CLEC9A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: CLEC9A is a group V C-type lectin-like receptor (CTLR) that functions as an activation receptor and is expressed on myeloid lineage cells (Huysamen et al., 2008 [PubMed 18408006]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation by organism of defense response of other organism involved in symbiotic interact7.44053486
2modulation by symbiont of host immune response (GO:0052553)7.44053486
3positive regulation by symbiont of host defense response (GO:0052509)7.44053486
4modulation by symbiont of host defense response (GO:0052031)7.44053486
5modulation by organism of immune response of other organism involved in symbiotic interaction (GO:007.44053486
6modulation by organism of defense response of other organism involved in symbiotic interaction (GO:07.44053486
7regulation of phospholipase A2 activity (GO:0032429)7.08620375
8cellular response to exogenous dsRNA (GO:0071360)6.30446806
9pinocytosis (GO:0006907)6.26113461
10microglial cell activation (GO:0001774)6.21451847
11intracellular pH reduction (GO:0051452)5.75614234
12glycosphingolipid catabolic process (GO:0046479)5.58103335
13positive regulation of interferon-alpha production (GO:0032727)5.53823934
14regulation of antigen processing and presentation of peptide antigen (GO:0002583)5.53123608
15antigen processing and presentation of endogenous antigen (GO:0019883)5.33566020
16regulation of interferon-beta biosynthetic process (GO:0045357)5.28565682
17positive regulation of mast cell degranulation (GO:0043306)5.24380065
18positive regulation of mast cell activation involved in immune response (GO:0033008)5.24380065
19sphingolipid catabolic process (GO:0030149)5.23746773
20histamine secretion (GO:0001821)5.22462282
21regulation of interferon-alpha production (GO:0032647)5.13576184
22membrane raft organization (GO:0031579)5.04865879
23glycolipid catabolic process (GO:0019377)4.99614570
24regulation of B cell receptor signaling pathway (GO:0050855)4.99297939
25hemoglobin metabolic process (GO:0020027)4.97312940
26regulation of T cell tolerance induction (GO:0002664)4.93336627
27response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.84102712
28response to host immune response (GO:0052572)4.84102712
29positive regulation of chemokine biosynthetic process (GO:0045080)4.82380649
30positive regulation of type 2 immune response (GO:0002830)4.79841514
31membrane lipid catabolic process (GO:0046466)4.70470759
32T cell costimulation (GO:0031295)4.68895084
33negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)4.67220077
34macrophage activation involved in immune response (GO:0002281)4.63841619
35lymphocyte costimulation (GO:0031294)4.63030215
36pH reduction (GO:0045851)4.54018630
37ceramide catabolic process (GO:0046514)4.52847746
38regulation of tolerance induction (GO:0002643)4.48652889
39iron ion import (GO:0097286)4.48146759
40positive regulation of mast cell activation (GO:0033005)4.41396182
41antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.39891258
42antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.39891258
43B cell mediated immunity (GO:0019724)4.30154326
44response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.27705132
45response to host (GO:0075136)4.27705132
46response to host defenses (GO:0052200)4.27705132
47membrane budding (GO:0006900)4.26217209
48import into cell (GO:0098657)4.15584602
49histamine transport (GO:0051608)4.13759791
50positive regulation of myeloid leukocyte mediated immunity (GO:0002888)4.11888897
51oligosaccharide catabolic process (GO:0009313)4.10150536
52regulation of alpha-beta T cell proliferation (GO:0046640)4.05680900
53response to peptidoglycan (GO:0032494)4.05603015
54response to interferon-gamma (GO:0034341)4.02369280
55respiratory burst (GO:0045730)3.97902095
56detection of molecule of bacterial origin (GO:0032490)3.96529132
57G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.95845349
58regulation of dendritic cell antigen processing and presentation (GO:0002604)3.95178815
59cellular response to interferon-beta (GO:0035458)3.92245923
60thrombin receptor signaling pathway (GO:0070493)3.89700989
61early endosome to late endosome transport (GO:0045022)3.86997217
62positive regulation of interleukin-12 production (GO:0032735)3.82731692
63T cell receptor signaling pathway (GO:0050852)3.80031162
64response to muramyl dipeptide (GO:0032495)3.79263761
65negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.74262022
66macrophage activation (GO:0042116)3.72718187
67G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.70339345
68GPI anchor biosynthetic process (GO:0006506)3.66481733
69antigen receptor-mediated signaling pathway (GO:0050851)3.65275935
70regulation of T-helper 2 cell differentiation (GO:0045628)3.65091185
71negative regulation of B cell proliferation (GO:0030889)3.61422746
72regulation of chemokine biosynthetic process (GO:0045073)3.54408281
73grooming behavior (GO:0007625)3.52089538
74regulation of mast cell activation (GO:0033003)3.49855478
75cellular extravasation (GO:0045123)3.48127277
76I-kappaB phosphorylation (GO:0007252)3.46156739
77regulation of mast cell degranulation (GO:0043304)3.44602380
78behavioral response to ethanol (GO:0048149)3.41427141
79defense response to protozoan (GO:0042832)3.40863290
80positive regulation of monocyte chemotaxis (GO:0090026)3.40447146
81positive regulation of interferon-gamma production (GO:0032729)3.39035546
82ribosomal large subunit biogenesis (GO:0042273)3.38280385
83membrane invagination (GO:0010324)3.38055864
84positive regulation of toll-like receptor signaling pathway (GO:0034123)3.36207261
85positive regulation of T cell mediated cytotoxicity (GO:0001916)3.33001160
86positive regulation of antigen processing and presentation (GO:0002579)3.32897293
87mitochondrial fragmentation involved in apoptotic process (GO:0043653)3.32245203
88adenosine receptor signaling pathway (GO:0001973)3.32215828
89positive regulation of leukocyte degranulation (GO:0043302)3.29575170
90Arp2/3 complex-mediated actin nucleation (GO:0034314)3.27441974
91antigen processing and presentation via MHC class Ib (GO:0002475)3.25750955
92positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.24370590
93neutrophil activation involved in immune response (GO:0002283)3.22872207
94regulation of intracellular pH (GO:0051453)3.19697887
95pantothenate metabolic process (GO:0015939)3.19609844
96regulation of mast cell activation involved in immune response (GO:0033006)3.19413205
97GPI anchor metabolic process (GO:0006505)3.17510279
98myeloid dendritic cell activation (GO:0001773)3.17209997
99autophagic vacuole fusion (GO:0000046)3.16863280
100positive regulation of tolerance induction (GO:0002645)3.13770616
101detection of external biotic stimulus (GO:0098581)3.12130506
102purinergic receptor signaling pathway (GO:0035587)3.10875321
103negative regulation of nitric-oxide synthase activity (GO:0051001)3.06788751
104positive regulation of T cell proliferation (GO:0042102)3.06563847
105positive regulation of interleukin-17 production (GO:0032740)3.05053422
106tryptophan catabolic process (GO:0006569)3.04845595
107indole-containing compound catabolic process (GO:0042436)3.04845595
108indolalkylamine catabolic process (GO:0046218)3.04845595
109positive regulation of interferon-beta production (GO:0032728)3.03465631
110negative regulation of B cell activation (GO:0050869)3.01357648
111GTP biosynthetic process (GO:0006183)3.00481750
112cellular protein catabolic process (GO:0044257)2.97958013
113actin nucleation (GO:0045010)2.96408590
114regulation of type 2 immune response (GO:0002828)2.94998565
115kynurenine metabolic process (GO:0070189)2.93344324
116regulation of interleukin-12 production (GO:0032655)2.93223577
117interferon-gamma-mediated signaling pathway (GO:0060333)2.93000628
118germinal center formation (GO:0002467)2.92407189
119positive thymic T cell selection (GO:0045059)2.92070663
120fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.90037402
121regulation of cellular pH (GO:0030641)2.89846344
122positive regulation of interleukin-8 secretion (GO:2000484)2.88564550
123cellular response to dsRNA (GO:0071359)2.88400084
124T-helper 1 type immune response (GO:0042088)2.85787351
125response to protozoan (GO:0001562)2.84669593
126production of molecular mediator involved in inflammatory response (GO:0002532)2.83868645
127apoptotic DNA fragmentation (GO:0006309)2.83402042
128immunoglobulin mediated immune response (GO:0016064)2.82938938
129myeloid cell activation involved in immune response (GO:0002275)2.82677185
130regulation of T cell mediated cytotoxicity (GO:0001914)2.82586653
131glycoside metabolic process (GO:0016137)2.81380609
132detection of biotic stimulus (GO:0009595)2.80673203
133response to interferon-beta (GO:0035456)2.79817546
134regulation of monocyte chemotaxis (GO:0090025)2.76441622
135cellular response to interferon-gamma (GO:0071346)2.74697061
136positive regulation of smooth muscle cell migration (GO:0014911)2.74417259
137lipid storage (GO:0019915)2.74235732
138surfactant homeostasis (GO:0043129)2.74230444
139antigen processing and presentation of peptide antigen via MHC class II (GO:0002495)2.73357807
140antigen processing and presentation of peptide or polysaccharide antigen via MHC class II (GO:0002502.73357807
141tryptophan metabolic process (GO:0006568)2.73345334
142termination of RNA polymerase III transcription (GO:0006386)2.72697813
143transcription elongation from RNA polymerase III promoter (GO:0006385)2.72697813
144positive regulation of T cell activation (GO:0050870)2.72624019
145positive regulation of cellular amide metabolic process (GO:0034250)2.72057686
146negative regulation of alpha-beta T cell activation (GO:0046636)2.70766056
147mast cell activation (GO:0045576)2.68535086
148purinergic nucleotide receptor signaling pathway (GO:0035590)2.68381976
149regulation of antigen processing and presentation (GO:0002577)2.67965416
150antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.67300822
151lipoprotein metabolic process (GO:0042157)2.66647613
152positive regulation of lymphocyte proliferation (GO:0050671)2.65788143
153regulation of lymphocyte migration (GO:2000401)2.65245556
154localization within membrane (GO:0051668)2.64337540
155positive regulation of T cell differentiation in thymus (GO:0033089)2.64134860
156aromatic amino acid family catabolic process (GO:0009074)2.63089758
157positive regulation of mononuclear cell proliferation (GO:0032946)2.62727372
158regulation of T cell proliferation (GO:0042129)2.62646498
159modulation of growth of symbiont involved in interaction with host (GO:0044144)2.60552607
160regulation of growth of symbiont in host (GO:0044126)2.60552607
161negative regulation of growth of symbiont in host (GO:0044130)2.60552607
162negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.60552607
163cellular response to type I interferon (GO:0071357)2.59498916
164type I interferon signaling pathway (GO:0060337)2.59498916
165regulation of myeloid leukocyte mediated immunity (GO:0002886)2.59419172
166negative regulation of mast cell activation (GO:0033004)2.59178300
167Peyers patch development (GO:0048541)2.59159848
168phagocytosis, recognition (GO:0006910)2.58056016
169ganglioside metabolic process (GO:0001573)2.56496826
170positive regulation of macrophage cytokine production (GO:0060907)2.56150077
171response to type I interferon (GO:0034340)2.56066664
172positive regulation of T cell migration (GO:2000406)2.55073518
173cofactor transport (GO:0051181)2.54777072
174developmental programmed cell death (GO:0010623)2.54238776

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* IRF8_21731497_ChIP-ChIP_J774_Mouse5.91242725
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.98720735
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.97404968
4* IRF8_27001747_Chip-Seq_BMDM_Mouse3.93087370
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.90494556
6ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.78358147
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.69507898
8BP1_19119308_ChIP-ChIP_Hs578T_Human3.69399900
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.44044352
10CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.38224125
11GATA1_22025678_ChIP-Seq_K562_Human3.24092574
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.99008806
13SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.92749576
14RXR_22158963_ChIP-Seq_LIVER_Mouse2.71708628
15VDR_22108803_ChIP-Seq_LS180_Human2.71444083
16MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.56861166
17LXR_22158963_ChIP-Seq_LIVER_Mouse2.56153648
18PPARA_22158963_ChIP-Seq_LIVER_Mouse2.51215416
19NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.51021639
20* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.50609472
21EGR1_23403033_ChIP-Seq_LIVER_Mouse2.24129107
22SMAD_19615063_ChIP-ChIP_OVARY_Human2.12695846
23RUNX_20019798_ChIP-Seq_JUKART_Human2.10845955
24SCL_19346495_ChIP-Seq_HPC-7_Human2.08597649
25SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.05053343
26BRD4_27068464_Chip-Seq_AML-cells_Mouse2.04876128
27SPI1_23127762_ChIP-Seq_K562_Human2.02194302
28STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.93980168
29RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.82663935
30LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.80489108
31MYB_21317192_ChIP-Seq_ERMYB_Mouse1.78459064
32VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.75364664
33FLI1_27457419_Chip-Seq_LIVER_Mouse1.74734172
34FOXA1_21572438_ChIP-Seq_LNCaP_Human1.70473138
35NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.69562871
36IGF1R_20145208_ChIP-Seq_DFB_Human1.69167267
37RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.68836494
38ER_23166858_ChIP-Seq_MCF-7_Human1.64546696
39MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.64428259
40NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.62732653
41STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.62428571
42VDR_24787735_ChIP-Seq_THP-1_Human1.62243128
43GATA2_21666600_ChIP-Seq_HMVEC_Human1.61652827
44STAT4_19710469_ChIP-ChIP_TH1__Mouse1.61490948
45VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.55922522
46CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.55675003
47TAF15_26573619_Chip-Seq_HEK293_Human1.55357745
48POU3F2_20337985_ChIP-ChIP_501MEL_Human1.53445389
49NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.52590129
50PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.49483976
51PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.48401557
52MYB_26560356_Chip-Seq_TH2_Human1.47215841
53PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.43131601
54AR_21572438_ChIP-Seq_LNCaP_Human1.42347843
55AR_20517297_ChIP-Seq_VCAP_Human1.40980996
56IKZF1_21737484_ChIP-ChIP_HCT116_Human1.35082473
57PCGF2_27294783_Chip-Seq_ESCs_Mouse1.33339804
58CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.32381469
59* NANOG_19829295_ChIP-Seq_ESCs_Human1.31624847
60* SOX2_19829295_ChIP-Seq_ESCs_Human1.31624847
61MAF_26560356_Chip-Seq_TH1_Human1.31269426
62SPI1_23547873_ChIP-Seq_NB4_Human1.31010652
63PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.30750084
64* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.29077080
65SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.28997421
66PU_27001747_Chip-Seq_BMDM_Mouse1.28611303
67FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.28392380
68STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.27558599
69* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.26868402
70CDX2_19796622_ChIP-Seq_MESCs_Mouse1.26865983
71MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.26110027
72NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.25245578
73RUNX1_22412390_ChIP-Seq_EML_Mouse1.23954986
74GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.23668132
75GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.22178190
76VDR_23849224_ChIP-Seq_CD4+_Human1.21469269
77FOXA1_27270436_Chip-Seq_PROSTATE_Human1.18884783
78FOXA1_25329375_ChIP-Seq_VCAP_Human1.18884783
79EWS_26573619_Chip-Seq_HEK293_Human1.18042695
80EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.16056173
81CBP_20019798_ChIP-Seq_JUKART_Human1.15760556
82IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.15760556
83FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.14628502
84FOXH1_21741376_ChIP-Seq_EPCs_Human1.14466782
85PRDM14_20953172_ChIP-Seq_ESCs_Human1.13802935
86THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.11716006
87* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.11437014
88GATA1_19941827_ChIP-Seq_MEL_Mouse1.09488110
89PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08885642
90CIITA_25753668_ChIP-Seq_RAJI_Human1.08644052
91PCGF2_27294783_Chip-Seq_NPCs_Mouse1.07819441
92NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.07700728
93NRF2_20460467_ChIP-Seq_MEFs_Mouse1.07700728
94UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.07196528
95NFE2_27457419_Chip-Seq_LIVER_Mouse1.06641577
96STAT1_20625510_ChIP-Seq_HELA_Human1.06626118
97MYB_26560356_Chip-Seq_TH1_Human1.05669222
98FUS_26573619_Chip-Seq_HEK293_Human1.05289643
99BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.04543980
100PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.03426247
101SMRT_27268052_Chip-Seq_Bcells_Human1.02870966
102GATA6_21074721_ChIP-Seq_CACO-2_Human1.02293053
103GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.02199085
104GATA3_27048872_Chip-Seq_THYMUS_Human1.01652138
105RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.01135246
106EZH2_27294783_Chip-Seq_NPCs_Mouse1.01059301
107GATA3_26560356_Chip-Seq_TH2_Human1.00435724
108SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99260967
109CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99202467
110AR_25329375_ChIP-Seq_VCAP_Human0.98803908
111VDR_24763502_ChIP-Seq_THP-1_Human0.97798577
112FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.97652326
113TRIM28_21343339_ChIP-Seq_HEK293_Human0.97445704
114CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.96961763
115SPI1_20517297_ChIP-Seq_HL60_Human0.96696540
116PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.96667330
117FOXP3_21729870_ChIP-Seq_TREG_Human0.96378352
118FOXO3_23340844_ChIP-Seq_DLD1_Human0.95307475
119CMYC_18555785_Chip-Seq_ESCs_Mouse0.93798575
120FLI1_21867929_ChIP-Seq_TH2_Mouse0.93625975
121EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.93589966
122SUZ12_27294783_Chip-Seq_NPCs_Mouse0.92657228
123SALL4_22934838_ChIP-ChIP_CD34+_Human0.92088760
124RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.91982632
125CLOCK_20551151_ChIP-Seq_293T_Human0.91880905
126EGR1_19374776_ChIP-ChIP_THP-1_Human0.91438488
127BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.91392464
128CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91248554
129FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.91180025
130AUTS2_25519132_ChIP-Seq_293T-REX_Human0.89686023
131CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.89421599
132GATA3_26560356_Chip-Seq_TH1_Human0.88784332
133IRF1_19129219_ChIP-ChIP_H3396_Human0.88636605
134TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.88031650
135P300_18555785_Chip-Seq_ESCs_Mouse0.86702889
136GATA3_21878914_ChIP-Seq_MCF-7_Human0.86576234
137P300_19829295_ChIP-Seq_ESCs_Human0.86324020
138EGR1_19032775_ChIP-ChIP_M12_Human0.85389980
139GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85213609
140EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.84917882
141CRX_20693478_ChIP-Seq_RETINA_Mouse0.84913843
142GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84897305
143* TP53_22573176_ChIP-Seq_HFKS_Human0.84615207
144ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.84466858
145PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.84039366
146CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.82283909
147GATA2_22383799_ChIP-Seq_G1ME_Mouse0.81986328
148TBX20_22328084_ChIP-Seq_HEART_Mouse0.80194787
149TBX20_22080862_ChIP-Seq_HEART_Mouse0.80194787
150FOXA2_19822575_ChIP-Seq_HepG2_Human0.79594585
151TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.79115120
152TP53_16413492_ChIP-PET_HCT116_Human0.79111295
153EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.78733324
154TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.78297270
155PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.78057508
156CDX2_20551321_ChIP-Seq_CACO-2_Human0.76723866
157TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.76640280
158UTX_26944678_Chip-Seq_JUKART_Human0.76240696
159KDM2B_26808549_Chip-Seq_SUP-B15_Human0.75825366
160ESR1_21235772_ChIP-Seq_MCF-7_Human0.73124915
161TCF7_22412390_ChIP-Seq_EML_Mouse0.72102908
162CJUN_26792858_Chip-Seq_BT549_Human0.70326335
163SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.68764844
164PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.68558303
165* RARG_19884340_ChIP-ChIP_MEFs_Mouse0.67858853
166MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.67212147

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0001835_abnormal_antigen_presentation5.50511357
2MP0004147_increased_porphyrin_level4.93320857
3MP0005360_urolithiasis3.50011567
4MP0006082_CNS_inflammation3.42292896
5MP0004510_myositis2.87708442
6MP0002138_abnormal_hepatobiliary_system2.65713539
7MP0001853_heart_inflammation2.63494246
8MP0005671_abnormal_response_to2.62173594
9MP0002396_abnormal_hematopoietic_system2.56418292
10MP0002139_abnormal_hepatobiliary_system2.53425895
11MP0000685_abnormal_immune_system2.53294394
12MP0005085_abnormal_gallbladder_physiolo2.44338563
13MP0009785_altered_susceptibility_to2.39380566
14MP0004145_abnormal_muscle_electrophysio2.34440282
15MP0005464_abnormal_platelet_physiology2.30057281
16MP0005387_immune_system_phenotype2.20156397
17MP0001790_abnormal_immune_system2.20156397
18MP0002419_abnormal_innate_immunity2.17413041
19MP0005025_abnormal_response_to2.16153133
20MP0003436_decreased_susceptibility_to2.15607682
21MP0003303_peritoneal_inflammation2.11461879
22MP0003806_abnormal_nucleotide_metabolis2.10811895
23MP0002090_abnormal_vision2.01853281
24* MP0002452_abnormal_antigen_presenting2.00444373
25MP0003252_abnormal_bile_duct1.97965973
26MP0002148_abnormal_hypersensitivity_rea1.96625280
27MP0005167_abnormal_blood-brain_barrier1.92094695
28MP0003191_abnormal_cellular_cholesterol1.83353963
29MP0010368_abnormal_lymphatic_system1.80534222
30MP0009764_decreased_sensitivity_to1.79116078
31MP0001800_abnormal_humoral_immune1.78566164
32MP0002876_abnormal_thyroid_physiology1.77585982
33MP0003195_calcinosis1.76680987
34* MP0001819_abnormal_immune_cell1.72574128
35MP0005365_abnormal_bile_salt1.70034946
36MP0002723_abnormal_immune_serum1.66431410
37MP0008875_abnormal_xenobiotic_pharmacok1.65829898
38MP0003763_abnormal_thymus_physiology1.65690444
39MP0003828_pulmonary_edema1.65495891
40MP0006072_abnormal_retinal_apoptosis1.64837122
41MP0001879_abnormal_lymphatic_vessel1.62935552
42MP0002420_abnormal_adaptive_immunity1.62273634
43MP0005000_abnormal_immune_tolerance1.58985207
44MP0000343_altered_response_to1.58236940
45MP0001958_emphysema1.55842396
46MP0004782_abnormal_surfactant_physiolog1.50139320
47MP0004142_abnormal_muscle_tone1.50064565
48MP0010329_abnormal_lipoprotein_level1.44477188
49MP0003011_delayed_dark_adaptation1.43104101
50MP0002166_altered_tumor_susceptibility1.42957351
51MP0008961_abnormal_basal_metabolism1.40876826
52MP0003075_altered_response_to1.38282314
53MP0001986_abnormal_taste_sensitivity1.32772750
54MP0003866_abnormal_defecation1.32449006
55MP0003045_fibrosis1.29458911
56MP0000767_abnormal_smooth_muscle1.29304758
57MP0008469_abnormal_protein_level1.27480547
58MP0009840_abnormal_foam_cell1.27156508
59MP0006054_spinal_hemorrhage1.25571746
60MP0003724_increased_susceptibility_to1.24503412
61MP0005595_abnormal_vascular_smooth1.23872836
62MP0003300_gastrointestinal_ulcer1.20935484
63MP0003172_abnormal_lysosome_physiology1.20166617
64MP0006036_abnormal_mitochondrial_physio1.18265293
65MP0002405_respiratory_system_inflammati1.17673882
66MP0005165_increased_susceptibility_to1.17362527
67MP0001845_abnormal_inflammatory_respons1.17082642
68MP0005058_abnormal_lysosome_morphology1.15204203
69MP0003880_abnormal_central_pattern1.14915321
70MP0004019_abnormal_vitamin_homeostasis1.14598840
71MP0005451_abnormal_body_composition1.13688658
72MP0002277_abnormal_respiratory_mucosa1.13212802
73MP0000249_abnormal_blood_vessel1.13176117
74MP0005408_hypopigmentation1.12600140
75MP0004808_abnormal_hematopoietic_stem1.11065194
76MP0003705_abnormal_hypodermis_morpholog1.10385921
77MP0000716_abnormal_immune_system1.08869266
78MP0010155_abnormal_intestine_physiology1.08583356
79MP0002006_tumorigenesis1.08038494
80MP0006138_congestive_heart_failure1.04765275
81MP0002735_abnormal_chemical_nociception1.04539220
82MP0003183_abnormal_peptide_metabolism1.01752558
83MP0000609_abnormal_liver_physiology1.01400295
84MP0009765_abnormal_xenobiotic_induced0.99505906
85MP0003566_abnormal_cell_adhesion0.98849784
86MP0001663_abnormal_digestive_system0.98117324
87MP0002234_abnormal_pharynx_morphology0.97543686
88MP0000689_abnormal_spleen_morphology0.94714867
89MP0002928_abnormal_bile_duct0.94547857
90MP0002822_catalepsy0.94471298
91MP0001905_abnormal_dopamine_level0.94216863
92MP0005319_abnormal_enzyme/_coenzyme0.94163505
93MP0005385_cardiovascular_system_phenoty0.91658509
94MP0001544_abnormal_cardiovascular_syste0.91658509
95MP0002398_abnormal_bone_marrow0.91041658
96MP0009763_increased_sensitivity_to0.90173777
97MP0005670_abnormal_white_adipose0.89548497
98MP0003638_abnormal_response/metabolism_0.89145788
99MP0005253_abnormal_eye_physiology0.88649084
100MP0002429_abnormal_blood_cell0.87725292
101MP0005584_abnormal_enzyme/coenzyme_acti0.86690985
102MP0008004_abnormal_stomach_pH0.84243989
103MP0005166_decreased_susceptibility_to0.84016372
104MP0002837_dystrophic_cardiac_calcinosis0.83818557
105MP0002972_abnormal_cardiac_muscle0.83082461
106MP0008438_abnormal_cutaneous_collagen0.83058098
107MP0001533_abnormal_skeleton_physiology0.81715171
108MP0004084_abnormal_cardiac_muscle0.81538093
109MP0005551_abnormal_eye_electrophysiolog0.80661065
110MP0000598_abnormal_liver_morphology0.79336783
111MP0001440_abnormal_grooming_behavior0.78402388
112MP0002332_abnormal_exercise_endurance0.78251978
113MP0000371_diluted_coat_color0.78030723
114MP0003950_abnormal_plasma_membrane0.76982922
115MP0009379_abnormal_foot_pigmentation0.76165648
116MP0009697_abnormal_copulation0.75958724
117MP0008872_abnormal_physiological_respon0.75934306
118MP0001873_stomach_inflammation0.75615817
119MP0001666_abnormal_nutrient_absorption0.75538651
120MP0005075_abnormal_melanosome_morpholog0.75233246
121MP0002118_abnormal_lipid_homeostasis0.74823300
122MP0003186_abnormal_redox_activity0.74183641
123MP0008775_abnormal_heart_ventricle0.73234054
124MP0001970_abnormal_pain_threshold0.73011949
125MP0001529_abnormal_vocalization0.71887768
126MP0005084_abnormal_gallbladder_morpholo0.69424994
127MP0004036_abnormal_muscle_relaxation0.69176416
128MP0009643_abnormal_urine_homeostasis0.68286741
129MP0009278_abnormal_bone_marrow0.67217972
130MP0009333_abnormal_splenocyte_physiolog0.67147301
131MP0010386_abnormal_urinary_bladder0.65782333
132MP0005535_abnormal_body_temperature0.65320439
133MP0001664_abnormal_digestion0.65115454
134MP0010630_abnormal_cardiac_muscle0.63921892
135MP0001545_abnormal_hematopoietic_system0.62500907
136MP0005397_hematopoietic_system_phenotyp0.62500907
137MP0002722_abnormal_immune_system0.62297569
138MP0000465_gastrointestinal_hemorrhage0.61849029
139MP0002733_abnormal_thermal_nociception0.57742633
140MP0004947_skin_inflammation0.56766500
141MP0002132_abnormal_respiratory_system0.56729891
142MP0002638_abnormal_pupillary_reflex0.55785068
143MP0000703_abnormal_thymus_morphology0.54553724

Predicted human phenotypes

RankGene SetZ-score
1Increased neuronal autofluorescent lipopigment (HP:0002074)8.18898462
2Cerebral palsy (HP:0100021)7.85724487
3Increased cerebral lipofuscin (HP:0011813)7.51115957
4Testicular atrophy (HP:0000029)6.33489214
5Loss of speech (HP:0002371)5.97299464
6Abnormality of complement system (HP:0005339)5.43857496
7Obstructive lung disease (HP:0006536)5.38792804
8Chronic obstructive pulmonary disease (HP:0006510)5.38792804
9Acrocyanosis (HP:0001063)4.57596519
10Nephritis (HP:0000123)4.34343386
11Abnormality of glycosphingolipid metabolism (HP:0004343)4.26656773
12Abnormality of glycolipid metabolism (HP:0010969)4.26656773
13Abnormality of liposaccharide metabolism (HP:0010968)4.26656773
14Arthropathy (HP:0003040)4.25388434
15Dynein arm defect of respiratory motile cilia (HP:0012255)4.18988325
16Absent/shortened dynein arms (HP:0200106)4.18988325
17Recurrent abscess formation (HP:0002722)4.05489977
18Decreased electroretinogram (ERG) amplitude (HP:0000654)4.01819225
19Abnormality of the pleura (HP:0002103)3.97840212
20Hemoptysis (HP:0002105)3.93741172
21Split foot (HP:0001839)3.84304297
22Abolished electroretinogram (ERG) (HP:0000550)3.81146320
23Recurrent bacterial skin infections (HP:0005406)3.74979155
24Recurrent gram-negative bacterial infections (HP:0005420)3.69359163
25Eczematoid dermatitis (HP:0000976)3.64989257
26Chronic otitis media (HP:0000389)3.64190058
27Ureteral stenosis (HP:0000071)3.48314998
28Multiple enchondromatosis (HP:0005701)3.28810008
29Mucosal telangiectasiae (HP:0100579)3.25122046
30Ureteral obstruction (HP:0006000)3.22108303
31Xerostomia (HP:0000217)3.16671153
32Emphysema (HP:0002097)3.13893783
33Vasculitis (HP:0002633)3.12293494
34Azoospermia (HP:0000027)3.10612053
35Increased serum ferritin (HP:0003281)3.09577584
36Chest pain (HP:0100749)3.01090676
37Aplastic anemia (HP:0001915)3.00171287
38Abnormality of male internal genitalia (HP:0000022)2.99468442
39Hypoproteinemia (HP:0003075)2.99228441
40Anorexia (HP:0002039)2.95950490
41Abnormality of iron homeostasis (HP:0011031)2.91691724
42Spinal cord lesions (HP:0100561)2.91467321
43Syringomyelia (HP:0003396)2.91467321
44Meningitis (HP:0001287)2.90817546
45Abnormal glucose tolerance (HP:0001952)2.90178609
46Recurrent cutaneous fungal infections (HP:0011370)2.90087880
47Chronic mucocutaneous candidiasis (HP:0002728)2.90087880
48Skin rash (HP:0000988)2.89345574
49Hepatocellular carcinoma (HP:0001402)2.82676152
50Chin dimple (HP:0010751)2.77364455
51Abnormality of the pericardium (HP:0001697)2.76110978
52Gangrene (HP:0100758)2.74965887
53Abnormality of binocular vision (HP:0011514)2.74103967
54Diplopia (HP:0000651)2.74103967
553-Methylglutaconic aciduria (HP:0003535)2.69492434
56Deep venous thrombosis (HP:0002625)2.65759745
57Methylmalonic acidemia (HP:0002912)2.65620341
58Hematochezia (HP:0002573)2.65180574
59Cardiomegaly (HP:0001640)2.61786754
60Poor head control (HP:0002421)2.60588046
61Glomerulopathy (HP:0100820)2.58926030
62Epistaxis (HP:0000421)2.54152694
63Abnormality of macrophages (HP:0004311)2.53235664
64Abnormality of the nasal mucosa (HP:0000433)2.50027357
65Panhypogammaglobulinemia (HP:0003139)2.48644775
66Myocardial infarction (HP:0001658)2.48629418
67Apathy (HP:0000741)2.48325244
68Restrictive lung disease (HP:0002091)2.48284385
69Paralysis (HP:0003470)2.48117273
70Recurrent skin infections (HP:0001581)2.47668946
71Absent rod-and cone-mediated responses on ERG (HP:0007688)2.47235049
72Macular degeneration (HP:0000608)2.45119110
73Abnormality of transition element cation homeostasis (HP:0011030)2.44696886
74Polycythemia (HP:0001901)2.37105020
75Absent frontal sinuses (HP:0002688)2.36487411
76Cheilitis (HP:0100825)2.36300661
77Amyloidosis (HP:0011034)2.35576861
78Pulmonary infiltrates (HP:0002113)2.34829480
79Diminished motivation (HP:0000745)2.34470037
80Ascites (HP:0001541)2.34449893
81Abnormal ciliary motility (HP:0012262)2.33217238
82Progressive visual loss (HP:0000529)2.32801111
83Increased IgM level (HP:0003496)2.31370800
84Polyneuropathy (HP:0001271)2.30166383
85Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.29317546
86Short 1st metacarpal (HP:0010034)2.29317546
87Spontaneous hematomas (HP:0007420)2.28733344
88Agammaglobulinemia (HP:0004432)2.27405745
89Recurrent sinusitis (HP:0011108)2.25912346
90Xanthomatosis (HP:0000991)2.25857674
91Enlarged epiphyses (HP:0010580)2.25481420
92Mitral stenosis (HP:0001718)2.25165723
93Constricted visual fields (HP:0001133)2.24502797
94Abnormality of aspartate family amino acid metabolism (HP:0010899)2.22741675
95Hepatocellular necrosis (HP:0001404)2.21938126
96Progressive microcephaly (HP:0000253)2.21152574
97Ankyloglossia (HP:0010296)2.19188533
98Granulocytopenia (HP:0001913)2.19106802
99Interstitial pulmonary disease (HP:0006530)2.18961565
100Abnormal respiratory epithelium morphology (HP:0012253)2.17613949
101Abnormal respiratory motile cilium morphology (HP:0005938)2.17613949
102Acute necrotizing encephalopathy (HP:0006965)2.14836135
103Neoplasm of the colon (HP:0100273)2.12917372
104Abnormality of B cell number (HP:0010975)2.12694951
105Radial bowing (HP:0002986)2.10041311
106Mitochondrial inheritance (HP:0001427)2.10026260
107Abnormality of the 1st metacarpal (HP:0010009)2.09448623
108Abnormal spermatogenesis (HP:0008669)2.08681244
109Eosinophilia (HP:0001880)2.07256607
110Increased hepatocellular lipid droplets (HP:0006565)2.05329452
111Congenital, generalized hypertrichosis (HP:0004540)2.05083475
112Paresthesia (HP:0003401)2.04945080
113Urticaria (HP:0001025)2.04610638
114Prolonged partial thromboplastin time (HP:0003645)2.04066543
115Recurrent fungal infections (HP:0002841)2.03777622
116Joint hemorrhage (HP:0005261)2.03202250
117Median cleft lip (HP:0000161)2.02154256
118Amaurosis fugax (HP:0100576)1.99623941
119Nasal polyposis (HP:0100582)1.99509264
120Exertional dyspnea (HP:0002875)1.98310832
121Vacuolated lymphocytes (HP:0001922)1.97638913
122Hematuria (HP:0000790)1.96686466
123Hypercholesterolemia (HP:0003124)1.95582991
124Pancreatitis (HP:0001733)1.95498230
125Complement deficiency (HP:0004431)1.95285559
126Intrahepatic cholestasis (HP:0001406)1.94587140
127Esophageal varix (HP:0002040)1.94540541
128Increased CSF lactate (HP:0002490)1.94495216
129Abnormal mitochondria in muscle tissue (HP:0008316)1.94360788
130Pruritus (HP:0000989)1.94339317
131Hyperlipoproteinemia (HP:0010980)1.94089502
132Abnormality of methionine metabolism (HP:0010901)1.91599993
133Colitis (HP:0002583)1.89838371
134Mediastinal lymphadenopathy (HP:0100721)1.89689020
135Gingival bleeding (HP:0000225)1.89350133
136Elevated erythrocyte sedimentation rate (HP:0003565)1.88415257
137Gastrointestinal infarctions (HP:0005244)1.88395439
138Amelogenesis imperfecta (HP:0000705)1.87105353
139Myotonia (HP:0002486)1.86731291
140Progressive macrocephaly (HP:0004481)1.86471016
141Pulmonary fibrosis (HP:0002206)1.86279737
142Thrombophlebitis (HP:0004418)1.85285161
143Recurrent viral infections (HP:0004429)1.84726565
144Abnormality of monocarboxylic acid metabolism (HP:0010996)1.84715791
145Abnormal rod and cone electroretinograms (HP:0008323)1.84643909
146Cerebral hemorrhage (HP:0001342)1.82310827
147Methylmalonic aciduria (HP:0012120)1.81410315
148Distal arthrogryposis (HP:0005684)1.80738346
149Gingivitis (HP:0000230)1.80519893
150Stomatitis (HP:0010280)1.78583591
151Epidermoid cyst (HP:0200040)1.77943679
152Fatigue (HP:0012378)1.77287764
153Cleft eyelid (HP:0000625)1.76648827
154Short phalanx of the thumb (HP:0009660)1.76584662
155Abnormality of aromatic amino acid family metabolism (HP:0004338)1.76279150
156Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.73057294
157Pulmonary embolism (HP:0002204)1.71477881
158Abnormality of the prostate (HP:0008775)1.70015233
159Vertigo (HP:0002321)1.69459137
160Hypertensive crisis (HP:0100735)1.68218823
161Metaphyseal dysplasia (HP:0100255)1.66843770
162Generalized hyperpigmentation (HP:0007440)1.66585368
163Myositis (HP:0100614)1.65302086
164J-shaped sella turcica (HP:0002680)1.64677807
165Arterial thrombosis (HP:0004420)1.63947468

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.85556853
2EIF2AK34.18337085
3STK163.98832227
4TAOK23.61317063
5MAP3K123.40483394
6CSF1R3.22968748
7TBK13.03467001
8TYK23.02693819
9MAP3K142.87757716
10TIE12.63124402
11KIT2.47047073
12IRAK32.38864394
13NUAK12.35114436
14TLK12.32496760
15MAP4K22.27505886
16IRAK42.27244610
17FLT32.23317515
18GRK12.20541429
19FGFR42.20422681
20EPHB12.14859124
21CSK1.99913332
22BMPR1B1.92930813
23MYLK1.89380224
24KDR1.87804890
25PIK3CG1.86983776
26IKBKB1.84987690
27TAOK31.75996006
28BLK1.72484025
29JAK11.68046915
30SYK1.53889724
31STK241.50352024
32MAP2K31.48635492
33PRKG21.40499229
34MAP3K51.38872765
35TGFBR21.38650578
36JAK31.33532783
37FRK1.33372633
38MAP2K61.28969714
39TEC1.27253042
40FGFR31.26351437
41NEK91.16631049
42RIPK11.15091718
43IKBKE1.13790044
44MAPKAPK31.07356902
45ERN11.05044418
46FES1.04942812
47ITK1.00305449
48PDK10.99478076
49TXK0.98003163
50EPHA30.97800727
51LYN0.95692693
52ILK0.95265058
53RPS6KB20.94575994
54SCYL20.92562413
55MAP3K80.91648118
56LRRK20.86460104
57HCK0.86358444
58DAPK10.85841639
59MATK0.81126569
60RPS6KA40.80393935
61ZAK0.79189658
62STK100.77924267
63ADRBK20.76764145
64ZAP700.76502920
65JAK20.76043308
66EIF2AK20.75939896
67PRKCE0.74703450
68PDPK10.73261919
69RPS6KA50.70528416
70DMPK0.69642173
71PKN10.68963182
72INSRR0.67735935
73CLK10.67107083
74PAK40.66871211
75MAP3K110.66641308
76PRKCQ0.64866362
77MST40.64688673
78RIPK40.63656115
79TNK20.63539988
80MAP3K30.62821433
81PTK60.61114803
82PRKCD0.60524473
83STK30.60280386
84PIM10.60259067
85RPS6KA60.60171403
86CHUK0.60082913
87BMPR20.60040695
88STK110.58547934
89STK40.57418106
90BTK0.56589342
91FGR0.56460754
92TTN0.54697624
93EGFR0.53572264
94CSNK1A1L0.53271148
95LCK0.51020961
96ABL10.50649621
97VRK10.49764755
98OBSCN0.49558261
99BMX0.49295682
100GRK60.47722505
101EIF2AK10.47599815
102MAP3K60.46253539
103CDK190.44955378
104PTK2B0.44386384
105PRKAA20.43369022
106CDK80.43314503
107DAPK20.42438859
108RPS6KC10.42272516
109RPS6KL10.42272516
110HIPK20.41437907
111SIK30.40908919
112BCKDK0.39440388
113MARK30.39228269
114PINK10.37714379
115MAP3K130.36917307
116TRIB30.36779553
117ABL20.36668731
118RPS6KA20.36659243
119MAPKAPK50.34912859
120PRKD10.34684576
121VRK20.34683345
122DAPK30.34180114
123ERBB20.31198193
124IGF1R0.31039031
125NME20.30988091
126GRK70.30937188
127PBK0.30353966
128ERBB30.30073956
129PKN20.29993859
130CAMK10.28854893
131CAMKK20.28178305
132MAP3K20.28107401
133MAPK110.28001987
134DYRK1B0.26980513
135CSNK1G30.26749822
136TAOK10.26715107
137SIK10.25146345
138STK38L0.24780530
139TGFBR10.23871276
140CSNK1G20.22990795
141MAPK40.21916696
142OXSR10.21545887
143MAPKAPK20.21530085
144CSNK2A10.20687896
145IRAK10.20649291
146MAPK130.20416614
147PRKCB0.20077196
148MAPK70.19482129

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053106.30723396
2Allograft rejection_Homo sapiens_hsa053305.48152741
3Autoimmune thyroid disease_Homo sapiens_hsa053205.18268429
4Fatty acid elongation_Homo sapiens_hsa000624.63183116
5Type I diabetes mellitus_Homo sapiens_hsa049404.50641028
6Primary bile acid biosynthesis_Homo sapiens_hsa001203.41434063
7Fatty acid metabolism_Homo sapiens_hsa012123.15211608
8Complement and coagulation cascades_Homo sapiens_hsa046102.75306475
9Staphylococcus aureus infection_Homo sapiens_hsa051502.52526528
10Pentose and glucuronate interconversions_Homo sapiens_hsa000402.42685094
11Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.40927701
12Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.09820064
13Toll-like receptor signaling pathway_Homo sapiens_hsa046202.09092718
14Lysosome_Homo sapiens_hsa041422.08998318
15Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.05939912
16Tryptophan metabolism_Homo sapiens_hsa003802.02696182
17Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.01234719
18Leishmaniasis_Homo sapiens_hsa051401.80939939
19Fatty acid degradation_Homo sapiens_hsa000711.79787960
20PPAR signaling pathway_Homo sapiens_hsa033201.76133632
21Arginine biosynthesis_Homo sapiens_hsa002201.60347553
22ABC transporters_Homo sapiens_hsa020101.58500546
23Systemic lupus erythematosus_Homo sapiens_hsa053221.49908973
24Chemokine signaling pathway_Homo sapiens_hsa040621.43806973
25Osteoclast differentiation_Homo sapiens_hsa043801.42430623
26Nitrogen metabolism_Homo sapiens_hsa009101.41378114
27Glycosaminoglycan degradation_Homo sapiens_hsa005311.40071836
28Viral myocarditis_Homo sapiens_hsa054161.32645588
29B cell receptor signaling pathway_Homo sapiens_hsa046621.32095393
30Drug metabolism - other enzymes_Homo sapiens_hsa009831.26334522
31Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.24872268
32Influenza A_Homo sapiens_hsa051641.22140851
33Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.21845001
34beta-Alanine metabolism_Homo sapiens_hsa004101.21792233
35Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.21762628
36Retinol metabolism_Homo sapiens_hsa008301.21588624
37Intestinal immune network for IgA production_Homo sapiens_hsa046721.20010143
38Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.19450595
39Peroxisome_Homo sapiens_hsa041461.17916276
40Vitamin digestion and absorption_Homo sapiens_hsa049771.17614296
41Histidine metabolism_Homo sapiens_hsa003401.16374254
42Starch and sucrose metabolism_Homo sapiens_hsa005001.15920412
43Toxoplasmosis_Homo sapiens_hsa051451.15723711
44Steroid hormone biosynthesis_Homo sapiens_hsa001401.13038193
45Regulation of autophagy_Homo sapiens_hsa041401.12659895
46Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.11395902
47Leukocyte transendothelial migration_Homo sapiens_hsa046701.11360925
48Tuberculosis_Homo sapiens_hsa051521.09716605
49Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.06952226
50Protein export_Homo sapiens_hsa030601.06854513
51Salmonella infection_Homo sapiens_hsa051321.05716381
52Herpes simplex infection_Homo sapiens_hsa051681.03044827
53Bile secretion_Homo sapiens_hsa049761.02666420
54NF-kappa B signaling pathway_Homo sapiens_hsa040641.01866731
55Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.01836243
56Antigen processing and presentation_Homo sapiens_hsa046121.00773129
57Pertussis_Homo sapiens_hsa051331.00158938
58Phagosome_Homo sapiens_hsa041450.97819112
59Shigellosis_Homo sapiens_hsa051310.95675336
60Platelet activation_Homo sapiens_hsa046110.95214350
61Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.95055213
62Ribosome_Homo sapiens_hsa030100.93322520
63Malaria_Homo sapiens_hsa051440.92102506
64Measles_Homo sapiens_hsa051620.89746233
65Propanoate metabolism_Homo sapiens_hsa006400.89590765
66Caffeine metabolism_Homo sapiens_hsa002320.88567421
67Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.87715965
68Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.86966942
69Hepatitis C_Homo sapiens_hsa051600.85894513
70Oxidative phosphorylation_Homo sapiens_hsa001900.85397711
71Chemical carcinogenesis_Homo sapiens_hsa052040.81963242
72Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.77098774
73Phenylalanine metabolism_Homo sapiens_hsa003600.73724633
74Regulation of actin cytoskeleton_Homo sapiens_hsa048100.73683580
75African trypanosomiasis_Homo sapiens_hsa051430.72183991
76TNF signaling pathway_Homo sapiens_hsa046680.71992169
77Primary immunodeficiency_Homo sapiens_hsa053400.71519110
78Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.71303773
79Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.71019902
80Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.69762598
81RNA polymerase_Homo sapiens_hsa030200.69246734
82Hematopoietic cell lineage_Homo sapiens_hsa046400.68586413
83Epstein-Barr virus infection_Homo sapiens_hsa051690.66091750
84Parkinsons disease_Homo sapiens_hsa050120.66045752
85Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.65164304
86Other glycan degradation_Homo sapiens_hsa005110.62080000
87Proteasome_Homo sapiens_hsa030500.56894371
88RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.56228606
89Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.56068438
90Apoptosis_Homo sapiens_hsa042100.55086238
91NOD-like receptor signaling pathway_Homo sapiens_hsa046210.52884516
92Legionellosis_Homo sapiens_hsa051340.51131097
93SNARE interactions in vesicular transport_Homo sapiens_hsa041300.51108718
94Notch signaling pathway_Homo sapiens_hsa043300.50693884
95Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.49941472
96Amoebiasis_Homo sapiens_hsa051460.49939706
97Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49664861
98Butanoate metabolism_Homo sapiens_hsa006500.48211011
99Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.47827338
100Focal adhesion_Homo sapiens_hsa045100.46988355
101Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.46271520
102Fat digestion and absorption_Homo sapiens_hsa049750.45663680
103Jak-STAT signaling pathway_Homo sapiens_hsa046300.45433323
104Adipocytokine signaling pathway_Homo sapiens_hsa049200.42346480
105Dilated cardiomyopathy_Homo sapiens_hsa054140.41353596
106Olfactory transduction_Homo sapiens_hsa047400.38928574
107Lysine degradation_Homo sapiens_hsa003100.38760631
108Adherens junction_Homo sapiens_hsa045200.38537848
109Insulin resistance_Homo sapiens_hsa049310.38127118
110Salivary secretion_Homo sapiens_hsa049700.37710668
111HTLV-I infection_Homo sapiens_hsa051660.37065399
112Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.36657621
113Collecting duct acid secretion_Homo sapiens_hsa049660.36585612
114Graft-versus-host disease_Homo sapiens_hsa053320.35823400
115Tyrosine metabolism_Homo sapiens_hsa003500.35818926
116Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.35569254
117Alzheimers disease_Homo sapiens_hsa050100.34598040
118Hepatitis B_Homo sapiens_hsa051610.33793554
119Rheumatoid arthritis_Homo sapiens_hsa053230.31119936
120Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.30224541
121Carbohydrate digestion and absorption_Homo sapiens_hsa049730.29407733
122Ovarian steroidogenesis_Homo sapiens_hsa049130.28663309
123Selenocompound metabolism_Homo sapiens_hsa004500.28250432
124Glycerolipid metabolism_Homo sapiens_hsa005610.26990119
125Huntingtons disease_Homo sapiens_hsa050160.25791666
126Acute myeloid leukemia_Homo sapiens_hsa052210.25642602
127alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.24212629
128Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.22195649
129Transcriptional misregulation in cancer_Homo sapiens_hsa052020.21858147
130Arachidonic acid metabolism_Homo sapiens_hsa005900.21650252
131Linoleic acid metabolism_Homo sapiens_hsa005910.20038119
132Phototransduction_Homo sapiens_hsa047440.18089600
133Cardiac muscle contraction_Homo sapiens_hsa042600.16003013
134Sulfur relay system_Homo sapiens_hsa041220.14657312
135Ether lipid metabolism_Homo sapiens_hsa005650.12302956
136Renin secretion_Homo sapiens_hsa049240.12045658
137Pyrimidine metabolism_Homo sapiens_hsa002400.09537651
138RNA degradation_Homo sapiens_hsa030180.08272203
139Taste transduction_Homo sapiens_hsa047420.05152399
140Serotonergic synapse_Homo sapiens_hsa047260.03940688
141Circadian entrainment_Homo sapiens_hsa047130.03055443
142Pancreatic secretion_Homo sapiens_hsa049720.00149347
143Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142-0.0756459
144Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750-0.0615895
145T cell receptor signaling pathway_Homo sapiens_hsa04660-0.0596712
146Morphine addiction_Homo sapiens_hsa05032-0.0194980
147Purine metabolism_Homo sapiens_hsa00230-0.0080117
148Calcium signaling pathway_Homo sapiens_hsa04020-0.0019047

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