CLGN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Calmegin is a testis-specific endoplasmic reticulum chaperone protein. CLGN may play a role in spermatogeneisis and infertility. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement (GO:0003351)9.66150557
2multicellular organism reproduction (GO:0032504)9.57178727
3acrosome reaction (GO:0007340)9.55331486
4acrosome assembly (GO:0001675)9.31972745
5cilium movement (GO:0003341)8.76248673
6* sperm-egg recognition (GO:0035036)8.72914533
7plasma membrane fusion (GO:0045026)8.71801184
8epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.59177310
9male meiosis (GO:0007140)8.56516286
10regulation of cilium movement (GO:0003352)7.91806907
11spermatid development (GO:0007286)7.89985299
12motile cilium assembly (GO:0044458)7.85984285
13reproduction (GO:0000003)7.80314361
14* cell-cell recognition (GO:0009988)7.75126069
15synaptonemal complex organization (GO:0070193)7.72222871
16* binding of sperm to zona pellucida (GO:0007339)7.70863511
17synaptonemal complex assembly (GO:0007130)7.33528194
18cell wall macromolecule metabolic process (GO:0044036)7.11496623
19cell wall macromolecule catabolic process (GO:0016998)7.11496623
20sperm capacitation (GO:0048240)6.73911184
21DNA methylation involved in gamete generation (GO:0043046)6.45405816
22* single fertilization (GO:0007338)6.25651569
23negative regulation of inclusion body assembly (GO:0090084)5.95986259
24male meiosis I (GO:0007141)5.83880257
25protein localization to cilium (GO:0061512)5.75463062
26* fertilization (GO:0009566)5.58501035
27ventricular system development (GO:0021591)5.49864951
28regulation of microtubule-based movement (GO:0060632)5.14920903
29chromosome organization involved in meiosis (GO:0070192)5.03999369
30spermatogenesis (GO:0007283)5.02461545
31male gamete generation (GO:0048232)5.00563196
32protein polyglutamylation (GO:0018095)4.99763210
33meiotic nuclear division (GO:0007126)4.85497428
34calcium ion-dependent exocytosis (GO:0017156)4.84597074
35microtubule severing (GO:0051013)4.80416669
36germ cell development (GO:0007281)4.74611799
37meiosis I (GO:0007127)4.68095762
38cellular process involved in reproduction in multicellular organism (GO:0022412)4.65362565
39gamete generation (GO:0007276)4.63200809
40regulation of inclusion body assembly (GO:0090083)4.57828430
41meiotic cell cycle (GO:0051321)4.38288922
42intraciliary transport (GO:0042073)4.36777316
43microtubule depolymerization (GO:0007019)4.26975178
44axoneme assembly (GO:0035082)4.15718851
45left/right pattern formation (GO:0060972)4.12305741
46negative regulation of organelle assembly (GO:1902116)4.10739611
47* cell recognition (GO:0008037)4.07998657
48microtubule-based movement (GO:0007018)3.99830037
49seminiferous tubule development (GO:0072520)3.91339663
50regulation of meiosis I (GO:0060631)3.84143235
51organic cation transport (GO:0015695)3.79040974
52spermatid nucleus differentiation (GO:0007289)3.69668647
53multicellular organismal reproductive process (GO:0048609)3.61801336
54cilium morphogenesis (GO:0060271)3.53077096
55gene silencing by RNA (GO:0031047)3.52147372
56genitalia morphogenesis (GO:0035112)3.42239051
57monoubiquitinated protein deubiquitination (GO:0035520)3.41190650
58mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.32538296
59cilium organization (GO:0044782)3.22874260
60detection of calcium ion (GO:0005513)3.22746596
61heart process (GO:0003015)3.17338386
62heart contraction (GO:0060047)3.17338386
63protein complex biogenesis (GO:0070271)3.17311763
64cilium assembly (GO:0042384)3.11730901
65lactate metabolic process (GO:0006089)3.03521252
66regulation of centriole replication (GO:0046599)3.02725475
67cellular component assembly involved in morphogenesis (GO:0010927)3.00153266
68microtubule polymerization or depolymerization (GO:0031109)3.00054272
69microtubule bundle formation (GO:0001578)2.98732057
70mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.97802006
71mitochondrial respiratory chain complex assembly (GO:0033108)2.97753894
72protein refolding (GO:0042026)2.97665681
73meiotic cell cycle process (GO:1903046)2.97311298
74centriole replication (GO:0007099)2.93339481
75organelle disassembly (GO:1903008)2.92083488
76regulation of hexokinase activity (GO:1903299)2.90898601
77regulation of glucokinase activity (GO:0033131)2.90898601
78synapsis (GO:0007129)2.90675060
79multicellular organismal development (GO:0007275)2.88864845
80response to methylmercury (GO:0051597)2.88281622
81ribonucleoprotein complex disassembly (GO:0032988)2.87882257
82water-soluble vitamin biosynthetic process (GO:0042364)2.87284233
83peptidyl-glutamic acid modification (GO:0018200)2.86021240
84chaperone-mediated protein complex assembly (GO:0051131)2.85037544
85nucleoside diphosphate phosphorylation (GO:0006165)2.82728315
86response to redox state (GO:0051775)2.82527041
87regulation of protein polyubiquitination (GO:1902914)2.82472797
88alditol metabolic process (GO:0019400)2.81858249
89mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.79468708
90mitochondrial respiratory chain complex I assembly (GO:0032981)2.79468708
91NADH dehydrogenase complex assembly (GO:0010257)2.79468708
92glycerol ether metabolic process (GO:0006662)2.77571298
93energy coupled proton transport, down electrochemical gradient (GO:0015985)2.77421324
94ATP synthesis coupled proton transport (GO:0015986)2.77421324
95central nervous system myelination (GO:0022010)2.76039923
96axon ensheathment in central nervous system (GO:0032291)2.76039923
97regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.74996503
98membrane depolarization during action potential (GO:0086010)2.71629950
99glycerol metabolic process (GO:0006071)2.70153611
100establishment of protein localization to mitochondrial membrane (GO:0090151)2.69237375
101thalamus development (GO:0021794)2.68577031
102pyrimidine nucleobase catabolic process (GO:0006208)2.64383412
103positive regulation of mitochondrial fission (GO:0090141)2.62514436
104polyol catabolic process (GO:0046174)2.62487973
105sex differentiation (GO:0007548)2.62449386
106nonmotile primary cilium assembly (GO:0035058)2.60306749
107carnitine transmembrane transport (GO:1902603)2.58462223
108protein K11-linked deubiquitination (GO:0035871)2.57672925
109cellular ketone body metabolic process (GO:0046950)2.57170398
110somite rostral/caudal axis specification (GO:0032525)2.57068902
111centriole assembly (GO:0098534)2.57036137
112ether metabolic process (GO:0018904)2.56104681
113amino-acid betaine transport (GO:0015838)2.55921310
114carnitine transport (GO:0015879)2.55921310
115respiratory electron transport chain (GO:0022904)2.54410497
116regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.54078154
117chromatin remodeling at centromere (GO:0031055)2.53690183
118positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.53103285
119respiratory chain complex IV assembly (GO:0008535)2.52541493
120CENP-A containing nucleosome assembly (GO:0034080)2.51179385
121electron transport chain (GO:0022900)2.49578613
122microtubule-based process (GO:0007017)2.46851103
123sarcomere organization (GO:0045214)2.46583055
124regulation of mitochondrial translation (GO:0070129)2.45331928
125regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.41145575
126aspartate family amino acid catabolic process (GO:0009068)2.40070543
127fatty acid elongation (GO:0030497)2.39988893
128cardiac myofibril assembly (GO:0055003)2.39222657
129regulation of spindle checkpoint (GO:0090231)2.38870125
130protein neddylation (GO:0045116)2.38001023
131negative regulation of skeletal muscle tissue development (GO:0048642)2.37881434
132protein K6-linked ubiquitination (GO:0085020)2.36413659
133muscle filament sliding (GO:0030049)2.36362571
134actin-myosin filament sliding (GO:0033275)2.36362571
135branched-chain amino acid catabolic process (GO:0009083)2.36224816
136left/right axis specification (GO:0070986)2.36187224
137positive regulation of ATP catabolic process (GO:1903291)2.35896616
138positive regulation of ATPase activity (GO:0032781)2.35896616
139regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.35673638
140cytochrome complex assembly (GO:0017004)2.35261424
141lysine metabolic process (GO:0006553)2.34610730
142lysine catabolic process (GO:0006554)2.34610730
143retinal ganglion cell axon guidance (GO:0031290)2.34294647
144cullin deneddylation (GO:0010388)2.33591571
145gene silencing (GO:0016458)2.30828036
146nucleobase catabolic process (GO:0046113)2.29816035
147regulation of chromatin binding (GO:0035561)2.29697697
148negative regulation of hormone biosynthetic process (GO:0032353)2.29469675
149ketone body metabolic process (GO:1902224)2.25913566
150DNA damage response, detection of DNA damage (GO:0042769)2.23412564
151regulation of type B pancreatic cell apoptotic process (GO:2000674)2.22557264
152ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.21195652
153regulation of cell communication by electrical coupling (GO:0010649)2.18775960
154DNA double-strand break processing (GO:0000729)2.17238800
155L-serine metabolic process (GO:0006563)2.17080742
156presynaptic membrane assembly (GO:0097105)2.16910953
157presynaptic membrane organization (GO:0097090)2.16310700
158actin-mediated cell contraction (GO:0070252)2.15900791
159regulation of acyl-CoA biosynthetic process (GO:0050812)2.15681208
160protein deneddylation (GO:0000338)2.14139572
161chaperone-mediated protein transport (GO:0072321)2.13408756
162peroxisome fission (GO:0016559)2.12368720
163regulation of coenzyme metabolic process (GO:0051196)2.11093309
164regulation of cofactor metabolic process (GO:0051193)2.11093309
165negative regulation of cytosolic calcium ion concentration (GO:0051481)2.10927040
166short-term memory (GO:0007614)2.10107233
167C-terminal protein amino acid modification (GO:0018410)2.07764878
168oxidative phosphorylation (GO:0006119)2.07614043
169cardiac muscle contraction (GO:0060048)2.07259727
170cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.05585280
171negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.04811681
172C-terminal protein lipidation (GO:0006501)2.04741088
173histone exchange (GO:0043486)2.04732022
174neuron fate determination (GO:0048664)2.04322222
175regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.03522050
176regulation of actin filament-based movement (GO:1903115)2.03268673
177myofibril assembly (GO:0030239)2.02931159
178cholesterol biosynthetic process (GO:0006695)2.02403049
179lipid particle organization (GO:0034389)2.01751735
180regulation of membrane repolarization (GO:0060306)2.01112973
181regulation of action potential (GO:0098900)2.01083156
182regulation of ATP catabolic process (GO:1903289)2.01074834
183regulation of ATPase activity (GO:0043462)2.01074834
184smoothened signaling pathway (GO:0007224)2.01030126
185preassembly of GPI anchor in ER membrane (GO:0016254)2.00960732
186cilium or flagellum-dependent cell motility (GO:0001539)15.4427542
187fusion of sperm to egg plasma membrane (GO:0007342)11.4502481
188piRNA metabolic process (GO:0034587)10.6487573
189sperm motility (GO:0030317)10.4952353
190axonemal dynein complex assembly (GO:0070286)10.1690665
191striatum development (GO:0021756)1.98216419
192cardiac muscle cell development (GO:0055013)1.97255717
193negative regulation of hormone metabolic process (GO:0032351)1.96856351

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.66698058
2EZH2_22144423_ChIP-Seq_EOC_Human6.36930411
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse5.02694123
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.08861892
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.07183893
6GABP_17652178_ChIP-ChIP_JURKAT_Human2.59026559
7IGF1R_20145208_ChIP-Seq_DFB_Human2.58509424
8ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.53149786
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.36445445
10VDR_22108803_ChIP-Seq_LS180_Human2.29180357
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.28568701
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.28057923
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.19287442
14PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.10694401
15TAF15_26573619_Chip-Seq_HEK293_Human2.06946614
16FUS_26573619_Chip-Seq_HEK293_Human2.06116773
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.05654749
18EWS_26573619_Chip-Seq_HEK293_Human1.96371365
19SALL1_21062744_ChIP-ChIP_HESCs_Human1.93851982
20GATA1_26923725_Chip-Seq_HPCs_Mouse1.92652997
21E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.88442347
22PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.82633423
23ELK1_19687146_ChIP-ChIP_HELA_Human1.82567606
24FLI1_27457419_Chip-Seq_LIVER_Mouse1.80654915
25ZNF274_21170338_ChIP-Seq_K562_Hela1.79011082
26REST_21632747_ChIP-Seq_MESCs_Mouse1.78801190
27EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.74294688
28PIAS1_25552417_ChIP-Seq_VCAP_Human1.68496052
29CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.68041279
30CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.67626721
31CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.67264756
32NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.66937426
33P300_19829295_ChIP-Seq_ESCs_Human1.63565619
34PCGF2_27294783_Chip-Seq_ESCs_Mouse1.59480373
35MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.58283212
36ETS1_20019798_ChIP-Seq_JURKAT_Human1.54964777
37PADI4_21655091_ChIP-ChIP_MCF-7_Human1.52027899
38ELK4_26923725_Chip-Seq_MESODERM_Mouse1.51974019
39TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.47510005
40HTT_18923047_ChIP-ChIP_STHdh_Human1.46468352
41E2F4_17652178_ChIP-ChIP_JURKAT_Human1.45672207
42AR_21909140_ChIP-Seq_LNCAP_Human1.45377641
43* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.44705711
44RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.43285893
45TAL1_26923725_Chip-Seq_HPCs_Mouse1.42917267
46ZFP57_27257070_Chip-Seq_ESCs_Mouse1.42565764
47KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.42427851
48CBX2_27304074_Chip-Seq_ESCs_Mouse1.42287942
49JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.37970713
50MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.37144445
51RNF2_27304074_Chip-Seq_NSC_Mouse1.37051781
52TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34625377
53KDM2B_26808549_Chip-Seq_REH_Human1.33372234
54CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.32821357
55TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32789238
56POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.32789238
57TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.32115255
58IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.30177363
59CBP_20019798_ChIP-Seq_JUKART_Human1.30177363
60HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.30136799
61KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.29973027
62MYC_18940864_ChIP-ChIP_HL60_Human1.28412315
63SRF_21415370_ChIP-Seq_HL-1_Mouse1.28214772
64CTBP2_25329375_ChIP-Seq_LNCAP_Human1.28027196
65YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.27791877
66FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.27330134
67GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.27132979
68VDR_23849224_ChIP-Seq_CD4+_Human1.26754958
69NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.26698050
70GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23191006
71PCGF2_27294783_Chip-Seq_NPCs_Mouse1.23118972
72TCF4_23295773_ChIP-Seq_U87_Human1.21742245
73PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.20443100
74MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.19378428
75FLI1_21867929_ChIP-Seq_TH2_Mouse1.19317666
76STAT6_21828071_ChIP-Seq_BEAS2B_Human1.17197350
77THAP11_20581084_ChIP-Seq_MESCs_Mouse1.16276388
78OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16237676
79ER_23166858_ChIP-Seq_MCF-7_Human1.15918474
80NANOG_18555785_Chip-Seq_ESCs_Mouse1.15333610
81STAT1_17558387_ChIP-Seq_HELA_Human1.15083560
82SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.15011603
83POU5F1_16153702_ChIP-ChIP_HESCs_Human1.14556252
84WDR5_24793694_ChIP-Seq_LNCAP_Human1.13115651
85WT1_19549856_ChIP-ChIP_CCG9911_Human1.12892076
86IRF1_19129219_ChIP-ChIP_H3396_Human1.12439784
87FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.12204172
88SMAD4_21799915_ChIP-Seq_A2780_Human1.11459570
89PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.10841240
90TTF2_22483619_ChIP-Seq_HELA_Human1.09081779
91RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.08710244
92AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.08701091
93MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.08199255
94GBX2_23144817_ChIP-Seq_PC3_Human1.08078472
95EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.07914171
96SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.07705249
97NFE2_27457419_Chip-Seq_LIVER_Mouse1.07542741
98HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.07118578
99SMAD4_21741376_ChIP-Seq_EPCs_Human1.06566483
100CTBP1_25329375_ChIP-Seq_LNCAP_Human1.05100335
101AR_25329375_ChIP-Seq_VCAP_Human1.04842989
102SUZ12_27294783_Chip-Seq_NPCs_Mouse1.04828078
103CMYC_18555785_Chip-Seq_ESCs_Mouse1.04222779
104P300_18555785_Chip-Seq_ESCs_Mouse1.04176079
105FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03805767
106SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.02965138
107DROSHA_22980978_ChIP-Seq_HELA_Human1.02741318
108P53_22387025_ChIP-Seq_ESCs_Mouse1.00959316
109NANOG_16153702_ChIP-ChIP_HESCs_Human0.99712725
110SOX2_22085726_ChIP-Seq_NPCs_Mouse0.99675264
111STAT3_23295773_ChIP-Seq_U87_Human0.99308572
112EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.99227190
113EP300_21415370_ChIP-Seq_HL-1_Mouse0.99200019
114OCT4_18555785_Chip-Seq_ESCs_Mouse0.98967209
115FOXP3_21729870_ChIP-Seq_TREG_Human0.98966871
116* SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.98946500
117SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98538769
118RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98503591
119SUZ12_18555785_Chip-Seq_ESCs_Mouse0.98404120
120PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.98329212
121SOX2_16153702_ChIP-ChIP_HESCs_Human0.98161722
122CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.97746707
123DCP1A_22483619_ChIP-Seq_HELA_Human0.97739090
124GATA3_21867929_ChIP-Seq_TH1_Mouse0.97538656
125TP53_22573176_ChIP-Seq_HFKS_Human0.97333952
126* KLF5_20875108_ChIP-Seq_MESCs_Mouse0.96866410
127GF1_26923725_Chip-Seq_HPCs_Mouse0.96160767
128ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.95902538
129TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.95185131
130RUNX1_26923725_Chip-Seq_HPCs_Mouse0.94815038
131PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.94390273
132STAT3_18555785_Chip-Seq_ESCs_Mouse0.94253683
133CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.94131505
134CRX_20693478_ChIP-Seq_RETINA_Mouse0.93637185
135NR3C1_21868756_ChIP-Seq_MCF10A_Human0.93565726
136EZH2_27294783_Chip-Seq_NPCs_Mouse0.93362259
137LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.93039053
138ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.92795399
139SOX9_26525672_Chip-Seq_HEART_Mouse0.92795055
140KLF4_18555785_Chip-Seq_ESCs_Mouse0.92485718
141REST_19997604_ChIP-ChIP_NEURONS_Mouse0.91912520
142REST_18959480_ChIP-ChIP_MESCs_Mouse0.91841847
143* GABP_19822575_ChIP-Seq_HepG2_Human0.91585126
144EZH2_27304074_Chip-Seq_ESCs_Mouse0.91368468
145P53_21459846_ChIP-Seq_SAOS-2_Human0.90832795
146* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.90829019
147ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.89823492
148CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.89676097
149RBPJ_22232070_ChIP-Seq_NCS_Mouse0.88901104
150KAP1_22055183_ChIP-Seq_ESCs_Mouse0.88893350
151* SMAD3_21741376_ChIP-Seq_ESCs_Human0.88376463
152TBL1_22424771_ChIP-Seq_293T_Human0.87833775
153E2F1_18555785_Chip-Seq_ESCs_Mouse0.87507601
154RUNX1_27457419_Chip-Seq_LIVER_Mouse0.87467108
155SMAD3_21741376_ChIP-Seq_EPCs_Human0.87139037
156POU3F2_20337985_ChIP-ChIP_501MEL_Human0.86586647
157GATA3_21867929_ChIP-Seq_CD8_Mouse0.85921746
158TOP2B_26459242_ChIP-Seq_MCF-7_Human0.85714267
159RAD21_21589869_ChIP-Seq_MESCs_Mouse0.84654202
160UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.84489261
161BCAT_22108803_ChIP-Seq_LS180_Human0.84255735
162OCT1_27270436_Chip-Seq_PROSTATE_Human0.83438929

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0003698_abnormal_male_reproductive5.05586439
2MP0002837_dystrophic_cardiac_calcinosis4.96750271
3MP0008877_abnormal_DNA_methylation4.69376333
4MP0001929_abnormal_gametogenesis4.51921406
5MP0002653_abnormal_ependyma_morphology3.86371913
6MP0002210_abnormal_sex_determination3.25796462
7MP0001984_abnormal_olfaction3.00953173
8MP0004215_abnormal_myocardial_fiber2.89954489
9MP0005623_abnormal_meninges_morphology2.81590014
10MP0004084_abnormal_cardiac_muscle2.80542410
11MP0001145_abnormal_male_reproductive2.73545239
12* MP0002161_abnormal_fertility/fecundity2.73094120
13MP0002102_abnormal_ear_morphology2.51263432
14MP0004270_analgesia2.47646762
15MP0003122_maternal_imprinting2.44416695
16MP0000653_abnormal_sex_gland2.34125101
17MP0009046_muscle_twitch2.26171844
18MP0003787_abnormal_imprinting2.11006910
19MP0003121_genomic_imprinting2.10597914
20MP0002160_abnormal_reproductive_system2.05227470
21MP0002234_abnormal_pharynx_morphology2.03192148
22* MP0005410_abnormal_fertilization12.1282966
23MP0006072_abnormal_retinal_apoptosis1.87440643
24MP0001968_abnormal_touch/_nociception1.85796223
25MP0002735_abnormal_chemical_nociception1.78634157
26MP0003123_paternal_imprinting1.77966479
27MP0003137_abnormal_impulse_conducting1.75230352
28MP0002909_abnormal_adrenal_gland1.72413030
29MP0003890_abnormal_embryonic-extraembry1.71863561
30MP0002736_abnormal_nociception_after1.67694948
31MP0005330_cardiomyopathy1.67322071
32MP0003880_abnormal_central_pattern1.66278262
33MP0002734_abnormal_mechanical_nocicepti1.60308367
34MP0003329_amyloid_beta_deposits1.55640702
35MP0008775_abnormal_heart_ventricle1.55621187
36MP0003195_calcinosis1.49931510
37MP0000920_abnormal_myelination1.47987943
38MP0002272_abnormal_nervous_system1.46626713
39MP0004085_abnormal_heartbeat1.46383526
40MP0003283_abnormal_digestive_organ1.41474665
41MP0001986_abnormal_taste_sensitivity1.39115871
42MP0002938_white_spotting1.33642624
43MP0004859_abnormal_synaptic_plasticity1.32534654
44MP0004145_abnormal_muscle_electrophysio1.32130212
45MP0006292_abnormal_olfactory_placode1.30650661
46MP0005248_abnormal_Harderian_gland1.28261981
47MP0000631_abnormal_neuroendocrine_gland1.27487483
48MP0002090_abnormal_vision1.24809523
49MP0008057_abnormal_DNA_replication1.23384277
50MP0005423_abnormal_somatic_nervous1.21081496
51MP0002733_abnormal_thermal_nociception1.20523299
52MP0003635_abnormal_synaptic_transmissio1.19983906
53MP0004742_abnormal_vestibular_system1.19962944
54MP0000778_abnormal_nervous_system1.17695625
55MP0003937_abnormal_limbs/digits/tail_de1.17284747
56MP0006276_abnormal_autonomic_nervous1.17177902
57MP0005646_abnormal_pituitary_gland1.15493113
58MP0002972_abnormal_cardiac_muscle1.14707172
59MP0005377_hearing/vestibular/ear_phenot1.14087120
60MP0003878_abnormal_ear_physiology1.14087120
61MP0003567_abnormal_fetal_cardiomyocyte1.13146581
62MP0002638_abnormal_pupillary_reflex1.12316949
63MP0001970_abnormal_pain_threshold1.10226214
64MP0002064_seizures1.09501666
65MP0001486_abnormal_startle_reflex1.08166009
66MP0001905_abnormal_dopamine_level1.07937967
67MP0010030_abnormal_orbit_morphology1.07931395
68MP0002229_neurodegeneration1.07260842
69MP0002282_abnormal_trachea_morphology1.06980482
70MP0000566_synostosis1.06037010
71MP0003011_delayed_dark_adaptation1.05753923
72MP0000955_abnormal_spinal_cord1.02569401
73MP0002572_abnormal_emotion/affect_behav1.01649319
74MP0002067_abnormal_sensory_capabilities1.00586880
75MP0004510_myositis1.00327939
76MP0003634_abnormal_glial_cell1.00064350
77MP0001440_abnormal_grooming_behavior0.99706185
78MP0001529_abnormal_vocalization0.99604483
79MP0009745_abnormal_behavioral_response0.99481042
80MP0005645_abnormal_hypothalamus_physiol0.99336110
81MP0003119_abnormal_digestive_system0.98523131
82MP0003950_abnormal_plasma_membrane0.97509159
83MP0004811_abnormal_neuron_physiology0.97256755
84MP0000749_muscle_degeneration0.92688268
85MP0001944_abnormal_pancreas_morphology0.92479979
86MP0002882_abnormal_neuron_morphology0.92029266
87MP0002063_abnormal_learning/memory/cond0.91563544
88MP0002127_abnormal_cardiovascular_syste0.90988043
89MP0005187_abnormal_penis_morphology0.90874855
90MP0005084_abnormal_gallbladder_morpholo0.90308456
91MP0009780_abnormal_chondrocyte_physiolo0.89805544
92MP0005389_reproductive_system_phenotype0.88574717
93MP0002751_abnormal_autonomic_nervous0.88099319
94MP0003136_yellow_coat_color0.87154129
95MP0003631_nervous_system_phenotype0.87118306
96MP0005379_endocrine/exocrine_gland_phen0.86884928
97MP0002233_abnormal_nose_morphology0.85033328
98MP0003633_abnormal_nervous_system0.84949915
99MP0005551_abnormal_eye_electrophysiolog0.84551263
100MP0002184_abnormal_innervation0.84130725
101MP0006036_abnormal_mitochondrial_physio0.82696678
102MP0004134_abnormal_chest_morphology0.82264045
103MP0003646_muscle_fatigue0.82158769
104MP0001485_abnormal_pinna_reflex0.81637544
105MP0002269_muscular_atrophy0.81298531
106MP0004233_abnormal_muscle_weight0.80824493
107MP0004885_abnormal_endolymph0.79621429
108MP0005220_abnormal_exocrine_pancreas0.79024669
109MP0002152_abnormal_brain_morphology0.79022179
110MP0000516_abnormal_urinary_system0.78366944
111MP0005367_renal/urinary_system_phenotyp0.78366944
112MP0004858_abnormal_nervous_system0.78167754
113MP0008058_abnormal_DNA_repair0.78082226
114MP0005620_abnormal_muscle_contractility0.77942722
115MP0004484_altered_response_of0.77914345
116MP0002697_abnormal_eye_size0.77678076
117MP0009697_abnormal_copulation0.77589197
118MP0001286_abnormal_eye_development0.77406520
119MP0008932_abnormal_embryonic_tissue0.77030556
120MP0002752_abnormal_somatic_nervous0.75629014
121MP0003632_abnormal_nervous_system0.75282410
122MP0005391_vision/eye_phenotype0.74973379
123MP0003942_abnormal_urinary_system0.74802193
124MP0001765_abnormal_ion_homeostasis0.72599928
125MP0005266_abnormal_metabolism0.71685686
126MP0006035_abnormal_mitochondrial_morpho0.71404399
127MP0008995_early_reproductive_senescence0.70735553
128MP0000604_amyloidosis0.70394943
129MP0002822_catalepsy0.69136055
130MP0002084_abnormal_developmental_patter0.68998762
131MP0002066_abnormal_motor_capabilities/c0.68652533
132MP0005499_abnormal_olfactory_system0.65999726
133MP0005394_taste/olfaction_phenotype0.65999726
134MP0003861_abnormal_nervous_system0.65699574
135MP0005647_abnormal_sex_gland0.64884715
136MP0000358_abnormal_cell_content/0.64411508
137MP0008569_lethality_at_weaning0.61217275
138MP0001963_abnormal_hearing_physiology0.60997455
139MP0002557_abnormal_social/conspecific_i0.59003930
140MP0005409_darkened_coat_color0.57938997
141MP0004036_abnormal_muscle_relaxation0.55755838
142MP0003690_abnormal_glial_cell0.53823039
143MP0005386_behavior/neurological_phenoty0.53431108
144MP0004924_abnormal_behavior0.53431108
145MP0000751_myopathy0.52698049
146MP0001299_abnormal_eye_distance/0.51820353
147MP0005253_abnormal_eye_physiology0.51387465
148MP0001661_extended_life_span0.51326403
149MP0004142_abnormal_muscle_tone0.49520939
150MP0000569_abnormal_digit_pigmentation0.48312355
151MP0003879_abnormal_hair_cell0.43670900
152MP0001293_anophthalmia0.42638256
153MP0005670_abnormal_white_adipose0.42538551
154MP0000427_abnormal_hair_cycle0.42458133
155MP0003183_abnormal_peptide_metabolism0.41241203
156MP0008789_abnormal_olfactory_epithelium0.40901555
157MP0004133_heterotaxia0.40668388
158MP0010094_abnormal_chromosome_stability0.40637878
159MP0005195_abnormal_posterior_eye0.40135555
160MP0001727_abnormal_embryo_implantation0.38924973
161MP0000372_irregular_coat_pigmentation0.37425756

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)8.74418856
2Abnormal respiratory epithelium morphology (HP:0012253)8.17813758
3Abnormal respiratory motile cilium morphology (HP:0005938)8.17813758
4Rhinitis (HP:0012384)7.43880917
5Abnormal ciliary motility (HP:0012262)7.36633499
6Chronic bronchitis (HP:0004469)6.02821414
7Infertility (HP:0000789)5.51925156
8Nasal polyposis (HP:0100582)5.19861617
9Nephronophthisis (HP:0000090)4.34501450
10Bronchiectasis (HP:0002110)4.20376099
11Abnormality of the nasal mucosa (HP:0000433)4.11935624
12Bronchitis (HP:0012387)3.94256305
13Hypoglycemic coma (HP:0001325)3.90004954
14Abnormality of the lower motor neuron (HP:0002366)3.30451794
15Abnormality of the renal medulla (HP:0100957)3.26594385
16Hyperinsulinemic hypoglycemia (HP:0000825)3.14613850
17Increased hepatocellular lipid droplets (HP:0006565)3.13390276
18Sudden death (HP:0001699)3.07417366
19Recurrent otitis media (HP:0000403)3.07296070
20Acute necrotizing encephalopathy (HP:0006965)3.04739415
21Hepatic necrosis (HP:0002605)3.01281669
22Tubulointerstitial nephritis (HP:0001970)2.96366832
23Hypoglycemic seizures (HP:0002173)2.90970480
24Gonadotropin excess (HP:0000837)2.86271402
25Lipid accumulation in hepatocytes (HP:0006561)2.79340045
26Medial flaring of the eyebrow (HP:0010747)2.78663944
27Progressive macrocephaly (HP:0004481)2.77892974
28Acute encephalopathy (HP:0006846)2.76554194
29Recurrent sinusitis (HP:0011108)2.76381198
30Male infertility (HP:0003251)2.72987470
31Abnormal mitochondria in muscle tissue (HP:0008316)2.72857113
32Abnormality of midbrain morphology (HP:0002418)2.68060045
33Molar tooth sign on MRI (HP:0002419)2.68060045
34Mitochondrial inheritance (HP:0001427)2.66567968
35Amyotrophic lateral sclerosis (HP:0007354)2.64930135
36J-shaped sella turcica (HP:0002680)2.62916731
37Left ventricular hypertrophy (HP:0001712)2.62602804
38Increased CSF lactate (HP:0002490)2.61389974
39Degeneration of the lateral corticospinal tracts (HP:0002314)2.59438316
40Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.59438316
41Hepatocellular necrosis (HP:0001404)2.57200082
42Congenital malformation of the right heart (HP:0011723)2.56410844
43Double outlet right ventricle (HP:0001719)2.56410844
44Recurrent bronchitis (HP:0002837)2.55212899
45Renal Fanconi syndrome (HP:0001994)2.54834192
46Ketoacidosis (HP:0001993)2.47293166
47Hypothermia (HP:0002045)2.46575414
48Abnormality of urine glucose concentration (HP:0011016)2.42296730
49Glycosuria (HP:0003076)2.42296730
50Cerebral edema (HP:0002181)2.40401949
51Atrial fibrillation (HP:0005110)2.39738294
52Methylmalonic acidemia (HP:0002912)2.38859310
53Hyperglycinemia (HP:0002154)2.35457546
54Renal cortical cysts (HP:0000803)2.34096262
55Ventricular tachycardia (HP:0004756)2.31088509
56Spastic tetraparesis (HP:0001285)2.30961928
57Large for gestational age (HP:0001520)2.28693683
58Right ventricular cardiomyopathy (HP:0011663)2.22754788
59Neurofibrillary tangles (HP:0002185)2.22702684
60Increased serum pyruvate (HP:0003542)2.21646180
61Tubulointerstitial abnormality (HP:0001969)2.21210936
62Retinal dysplasia (HP:0007973)2.20879037
63Abnormality of the corticospinal tract (HP:0002492)2.19878421
64Intestinal atresia (HP:0011100)2.19151450
65Postaxial foot polydactyly (HP:0001830)2.18574134
66Abnormality of the labia minora (HP:0012880)2.17620847
67Calf muscle hypertrophy (HP:0008981)2.16107743
68Abnormal spermatogenesis (HP:0008669)2.14723136
69Tubular atrophy (HP:0000092)2.14621759
70Hyperglycemia (HP:0003074)2.14581442
71Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.11609338
72Decreased activity of mitochondrial respiratory chain (HP:0008972)2.11609338
73Abnormality of the calf musculature (HP:0001430)2.11117053
74Microglossia (HP:0000171)2.10938855
75Impaired proprioception (HP:0010831)2.10784826
76Fibular hypoplasia (HP:0003038)2.10369558
77Abnormality of glycine metabolism (HP:0010895)2.10079576
78Abnormality of serine family amino acid metabolism (HP:0010894)2.10079576
79Primary atrial arrhythmia (HP:0001692)2.09914088
80True hermaphroditism (HP:0010459)2.08011196
81Proximal tubulopathy (HP:0000114)2.05628555
82Hypoplasia of the capital femoral epiphysis (HP:0003090)2.05170679
83Hyperglycinuria (HP:0003108)2.04239844
84Impulsivity (HP:0100710)2.03645676
85Generalized aminoaciduria (HP:0002909)2.02941569
86Supraventricular tachycardia (HP:0004755)2.01513181
87Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.5620250
88Dynein arm defect of respiratory motile cilia (HP:0012255)11.4157251
89Absent/shortened dynein arms (HP:0200106)11.4157251
90Insidious onset (HP:0003587)1.99856383
91Termporal pattern (HP:0011008)1.99856383
92Abnormality of renal resorption (HP:0011038)1.98902879
93Increased intramyocellular lipid droplets (HP:0012240)1.97233225
94Stage 5 chronic kidney disease (HP:0003774)1.95235079
95Abnormality of glycolysis (HP:0004366)1.95231612
96Gait imbalance (HP:0002141)1.93601360
97Supraventricular arrhythmia (HP:0005115)1.91437371
98Pancreatic cysts (HP:0001737)1.90861681
99Syncope (HP:0001279)1.89631112
100Decreased motor nerve conduction velocity (HP:0003431)1.89217842
101Bundle branch block (HP:0011710)1.89083090
102Supernumerary spleens (HP:0009799)1.86856103
103Ketosis (HP:0001946)1.86428472
104Short ribs (HP:0000773)1.86367921
105Abnormality of dentin (HP:0010299)1.86157730
106Congenital primary aphakia (HP:0007707)1.85962959
107Dilated cardiomyopathy (HP:0001644)1.85757604
108Septo-optic dysplasia (HP:0100842)1.85330903
109Lactic acidosis (HP:0003128)1.84706184
110Abnormality of permanent molar morphology (HP:0011071)1.84642433
111Abnormality of the dental root (HP:0006486)1.84642433
112Taurodontia (HP:0000679)1.84642433
113Postaxial hand polydactyly (HP:0001162)1.81627074
114Cerebral inclusion bodies (HP:0100314)1.81240793
115Genital tract atresia (HP:0001827)1.81054341
116Broad distal phalanx of finger (HP:0009836)1.80987500
117Decreased testicular size (HP:0008734)1.80510732
118Muscle hypertrophy of the lower extremities (HP:0008968)1.79541859
119EEG with generalized epileptiform discharges (HP:0011198)1.77349098
120Neoplasm of the adrenal gland (HP:0100631)1.77313473
121Cortical dysplasia (HP:0002539)1.76998628
122Hypsarrhythmia (HP:0002521)1.76797005
123Abnormal gallbladder physiology (HP:0012438)1.76537143
124Cholecystitis (HP:0001082)1.76537143
125Ankle clonus (HP:0011448)1.75625628
126Vaginal atresia (HP:0000148)1.75522208
127Oculomotor apraxia (HP:0000657)1.75415081
128Sensory axonal neuropathy (HP:0003390)1.74679688
129Adrenal hypoplasia (HP:0000835)1.74426366
130Methylmalonic aciduria (HP:0012120)1.74074959
131Hyperphosphaturia (HP:0003109)1.73597174
132Gaze-evoked nystagmus (HP:0000640)1.73552508
133Bell-shaped thorax (HP:0001591)1.73374474
134Epileptiform EEG discharges (HP:0011182)1.73289372
135Palpitations (HP:0001962)1.73242258
136Abnormality of molar (HP:0011077)1.72318007
137Abnormality of molar morphology (HP:0011070)1.72318007
138Exercise intolerance (HP:0003546)1.70872083
139Abnormal pancreas size (HP:0012094)1.70602673
140Azoospermia (HP:0000027)1.70191461
141Absent frontal sinuses (HP:0002688)1.70104704
142Neoplasm of the adrenal cortex (HP:0100641)1.69771137
143Volvulus (HP:0002580)1.69672823
144Polydipsia (HP:0001959)1.69472871
145Abnormal drinking behavior (HP:0030082)1.69472871
146Absent epiphyses (HP:0010577)1.69349227
147Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.69349227
148Respiratory failure (HP:0002878)1.69271681
149Abnormality of dicarboxylic acid metabolism (HP:0010995)1.68954496
150Dicarboxylic aciduria (HP:0003215)1.68954496
151Abnormality of the dental pulp (HP:0006479)1.67619444
152Colon cancer (HP:0003003)1.67476092
153Supranuclear gaze palsy (HP:0000605)1.67366590
154Specific learning disability (HP:0001328)1.66282572
155Peripheral hypomyelination (HP:0007182)1.65974552
156Abnormality of the pancreatic islet cells (HP:0006476)1.65914578
157Abnormality of endocrine pancreas physiology (HP:0012093)1.65914578
158Increased serum lactate (HP:0002151)1.65848339
159Late onset (HP:0003584)1.65797103
160Abnormality of fatty-acid metabolism (HP:0004359)1.64758153
161Broad foot (HP:0001769)1.64412673
162Myokymia (HP:0002411)1.63696099
163Renal dysplasia (HP:0000110)1.63359281
164Heterotopia (HP:0002282)1.62637204
165Congenital hepatic fibrosis (HP:0002612)1.60574063
166Deformed sella turcica (HP:0002681)1.60306184
167Nephrogenic diabetes insipidus (HP:0009806)1.60085765
168Spastic gait (HP:0002064)1.57005962
169Pachygyria (HP:0001302)1.56472854
170Clonus (HP:0002169)1.55166965
171Aplasia/Hypoplasia of the tongue (HP:0010295)1.54394612
172Pancreatic fibrosis (HP:0100732)1.52386699
173Progressive cerebellar ataxia (HP:0002073)1.51507125
174Tubulointerstitial fibrosis (HP:0005576)1.50439202
175Upper motor neuron abnormality (HP:0002127)1.48026698
176Urinary urgency (HP:0000012)1.47906680
177Chronic sinusitis (HP:0011109)1.47095530
178Hypoplasia of the brainstem (HP:0002365)1.46822335
179Aplasia/Hypoplasia of the brainstem (HP:0007362)1.46822335
180Limb dystonia (HP:0002451)1.44320623
181Hemiparesis (HP:0001269)1.43172333
182Abnormality of the renal cortex (HP:0011035)1.39786120
183Poor coordination (HP:0002370)1.38889138

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK37.62953754
2PDK47.62953754
3PDK24.87913462
4STK394.42420211
5TESK13.75402283
6PNCK3.68466940
7WNK43.40425444
8ICK3.25548946
9PRKD33.25361098
10FRK2.80294934
11MAP4K22.45964967
12PTK2B2.36712278
13WNK12.05484510
14TRIM281.86565502
15ERBB31.82720462
16PLK41.69513393
17PLK31.64034907
18VRK21.56895485
19STK161.50868944
20NEK11.47340975
21MAPKAPK51.47088868
22MAPK151.44696194
23BRSK21.40711100
24AKT31.40571004
25BMPR1B1.40024549
26SRPK11.39525929
27CSNK1G11.36540122
28STK38L1.32728406
29BUB11.30641878
30NUAK11.30422638
31BCKDK1.30003027
32TYRO31.29765757
33GRK11.23371165
34EIF2AK11.21652963
35PRKCE1.21332107
36DYRK21.19535854
37VRK11.17308645
38TAF11.08687942
39NTRK11.08646271
40EPHB11.05079965
41OXSR11.04617462
42MYLK1.03919563
43OBSCN1.03310017
44ZAK1.01068434
45TNIK1.00800898
46EPHA40.99847818
47FER0.97535231
48PLK10.96519038
49CAMK1D0.95537077
50NEK20.95237026
51STK380.93484887
52EPHA30.92531496
53MKNK20.89678884
54LMTK20.82826051
55BRSK10.82364809
56CAMK1G0.81707136
57PDK10.80388506
58GRK50.79313282
59LATS10.77768552
60DMPK0.77324867
61TESK20.76828494
62TSSK60.76172740
63MAP3K50.74069668
64MKNK10.73422130
65INSRR0.72744760
66MAP3K40.72315799
67PAK60.71157894
68MINK10.69972904
69NTRK20.69832382
70PRKAA10.69054834
71DAPK30.67956286
72STK40.64659994
73ARAF0.63848880
74PINK10.63113427
75ADRBK20.62310485
76BCR0.58112903
77MARK10.57883656
78DYRK1B0.56823365
79CCNB10.56819523
80CDC70.55183071
81EIF2AK30.54421271
82MAP2K70.52427612
83CAMK10.52162051
84FGFR20.51773476
85AURKB0.50808035
86IRAK20.48351158
87STK240.47918871
88UHMK10.46974799
89PRKAA20.46269236
90TTK0.46246333
91ERBB40.46113313
92CDK140.45589143
93EPHB20.45400555
94MST40.43802027
95NTRK30.43549499
96CSNK2A20.43060116
97STK30.42832175
98PRKACA0.42615959
99LIMK10.42042097
100AURKA0.41732433
101ROCK10.41012590
102CHEK10.40906564
103SGK2230.39709678
104SGK4940.39709678
105CDK30.39409165
106PRKCG0.39117968
107IRAK10.38620348
108PDPK10.38528897
109CDK150.38046294
110CDK180.37473508
111CSNK1G20.36806327
112MAP3K20.36762440
113CSNK1G30.36500642
114PHKG10.36024606
115PHKG20.36024606
116MAP3K90.35963190
117KSR20.34388729
118MARK20.34065831
119NEK60.33840591
120CDK11A0.33031741
121PAK10.32864491
122CAMK2D0.32594160
123CDK50.32041976
124MET0.30899623
125PKN10.30348012
126CAMK2A0.29419043
127BRAF0.29007494
128PASK0.28180342
129MAPK130.28064105
130PLK20.26802489
131CAMK2B0.25783549
132CHEK20.25637341
133PAK30.25317168
134RET0.24979141
135WEE10.24854865
136CSNK1D0.24722523
137MAPKAPK30.23966979
138ATM0.23859200
139CDK190.23350241
140MTOR0.21899627
141PRKCQ0.21570852
142CSNK1A1L0.20617511
143EEF2K0.20058909
144CAMK2G0.19414787
145PRKACB0.17091132
146STK110.17084854
147ATR0.16816426
148RIPK40.16792706
149MAPK100.15806153
150PBK0.14944073
151CSNK1E0.14180854
152CAMKK10.14177366
153CASK0.14121334
154DYRK30.13978311
155RPS6KB10.13386194
156PRKG10.13250641
157WNK30.12549390
158GSK3B0.12124947

Predicted pathways (KEGG)

RankGene SetZ-score
1Dorso-ventral axis formation_Homo sapiens_hsa043203.61043990
2Pyruvate metabolism_Homo sapiens_hsa006203.47841148
3Protein export_Homo sapiens_hsa030603.35153041
4Vitamin B6 metabolism_Homo sapiens_hsa007503.09113021
5Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.73196867
6Olfactory transduction_Homo sapiens_hsa047402.48334617
7Maturity onset diabetes of the young_Homo sapiens_hsa049502.43237374
8Huntingtons disease_Homo sapiens_hsa050162.27598328
9Propanoate metabolism_Homo sapiens_hsa006402.25472106
10Fatty acid biosynthesis_Homo sapiens_hsa000612.23595187
11Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.20483838
12Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.18926431
13Steroid biosynthesis_Homo sapiens_hsa001002.10919606
14Ether lipid metabolism_Homo sapiens_hsa005652.08612894
15Oocyte meiosis_Homo sapiens_hsa041142.02969822
16Linoleic acid metabolism_Homo sapiens_hsa005912.01634834
17alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.00070581
18Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.93443090
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.93326269
20Glucagon signaling pathway_Homo sapiens_hsa049221.88604493
21Basal transcription factors_Homo sapiens_hsa030221.87381807
22Amphetamine addiction_Homo sapiens_hsa050311.87190756
23Synaptic vesicle cycle_Homo sapiens_hsa047211.85499727
24Butanoate metabolism_Homo sapiens_hsa006501.77596166
25Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.72533523
26Cardiac muscle contraction_Homo sapiens_hsa042601.61369637
27Fatty acid elongation_Homo sapiens_hsa000621.55555944
28Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.54275017
29Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.52588849
30Glycerolipid metabolism_Homo sapiens_hsa005611.52538383
31Taste transduction_Homo sapiens_hsa047421.52141469
32Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.49104582
332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.48632231
34Renin secretion_Homo sapiens_hsa049241.46700080
35Collecting duct acid secretion_Homo sapiens_hsa049661.44539409
36Glycerophospholipid metabolism_Homo sapiens_hsa005641.41800065
37Folate biosynthesis_Homo sapiens_hsa007901.39166094
38Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.38315121
39Mismatch repair_Homo sapiens_hsa034301.37485887
40Long-term potentiation_Homo sapiens_hsa047201.37414817
41Fanconi anemia pathway_Homo sapiens_hsa034601.31824175
42Carbohydrate digestion and absorption_Homo sapiens_hsa049731.29892348
43Dopaminergic synapse_Homo sapiens_hsa047281.26865058
44Pentose phosphate pathway_Homo sapiens_hsa000301.26646332
45Peroxisome_Homo sapiens_hsa041461.25410287
46Circadian entrainment_Homo sapiens_hsa047131.25247116
47Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.24420433
48Glutamatergic synapse_Homo sapiens_hsa047241.24161220
49Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.23659718
50Homologous recombination_Homo sapiens_hsa034401.22383321
51Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.19261486
52RNA polymerase_Homo sapiens_hsa030201.12320167
53Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.10410260
54Insulin secretion_Homo sapiens_hsa049111.09720239
55Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.06135710
56Proteasome_Homo sapiens_hsa030501.06088839
57Dilated cardiomyopathy_Homo sapiens_hsa054141.06010503
58Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.05325097
59Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.04440464
60Non-homologous end-joining_Homo sapiens_hsa034501.03562025
61Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.99269561
62Fatty acid degradation_Homo sapiens_hsa000710.98778140
63Tryptophan metabolism_Homo sapiens_hsa003800.98514099
64Morphine addiction_Homo sapiens_hsa050320.97685243
65mRNA surveillance pathway_Homo sapiens_hsa030150.96879751
66Ribosome_Homo sapiens_hsa030100.95485640
67Mineral absorption_Homo sapiens_hsa049780.94988469
68Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.94145623
69Regulation of autophagy_Homo sapiens_hsa041400.94080817
70Salivary secretion_Homo sapiens_hsa049700.93459678
71RNA degradation_Homo sapiens_hsa030180.92548052
72Phosphatidylinositol signaling system_Homo sapiens_hsa040700.91457910
73DNA replication_Homo sapiens_hsa030300.91143858
74Estrogen signaling pathway_Homo sapiens_hsa049150.88755386
75Nucleotide excision repair_Homo sapiens_hsa034200.88129691
76Calcium signaling pathway_Homo sapiens_hsa040200.86737537
77Alzheimers disease_Homo sapiens_hsa050100.86510666
78Endocytosis_Homo sapiens_hsa041440.85747777
79Base excision repair_Homo sapiens_hsa034100.85410168
80Oxidative phosphorylation_Homo sapiens_hsa001900.84918025
81Cysteine and methionine metabolism_Homo sapiens_hsa002700.83464945
82Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.82636354
83Gastric acid secretion_Homo sapiens_hsa049710.82203288
84Sphingolipid metabolism_Homo sapiens_hsa006000.81451618
85Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.81163021
86Parkinsons disease_Homo sapiens_hsa050120.80729780
87Phenylalanine metabolism_Homo sapiens_hsa003600.79223110
88Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.79055969
89Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.78953489
90One carbon pool by folate_Homo sapiens_hsa006700.78564380
91Biosynthesis of amino acids_Homo sapiens_hsa012300.77849160
92Primary bile acid biosynthesis_Homo sapiens_hsa001200.77520101
93Axon guidance_Homo sapiens_hsa043600.76627207
94Basal cell carcinoma_Homo sapiens_hsa052170.76449677
95Circadian rhythm_Homo sapiens_hsa047100.74843451
96cGMP-PKG signaling pathway_Homo sapiens_hsa040220.74781696
97Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.74107446
98Selenocompound metabolism_Homo sapiens_hsa004500.73869975
99Fatty acid metabolism_Homo sapiens_hsa012120.73512127
100Arginine and proline metabolism_Homo sapiens_hsa003300.73484856
101beta-Alanine metabolism_Homo sapiens_hsa004100.72254542
102Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.72116595
103Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.71312773
104Cocaine addiction_Homo sapiens_hsa050300.70989319
105Pentose and glucuronate interconversions_Homo sapiens_hsa000400.69720361
106Phototransduction_Homo sapiens_hsa047440.66738376
107Vascular smooth muscle contraction_Homo sapiens_hsa042700.65656372
108Serotonergic synapse_Homo sapiens_hsa047260.64502942
109Thyroid hormone synthesis_Homo sapiens_hsa049180.60798457
110Hedgehog signaling pathway_Homo sapiens_hsa043400.59756784
111Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.59555735
112Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.58754170
113Pancreatic secretion_Homo sapiens_hsa049720.58489093
114Pyrimidine metabolism_Homo sapiens_hsa002400.58015718
115Spliceosome_Homo sapiens_hsa030400.57780440
116Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.57007624
117Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.56860022
118Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.56657932
119GABAergic synapse_Homo sapiens_hsa047270.56274372
120Cholinergic synapse_Homo sapiens_hsa047250.56062138
121Nicotine addiction_Homo sapiens_hsa050330.55035327
122PPAR signaling pathway_Homo sapiens_hsa033200.54928032
123Alcoholism_Homo sapiens_hsa050340.54785069
124Hippo signaling pathway_Homo sapiens_hsa043900.54765569
125Fructose and mannose metabolism_Homo sapiens_hsa000510.53758069
126ABC transporters_Homo sapiens_hsa020100.53527220
127VEGF signaling pathway_Homo sapiens_hsa043700.52925455
128Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52543614
129Vibrio cholerae infection_Homo sapiens_hsa051100.52404875
130cAMP signaling pathway_Homo sapiens_hsa040240.52134799
131Purine metabolism_Homo sapiens_hsa002300.52093629
132Carbon metabolism_Homo sapiens_hsa012000.51089121
133Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.50707615
134Inositol phosphate metabolism_Homo sapiens_hsa005620.47647099
135Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.47434965
136Tyrosine metabolism_Homo sapiens_hsa003500.47040400
137Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.46280742
138Tight junction_Homo sapiens_hsa045300.46072033
139N-Glycan biosynthesis_Homo sapiens_hsa005100.45501799
140Cell cycle_Homo sapiens_hsa041100.44219356
141Glutathione metabolism_Homo sapiens_hsa004800.44197855
142Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.43331043
143Oxytocin signaling pathway_Homo sapiens_hsa049210.42943410
144Central carbon metabolism in cancer_Homo sapiens_hsa052300.42696300
145Sulfur metabolism_Homo sapiens_hsa009200.40593409
146Lysine degradation_Homo sapiens_hsa003100.40278118
147RNA transport_Homo sapiens_hsa030130.38451748
148Arginine biosynthesis_Homo sapiens_hsa002200.37938467
149Arachidonic acid metabolism_Homo sapiens_hsa005900.35535853
150Aldosterone synthesis and secretion_Homo sapiens_hsa049250.34812259
151Bile secretion_Homo sapiens_hsa049760.34683145
152Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.30244414
153Metabolic pathways_Homo sapiens_hsa011000.28900773

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