CLIC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 1 is a member of the p64 family; the protein localizes principally to the cell nucleus and exhibits both nuclear and plasma membrane chloride ion channel activity. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.08498323
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.08498323
3ribosomal small subunit assembly (GO:0000028)4.83462594
4antigen processing and presentation of endogenous antigen (GO:0019883)4.71675013
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.41805555
6viral transcription (GO:0019083)4.32199211
7GDP-mannose metabolic process (GO:0019673)4.28319752
8Arp2/3 complex-mediated actin nucleation (GO:0034314)4.23477600
9translational termination (GO:0006415)4.12977852
10protein maturation by protein folding (GO:0022417)4.04299429
11positive regulation of gamma-delta T cell activation (GO:0046645)3.68442617
12COPI coating of Golgi vesicle (GO:0048205)3.66386466
13Golgi transport vesicle coating (GO:0048200)3.66386466
14SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.65335963
15translational elongation (GO:0006414)3.64476845
16antigen processing and presentation via MHC class Ib (GO:0002475)3.58399130
17protein targeting to ER (GO:0045047)3.55013099
18cotranslational protein targeting to membrane (GO:0006613)3.52880026
19ribosomal small subunit biogenesis (GO:0042274)3.37743369
20establishment of protein localization to endoplasmic reticulum (GO:0072599)3.37029547
21antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.36346345
22viral life cycle (GO:0019058)3.34756792
23positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.32743360
24protein localization to endoplasmic reticulum (GO:0070972)3.31324241
25antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.29041786
26nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.23197230
27regulation of protein heterodimerization activity (GO:0043497)3.18758114
28cellular protein complex disassembly (GO:0043624)3.16972746
29negative regulation of phagocytosis (GO:0050765)3.15573686
30regulation of B cell receptor signaling pathway (GO:0050855)3.13639821
31immunoglobulin mediated immune response (GO:0016064)3.11520974
32actin nucleation (GO:0045010)3.09752721
33translational initiation (GO:0006413)3.08853065
34deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.03909571
35positive regulation of B cell differentiation (GO:0045579)2.99878355
36regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.96903770
37leukocyte aggregation (GO:0070486)2.95874218
38T cell apoptotic process (GO:0070231)2.94231903
39regulation of metalloenzyme activity (GO:0048552)2.93604987
40hepatocyte apoptotic process (GO:0097284)2.92528372
41maturation of SSU-rRNA (GO:0030490)2.90724199
42negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.88903864
43response to interferon-beta (GO:0035456)2.84805369
44antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.83567775
45DNA deamination (GO:0045006)2.82541487
46protein complex disassembly (GO:0043241)2.81929249
47membrane raft organization (GO:0031579)2.81693467
48positive regulation of lamellipodium assembly (GO:0010592)2.80466404
49regulation of interferon-beta biosynthetic process (GO:0045357)2.80317361
50regulation of superoxide anion generation (GO:0032928)2.80233274
51regulation of gamma-delta T cell differentiation (GO:0045586)2.79987838
52B cell mediated immunity (GO:0019724)2.78621752
53establishment of viral latency (GO:0019043)2.75578657
54regulation of cellular amino acid metabolic process (GO:0006521)2.73806869
55negative regulation of ligase activity (GO:0051352)2.69722002
56negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.69722002
57regulation of B cell differentiation (GO:0045577)2.67622263
58positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.65729905
59positive regulation of macrophage differentiation (GO:0045651)2.65659789
60chaperone mediated protein folding requiring cofactor (GO:0051085)2.65047000
61DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.64044333
62proteasome assembly (GO:0043248)2.63756235
63positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.62302407
64morphogenesis of an endothelium (GO:0003159)2.61316882
65endothelial tube morphogenesis (GO:0061154)2.61316882
66B cell receptor signaling pathway (GO:0050853)2.60257911
67macromolecular complex disassembly (GO:0032984)2.60090094
68negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.59507073
69mannose metabolic process (GO:0006013)2.59116541
70neutrophil activation involved in immune response (GO:0002283)2.59052404
71DNA strand elongation involved in DNA replication (GO:0006271)2.58970004
72intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.58965798
73signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.58965798
74sequestering of actin monomers (GO:0042989)2.58925048
75regulation of gamma-delta T cell activation (GO:0046643)2.58294632
76modulation by symbiont of host defense response (GO:0052031)2.57535990
77modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.57535990
78modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.57535990
79positive regulation by organism of defense response of other organism involved in symbiotic interact2.57535990
80modulation by symbiont of host immune response (GO:0052553)2.57535990
81positive regulation by symbiont of host defense response (GO:0052509)2.57535990
82lymphocyte apoptotic process (GO:0070227)2.57239288
83telomere maintenance via semi-conservative replication (GO:0032201)2.56733441
84positive regulation of interferon-alpha production (GO:0032727)2.54459662
85response to type I interferon (GO:0034340)2.54441614
86positive regulation of lamellipodium organization (GO:1902745)2.53882250
87signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.53354208
88signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.53354208
89signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.53354208
90response to interferon-alpha (GO:0035455)2.52396419
91regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.52111711
92lipopolysaccharide-mediated signaling pathway (GO:0031663)2.51441658
93regulation of interleukin-12 biosynthetic process (GO:0045075)2.51258053
94negative regulation of erythrocyte differentiation (GO:0045647)2.50548302
95regulation of type I interferon-mediated signaling pathway (GO:0060338)2.50480158
96type I interferon signaling pathway (GO:0060337)2.49888778
97cellular response to type I interferon (GO:0071357)2.49888778
98signal transduction involved in DNA integrity checkpoint (GO:0072401)2.49437935
99signal transduction involved in DNA damage checkpoint (GO:0072422)2.49437935
100barbed-end actin filament capping (GO:0051016)2.49342608
101nucleobase-containing small molecule interconversion (GO:0015949)2.49111616
102positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.48930025
103mature B cell differentiation involved in immune response (GO:0002313)2.48470970
104DNA unwinding involved in DNA replication (GO:0006268)2.46796411
105pinocytosis (GO:0006907)2.46129962
106formation of translation preinitiation complex (GO:0001731)2.45408888
107protein targeting to membrane (GO:0006612)2.45171114
108DNA strand elongation (GO:0022616)2.45007270
109NIK/NF-kappaB signaling (GO:0038061)2.44748989
110pentose-phosphate shunt (GO:0006098)2.44228203
111establishment of integrated proviral latency (GO:0075713)2.43858023
112anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.42390680
113regulation of interferon-alpha production (GO:0032647)2.41895415
114signal transduction involved in cell cycle checkpoint (GO:0072395)2.39710449
115regulation of necroptotic process (GO:0060544)2.38772988
116definitive hemopoiesis (GO:0060216)2.38039802
117negative regulation of myeloid cell apoptotic process (GO:0033033)2.38015346
118regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.37104453
119leukocyte cell-cell adhesion (GO:0007159)2.35831821
120nuclear-transcribed mRNA catabolic process (GO:0000956)2.34768293
121positive regulation of interleukin-8 secretion (GO:2000484)2.34164785
122NADPH regeneration (GO:0006740)2.33201215
123response to protozoan (GO:0001562)2.32826336
124positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.32483061
125positive thymic T cell selection (GO:0045059)2.32392831
126negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.32310773
127regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.30636634
128nucleotide-sugar biosynthetic process (GO:0009226)2.29833289
129cellular response to zinc ion (GO:0071294)2.29282202
130cellular response to interferon-beta (GO:0035458)2.29278966
131response to peptidoglycan (GO:0032494)2.28052085
132activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.28009369
133telomere maintenance via recombination (GO:0000722)2.27901480
134oligosaccharide catabolic process (GO:0009313)2.27642665
135maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.26913780
136negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.26192923
137lipopolysaccharide metabolic process (GO:0008653)2.25546369
138positive regulation of ligase activity (GO:0051351)2.24956712
139mRNA catabolic process (GO:0006402)2.24552189
1402-deoxyribonucleotide biosynthetic process (GO:0009265)2.24221171
141deoxyribose phosphate biosynthetic process (GO:0046385)2.24221171
142T cell homeostasis (GO:0043029)2.23972375
143negative regulation of stress fiber assembly (GO:0051497)2.23603676
144chaperone-mediated protein transport (GO:0072321)2.23509827
145glucose catabolic process (GO:0006007)2.23029667
146lipopolysaccharide biosynthetic process (GO:0009103)2.22861284
147negative regulation of viral genome replication (GO:0045071)2.22781568
148regulation of response to interferon-gamma (GO:0060330)2.22563809
149positive regulation of monocyte chemotaxis (GO:0090026)2.22431406
150interferon-gamma-mediated signaling pathway (GO:0060333)2.21747158
151positive regulation of natural killer cell differentiation (GO:0032825)2.21283476
152ribosomal large subunit biogenesis (GO:0042273)2.19183379
153negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.19041502
154myeloid dendritic cell activation (GO:0001773)2.18635698
155nuclear envelope reassembly (GO:0031468)2.17922649
156mitotic nuclear envelope reassembly (GO:0007084)2.17922649
157purine-containing compound salvage (GO:0043101)2.17650810
158leukocyte apoptotic process (GO:0071887)2.17325873
159positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.17145181
160fibril organization (GO:0097435)2.16562420
161glycosphingolipid catabolic process (GO:0046479)2.16144080
162regulation of mast cell degranulation (GO:0043304)2.13529103
163pentose metabolic process (GO:0019321)2.09910831

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.76586343
2* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.18092195
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.05246833
4EGR1_19374776_ChIP-ChIP_THP-1_Human2.94027901
5TP63_17297297_ChIP-ChIP_HaCaT_Human2.64103026
6* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.56839821
7MYC_22102868_ChIP-Seq_BL_Human2.55361690
8FOXM1_23109430_ChIP-Seq_U2OS_Human2.47502912
9IRF8_21731497_ChIP-ChIP_J774_Mouse2.43546617
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.42326046
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.39622776
12VDR_21846776_ChIP-Seq_THP-1_Human2.37082397
13SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.36252930
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.32237653
15MYC_18555785_ChIP-Seq_MESCs_Mouse2.21039459
16STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.20770291
17MYB_21317192_ChIP-Seq_ERMYB_Mouse2.13939541
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.11497879
19NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.06783496
20* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.06626086
21* TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.04877799
22BP1_19119308_ChIP-ChIP_Hs578T_Human2.00288323
23SCL_19346495_ChIP-Seq_HPC-7_Human1.99758165
24ELF1_17652178_ChIP-ChIP_JURKAT_Human1.99494940
25* SPI1_23547873_ChIP-Seq_NB4_Human1.91725056
26* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.89378287
27* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.88648845
28* MAF_26560356_Chip-Seq_TH1_Human1.87080450
29CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.84378039
30NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.84269320
31* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.82275832
32* MYB_26560356_Chip-Seq_TH2_Human1.79217862
33NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.78531761
34FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.77765865
35* VDR_24763502_ChIP-Seq_THP-1_Human1.73592745
36TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.72791344
37* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.72371567
38KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.71969456
39PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.71711888
40SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.71489594
41E2F4_17652178_ChIP-ChIP_JURKAT_Human1.70791571
42UTX_26944678_Chip-Seq_JUKART_Human1.70281886
43RUNX1_22412390_ChIP-Seq_EML_Mouse1.70211756
44BRD4_27068464_Chip-Seq_AML-cells_Mouse1.68961240
45IRF8_27001747_Chip-Seq_BMDM_Mouse1.65099285
46ZNF263_19887448_ChIP-Seq_K562_Human1.61894942
47ELK3_25401928_ChIP-Seq_HUVEC_Human1.61723229
48* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.61713229
49IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.60453106
50* MYB_26560356_Chip-Seq_TH1_Human1.52175985
51MYC_19079543_ChIP-ChIP_MESCs_Mouse1.48429723
52DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.47480563
53MYC_18358816_ChIP-ChIP_MESCs_Mouse1.45147984
54XRN2_22483619_ChIP-Seq_HELA_Human1.44619166
55GABP_17652178_ChIP-ChIP_JURKAT_Human1.43064640
56TCF7_22412390_ChIP-Seq_EML_Mouse1.42169823
57* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.42165076
58TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42074015
59* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.41894877
60NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.41628198
61ERG_20887958_ChIP-Seq_HPC-7_Mouse1.39387257
62* MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.37878292
63HOXB4_20404135_ChIP-ChIP_EML_Mouse1.37549547
64GATA1_22383799_ChIP-Seq_G1ME_Mouse1.35268460
65EST1_17652178_ChIP-ChIP_JURKAT_Human1.33598338
66NELFA_20434984_ChIP-Seq_ESCs_Mouse1.32780565
67CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.32777537
68CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.32469330
69TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.32087774
70CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.31810459
71* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.31124019
72VDR_23849224_ChIP-Seq_CD4+_Human1.29647897
73MYC_19030024_ChIP-ChIP_MESCs_Mouse1.29280650
74SRY_22984422_ChIP-ChIP_TESTIS_Rat1.28192197
75LXR_22292898_ChIP-Seq_THP-1_Human1.27877944
76* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.26306588
77E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.26093346
78RARG_19884340_ChIP-ChIP_MEFs_Mouse1.26055188
79GATA2_22383799_ChIP-Seq_G1ME_Mouse1.25812444
80* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.24418337
81ETS1_20019798_ChIP-Seq_JURKAT_Human1.23340978
82* SRF_21415370_ChIP-Seq_HL-1_Mouse1.23173145
83MAF_26560356_Chip-Seq_TH2_Human1.22898144
84GATA1_22025678_ChIP-Seq_K562_Human1.21866442
85FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.21358129
86TFEB_21752829_ChIP-Seq_HELA_Human1.21210822
87CIITA_25753668_ChIP-Seq_RAJI_Human1.19867532
88SPI1_23127762_ChIP-Seq_K562_Human1.17367807
89KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.17005091
90* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.16861165
91FOXP3_21729870_ChIP-Seq_TREG_Human1.16211092
92* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.16135026
93ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.15582323
94THAP11_20581084_ChIP-Seq_MESCs_Mouse1.13862571
95ELK1_19687146_ChIP-ChIP_HELA_Human1.13219391
96DCP1A_22483619_ChIP-Seq_HELA_Human1.12564112
97RACK7_27058665_Chip-Seq_MCF-7_Human1.11365332
98TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.09599253
99HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.09551768
100ELF1_20517297_ChIP-Seq_JURKAT_Human1.08835033
101* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.08826047
102* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.07651808
103NOTCH1_21737748_ChIP-Seq_TLL_Human1.07470652
104CREB1_15753290_ChIP-ChIP_HEK293T_Human1.06607407
105E2F1_21310950_ChIP-Seq_MCF-7_Human1.06508612
106JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.05789980
107NANOG_18555785_ChIP-Seq_MESCs_Mouse1.05294327
108TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03703377
109PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02986659
110BCL6_27268052_Chip-Seq_Bcells_Human1.02528819
111AR_21909140_ChIP-Seq_LNCAP_Human1.02063021
112* RUNX_20019798_ChIP-Seq_JUKART_Human1.01038208
113KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.99552532
114GABP_19822575_ChIP-Seq_HepG2_Human0.99531764
115CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98470797
116CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.98424222
117* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.97624488
118TTF2_22483619_ChIP-Seq_HELA_Human0.97040305
119CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95411677
120ZFX_18555785_ChIP-Seq_MESCs_Mouse0.95079359
121KDM2B_26808549_Chip-Seq_DND41_Human0.94858716
122ATF3_27146783_Chip-Seq_COLON_Human0.94857591
123FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.93699860
124NCOR1_26117541_ChIP-Seq_K562_Human0.92969819
125STAT3_1855785_ChIP-Seq_MESCs_Mouse0.92888664

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.10851593
2MP0003806_abnormal_nucleotide_metabolis2.63910753
3MP0000685_abnormal_immune_system2.57782095
4MP0003436_decreased_susceptibility_to2.51850493
5MP0009785_altered_susceptibility_to2.44131083
6MP0002396_abnormal_hematopoietic_system2.40278037
7MP0005671_abnormal_response_to2.30514487
8MP0003300_gastrointestinal_ulcer2.21519462
9MP0001800_abnormal_humoral_immune2.16504506
10MP0005000_abnormal_immune_tolerance2.12773332
11MP0006054_spinal_hemorrhage2.11817579
12MP0002452_abnormal_antigen_presenting2.11531400
13MP0010352_gastrointestinal_tract_polyps2.11204367
14MP0009333_abnormal_splenocyte_physiolog2.10753350
15MP0005025_abnormal_response_to2.06852638
16MP0003763_abnormal_thymus_physiology2.05545866
17MP0005451_abnormal_body_composition2.03051548
18MP0004808_abnormal_hematopoietic_stem2.01366715
19MP0002420_abnormal_adaptive_immunity1.99501360
20MP0001819_abnormal_immune_cell1.97787687
21MP0005387_immune_system_phenotype1.96760932
22MP0001790_abnormal_immune_system1.96760932
23MP0003303_peritoneal_inflammation1.94856529
24MP0002148_abnormal_hypersensitivity_rea1.93079638
25* MP0002398_abnormal_bone_marrow1.92807643
26MP0002723_abnormal_immune_serum1.91591467
27MP0002419_abnormal_innate_immunity1.91163818
28MP0008260_abnormal_autophagy1.90716883
29MP0005397_hematopoietic_system_phenotyp1.90236731
30MP0001545_abnormal_hematopoietic_system1.90236731
31MP0002166_altered_tumor_susceptibility1.89365186
32MP0000490_abnormal_crypts_of1.88387844
33MP0002405_respiratory_system_inflammati1.84103634
34MP0003693_abnormal_embryo_hatching1.81315804
35MP0010155_abnormal_intestine_physiology1.81012154
36MP0000465_gastrointestinal_hemorrhage1.77106663
37MP0004947_skin_inflammation1.75289067
38* MP0005464_abnormal_platelet_physiology1.73958190
39MP0003566_abnormal_cell_adhesion1.72612819
40MP0000858_altered_metastatic_potential1.68893042
41MP0000716_abnormal_immune_system1.68725507
42MP0000689_abnormal_spleen_morphology1.68078510
43MP0002722_abnormal_immune_system1.67665660
44MP0009278_abnormal_bone_marrow1.67242396
45MP0003724_increased_susceptibility_to1.64025540
46MP0001873_stomach_inflammation1.62521899
47MP0005058_abnormal_lysosome_morphology1.59702691
48MP0008438_abnormal_cutaneous_collagen1.57582894
49* MP0002429_abnormal_blood_cell1.54839499
50MP0001853_heart_inflammation1.54622252
51MP0005165_increased_susceptibility_to1.54485278
52MP0006082_CNS_inflammation1.53281045
53MP0005023_abnormal_wound_healing1.51937333
54MP0003075_altered_response_to1.50459227
55MP0001533_abnormal_skeleton_physiology1.49216477
56MP0002006_tumorigenesis1.47769436
57MP0002933_joint_inflammation1.44851305
58MP0008007_abnormal_cellular_replicative1.44581423
59MP0001845_abnormal_inflammatory_respons1.41108922
60MP0003705_abnormal_hypodermis_morpholog1.38270356
61MP0000703_abnormal_thymus_morphology1.34113493
62MP0010307_abnormal_tumor_latency1.33614835
63MP0004957_abnormal_blastocyst_morpholog1.32295982
64MP0003866_abnormal_defecation1.32226291
65MP0003279_aneurysm1.31257585
66MP0009764_decreased_sensitivity_to1.29784535
67MP0003950_abnormal_plasma_membrane1.28162557
68MP0002877_abnormal_melanocyte_morpholog1.27342919
69MP0000343_altered_response_to1.26583252
70MP0003448_altered_tumor_morphology1.26555242
71MP0005083_abnormal_biliary_tract1.25715655
72MP0003077_abnormal_cell_cycle1.23276814
73MP0001542_abnormal_bone_strength1.20021810
74MP0003186_abnormal_redox_activity1.19818237
75MP0002019_abnormal_tumor_incidence1.15895780
76MP0003786_premature_aging1.13215078
77MP0005257_abnormal_intraocular_pressure1.10199328
78MP0005360_urolithiasis1.05865869
79MP0005164_abnormal_response_to1.05182489
80MP0001727_abnormal_embryo_implantation1.04139559
81MP0001958_emphysema1.03792625
82MP0003111_abnormal_nucleus_morphology1.03256250
83MP0008469_abnormal_protein_level1.02245518
84MP0010094_abnormal_chromosome_stability1.01468774
85MP0009763_increased_sensitivity_to1.00944088
86MP0004272_abnormal_basement_membrane0.97359322
87MP0005174_abnormal_tail_pigmentation0.95874502
88MP0003172_abnormal_lysosome_physiology0.95714498
89MP0005166_decreased_susceptibility_to0.94839035
90MP0005275_abnormal_skin_tensile0.92031031
91MP0002132_abnormal_respiratory_system0.91091609
92MP0005076_abnormal_cell_differentiation0.90489890
93MP0000477_abnormal_intestine_morphology0.89860726
94MP0003828_pulmonary_edema0.87712893
95MP0005390_skeleton_phenotype0.87601832
96MP0004510_myositis0.85990392
97MP0003453_abnormal_keratinocyte_physiol0.83171623
98MP0005501_abnormal_skin_physiology0.83080391
99MP0001881_abnormal_mammary_gland0.82868187
100MP0000313_abnormal_cell_death0.82341932
101MP0003091_abnormal_cell_migration0.82216455
102MP0000358_abnormal_cell_content/0.81907025
103MP0000678_abnormal_parathyroid_gland0.81177538
104MP0003191_abnormal_cellular_cholesterol0.79204179
105MP0002998_abnormal_bone_remodeling0.78339149
106MP0000609_abnormal_liver_physiology0.77844691
107MP0003795_abnormal_bone_structure0.77708871
108MP0005310_abnormal_salivary_gland0.76919495
109MP0001849_ear_inflammation0.76651652
110MP0000350_abnormal_cell_proliferation0.75771980
111MP0002060_abnormal_skin_morphology0.75363856
112MP0003656_abnormal_erythrocyte_physiolo0.75339916
113MP0001243_abnormal_dermal_layer0.74950619
114MP0001915_intracranial_hemorrhage0.72970695
115MP0010234_abnormal_vibrissa_follicle0.71751871
116MP0001851_eye_inflammation0.71058421
117MP0000249_abnormal_blood_vessel0.70716907
118MP0000733_abnormal_muscle_development0.70559581
119MP0000767_abnormal_smooth_muscle0.68553402
120MP0001663_abnormal_digestive_system0.68305629
121MP0009840_abnormal_foam_cell0.66141309
122MP0001216_abnormal_epidermal_layer0.65360482
123MP0002095_abnormal_skin_pigmentation0.64134528
124MP0001879_abnormal_lymphatic_vessel0.63429467

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)4.04439500
2Recurrent abscess formation (HP:0002722)3.85308730
3Thrombocytosis (HP:0001894)3.66800448
4Petechiae (HP:0000967)3.62525010
5Eczematoid dermatitis (HP:0000976)3.58132953
6Chronic otitis media (HP:0000389)3.50969375
7Myositis (HP:0100614)3.43312292
8Hypertensive crisis (HP:0100735)3.38704121
9Abnormality of liposaccharide metabolism (HP:0010968)3.34630433
10Abnormality of glycosphingolipid metabolism (HP:0004343)3.34630433
11Abnormality of glycolipid metabolism (HP:0010969)3.34630433
12IgM deficiency (HP:0002850)3.24729628
13Abnormality of cells of the erythroid lineage (HP:0012130)3.20757880
14Recurrent bronchitis (HP:0002837)3.12699026
15Recurrent bacterial skin infections (HP:0005406)3.10287733
16Cellulitis (HP:0100658)3.03949234
17Reticulocytopenia (HP:0001896)3.03867506
18Abnormal number of erythroid precursors (HP:0012131)3.03750330
19Interstitial pulmonary disease (HP:0006530)2.99255680
20Cholecystitis (HP:0001082)2.98710624
21Abnormal gallbladder physiology (HP:0012438)2.98710624
22Recurrent viral infections (HP:0004429)2.92518619
23Hepatosplenomegaly (HP:0001433)2.89023531
24Recurrent fungal infections (HP:0002841)2.86757752
25Nasal polyposis (HP:0100582)2.86138030
26Pustule (HP:0200039)2.84813053
27Abnormality of the nasal mucosa (HP:0000433)2.84182455
28Protrusio acetabuli (HP:0003179)2.80454856
29Vacuolated lymphocytes (HP:0001922)2.74590740
30Rough bone trabeculation (HP:0100670)2.74038838
31Amyloidosis (HP:0011034)2.71741353
32Increased IgM level (HP:0003496)2.58899400
33Abnormality of T cell physiology (HP:0011840)2.58690780
34Cervical subluxation (HP:0003308)2.57385378
35Increased serum ferritin (HP:0003281)2.53322879
36Increased density of long bones (HP:0006392)2.52185996
37Abnormality of T cells (HP:0002843)2.44589101
38Abnormal platelet function (HP:0011869)2.44425137
39Impaired platelet aggregation (HP:0003540)2.44425137
40Prolonged bleeding time (HP:0003010)2.43751004
41Autoimmune thrombocytopenia (HP:0001973)2.41857218
42Abnormality of macrophages (HP:0004311)2.39514351
43Panhypogammaglobulinemia (HP:0003139)2.37448729
44Vertebral compression fractures (HP:0002953)2.35088680
45Aplastic anemia (HP:0001915)2.30327097
46Increased cerebral lipofuscin (HP:0011813)2.30222592
47Myocardial infarction (HP:0001658)2.30205797
48Gastrointestinal inflammation (HP:0004386)2.28293915
49Pallor (HP:0000980)2.28166652
50Orchitis (HP:0100796)2.27816923
51Meningitis (HP:0001287)2.27698310
52Inflammation of the large intestine (HP:0002037)2.21913484
53Recurrent skin infections (HP:0001581)2.19700242
54Abnormal platelet volume (HP:0011876)2.18917097
55Mediastinal lymphadenopathy (HP:0100721)2.17808085
56Osteolytic defects of the hand bones (HP:0009699)2.16558994
57Osteolytic defects of the phalanges of the hand (HP:0009771)2.16558994
58Reduced subcutaneous adipose tissue (HP:0003758)2.16554164
59Orthostatic hypotension (HP:0001278)2.15278345
60Agammaglobulinemia (HP:0004432)2.14977472
61Increased neuronal autofluorescent lipopigment (HP:0002074)2.14964356
62Abnormal trabecular bone morphology (HP:0100671)2.14939486
63Abnormality of cells of the lymphoid lineage (HP:0012140)2.14270916
64Spontaneous hematomas (HP:0007420)2.13848741
65Lymphopenia (HP:0001888)2.12870148
66Dysostosis multiplex (HP:0000943)2.12505253
67Osteomyelitis (HP:0002754)2.11374313
68Obstructive lung disease (HP:0006536)2.09725233
69Chronic obstructive pulmonary disease (HP:0006510)2.09725233
70Leukocytosis (HP:0001974)2.08828027
71Abnormal delayed hypersensitivity skin test (HP:0002963)2.08766684
72Urticaria (HP:0001025)2.08366835
73Skin ulcer (HP:0200042)2.05323098
74Seborrheic dermatitis (HP:0001051)2.03965877
75T lymphocytopenia (HP:0005403)2.01740646
76Cerebral aneurysm (HP:0004944)2.01626446
77Aortic aneurysm (HP:0004942)2.01286373
78Abnormality of B cell number (HP:0010975)2.00636145
79B lymphocytopenia (HP:0010976)2.00636145
80Chronic mucocutaneous candidiasis (HP:0002728)2.00382751
81Recurrent cutaneous fungal infections (HP:0011370)2.00382751
82Abnormality of T cell number (HP:0011839)1.99416409
83Increased IgE level (HP:0003212)1.99409190
84Vasculitis (HP:0002633)1.99164382
85Epistaxis (HP:0000421)1.99088922
86Premature rupture of membranes (HP:0001788)1.98402401
87IgG deficiency (HP:0004315)1.98310192
88Broad face (HP:0000283)1.97388123
89Aplasia/Hypoplasia of the sacrum (HP:0008517)1.96066369
90Hematochezia (HP:0002573)1.95281711
91Short nail (HP:0001799)1.95281023
92Onycholysis (HP:0001806)1.94577473
93Papilloma (HP:0012740)1.93421065
94Verrucae (HP:0200043)1.93421065
95Severe combined immunodeficiency (HP:0004430)1.93276576
96Poikiloderma (HP:0001029)1.93085068
97Combined immunodeficiency (HP:0005387)1.92854099
98Type I transferrin isoform profile (HP:0003642)1.92259062
99Emphysema (HP:0002097)1.91840114
100Fatigue (HP:0012378)1.91443923
101Periodontitis (HP:0000704)1.90426839
102Hypergammaglobulinemia (HP:0010702)1.89175914
103Aortic dissection (HP:0002647)1.88743418
104Increased mean platelet volume (HP:0011877)1.88334422
105Abnormality of iron homeostasis (HP:0011031)1.88205990
106Peritonitis (HP:0002586)1.87969287
107Autoimmune hemolytic anemia (HP:0001890)1.87661377
108Menorrhagia (HP:0000132)1.86670852
109Eosinophilia (HP:0001880)1.86668010
110Radial bowing (HP:0002986)1.86573010
111Joint stiffness (HP:0001387)1.86023496
112Increased serum pyruvate (HP:0003542)1.85855582
113Granulocytopenia (HP:0001913)1.85210030
114Hypertriglyceridemia (HP:0002155)1.85019393
115Ankle contracture (HP:0006466)1.84891752
116Mucopolysacchariduria (HP:0008155)1.84202059
117Urinary glycosaminoglycan excretion (HP:0003541)1.84202059
118Entropion (HP:0000621)1.83035743
119IgA deficiency (HP:0002720)1.82921762
120Colitis (HP:0002583)1.82618831
121Polycythemia (HP:0001901)1.81153613
122Glomerulopathy (HP:0100820)1.80275392
123Gastrointestinal stroma tumor (HP:0100723)1.79662459
124Skin rash (HP:0000988)1.79635542
12511 pairs of ribs (HP:0000878)1.79443979
126Lymphoma (HP:0002665)1.78988341
127Beaking of vertebral bodies (HP:0004568)1.78786519
128Axonal loss (HP:0003447)1.78543011
129Abnormality of glycolysis (HP:0004366)1.77972269
130Acute hepatic failure (HP:0006554)1.77131041
131Pulmonary infiltrates (HP:0002113)1.77052076
132Recurrent gram-negative bacterial infections (HP:0005420)1.76731589
133Macrocytic anemia (HP:0001972)1.76385542
134Bicuspid aortic valve (HP:0001647)1.73644090
135Cholelithiasis (HP:0001081)1.73258750
136Purpura (HP:0000979)1.72775521
137Abnormality of the tricuspid valve (HP:0001702)1.72732874
138Distal lower limb muscle weakness (HP:0009053)1.71560052
139Gastrointestinal dysmotility (HP:0002579)1.71504247
140Prolonged neonatal jaundice (HP:0006579)1.70891985
141Progressive neurologic deterioration (HP:0002344)1.69711047
142Aplasia/Hypoplasia of the thymus (HP:0010515)1.69189802
143Stomatitis (HP:0010280)1.68461392
144Glucose intolerance (HP:0000833)1.68094403
145Ileus (HP:0002595)1.66377479
146Increased intramyocellular lipid droplets (HP:0012240)1.65730910
147Achilles tendon contracture (HP:0001771)1.63750411
148Anorexia (HP:0002039)1.63170612
149Encephalitis (HP:0002383)1.61931298
150Oral leukoplakia (HP:0002745)1.61909930
151Chest pain (HP:0100749)1.61395104
152Abnormality of the heme biosynthetic pathway (HP:0010472)1.61221507
153Abnormality of the distal phalanges of the toes (HP:0010182)1.61136004
154Upper limb muscle weakness (HP:0003484)1.59900883
155J-shaped sella turcica (HP:0002680)1.58262038

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.33094139
2NME22.80718060
3EEF2K2.77785901
4VRK22.71523384
5TRIB32.43684670
6PIM22.36096499
7ERN12.34385401
8PKN22.29594969
9LRRK22.25790621
10KIT2.19295456
11TESK22.16815215
12BLK2.14928809
13KDR2.12001140
14STK102.06881205
15TBK12.03831905
16ZAP701.98464788
17TESK11.78813358
18RIPK41.78796596
19JAK31.74672170
20TYK21.73608404
21RPS6KA41.73389765
22BTK1.72657403
23MAP3K101.66147951
24TGFBR21.63814385
25SCYL21.50445352
26RPS6KB21.49808613
27TEC1.49771568
28MST1R1.49315357
29TAOK21.48646174
30FLT31.47698910
31MAP2K31.45930452
32PAK41.44151525
33TGFBR11.42035922
34MAPKAPK31.38944614
35TXK1.38692229
36ARAF1.36038256
37CSF1R1.35960024
38BCKDK1.35464225
39TTN1.29896909
40IKBKE1.26069101
41PBK1.25259368
42SMG11.22638359
43BUB11.21137799
44NEK21.20299223
45SYK1.08475265
46MST41.06627965
47ITK1.05951718
48PIM11.05867473
49PRPF4B1.05497639
50PTK61.05037557
51ABL21.02058911
52IKBKB1.01558342
53MAP3K111.00801405
54NEK11.00004144
55MATK0.97683965
56PDK20.96781118
57WEE10.96662339
58ILK0.95746374
59MAP3K80.94913462
60TRPM70.94394292
61LCK0.93553018
62GRK60.93516977
63MAP3K30.93414769
64IRAK40.92175374
65EIF2AK10.87562759
66HCK0.87399517
67LYN0.87057579
68CSK0.85575664
69SRPK10.83535481
70BMPR20.82792106
71BRSK20.82226165
72NEK90.79971258
73LMTK20.79957997
74FGFR40.76213430
75PASK0.75782991
76SIK30.75042373
77DAPK10.74305135
78JAK10.74259826
79MAP3K140.74120891
80CDC70.73795784
81CLK10.71893728
82LIMK10.71713484
83PAK20.70041062
84PRKG20.69613401
85ACVR1B0.69369155
86ICK0.69242657
87ERBB40.68753924
88AURKA0.67084878
89CDK60.66477049
90CCNB10.65744360
91EPHB10.65723259
92AURKB0.65176434
93EIF2AK30.65123402
94CDK40.65079627
95STK40.64567535
96GRK70.63782854
97EPHA20.62584675
98MAPKAPK20.62579531
99FES0.61318699
100NLK0.59566411
101CHUK0.57629578
102RIPK10.57553552
103DYRK30.56740999
104CDK70.55396994
105BRAF0.54098761
106TAOK30.52568214
107MAP3K10.52060390
108MAP3K60.50554895
109DYRK1B0.50411603
110RAF10.49806624
111MYLK0.49458359
112TLK10.47836179
113DAPK30.46651520
114MAP2K60.45520615
115CDK80.45266142
116IRAK30.42555353
117MOS0.41245651
118BMX0.40634672
119CAMKK20.40098925
120ATR0.40036699
121PAK10.39673337
122RPS6KA60.39659474
123TTK0.39398482
124MAP3K120.39060904
125PTK20.38034259
126MAPK110.37698181
127TIE10.37228410
128BRSK10.36960603
129VRK10.35921723
130STK160.35817313
131JAK20.35551221
132PIK3CG0.35355997

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.00972233
2DNA replication_Homo sapiens_hsa030302.78132707
3Primary immunodeficiency_Homo sapiens_hsa053402.54291854
4Leishmaniasis_Homo sapiens_hsa051402.16843233
5Antigen processing and presentation_Homo sapiens_hsa046122.12053194
6Mismatch repair_Homo sapiens_hsa034301.83496183
7Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.82101285
8Hematopoietic cell lineage_Homo sapiens_hsa046401.75897846
9Shigellosis_Homo sapiens_hsa051311.74978129
10Base excision repair_Homo sapiens_hsa034101.74338191
11Measles_Homo sapiens_hsa051621.73065911
12NF-kappa B signaling pathway_Homo sapiens_hsa040641.71917570
13Fructose and mannose metabolism_Homo sapiens_hsa000511.70516815
14Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.62545179
15B cell receptor signaling pathway_Homo sapiens_hsa046621.61065263
16Legionellosis_Homo sapiens_hsa051341.59061344
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.55942109
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.55629083
19p53 signaling pathway_Homo sapiens_hsa041151.52685430
20Osteoclast differentiation_Homo sapiens_hsa043801.51789600
21Intestinal immune network for IgA production_Homo sapiens_hsa046721.50242600
22Other glycan degradation_Homo sapiens_hsa005111.48864152
23Proteasome_Homo sapiens_hsa030501.48767025
24Apoptosis_Homo sapiens_hsa042101.46515357
25Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.44946315
26Toxoplasmosis_Homo sapiens_hsa051451.40231817
27Herpes simplex infection_Homo sapiens_hsa051681.39933467
28Leukocyte transendothelial migration_Homo sapiens_hsa046701.39398959
29Malaria_Homo sapiens_hsa051441.37192099
30Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.35206907
31Sulfur metabolism_Homo sapiens_hsa009201.35164996
32Viral myocarditis_Homo sapiens_hsa054161.35116346
33Spliceosome_Homo sapiens_hsa030401.33369588
34Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.33124607
35Toll-like receptor signaling pathway_Homo sapiens_hsa046201.32358812
36Rheumatoid arthritis_Homo sapiens_hsa053231.32113670
37Pertussis_Homo sapiens_hsa051331.32083296
38Glycosaminoglycan degradation_Homo sapiens_hsa005311.29390547
39Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.29116200
40Type I diabetes mellitus_Homo sapiens_hsa049401.28029043
41RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.27030396
42Small cell lung cancer_Homo sapiens_hsa052221.23892939
43Chronic myeloid leukemia_Homo sapiens_hsa052201.22277205
44Hepatitis B_Homo sapiens_hsa051611.22045502
45Nucleotide excision repair_Homo sapiens_hsa034201.20842476
46Cell cycle_Homo sapiens_hsa041101.19942935
47Glutathione metabolism_Homo sapiens_hsa004801.18967598
48Jak-STAT signaling pathway_Homo sapiens_hsa046301.17997640
49Salmonella infection_Homo sapiens_hsa051321.17848843
50Tuberculosis_Homo sapiens_hsa051521.11726232
51Homologous recombination_Homo sapiens_hsa034401.10356296
52Viral carcinogenesis_Homo sapiens_hsa052031.08881585
53Acute myeloid leukemia_Homo sapiens_hsa052211.07878175
54Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.07670081
55SNARE interactions in vesicular transport_Homo sapiens_hsa041301.07428183
56Influenza A_Homo sapiens_hsa051641.07160110
57Allograft rejection_Homo sapiens_hsa053301.05632783
58Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.03807201
59Platelet activation_Homo sapiens_hsa046111.01580639
60Lysosome_Homo sapiens_hsa041421.00527902
61Biosynthesis of amino acids_Homo sapiens_hsa012300.99883921
62AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.99816140
63Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.99334408
64Epstein-Barr virus infection_Homo sapiens_hsa051690.99017709
65T cell receptor signaling pathway_Homo sapiens_hsa046600.98868983
66TNF signaling pathway_Homo sapiens_hsa046680.98672413
67Carbon metabolism_Homo sapiens_hsa012000.98033966
68Pancreatic cancer_Homo sapiens_hsa052120.97607454
69HTLV-I infection_Homo sapiens_hsa051660.97175712
70Oxidative phosphorylation_Homo sapiens_hsa001900.97064883
71Pyrimidine metabolism_Homo sapiens_hsa002400.96310042
72Parkinsons disease_Homo sapiens_hsa050120.92509727
73NOD-like receptor signaling pathway_Homo sapiens_hsa046210.91782755
74Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.89714363
75Pentose phosphate pathway_Homo sapiens_hsa000300.88729711
76Transcriptional misregulation in cancer_Homo sapiens_hsa052020.87636744
77N-Glycan biosynthesis_Homo sapiens_hsa005100.87506227
78Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.85516334
79Asthma_Homo sapiens_hsa053100.85061760
80Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.85029839
81Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.82181063
82Thyroid cancer_Homo sapiens_hsa052160.81577138
83RNA transport_Homo sapiens_hsa030130.81398020
84Fatty acid elongation_Homo sapiens_hsa000620.79672333
85Graft-versus-host disease_Homo sapiens_hsa053320.78188208
86Non-homologous end-joining_Homo sapiens_hsa034500.77988689
87Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.77976463
88Bladder cancer_Homo sapiens_hsa052190.76700875
89Systemic lupus erythematosus_Homo sapiens_hsa053220.74060661
902-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.72778904
91Focal adhesion_Homo sapiens_hsa045100.71934097
92Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.71227334
93ECM-receptor interaction_Homo sapiens_hsa045120.70781712
94Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.70138695
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.70100127
96Proteoglycans in cancer_Homo sapiens_hsa052050.69260283
97Staphylococcus aureus infection_Homo sapiens_hsa051500.69053734
98Phagosome_Homo sapiens_hsa041450.67714751
99One carbon pool by folate_Homo sapiens_hsa006700.65555159
100Huntingtons disease_Homo sapiens_hsa050160.64523279
101Colorectal cancer_Homo sapiens_hsa052100.64141518
102Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.64116859
103Amoebiasis_Homo sapiens_hsa051460.63478415
104Chemokine signaling pathway_Homo sapiens_hsa040620.62403623
105Hepatitis C_Homo sapiens_hsa051600.62216474
106Renin-angiotensin system_Homo sapiens_hsa046140.62113467
107MicroRNAs in cancer_Homo sapiens_hsa052060.61970680
108Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.61890461
109Vibrio cholerae infection_Homo sapiens_hsa051100.61112106
110Caffeine metabolism_Homo sapiens_hsa002320.61051261
111HIF-1 signaling pathway_Homo sapiens_hsa040660.59657407
112VEGF signaling pathway_Homo sapiens_hsa043700.56624499
113Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.54732520
114Drug metabolism - other enzymes_Homo sapiens_hsa009830.53792018
115Neurotrophin signaling pathway_Homo sapiens_hsa047220.53589307
116Adherens junction_Homo sapiens_hsa045200.53313830
117Alzheimers disease_Homo sapiens_hsa050100.53220055
118Regulation of actin cytoskeleton_Homo sapiens_hsa048100.53125078
119RNA polymerase_Homo sapiens_hsa030200.52830324
120Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.51992783
121African trypanosomiasis_Homo sapiens_hsa051430.51118405
122Sulfur relay system_Homo sapiens_hsa041220.50832258
123Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.49834740
124Galactose metabolism_Homo sapiens_hsa000520.44744642
125Autoimmune thyroid disease_Homo sapiens_hsa053200.44647643
126Central carbon metabolism in cancer_Homo sapiens_hsa052300.43339797
127Endocytosis_Homo sapiens_hsa041440.41653142

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »