CLECL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a type II transmembrane, C-type lectin-like protein that is highly expressed on dendritic and B cells. This protein may act as a T-cell costimulatory molecule that enhances interleukin-4 production, and maybe involved in the regulation of the immune response. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of B cell receptor signaling pathway (GO:0050855)6.32781478
2immunoglobulin mediated immune response (GO:0016064)5.77000638
3B cell receptor signaling pathway (GO:0050853)5.38970701
4CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)5.10330302
5positive regulation of gamma-delta T cell activation (GO:0046645)5.09534585
6B cell mediated immunity (GO:0019724)5.03395775
7positive thymic T cell selection (GO:0045059)4.88879947
8T cell migration (GO:0072678)4.81772718
9interferon-gamma-mediated signaling pathway (GO:0060333)4.71758404
10positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.59179614
11negative thymic T cell selection (GO:0045060)4.58494659
12negative T cell selection (GO:0043383)4.52155354
13regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.46206574
14positive regulation of B cell differentiation (GO:0045579)4.38364124
15antigen processing and presentation of endogenous antigen (GO:0019883)4.36051757
16cytidine metabolic process (GO:0046087)4.23417610
17cytidine catabolic process (GO:0006216)4.23417610
18cytidine deamination (GO:0009972)4.23417610
19positive T cell selection (GO:0043368)4.14353131
20modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.12568438
21modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.12568438
22positive regulation by organism of defense response of other organism involved in symbiotic interact4.12568438
23modulation by symbiont of host immune response (GO:0052553)4.12568438
24positive regulation by symbiont of host defense response (GO:0052509)4.12568438
25modulation by symbiont of host defense response (GO:0052031)4.12568438
26lymphocyte costimulation (GO:0031294)4.08359037
27B cell proliferation (GO:0042100)4.07533519
28regulation of B cell differentiation (GO:0045577)4.05979077
29T cell costimulation (GO:0031295)4.05677651
30NIK/NF-kappaB signaling (GO:0038061)4.03166888
31type I interferon signaling pathway (GO:0060337)4.02795552
32cellular response to type I interferon (GO:0071357)4.02795552
33thymic T cell selection (GO:0045061)4.02316227
34response to type I interferon (GO:0034340)3.99099900
35B cell homeostasis (GO:0001782)3.92418234
36positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.87734030
37pyrimidine ribonucleoside catabolic process (GO:0046133)3.85705047
38negative regulation of B cell proliferation (GO:0030889)3.85462899
39regulation of B cell proliferation (GO:0030888)3.83031608
40antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.79155834
41antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.73524810
42antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.73394717
43cellular response to interferon-gamma (GO:0071346)3.73124203
44regulation of alpha-beta T cell proliferation (GO:0046640)3.72086864
45regulation of antigen processing and presentation (GO:0002577)3.71074978
46defense response to protozoan (GO:0042832)3.69518429
47T cell selection (GO:0045058)3.65270892
48T cell lineage commitment (GO:0002360)3.63505556
49regulation of interferon-beta biosynthetic process (GO:0045357)3.62574761
50antigen receptor-mediated signaling pathway (GO:0050851)3.58851164
51positive regulation of B cell proliferation (GO:0030890)3.51417380
52regulation of gamma-delta T cell activation (GO:0046643)3.49891644
53T-helper 1 type immune response (GO:0042088)3.49696956
54regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.46818243
55macrophage activation involved in immune response (GO:0002281)3.45186694
56response to protozoan (GO:0001562)3.45027091
57regulation of interleukin-2 biosynthetic process (GO:0045076)3.44857112
58positive regulation of alpha-beta T cell proliferation (GO:0046641)3.43767939
59regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.40764650
60positive regulation of interferon-alpha production (GO:0032727)3.40602665
61regulation of dendritic cell antigen processing and presentation (GO:0002604)3.40223738
62myeloid dendritic cell activation (GO:0001773)3.31825023
63regulation of interferon-alpha production (GO:0032647)3.31723806
64positive regulation of antigen processing and presentation (GO:0002579)3.30629321
65negative regulation of cell killing (GO:0031342)3.27979300
66negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.27979300
67positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.25706500
68positive regulation of B cell activation (GO:0050871)3.25413850
69detection of bacterium (GO:0016045)3.24757119
70response to interferon-gamma (GO:0034341)3.21579167
71cellular response to interleukin-15 (GO:0071350)3.20137063
72regulation of B cell activation (GO:0050864)3.17945170
73adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli3.16569588
74myeloid dendritic cell differentiation (GO:0043011)3.13351666
75chaperone mediated protein folding requiring cofactor (GO:0051085)3.08015457
76negative regulation of viral genome replication (GO:0045071)3.06431820
77detection of other organism (GO:0098543)3.03452201
78response to interleukin-15 (GO:0070672)3.03385579
79regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.00113649
80positive regulation of humoral immune response (GO:0002922)2.98883972
81positive regulation of immunoglobulin mediated immune response (GO:0002891)2.97642561
82positive regulation of B cell mediated immunity (GO:0002714)2.97642561
83response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.97047238
84response to host immune response (GO:0052572)2.97047238
85production of molecular mediator of immune response (GO:0002440)2.96853567
86positive regulation of interleukin-2 production (GO:0032743)2.95833940
87positive regulation of type 2 immune response (GO:0002830)2.93941305
88T cell receptor signaling pathway (GO:0050852)2.93276055
89regulation of interferon-gamma biosynthetic process (GO:0045072)2.92967942
90DNA deamination (GO:0045006)2.92619981
91adaptive immune response (GO:0002250)2.92148576
92regulation of T-helper 1 cell differentiation (GO:0045625)2.89594110
93mast cell activation (GO:0045576)2.88099450
94regulation of gamma-delta T cell differentiation (GO:0045586)2.87281398
95positive regulation of defense response to virus by host (GO:0002230)2.86928140
96regulation of B cell apoptotic process (GO:0002902)2.84664696
97positive regulation of cytokine biosynthetic process (GO:0042108)2.80646373
98lymphocyte migration (GO:0072676)2.80157762
99Arp2/3 complex-mediated actin nucleation (GO:0034314)2.79909452
100regulation of T-helper cell differentiation (GO:0045622)2.79127491

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human7.30371041
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.60598162
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.49563471
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.33692438
5IRF8_21731497_ChIP-ChIP_J774_Mouse4.17542363
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.80190131
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.76984794
8SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.68016530
9MYC_22102868_ChIP-Seq_BL_Human3.39292919
10SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.97831308
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.96283409
12* MYB_26560356_Chip-Seq_TH2_Human2.92686845
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.92527219
14ELF1_17652178_ChIP-ChIP_JURKAT_Human2.76531710
15IRF8_27001747_Chip-Seq_BMDM_Mouse2.70880754
16STAT4_19710469_ChIP-ChIP_TH1__Mouse2.68473879
17SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.57892887
18STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.51041083
19CIITA_25753668_ChIP-Seq_RAJI_Human2.50100991
20* SPI1_23547873_ChIP-Seq_NB4_Human2.47337602
21MYB_26560356_Chip-Seq_TH1_Human2.44608383
22* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.35140058
23EGR1_19374776_ChIP-ChIP_THP-1_Human2.32121027
24MAF_26560356_Chip-Seq_TH1_Human2.24050283
25GATA1_22025678_ChIP-Seq_K562_Human2.13249995
26* RUNX_20019798_ChIP-Seq_JUKART_Human2.12802381
27SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.11228054
28NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.07082921
29VDR_21846776_ChIP-Seq_THP-1_Human1.97048015
30MYB_21317192_ChIP-Seq_ERMYB_Mouse1.96645199
31SCL_19346495_ChIP-Seq_HPC-7_Human1.89063982
32FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.88574270
33GATA3_27048872_Chip-Seq_THYMUS_Human1.85267381
34RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.80089809
35VDR_24763502_ChIP-Seq_THP-1_Human1.75678291
36FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.75409163
37NOTCH1_21737748_ChIP-Seq_TLL_Human1.74074689
38UTX_26944678_Chip-Seq_JUKART_Human1.72451497
39BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.70654346
40* GATA3_26560356_Chip-Seq_TH2_Human1.68890010
41VDR_23849224_ChIP-Seq_CD4+_Human1.67904244
42E2F4_17652178_ChIP-ChIP_JURKAT_Human1.67519626
43NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.63470512
44VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.62433973
45RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.59702933
46MAF_26560356_Chip-Seq_TH2_Human1.58676667
47ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.55934360
48* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.55784222
49BRD4_27068464_Chip-Seq_AML-cells_Mouse1.50820513
50RUNX1_22412390_ChIP-Seq_EML_Mouse1.45711177
51TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.43836937
52FOXP3_21729870_ChIP-Seq_TREG_Human1.35594799
53SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.34400312
54SPI1_23127762_ChIP-Seq_K562_Human1.31931141
55HOXB4_20404135_ChIP-ChIP_EML_Mouse1.31300926
56GATA2_22383799_ChIP-Seq_G1ME_Mouse1.24651293
57CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.22116682
58EST1_17652178_ChIP-ChIP_JURKAT_Human1.21328345
59MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.20388422
60ERG_20887958_ChIP-Seq_HPC-7_Mouse1.13804972
61E2F7_22180533_ChIP-Seq_HELA_Human1.12759707
62NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.12105984
63VDR_24787735_ChIP-Seq_THP-1_Human1.09384013
64LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.07873603
65LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.07527024
66PU.1_20513432_ChIP-Seq_Bcells_Mouse1.06965195
67GABP_17652178_ChIP-ChIP_JURKAT_Human1.03693102
68VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.03421466
69TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98568848
70KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.98392607
71PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98130987
72PU_27001747_Chip-Seq_BMDM_Mouse0.97811729
73Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.95277748
74EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.94708289
75RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.94233372
76CREB1_15753290_ChIP-ChIP_HEK293T_Human0.92279647
77SMRT_27268052_Chip-Seq_Bcells_Human0.89444757
78TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.89430152
79CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88813628
80GATA1_22383799_ChIP-Seq_G1ME_Mouse0.88158329
81PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88041792
82TCF7_22412390_ChIP-Seq_EML_Mouse0.87748750
83TFEB_21752829_ChIP-Seq_HELA_Human0.86955297
84GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.86342970
85IKZF1_21737484_ChIP-ChIP_HCT116_Human0.85976252
86KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.85569593
87E2F1_21310950_ChIP-Seq_MCF-7_Human0.85213619
88IRF1_19129219_ChIP-ChIP_H3396_Human0.84825953
89FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84378972
90NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.83695211
91SMAD_19615063_ChIP-ChIP_OVARY_Human0.83411460
92MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.81930823
93* GATA3_26560356_Chip-Seq_TH1_Human0.81838692
94CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.81837716
95PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.79204042
96EGR1_23403033_ChIP-Seq_LIVER_Mouse0.76822391
97GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.76590472
98SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.76546759
99SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.75895339
100BCL6_27268052_Chip-Seq_Bcells_Human0.74000856

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation5.50522218
2MP0005671_abnormal_response_to4.50373257
3MP0001800_abnormal_humoral_immune3.99325978
4MP0000685_abnormal_immune_system3.88939214
5MP0005387_immune_system_phenotype3.75788433
6MP0001790_abnormal_immune_system3.75788433
7MP0005000_abnormal_immune_tolerance3.39843432
8MP0002452_abnormal_antigen_presenting3.12529763
9MP0002723_abnormal_immune_serum3.01760948
10MP0003303_peritoneal_inflammation3.00844174
11MP0003763_abnormal_thymus_physiology3.00357590
12MP0002166_altered_tumor_susceptibility2.89072485
13MP0002420_abnormal_adaptive_immunity2.76600458
14MP0009785_altered_susceptibility_to2.76518419
15MP0001819_abnormal_immune_cell2.74583322
16MP0002148_abnormal_hypersensitivity_rea2.67986201
17MP0002138_abnormal_hepatobiliary_system2.56908312
18MP0005025_abnormal_response_to2.50230510
19MP0002398_abnormal_bone_marrow2.43014618
20MP0003436_decreased_susceptibility_to2.36418663
21MP0000716_abnormal_immune_system2.27557447
22MP0002419_abnormal_innate_immunity2.17763449
23MP0002006_tumorigenesis2.08428832
24MP0005310_abnormal_salivary_gland2.07317574
25MP0001348_abnormal_lacrimal_gland2.07173034
26MP0000689_abnormal_spleen_morphology2.02251135
27MP0009333_abnormal_splenocyte_physiolog1.96308312
28MP0001873_stomach_inflammation1.95805932
29MP0010155_abnormal_intestine_physiology1.95703725
30MP0002429_abnormal_blood_cell1.87160589
31MP0006082_CNS_inflammation1.85771130
32MP0002405_respiratory_system_inflammati1.83002833
33MP0001845_abnormal_inflammatory_respons1.80527238
34MP0002722_abnormal_immune_system1.78741913
35MP0005451_abnormal_body_composition1.65938362
36MP0005464_abnormal_platelet_physiology1.53914189
37MP0000703_abnormal_thymus_morphology1.51483146
38MP0003300_gastrointestinal_ulcer1.49024793
39MP0001853_heart_inflammation1.48428709
40MP0002163_abnormal_gland_morphology1.47415279
41MP0003724_increased_susceptibility_to1.44371045
42MP0008057_abnormal_DNA_replication1.43068049
43MP0002396_abnormal_hematopoietic_system1.41412457
44MP0004947_skin_inflammation1.33958762
45MP0003806_abnormal_nucleotide_metabolis1.31685898
46MP0003183_abnormal_peptide_metabolism1.29021353
47MP0003866_abnormal_defecation1.27761296
48MP0008469_abnormal_protein_level1.25020362
49MP0003045_fibrosis1.22548122
50MP0005645_abnormal_hypothalamus_physiol1.17103028
51MP0002019_abnormal_tumor_incidence1.06529749
52MP0000372_irregular_coat_pigmentation1.05476123
53MP0004808_abnormal_hematopoietic_stem1.03718386
54MP0002009_preneoplasia1.02924353
55MP0010094_abnormal_chromosome_stability1.01388770
56MP0009764_decreased_sensitivity_to1.01155624
57MP0005075_abnormal_melanosome_morpholog1.00619289
58MP0002139_abnormal_hepatobiliary_system0.94042119
59MP0005379_endocrine/exocrine_gland_phen0.89875241
60MP0000858_altered_metastatic_potential0.83989759
61MP0003172_abnormal_lysosome_physiology0.83388086
62MP0001533_abnormal_skeleton_physiology0.83274276
63MP0001545_abnormal_hematopoietic_system0.82937253
64MP0005397_hematopoietic_system_phenotyp0.82937253
65MP0009763_increased_sensitivity_to0.80326514
66MP0004381_abnormal_hair_follicle0.78880528
67MP0003077_abnormal_cell_cycle0.77825973
68MP0000490_abnormal_crypts_of0.76045862
69MP0002933_joint_inflammation0.74895299
70MP0005166_decreased_susceptibility_to0.74643586
71MP0003693_abnormal_embryo_hatching0.71133905
72MP0001663_abnormal_digestive_system0.71045371
73MP0000015_abnormal_ear_pigmentation0.70943547
74MP0003252_abnormal_bile_duct0.69431143
75MP0002693_abnormal_pancreas_physiology0.68576422
76MP0000465_gastrointestinal_hemorrhage0.67091498
77MP0000371_diluted_coat_color0.65652439
78MP0002928_abnormal_bile_duct0.64529807
79MP0003448_altered_tumor_morphology0.62913253
80MP0000343_altered_response_to0.61939843
81MP0002998_abnormal_bone_remodeling0.61792300
82MP0002136_abnormal_kidney_physiology0.61176210
83MP0000313_abnormal_cell_death0.59000355
84MP0003075_altered_response_to0.58428660
85MP0000609_abnormal_liver_physiology0.57429516
86MP0010307_abnormal_tumor_latency0.56030301
87MP0009765_abnormal_xenobiotic_induced0.55572333
88MP0009278_abnormal_bone_marrow0.54060473
89MP0008007_abnormal_cellular_replicative0.53792531
90MP0003786_premature_aging0.53656578
91MP0003111_abnormal_nucleus_morphology0.51820045
92MP0005058_abnormal_lysosome_morphology0.51706134
93MP0003091_abnormal_cell_migration0.51350692
94MP0000249_abnormal_blood_vessel0.50547495
95MP0008874_decreased_physiological_sensi0.49035292
96MP0004510_myositis0.49001955
97MP0006036_abnormal_mitochondrial_physio0.46401777
98MP0008872_abnormal_physiological_respon0.46196388
99MP0000604_amyloidosis0.45855248
100MP0001191_abnormal_skin_condition0.42826073

Predicted human phenotypes

RankGene SetZ-score
1Agammaglobulinemia (HP:0004432)6.79462352
2Gastrointestinal stroma tumor (HP:0100723)5.45380408
3Meningitis (HP:0001287)5.23800938
4Recurrent bronchitis (HP:0002837)4.88418185
5Recurrent viral infections (HP:0004429)4.77997098
6Recurrent sinusitis (HP:0011108)4.77982900
7IgA deficiency (HP:0002720)4.74031925
8Vasculitis (HP:0002633)4.57052361
9Mediastinal lymphadenopathy (HP:0100721)4.41611455
10IgG deficiency (HP:0004315)4.34698252
11Recurrent cutaneous fungal infections (HP:0011370)4.25210943
12Chronic mucocutaneous candidiasis (HP:0002728)4.25210943
13Abnormal delayed hypersensitivity skin test (HP:0002963)4.24337675
14Panhypogammaglobulinemia (HP:0003139)4.16840161
15Lymphopenia (HP:0001888)4.05455746
16Recurrent fungal infections (HP:0002841)4.02393715
17Abnormality of cells of the lymphoid lineage (HP:0012140)3.96117797
18IgM deficiency (HP:0002850)3.95547489
19Abnormality of the prostate (HP:0008775)3.92282458
20Recurrent bacterial skin infections (HP:0005406)3.87103988
21Cellulitis (HP:0100658)3.79807950
22Obstructive lung disease (HP:0006536)3.76498033
23Chronic obstructive pulmonary disease (HP:0006510)3.76498033
24Increased IgM level (HP:0003496)3.76256201
25Colitis (HP:0002583)3.74191547
26Recurrent abscess formation (HP:0002722)3.64251697
27Papilloma (HP:0012740)3.60671530
28Verrucae (HP:0200043)3.60671530
29Abnormality of T cell number (HP:0011839)3.60632562
30Pulmonary infiltrates (HP:0002113)3.60205598
31Abnormality of T cells (HP:0002843)3.51497803
32Abnormality of T cell physiology (HP:0011840)3.43521243
33Abnormality of B cell number (HP:0010975)3.43403660
34B lymphocytopenia (HP:0010976)3.39230047
35Restrictive lung disease (HP:0002091)3.37121027
36T lymphocytopenia (HP:0005403)3.34459896
37Chronic diarrhea (HP:0002028)3.34035590
38Autoimmune hemolytic anemia (HP:0001890)3.33545078
39Emphysema (HP:0002097)3.28948753
40Eczematoid dermatitis (HP:0000976)3.28011469
41Hemoptysis (HP:0002105)3.27616721
42Recurrent skin infections (HP:0001581)3.22264646
43Recurrent pneumonia (HP:0006532)3.21154208
44Gastrointestinal infarctions (HP:0005244)3.20851304
45Osteomyelitis (HP:0002754)3.09913104
46Recurrent lower respiratory tract infections (HP:0002783)3.02907894
47Inflammation of the large intestine (HP:0002037)3.00502443
48Skin rash (HP:0000988)2.98449376
49Abnormality of macrophages (HP:0004311)2.96212578
50Stomatitis (HP:0010280)2.93711528
51Lymphoma (HP:0002665)2.93086267
52Urticaria (HP:0001025)2.89516386
53Encephalitis (HP:0002383)2.89494791
54Gastrointestinal inflammation (HP:0004386)2.85672638
55Autoimmune thrombocytopenia (HP:0001973)2.78530945
56Chest pain (HP:0100749)2.75939681
57Bronchitis (HP:0012387)2.71558762
58Chronic otitis media (HP:0000389)2.68769999
59Elevated erythrocyte sedimentation rate (HP:0003565)2.67901396
60Abnormality of the pleura (HP:0002103)2.65874492
61Pulmonary fibrosis (HP:0002206)2.62404471
62Fatigue (HP:0012378)2.60002788
63Chronic sinusitis (HP:0011109)2.59843357
64Abnormality of male internal genitalia (HP:0000022)2.51305277
65Granulocytopenia (HP:0001913)2.46177603
66Retrobulbar optic neuritis (HP:0100654)2.44503226
67Optic neuritis (HP:0100653)2.44503226
68Eosinophilia (HP:0001880)2.44077028
69Recurrent gram-negative bacterial infections (HP:0005420)2.43759742
70Sepsis (HP:0100806)2.42450123
71Acrocyanosis (HP:0001063)2.42170032
72Viral hepatitis (HP:0006562)2.32252892
73Gangrene (HP:0100758)2.28242039
74Amaurosis fugax (HP:0100576)2.27013322
75Recurrent otitis media (HP:0000403)2.26266433
76Arterial thrombosis (HP:0004420)2.24617417
77Hypergammaglobulinemia (HP:0010702)2.24548495
78Spontaneous hematomas (HP:0007420)2.23168961
79Skin ulcer (HP:0200042)2.22466790
80Hypertensive crisis (HP:0100735)2.21521455
81Arthralgia (HP:0002829)2.20147250
82Severe combined immunodeficiency (HP:0004430)2.19789355
83Basal cell carcinoma (HP:0002671)2.19125386
84Abnormality of eosinophils (HP:0001879)2.17419369
85Ureteral stenosis (HP:0000071)2.17325828
86Pulmonary embolism (HP:0002204)2.15956042
87Leukopenia (HP:0001882)2.15621014
88Joint swelling (HP:0001386)2.11679764
89Ureteral obstruction (HP:0006000)2.09334147
90Neutropenia (HP:0001875)2.08434537
91Xerostomia (HP:0000217)2.07717796
92Combined immunodeficiency (HP:0005387)2.07293689
93Increased IgE level (HP:0003212)2.07257975
94Squamous cell carcinoma (HP:0002860)2.02792321
95Leukocytosis (HP:0001974)2.02487641
96Myositis (HP:0100614)2.02146008
97Acute hepatic failure (HP:0006554)2.01896981
98Orchitis (HP:0100796)1.95273222
99Polyneuropathy (HP:0001271)1.93750321
100Mucosal telangiectasiae (HP:0100579)1.91878546

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.79838542
2RIPK44.74641750
3EIF2AK33.30883103
4BLK3.24678126
5MAP3K142.75969858
6SYK2.75634580
7IRAK42.59855665
8BMPR22.42706916
9MAP3K132.31574134
10TYK22.25767033
11PRPF4B2.23855485
12BTK2.20950929
13IKBKE2.18583496
14TLK12.18257890
15CSF1R2.07629160
16TXK1.96532376
17IKBKB1.96299488
18KIT1.94500205
19TEC1.81355456
20ITK1.80493809
21LYN1.70937007
22TBK11.68195236
23JAK31.65147984
24JAK11.64206691
25MST41.60592235
26MATK1.55042500
27NEK91.36120575
28TAOK31.34455264
29PASK1.33340576
30NME21.30869691
31SMG11.29592825
32CSK1.29324811
33MAP3K101.26052954
34PRKCQ1.20166367
35MAPK111.17863060
36FES1.16403319
37VRK11.15411388
38HCK1.13086814
39LCK1.12774435
40STK241.09071427
41ZAK1.01778532
42CCNB10.98657131
43TESK20.97861983
44PIM10.95965720
45SIK30.93645026
46CAMKK20.92747645
47CHUK0.92432284
48PIK3CG0.91864095
49FGFR40.89651181
50FGFR30.86672612
51SIK20.86571972
52CDK40.86160685
53STK100.83893618
54JAK20.77183002
55MARK30.71642235
56ERN10.71606629
57MAPK120.71396725
58KDR0.71177817
59GRK60.67711369
60RPS6KA50.66057635
61CDK190.64594055
62PDK10.62097753
63MAPK70.61927533
64BRD40.61183509
65STK40.60234409
66EIF2AK20.59902031
67EIF2AK10.59244502
68EEF2K0.58866607
69CDK120.58588130
70FRK0.58544914
71CAMKK10.56400497
72STK160.54446654
73FGR0.52481604
74DAPK30.51990546
75IRAK10.50792771
76RPS6KB20.48056386
77MAP3K80.44630139
78MELK0.44402333
79TNK20.43895100
80ABL10.43139859
81MAPKAPK20.38922280
82PRKCD0.36194179
83TAF10.34087165
84ZAP700.33995381
85MAPK40.33801067
86TAOK20.31924171
87ALK0.31655146
88TRPM70.31171413
89HIPK20.30332951
90MAPKAPK30.28897357
91VRK20.28838544
92PKN10.26477736
93CDC42BPA0.26406058
94ATR0.25550217
95PRKCH0.24372804
96PLK40.22067760
97FYN0.21679855
98NUAK10.21035367
99IRAK20.20948952
100EGFR0.20931748

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053305.15977600
2Asthma_Homo sapiens_hsa053105.03980456
3Autoimmune thyroid disease_Homo sapiens_hsa053204.88919028
4Intestinal immune network for IgA production_Homo sapiens_hsa046724.87583992
5Graft-versus-host disease_Homo sapiens_hsa053324.35019328
6Type I diabetes mellitus_Homo sapiens_hsa049403.72823174
7Primary immunodeficiency_Homo sapiens_hsa053403.43246975
8Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.11109789
9Antigen processing and presentation_Homo sapiens_hsa046122.79371209
10Viral myocarditis_Homo sapiens_hsa054162.74669650
11Leishmaniasis_Homo sapiens_hsa051402.69051564
12Staphylococcus aureus infection_Homo sapiens_hsa051502.51950879
13B cell receptor signaling pathway_Homo sapiens_hsa046622.23628525
14Systemic lupus erythematosus_Homo sapiens_hsa053222.21829020
15Rheumatoid arthritis_Homo sapiens_hsa053231.85250136
16NF-kappa B signaling pathway_Homo sapiens_hsa040641.77927884
17Herpes simplex infection_Homo sapiens_hsa051681.74399019
18Influenza A_Homo sapiens_hsa051641.65701800
19Hematopoietic cell lineage_Homo sapiens_hsa046401.58877649
20Toxoplasmosis_Homo sapiens_hsa051451.51741735
21Measles_Homo sapiens_hsa051621.51479380
22Tuberculosis_Homo sapiens_hsa051521.47039059
23Toll-like receptor signaling pathway_Homo sapiens_hsa046201.43519188
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.22911884
25T cell receptor signaling pathway_Homo sapiens_hsa046601.22213752
26Osteoclast differentiation_Homo sapiens_hsa043801.21430909
27Epstein-Barr virus infection_Homo sapiens_hsa051691.20080225
28Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.10095176
29RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.04802302
30Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.93581939
31Phagosome_Homo sapiens_hsa041450.86572602
32Proteasome_Homo sapiens_hsa030500.84417965
33Jak-STAT signaling pathway_Homo sapiens_hsa046300.80979924
34Viral carcinogenesis_Homo sapiens_hsa052030.78440187
35HTLV-I infection_Homo sapiens_hsa051660.76705469
36Hepatitis B_Homo sapiens_hsa051610.75952719
37Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.75401978
38Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.75147898
39Apoptosis_Homo sapiens_hsa042100.72581133
40NOD-like receptor signaling pathway_Homo sapiens_hsa046210.70736999
41Chemokine signaling pathway_Homo sapiens_hsa040620.70492858
42TNF signaling pathway_Homo sapiens_hsa046680.68184677
43Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.64960393
44Alcoholism_Homo sapiens_hsa050340.55854186
45Legionellosis_Homo sapiens_hsa051340.54867911
46Transcriptional misregulation in cancer_Homo sapiens_hsa052020.52743764
47Shigellosis_Homo sapiens_hsa051310.50490601
48African trypanosomiasis_Homo sapiens_hsa051430.48805204
49Hepatitis C_Homo sapiens_hsa051600.48067634
50Protein export_Homo sapiens_hsa030600.43257702
51Ribosome_Homo sapiens_hsa030100.39541118
52Non-homologous end-joining_Homo sapiens_hsa034500.38958081
53Acute myeloid leukemia_Homo sapiens_hsa052210.36628997
54Homologous recombination_Homo sapiens_hsa034400.36230687
55RNA degradation_Homo sapiens_hsa030180.34266570
56Malaria_Homo sapiens_hsa051440.33445477
57DNA replication_Homo sapiens_hsa030300.33114664
58Platelet activation_Homo sapiens_hsa046110.30004508
59Pertussis_Homo sapiens_hsa051330.29532409
60p53 signaling pathway_Homo sapiens_hsa041150.28300486
61Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.27922523
62Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.27433918
63Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.26004351
64Salmonella infection_Homo sapiens_hsa051320.24037991
65Spliceosome_Homo sapiens_hsa030400.23847197
66Other glycan degradation_Homo sapiens_hsa005110.22323509
67Non-small cell lung cancer_Homo sapiens_hsa052230.20548858
68Neurotrophin signaling pathway_Homo sapiens_hsa047220.19988294
69SNARE interactions in vesicular transport_Homo sapiens_hsa041300.19413338
70Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.19323035
71Nucleotide excision repair_Homo sapiens_hsa034200.15137677
72Mismatch repair_Homo sapiens_hsa034300.14993559
73Leukocyte transendothelial migration_Homo sapiens_hsa046700.13885572
74Pancreatic cancer_Homo sapiens_hsa052120.12824148
75Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.10596831
76Sphingolipid signaling pathway_Homo sapiens_hsa040710.09730166
77Prolactin signaling pathway_Homo sapiens_hsa049170.09208592
78Carbohydrate digestion and absorption_Homo sapiens_hsa049730.08631914
79Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.07740908
80Lysosome_Homo sapiens_hsa041420.07347054
81Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.04324033
82HIF-1 signaling pathway_Homo sapiens_hsa040660.04081637
83Chronic myeloid leukemia_Homo sapiens_hsa052200.03592117
84Fanconi anemia pathway_Homo sapiens_hsa034600.03446900
85Renal cell carcinoma_Homo sapiens_hsa052110.03229240
86MAPK signaling pathway_Homo sapiens_hsa040100.02191989
87AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.01612819
88Prostate cancer_Homo sapiens_hsa05215-0.0765765
89Bacterial invasion of epithelial cells_Homo sapiens_hsa05100-0.0764183
90Endocytosis_Homo sapiens_hsa04144-0.0731957
91RNA polymerase_Homo sapiens_hsa03020-0.0624350
92RNA transport_Homo sapiens_hsa03013-0.0597057
93FoxO signaling pathway_Homo sapiens_hsa04068-0.0490147
94Pyrimidine metabolism_Homo sapiens_hsa00240-0.0423162
95Pentose phosphate pathway_Homo sapiens_hsa00030-0.0411430
96VEGF signaling pathway_Homo sapiens_hsa04370-0.0346560
97Small cell lung cancer_Homo sapiens_hsa05222-0.0310457
98One carbon pool by folate_Homo sapiens_hsa00670-0.0247588
99Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120-0.0185077
100Base excision repair_Homo sapiens_hsa03410-0.0135614

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