CLIC2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a chloride intracellular channel protein. Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. This protein may play a role in inhibiting the function of ryanodine receptor 2. A mutation in this gene is the cause of X-linked mental retardation-32. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)4.63644052
2immunoglobulin mediated immune response (GO:0016064)4.32918034
3regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)4.19905370
4positive regulation of gamma-delta T cell activation (GO:0046645)4.01508732
5neutrophil activation involved in immune response (GO:0002283)3.97363946
6protoporphyrinogen IX metabolic process (GO:0046501)3.95282505
7positive regulation of natural killer cell differentiation (GO:0032825)3.84899773
8regulation of hypersensitivity (GO:0002883)3.76120158
9positive regulation of B cell differentiation (GO:0045579)3.74570832
10positive regulation of interleukin-17 production (GO:0032740)3.57693808
11interferon-gamma-mediated signaling pathway (GO:0060333)3.56917677
12B cell mediated immunity (GO:0019724)3.54773082
13regulation of T-helper 1 cell differentiation (GO:0045625)3.54093931
14regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.47064279
15positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.41340126
16positive regulation of antigen processing and presentation (GO:0002579)3.41229850
17negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.36222876
18positive regulation of natural killer cell activation (GO:0032816)3.34918862
19regulation of antigen processing and presentation (GO:0002577)3.30463704
20protoporphyrinogen IX biosynthetic process (GO:0006782)3.30343969
21positive regulation of T-helper cell differentiation (GO:0045624)3.24970119
22T-helper 1 type immune response (GO:0042088)3.22960727
23oxygen transport (GO:0015671)3.22542934
24regulation of inflammatory response to antigenic stimulus (GO:0002861)3.19289574
25porphyrin-containing compound biosynthetic process (GO:0006779)3.15338645
26gas transport (GO:0015669)3.14352023
27positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.12841385
28erythrocyte development (GO:0048821)3.12067272
29regulation of T-helper cell differentiation (GO:0045622)3.10223034
30positive regulation of mast cell activation involved in immune response (GO:0033008)3.05336383
31positive regulation of mast cell degranulation (GO:0043306)3.05336383
32regulation of memory T cell differentiation (GO:0043380)3.05162380
33positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.00662942
34positive regulation of type 2 immune response (GO:0002830)2.96895742
35regulation of chronic inflammatory response (GO:0002676)2.95859057
36positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.93784051
37negative regulation of interleukin-12 production (GO:0032695)2.93407875
38defense response to protozoan (GO:0042832)2.93060163
39response to peptidoglycan (GO:0032494)2.92811208
40response to protozoan (GO:0001562)2.91208424
41hemoglobin metabolic process (GO:0020027)2.90728816
42regulation of natural killer cell activation (GO:0032814)2.90723547
43cellular response to thyroid hormone stimulus (GO:0097067)2.90471898
44tetrapyrrole biosynthetic process (GO:0033014)2.90144483
45response to interferon-beta (GO:0035456)2.90098453
46regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.88889660
47regulation of interleukin-17 production (GO:0032660)2.88779825
48regulation of dendritic cell antigen processing and presentation (GO:0002604)2.88067943
49cellular response to interferon-gamma (GO:0071346)2.87969890
50porphyrin-containing compound metabolic process (GO:0006778)2.87894722
51indolalkylamine catabolic process (GO:0046218)2.87848314
52tryptophan catabolic process (GO:0006569)2.87848314
53indole-containing compound catabolic process (GO:0042436)2.87848314
54regulation of interferon-alpha production (GO:0032647)2.84479272
55mature B cell differentiation involved in immune response (GO:0002313)2.82782468
56tryptophan metabolic process (GO:0006568)2.80789543
57regulation of B cell receptor signaling pathway (GO:0050855)2.78806723
58positive regulation of mast cell activation (GO:0033005)2.78770409
59positive regulation of defense response to virus by host (GO:0002230)2.77296576
60regulation of natural killer cell differentiation (GO:0032823)2.75048756
61response to interferon-gamma (GO:0034341)2.73527323
62positive regulation of vasculogenesis (GO:2001214)2.72935992
63positive regulation of interleukin-10 production (GO:0032733)2.70631517
64positive regulation of alpha-beta T cell proliferation (GO:0046641)2.70434881
65positive regulation of T cell proliferation (GO:0042102)2.70320720
66heme biosynthetic process (GO:0006783)2.69662274
67one-carbon compound transport (GO:0019755)2.68860218
68regulation of acute inflammatory response to antigenic stimulus (GO:0002864)2.67390922
69regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.66827260
70positive regulation of interleukin-1 beta secretion (GO:0050718)2.63843804
71positive regulation of T-helper 1 type immune response (GO:0002827)2.62031120
72heme metabolic process (GO:0042168)2.60948297
73positive regulation of interleukin-1 secretion (GO:0050716)2.58597765
74regulation of gamma-delta T cell activation (GO:0046643)2.56825141
75regulation of mast cell activation (GO:0033003)2.55845426
76positive regulation of interleukin-12 production (GO:0032735)2.54702266
77regulation of interleukin-1 beta secretion (GO:0050706)2.54188372
78kynurenine metabolic process (GO:0070189)2.53583846
79myeloid cell development (GO:0061515)2.52087282
80regulation of alpha-beta T cell proliferation (GO:0046640)2.51244785
81type I interferon signaling pathway (GO:0060337)2.50454693
82cellular response to type I interferon (GO:0071357)2.50454693
83iron ion import (GO:0097286)2.50070245
84negative regulation of nitric oxide biosynthetic process (GO:0045019)2.48294363
85purine-containing compound salvage (GO:0043101)2.47693915
86cellular response to interferon-beta (GO:0035458)2.46922762
87response to type I interferon (GO:0034340)2.46460051
88regulation of T-helper 1 type immune response (GO:0002825)2.46268792
89lipopolysaccharide-mediated signaling pathway (GO:0031663)2.46242407
90regulation of mast cell degranulation (GO:0043304)2.44863861
91positive regulation of interferon-alpha production (GO:0032727)2.43969367
92positive regulation of interferon-gamma production (GO:0032729)2.43384036
93definitive hemopoiesis (GO:0060216)2.42980240
94positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.42738641
95myeloid dendritic cell activation (GO:0001773)2.42555631
96regulation of cytokine secretion involved in immune response (GO:0002739)2.42178928
97JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.42100612
98regulation of interleukin-12 production (GO:0032655)2.42070386
99positive regulation of cAMP-mediated signaling (GO:0043950)2.41609266
100positive regulation of lymphocyte proliferation (GO:0050671)2.41073146

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.43520166
2GATA1_22025678_ChIP-Seq_K562_Human4.69025456
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.95141253
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.72069856
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.67948062
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.15038905
7SCL_19346495_ChIP-Seq_HPC-7_Human2.94149211
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.67752009
9GATA1_19941826_ChIP-Seq_K562_Human2.53458156
10IRF8_27001747_Chip-Seq_BMDM_Mouse2.52779048
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.52185991
12VDR_22108803_ChIP-Seq_LS180_Human2.30460987
13CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.28688913
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.13187433
15KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.10305596
16STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.99293461
17SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.99106748
18MYB_26560356_Chip-Seq_TH2_Human1.93938949
19EST1_17652178_ChIP-ChIP_JURKAT_Human1.85308942
20STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.83693939
21GABP_17652178_ChIP-ChIP_JURKAT_Human1.83511196
22SPI1_23547873_ChIP-Seq_NB4_Human1.83406789
23NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.83153955
24Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.81577765
25STAT4_19710469_ChIP-ChIP_TH1__Mouse1.78934654
26SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.78349127
27POU3F2_20337985_ChIP-ChIP_501MEL_Human1.77431335
28EGR1_23403033_ChIP-Seq_LIVER_Mouse1.77315480
29GATA2_19941826_ChIP-Seq_K562_Human1.72835054
30MYB_21317192_ChIP-Seq_ERMYB_Mouse1.70652824
31VDR_23849224_ChIP-Seq_CD4+_Human1.70008026
32GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.67198858
33LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.64688485
34* SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.62255826
35ELK1_19687146_ChIP-ChIP_HELA_Human1.61788886
36GATA3_26560356_Chip-Seq_TH2_Human1.59882821
37SPI1_23127762_ChIP-Seq_K562_Human1.55136260
38HOXB4_20404135_ChIP-ChIP_EML_Mouse1.54631104
39IGF1R_20145208_ChIP-Seq_DFB_Human1.54061672
40SRF_21415370_ChIP-Seq_HL-1_Mouse1.46489480
41EGR1_19374776_ChIP-ChIP_THP-1_Human1.46016449
42SMAD_19615063_ChIP-ChIP_OVARY_Human1.39915177
43RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.39225760
44RUNX_20019798_ChIP-Seq_JUKART_Human1.32569432
45SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.30008709
46MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.29858908
47LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.29084430
48MYB_26560356_Chip-Seq_TH1_Human1.28704186
49STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.27691264
50VDR_24787735_ChIP-Seq_THP-1_Human1.27115302
51SALL4_22934838_ChIP-ChIP_CD34+_Human1.25896293
52GATA3_27048872_Chip-Seq_THYMUS_Human1.25163520
53HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.20922216
54FOXP3_21729870_ChIP-Seq_TREG_Human1.20506821
55FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.20470499
56PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.17015992
57GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16974767
58TFEB_21752829_ChIP-Seq_HELA_Human1.15750560
59RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.11715555
60ZNF274_21170338_ChIP-Seq_K562_Hela1.10831774
61FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.09720673
62FLI1_27457419_Chip-Seq_LIVER_Mouse1.08834809
63EZH2_27294783_Chip-Seq_NPCs_Mouse1.07708763
64CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.07539499
65SOX2_19829295_ChIP-Seq_ESCs_Human1.06218182
66NANOG_19829295_ChIP-Seq_ESCs_Human1.06218182
67EWS_26573619_Chip-Seq_HEK293_Human1.05635901
68CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.04664424
69GATA2_21666600_ChIP-Seq_HMVEC_Human1.04133202
70GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.03543872
71FOXA1_21572438_ChIP-Seq_LNCaP_Human1.03322019
72ER_23166858_ChIP-Seq_MCF-7_Human1.02123037
73ETS1_20019798_ChIP-Seq_JURKAT_Human0.98787890
74GATA2_22383799_ChIP-Seq_G1ME_Mouse0.98529106
75IRF1_19129219_ChIP-ChIP_H3396_Human0.97934837
76GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.96760597
77SMRT_27268052_Chip-Seq_Bcells_Human0.96405847
78GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.95956916
79KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.95839875
80GATA6_21074721_ChIP-Seq_CACO-2_Human0.95745484
81TP53_22573176_ChIP-Seq_HFKS_Human0.94627190
82CIITA_25753668_ChIP-Seq_RAJI_Human0.94438009
83MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.94158380
84NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.94043056
85* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.93798420
86GATA3_26560356_Chip-Seq_TH1_Human0.93647383
87STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.92067118
88CRX_20693478_ChIP-Seq_RETINA_Mouse0.91742774
89EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.91578776
90SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88639050
91ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.88260343
92CDX2_22108803_ChIP-Seq_LS180_Human0.87991631
93NCOR1_26117541_ChIP-Seq_K562_Human0.87435568
94CREB1_15753290_ChIP-ChIP_HEK293T_Human0.87369435
95NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.87337208
96GATA1_19941827_ChIP-Seq_MEL_Mouse0.86748309
97ZFP57_27257070_Chip-Seq_ESCs_Mouse0.85926592
98CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.84651134
99CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.84254472
100HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.84239578

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004147_increased_porphyrin_level4.30980999
2MP0001835_abnormal_antigen_presentation3.87606449
3MP0003656_abnormal_erythrocyte_physiolo3.68425352
4MP0003303_peritoneal_inflammation3.36506492
5MP0002148_abnormal_hypersensitivity_rea3.13514996
6MP0003724_increased_susceptibility_to2.80140375
7MP0005671_abnormal_response_to2.78048420
8MP0009785_altered_susceptibility_to2.75568370
9MP0006082_CNS_inflammation2.55697510
10MP0005397_hematopoietic_system_phenotyp2.55362155
11MP0001545_abnormal_hematopoietic_system2.55362155
12MP0009764_decreased_sensitivity_to2.37702774
13MP0003806_abnormal_nucleotide_metabolis2.35670380
14MP0005000_abnormal_immune_tolerance2.30728728
15MP0005387_immune_system_phenotype2.25249984
16MP0001790_abnormal_immune_system2.25249984
17MP0000685_abnormal_immune_system2.15225618
18MP0001800_abnormal_humoral_immune2.06819259
19MP0005025_abnormal_response_to2.04911598
20MP0002452_abnormal_antigen_presenting2.03506416
21MP0002419_abnormal_innate_immunity1.95682553
22MP0002723_abnormal_immune_serum1.93881705
23MP0003436_decreased_susceptibility_to1.78140040
24MP0005451_abnormal_body_composition1.77011856
25MP0001819_abnormal_immune_cell1.67004454
26MP0002420_abnormal_adaptive_immunity1.65223025
27MP0005464_abnormal_platelet_physiology1.64096888
28MP0000372_irregular_coat_pigmentation1.60112577
29MP0000343_altered_response_to1.58078532
30MP0008995_early_reproductive_senescence1.57214348
31MP0003186_abnormal_redox_activity1.53980722
32MP0001845_abnormal_inflammatory_respons1.47200266
33MP0002138_abnormal_hepatobiliary_system1.47170271
34MP0002405_respiratory_system_inflammati1.45911522
35MP0008004_abnormal_stomach_pH1.44750357
36MP0002139_abnormal_hepatobiliary_system1.43689835
37MP0002398_abnormal_bone_marrow1.42743141
38MP0005167_abnormal_blood-brain_barrier1.41754498
39MP0005083_abnormal_biliary_tract1.40967527
40MP0010155_abnormal_intestine_physiology1.40330613
41MP0006054_spinal_hemorrhage1.39592037
42MP0003646_muscle_fatigue1.37977865
43MP0008469_abnormal_protein_level1.36757732
44MP0009697_abnormal_copulation1.35860732
45MP0000689_abnormal_spleen_morphology1.28618026
46MP0000716_abnormal_immune_system1.27987409
47MP0006036_abnormal_mitochondrial_physio1.27704673
48MP0003300_gastrointestinal_ulcer1.26238525
49MP0003075_altered_response_to1.20551381
50MP0009333_abnormal_splenocyte_physiolog1.20178746
51MP0009278_abnormal_bone_marrow1.17411800
52MP0005075_abnormal_melanosome_morpholog1.15136246
53MP0002429_abnormal_blood_cell1.14030615
54MP0001764_abnormal_homeostasis1.13116625
55MP0002722_abnormal_immune_system1.12944878
56MP0002166_altered_tumor_susceptibility1.12480763
57MP0001853_heart_inflammation1.12085746
58MP0009765_abnormal_xenobiotic_induced1.10589864
59MP0005647_abnormal_sex_gland1.10588594
60MP0003172_abnormal_lysosome_physiology1.10406828
61MP0005310_abnormal_salivary_gland1.09784853
62MP0005058_abnormal_lysosome_morphology1.06290421
63MP0005636_abnormal_mineral_homeostasis1.02670832
64MP0002332_abnormal_exercise_endurance1.02482487
65MP0009763_increased_sensitivity_to1.02024578
66MP0004947_skin_inflammation1.01854826
67MP0003195_calcinosis0.98704040
68MP0004808_abnormal_hematopoietic_stem0.97329102
69MP0009840_abnormal_foam_cell0.97016309
70MP0001533_abnormal_skeleton_physiology0.95108050
71MP0000015_abnormal_ear_pigmentation0.91937350
72MP0000371_diluted_coat_color0.90568051
73MP0001501_abnormal_sleep_pattern0.88368385
74MP0005166_decreased_susceptibility_to0.87501656
75MP0008875_abnormal_xenobiotic_pharmacok0.87305754
76MP0005535_abnormal_body_temperature0.86337512
77MP0003950_abnormal_plasma_membrane0.85197129
78MP0002095_abnormal_skin_pigmentation0.82811409
79MP0002006_tumorigenesis0.80496623
80MP0001873_stomach_inflammation0.77570335
81MP0005410_abnormal_fertilization0.77098139
82MP0000609_abnormal_liver_physiology0.76411341
83MP0008058_abnormal_DNA_repair0.75915321
84MP0002132_abnormal_respiratory_system0.75159719
85MP0003763_abnormal_thymus_physiology0.73915940
86MP0003786_premature_aging0.73634610
87MP0001542_abnormal_bone_strength0.73440554
88MP0000569_abnormal_digit_pigmentation0.73269870
89MP0005165_increased_susceptibility_to0.73028166
90MP0003448_altered_tumor_morphology0.68023654
91MP0001663_abnormal_digestive_system0.67480433
92MP0003045_fibrosis0.67213882
93MP0004782_abnormal_surfactant_physiolog0.66998304
94MP0008872_abnormal_physiological_respon0.66606672
95MP0000465_gastrointestinal_hemorrhage0.66073575
96MP0005319_abnormal_enzyme/_coenzyme0.65215079
97MP0009643_abnormal_urine_homeostasis0.64174526
98MP0005266_abnormal_metabolism0.64040031
99MP0006035_abnormal_mitochondrial_morpho0.62237914
100MP0002019_abnormal_tumor_incidence0.62018184

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the heme biosynthetic pathway (HP:0010472)5.47703909
2Poikilocytosis (HP:0004447)4.14500695
3Abnormality of liposaccharide metabolism (HP:0010968)4.09592282
4Abnormality of glycosphingolipid metabolism (HP:0004343)4.09592282
5Abnormality of glycolipid metabolism (HP:0010969)4.09592282
6Autoimmune thrombocytopenia (HP:0001973)3.11046182
7Abnormality of the prostate (HP:0008775)3.09482217
8Polycythemia (HP:0001901)2.97860520
9Systemic lupus erythematosus (HP:0002725)2.97368237
10Nausea (HP:0002018)2.89755828
11Autoimmune hemolytic anemia (HP:0001890)2.88503178
12Recurrent bacterial skin infections (HP:0005406)2.82707596
13Vacuolated lymphocytes (HP:0001922)2.82562199
14Paralysis (HP:0003470)2.77943890
15Optic neuritis (HP:0100653)2.69039174
16Retrobulbar optic neuritis (HP:0100654)2.69039174
17Vasculitis (HP:0002633)2.67869376
18Reticulocytosis (HP:0001923)2.67143250
19Microcytic anemia (HP:0001935)2.66241429
20Stomatitis (HP:0010280)2.64333921
21Pulmonary infiltrates (HP:0002113)2.61861155
22Abnormal hemoglobin (HP:0011902)2.60969744
23Hemoptysis (HP:0002105)2.59755984
24Recurrent abscess formation (HP:0002722)2.58025427
25Abnormality of B cell number (HP:0010975)2.55195334
26Gastrointestinal infarctions (HP:0005244)2.54435224
27Keratoconjunctivitis (HP:0001096)2.53224402
28Keratoconjunctivitis sicca (HP:0001097)2.53126973
29Myositis (HP:0100614)2.49676535
30Abnormality of iron homeostasis (HP:0011031)2.49614818
31Obstructive lung disease (HP:0006536)2.49272277
32Chronic obstructive pulmonary disease (HP:0006510)2.49272277
33Elevated erythrocyte sedimentation rate (HP:0003565)2.48365591
34Abnormality of transition element cation homeostasis (HP:0011030)2.43874605
35Exertional dyspnea (HP:0002875)2.42559151
36Albinism (HP:0001022)2.38991730
37Hypertensive crisis (HP:0100735)2.38802455
38Abnormal delayed hypersensitivity skin test (HP:0002963)2.38601069
39Increased IgM level (HP:0003496)2.36520059
40Chronic diarrhea (HP:0002028)2.30926165
41Cholelithiasis (HP:0001081)2.30101667
42Orchitis (HP:0100796)2.29680125
43Abnormality of macrophages (HP:0004311)2.29160078
44Alveolar cell carcinoma (HP:0006519)2.25631119
45Gangrene (HP:0100758)2.21437278
46B lymphocytopenia (HP:0010976)2.16079312
47Disinhibition (HP:0000734)2.15026642
48Amaurosis fugax (HP:0100576)2.14698659
49Cholecystitis (HP:0001082)2.14458283
50Abnormal gallbladder physiology (HP:0012438)2.14458283
51Increased serum ferritin (HP:0003281)2.14282643
52Hematochezia (HP:0002573)2.12136903
53Hypochromic microcytic anemia (HP:0004840)2.11312956
54Recurrent skin infections (HP:0001581)2.10899768
55Meningitis (HP:0001287)2.10873752
56Decreased electroretinogram (ERG) amplitude (HP:0000654)2.08714206
57Chest pain (HP:0100749)2.07674743
58Generalized aminoaciduria (HP:0002909)2.07253066
59Pustule (HP:0200039)2.06490515
60Leukocytosis (HP:0001974)2.06137472
61Increased cerebral lipofuscin (HP:0011813)2.05682721
62Abnormal gallbladder morphology (HP:0012437)2.05616735
63Abnormality of T cell number (HP:0011839)2.04991546
64Anorexia (HP:0002039)2.04896742
65Abnormality of T cell physiology (HP:0011840)2.03232624
66Neoplasm of the tracheobronchial system (HP:0100552)2.02095955
67Polyneuropathy (HP:0001271)2.01644354
68Granulocytopenia (HP:0001913)2.01510820
69Panhypogammaglobulinemia (HP:0003139)2.01222580
70Recurrent viral infections (HP:0004429)2.01050706
71Thrombocytosis (HP:0001894)2.00647845
72Recurrent fungal infections (HP:0002841)2.00577805
73Mutism (HP:0002300)2.00359513
74Ileus (HP:0002595)1.99336331
75Recurrent cutaneous fungal infections (HP:0011370)1.99079966
76Chronic mucocutaneous candidiasis (HP:0002728)1.99079966
77Urticaria (HP:0001025)1.98975908
78Petechiae (HP:0000967)1.97819020
79Arterial thrombosis (HP:0004420)1.96672249
80IgG deficiency (HP:0004315)1.95595971
81Skin rash (HP:0000988)1.94964786
82Pulmonary fibrosis (HP:0002206)1.94528701
83Eosinophilia (HP:0001880)1.94435161
84Cerebral hemorrhage (HP:0001342)1.93128917
85Metaphyseal dysplasia (HP:0100255)1.92629160
86Abnormality of T cells (HP:0002843)1.92375034
87Acanthocytosis (HP:0001927)1.91413871
88Abnormality of the pleura (HP:0002103)1.91190646
89Increased neuronal autofluorescent lipopigment (HP:0002074)1.87982601
90Encephalitis (HP:0002383)1.87454142
91Keratitis (HP:0000491)1.87220600
92Prostate neoplasm (HP:0100787)1.86357659
93Tinnitus (HP:0000360)1.84371462
94Dyschromatopsia (HP:0007641)1.84364482
95Fatigue (HP:0012378)1.83646761
96Interstitial pulmonary disease (HP:0006530)1.83605914
97Hepatic necrosis (HP:0002605)1.82953354
98Vertigo (HP:0002321)1.81714293
99Increased CSF lactate (HP:0002490)1.80618304
100Epistaxis (HP:0000421)1.79915239

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BMPR23.79773078
2EIF2AK13.33596802
3TAOK33.30694205
4RIPK43.07347855
5EIF2AK32.39106078
6IKBKB2.18694515
7TXK2.16265971
8GRK72.08437424
9ADRBK22.04745062
10TEC1.94398213
11MAP3K141.92341113
12FRK1.90395427
13PINK11.88777176
14BLK1.87152921
15MATK1.74805369
16SYK1.74219115
17JAK31.74103057
18IKBKE1.72906792
19TYK21.72377779
20ACVR1B1.67395139
21TBK11.64289555
22MST41.63192158
23CLK11.61056431
24CCNB11.58305631
25NUAK11.56494224
26IRAK31.51263883
27ZAK1.51191734
28KIT1.43731646
29PBK1.42217675
30TRPM71.39535852
31ERBB31.33398459
32BTK1.31455222
33LYN1.28107859
34CSF1R1.26583570
35JAK21.25841812
36PIK3CG1.24690477
37MAP4K21.22911870
38PIM11.17992203
39TLK11.13309310
40IRAK11.12908076
41MAP4K11.12146071
42DYRK31.10852506
43TAOK21.05617433
44RPS6KA50.99888241
45ITK0.96965727
46CDK190.96027156
47IRAK40.91560082
48HCK0.90064898
49JAK10.88813219
50MARK30.83830658
51SCYL20.82055324
52NME20.81178993
53MKNK10.79552722
54EPHA30.78204077
55BCKDK0.77438289
56LCK0.75602527
57BMPR1B0.74584541
58STK30.74429481
59TGFBR20.73387675
60PDK20.72226910
61CSK0.69129389
62ABL10.67564871
63BCR0.67506544
64PIM20.66592982
65OXSR10.64676791
66PRKCQ0.63738303
67STK160.62657771
68CHUK0.59949342
69MAPKAPK30.59826028
70GRK10.58626061
71MAP3K50.57984312
72STK40.57856348
73PLK40.57162478
74FES0.57076152
75RAF10.56356984
76MAP3K120.55576747
77FGR0.53838615
78TIE10.52453047
79BRSK20.50859176
80VRK10.50710229
81PRKAA20.48304377
82MAPKAPK50.45690406
83IGF1R0.45382287
84EGFR0.45102785
85PTK2B0.44555762
86PRKG20.43471442
87MYLK0.43132023
88ZAP700.42817801
89BMX0.42518277
90MAP3K40.41782003
91EIF2AK20.39253141
92GRK60.37471214
93PKN10.36710970
94PRKACG0.35931671
95PLK30.34883585
96MAPK30.34703049
97KSR20.33687175
98MAP2K30.31126203
99KSR10.30946476
100INSRR0.30391502

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053105.21686646
2Allograft rejection_Homo sapiens_hsa053304.49465204
3Intestinal immune network for IgA production_Homo sapiens_hsa046724.06217400
4Autoimmune thyroid disease_Homo sapiens_hsa053203.91890906
5Graft-versus-host disease_Homo sapiens_hsa053323.84864215
6Type I diabetes mellitus_Homo sapiens_hsa049403.36751570
7Staphylococcus aureus infection_Homo sapiens_hsa051503.16950561
8Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.82426093
9Rheumatoid arthritis_Homo sapiens_hsa053232.64726847
10Leishmaniasis_Homo sapiens_hsa051402.61751801
11Antigen processing and presentation_Homo sapiens_hsa046122.19488075
12Viral myocarditis_Homo sapiens_hsa054161.96346599
13Tuberculosis_Homo sapiens_hsa051521.64626507
14Hematopoietic cell lineage_Homo sapiens_hsa046401.60961830
15Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.59818834
16Malaria_Homo sapiens_hsa051441.57662480
17African trypanosomiasis_Homo sapiens_hsa051431.52960524
18NOD-like receptor signaling pathway_Homo sapiens_hsa046211.52958374
19Toll-like receptor signaling pathway_Homo sapiens_hsa046201.51738891
20NF-kappa B signaling pathway_Homo sapiens_hsa040641.51113507
21Herpes simplex infection_Homo sapiens_hsa051681.48864492
22Influenza A_Homo sapiens_hsa051641.48665081
23Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.40711007
24Toxoplasmosis_Homo sapiens_hsa051451.39667237
25Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.37956285
26RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.35204314
27Systemic lupus erythematosus_Homo sapiens_hsa053221.33932097
28Legionellosis_Homo sapiens_hsa051341.30435946
29Pertussis_Homo sapiens_hsa051331.30189701
30Proteasome_Homo sapiens_hsa030501.19322801
31Primary immunodeficiency_Homo sapiens_hsa053401.13455127
32Osteoclast differentiation_Homo sapiens_hsa043801.13030506
33Lysosome_Homo sapiens_hsa041421.07617145
34Jak-STAT signaling pathway_Homo sapiens_hsa046301.06908145
35Measles_Homo sapiens_hsa051621.02813756
36Phagosome_Homo sapiens_hsa041451.01494151
37Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.96232250
38TNF signaling pathway_Homo sapiens_hsa046680.90783091
39SNARE interactions in vesicular transport_Homo sapiens_hsa041300.82640348
40Oxidative phosphorylation_Homo sapiens_hsa001900.78910593
41Regulation of autophagy_Homo sapiens_hsa041400.78721427
42Collecting duct acid secretion_Homo sapiens_hsa049660.77818058
43Protein export_Homo sapiens_hsa030600.77309147
44B cell receptor signaling pathway_Homo sapiens_hsa046620.74320885
45Homologous recombination_Homo sapiens_hsa034400.72318693
46Epstein-Barr virus infection_Homo sapiens_hsa051690.68642882
47Tryptophan metabolism_Homo sapiens_hsa003800.65947641
48Linoleic acid metabolism_Homo sapiens_hsa005910.62393954
49Other glycan degradation_Homo sapiens_hsa005110.61817212
50Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.58068480
51Transcriptional misregulation in cancer_Homo sapiens_hsa052020.57182734
52Ether lipid metabolism_Homo sapiens_hsa005650.57163323
53Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.56891133
54Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.56079824
55Sulfur metabolism_Homo sapiens_hsa009200.55440791
56Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.54887478
57Olfactory transduction_Homo sapiens_hsa047400.53519940
58Chemokine signaling pathway_Homo sapiens_hsa040620.52562538
59Parkinsons disease_Homo sapiens_hsa050120.51678027
60alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.51461494
61Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.50593029
62Basal transcription factors_Homo sapiens_hsa030220.49067834
63Primary bile acid biosynthesis_Homo sapiens_hsa001200.48885498
64Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.47379508
65Selenocompound metabolism_Homo sapiens_hsa004500.47338192
66Salmonella infection_Homo sapiens_hsa051320.45908413
67Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.43636886
68Arachidonic acid metabolism_Homo sapiens_hsa005900.40963124
69Hepatitis B_Homo sapiens_hsa051610.37370742
70Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.34795259
71Glycosaminoglycan degradation_Homo sapiens_hsa005310.34593757
72Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.34526725
73Propanoate metabolism_Homo sapiens_hsa006400.33616411
74Nitrogen metabolism_Homo sapiens_hsa009100.32936674
75Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.32840107
76Sphingolipid metabolism_Homo sapiens_hsa006000.32756727
77Hepatitis C_Homo sapiens_hsa051600.32580137
78Non-homologous end-joining_Homo sapiens_hsa034500.31327729
79Complement and coagulation cascades_Homo sapiens_hsa046100.31307104
80Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.30960400
81Platelet activation_Homo sapiens_hsa046110.30814640
82Shigellosis_Homo sapiens_hsa051310.30719520
83Apoptosis_Homo sapiens_hsa042100.30023278
84Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.29492207
85Glutathione metabolism_Homo sapiens_hsa004800.29311899
86RNA degradation_Homo sapiens_hsa030180.28887790
87Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.28285606
88Butanoate metabolism_Homo sapiens_hsa006500.26113632
89ABC transporters_Homo sapiens_hsa020100.25800756
90Phototransduction_Homo sapiens_hsa047440.25548409
91T cell receptor signaling pathway_Homo sapiens_hsa046600.24694307
92One carbon pool by folate_Homo sapiens_hsa006700.23624714
93Mineral absorption_Homo sapiens_hsa049780.22971803
94HTLV-I infection_Homo sapiens_hsa051660.22753890
95Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.22468909
96Chemical carcinogenesis_Homo sapiens_hsa052040.20727561
97Fanconi anemia pathway_Homo sapiens_hsa034600.20031180
98Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.18706325
99Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.18692711
100Prolactin signaling pathway_Homo sapiens_hsa049170.18671838

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