CLEC5A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type II transmembrane protein interacts with dnax-activation protein 12 and may play a role in cell activation. Alternative splice variants have been described but their full-length sequence has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to peptidoglycan (GO:0032494)7.00950482
2neutrophil activation involved in immune response (GO:0002283)6.81700567
3modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.19056898
4modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.19056898
5positive regulation by organism of defense response of other organism involved in symbiotic interact6.19056898
6modulation by symbiont of host immune response (GO:0052553)6.19056898
7positive regulation by symbiont of host defense response (GO:0052509)6.19056898
8modulation by symbiont of host defense response (GO:0052031)6.19056898
9respiratory burst (GO:0045730)6.02930328
10leukocyte aggregation (GO:0070486)5.49016880
11regulation of vitamin D biosynthetic process (GO:0060556)5.32887510
12positive regulation of interleukin-8 biosynthetic process (GO:0045416)5.16103195
13neutrophil mediated immunity (GO:0002446)5.14295303
14reactive oxygen species biosynthetic process (GO:1903409)5.03899661
15antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.01208263
16hydrogen peroxide biosynthetic process (GO:0050665)4.90639847
17macrophage activation involved in immune response (GO:0002281)4.83007503
18granulocyte activation (GO:0036230)4.80825001
19neutrophil activation (GO:0042119)4.77984594
20superoxide anion generation (GO:0042554)4.72900075
21immunoglobulin mediated immune response (GO:0016064)4.69613127
22production of molecular mediator involved in inflammatory response (GO:0002532)4.66071475
23response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.61571688
24response to host immune response (GO:0052572)4.61571688
25monocyte chemotaxis (GO:0002548)4.51437426
26regulation of macrophage chemotaxis (GO:0010758)4.50112083
27eosinophil chemotaxis (GO:0048245)4.39239977
28cellular response to thyroid hormone stimulus (GO:0097067)4.38545576
29positive regulation of mast cell activation (GO:0033005)4.35312527
30response to fungus (GO:0009620)4.32251169
31cellular extravasation (GO:0045123)4.31514433
32leukocyte migration involved in inflammatory response (GO:0002523)4.30623232
33regulation of interferon-beta biosynthetic process (GO:0045357)4.24851028
34positive regulation of mast cell activation involved in immune response (GO:0033008)4.19356984
35positive regulation of mast cell degranulation (GO:0043306)4.19356984
36myeloid cell activation involved in immune response (GO:0002275)4.16742998
37regulation of vitamin metabolic process (GO:0030656)4.16736280
38microglial cell activation (GO:0001774)4.16353811
39negative regulation of growth of symbiont in host (GO:0044130)4.15908287
40negative regulation of growth of symbiont involved in interaction with host (GO:0044146)4.15908287
41modulation of growth of symbiont involved in interaction with host (GO:0044144)4.15908287
42regulation of growth of symbiont in host (GO:0044126)4.15908287
43positive regulation of heat generation (GO:0031652)4.15425062
44glycosphingolipid catabolic process (GO:0046479)4.12547953
45response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.10901383
46response to host (GO:0075136)4.10901383
47response to host defenses (GO:0052200)4.10901383
48regulation of mast cell activation (GO:0033003)4.07140509
49regulation of podosome assembly (GO:0071801)4.05558000
50lipopolysaccharide-mediated signaling pathway (GO:0031663)4.04606354
51disruption of cells of other organism involved in symbiotic interaction (GO:0051818)4.03304787
52killing of cells in other organism involved in symbiotic interaction (GO:0051883)4.03304787
53eosinophil migration (GO:0072677)4.03054406
54leukocyte mediated cytotoxicity (GO:0001909)3.96592815
55regulation of fever generation (GO:0031620)3.95270977
56positive regulation of interferon-alpha production (GO:0032727)3.94802812
57regulation of mast cell degranulation (GO:0043304)3.92633608
58neutrophil chemotaxis (GO:0030593)3.90562118
59myeloid leukocyte mediated immunity (GO:0002444)3.89132151
60cellular response to cadmium ion (GO:0071276)3.88501424
61neutrophil migration (GO:1990266)3.79907041
62regulation of mast cell activation involved in immune response (GO:0033006)3.76120982
63regulation of B cell receptor signaling pathway (GO:0050855)3.75953616
64regulation of interferon-alpha production (GO:0032647)3.73846307
65oligosaccharide catabolic process (GO:0009313)3.72900292
66regulation of lymphocyte chemotaxis (GO:1901623)3.71719739
67sequestering of metal ion (GO:0051238)3.71336931
68positive regulation of chemokine biosynthetic process (GO:0045080)3.69973424
69cellular response to zinc ion (GO:0071294)3.69652645
70glycolipid catabolic process (GO:0019377)3.69300561
71macrophage activation (GO:0042116)3.58841263
72regulation of chemokine biosynthetic process (GO:0045073)3.58123934
73regulation of myeloid leukocyte mediated immunity (GO:0002886)3.57796764
74regulation of interleukin-8 biosynthetic process (GO:0045414)3.55474119
75defense response to fungus (GO:0050832)3.54373302
76regulation of leukocyte degranulation (GO:0043300)3.54311259
77positive regulation of cellular amide metabolic process (GO:0034250)3.54130807
78phagosome maturation (GO:0090382)3.53916111
79response to muramyl dipeptide (GO:0032495)3.53002631
80cellular response to ethanol (GO:0071361)3.50217181
81B cell mediated immunity (GO:0019724)3.48142251
82positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.47291796
83regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.41922067
84granulocyte chemotaxis (GO:0071621)3.41134392
85macrophage differentiation (GO:0030225)3.41021717
86negative regulation of mast cell activation (GO:0033004)3.40305750
87positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.39934008
88negative regulation of interleukin-12 production (GO:0032695)3.39700021
89response to thyroid hormone (GO:0097066)3.37039623
90positive regulation of leukocyte degranulation (GO:0043302)3.34161101
91granulocyte migration (GO:0097530)3.33333858
92positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.32171098
93leukotriene metabolic process (GO:0006691)3.31662792
94leukocyte degranulation (GO:0043299)3.30348405
95detection of other organism (GO:0098543)3.28222676
96ceramide catabolic process (GO:0046514)3.27807175
97Arp2/3 complex-mediated actin nucleation (GO:0034314)3.27750581
98natural killer cell mediated cytotoxicity (GO:0042267)3.25596922
99natural killer cell mediated immunity (GO:0002228)3.25596922
100barbed-end actin filament capping (GO:0051016)3.24395750
101NIK/NF-kappaB signaling (GO:0038061)3.23175473
102detection of molecule of bacterial origin (GO:0032490)3.20175274
103positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.18155337
104positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.17961626
105negative regulation of interleukin-17 production (GO:0032700)3.16240366
106regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.15589021
107positive regulation of gamma-delta T cell activation (GO:0046645)3.12611046
108myeloid leukocyte activation (GO:0002274)3.12011270
109regulation of heat generation (GO:0031650)3.11716407
110positive regulation of monocyte chemotaxis (GO:0090026)3.09946436
111cellular response to lipopolysaccharide (GO:0071222)3.09264469
112negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.08887528
113T-helper 1 type immune response (GO:0042088)3.08108402
114positive regulation of NF-kappaB import into nucleus (GO:0042346)3.07875411
115positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.06908397
116amino sugar catabolic process (GO:0046348)3.04596926
117membrane lipid catabolic process (GO:0046466)3.04139075
118negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.03872440
119negative regulation of cell killing (GO:0031342)3.03872440
120regulation of mononuclear cell migration (GO:0071675)3.03667672
121positive regulation of antigen processing and presentation (GO:0002579)3.03654667
122cellular response to molecule of bacterial origin (GO:0071219)3.02958292
123positive regulation of interferon-beta production (GO:0032728)3.02387378
124negative regulation of cytokine production involved in immune response (GO:0002719)3.00716019
125regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.00527029
126cell killing (GO:0001906)3.00446007
127regulation of cytokine secretion involved in immune response (GO:0002739)2.99550214
128mast cell activation (GO:0045576)2.99536813
129positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.97896144
130lymphocyte chemotaxis (GO:0048247)2.97567680
131germinal center formation (GO:0002467)2.96972201
132leukocyte cell-cell adhesion (GO:0007159)2.95230056
133killing of cells of other organism (GO:0031640)2.93083679
134disruption of cells of other organism (GO:0044364)2.93083679
135regulation of lymphocyte migration (GO:2000401)2.91360112
136regulation of vascular endothelial growth factor production (GO:0010574)2.90010891
137regulation of regulated secretory pathway (GO:1903305)2.89448232
138regulation of membrane protein ectodomain proteolysis (GO:0051043)2.89297708
139positive regulation of toll-like receptor signaling pathway (GO:0034123)2.87784247
140positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.87334921
141myeloid dendritic cell differentiation (GO:0043011)2.87058987
142positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.86619310
143positive regulation of interleukin-6 production (GO:0032755)2.86273165
144detection of external biotic stimulus (GO:0098581)2.86270874
145positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.86228065
146decidualization (GO:0046697)2.84887934
147negative regulation of nitric oxide biosynthetic process (GO:0045019)2.80219092
148positive regulation of acute inflammatory response (GO:0002675)2.79145932
149N-acetylneuraminate metabolic process (GO:0006054)2.78225448

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human7.72879124
2IRF8_21731497_ChIP-ChIP_J774_Mouse6.89752353
3IRF8_22096565_ChIP-ChIP_GC-B_Human5.52331906
4IRF8_27001747_Chip-Seq_BMDM_Mouse4.55030112
5* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse4.39396351
6MYB_21317192_ChIP-Seq_ERMYB_Mouse4.08944839
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse4.04063083
8NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.90017683
9EGR1_19374776_ChIP-ChIP_THP-1_Human3.63570152
10Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.54103042
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.40108720
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.06356693
13E2F7_22180533_ChIP-Seq_HELA_Human2.99105285
14IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.92396204
15NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.90904314
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.90856382
17BRD4_27068464_Chip-Seq_AML-cells_Mouse2.78427467
18SPI1_23547873_ChIP-Seq_NB4_Human2.73003366
19FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.72905418
20STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.65072626
21STAT6_21828071_ChIP-Seq_BEAS2B_Human2.54665577
22RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.38557540
23STAT4_19710469_ChIP-ChIP_TH1__Mouse2.29855420
24VDR_24763502_ChIP-Seq_THP-1_Human2.12058293
25RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.07915077
26SCL_19346495_ChIP-Seq_HPC-7_Human2.06413455
27RUNX1_22412390_ChIP-Seq_EML_Mouse1.97808136
28PU_27001747_Chip-Seq_BMDM_Mouse1.93636692
29SPI1_23127762_ChIP-Seq_K562_Human1.91907509
30PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.91397851
31VDR_21846776_ChIP-Seq_THP-1_Human1.88796568
32FOXM1_23109430_ChIP-Seq_U2OS_Human1.82786242
33SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.82713388
34* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.80379020
35ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.79312044
36GATA1_22025678_ChIP-Seq_K562_Human1.76386228
37MYB_26560356_Chip-Seq_TH2_Human1.75989280
38CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.72363371
39NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.71211201
40MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.67148278
41VDR_24787735_ChIP-Seq_THP-1_Human1.66135994
42* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.56253223
43STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.54980165
44FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.53994638
45MAF_26560356_Chip-Seq_TH1_Human1.51150925
46RUNX_20019798_ChIP-Seq_JUKART_Human1.50747877
47VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.49517502
48CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.48781001
49* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.48530891
50PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.48328253
51CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.46650156
52LXR_22292898_ChIP-Seq_THP-1_Human1.46386783
53KDM2B_26808549_Chip-Seq_SUP-B15_Human1.46334033
54MYB_26560356_Chip-Seq_TH1_Human1.36120055
55PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.32272633
56* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.29725445
57UTX_26944678_Chip-Seq_JUKART_Human1.29324167
58NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.29322240
59PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.29287584
60GATA2_22383799_ChIP-Seq_G1ME_Mouse1.25223328
61GATA3_26560356_Chip-Seq_TH2_Human1.19611980
62LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.19452113
63GATA1_19941826_ChIP-Seq_K562_Human1.16907654
64SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.15653980
65KDM2B_26808549_Chip-Seq_DND41_Human1.13389210
66GATA3_27048872_Chip-Seq_THYMUS_Human1.11266519
67STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.11076319
68GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.08038308
69E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.07047919
70KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.05418037
71THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.98499187
72CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.97496968
73GATA1_22383799_ChIP-Seq_G1ME_Mouse0.96607210
74BCL6_27268052_Chip-Seq_Bcells_Human0.95761526
75ESR2_21235772_ChIP-Seq_MCF-7_Human0.95470025
76HOXB4_20404135_ChIP-ChIP_EML_Mouse0.94100189
77GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92902796
78GATA2_21666600_ChIP-Seq_HMVEC_Human0.92158326
79BCOR_27268052_Chip-Seq_Bcells_Human0.92058013
80PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.91708459
81STAT1_20625510_ChIP-Seq_HELA_Human0.91569570
82TCF7_22412390_ChIP-Seq_EML_Mouse0.90458043
83SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.88774238
84GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88086994
85TFEB_21752829_ChIP-Seq_HELA_Human0.88015947
86SPI1_20517297_ChIP-Seq_HL60_Human0.86911106
87* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.85024724
88RARG_19884340_ChIP-ChIP_MEFs_Mouse0.82812401
89IKZF1_21737484_ChIP-ChIP_HCT116_Human0.82759018
90CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.81725503
91CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.78490367
92* TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.77989951
93RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.77570894
94KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.77357119
95TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.76854175
96JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.76681801
97NCOR1_26117541_ChIP-Seq_K562_Human0.76668204
98GATA1_19941827_ChIP-Seq_MEL_Mouse0.76336037
99TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.76279030
100VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.74848486
101E2F4_17652178_ChIP-ChIP_JURKAT_Human0.74568635
102SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74504965
103GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73273563
104MAF_26560356_Chip-Seq_TH2_Human0.72994465
105ERG_20887958_ChIP-Seq_HPC-7_Mouse0.72590952
106GATA2_19941826_ChIP-Seq_K562_Human0.68893951
107PU.1_20513432_ChIP-Seq_Bcells_Mouse0.67676944
108MYC_22102868_ChIP-Seq_BL_Human0.67336247
109RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.66104563
110ELF1_17652178_ChIP-ChIP_JURKAT_Human0.65906944
111ELK3_25401928_ChIP-Seq_HUVEC_Human0.64155486
112TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.61402563
113CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.59298116
114MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.56767134
115SMAD_19615063_ChIP-ChIP_OVARY_Human0.55945726
116ELK1_19687146_ChIP-ChIP_HELA_Human0.55339117
117EGR1_19032775_ChIP-ChIP_M12_Human0.55080909
118JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.54939258
119ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.53265426
120SOX2_20726797_ChIP-Seq_SW620_Human0.53133610

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0003436_decreased_susceptibility_to4.22293530
2MP0001835_abnormal_antigen_presentation4.20510773
3MP0009785_altered_susceptibility_to4.06319456
4MP0003303_peritoneal_inflammation4.00807508
5MP0002419_abnormal_innate_immunity3.81901013
6MP0002148_abnormal_hypersensitivity_rea3.58430664
7* MP0005000_abnormal_immune_tolerance3.13138206
8MP0005025_abnormal_response_to3.10156678
9MP0006082_CNS_inflammation2.99754546
10MP0005058_abnormal_lysosome_morphology2.98437697
11MP0003724_increased_susceptibility_to2.83786560
12MP0002452_abnormal_antigen_presenting2.65786474
13MP0003172_abnormal_lysosome_physiology2.65781517
14MP0005464_abnormal_platelet_physiology2.52496541
15MP0002723_abnormal_immune_serum2.41190053
16MP0001800_abnormal_humoral_immune2.35090817
17MP0000343_altered_response_to2.32555350
18MP0005671_abnormal_response_to2.32167450
19MP0001819_abnormal_immune_cell2.30871355
20MP0002420_abnormal_adaptive_immunity2.29872689
21MP0005387_immune_system_phenotype2.28382622
22MP0001790_abnormal_immune_system2.28382622
23* MP0001533_abnormal_skeleton_physiology2.28341539
24MP0002139_abnormal_hepatobiliary_system2.19771454
25MP0009278_abnormal_bone_marrow2.10650259
26MP0002405_respiratory_system_inflammati2.05613619
27MP0001845_abnormal_inflammatory_respons2.05335213
28MP0001853_heart_inflammation2.03157086
29MP0003183_abnormal_peptide_metabolism2.01650180
30MP0000685_abnormal_immune_system2.00281032
31MP0003075_altered_response_to1.93883014
32MP0009764_decreased_sensitivity_to1.92483916
33MP0003806_abnormal_nucleotide_metabolis1.87176589
34MP0003448_altered_tumor_morphology1.84694335
35MP0000858_altered_metastatic_potential1.77862436
36MP0008469_abnormal_protein_level1.67443334
37MP0004510_myositis1.67343401
38MP0002006_tumorigenesis1.64999416
39MP0004947_skin_inflammation1.64089622
40MP0010155_abnormal_intestine_physiology1.59901586
41MP0005397_hematopoietic_system_phenotyp1.59766665
42MP0001545_abnormal_hematopoietic_system1.59766665
43MP0000716_abnormal_immune_system1.59591168
44MP0002837_dystrophic_cardiac_calcinosis1.58030304
45MP0005167_abnormal_blood-brain_barrier1.57303550
46MP0003191_abnormal_cellular_cholesterol1.53156149
47MP0005451_abnormal_body_composition1.49377902
48MP0002398_abnormal_bone_marrow1.48822595
49MP0000569_abnormal_digit_pigmentation1.46572917
50MP0005166_decreased_susceptibility_to1.41239122
51MP0009333_abnormal_splenocyte_physiolog1.40566642
52MP0002998_abnormal_bone_remodeling1.39489739
53MP0001851_eye_inflammation1.33507659
54MP0003828_pulmonary_edema1.32969973
55MP0005310_abnormal_salivary_gland1.31675528
56MP0002429_abnormal_blood_cell1.31443364
57MP0002166_altered_tumor_susceptibility1.29260349
58MP0000689_abnormal_spleen_morphology1.28879258
59MP0005164_abnormal_response_to1.27104722
60MP0000604_amyloidosis1.27020709
61MP0002254_reproductive_system_inflammat1.26148183
62MP0003300_gastrointestinal_ulcer1.26069820
63MP0005076_abnormal_cell_differentiation1.23096213
64MP0003690_abnormal_glial_cell1.21268533
65MP0002722_abnormal_immune_system1.18635855
66MP0003186_abnormal_redox_activity1.17875141
67MP0002277_abnormal_respiratory_mucosa1.14247742
68MP0010307_abnormal_tumor_latency1.13627311
69MP0003329_amyloid_beta_deposits1.12074787
70MP0000465_gastrointestinal_hemorrhage1.05600248
71MP0002396_abnormal_hematopoietic_system1.05463948
72MP0005174_abnormal_tail_pigmentation1.04645147
73MP0003656_abnormal_erythrocyte_physiolo1.04159259
74MP0002877_abnormal_melanocyte_morpholog1.00881653
75MP0009763_increased_sensitivity_to1.00739199
76MP0004883_abnormal_blood_vessel1.00108254
77MP0003566_abnormal_cell_adhesion0.99132521
78* MP0005390_skeleton_phenotype0.98809036
79MP0004782_abnormal_surfactant_physiolog0.98111242
80MP0002933_joint_inflammation0.97765008
81MP0004808_abnormal_hematopoietic_stem0.97550423
82MP0000490_abnormal_crypts_of0.91984095
83MP0009765_abnormal_xenobiotic_induced0.91375571
84MP0009840_abnormal_foam_cell0.88827276
85MP0000249_abnormal_blood_vessel0.84302260
86MP0004233_abnormal_muscle_weight0.84019526
87MP0001849_ear_inflammation0.80221148
88MP0008874_decreased_physiological_sensi0.79836554
89MP0003453_abnormal_keratinocyte_physiol0.79023979
90MP0005595_abnormal_vascular_smooth0.77798803
91MP0003091_abnormal_cell_migration0.76587421
92MP0003795_abnormal_bone_structure0.74850650
93MP0000920_abnormal_myelination0.74772107
94MP0002332_abnormal_exercise_endurance0.74753924
95MP0008873_increased_physiological_sensi0.74568509
96MP0003195_calcinosis0.72888453
97MP0005023_abnormal_wound_healing0.70576164
98MP0006054_spinal_hemorrhage0.69317756
99MP0000015_abnormal_ear_pigmentation0.68704328
100MP0003634_abnormal_glial_cell0.67345382
101MP0008260_abnormal_autophagy0.65312382
102MP0001663_abnormal_digestive_system0.65134649
103MP0002090_abnormal_vision0.63056418
104MP0005647_abnormal_sex_gland0.62257995
105MP0003866_abnormal_defecation0.60394575
106MP0000371_diluted_coat_color0.59587694
107MP0003633_abnormal_nervous_system0.57623262
108MP0002019_abnormal_tumor_incidence0.57057179
109MP0003763_abnormal_thymus_physiology0.57036502
110MP0005319_abnormal_enzyme/_coenzyme0.56980839
111MP0001958_emphysema0.56262900
112MP0000750_abnormal_muscle_regeneration0.56260923
113MP0002896_abnormal_bone_mineralization0.55248054
114MP0002138_abnormal_hepatobiliary_system0.55244149
115MP0001542_abnormal_bone_strength0.54899656
116MP0000703_abnormal_thymus_morphology0.53964700
117MP0001873_stomach_inflammation0.51739716
118MP0008004_abnormal_stomach_pH0.50528262
119MP0010352_gastrointestinal_tract_polyps0.50399335
120MP0002136_abnormal_kidney_physiology0.47956530
121MP0005165_increased_susceptibility_to0.46064161
122MP0003279_aneurysm0.45015249
123MP0000767_abnormal_smooth_muscle0.44929312

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)9.06710624
2Eczematoid dermatitis (HP:0000976)8.26126723
3Recurrent bacterial skin infections (HP:0005406)8.05277662
4Recurrent gram-negative bacterial infections (HP:0005420)7.44004244
5Abnormality of macrophages (HP:0004311)5.59424705
6Mediastinal lymphadenopathy (HP:0100721)5.41206794
7Obstructive lung disease (HP:0006536)5.23950481
8Chronic obstructive pulmonary disease (HP:0006510)5.23950481
9Gingivitis (HP:0000230)4.97690416
10Recurrent skin infections (HP:0001581)4.68313050
11Stomatitis (HP:0010280)4.57871795
12Systemic lupus erythematosus (HP:0002725)4.42892884
13Vacuolated lymphocytes (HP:0001922)4.32867289
14Loss of speech (HP:0002371)4.20413845
15Mutism (HP:0002300)4.10833061
16Increased cerebral lipofuscin (HP:0011813)4.03991636
17Increased neuronal autofluorescent lipopigment (HP:0002074)3.99210525
18Myositis (HP:0100614)3.96620465
19Recurrent fungal infections (HP:0002841)3.89132626
20Neurofibrillary tangles (HP:0002185)3.67934205
21Elevated erythrocyte sedimentation rate (HP:0003565)3.66605481
22Orchitis (HP:0100796)3.56838121
23Autoimmune thrombocytopenia (HP:0001973)3.54495555
24Periodontitis (HP:0000704)3.50445094
25Urticaria (HP:0001025)3.44106387
26Cellulitis (HP:0100658)3.43957704
27Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.43225564
28Optic neuritis (HP:0100653)3.27833825
29Retrobulbar optic neuritis (HP:0100654)3.27833825
30Metaphyseal irregularity (HP:0003025)3.24345701
31Disinhibition (HP:0000734)3.23975674
32Axonal loss (HP:0003447)3.23007083
33Prostate neoplasm (HP:0100787)3.18634644
34Glomerulonephritis (HP:0000099)3.18365141
35Abnormality of the vasculature of the conjunctiva (HP:0008054)3.10598545
36Agnosia (HP:0010524)3.10236567
37Meningitis (HP:0001287)3.09476798
38Increased serum ferritin (HP:0003281)3.07503653
39Abnormality of glycolipid metabolism (HP:0010969)3.06381140
40Abnormality of liposaccharide metabolism (HP:0010968)3.06381140
41Abnormality of glycosphingolipid metabolism (HP:0004343)3.06381140
42Vasculitis (HP:0002633)3.03004633
43Dysostosis multiplex (HP:0000943)3.00803406
44Pustule (HP:0200039)2.96964100
45Amyloidosis (HP:0011034)2.94044121
46Recurrent pneumonia (HP:0006532)2.92577812
47Recurrent viral infections (HP:0004429)2.90857825
48Basal ganglia calcification (HP:0002135)2.88861447
49Nuclear cataract (HP:0100018)2.80470382
50Osteomyelitis (HP:0002754)2.79338153
51Diminished motivation (HP:0000745)2.68962537
52Pulmonary infiltrates (HP:0002113)2.68288561
53Leukocytosis (HP:0001974)2.65884340
54Neuronal loss in central nervous system (HP:0002529)2.65835018
55Thick nail (HP:0001805)2.65254543
56Cerebral inclusion bodies (HP:0100314)2.65185003
57Chronic mucocutaneous candidiasis (HP:0002728)2.63955647
58Recurrent cutaneous fungal infections (HP:0011370)2.63955647
59Abnormality of the prostate (HP:0008775)2.62594277
60Apathy (HP:0000741)2.62358498
61Hepatosplenomegaly (HP:0001433)2.62163429
62Interstitial pulmonary disease (HP:0006530)2.61583156
63Mucopolysacchariduria (HP:0008155)2.57932389
64Urinary glycosaminoglycan excretion (HP:0003541)2.57932389
65Petechiae (HP:0000967)2.57479357
66Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.56231238
67Papilledema (HP:0001085)2.53621191
68Spontaneous hematomas (HP:0007420)2.49004192
69Retinal atrophy (HP:0001105)2.44112555
70Abnormality of mucopolysaccharide metabolism (HP:0011020)2.42937767
71Abnormality of polysaccharide metabolism (HP:0011012)2.42937767
72Abnormality of glycosaminoglycan metabolism (HP:0004371)2.42937767
73Abnormality of iron homeostasis (HP:0011031)2.37733501
74Eosinophilia (HP:0001880)2.37510105
75Inappropriate behavior (HP:0000719)2.37118035
76Recurrent lower respiratory tract infections (HP:0002783)2.37055825
77Progressive neurologic deterioration (HP:0002344)2.30251235
78Keratoconjunctivitis sicca (HP:0001097)2.29459926
79Hemoptysis (HP:0002105)2.26843713
80Sepsis (HP:0100806)2.25669732
81Malnutrition (HP:0004395)2.24068119
82Increased IgM level (HP:0003496)2.23146492
83Conjunctival telangiectasia (HP:0000524)2.21108623
84Joint hemorrhage (HP:0005261)2.19652394
85Arterial thrombosis (HP:0004420)2.17474216
86Gingival bleeding (HP:0000225)2.16602369
87Hypergammaglobulinemia (HP:0010702)2.13886711
88Skin ulcer (HP:0200042)2.12607653
89Thoracic kyphosis (HP:0002942)2.10041833
90Thrombocytosis (HP:0001894)2.09773677
91Dementia (HP:0000726)2.08250772
92Personality changes (HP:0000751)2.08243089
93Polyneuropathy (HP:0001271)2.07523593
94Keratoconjunctivitis (HP:0001096)2.07415983
95Nephritis (HP:0000123)2.06672354
96Hematochezia (HP:0002573)2.05988075
97Abnormality of the periventricular white matter (HP:0002518)2.02847358
98Premature loss of primary teeth (HP:0006323)2.02357982
99Granulocytopenia (HP:0001913)2.02013525
100Osteolytic defects of the phalanges of the hand (HP:0009771)2.01285264
101Osteolytic defects of the hand bones (HP:0009699)2.01285264
102Epistaxis (HP:0000421)1.99708830
103Prolonged neonatal jaundice (HP:0006579)1.98474679
104Upper motor neuron abnormality (HP:0002127)1.98215705
105Asymmetric septal hypertrophy (HP:0001670)1.96720329
106Abnormality of the pleura (HP:0002103)1.95974943
107Chest pain (HP:0100749)1.94107441
108Thin bony cortex (HP:0002753)1.93128607
109Abnormality of transition element cation homeostasis (HP:0011030)1.92046245
110IgM deficiency (HP:0002850)1.91086882
111Complement deficiency (HP:0004431)1.91043254
112Pathologic fracture (HP:0002756)1.89893666
113Myocardial infarction (HP:0001658)1.89270762
114J-shaped sella turcica (HP:0002680)1.88561254
115Abnormality of eosinophils (HP:0001879)1.87190838
116Cheilitis (HP:0100825)1.86081878
117Tetraparesis (HP:0002273)1.84969205
118Progressive visual loss (HP:0000529)1.81551334
119Nausea (HP:0002018)1.81254060
120Global brain atrophy (HP:0002283)1.80905835
121Supranuclear gaze palsy (HP:0000605)1.80504717
122Abnormality of complement system (HP:0005339)1.80277654
123Peripheral demyelination (HP:0011096)1.79337434
124T lymphocytopenia (HP:0005403)1.77049991
125Abnormality of the lumbar spine (HP:0100712)1.76728057
126Gangrene (HP:0100758)1.76163243
127Memory impairment (HP:0002354)1.76133678
128Spondylolisthesis (HP:0003302)1.73417041
129Increased CSF protein (HP:0002922)1.73073318
130Bone pain (HP:0002653)1.73050434
131Chronic otitis media (HP:0000389)1.72755544
132Abnormality of T cell physiology (HP:0011840)1.72624243
133Gastrointestinal infarctions (HP:0005244)1.72508694
134Protuberant abdomen (HP:0001538)1.71778689
135Poor head control (HP:0002421)1.71180373
136Purpura (HP:0000979)1.67568635
137Anorexia (HP:0002039)1.67121732

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.88877425
2IRAK44.74792371
3BLK4.52899263
4MAP3K143.36635179
5DDR22.97685606
6PBK2.74138182
7IRAK32.69997836
8TXK2.54090431
9TBK12.45658677
10TYK22.41950130
11MAP4K12.41013991
12CSK2.05256697
13KIT2.01090946
14ERN11.97072105
15TAOK21.94035029
16TESK11.83085896
17BTK1.82092537
18FES1.78625788
19IKBKE1.77012086
20TGFBR21.73036886
21FGR1.72419221
22TEC1.71942372
23PRPF4B1.68701175
24IKBKB1.66537275
25ACVR1B1.65721521
26HCK1.60181527
27NEK91.57069197
28CSF1R1.52466561
29SYK1.52180187
30LYN1.49638598
31TAOK11.49286327
32JAK31.45800250
33JAK11.45143186
34ZAP701.45118625
35CLK11.42866908
36STK101.42258579
37CDC42BPA1.41623623
38EPHB11.39933966
39GRK71.38780464
40TRPM71.38353408
41MAP2K31.34034951
42TESK21.18867003
43ERBB31.17273180
44STK41.12465888
45TAOK31.10233044
46MAP3K121.09714540
47JAK21.08453327
48MATK1.07932291
49RPS6KA41.06260653
50LCK1.05587774
51STK241.03169144
52EIF2AK21.02332733
53ITK1.00623344
54TYRO30.99213272
55ABL20.95742963
56PIM10.94922424
57PIM20.93162197
58IRAK20.91738365
59TGFBR10.91292687
60MAP3K10.89530009
61PRKCD0.89210792
62PAK40.84288371
63CAMK1G0.83640350
64ARAF0.81833750
65TTN0.80297852
66CHUK0.77499024
67RIPK10.77485002
68YES10.75738448
69BMPR20.71970888
70CAMKK20.69203539
71MARK30.68937512
72ABL10.64117231
73MAP3K130.64116009
74NME20.64044269
75DAPK20.62563372
76EGFR0.60187187
77ADRBK20.59760634
78IRAK10.59673476
79RPS6KA60.57768446
80EIF2AK30.57622797
81MST1R0.57492758
82PDGFRA0.55017957
83LIMK10.54086259
84BMX0.53284499
85MAPK40.53267487
86PIK3CG0.53172944
87MAP2K60.53134310
88GRK60.53030589
89MAP3K30.51923241
90RPS6KC10.49344086
91RPS6KL10.49344086
92BRSK20.49046141
93PDK20.46439828
94KSR20.46222948
95MAPKAPK20.45686435
96MAP3K50.45609308
97CDK60.44101381
98FYN0.42716454
99PDGFRB0.42264888
100FGFR30.41524998
101CAMK1D0.40868894
102SIK30.39828155
103PDK10.37912414
104PRKG20.37475939
105RPS6KA20.37329306
106SIK20.37108311
107KSR10.36930191
108LRRK20.35983970
109MST40.35931861
110MOS0.35037014
111TNK20.34959050
112MAP3K80.34887742
113PDPK10.34023402
114MAPK120.32529707
115ALK0.32220563
116MAP3K110.31375291
117ICK0.26592097
118IGF1R0.26581244
119NEK20.26156763
120LATS20.26007808
121EIF2AK10.25708843
122CDK40.25280254
123INSR0.24182683
124PRKCQ0.23900210
125KDR0.23868005
126CAMK40.23351263
127CDC70.22796306
128GSK3A0.20973508
129RPS6KA10.18362952
130CAMKK10.17531895
131MAPK110.17237708
132PTK60.17102665

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.92563206
2Staphylococcus aureus infection_Homo sapiens_hsa051503.85141186
3Legionellosis_Homo sapiens_hsa051342.82308686
4Toll-like receptor signaling pathway_Homo sapiens_hsa046202.67778685
5Osteoclast differentiation_Homo sapiens_hsa043802.64981159
6Graft-versus-host disease_Homo sapiens_hsa053322.60916414
7Pertussis_Homo sapiens_hsa051332.55908745
8Tuberculosis_Homo sapiens_hsa051522.52919141
9NOD-like receptor signaling pathway_Homo sapiens_hsa046212.34943958
10Phagosome_Homo sapiens_hsa041452.29347210
11NF-kappa B signaling pathway_Homo sapiens_hsa040642.27834115
12Lysosome_Homo sapiens_hsa041422.25546365
13Asthma_Homo sapiens_hsa053102.18769068
14Rheumatoid arthritis_Homo sapiens_hsa053232.12922500
15Malaria_Homo sapiens_hsa051442.04029373
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.98018558
17Salmonella infection_Homo sapiens_hsa051321.97510287
18Glycosaminoglycan degradation_Homo sapiens_hsa005311.91133473
19Other glycan degradation_Homo sapiens_hsa005111.89112010
20Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.81432301
21Measles_Homo sapiens_hsa051621.74627377
22RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.74387036
23Allograft rejection_Homo sapiens_hsa053301.72100220
24Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.66040193
25Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.64371190
26B cell receptor signaling pathway_Homo sapiens_hsa046621.63676049
27Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.61744055
28Hematopoietic cell lineage_Homo sapiens_hsa046401.61459108
29TNF signaling pathway_Homo sapiens_hsa046681.61275767
30Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.59075276
31Influenza A_Homo sapiens_hsa051641.52378353
32Chemokine signaling pathway_Homo sapiens_hsa040621.47671573
33Type I diabetes mellitus_Homo sapiens_hsa049401.47269713
34Toxoplasmosis_Homo sapiens_hsa051451.41010507
35Intestinal immune network for IgA production_Homo sapiens_hsa046721.39002576
36Bladder cancer_Homo sapiens_hsa052191.38094755
37African trypanosomiasis_Homo sapiens_hsa051431.35180135
38Shigellosis_Homo sapiens_hsa051311.34319664
39Leukocyte transendothelial migration_Homo sapiens_hsa046701.31404214
40Apoptosis_Homo sapiens_hsa042101.30298604
41Herpes simplex infection_Homo sapiens_hsa051681.27396245
42Antigen processing and presentation_Homo sapiens_hsa046121.25430879
43Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.20450017
44Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.18004941
45Hepatitis B_Homo sapiens_hsa051611.08168707
46Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.06713102
47Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.96062546
48Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.95449217
49Amoebiasis_Homo sapiens_hsa051460.92046505
50Jak-STAT signaling pathway_Homo sapiens_hsa046300.91738722
51Viral myocarditis_Homo sapiens_hsa054160.90162966
52AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.84505657
53Complement and coagulation cascades_Homo sapiens_hsa046100.84126950
54Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.82590246
55Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.81832965
56Platelet activation_Homo sapiens_hsa046110.81003562
57Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.79492936
58Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.74599514
59Neurotrophin signaling pathway_Homo sapiens_hsa047220.71770664
60Pancreatic cancer_Homo sapiens_hsa052120.71606138
61Hepatitis C_Homo sapiens_hsa051600.71394832
62SNARE interactions in vesicular transport_Homo sapiens_hsa041300.69531142
63Autoimmune thyroid disease_Homo sapiens_hsa053200.68457682
64Galactose metabolism_Homo sapiens_hsa000520.63936719
65T cell receptor signaling pathway_Homo sapiens_hsa046600.59175567
66Collecting duct acid secretion_Homo sapiens_hsa049660.58905419
67PPAR signaling pathway_Homo sapiens_hsa033200.57673023
68Sulfur metabolism_Homo sapiens_hsa009200.57463270
69Chronic myeloid leukemia_Homo sapiens_hsa052200.56903006
70Sphingolipid signaling pathway_Homo sapiens_hsa040710.55345951
71Epstein-Barr virus infection_Homo sapiens_hsa051690.51738411
72Acute myeloid leukemia_Homo sapiens_hsa052210.51623522
73Prion diseases_Homo sapiens_hsa050200.50755999
74Primary immunodeficiency_Homo sapiens_hsa053400.50691155
75Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.50179153
76Transcriptional misregulation in cancer_Homo sapiens_hsa052020.49622345
77DNA replication_Homo sapiens_hsa030300.46100120
78Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.45641446
79Pentose phosphate pathway_Homo sapiens_hsa000300.43032086
80Systemic lupus erythematosus_Homo sapiens_hsa053220.40408008
81Caffeine metabolism_Homo sapiens_hsa002320.39434975
82HIF-1 signaling pathway_Homo sapiens_hsa040660.37594002
83Regulation of actin cytoskeleton_Homo sapiens_hsa048100.37523316
84Fructose and mannose metabolism_Homo sapiens_hsa000510.37465739
85Viral carcinogenesis_Homo sapiens_hsa052030.36743767
86Sphingolipid metabolism_Homo sapiens_hsa006000.36056542
87Synaptic vesicle cycle_Homo sapiens_hsa047210.35546387
88Endocytosis_Homo sapiens_hsa041440.34397136
89VEGF signaling pathway_Homo sapiens_hsa043700.34077490
90Carbohydrate digestion and absorption_Homo sapiens_hsa049730.30976233
91Renin-angiotensin system_Homo sapiens_hsa046140.29796760
92GnRH signaling pathway_Homo sapiens_hsa049120.29563988
93Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.29164040
94Type II diabetes mellitus_Homo sapiens_hsa049300.26963376
95Renal cell carcinoma_Homo sapiens_hsa052110.25917490
96Primary bile acid biosynthesis_Homo sapiens_hsa001200.25497858
97Phospholipase D signaling pathway_Homo sapiens_hsa040720.25070459
98Pentose and glucuronate interconversions_Homo sapiens_hsa000400.24862371
99Mineral absorption_Homo sapiens_hsa049780.23413221
100Prolactin signaling pathway_Homo sapiens_hsa049170.22851229
101Small cell lung cancer_Homo sapiens_hsa052220.22408739
102Notch signaling pathway_Homo sapiens_hsa043300.22395006
103Arachidonic acid metabolism_Homo sapiens_hsa005900.21401717
104Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.21241415
105p53 signaling pathway_Homo sapiens_hsa041150.20715525
106Adipocytokine signaling pathway_Homo sapiens_hsa049200.20153635
107Vibrio cholerae infection_Homo sapiens_hsa051100.18108733
108Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.15787116
109HTLV-I infection_Homo sapiens_hsa051660.15286637
110Homologous recombination_Homo sapiens_hsa034400.14320574
111Insulin resistance_Homo sapiens_hsa049310.14306654
112MAPK signaling pathway_Homo sapiens_hsa040100.13745638
113Proteoglycans in cancer_Homo sapiens_hsa052050.13324070
114Histidine metabolism_Homo sapiens_hsa003400.12357736
115Starch and sucrose metabolism_Homo sapiens_hsa005000.11885393

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »