CLEC7A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif. It functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G7.49229647
2neutrophil activation involved in immune response (GO:0002283)6.88968580
3positive regulation by symbiont of host defense response (GO:0052509)6.27058563
4modulation by symbiont of host defense response (GO:0052031)6.27058563
5modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.27058563
6modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.27058563
7positive regulation by organism of defense response of other organism involved in symbiotic interact6.27058563
8modulation by symbiont of host immune response (GO:0052553)6.27058563
9negative regulation of cell killing (GO:0031342)5.83612450
10negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.83612450
11respiratory burst (GO:0045730)5.28972494
12detection of other organism (GO:0098543)5.24557622
13macrophage activation involved in immune response (GO:0002281)5.08255019
14detection of external biotic stimulus (GO:0098581)4.99869152
15response to peptidoglycan (GO:0032494)4.86508849
16hydrogen peroxide biosynthetic process (GO:0050665)4.82676604
17negative regulation of interleukin-12 production (GO:0032695)4.80595472
18granulocyte activation (GO:0036230)4.78469748
19detection of bacterium (GO:0016045)4.75598001
20antigen processing and presentation of endogenous antigen (GO:0019883)4.73448640
21immunoglobulin mediated immune response (GO:0016064)4.68808201
22neutrophil activation (GO:0042119)4.60045606
23antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.56701226
24superoxide anion generation (GO:0042554)4.55752758
25positive regulation of interferon-alpha production (GO:0032727)4.52481796
26detection of biotic stimulus (GO:0009595)4.48455043
27production of molecular mediator involved in inflammatory response (GO:0002532)4.47789061
28regulation of interferon-beta biosynthetic process (GO:0045357)4.43929783
29positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)4.41263809
30positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.36328312
31reactive oxygen species biosynthetic process (GO:1903409)4.32459997
32regulation of interferon-alpha production (GO:0032647)4.25200120
33response to host immune response (GO:0052572)4.20286798
34response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.20286798
35regulation of gamma-delta T cell activation (GO:0046643)4.19034155
36positive regulation of monocyte chemotaxis (GO:0090026)4.17952052
37positive regulation of mast cell activation (GO:0033005)4.08373166
38antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.07081701
39positive regulation of mast cell activation involved in immune response (GO:0033008)4.05176783
40positive regulation of mast cell degranulation (GO:0043306)4.05176783
41lipopolysaccharide-mediated signaling pathway (GO:0031663)4.02642519
42myeloid cell activation involved in immune response (GO:0002275)4.02325189
43negative regulation of lymphocyte mediated immunity (GO:0002707)3.97459280
44positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610813.89237990
45positive regulation of cellular amide metabolic process (GO:0034250)3.83822536
46microglial cell activation (GO:0001774)3.77841918
47positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.77658723
48regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.75847242
49regulation of mast cell degranulation (GO:0043304)3.72789564
50eosinophil chemotaxis (GO:0048245)3.72715650
51leukocyte migration involved in inflammatory response (GO:0002523)3.72329870
52natural killer cell mediated immunity (GO:0002228)3.70952008
53natural killer cell mediated cytotoxicity (GO:0042267)3.70952008
54response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.67492855
55response to host (GO:0075136)3.67492855
56response to host defenses (GO:0052200)3.67492855
57cellular response to zinc ion (GO:0071294)3.66990321
58regulation of mononuclear cell migration (GO:0071675)3.63165986
59negative regulation of T cell mediated immunity (GO:0002710)3.61712018
60positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.60717947
61macrophage activation (GO:0042116)3.60319286
62positive regulation of chemokine biosynthetic process (GO:0045080)3.58290623
63myeloid leukocyte mediated immunity (GO:0002444)3.55705150
64antigen processing and presentation via MHC class Ib (GO:0002475)3.55630790
65regulation of gamma-delta T cell differentiation (GO:0045586)3.53849919
66regulation of mast cell activation (GO:0033003)3.52287240
67phagosome maturation (GO:0090382)3.50069152
68regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.48829560
69negative regulation of leukocyte mediated immunity (GO:0002704)3.48006628
70regulation of monocyte chemotaxis (GO:0090025)3.44876963
71regulation of mast cell activation involved in immune response (GO:0033006)3.44777305
72myeloid dendritic cell differentiation (GO:0043011)3.43496009
73response to interleukin-15 (GO:0070672)3.42861026
74detection of molecule of bacterial origin (GO:0032490)3.42786770
75eosinophil migration (GO:0072677)3.40794556
76response to muramyl dipeptide (GO:0032495)3.40279222
77positive regulation of macrophage cytokine production (GO:0060907)3.38904989
78positive regulation of interferon-beta production (GO:0032728)3.38877216
79regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.37487178
80B cell mediated immunity (GO:0019724)3.36902455
81negative regulation of interleukin-17 production (GO:0032700)3.36271430
82leukocyte mediated cytotoxicity (GO:0001909)3.35356254
83regulation of tolerance induction (GO:0002643)3.35053993
84positive regulation of leukocyte degranulation (GO:0043302)3.32070231
85positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.30057354
86regulation of T cell tolerance induction (GO:0002664)3.29296622
87positive regulation of antigen processing and presentation (GO:0002579)3.28867332
88wound healing, spreading of epidermal cells (GO:0035313)3.24128549
89myeloid dendritic cell activation (GO:0001773)3.23128964
90cellular extravasation (GO:0045123)3.22838540
91regulation of cholesterol storage (GO:0010885)3.21280829
92negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.19841646
93cellular response to interleukin-15 (GO:0071350)3.16837831
94B cell receptor signaling pathway (GO:0050853)3.16798985
95regulation of B cell receptor signaling pathway (GO:0050855)3.14852949
96positive regulation of toll-like receptor signaling pathway (GO:0034123)3.14757065
97regulation of leukocyte degranulation (GO:0043300)3.14164810
98T-helper 1 type immune response (GO:0042088)3.12921226
99positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.12717919
100regulation of myeloid leukocyte mediated immunity (GO:0002886)3.12496182
101myeloid leukocyte activation (GO:0002274)3.11322522
102leukocyte aggregation (GO:0070486)3.09886628
103regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.09183069
104regulation of T-helper 2 cell differentiation (GO:0045628)3.08943893
105monocyte chemotaxis (GO:0002548)3.08938445
106leukocyte degranulation (GO:0043299)3.07534471
107negative regulation of mast cell activation (GO:0033004)3.05986694
108regulation of interleukin-8 biosynthetic process (GO:0045414)3.03975117
109positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.03665300
110dendritic cell migration (GO:0036336)3.03316433
111dendritic cell differentiation (GO:0097028)2.99807549
112regulation of chemokine biosynthetic process (GO:0045073)2.99569780
113positive regulation of interleukin-12 production (GO:0032735)2.99511646
114activated T cell proliferation (GO:0050798)2.99483746
115neutrophil chemotaxis (GO:0030593)2.98918010
116positive thymic T cell selection (GO:0045059)2.94389217
117positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.93775393
118regulation of B cell differentiation (GO:0045577)2.92788446
119positive regulation of interleukin-1 beta secretion (GO:0050718)2.91768367
120lymphocyte chemotaxis (GO:0048247)2.91619039
121negative regulation of myeloid cell apoptotic process (GO:0033033)2.91613915
122negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.91313223
123negative thymic T cell selection (GO:0045060)2.90653332
124neutrophil migration (GO:1990266)2.90616877
125germinal center formation (GO:0002467)2.88996640
126positive regulation of B cell differentiation (GO:0045579)2.88830557
127cellular response to exogenous dsRNA (GO:0071360)2.88080052
128regulation of interleukin-12 biosynthetic process (GO:0045075)2.83562597
129interferon-gamma-mediated signaling pathway (GO:0060333)2.83076253
130positive regulation of type 2 immune response (GO:0002830)2.82656342
131neutrophil mediated immunity (GO:0002446)2.82400719
132regulation of T-helper 1 cell differentiation (GO:0045625)2.82365509
133type I interferon signaling pathway (GO:0060337)2.80067527
134cellular response to type I interferon (GO:0071357)2.80067527
135regulation of dendritic cell antigen processing and presentation (GO:0002604)2.79730089
136lymphocyte mediated immunity (GO:0002449)2.79229755
137response to type I interferon (GO:0034340)2.78542181
138positive regulation of gamma-delta T cell activation (GO:0046645)2.78290859
139positive regulation of natural killer cell differentiation (GO:0032825)2.77423437
140regulation of antigen processing and presentation (GO:0002577)2.76749708

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human8.08376743
2IRF8_21731497_ChIP-ChIP_J774_Mouse7.39679356
3* IRF8_22096565_ChIP-ChIP_GC-B_Human6.28123339
4IRF8_27001747_Chip-Seq_BMDM_Mouse4.70624317
5Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse4.48620063
6* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse4.28664808
7NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.93101804
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.76462741
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.39615642
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.22268728
11* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.21224815
12MYB_21317192_ChIP-Seq_ERMYB_Mouse3.17599748
13RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.91456834
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.82697008
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.66571287
16EGR1_19374776_ChIP-ChIP_THP-1_Human2.62656730
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.58101763
18STAT4_19710469_ChIP-ChIP_TH1__Mouse2.38835740
19NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.23388572
20PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse2.14934089
21* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.10034274
22SPI1_23547873_ChIP-Seq_NB4_Human2.06146261
23CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.04445400
24STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.91736861
25PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.90835073
26VDR_24787735_ChIP-Seq_THP-1_Human1.85889162
27CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.85121188
28CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.82974185
29STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.81848187
30PU_27001747_Chip-Seq_BMDM_Mouse1.78501120
31NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.75586619
32RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.61649084
33RUNX_20019798_ChIP-Seq_JUKART_Human1.58680242
34SPI1_23127762_ChIP-Seq_K562_Human1.56473756
35RUNX1_22412390_ChIP-Seq_EML_Mouse1.55768576
36VDR_24763502_ChIP-Seq_THP-1_Human1.55205028
37MYB_26560356_Chip-Seq_TH2_Human1.53288591
38CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.52998731
39THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.50687377
40VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.49801546
41CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.42544489
42PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.41395090
43ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.40662280
44FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.35288857
45MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.29347855
46NRF2_20460467_ChIP-Seq_MEFs_Mouse1.28302312
47NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.28302312
48BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.27905575
49SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.26872668
50TCF7_22412390_ChIP-Seq_EML_Mouse1.25697121
51MAF_26560356_Chip-Seq_TH2_Human1.23235189
52GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.21200831
53SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.21057344
54LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.20441083
55GATA2_21666600_ChIP-Seq_HMVEC_Human1.19896433
56NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.19096498
57KDM2B_26808549_Chip-Seq_SUP-B15_Human1.18693059
58CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.17570999
59MAF_26560356_Chip-Seq_TH1_Human1.16866964
60SCL_19346495_ChIP-Seq_HPC-7_Human1.15861726
61GATA3_26560356_Chip-Seq_TH2_Human1.15124883
62TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.14618518
63PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12821840
64VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.10828881
65CDX2_19796622_ChIP-Seq_MESCs_Mouse1.07660659
66GATA3_27048872_Chip-Seq_THYMUS_Human1.07028370
67MYB_26560356_Chip-Seq_TH1_Human1.06876069
68FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.05799186
69MYC_22102868_ChIP-Seq_BL_Human1.03519035
70RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.03182746
71TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.02617349
72SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.01089619
73KDM2B_26808549_Chip-Seq_DND41_Human1.00477020
74STAT6_21828071_ChIP-Seq_BEAS2B_Human1.00296952
75LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.98012383
76ELF1_17652178_ChIP-ChIP_JURKAT_Human0.97217665
77GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.96891716
78GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96602960
79IKZF1_21737484_ChIP-ChIP_HCT116_Human0.95905520
80KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.94369745
81GATA2_22383799_ChIP-Seq_G1ME_Mouse0.94344335
82GATA1_19941826_ChIP-Seq_K562_Human0.93273254
83TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91179612
84GATA1_22383799_ChIP-Seq_G1ME_Mouse0.90519609
85SOX2_20726797_ChIP-Seq_SW620_Human0.90148954
86E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.89860518
87SMAD_19615063_ChIP-ChIP_OVARY_Human0.89589953
88GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87941935
89CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.87561390
90SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.87223654
91GATA1_19941827_ChIP-Seq_MEL86_Mouse0.79735687
92* CJUN_26792858_Chip-Seq_BT549_Human0.79221067
93FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.78918511
94KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.78755487
95VDR_21846776_ChIP-Seq_THP-1_Human0.78356501
96PU.1_20513432_ChIP-Seq_Bcells_Mouse0.75969221
97TFEB_21752829_ChIP-Seq_HELA_Human0.75683982
98JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.75178292
99SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74804382
100JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.72796921
101* EGR1_23403033_ChIP-Seq_LIVER_Mouse0.70925010
102RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.70852274
103RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.70594887
104UTX_26944678_Chip-Seq_JUKART_Human0.70449375
105SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.70115224
106EGR1_19032775_ChIP-ChIP_M12_Human0.69920429
107CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.69648612
108SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.69161141
109SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.69161141
110BCL6_27268052_Chip-Seq_Bcells_Human0.68940499
111ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.67910908
112* SMRT_27268052_Chip-Seq_Bcells_Human0.66987005
113KDM2B_26808549_Chip-Seq_JURKAT_Human0.65779096
114TRIM28_21343339_ChIP-Seq_HEK293_Human0.64048422
115RARG_19884340_ChIP-ChIP_MEFs_Mouse0.63826411
116* RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.63669201
117SPI1_20517297_ChIP-Seq_HL60_Human0.63018307
118GATA3_26560356_Chip-Seq_TH1_Human0.62966199
119SALL4_18804426_ChIP-ChIP_XEN_Mouse0.62916819
120* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.62267394
121GATA2_19941826_ChIP-Seq_K562_Human0.62132175
122CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.61902656
123GATA1_19941827_ChIP-Seq_MEL_Mouse0.61830428
124FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.60427266
125LXR_22158963_ChIP-Seq_LIVER_Mouse0.60285242
126GATA1_22025678_ChIP-Seq_K562_Human0.60127319
127KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.58766346
128TP63_17297297_ChIP-ChIP_HaCaT_Human0.56900033

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation5.00049274
2MP0003436_decreased_susceptibility_to4.36445432
3MP0003303_peritoneal_inflammation4.02193464
4MP0002148_abnormal_hypersensitivity_rea3.82402731
5MP0009785_altered_susceptibility_to3.65705292
6MP0006082_CNS_inflammation3.63873035
7* MP0002419_abnormal_innate_immunity3.43224739
8MP0005000_abnormal_immune_tolerance3.31464698
9MP0003724_increased_susceptibility_to3.11551722
10MP0005058_abnormal_lysosome_morphology3.06224110
11* MP0005025_abnormal_response_to2.99372223
12MP0004510_myositis2.83966207
13* MP0002452_abnormal_antigen_presenting2.65350603
14MP0005671_abnormal_response_to2.50064198
15MP0005387_immune_system_phenotype2.44697235
16MP0001790_abnormal_immune_system2.44697235
17* MP0002723_abnormal_immune_serum2.41904563
18MP0001800_abnormal_humoral_immune2.27187363
19MP0001853_heart_inflammation2.24362089
20* MP0001819_abnormal_immune_cell2.18243412
21MP0000685_abnormal_immune_system2.16771839
22MP0005464_abnormal_platelet_physiology2.16257948
23MP0001533_abnormal_skeleton_physiology2.14759412
24* MP0002420_abnormal_adaptive_immunity2.13328615
25MP0009764_decreased_sensitivity_to2.06736674
26MP0002405_respiratory_system_inflammati2.05857207
27MP0003172_abnormal_lysosome_physiology2.03363393
28MP0003075_altered_response_to1.97915230
29MP0003448_altered_tumor_morphology1.97186287
30MP0003191_abnormal_cellular_cholesterol1.93564705
31MP0000343_altered_response_to1.92192873
32* MP0001845_abnormal_inflammatory_respons1.84315370
33MP0005310_abnormal_salivary_gland1.76445510
34MP0005166_decreased_susceptibility_to1.75200211
35MP0003690_abnormal_glial_cell1.73288136
36MP0002998_abnormal_bone_remodeling1.69496001
37MP0008469_abnormal_protein_level1.67737796
38MP0003763_abnormal_thymus_physiology1.65377813
39MP0002132_abnormal_respiratory_system1.60446751
40MP0004947_skin_inflammation1.59975588
41MP0004782_abnormal_surfactant_physiolog1.57706835
42MP0010155_abnormal_intestine_physiology1.54738223
43MP0009840_abnormal_foam_cell1.48716338
44MP0009333_abnormal_splenocyte_physiolog1.46348405
45MP0000716_abnormal_immune_system1.46153992
46MP0000569_abnormal_digit_pigmentation1.42521237
47MP0002006_tumorigenesis1.42249964
48MP0000858_altered_metastatic_potential1.41859707
49MP0000604_amyloidosis1.36844508
50MP0004381_abnormal_hair_follicle1.36636405
51MP0003186_abnormal_redox_activity1.27406053
52MP0005167_abnormal_blood-brain_barrier1.26637434
53MP0003828_pulmonary_edema1.24897902
54MP0002398_abnormal_bone_marrow1.23776652
55MP0001851_eye_inflammation1.17307522
56MP0002396_abnormal_hematopoietic_system1.15478078
57MP0005164_abnormal_response_to1.14954947
58MP0002429_abnormal_blood_cell1.13348511
59MP0005174_abnormal_tail_pigmentation1.12661970
60MP0009278_abnormal_bone_marrow1.12239328
61MP0000703_abnormal_thymus_morphology1.09892477
62MP0008260_abnormal_autophagy1.09071961
63MP0002254_reproductive_system_inflammat1.07734617
64MP0001545_abnormal_hematopoietic_system1.06080152
65MP0005397_hematopoietic_system_phenotyp1.06080152
66MP0002138_abnormal_hepatobiliary_system1.05403659
67MP0010386_abnormal_urinary_bladder1.03106502
68MP0000689_abnormal_spleen_morphology1.03080886
69MP0005390_skeleton_phenotype1.01186918
70MP0003300_gastrointestinal_ulcer0.96526670
71MP0002722_abnormal_immune_system0.94903891
72MP0008004_abnormal_stomach_pH0.94259738
73MP0002277_abnormal_respiratory_mucosa0.93049564
74MP0005257_abnormal_intraocular_pressure0.91565711
75MP0002090_abnormal_vision0.90656402
76MP0000920_abnormal_myelination0.89760586
77MP0003183_abnormal_peptide_metabolism0.88548747
78MP0002933_joint_inflammation0.87590172
79* MP0009763_increased_sensitivity_to0.85610897
80MP0004883_abnormal_blood_vessel0.83759592
81MP0005075_abnormal_melanosome_morpholog0.82200285
82MP0002166_altered_tumor_susceptibility0.80951196
83MP0001986_abnormal_taste_sensitivity0.80371379
84MP0003566_abnormal_cell_adhesion0.79991099
85MP0005076_abnormal_cell_differentiation0.79694786
86MP0000249_abnormal_blood_vessel0.78906326
87MP0003806_abnormal_nucleotide_metabolis0.78789045
88MP0003656_abnormal_erythrocyte_physiolo0.78716430
89MP0010307_abnormal_tumor_latency0.77044253
90MP0003453_abnormal_keratinocyte_physiol0.75206498
91MP0003795_abnormal_bone_structure0.75125483
92MP0005451_abnormal_body_composition0.74903002
93MP0000371_diluted_coat_color0.72905245
94MP0003045_fibrosis0.71304875
95MP0000015_abnormal_ear_pigmentation0.70925756
96MP0010352_gastrointestinal_tract_polyps0.70901752
97MP0002136_abnormal_kidney_physiology0.68495480
98MP0009765_abnormal_xenobiotic_induced0.65946393
99MP0004484_altered_response_of0.64538811
100MP0004130_abnormal_muscle_cell0.63361474
101MP0003705_abnormal_hypodermis_morpholog0.63215287
102MP0006054_spinal_hemorrhage0.62473956
103MP0004808_abnormal_hematopoietic_stem0.62017349
104* MP0001663_abnormal_digestive_system0.60774334
105MP0008874_decreased_physiological_sensi0.59372227
106MP0003221_abnormal_cardiomyocyte_apopto0.57827596
107MP0003329_amyloid_beta_deposits0.56047226
108MP0002332_abnormal_exercise_endurance0.55591450
109MP0003787_abnormal_imprinting0.54619325
110MP0005388_respiratory_system_phenotype0.54229482
111MP0002133_abnormal_respiratory_system0.54229482
112MP0002295_abnormal_pulmonary_circulatio0.53362612
113MP0000465_gastrointestinal_hemorrhage0.51819859
114MP0005376_homeostasis/metabolism_phenot0.51637622
115MP0000372_irregular_coat_pigmentation0.51314731
116MP0008873_increased_physiological_sensi0.50423468
117MP0003866_abnormal_defecation0.47762886
118MP0002693_abnormal_pancreas_physiology0.47431994
119MP0003279_aneurysm0.47059762
120MP0000767_abnormal_smooth_muscle0.46883140
121MP0001958_emphysema0.46816930
122MP0005319_abnormal_enzyme/_coenzyme0.46751523
123MP0000490_abnormal_crypts_of0.46008685

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)8.62126609
2Recurrent abscess formation (HP:0002722)8.14542008
3Recurrent gram-negative bacterial infections (HP:0005420)7.95846280
4Recurrent bacterial skin infections (HP:0005406)7.53773451
5Abnormality of macrophages (HP:0004311)6.06318875
6Mediastinal lymphadenopathy (HP:0100721)5.21075103
7Vacuolated lymphocytes (HP:0001922)5.15400319
8Gingivitis (HP:0000230)4.87137672
9Increased cerebral lipofuscin (HP:0011813)4.85762238
10Chronic obstructive pulmonary disease (HP:0006510)4.45414764
11Obstructive lung disease (HP:0006536)4.45414764
12Increased neuronal autofluorescent lipopigment (HP:0002074)4.41433682
13Axonal loss (HP:0003447)4.35170519
14Disinhibition (HP:0000734)4.21391100
15* Recurrent skin infections (HP:0001581)4.00520030
16Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.95426462
17Orchitis (HP:0100796)3.93950103
18Autoimmune thrombocytopenia (HP:0001973)3.91103861
19Stomatitis (HP:0010280)3.88325099
20Myositis (HP:0100614)3.83335068
21Systemic lupus erythematosus (HP:0002725)3.79445658
22Abnormality of liposaccharide metabolism (HP:0010968)3.77338919
23Abnormality of glycosphingolipid metabolism (HP:0004343)3.77338919
24Abnormality of glycolipid metabolism (HP:0010969)3.77338919
25Optic neuritis (HP:0100653)3.72471974
26Retrobulbar optic neuritis (HP:0100654)3.72471974
27Encephalitis (HP:0002383)3.72309199
28Abnormal delayed hypersensitivity skin test (HP:0002963)3.68733826
29Elevated erythrocyte sedimentation rate (HP:0003565)3.67628994
30* Recurrent fungal infections (HP:0002841)3.48064752
31T lymphocytopenia (HP:0005403)3.42721613
32Interstitial pulmonary disease (HP:0006530)3.37015876
33Cellulitis (HP:0100658)3.35894106
34Basal ganglia calcification (HP:0002135)3.33960989
35Chest pain (HP:0100749)3.31796202
36Agnosia (HP:0010524)3.26162435
37* Hemoptysis (HP:0002105)3.18189939
38Prostate neoplasm (HP:0100787)3.15104785
39Vasculitis (HP:0002633)3.11687868
40Amyloidosis (HP:0011034)3.07183669
41Periodontitis (HP:0000704)3.06481127
42Urticaria (HP:0001025)3.04512878
43Episodic fever (HP:0001954)3.01297465
44Dysostosis multiplex (HP:0000943)2.99505439
45Peritonitis (HP:0002586)2.98631400
46Myocardial infarction (HP:0001658)2.92898890
47* Recurrent cutaneous fungal infections (HP:0011370)2.90912609
48* Chronic mucocutaneous candidiasis (HP:0002728)2.90912609
49Pulmonary embolism (HP:0002204)2.88156334
50Prolonged bleeding time (HP:0003010)2.88011738
51Recurrent pneumonia (HP:0006532)2.84337274
52Increased IgE level (HP:0003212)2.81215843
53Hepatosplenomegaly (HP:0001433)2.79890011
54Recurrent viral infections (HP:0004429)2.78449632
55Joint hemorrhage (HP:0005261)2.77422264
56Osteomyelitis (HP:0002754)2.75329206
57Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.72237391
58Meningitis (HP:0001287)2.64972849
59Abnormality of T cells (HP:0002843)2.64027327
60Pulmonary infiltrates (HP:0002113)2.63342419
61Increased IgM level (HP:0003496)2.62699469
62Abnormality of the pleura (HP:0002103)2.61484870
63Thick nail (HP:0001805)2.61193697
64Upper motor neuron abnormality (HP:0002127)2.58759637
65Pustule (HP:0200039)2.52562481
66Glomerulonephritis (HP:0000099)2.49893427
67Hypochromic microcytic anemia (HP:0004840)2.46910268
68Loss of speech (HP:0002371)2.44043804
69Hypochromic anemia (HP:0001931)2.40063640
70Inflammation of the large intestine (HP:0002037)2.36680008
71Poor head control (HP:0002421)2.35932953
72Recurrent lower respiratory tract infections (HP:0002783)2.34834937
73Abnormality of the peritoneum (HP:0002585)2.32509797
74Urinary glycosaminoglycan excretion (HP:0003541)2.31753291
75Mucopolysacchariduria (HP:0008155)2.31753291
76Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.30459421
77Gingival bleeding (HP:0000225)2.30459030
78Vertigo (HP:0002321)2.30324461
79Arterial thrombosis (HP:0004420)2.29525006
80Leukocytosis (HP:0001974)2.29473979
81Nausea (HP:0002018)2.27216090
82Glomerulopathy (HP:0100820)2.26493468
83Panhypogammaglobulinemia (HP:0003139)2.24252486
84Bone pain (HP:0002653)2.24161637
85Granulocytopenia (HP:0001913)2.22321705
86Polyneuropathy (HP:0001271)2.21735536
87Hypergammaglobulinemia (HP:0010702)2.20321407
88Gastrointestinal inflammation (HP:0004386)2.19161111
89Inappropriate behavior (HP:0000719)2.18154674
90Abnormality of polysaccharide metabolism (HP:0011012)2.14526999
91Abnormality of glycosaminoglycan metabolism (HP:0004371)2.14526999
92Abnormality of mucopolysaccharide metabolism (HP:0011020)2.14526999
93Keratitis (HP:0000491)2.13371500
94Keratoconjunctivitis sicca (HP:0001097)2.10467466
95Eosinophilia (HP:0001880)2.10433734
96Pathologic fracture (HP:0002756)2.10069365
97Petechiae (HP:0000967)2.09660058
98Premature loss of primary teeth (HP:0006323)2.07952228
99Abnormality of T cell physiology (HP:0011840)2.07589987
100Abnormality of the vasculature of the conjunctiva (HP:0008054)2.03842682
101Sepsis (HP:0100806)2.02627682
102Peripheral demyelination (HP:0011096)2.01362317
103Acne (HP:0001061)2.00529551
104Amaurosis fugax (HP:0100576)1.97689436
105Purpura (HP:0000979)1.97387016
106* Abnormality of the endocardium (HP:0004306)1.97092103
107Progressive visual loss (HP:0000529)1.96528295
108Chronic otitis media (HP:0000389)1.94200966
109Tetraparesis (HP:0002273)1.93560332
110Hematochezia (HP:0002573)1.92765829
111Spontaneous hematomas (HP:0007420)1.92430453
112Keratoconjunctivitis (HP:0001096)1.91130515
113Microcytic anemia (HP:0001935)1.91058128
114Abnormality of the pericardium (HP:0001697)1.90846066
115Acute hepatic failure (HP:0006554)1.89528104
116Viral hepatitis (HP:0006562)1.88582221
117Colitis (HP:0002583)1.88501795
118Thrombophlebitis (HP:0004418)1.88165690
119Increased serum ferritin (HP:0003281)1.88020226
120Gastrointestinal infarctions (HP:0005244)1.88011257
121Anorexia (HP:0002039)1.87835035
122Nephritis (HP:0000123)1.87117758
123Albinism (HP:0001022)1.86751564
124Abnormality of the prostate (HP:0008775)1.84927524
125Bone cyst (HP:0012062)1.83851300
126Lymphopenia (HP:0001888)1.83158846
127Arthralgia (HP:0002829)1.81814307
128Diminished motivation (HP:0000745)1.80946174
129* Skin ulcer (HP:0200042)1.80712756
130Recurrent bronchitis (HP:0002837)1.80568698
131Abnormality of iron homeostasis (HP:0011031)1.80118484
132J-shaped sella turcica (HP:0002680)1.80028501
133Osteolytic defects of the hand bones (HP:0009699)1.79862316
134Osteolytic defects of the phalanges of the hand (HP:0009771)1.79862316
135Abnormality of the lumbar spine (HP:0100712)1.79379297
136Segmental peripheral demyelination/remyelination (HP:0003481)1.79185391
137Gangrene (HP:0100758)1.78637198
138Abnormality of T cell number (HP:0011839)1.77524372
139Epistaxis (HP:0000421)1.75907962
140Apathy (HP:0000741)1.73314440
141Conjunctival telangiectasia (HP:0000524)1.71496639
142Menorrhagia (HP:0000132)1.71019465
143Personality changes (HP:0000751)1.70896452

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK5.19421257
2RIPK45.04362955
3BLK4.04330840
4MAP3K143.90036495
5IRAK43.16724788
6TBK13.10207557
7IRAK32.76865089
8TYK22.53977098
9MAP4K12.34741249
10IKBKB2.19181689
11ERN12.17479250
12PIM22.03709260
13IKBKE1.97800368
14GRK61.92288841
15TNK21.87155268
16KIT1.86197546
17TXK1.82891278
18ABL21.81959112
19JAK11.81454844
20CSK1.66642848
21JAK31.64703948
22NME21.61620865
23PRPF4B1.53856672
24MST41.46718491
25EPHB11.45905408
26MST1R1.45245881
27FGR1.39176453
28SYK1.36774920
29NEK91.34425491
30HCK1.31140655
31MATK1.30861719
32TAOK11.29050077
33BMX1.25997828
34TGFBR21.24280566
35ERBB31.24255695
36JAK21.20433107
37CHUK1.19967300
38LYN1.18429390
39BMPR21.18214997
40TRPM71.18103536
41GRK71.17099668
42MAP3K131.16850741
43RPS6KA41.15429423
44ZAP701.12762924
45EPHA31.11427598
46TAOK31.09386028
47STK41.02883682
48BTK1.01678059
49PIK3CG1.00862334
50TEC1.00549886
51CSF1R1.00202394
52IRAK10.99189965
53PIM10.98958022
54CLK10.95130093
55CAMKK20.93820228
56LCK0.93277441
57YES10.91602425
58MARK30.80746395
59FRK0.80126244
60PRKCD0.78145165
61FGFR30.76607238
62MARK20.76555177
63IRAK20.75786717
64CDK190.75524087
65STK100.71639799
66MAP3K110.70137254
67MAP3K60.69807273
68PTK2B0.69745726
69ACVR1B0.69438071
70ABL10.69227806
71MAP2K30.67408101
72EGFR0.67221454
73FES0.66764089
74EIF2AK20.62950019
75KSR10.61190925
76SGK30.60413047
77MAP2K40.58547155
78SGK20.58123111
79ARAF0.57521087
80STK110.57429408
81MAPK70.57007341
82TRIB30.55706051
83ADRBK20.55654673
84FGFR40.54921846
85MAPK120.54187884
86ITK0.52479705
87MAP3K50.52382990
88WNK10.51888002
89PRKD20.49735306
90RAF10.49508267
91MAP3K70.48932944
92SIK20.48495364
93STK240.48163159
94MAP3K10.46676850
95MAP2K60.46558118
96MAP3K120.45437765
97RIPK10.44013010
98PRKCQ0.43974588
99LRRK20.43591249
100MAP3K30.43287845
101DYRK1B0.42826469
102STK30.41957487
103CDC42BPA0.40975945
104CAMKK10.40099688
105MAP3K20.39999221
106HIPK20.38756910
107BMPR1B0.38536637
108NLK0.38492681
109MOS0.37776589
110ERBB40.37721686
111SCYL20.35468276
112RPS6KL10.35397592
113CAMK1D0.34779242
114CDK60.34717867
115KSR20.34457201
116RPS6KA60.34231010
117CAMK40.34164916
118FYN0.33953874
119DAPK30.32305933
120RET0.31957733
121PDGFRB0.31873185
122TAOK20.31787115
123PTK60.30205347
124DYRK30.29593047
125DAPK20.29203000
126TESK10.29032619
127PRKCZ0.27812084
128MAP3K100.27557486
129MAPKAPK20.27204092
130TTN0.25439983
131PDPK10.25177089
132PDK10.24459378
133SIK30.24042429
134INSR0.23590894
135RPS6KC10.22242484

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.57902452
2Staphylococcus aureus infection_Homo sapiens_hsa051503.02756149
3Graft-versus-host disease_Homo sapiens_hsa053323.01581223
4Rheumatoid arthritis_Homo sapiens_hsa053232.81109174
5Toll-like receptor signaling pathway_Homo sapiens_hsa046202.74471426
6Lysosome_Homo sapiens_hsa041422.66244350
7Osteoclast differentiation_Homo sapiens_hsa043802.61495708
8Legionellosis_Homo sapiens_hsa051342.59174283
9* Tuberculosis_Homo sapiens_hsa051522.55028734
10* Phagosome_Homo sapiens_hsa041452.40405340
11NF-kappa B signaling pathway_Homo sapiens_hsa040642.37695198
12Malaria_Homo sapiens_hsa051442.35226745
13Pertussis_Homo sapiens_hsa051332.32168238
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.32092203
15NOD-like receptor signaling pathway_Homo sapiens_hsa046212.17286121
16Allograft rejection_Homo sapiens_hsa053302.11534853
17Asthma_Homo sapiens_hsa053102.02172703
18RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.93574450
19Collecting duct acid secretion_Homo sapiens_hsa049661.88951870
20Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.87092329
21Salmonella infection_Homo sapiens_hsa051321.85798367
22Measles_Homo sapiens_hsa051621.82156121
23Type I diabetes mellitus_Homo sapiens_hsa049401.69547234
24TNF signaling pathway_Homo sapiens_hsa046681.65023620
25Influenza A_Homo sapiens_hsa051641.59309278
26Glycosaminoglycan degradation_Homo sapiens_hsa005311.57560003
27Intestinal immune network for IgA production_Homo sapiens_hsa046721.57214177
28Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.54687384
29Other glycan degradation_Homo sapiens_hsa005111.52605672
30Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.51291145
31Hematopoietic cell lineage_Homo sapiens_hsa046401.50760240
32B cell receptor signaling pathway_Homo sapiens_hsa046621.47018675
33Toxoplasmosis_Homo sapiens_hsa051451.46221355
34Chemokine signaling pathway_Homo sapiens_hsa040621.45326545
35Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.41238244
36Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.40862554
37African trypanosomiasis_Homo sapiens_hsa051431.34256073
38Apoptosis_Homo sapiens_hsa042101.30762009
39Shigellosis_Homo sapiens_hsa051311.25501787
40Antigen processing and presentation_Homo sapiens_hsa046121.25036054
41Jak-STAT signaling pathway_Homo sapiens_hsa046301.22062499
42Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.21447497
43Herpes simplex infection_Homo sapiens_hsa051681.13607239
44Complement and coagulation cascades_Homo sapiens_hsa046101.09694360
45Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.08376851
46Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.03867659
47Viral myocarditis_Homo sapiens_hsa054160.97531929
48Amoebiasis_Homo sapiens_hsa051460.96414009
49Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.96302397
50Hepatitis B_Homo sapiens_hsa051610.96250736
51Leukocyte transendothelial migration_Homo sapiens_hsa046700.96180361
52AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.95379268
53Autoimmune thyroid disease_Homo sapiens_hsa053200.90276733
54Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.90162707
55Non-small cell lung cancer_Homo sapiens_hsa052230.86707557
56Hepatitis C_Homo sapiens_hsa051600.85742169
57Vibrio cholerae infection_Homo sapiens_hsa051100.82336761
58Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.78797189
59SNARE interactions in vesicular transport_Homo sapiens_hsa041300.77364377
60Acute myeloid leukemia_Homo sapiens_hsa052210.71169527
61Steroid biosynthesis_Homo sapiens_hsa001000.67114428
62Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.66528371
63Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.66241364
64Primary immunodeficiency_Homo sapiens_hsa053400.64681687
65Platelet activation_Homo sapiens_hsa046110.63787262
66T cell receptor signaling pathway_Homo sapiens_hsa046600.63698140
67Pentose and glucuronate interconversions_Homo sapiens_hsa000400.58733067
68Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.57404920
69Regulation of autophagy_Homo sapiens_hsa041400.56673650
70Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.55351953
71Prion diseases_Homo sapiens_hsa050200.55030607
72Prolactin signaling pathway_Homo sapiens_hsa049170.51943835
73Phospholipase D signaling pathway_Homo sapiens_hsa040720.50964736
74Neurotrophin signaling pathway_Homo sapiens_hsa047220.50236942
75Pancreatic cancer_Homo sapiens_hsa052120.48326545
76Sphingolipid signaling pathway_Homo sapiens_hsa040710.48097146
77Mineral absorption_Homo sapiens_hsa049780.47850641
78GnRH signaling pathway_Homo sapiens_hsa049120.47829980
79Chronic myeloid leukemia_Homo sapiens_hsa052200.46602564
80Renin-angiotensin system_Homo sapiens_hsa046140.45613298
81Adipocytokine signaling pathway_Homo sapiens_hsa049200.45609584
82Notch signaling pathway_Homo sapiens_hsa043300.44521117
83Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.42710344
84Sphingolipid metabolism_Homo sapiens_hsa006000.41695365
85Phosphatidylinositol signaling system_Homo sapiens_hsa040700.41467928
86Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.38377156
87Choline metabolism in cancer_Homo sapiens_hsa052310.37697026
88Epstein-Barr virus infection_Homo sapiens_hsa051690.37298236
89Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.37232421
90Synaptic vesicle cycle_Homo sapiens_hsa047210.37106454
91MAPK signaling pathway_Homo sapiens_hsa040100.33760202
92Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.33601037
93HTLV-I infection_Homo sapiens_hsa051660.33166761
94Inositol phosphate metabolism_Homo sapiens_hsa005620.32834489
95HIF-1 signaling pathway_Homo sapiens_hsa040660.32598104
96Endometrial cancer_Homo sapiens_hsa052130.32552884
97Type II diabetes mellitus_Homo sapiens_hsa049300.32302855
98mTOR signaling pathway_Homo sapiens_hsa041500.31274657
99Endocytosis_Homo sapiens_hsa041440.30828684
100Regulation of actin cytoskeleton_Homo sapiens_hsa048100.30281284
101Glycerophospholipid metabolism_Homo sapiens_hsa005640.29813625
102Proteoglycans in cancer_Homo sapiens_hsa052050.29517149
103Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.27750891
104Caffeine metabolism_Homo sapiens_hsa002320.27619426
105Viral carcinogenesis_Homo sapiens_hsa052030.26792518
106Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.26211508
107Rap1 signaling pathway_Homo sapiens_hsa040150.26159018
108Dorso-ventral axis formation_Homo sapiens_hsa043200.25426125
109Arachidonic acid metabolism_Homo sapiens_hsa005900.23534910
110Transcriptional misregulation in cancer_Homo sapiens_hsa052020.22358890
111Insulin resistance_Homo sapiens_hsa049310.21396890
112VEGF signaling pathway_Homo sapiens_hsa043700.19954972
113Histidine metabolism_Homo sapiens_hsa003400.19907102
114Carbohydrate digestion and absorption_Homo sapiens_hsa049730.17778073
115Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.16732894
116FoxO signaling pathway_Homo sapiens_hsa040680.13119960
117Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.11937114
118Ether lipid metabolism_Homo sapiens_hsa005650.07876258
119Renal cell carcinoma_Homo sapiens_hsa052110.07405521

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