.45958828
2	CDK19	3.70835516
3	MAP3K12	3.38994701
4	DAPK2	3.32229057
5	OXSR1	3.21931079
6	CAMKK2	2.83053057
7	EPHA4	2.70722277
8	NTRK3	2.61835271
9	SIK2	2.35597406
10	MAP3K4	2.25309239
11	STK38	2.25244676
12	DYRK1A	2.17020533
13	MAP3K11	2.11873840
14	MARK1	2.11274204
15	PNCK	2.10186525
16	CAMKK1	2.03475867
17	MINK1	2.02174043
18	PAK6	2.00338904
19	LATS2	1.91987188
20	NTRK2	1.89594219
21	CAMK1	1.61120622
22	CDK18	1.46746074
23	CDK15	1.42155371
24	CDK5	1.38406601
25	UHMK1	1.38109612
26	RIPK1	1.36307865
27	MAP2K4	1.34190269
28	CDK11A	1.25520374
29	TRIM28	1.21587806
30	ERN1	1.20427250
31	GRK5	1.16412993
32	JAK1	1.15839901
33	BMPR2	1.13149165
34	PRKCG	1.12704466
35	KSR1	1.11635198
36	CDK14	1.11578392
37	FES	1.10867352
38	CAMK1G	1.10515058
39	RIPK4	1.08185570
40	CAMK2B	1.02989646
41	PRKCH	1.02571283
42	SGK223	1.02545318
43	SGK494	1.02545318
44	PRKD3	0.96468931
45	SGK2	0.95738870
46	PRKCZ	0.93081464
47	MAPK13	0.91711980
48	CAMK2A	0.90659180
49	EPHB2	0.90346553
50	ALK	0.90157783
51	PHKG2	0.89759775
52	PHKG1	0.89759775
53	TIE1	0.88451057
54	BRSK1	0.88440791
55	MAP3K1	0.83274792
56	SIK3	0.83134574
57	CAMK4	0.83133712
58	ABL2	0.82132168
59	FER	0.81044969
60	CAMK2G	0.80438550
61	FGFR2	0.77402584
62	MAPKAPK5	0.75723000
63	NTRK1	0.71811430
64	DAPK1	0.69258343
65	MAP2K6	0.67841575
66	SGK1	0.67408655
67	PINK1	0.66269131
68	STK39	0.64943944
69	WNK1	0.63538950
70	SGK3	0.62642828
71	PDK2	0.62005212
72	NEK6	0.60532659
73	STK11	0.59986692
74	CASK	0.58471291
75	PDPK1	0.57810441
76	DAPK3	0.56451102
77	MAPK12	0.56078102
78	PRKG2	0.53950994
79	MAPK10	0.52145064
80	MAP3K7	0.49580815
81	PKN1	0.48279530
82	TYK2	0.47258319
83	PLK2	0.43728602
84	PDK1	0.43373536
85	PRKCE	0.42427738
86	CAMK2D	0.42072694
87	RPS6KA3	0.41174443
88	EPHA3	0.39406628
89	INSRR	0.38886783
90	SYK	0.38705264
91	MAP3K5	0.38032558
92	PRKACA	0.37228462
93	RPS6KB1	0.37118597
94	WNK4	0.35730814
95	PRKCA	0.35623311
96	TLK1	0.35447903
97	MAP3K9	0.34755032
98	PAK3	0.32769083
99	FYN	0.30520766
100	JAK2	0.30114898

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	4.26758069
2	Nicotine addiction_Homo sapiens_hsa05033	3.79956479
3	Synaptic vesicle cycle_Homo sapiens_hsa04721	3.69564404
4	Staphylococcus aureus infection_Homo sapiens_hsa05150	2.89830997
5	GABAergic synapse_Homo sapiens_hsa04727	2.45103829
6	Morphine addiction_Homo sapiens_hsa05032	2.35615631
7	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	2.34320424
8	Circadian entrainment_Homo sapiens_hsa04713	2.23720834
9	Glutamatergic synapse_Homo sapiens_hsa04724	2.23694957
10	Asthma_Homo sapiens_hsa05310	2.12594643
11	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.90326306
12	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.84047627
13	Cardiac muscle contraction_Homo sapiens_hsa04260	1.79430383
14	Amphetamine addiction_Homo sapiens_hsa05031	1.70631285
15	Long-term potentiation_Homo sapiens_hsa04720	1.66823264
16	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.65097442
17	Insulin secretion_Homo sapiens_hsa04911	1.64865143
18	Allograft rejection_Homo sapiens_hsa05330	1.63771818
19	Oxidative phosphorylation_Homo sapiens_hsa00190	1.61218015
20	Collecting duct acid secretion_Homo sapiens_hsa04966	1.59476072
21	Gastric acid secretion_Homo sapiens_hsa04971	1.55766564
22	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.53410403
23	Rheumatoid arthritis_Homo sapiens_hsa05323	1.46009433
24	Phagosome_Homo sapiens_hsa04145	1.45825756
25	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	1.45465949
26	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.43893151
27	Salivary secretion_Homo sapiens_hsa04970	1.37440291
28	Type I diabetes mellitus_Homo sapiens_hsa04940	1.36421460
29	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.34742950
30	Dopaminergic synapse_Homo sapiens_hsa04728	1.34004259
31	Cocaine addiction_Homo sapiens_hsa05030	1.31861536
32	Alzheimers disease_Homo sapiens_hsa05010	1.31076208
33	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	1.29793287
34	Arginine and proline metabolism_Homo sapiens_hsa00330	1.28575022
35	Graft-versus-host disease_Homo sapiens_hsa05332	1.28291275
36	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	1.22614354
37	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.15283505
38	Calcium signaling pathway_Homo sapiens_hsa04020	1.15024350
39	Prion diseases_Homo sapiens_hsa05020	1.11283287
40	Chemokine signaling pathway_Homo sapiens_hsa04062	1.09279779
41	Circadian rhythm_Homo sapiens_hsa04710	1.08394480
42	Taste transduction_Homo sapiens_hsa04742	1.04178308
43	Parkinsons disease_Homo sapiens_hsa05012	1.03333513
44	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.01882473
45	Renin secretion_Homo sapiens_hsa04924	1.00820639
46	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.99897072
47	Cholinergic synapse_Homo sapiens_hsa04725	0.99750055
48	Tuberculosis_Homo sapiens_hsa05152	0.97611791
49	Histidine metabolism_Homo sapiens_hsa00340	0.95690527
50	Leishmaniasis_Homo sapiens_hsa05140	0.92752302
51	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.91351794
52	Olfactory transduction_Homo sapiens_hsa04740	0.91121636
53	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.90862938
54	cAMP signaling pathway_Homo sapiens_hsa04024	0.90193626
55	Serotonergic synapse_Homo sapiens_hsa04726	0.87852900
56	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.86301947
57	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.85646015
58	GnRH signaling pathway_Homo sapiens_hsa04912	0.85635370
59	Long-term depression_Homo sapiens_hsa04730	0.81926116
60	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.79227536
61	Viral myocarditis_Homo sapiens_hsa05416	0.75947660
62	Complement and coagulation cascades_Homo sapiens_hsa04610	0.75377044
63	Mineral absorption_Homo sapiens_hsa04978	0.70698042
64	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.67074008
65	Vibrio cholerae infection_Homo sapiens_hsa05110	0.66243373
66	Bile secretion_Homo sapiens_hsa04976	0.65735217
67	Pancreatic secretion_Homo sapiens_hsa04972	0.65664391
68	Fatty acid elongation_Homo sapiens_hsa00062	0.55397556
69	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.54933002
70	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.52887109
71	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.52388215
72	Huntingtons disease_Homo sapiens_hsa05016	0.51934254
73	Endocytosis_Homo sapiens_hsa04144	0.48902678
74	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.47555530
75	Ras signaling pathway_Homo sapiens_hsa04014	0.46808392
76	Lysosome_Homo sapiens_hsa04142	0.46642045
77	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.46155185
78	Nitrogen metabolism_Homo sapiens_hsa00910	0.45679174
79	Melanogenesis_Homo sapiens_hsa04916	0.44462541
80	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.43922307
81	Phenylalanine metabolism_Homo sapiens_hsa00360	0.43739837
82	Folate biosynthesis_Homo sapiens_hsa00790	0.41676249
83	beta-Alanine metabolism_Homo sapiens_hsa00410	0.40779571
84	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.40587211
85	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.40475303
86	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.40375479
87	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.39877794
88	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.36563009
89	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.32066093
90	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.31795292
91	Arginine biosynthesis_Homo sapiens_hsa00220	0.30872901
92	Gap junction_Homo sapiens_hsa04540	0.30003602
93	MAPK signaling pathway_Homo sapiens_hsa04010	0.28844146
94	Pyruvate metabolism_Homo sapiens_hsa00620	0.27614050
95	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.25395687
96	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.24898131
97	Estrogen signaling pathway_Homo sapiens_hsa04915	0.24874483
98	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.24753170
99	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.23020784
100	Antigen processing and presentation_Homo sapiens_hsa04612	0.22732381

CLEC4GP1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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