CLEC4M

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a transmembrane receptor and is often referred to as L-SIGN because of its expression in the endothelial cells of the lymph nodes and liver. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses, with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are common and have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 30835; often referred to as DC-SIGN or CD209). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1exogenous drug catabolic process (GO:0042738)7.49216046
2drug catabolic process (GO:0042737)6.92225780
3omega-hydroxylase P450 pathway (GO:0097267)6.58247864
4epoxygenase P450 pathway (GO:0019373)6.39704102
5glyoxylate metabolic process (GO:0046487)5.69768882
6oxidative demethylation (GO:0070989)5.23890657
7L-phenylalanine catabolic process (GO:0006559)4.89949003
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.89949003
9aromatic amino acid family catabolic process (GO:0009074)4.89350221
10indole-containing compound catabolic process (GO:0042436)4.88817970
11indolalkylamine catabolic process (GO:0046218)4.88817970
12tryptophan catabolic process (GO:0006569)4.88817970
13ethanol oxidation (GO:0006069)4.84424642
14S-adenosylmethionine metabolic process (GO:0046500)4.77643319
15drug metabolic process (GO:0017144)4.74725839
16behavioral response to nicotine (GO:0035095)4.68743404
17complement activation, alternative pathway (GO:0006957)4.65528891
18regulation of protein activation cascade (GO:2000257)4.41472000
19serine family amino acid catabolic process (GO:0009071)4.41064177
20imidazole-containing compound metabolic process (GO:0052803)4.31458452
21indolalkylamine metabolic process (GO:0006586)4.26116267
22cellular ketone body metabolic process (GO:0046950)4.24009217
23regulation of complement activation (GO:0030449)4.21857295
24tryptophan metabolic process (GO:0006568)4.21583011
25bile acid biosynthetic process (GO:0006699)4.17718393
26phenylpropanoid metabolic process (GO:0009698)4.14054442
27erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.03208646
28L-phenylalanine metabolic process (GO:0006558)4.03208646
29water-soluble vitamin biosynthetic process (GO:0042364)3.86880675
30ethanol metabolic process (GO:0006067)3.86239901
31ketone body metabolic process (GO:1902224)3.78585638
32regulation of fibrinolysis (GO:0051917)3.78489816
33amine catabolic process (GO:0009310)3.70289420
34cellular biogenic amine catabolic process (GO:0042402)3.70289420
35benzene-containing compound metabolic process (GO:0042537)3.66724282
36bile acid metabolic process (GO:0008206)3.66667610
37uronic acid metabolic process (GO:0006063)3.53043857
38glucuronate metabolic process (GO:0019585)3.53043857
39pyrimidine nucleobase catabolic process (GO:0006208)3.52457834
40cellular glucuronidation (GO:0052695)3.52400172
41kynurenine metabolic process (GO:0070189)3.49377152
42aromatic amino acid family metabolic process (GO:0009072)3.49293296
43regulation of triglyceride catabolic process (GO:0010896)3.47951682
44alpha-amino acid catabolic process (GO:1901606)3.47820013
45opsonization (GO:0008228)3.40630153
46heme transport (GO:0015886)3.34945845
47amino-acid betaine metabolic process (GO:0006577)3.32023740
48arginine metabolic process (GO:0006525)3.31166146
49aldehyde catabolic process (GO:0046185)3.29439662
50fucose catabolic process (GO:0019317)3.28157683
51L-fucose metabolic process (GO:0042354)3.28157683
52L-fucose catabolic process (GO:0042355)3.28157683
53cytolysis (GO:0019835)3.27435973
54cysteine metabolic process (GO:0006534)3.25704505
55protein carboxylation (GO:0018214)3.22437348
56peptidyl-glutamic acid carboxylation (GO:0017187)3.22437348
57negative regulation of protein activation cascade (GO:2000258)3.21952331
58triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.21900714
59triglyceride homeostasis (GO:0070328)3.20400061
60acylglycerol homeostasis (GO:0055090)3.20400061
61glycine metabolic process (GO:0006544)3.19722914
62vitamin biosynthetic process (GO:0009110)3.19698717
63coenzyme catabolic process (GO:0009109)3.14945448
64alkaloid metabolic process (GO:0009820)3.13040488
65blood coagulation, intrinsic pathway (GO:0007597)3.09875896
66nucleobase catabolic process (GO:0046113)3.09209864
67response to pheromone (GO:0019236)3.08681184
68cellular amino acid catabolic process (GO:0009063)3.05744584
69quinone biosynthetic process (GO:1901663)3.04314899
70L-methionine salvage (GO:0071267)3.03709842
71L-methionine biosynthetic process (GO:0071265)3.03709842
72amino acid salvage (GO:0043102)3.03709842
73indole-containing compound metabolic process (GO:0042430)3.02923088
74serine family amino acid metabolic process (GO:0009069)3.02246048
75arginine catabolic process (GO:0006527)3.00034847
76positive regulation of fatty acid transport (GO:2000193)2.99109699
77C4-dicarboxylate transport (GO:0015740)2.98957435
78protein activation cascade (GO:0072376)2.98627570
79flavonoid metabolic process (GO:0009812)2.94767254
80tyrosine metabolic process (GO:0006570)2.92705281
81bile acid and bile salt transport (GO:0015721)2.92606950
82xenobiotic metabolic process (GO:0006805)2.92041392
83piRNA metabolic process (GO:0034587)2.89529679
84complement activation (GO:0006956)2.88591606
85negative regulation of fibrinolysis (GO:0051918)2.87666294
86regulation of male gonad development (GO:2000018)2.86408485
87regulation of hexokinase activity (GO:1903299)2.85888566
88regulation of glucokinase activity (GO:0033131)2.85888566
89xenobiotic catabolic process (GO:0042178)2.85529704
90positive regulation of icosanoid secretion (GO:0032305)2.83648953
91high-density lipoprotein particle remodeling (GO:0034375)2.78049691
92ubiquinone biosynthetic process (GO:0006744)2.77949508
93complement activation, classical pathway (GO:0006958)2.77192596
94negative regulation of complement activation (GO:0045916)2.77029882
95platelet dense granule organization (GO:0060155)2.75749463
96peptidyl-glutamic acid modification (GO:0018200)2.73603597
97quinone metabolic process (GO:1901661)2.72734653
98regulation of humoral immune response (GO:0002920)2.71308502
99organic acid catabolic process (GO:0016054)2.69671754
100carboxylic acid catabolic process (GO:0046395)2.69671754

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.47086990
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.25779474
3VDR_22108803_ChIP-Seq_LS180_Human3.20539816
4EGR1_23403033_ChIP-Seq_LIVER_Mouse2.89246817
5IGF1R_20145208_ChIP-Seq_DFB_Human2.74981847
6GBX2_23144817_ChIP-Seq_PC3_Human2.74212607
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.42111604
8EZH2_22144423_ChIP-Seq_EOC_Human2.23593100
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.19741223
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.16915598
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.15673552
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.13463536
13ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.97742046
14CTBP1_25329375_ChIP-Seq_LNCAP_Human1.95747875
15CTBP2_25329375_ChIP-Seq_LNCAP_Human1.92665471
16PCGF2_27294783_Chip-Seq_ESCs_Mouse1.79734850
17TAF15_26573619_Chip-Seq_HEK293_Human1.78812443
18BCAT_22108803_ChIP-Seq_LS180_Human1.73233728
19ER_23166858_ChIP-Seq_MCF-7_Human1.72714175
20P300_19829295_ChIP-Seq_ESCs_Human1.72553921
21CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.69747151
22HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.69355987
23PCGF2_27294783_Chip-Seq_NPCs_Mouse1.63829420
24IRF1_19129219_ChIP-ChIP_H3396_Human1.62434233
25NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.61482314
26UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.58703563
27FUS_26573619_Chip-Seq_HEK293_Human1.57100099
28EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.53903090
29GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.51171212
30NFE2_27457419_Chip-Seq_LIVER_Mouse1.50954622
31EZH2_27294783_Chip-Seq_NPCs_Mouse1.50816840
32IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.50759211
33CBP_20019798_ChIP-Seq_JUKART_Human1.50759211
34CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.47802474
35SUZ12_27294783_Chip-Seq_NPCs_Mouse1.47735359
36AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.46692841
37EWS_26573619_Chip-Seq_HEK293_Human1.44977993
38TP53_22573176_ChIP-Seq_HFKS_Human1.44325140
39RXR_22158963_ChIP-Seq_LIVER_Mouse1.40412340
40NANOG_19829295_ChIP-Seq_ESCs_Human1.40336934
41SOX2_19829295_ChIP-Seq_ESCs_Human1.40336934
42MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.39387276
43AR_25329375_ChIP-Seq_VCAP_Human1.36700431
44TCF4_22108803_ChIP-Seq_LS180_Human1.36281936
45HTT_18923047_ChIP-ChIP_STHdh_Human1.35656404
46STAT3_23295773_ChIP-Seq_U87_Human1.35328546
47NCOR_22424771_ChIP-Seq_293T_Human1.34905501
48KLF5_20875108_ChIP-Seq_MESCs_Mouse1.33360455
49LXR_22158963_ChIP-Seq_LIVER_Mouse1.31029298
50NR3C1_21868756_ChIP-Seq_MCF10A_Human1.30172243
51PIAS1_25552417_ChIP-Seq_VCAP_Human1.29536612
52TCF4_23295773_ChIP-Seq_U87_Human1.28833129
53GABP_17652178_ChIP-ChIP_JURKAT_Human1.27085067
54CRX_20693478_ChIP-Seq_RETINA_Mouse1.25920966
55SMAD4_21799915_ChIP-Seq_A2780_Human1.25634102
56ETV2_25802403_ChIP-Seq_MESCs_Mouse1.25455648
57AR_20517297_ChIP-Seq_VCAP_Human1.24877519
58CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.23569499
59RUNX2_22187159_ChIP-Seq_PCA_Human1.21899894
60EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.21869118
61* PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.21238495
62NOTCH1_21737748_ChIP-Seq_TLL_Human1.21209707
63FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.19399618
64PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.18518146
65FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.17793808
66SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17014861
67CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.16032364
68FOXA1_27270436_Chip-Seq_PROSTATE_Human1.15942999
69FOXA1_25329375_ChIP-Seq_VCAP_Human1.15942999
70MYC_18940864_ChIP-ChIP_HL60_Human1.15874968
71SMAD4_21741376_ChIP-Seq_EPCs_Human1.15437186
72AUTS2_25519132_ChIP-Seq_293T-REX_Human1.15374419
73POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.15076868
74TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15076868
75MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.13549257
76GATA3_21878914_ChIP-Seq_MCF-7_Human1.13312260
77CDX2_22108803_ChIP-Seq_LS180_Human1.12680641
78REST_21632747_ChIP-Seq_MESCs_Mouse1.11556656
79HOXB7_26014856_ChIP-Seq_BT474_Human1.10836410
80KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.10106633
81SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10002024
82FOXA1_21572438_ChIP-Seq_LNCaP_Human1.08764220
83EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.08355884
84SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.08212100
85FOXH1_21741376_ChIP-Seq_EPCs_Human1.07354713
86MYC_19829295_ChIP-Seq_ESCs_Human1.07190974
87RNF2_27304074_Chip-Seq_NSC_Mouse1.05966712
88BMI1_23680149_ChIP-Seq_NPCS_Mouse1.05908710
89SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.05430972
90MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.05377230
91IRF8_22096565_ChIP-ChIP_GC-B_Human1.05239496
92PPARA_22158963_ChIP-Seq_LIVER_Mouse1.04937085
93CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.04709364
94OCT4_21477851_ChIP-Seq_ESCs_Mouse1.04473053
95TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03946283
96NANOG_18555785_Chip-Seq_ESCs_Mouse1.03318530
97SMAD3_21741376_ChIP-Seq_EPCs_Human1.03310395
98TOP2B_26459242_ChIP-Seq_MCF-7_Human1.02614657
99STAT3_18555785_Chip-Seq_ESCs_Mouse1.01930629
100P53_22387025_ChIP-Seq_ESCs_Mouse1.01152602

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003195_calcinosis4.93317040
2MP0008875_abnormal_xenobiotic_pharmacok4.66129034
3MP0002139_abnormal_hepatobiliary_system4.37895003
4MP0005085_abnormal_gallbladder_physiolo3.66881639
5MP0005360_urolithiasis3.62339935
6MP0005365_abnormal_bile_salt3.17516075
7MP0002138_abnormal_hepatobiliary_system3.04801652
8MP0006292_abnormal_olfactory_placode2.92540294
9MP0003252_abnormal_bile_duct2.52032063
10MP0008877_abnormal_DNA_methylation2.34292281
11MP0005551_abnormal_eye_electrophysiolog2.05017165
12MP0008995_early_reproductive_senescence2.03661224
13MP0003011_delayed_dark_adaptation1.99984642
14MP0002876_abnormal_thyroid_physiology1.96185036
15MP0005332_abnormal_amino_acid1.95348793
16MP0010329_abnormal_lipoprotein_level1.91728495
17MP0002102_abnormal_ear_morphology1.88066360
18MP0008872_abnormal_physiological_respon1.87462453
19MP0003787_abnormal_imprinting1.85467348
20MP0001764_abnormal_homeostasis1.63252328
21MP0001501_abnormal_sleep_pattern1.62884497
22MP0005646_abnormal_pituitary_gland1.62291509
23MP0006276_abnormal_autonomic_nervous1.52356935
24MP0001968_abnormal_touch/_nociception1.48324274
25MP0006072_abnormal_retinal_apoptosis1.47668798
26MP0002837_dystrophic_cardiac_calcinosis1.47081291
27MP0002234_abnormal_pharynx_morphology1.46932996
28MP0001984_abnormal_olfaction1.44830719
29MP0002736_abnormal_nociception_after1.40634464
30MP0000639_abnormal_adrenal_gland1.40441745
31MP0003122_maternal_imprinting1.36538250
32MP0005253_abnormal_eye_physiology1.35383610
33MP0001661_extended_life_span1.31241425
34MP0002638_abnormal_pupillary_reflex1.28115507
35MP0009745_abnormal_behavioral_response1.22916416
36MP0005389_reproductive_system_phenotype1.22464961
37MP0003121_genomic_imprinting1.22338013
38MP0005670_abnormal_white_adipose1.22097723
39MP0002909_abnormal_adrenal_gland1.20913788
40MP0005075_abnormal_melanosome_morpholog1.19753990
41MP0004019_abnormal_vitamin_homeostasis1.19087570
42MP0009764_decreased_sensitivity_to1.18038748
43MP0002272_abnormal_nervous_system1.15874193
44MP0000372_irregular_coat_pigmentation1.15740136
45MP0001986_abnormal_taste_sensitivity1.14431805
46MP0000631_abnormal_neuroendocrine_gland1.14323125
47MP0004885_abnormal_endolymph1.13601234
48MP0002160_abnormal_reproductive_system1.12823031
49MP0002653_abnormal_ependyma_morphology1.11352869
50MP0004142_abnormal_muscle_tone1.08313172
51MP0001486_abnormal_startle_reflex1.08158890
52MP0001666_abnormal_nutrient_absorption1.07773130
53MP0001529_abnormal_vocalization1.07214132
54MP0004147_increased_porphyrin_level1.05933116
55MP0002938_white_spotting1.03535396
56MP0002254_reproductive_system_inflammat1.03444144
57MP0005410_abnormal_fertilization1.02722181
58MP0001919_abnormal_reproductive_system1.02159724
59MP0004133_heterotaxia1.02084724
60MP0009046_muscle_twitch1.01116157
61MP0002118_abnormal_lipid_homeostasis0.96295255
62MP0001485_abnormal_pinna_reflex0.94842019
63MP0010386_abnormal_urinary_bladder0.94135269
64MP0008789_abnormal_olfactory_epithelium0.88438341
65MP0003880_abnormal_central_pattern0.88083907
66MP0005408_hypopigmentation0.87004925
67MP0005645_abnormal_hypothalamus_physiol0.85089256
68MP0005367_renal/urinary_system_phenotyp0.84676998
69MP0000516_abnormal_urinary_system0.84676998
70MP0005535_abnormal_body_temperature0.84657265
71MP0003806_abnormal_nucleotide_metabolis0.84395685
72MP0005636_abnormal_mineral_homeostasis0.84354605
73MP0009697_abnormal_copulation0.82514093
74MP0005195_abnormal_posterior_eye0.81971590
75MP0002557_abnormal_social/conspecific_i0.81733145
76MP0004924_abnormal_behavior0.80917368
77MP0005386_behavior/neurological_phenoty0.80917368
78MP0000569_abnormal_digit_pigmentation0.80348369
79MP0005084_abnormal_gallbladder_morpholo0.78113541
80MP0002572_abnormal_emotion/affect_behav0.75893287
81MP0003878_abnormal_ear_physiology0.75477997
82MP0005377_hearing/vestibular/ear_phenot0.75477997
83MP0003186_abnormal_redox_activity0.75159089
84MP0004043_abnormal_pH_regulation0.74620853
85MP0010368_abnormal_lymphatic_system0.74616967
86MP0002064_seizures0.74431501
87MP0002733_abnormal_thermal_nociception0.74397131
88MP0002282_abnormal_trachea_morphology0.73953787
89MP0006036_abnormal_mitochondrial_physio0.72745191
90MP0001502_abnormal_circadian_rhythm0.72698824
91MP0005266_abnormal_metabolism0.72049863
92MP0001970_abnormal_pain_threshold0.70676718
93MP0009643_abnormal_urine_homeostasis0.70001897
94MP0003698_abnormal_male_reproductive0.69898867
95MP0001293_anophthalmia0.69719882
96MP0003786_premature_aging0.69116735
97MP0003567_abnormal_fetal_cardiomyocyte0.68661642
98MP0000609_abnormal_liver_physiology0.68486440
99MP0000427_abnormal_hair_cycle0.68074955
100MP0005379_endocrine/exocrine_gland_phen0.67170997

Predicted human phenotypes

RankGene SetZ-score
1Complement deficiency (HP:0004431)4.64773427
2Prolonged partial thromboplastin time (HP:0003645)4.12416041
3Abnormality of aromatic amino acid family metabolism (HP:0004338)4.12365427
4True hermaphroditism (HP:0010459)3.92259846
5Conjugated hyperbilirubinemia (HP:0002908)3.61381283
6Abnormality of monocarboxylic acid metabolism (HP:0010996)3.44712152
7Hyperglycinemia (HP:0002154)3.30307761
8Hyperlipoproteinemia (HP:0010980)3.29427372
9Pancreatic cysts (HP:0001737)3.26664296
10Pancreatic fibrosis (HP:0100732)3.19503222
11Abnormality of complement system (HP:0005339)3.16752909
12Molar tooth sign on MRI (HP:0002419)3.15929958
13Abnormality of midbrain morphology (HP:0002418)3.15929958
14Chronic hepatic failure (HP:0100626)3.03517917
15Type II lissencephaly (HP:0007260)3.01619395
16Male pseudohermaphroditism (HP:0000037)2.98729787
17Hyperventilation (HP:0002883)2.96487686
18Hypobetalipoproteinemia (HP:0003563)2.96434024
19Fair hair (HP:0002286)2.95400681
20Congenital stationary night blindness (HP:0007642)2.87975562
21Abnormality of the renal cortex (HP:0011035)2.77107856
22Abnormality of glycine metabolism (HP:0010895)2.76165534
23Abnormality of serine family amino acid metabolism (HP:0010894)2.76165534
24Ketosis (HP:0001946)2.74575732
25Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.70782019
26Abnormality of alanine metabolism (HP:0010916)2.70782019
27Hyperalaninemia (HP:0003348)2.70782019
28Abolished electroretinogram (ERG) (HP:0000550)2.61583346
29Systemic lupus erythematosus (HP:0002725)2.60046290
30Nephronophthisis (HP:0000090)2.57256223
31Deep venous thrombosis (HP:0002625)2.46856696
32Medial flaring of the eyebrow (HP:0010747)2.45582861
33Abnormality of urine glucose concentration (HP:0011016)2.43422654
34Glycosuria (HP:0003076)2.43422654
35Hyperglycinuria (HP:0003108)2.42529867
36Joint hemorrhage (HP:0005261)2.41317088
37Abnormality of serum amino acid levels (HP:0003112)2.41202245
38Bile duct proliferation (HP:0001408)2.40957630
39Abnormal biliary tract physiology (HP:0012439)2.40957630
40Abnormality of aspartate family amino acid metabolism (HP:0010899)2.40712977
41Pendular nystagmus (HP:0012043)2.39791913
42Abnormality of methionine metabolism (HP:0010901)2.39181618
43Delayed CNS myelination (HP:0002188)2.26512145
44Renal cortical cysts (HP:0000803)2.24513235
45Arthropathy (HP:0003040)2.24270185
46Abnormality of the renal medulla (HP:0100957)2.23554864
47Abnormal rod and cone electroretinograms (HP:0008323)2.18447301
48Xanthomatosis (HP:0000991)2.18035351
49Attenuation of retinal blood vessels (HP:0007843)2.15702762
50Intrahepatic cholestasis (HP:0001406)2.15048254
51Generalized aminoaciduria (HP:0002909)2.14827952
52Gonadal dysgenesis (HP:0000133)2.14167462
53Abnormality of the labia minora (HP:0012880)2.10104684
54Gait imbalance (HP:0002141)2.09273963
55Tubular atrophy (HP:0000092)2.08980890
56Epidermoid cyst (HP:0200040)2.07708753
57Methylmalonic acidemia (HP:0002912)2.07334881
58Nephrogenic diabetes insipidus (HP:0009806)2.06963120
59Abnormality of sulfur amino acid metabolism (HP:0004339)2.06853556
60Cystic liver disease (HP:0006706)2.06745428
61Absent rod-and cone-mediated responses on ERG (HP:0007688)2.06516275
62Congenital primary aphakia (HP:0007707)2.05694355
63Decreased central vision (HP:0007663)2.05290518
64Acute encephalopathy (HP:0006846)2.04607743
65Keratoconus (HP:0000563)2.04470275
66Increased corneal curvature (HP:0100692)2.04470275
67Generalized hypopigmentation of hair (HP:0011358)2.03784595
68Mitochondrial inheritance (HP:0001427)2.03061260
69Hyperphosphaturia (HP:0003109)2.02693949
70Cerebellar dysplasia (HP:0007033)2.02410850
71Spontaneous abortion (HP:0005268)2.00280738
72Lethargy (HP:0001254)1.98214750
73Decreased electroretinogram (ERG) amplitude (HP:0000654)1.97236621
74Increased CSF lactate (HP:0002490)1.96635910
75Metabolic acidosis (HP:0001942)1.96119445
76Abnormality of pyrimidine metabolism (HP:0004353)1.96103821
77Hypothermia (HP:0002045)1.95270154
78Hyperammonemia (HP:0001987)1.94964383
79Recurrent gram-negative bacterial infections (HP:0005420)1.93939554
80Ketoacidosis (HP:0001993)1.93484075
813-Methylglutaconic aciduria (HP:0003535)1.92944800
82Lissencephaly (HP:0001339)1.89084129
83Abnormal drinking behavior (HP:0030082)1.87480825
84Polydipsia (HP:0001959)1.87480825
85Retinal dysplasia (HP:0007973)1.86516479
86Methylmalonic aciduria (HP:0012120)1.85234250
87Congenital hepatic fibrosis (HP:0002612)1.83217827
88Inability to walk (HP:0002540)1.82790063
89Acute necrotizing encephalopathy (HP:0006965)1.80137321
90Occipital encephalocele (HP:0002085)1.78992522
91Abnormality of the intrinsic pathway (HP:0010989)1.78766639
92Retinal atrophy (HP:0001105)1.77624355
93Pachygyria (HP:0001302)1.77509623
94Hepatic necrosis (HP:0002605)1.77136659
95Increased serum lactate (HP:0002151)1.76769741
96Mesangial abnormality (HP:0001966)1.76582663
97Cerebral edema (HP:0002181)1.76236151
98Aplasia/Hypoplasia of the tongue (HP:0010295)1.75769704
99Glomerulonephritis (HP:0000099)1.75257271
100Aplasia/Hypoplasia of the tibia (HP:0005772)1.73637722

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.51203019
2MAP4K24.05449364
3PINK13.16327284
4ZAK2.94283612
5ADRBK22.49316164
6WNK32.38230063
7GRK12.17934606
8NUAK12.15120160
9CAMKK22.13462292
10TRIM281.98773249
11BMPR1B1.94218552
12TXK1.90511074
13BCKDK1.88265289
14TAOK31.88140157
15MAPK131.86200457
16WNK41.73560602
17TLK11.62271750
18CSNK1G11.53095528
19CSNK1G31.47664217
20TNIK1.46759206
21TIE11.46744259
22INSRR1.42994555
23NLK1.41768621
24STK391.39780484
25OXSR11.39286803
26DAPK21.37064928
27CSNK1G21.36826393
28MAP3K41.36513507
29CSNK1A1L1.31683095
30PAK31.29763796
31MST41.27911942
32EIF2AK31.18516869
33PRKCE1.16173489
34CASK1.12808690
35TNK21.08455321
36VRK21.07624125
37DYRK21.07046083
38BRSK21.02873324
39EPHA41.02041736
40NTRK30.97090192
41ADRBK10.91944237
42BCR0.90706539
43MAP2K70.90511048
44PLK20.89896161
45AKT30.88130622
46PRKCG0.85676150
47FER0.82060774
48TEC0.81380234
49VRK10.80864598
50PRKCQ0.78653653
51NTRK20.76553853
52ERBB30.75611661
53CSNK1A10.72928781
54MKNK20.72738555
55ACVR1B0.72461202
56PRKACA0.66744308
57MAP2K60.63855380
58STK38L0.62567573
59MARK10.61749763
60PDK20.60958692
61MUSK0.60443388
62STK110.58537460
63MAPKAPK30.56881748
64EPHA30.56860351
65FGFR20.55793617
66PRKCI0.55304013
67PRKAA20.55262123
68KDR0.54215862
69IKBKB0.53063141
70PHKG20.52214819
71PHKG10.52214819
72RPS6KA50.51966637
73CAMKK10.51929360
74CAMK10.51356782
75ITK0.51301544
76DYRK1A0.51117387
77PKN10.50451383
78SGK20.50370115
79PRKCA0.49403817
80DAPK10.49102319
81PRKACG0.48794016
82PRKAA10.47873613
83CAMK2A0.45875729
84IRAK10.45142824
85PRKCZ0.44317306
86CDK190.43327666
87GRK50.43297351
88CSNK1D0.43046997
89IGF1R0.42893159
90TAF10.42836012
91PTK2B0.42286916
92PIK3CA0.42103142
93MKNK10.41177132
94ERBB20.40098785
95SGK4940.38736229
96SGK2230.38736229
97PRKG10.37892424
98KIT0.37720523
99MAPKAPK50.35059114
100MYLK0.33979608

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002323.88516773
2Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.04654314
3Primary bile acid biosynthesis_Homo sapiens_hsa001202.98967611
4Retinol metabolism_Homo sapiens_hsa008302.91568735
5Linoleic acid metabolism_Homo sapiens_hsa005912.81962546
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.74875501
7Chemical carcinogenesis_Homo sapiens_hsa052042.69049495
8Butanoate metabolism_Homo sapiens_hsa006502.62000054
9Complement and coagulation cascades_Homo sapiens_hsa046102.52739541
10Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.44155403
11Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.40181956
12Steroid hormone biosynthesis_Homo sapiens_hsa001402.32051433
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.28304538
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.26682145
15Tryptophan metabolism_Homo sapiens_hsa003802.26361078
16Fatty acid degradation_Homo sapiens_hsa000712.24257845
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.22246926
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.07128751
19Pentose and glucuronate interconversions_Homo sapiens_hsa000401.89781031
20Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.78691600
21Histidine metabolism_Homo sapiens_hsa003401.77738778
22Propanoate metabolism_Homo sapiens_hsa006401.69408462
23Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.58784974
24Tyrosine metabolism_Homo sapiens_hsa003501.57501333
25Peroxisome_Homo sapiens_hsa041461.54605801
26beta-Alanine metabolism_Homo sapiens_hsa004101.52920260
27alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.52786888
28Drug metabolism - other enzymes_Homo sapiens_hsa009831.51450752
29Arachidonic acid metabolism_Homo sapiens_hsa005901.46713647
30One carbon pool by folate_Homo sapiens_hsa006701.45713458
31Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.37921362
32Selenocompound metabolism_Homo sapiens_hsa004501.31457950
33Arginine biosynthesis_Homo sapiens_hsa002201.29807189
34Phototransduction_Homo sapiens_hsa047441.29365004
35Phenylalanine metabolism_Homo sapiens_hsa003601.24409867
36Maturity onset diabetes of the young_Homo sapiens_hsa049501.22786926
37Cysteine and methionine metabolism_Homo sapiens_hsa002701.22432444
38Nitrogen metabolism_Homo sapiens_hsa009101.19152999
39Cyanoamino acid metabolism_Homo sapiens_hsa004601.13864404
40Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.09422066
41Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.08933993
42Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.04849061
43Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.02286920
44ABC transporters_Homo sapiens_hsa020101.01479899
45Protein export_Homo sapiens_hsa030600.98458142
46Sulfur metabolism_Homo sapiens_hsa009200.97223330
47Sulfur relay system_Homo sapiens_hsa041220.94019716
48Bile secretion_Homo sapiens_hsa049760.93197165
49Pyruvate metabolism_Homo sapiens_hsa006200.91270915
50Fat digestion and absorption_Homo sapiens_hsa049750.89297798
51Ether lipid metabolism_Homo sapiens_hsa005650.89251223
52Starch and sucrose metabolism_Homo sapiens_hsa005000.88614753
53Oxidative phosphorylation_Homo sapiens_hsa001900.88220894
54Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.87106693
55Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.84086609
56Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.82319157
57Arginine and proline metabolism_Homo sapiens_hsa003300.81085192
58PPAR signaling pathway_Homo sapiens_hsa033200.80321789
59Fatty acid metabolism_Homo sapiens_hsa012120.79559170
60Regulation of autophagy_Homo sapiens_hsa041400.78329909
61Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.77968346
62Nicotine addiction_Homo sapiens_hsa050330.75078042
63Staphylococcus aureus infection_Homo sapiens_hsa051500.72758813
64Metabolic pathways_Homo sapiens_hsa011000.68777142
65Steroid biosynthesis_Homo sapiens_hsa001000.67831186
66Ovarian steroidogenesis_Homo sapiens_hsa049130.59123164
67Fatty acid elongation_Homo sapiens_hsa000620.57440562
68Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.52194494
69Parkinsons disease_Homo sapiens_hsa050120.51183446
70Glycerolipid metabolism_Homo sapiens_hsa005610.49327839
71Basal transcription factors_Homo sapiens_hsa030220.46658378
72Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.45749619
73Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.44899404
74Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.44402511
75Collecting duct acid secretion_Homo sapiens_hsa049660.42715971
76Vitamin B6 metabolism_Homo sapiens_hsa007500.41122162
77Serotonergic synapse_Homo sapiens_hsa047260.36842816
78RNA polymerase_Homo sapiens_hsa030200.36594446
79RNA degradation_Homo sapiens_hsa030180.36509404
80Vitamin digestion and absorption_Homo sapiens_hsa049770.35064403
81Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.34129090
82Primary immunodeficiency_Homo sapiens_hsa053400.33508872
83Mineral absorption_Homo sapiens_hsa049780.33052383
84Olfactory transduction_Homo sapiens_hsa047400.30168155
85GABAergic synapse_Homo sapiens_hsa047270.29879433
86Homologous recombination_Homo sapiens_hsa034400.28730822
87Glutathione metabolism_Homo sapiens_hsa004800.27378364
88Morphine addiction_Homo sapiens_hsa050320.26683162
89Lysine degradation_Homo sapiens_hsa003100.25914813
90Fanconi anemia pathway_Homo sapiens_hsa034600.25381006
91Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.25078008
92Proteasome_Homo sapiens_hsa030500.24489191
93Huntingtons disease_Homo sapiens_hsa050160.20151960
94Insulin secretion_Homo sapiens_hsa049110.19799692
95Taste transduction_Homo sapiens_hsa047420.19609120
96Folate biosynthesis_Homo sapiens_hsa007900.17892941
97Carbon metabolism_Homo sapiens_hsa012000.17686564
98Intestinal immune network for IgA production_Homo sapiens_hsa046720.17634922
99SNARE interactions in vesicular transport_Homo sapiens_hsa041300.17568311
100Prion diseases_Homo sapiens_hsa050200.12403998

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »