CLEC6A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a type II membrane receptor with an extracellular C-type lectin-like domain fold. The extracellular portion binds structures with a high mannose content and has been shown to recognize several pathogens, including C. elegans, S. cerevisiae, M. tuberculosis, C. neoformans, and house dust mite. When stimulated, the encoded protein initiates signalling through the CARD9-Bcl10-Malt1 pathway, leading to the induction of cytokines. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to peptidoglycan (GO:0032494)6.00961915
2positive regulation by symbiont of host defense response (GO:0052509)5.96842301
3modulation by symbiont of host defense response (GO:0052031)5.96842301
4modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.96842301
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.96842301
6positive regulation by organism of defense response of other organism involved in symbiotic interact5.96842301
7modulation by symbiont of host immune response (GO:0052553)5.96842301
8positive regulation of gamma-delta T cell activation (GO:0046645)5.56967498
9negative regulation of interleukin-12 production (GO:0032695)5.49894981
10neutrophil activation involved in immune response (GO:0002283)5.11589259
11positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)5.09550821
12macrophage activation involved in immune response (GO:0002281)5.05409432
13detection of molecule of bacterial origin (GO:0032490)5.02529134
14negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.68269885
15negative regulation of cell killing (GO:0031342)4.68269885
16detection of other organism (GO:0098543)4.52370603
17cellular extravasation (GO:0045123)4.44721330
18regulation of interferon-beta biosynthetic process (GO:0045357)4.40918402
19microglial cell activation (GO:0001774)4.33978585
20production of molecular mediator involved in inflammatory response (GO:0002532)4.33229594
21regulation of dendritic cell antigen processing and presentation (GO:0002604)4.20998521
22lipopolysaccharide-mediated signaling pathway (GO:0031663)4.15685271
23positive regulation of type 2 immune response (GO:0002830)4.14157414
24antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.13506642
25detection of external biotic stimulus (GO:0098581)4.12322777
26response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.08504286
27response to host immune response (GO:0052572)4.08504286
28immunoglobulin mediated immune response (GO:0016064)4.05244319
29detection of biotic stimulus (GO:0009595)3.97577192
30detection of bacterium (GO:0016045)3.93882726
31macrophage activation (GO:0042116)3.93750804
32regulation of gamma-delta T cell activation (GO:0046643)3.92022129
33regulation of tolerance induction (GO:0002643)3.91978429
34regulation of T cell tolerance induction (GO:0002664)3.85353268
35T-helper 1 type immune response (GO:0042088)3.84826456
36positive regulation of mast cell activation (GO:0033005)3.75799158
37response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.70995876
38response to host (GO:0075136)3.70995876
39response to host defenses (GO:0052200)3.70995876
40neutrophil mediated immunity (GO:0002446)3.69648938
41respiratory burst (GO:0045730)3.68560250
42regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.67723080
43positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.67097132
44positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.63619603
45positive regulation of tolerance induction (GO:0002645)3.63215191
46regulation of B cell receptor signaling pathway (GO:0050855)3.62303973
47leukocyte aggregation (GO:0070486)3.57668399
48positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.57604793
49neutrophil activation (GO:0042119)3.54522787
50myeloid cell activation involved in immune response (GO:0002275)3.54250305
51negative regulation of interleukin-17 production (GO:0032700)3.54178236
52granulocyte activation (GO:0036230)3.44835373
53negative regulation of T cell mediated immunity (GO:0002710)3.43897618
54regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.42283167
55positive regulation of cellular amide metabolic process (GO:0034250)3.41529622
56positive regulation of interleukin-1 beta secretion (GO:0050718)3.39545570
57regulation of mast cell activation (GO:0033003)3.38714343
58interferon-gamma-mediated signaling pathway (GO:0060333)3.38013927
59regulation of mast cell degranulation (GO:0043304)3.37528782
60antigen processing and presentation of endogenous antigen (GO:0019883)3.34448283
61defense response to protozoan (GO:0042832)3.33213514
62regulation of interleukin-12 production (GO:0032655)3.32901952
63response to muramyl dipeptide (GO:0032495)3.30718865
64positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.29672526
65positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.28454154
66myeloid leukocyte mediated immunity (GO:0002444)3.25067880
67positive regulation of antigen processing and presentation (GO:0002579)3.24536780
68positive regulation of mast cell activation involved in immune response (GO:0033008)3.24523761
69positive regulation of mast cell degranulation (GO:0043306)3.24523761
70regulation of interleukin-1 beta secretion (GO:0050706)3.22685256
71positive regulation of NF-kappaB import into nucleus (GO:0042346)3.21695620
72regulation of antigen processing and presentation (GO:0002577)3.20573676
73positive regulation of interferon-alpha production (GO:0032727)3.19813878
74regulation of mast cell activation involved in immune response (GO:0033006)3.19038209
75B cell mediated immunity (GO:0019724)3.17809239
76positive regulation of interleukin-1 secretion (GO:0050716)3.17243653
77antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.15082749
78positive regulation of toll-like receptor signaling pathway (GO:0034123)3.14977203
79regulation of interleukin-17 production (GO:0032660)3.13830837
80regulation of T-helper 1 cell differentiation (GO:0045625)3.13740467
81positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.12920475
82positive regulation of interleukin-10 production (GO:0032733)3.12246061
83cytokine secretion (GO:0050663)3.11726300
84regulation of interleukin-8 biosynthetic process (GO:0045414)3.10653387
85regulation of interferon-alpha production (GO:0032647)3.10070709
86negative regulation of lymphocyte mediated immunity (GO:0002707)3.09510107
87regulation of type 2 immune response (GO:0002828)3.06728565
88regulation of T-helper 2 cell differentiation (GO:0045628)3.06717870
89positive regulation of interleukin-17 production (GO:0032740)3.05592515
90regulation of myeloid leukocyte mediated immunity (GO:0002886)3.04213691
91regulation of vitamin D biosynthetic process (GO:0060556)3.01593356
92response to protozoan (GO:0001562)3.01365073
93positive regulation of T-helper cell differentiation (GO:0045624)3.01279826
94T cell migration (GO:0072678)2.99627396
95cellular response to type I interferon (GO:0071357)2.99182430
96type I interferon signaling pathway (GO:0060337)2.99182430
97positive regulation of interleukin-12 production (GO:0032735)2.95634481
98response to type I interferon (GO:0034340)2.95170045
99dendritic cell chemotaxis (GO:0002407)2.94278844
100positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.93710367

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.40806701
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.39605156
3IRF8_21731497_ChIP-ChIP_J774_Mouse5.32591431
4IRF8_27001747_Chip-Seq_BMDM_Mouse4.14690371
5SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.84779141
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.66295637
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.62539251
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.58114547
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.56874128
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.46957031
11MYB_21317192_ChIP-Seq_ERMYB_Mouse3.44197353
12NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.40267567
13Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.13666468
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.98529246
15RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.83611812
16SMAD_19615063_ChIP-ChIP_OVARY_Human2.69207336
17SPI1_23547873_ChIP-Seq_NB4_Human2.62479569
18STAT4_19710469_ChIP-ChIP_TH1__Mouse2.57571218
19SPI1_23127762_ChIP-Seq_K562_Human2.53217764
20NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.51710752
21EGR1_19374776_ChIP-ChIP_THP-1_Human2.49224404
22SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.43209810
23RUNX_20019798_ChIP-Seq_JUKART_Human2.42966788
24VDR_24787735_ChIP-Seq_THP-1_Human2.31818056
25SCL_19346495_ChIP-Seq_HPC-7_Human2.26293768
26VDR_24763502_ChIP-Seq_THP-1_Human2.20797298
27BRD4_27068464_Chip-Seq_AML-cells_Mouse2.18524342
28MYB_26560356_Chip-Seq_TH2_Human2.01371484
29RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.96319254
30NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.95346584
31FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.88103070
32CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.86602989
33RUNX1_22412390_ChIP-Seq_EML_Mouse1.84834215
34PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.82997901
35VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.82866780
36CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.77351697
37PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.76629083
38VDR_21846776_ChIP-Seq_THP-1_Human1.66696461
39PU_27001747_Chip-Seq_BMDM_Mouse1.64252191
40MAF_26560356_Chip-Seq_TH1_Human1.62383166
41GATA1_22025678_ChIP-Seq_K562_Human1.56448848
42MYB_26560356_Chip-Seq_TH1_Human1.52851378
43MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.51725856
44E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.49265859
45NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.49158696
46GATA3_27048872_Chip-Seq_THYMUS_Human1.47880262
47CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.42081960
48LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.41424579
49CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.37028759
50GATA3_26560356_Chip-Seq_TH2_Human1.36893300
51GATA1_19941827_ChIP-Seq_MEL_Mouse1.35960189
52LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.33182716
53CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.30312306
54PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.28857903
55UTX_26944678_Chip-Seq_JUKART_Human1.27097535
56TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.21935023
57GATA2_22383799_ChIP-Seq_G1ME_Mouse1.21056060
58SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20864983
59STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.16095744
60PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14475029
61FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.13293506
62SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12215687
63GATA2_21666600_ChIP-Seq_HMVEC_Human1.11326985
64SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.09973221
65TCF7_22412390_ChIP-Seq_EML_Mouse1.09577924
66GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07792276
67GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.07730936
68KDM2B_26808549_Chip-Seq_SUP-B15_Human1.03998915
69ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.99514072
70MAF_26560356_Chip-Seq_TH2_Human0.95070070
71MYC_22102868_ChIP-Seq_BL_Human0.93313107
72GATA1_22383799_ChIP-Seq_G1ME_Mouse0.93231175
73IKZF1_21737484_ChIP-ChIP_HCT116_Human0.91894140
74GATA1_19941826_ChIP-Seq_K562_Human0.91493486
75STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.87901895
76KDM2B_26808549_Chip-Seq_DND41_Human0.87582730
77EGR1_19032775_ChIP-ChIP_M12_Human0.86635133
78STAT6_21828071_ChIP-Seq_BEAS2B_Human0.86363849
79TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85473433
80GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85012491
81GATA2_19941826_ChIP-Seq_K562_Human0.83956111
82SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.83789323
83CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.83726618
84GATA1_19941827_ChIP-Seq_MEL86_Mouse0.80370716
85TFEB_21752829_ChIP-Seq_HELA_Human0.80002284
86SMRT_27268052_Chip-Seq_Bcells_Human0.79814805
87KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.77214049
88VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.77183804
89PU.1_20513432_ChIP-Seq_Bcells_Mouse0.74058582
90STAT1_20625510_ChIP-Seq_HELA_Human0.73705297
91KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.68909574
92RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.67040882
93SPI1_20517297_ChIP-Seq_HL60_Human0.64097693
94CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.61307034
95KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.61274592
96JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.59611051
97FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.58082190
98LXR_22158963_ChIP-Seq_LIVER_Mouse0.57577145
99BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.57477072
100KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.57126801

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.60106334
2MP0003303_peritoneal_inflammation4.33054366
3MP0001835_abnormal_antigen_presentation4.09671316
4MP0003436_decreased_susceptibility_to3.65994771
5MP0009785_altered_susceptibility_to3.46319691
6MP0006082_CNS_inflammation3.30505308
7MP0002148_abnormal_hypersensitivity_rea3.27515173
8MP0002419_abnormal_innate_immunity3.20064726
9MP0005671_abnormal_response_to2.93509953
10MP0005000_abnormal_immune_tolerance2.93108558
11MP0005025_abnormal_response_to2.81742714
12MP0000685_abnormal_immune_system2.80151774
13MP0001790_abnormal_immune_system2.72110414
14MP0005387_immune_system_phenotype2.72110414
15MP0001800_abnormal_humoral_immune2.67448829
16MP0002452_abnormal_antigen_presenting2.57993177
17MP0002723_abnormal_immune_serum2.50907116
18MP0009278_abnormal_bone_marrow2.24435658
19MP0001819_abnormal_immune_cell2.21363368
20MP0002420_abnormal_adaptive_immunity2.20981340
21MP0009764_decreased_sensitivity_to2.10354346
22MP0003191_abnormal_cellular_cholesterol2.05393844
23MP0001533_abnormal_skeleton_physiology2.04868316
24MP0008260_abnormal_autophagy2.02697521
25MP0003172_abnormal_lysosome_physiology2.01080985
26MP0003300_gastrointestinal_ulcer1.94290841
27MP0001845_abnormal_inflammatory_respons1.93894957
28MP0005464_abnormal_platelet_physiology1.90220527
29MP0004947_skin_inflammation1.87832161
30MP0003075_altered_response_to1.86558234
31MP0002405_respiratory_system_inflammati1.81355473
32MP0005058_abnormal_lysosome_morphology1.80326004
33MP0003828_pulmonary_edema1.79310426
34MP0010155_abnormal_intestine_physiology1.74071176
35MP0001545_abnormal_hematopoietic_system1.70896218
36MP0005397_hematopoietic_system_phenotyp1.70896218
37MP0004510_myositis1.68985951
38MP0008469_abnormal_protein_level1.65058133
39MP0000343_altered_response_to1.65034551
40MP0005451_abnormal_body_composition1.59648879
41MP0000716_abnormal_immune_system1.59522257
42MP0002998_abnormal_bone_remodeling1.57890658
43MP0005310_abnormal_salivary_gland1.56140758
44MP0003690_abnormal_glial_cell1.55113343
45MP0000858_altered_metastatic_potential1.51105112
46MP0005166_decreased_susceptibility_to1.48193284
47MP0003448_altered_tumor_morphology1.47915068
48MP0001853_heart_inflammation1.47196884
49MP0002398_abnormal_bone_marrow1.43332962
50MP0009333_abnormal_splenocyte_physiolog1.38443863
51MP0004883_abnormal_blood_vessel1.36793088
52MP0005167_abnormal_blood-brain_barrier1.34802833
53MP0003656_abnormal_erythrocyte_physiolo1.32357888
54MP0002006_tumorigenesis1.30050312
55MP0008004_abnormal_stomach_pH1.29924027
56MP0000604_amyloidosis1.27740202
57MP0005164_abnormal_response_to1.26188922
58MP0003806_abnormal_nucleotide_metabolis1.23253341
59MP0002429_abnormal_blood_cell1.22171504
60MP0000689_abnormal_spleen_morphology1.21184275
61MP0002722_abnormal_immune_system1.17107530
62MP0000465_gastrointestinal_hemorrhage1.11464529
63MP0000569_abnormal_digit_pigmentation1.11153272
64MP0002132_abnormal_respiratory_system1.09639540
65MP0002166_altered_tumor_susceptibility1.07845122
66MP0009840_abnormal_foam_cell1.06479380
67MP0002277_abnormal_respiratory_mucosa1.06465952
68MP0009763_increased_sensitivity_to1.03733853
69MP0002332_abnormal_exercise_endurance0.98024628
70MP0003763_abnormal_thymus_physiology0.96105499
71MP0009765_abnormal_xenobiotic_induced0.93792807
72MP0003866_abnormal_defecation0.93767469
73MP0003183_abnormal_peptide_metabolism0.93094455
74MP0006054_spinal_hemorrhage0.91342027
75MP0001851_eye_inflammation0.86550593
76MP0002254_reproductive_system_inflammat0.78124329
77MP0000920_abnormal_myelination0.77028592
78MP0002138_abnormal_hepatobiliary_system0.76873211
79MP0005390_skeleton_phenotype0.76259602
80MP0008874_decreased_physiological_sensi0.73775648
81MP0003195_calcinosis0.73176866
82MP0000703_abnormal_thymus_morphology0.71561198
83MP0003221_abnormal_cardiomyocyte_apopto0.70857906
84MP0003091_abnormal_cell_migration0.70099993
85MP0000249_abnormal_blood_vessel0.68318860
86MP0003453_abnormal_keratinocyte_physiol0.67761662
87MP0001663_abnormal_digestive_system0.65257781
88MP0003795_abnormal_bone_structure0.64509474
89MP0004808_abnormal_hematopoietic_stem0.63394974
90MP0000371_diluted_coat_color0.62044244
91MP0004484_altered_response_of0.59757346
92MP0003045_fibrosis0.59373615
93MP0002009_preneoplasia0.57024255
94MP0000015_abnormal_ear_pigmentation0.56997414
95MP0005319_abnormal_enzyme/_coenzyme0.52560666
96MP0005647_abnormal_sex_gland0.52412763
97MP0004381_abnormal_hair_follicle0.50920317
98MP0010352_gastrointestinal_tract_polyps0.50365158
99MP0005376_homeostasis/metabolism_phenot0.47324518
100MP0003329_amyloid_beta_deposits0.47100193

Predicted human phenotypes

RankGene SetZ-score
1Recurrent bacterial skin infections (HP:0005406)6.73071453
2Eczematoid dermatitis (HP:0000976)6.39217117
3Recurrent abscess formation (HP:0002722)6.30897366
4Abnormality of macrophages (HP:0004311)6.23699554
5Retrobulbar optic neuritis (HP:0100654)5.51064190
6Optic neuritis (HP:0100653)5.51064190
7Orchitis (HP:0100796)5.40878295
8Myositis (HP:0100614)5.19388871
9Stomatitis (HP:0010280)5.15569535
10Recurrent gram-negative bacterial infections (HP:0005420)5.10391229
11Gastrointestinal infarctions (HP:0005244)4.66689825
12Elevated erythrocyte sedimentation rate (HP:0003565)4.53167663
13Mediastinal lymphadenopathy (HP:0100721)4.30028352
14Recurrent skin infections (HP:0001581)4.22706258
15Recurrent fungal infections (HP:0002841)4.10352864
16Amyloidosis (HP:0011034)4.08962572
17Keratoconjunctivitis sicca (HP:0001097)3.94167120
18Keratoconjunctivitis (HP:0001096)3.64395154
19Recurrent cutaneous fungal infections (HP:0011370)3.64319381
20Chronic mucocutaneous candidiasis (HP:0002728)3.64319381
21Vasculitis (HP:0002633)3.61319489
22Abnormality of liposaccharide metabolism (HP:0010968)3.60716689
23Abnormality of glycosphingolipid metabolism (HP:0004343)3.60716689
24Abnormality of glycolipid metabolism (HP:0010969)3.60716689
25Hemoptysis (HP:0002105)3.59520230
26Obstructive lung disease (HP:0006536)3.54795138
27Chronic obstructive pulmonary disease (HP:0006510)3.54795138
28Urticaria (HP:0001025)3.45463139
29Gingivitis (HP:0000230)3.34658767
30Meningitis (HP:0001287)3.30593933
31Leukocytosis (HP:0001974)3.28683413
32Increased cerebral lipofuscin (HP:0011813)3.23158093
33Episodic fever (HP:0001954)3.19209473
34Pulmonary infiltrates (HP:0002113)3.18453667
35Recurrent viral infections (HP:0004429)3.16040055
36Spontaneous hematomas (HP:0007420)3.14616320
37Gangrene (HP:0100758)3.10579402
38Arterial thrombosis (HP:0004420)3.10441932
39Encephalitis (HP:0002383)3.08443867
40Chest pain (HP:0100749)3.01242777
41T lymphocytopenia (HP:0005403)2.97527420
42Abnormal delayed hypersensitivity skin test (HP:0002963)2.91272991
43Abnormality of T cell number (HP:0011839)2.90448158
44Gingival bleeding (HP:0000225)2.89274395
45Hematochezia (HP:0002573)2.86697874
46Anorexia (HP:0002039)2.83424984
47Amaurosis fugax (HP:0100576)2.82493241
48Loss of speech (HP:0002371)2.70683952
49Peritonitis (HP:0002586)2.67482803
50Vacuolated lymphocytes (HP:0001922)2.59148422
51Prolonged bleeding time (HP:0003010)2.54922604
52Increased serum ferritin (HP:0003281)2.53326509
53Myocardial infarction (HP:0001658)2.49162604
54Increased IgM level (HP:0003496)2.48004770
55Increased neuronal autofluorescent lipopigment (HP:0002074)2.47540882
56Autoimmune thrombocytopenia (HP:0001973)2.46081178
57Vertigo (HP:0002321)2.45071157
58Pulmonary embolism (HP:0002204)2.42330900
59Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.40686595
60Cellulitis (HP:0100658)2.37970439
61Epistaxis (HP:0000421)2.37745704
62Abnormality of the endocardium (HP:0004306)2.37093557
63Petechiae (HP:0000967)2.36935249
64Dysostosis multiplex (HP:0000943)2.36065919
65Malnutrition (HP:0004395)2.35775096
66Polyneuropathy (HP:0001271)2.35433768
67Osteomyelitis (HP:0002754)2.32679966
68Increased IgE level (HP:0003212)2.32086445
69Systemic lupus erythematosus (HP:0002725)2.29169814
70Premature loss of primary teeth (HP:0006323)2.25425367
71Eosinophilia (HP:0001880)2.22965713
72Purpura (HP:0000979)2.22417881
73Abnormality of the pleura (HP:0002103)2.21912898
74Colitis (HP:0002583)2.20291477
75Granulocytopenia (HP:0001913)2.17587170
76Chronic otitis media (HP:0000389)2.16149429
77Inflammation of the large intestine (HP:0002037)2.14974220
78Disinhibition (HP:0000734)2.13728214
79Abnormality of T cells (HP:0002843)2.06977802
80Abnormality of iron homeostasis (HP:0011031)2.06022274
81Cheilitis (HP:0100825)2.02536414
82Sepsis (HP:0100806)2.01337813
83Pustule (HP:0200039)2.00303366
84Fatigue (HP:0012378)1.99031286
85Glomerulopathy (HP:0100820)1.98863516
86Gastrointestinal inflammation (HP:0004386)1.97352411
87Abnormality of the peritoneum (HP:0002585)1.93361906
88Joint swelling (HP:0001386)1.89900082
89Hepatosplenomegaly (HP:0001433)1.89010519
90Abnormality of polysaccharide metabolism (HP:0011012)1.88770110
91Abnormality of glycosaminoglycan metabolism (HP:0004371)1.88770110
92Abnormality of mucopolysaccharide metabolism (HP:0011020)1.88770110
93Recurrent pneumonia (HP:0006532)1.88382102
94Hypergammaglobulinemia (HP:0010702)1.88342664
95Arthralgia (HP:0002829)1.88232518
96Keratitis (HP:0000491)1.87770641
97Acne (HP:0001061)1.83742593
98Thrombophlebitis (HP:0004418)1.82532026
99Mutism (HP:0002300)1.81580086
100Splenomegaly (HP:0001744)1.81417286

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK45.00195119
2TYK23.60812907
3BLK3.35279790
4CSK3.09087870
5IRAK32.99837844
6MAP3K142.89495674
7IRAK42.87809494
8FGR2.61883421
9MATK2.51457607
10JAK32.42849912
11MAP2K32.30897658
12MAP4K12.30232331
13PRPF4B2.22716131
14IKBKE2.10647256
15ZAP702.01545441
16GRK71.92714070
17JAK11.92162831
18MAP3K131.90957928
19TXK1.89609678
20FES1.78595877
21BMPR21.74916630
22MAP3K31.58207944
23TBK11.53524453
24SYK1.51545184
25JAK21.50902886
26IKBKB1.45471837
27TAOK31.44769647
28IRAK11.44516120
29KIT1.40867522
30LYN1.39103461
31IRAK21.37189196
32HCK1.36524278
33ERN11.31537968
34TAOK11.29422243
35EPHB11.27200637
36BTK1.23998878
37MAP3K61.23138001
38PIK3CG1.22777778
39MAP3K11.21576802
40CSF1R1.16854731
41TNK21.13844658
42GRK61.10618557
43KSR21.10151927
44YES11.10145592
45FGFR31.09492818
46FGFR41.09250753
47LCK0.95405751
48TAOK20.95247441
49MAP3K50.94688335
50TGFBR20.92710685
51CDC42BPA0.89276335
52SIK30.89190105
53STK100.87282316
54MAP3K110.85676068
55MARK30.82638374
56DDR20.80942788
57TEC0.77936625
58PDK10.74245046
59MOS0.73883835
60CAMKK20.72726734
61PDPK10.71431859
62DAPK20.68850509
63CHUK0.65842465
64MARK20.64861749
65ITK0.63996355
66PDK20.62090093
67EPHA30.61449611
68MAP3K20.59805465
69ADRBK20.58645560
70MAPK70.57418509
71FYN0.52732791
72ARAF0.51814487
73MAP2K40.51498345
74SGK30.49766572
75LRRK20.48979030
76KSR10.48236501
77NLK0.43065255
78PIM10.42454971
79ACVR1B0.41433567
80ABL10.38383261
81CAMK1D0.37344908
82RAF10.36950469
83SGK20.35801164
84PTK2B0.35635202
85STK240.35464922
86EGFR0.34853974
87PDGFRB0.34639087
88MAPK120.32196039
89CDK190.31034238
90PRKCQ0.30860736
91RPS6KC10.29748245
92RPS6KL10.29748245
93CAMK40.28937772
94PRKCD0.28715414
95PRKD20.26105730
96NEK90.24250521
97RPS6KA60.23999708
98TESK20.23913571
99TYRO30.23599495
100INSR0.22672895

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.34461351
2Osteoclast differentiation_Homo sapiens_hsa043803.02318445
3Staphylococcus aureus infection_Homo sapiens_hsa051502.86543010
4Toll-like receptor signaling pathway_Homo sapiens_hsa046202.80678363
5Graft-versus-host disease_Homo sapiens_hsa053322.64953712
6NOD-like receptor signaling pathway_Homo sapiens_hsa046212.54478537
7Tuberculosis_Homo sapiens_hsa051522.50459426
8Allograft rejection_Homo sapiens_hsa053302.47249998
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.42260980
10Legionellosis_Homo sapiens_hsa051342.40444247
11Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.29398990
12Type I diabetes mellitus_Homo sapiens_hsa049402.08890903
13Rheumatoid arthritis_Homo sapiens_hsa053232.05333974
14NF-kappa B signaling pathway_Homo sapiens_hsa040642.01738010
15Autoimmune thyroid disease_Homo sapiens_hsa053202.00248452
16Malaria_Homo sapiens_hsa051441.97714724
17Pertussis_Homo sapiens_hsa051331.90440028
18Influenza A_Homo sapiens_hsa051641.80668524
19Intestinal immune network for IgA production_Homo sapiens_hsa046721.79251905
20B cell receptor signaling pathway_Homo sapiens_hsa046621.77452201
21Asthma_Homo sapiens_hsa053101.76702220
22Measles_Homo sapiens_hsa051621.71594465
23African trypanosomiasis_Homo sapiens_hsa051431.71227800
24TNF signaling pathway_Homo sapiens_hsa046681.70342590
25Chemokine signaling pathway_Homo sapiens_hsa040621.69073014
26Toxoplasmosis_Homo sapiens_hsa051451.67619912
27Hematopoietic cell lineage_Homo sapiens_hsa046401.67434344
28RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.65184630
29Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.58393289
30Other glycan degradation_Homo sapiens_hsa005111.54282613
31Phagosome_Homo sapiens_hsa041451.53699883
32Antigen processing and presentation_Homo sapiens_hsa046121.48827119
33Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.48591219
34Lysosome_Homo sapiens_hsa041421.46104030
35Salmonella infection_Homo sapiens_hsa051321.39908668
36Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.38879572
37Herpes simplex infection_Homo sapiens_hsa051681.35618934
38Viral myocarditis_Homo sapiens_hsa054161.33721390
39Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.31667059
40Jak-STAT signaling pathway_Homo sapiens_hsa046301.25418376
41Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.20817799
42Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.16558938
43Hepatitis B_Homo sapiens_hsa051611.13142937
44Primary immunodeficiency_Homo sapiens_hsa053401.12984541
45Hepatitis C_Homo sapiens_hsa051601.09688950
46Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.09063499
47T cell receptor signaling pathway_Homo sapiens_hsa046601.05991622
48Acute myeloid leukemia_Homo sapiens_hsa052211.04948462
49Shigellosis_Homo sapiens_hsa051311.00581748
50Glycosaminoglycan degradation_Homo sapiens_hsa005310.90875636
51AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.88320295
52Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.88175579
53Apoptosis_Homo sapiens_hsa042100.85160473
54Amoebiasis_Homo sapiens_hsa051460.84432651
55Prolactin signaling pathway_Homo sapiens_hsa049170.82433091
56Platelet activation_Homo sapiens_hsa046110.75803168
57Leukocyte transendothelial migration_Homo sapiens_hsa046700.72645472
58Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.70635525
59Pancreatic cancer_Homo sapiens_hsa052120.69914557
60SNARE interactions in vesicular transport_Homo sapiens_hsa041300.69209780
61Adipocytokine signaling pathway_Homo sapiens_hsa049200.68207188
62Dorso-ventral axis formation_Homo sapiens_hsa043200.67333137
63Neurotrophin signaling pathway_Homo sapiens_hsa047220.67041218
64HIF-1 signaling pathway_Homo sapiens_hsa040660.60922184
65Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.59210990
66Renal cell carcinoma_Homo sapiens_hsa052110.58642551
67Sphingolipid signaling pathway_Homo sapiens_hsa040710.58460383
68Non-small cell lung cancer_Homo sapiens_hsa052230.57886769
69Epstein-Barr virus infection_Homo sapiens_hsa051690.54756840
70VEGF signaling pathway_Homo sapiens_hsa043700.53608602
71Type II diabetes mellitus_Homo sapiens_hsa049300.52518959
72GnRH signaling pathway_Homo sapiens_hsa049120.50342005
73Collecting duct acid secretion_Homo sapiens_hsa049660.49457604
74Chronic myeloid leukemia_Homo sapiens_hsa052200.47510622
75Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.47256277
76Bladder cancer_Homo sapiens_hsa052190.45777286
77Mineral absorption_Homo sapiens_hsa049780.45506442
78Fatty acid biosynthesis_Homo sapiens_hsa000610.44865850
79Carbohydrate digestion and absorption_Homo sapiens_hsa049730.43863308
80Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.43801107
81Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.42259762
82Endocytosis_Homo sapiens_hsa041440.39897970
83Phospholipase D signaling pathway_Homo sapiens_hsa040720.38353529
84Prion diseases_Homo sapiens_hsa050200.37872058
85Notch signaling pathway_Homo sapiens_hsa043300.37799830
86FoxO signaling pathway_Homo sapiens_hsa040680.36843795
87Transcriptional misregulation in cancer_Homo sapiens_hsa052020.36759840
88Complement and coagulation cascades_Homo sapiens_hsa046100.34906333
89Viral carcinogenesis_Homo sapiens_hsa052030.34185674
90Galactose metabolism_Homo sapiens_hsa000520.32347468
91MAPK signaling pathway_Homo sapiens_hsa040100.30493717
92HTLV-I infection_Homo sapiens_hsa051660.27030167
93Insulin resistance_Homo sapiens_hsa049310.26723052
94Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.25587648
95Endometrial cancer_Homo sapiens_hsa052130.24642214
96Choline metabolism in cancer_Homo sapiens_hsa052310.23618760
97Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.21242597
98Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.19863985
99PPAR signaling pathway_Homo sapiens_hsa033200.19338239
100ErbB signaling pathway_Homo sapiens_hsa040120.18232374

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