CLIC3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 3 is a member of the p64 family and is predominantly localized in the nucleus and stimulates chloride ion channel activity. In addition, this protein may participate in cellular growth control, based on its association with ERK7, a member of the MAP kinase family. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1surfactant homeostasis (GO:0043129)9.16110681
2glomerular visceral epithelial cell development (GO:0072015)9.06002895
3establishment of skin barrier (GO:0061436)8.65229786
4chemical homeostasis within a tissue (GO:0048875)8.32709024
5glomerular epithelial cell development (GO:0072310)8.23767315
6regulation of water loss via skin (GO:0033561)8.07356617
7sphingoid metabolic process (GO:0046519)6.62719164
8multicellular organismal water homeostasis (GO:0050891)6.59531431
9keratinization (GO:0031424)6.37801676
10glomerular basement membrane development (GO:0032836)6.34399103
11regulation of B cell receptor signaling pathway (GO:0050855)6.27329995
12sphingosine metabolic process (GO:0006670)6.07570935
13thyroid hormone generation (GO:0006590)5.71962241
14water homeostasis (GO:0030104)5.65629922
15leukocyte aggregation (GO:0070486)5.42897331
16diol metabolic process (GO:0034311)5.40832343
17regulation of glomerular filtration (GO:0003093)5.40619704
18hemidesmosome assembly (GO:0031581)5.38050387
19antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.32423894
20regulation of ruffle assembly (GO:1900027)5.28614524
21regulation of cell proliferation involved in kidney development (GO:1901722)5.24471807
22keratinocyte differentiation (GO:0030216)5.05829153
23keratinocyte proliferation (GO:0043616)5.00535891
24interferon-gamma secretion (GO:0072643)4.79896875
25bundle of His cell to Purkinje myocyte communication (GO:0086069)4.74354183
26cyclooxygenase pathway (GO:0019371)4.66219067
27negative regulation of cell killing (GO:0031342)4.64255296
28negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.64255296
29regulation of natural killer cell mediated immunity (GO:0002715)4.55147941
30regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.55147941
31thyroid hormone metabolic process (GO:0042403)4.51725703
32positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.50399538
33renal system process involved in regulation of blood volume (GO:0001977)4.40612209
34negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)4.37372012
35regulation of activation of Janus kinase activity (GO:0010533)4.36810994
36regulation of transforming growth factor beta1 production (GO:0032908)4.36061062
37positive regulation of natural killer cell mediated immunity (GO:0002717)4.27901449
38antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.09321836
39positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.06361698
40epidermal cell differentiation (GO:0009913)4.04588130
41viral transcription (GO:0019083)4.04302770
42cellular response to interleukin-15 (GO:0071350)4.02166852
43positive regulation of monocyte chemotaxis (GO:0090026)3.99946133
44glucosamine-containing compound catabolic process (GO:1901072)3.98332902
45positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.96106680
46regulation of integrin-mediated signaling pathway (GO:2001044)3.94558059
47activation of MAPKKK activity (GO:0000185)3.90541096
48peptide cross-linking (GO:0018149)3.90251519
49dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.89630011
50macrophage chemotaxis (GO:0048246)3.87714614
51lymphangiogenesis (GO:0001946)3.83449791
52translational termination (GO:0006415)3.79711034
53cytidine deamination (GO:0009972)3.79503850
54cytidine metabolic process (GO:0046087)3.79503850
55cytidine catabolic process (GO:0006216)3.79503850
56calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.78233350
57antigen processing and presentation of endogenous antigen (GO:0019883)3.75003731
58glomerulus development (GO:0032835)3.74290707
59regulation of leukocyte mediated cytotoxicity (GO:0001910)3.74266838
60thymic T cell selection (GO:0045061)3.73097725
61positive regulation of interleukin-8 secretion (GO:2000484)3.72953913
62negative regulation of T cell apoptotic process (GO:0070233)3.71727875
63regulation of phospholipase A2 activity (GO:0032429)3.70052996
64antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.66571237
65ribosomal small subunit biogenesis (GO:0042274)3.66374482
66neutrophil activation (GO:0042119)3.62481380
67tight junction assembly (GO:0070830)3.62400594
68positive regulation of T cell mediated cytotoxicity (GO:0001916)3.61389906
69epidermis development (GO:0008544)3.56930771
70negative regulation of stress fiber assembly (GO:0051497)3.53553827
71neutrophil activation involved in immune response (GO:0002283)3.52890130
72regulation of chemokine secretion (GO:0090196)3.50715066
73long-chain fatty acid biosynthetic process (GO:0042759)3.45858698
74Arp2/3 complex-mediated actin nucleation (GO:0034314)3.45109184
75wound healing, spreading of epidermal cells (GO:0035313)3.45101714
76hair cycle (GO:0042633)3.42984450
77molting cycle (GO:0042303)3.42984450
78negative T cell selection (GO:0043383)3.42496217
79positive regulation of cell killing (GO:0031343)3.41629587
80granulocyte activation (GO:0036230)3.39953889
81renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.39016506
82negative regulation of cell fate specification (GO:0009996)3.37559220
83negative regulation of interleukin-2 production (GO:0032703)3.34027721
84regulation of cardioblast differentiation (GO:0051890)3.33686181
85positive thymic T cell selection (GO:0045059)3.33051326
86cytolysis (GO:0019835)3.32418894
87regulation of vasculogenesis (GO:2001212)3.31911419
88ectoderm development (GO:0007398)3.30555917
89ribosomal small subunit assembly (GO:0000028)3.28792962
90keratinocyte development (GO:0003334)3.27895073
91regulation of T cell mediated cytotoxicity (GO:0001914)3.25798687
92fatty acid elongation (GO:0030497)3.24648462
93positive regulation of epidermal cell differentiation (GO:0045606)3.24349572
94regulation of cell killing (GO:0031341)3.18644609
95positive T cell selection (GO:0043368)3.18364269
96regulation of defense response to virus by virus (GO:0050690)3.16960315
97pyrimidine ribonucleoside catabolic process (GO:0046133)3.16099830
98T cell selection (GO:0045058)3.14444761
99cellular defense response (GO:0006968)3.14114270
100prostanoid metabolic process (GO:0006692)3.12184995
101prostaglandin metabolic process (GO:0006693)3.12184995
102negative regulation of kidney development (GO:0090185)3.11820920
103positive regulation of chemokine secretion (GO:0090197)3.11076268
104response to type I interferon (GO:0034340)3.10300068
105regulation of interleukin-8 secretion (GO:2000482)3.08934720
106cellular response to type I interferon (GO:0071357)3.08627983
107type I interferon signaling pathway (GO:0060337)3.08627983
108negative regulation of axon guidance (GO:1902668)3.08427616
109negative regulation of axon extension involved in axon guidance (GO:0048843)3.07895786
110regulation of glomerulus development (GO:0090192)3.05558600
111induction of positive chemotaxis (GO:0050930)3.05441320
112skin morphogenesis (GO:0043589)3.05259156
113lymphocyte migration (GO:0072676)3.04632771
114prostanoid biosynthetic process (GO:0046457)3.04097404
115prostaglandin biosynthetic process (GO:0001516)3.04097404
116positive regulation of glomerulus development (GO:0090193)3.03747240
117intermediate filament organization (GO:0045109)3.03442062
118positive regulation of keratinocyte differentiation (GO:0045618)3.03368784
119negative thymic T cell selection (GO:0045060)3.03322286
120protein localization to endosome (GO:0036010)3.01462324
121regulation of endothelial cell chemotaxis (GO:2001026)3.01102717
122mast cell activation (GO:0045576)2.98791223
123viral life cycle (GO:0019058)2.98636998
124protein maturation by protein folding (GO:0022417)2.98432621
125SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.98148277
126response to interleukin-15 (GO:0070672)2.97807620
127protein targeting to ER (GO:0045047)2.94531790
128regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.93137931
129cotranslational protein targeting to membrane (GO:0006613)2.92594115
130positive regulation of endothelial cell differentiation (GO:0045603)2.92321322
131translational elongation (GO:0006414)2.90717980
132sphingomyelin metabolic process (GO:0006684)2.90628318
133intestinal epithelial cell development (GO:0060576)2.89608660
134maturation of SSU-rRNA (GO:0030490)2.88723049
135leukocyte degranulation (GO:0043299)2.88477276
136negative regulation of phagocytosis (GO:0050765)2.85433884
137negative regulation of interferon-gamma production (GO:0032689)2.85204791
138respiratory tube development (GO:0030323)2.84699367
139actin nucleation (GO:0045010)2.84682746
140establishment of protein localization to endoplasmic reticulum (GO:0072599)2.83844875
141lymph vessel development (GO:0001945)2.83124897
142dendritic cell chemotaxis (GO:0002407)2.82413439
143linoleic acid metabolic process (GO:0043651)2.81158998
144regulation of T cell apoptotic process (GO:0070232)2.81026992
145negative regulation of actin filament bundle assembly (GO:0032232)2.80549722
146positive regulation of p38MAPK cascade (GO:1900745)2.80367050
147cellular protein complex disassembly (GO:0043624)2.80175748
148lung alveolus development (GO:0048286)2.79182281
149negative regulation of viral genome replication (GO:0045071)2.78935343
150detection of bacterium (GO:0016045)2.78832765
151phospholipid scrambling (GO:0017121)2.78611401
152lipoxygenase pathway (GO:0019372)2.78532936
153gland morphogenesis (GO:0022612)2.78531632
154protein localization to endoplasmic reticulum (GO:0070972)2.77208400
155immunoglobulin mediated immune response (GO:0016064)2.76980694
156T cell migration (GO:0072678)2.76927046
157sodium-independent organic anion transport (GO:0043252)2.76799424
158regulation of axon guidance (GO:1902667)2.76552914
159negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.76542094
160hepatocyte apoptotic process (GO:0097284)2.76374544
161C21-steroid hormone biosynthetic process (GO:0006700)2.75774768
162regulation of monocyte chemotaxis (GO:0090025)2.75208493
163positive regulation of gamma-delta T cell activation (GO:0046645)2.74473185
164atrioventricular valve morphogenesis (GO:0003181)2.72995147
165regulation of axon extension involved in axon guidance (GO:0048841)2.71983856
166T cell receptor signaling pathway (GO:0050852)2.71461280
167wound healing, spreading of cells (GO:0044319)2.70794370
168negative regulation of cell fate commitment (GO:0010454)2.70644584
169membrane raft organization (GO:0031579)2.69879551
170establishment of epithelial cell polarity (GO:0090162)2.69876072
171detection of other organism (GO:0098543)2.68803445
172negative regulation of lymphocyte apoptotic process (GO:0070229)2.68703668
173regulation of hypersensitivity (GO:0002883)2.67834807
174myeloid cell activation involved in immune response (GO:0002275)2.66825534
175positive regulation of epidermis development (GO:0045684)2.66463225
176positive regulation of interleukin-4 production (GO:0032753)2.66279195
177G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.63653595
178response to interferon-beta (GO:0035456)2.61684671
179regulation of T cell chemotaxis (GO:0010819)2.59776254
180positive regulation of T cell chemotaxis (GO:0010820)2.59776254
181negative regulation of leukocyte mediated immunity (GO:0002704)2.58473563
182desmosome organization (GO:0002934)10.4232282

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse6.88382183
2TRIM28_21343339_ChIP-Seq_HEK293_Human3.36705482
3ESR1_21235772_ChIP-Seq_MCF-7_Human3.14511716
4IRF8_22096565_ChIP-ChIP_GC-B_Human2.96264542
5P63_26484246_Chip-Seq_KERATINOCYTES_Human2.80784979
6ESR2_21235772_ChIP-Seq_MCF-7_Human2.78264605
7SOX9_24532713_ChIP-Seq_HFSC_Mouse2.71314691
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.67218187
9SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.65157661
10RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.59176249
11RARG_19884340_ChIP-ChIP_MEFs_Mouse2.45029183
12STAT6_21828071_ChIP-Seq_BEAS2B_Human2.24159102
13SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.06739078
14SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.06739078
15IRF8_21731497_ChIP-ChIP_J774_Mouse2.05223025
16TP63_17297297_ChIP-ChIP_HaCaT_Human11.8991400
17GATA1_22025678_ChIP-Seq_K562_Human1.99929876
18IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.97293174
19PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.96601744
20ELK3_25401928_ChIP-Seq_HUVEC_Human1.96435699
21MAF_26560356_Chip-Seq_TH1_Human1.95638638
22BP1_19119308_ChIP-ChIP_Hs578T_Human1.95395040
23MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.95205757
24ZNF217_24962896_ChIP-Seq_MCF-7_Human1.92318051
25FOXO3_23340844_ChIP-Seq_DLD1_Human1.92089356
26* SOX2_20726797_ChIP-Seq_SW620_Human1.89056519
27UTX_26944678_Chip-Seq_JUKART_Human1.88393952
28TCF4_18268006_ChIP-ChIP_LS174T_Human1.86633536
29NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.83059976
30BCL6_27268052_Chip-Seq_Bcells_Human1.81324231
31STAT4_19710469_ChIP-ChIP_TH1__Mouse1.78533732
32MYB_26560356_Chip-Seq_TH2_Human1.74613648
33MAF_26560356_Chip-Seq_TH2_Human1.74146177
34GATA4_25053715_ChIP-Seq_YYC3_Human1.72409676
35SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.67014511
36VDR_21846776_ChIP-Seq_THP-1_Human1.66931522
37PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.66646103
38LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.66345286
39RUNX1_22412390_ChIP-Seq_EML_Mouse1.64667719
40E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.64495621
41BCOR_27268052_Chip-Seq_Bcells_Human1.63290142
42ZNF263_19887448_ChIP-Seq_K562_Human1.61508379
43RUNX_20019798_ChIP-Seq_JUKART_Human1.60954717
44KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.60896192
45TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60794522
46TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.59652749
47CDX2_20551321_ChIP-Seq_CACO-2_Human1.56994160
48FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.56438424
49ELF1_20517297_ChIP-Seq_JURKAT_Human1.54467268
50TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.54139827
51STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.53801558
52CJUN_26792858_Chip-Seq_BT549_Human1.51337580
53MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.49852388
54P68_20966046_ChIP-Seq_HELA_Human1.48123921
55RUNX1_27514584_Chip-Seq_MCF-7_Human1.47452133
56KDM2B_26808549_Chip-Seq_SUP-B15_Human1.47391801
57TCF7_22412390_ChIP-Seq_EML_Mouse1.47389643
58SOX2_27498859_Chip-Seq_STOMACH_Mouse1.47215453
59AHR_22903824_ChIP-Seq_MCF-7_Human1.46718498
60E2F1_20622854_ChIP-Seq_HELA_Human1.46613978
61ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.46300910
62ESR1_20079471_ChIP-ChIP_T-47D_Human1.46215821
63KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.46015518
64VDR_24763502_ChIP-Seq_THP-1_Human1.45104800
65PPAR_26484153_Chip-Seq_NCI-H1993_Human1.44783225
66GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.44261101
67FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.43164505
68* SMC4_20622854_ChIP-Seq_HELA_Human1.41480554
69GATA2_21666600_ChIP-Seq_HMVEC_Human1.41185404
70CTCF_27219007_Chip-Seq_ERYTHROID_Human1.40579082
71KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.39641819
72BRD4_27068464_Chip-Seq_AML-cells_Mouse1.38770089
73SA1_27219007_Chip-Seq_Bcells_Human1.38530281
74KLF5_25053715_ChIP-Seq_YYC3_Human1.38410585
75MYB_26560356_Chip-Seq_TH1_Human1.36722005
76HIF1A_21447827_ChIP-Seq_MCF-7_Human1.35619459
77KDM2B_26808549_Chip-Seq_DND41_Human1.35240299
78TP63_23658742_ChIP-Seq_EP156T_Human1.34441069
79* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.33357525
80ELF1_17652178_ChIP-ChIP_JURKAT_Human1.31931879
81TET1_21451524_ChIP-Seq_MESCs_Mouse1.31714747
82FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.30945661
83SRY_22984422_ChIP-ChIP_TESTIS_Rat1.30141802
84TP53_18474530_ChIP-ChIP_U2OS_Human1.29907194
85GATA3_24758297_ChIP-Seq_MCF-7_Human1.29886533
86CTCF_20526341_ChIP-Seq_ESCs_Human1.29358714
87RACK7_27058665_Chip-Seq_MCF-7_Human1.27827807
88RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.27822480
89* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.27221772
90STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.26780111
91LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.25733871
92CLOCK_20551151_ChIP-Seq_293T_Human1.23108368
93GATA3_27048872_Chip-Seq_THYMUS_Human1.21895742
94* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.20088033
95* SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.19362058
96FOXM1_26456572_ChIP-Seq_MCF-7_Human1.19157853
97SPI1_23127762_ChIP-Seq_K562_Human1.18045772
98CTCF_27219007_Chip-Seq_Bcells_Human1.17647818
99NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.17612688
100TP63_22573176_ChIP-Seq_HFKS_Human1.15895469
101TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.15331857
102SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.14875458
103CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.14389958
104SPI1_23547873_ChIP-Seq_NB4_Human1.14322503
105MYC_22102868_ChIP-Seq_BL_Human1.13918502
106SALL4_18804426_ChIP-ChIP_XEN_Mouse1.11013251
107IRF8_27001747_Chip-Seq_BMDM_Mouse1.09361268
108PHF8_20622854_ChIP-Seq_HELA_Human1.09340436
109RXR_22108803_ChIP-Seq_LS180_Human1.09266259
110BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.08794543
111PPARA_22158963_ChIP-Seq_LIVER_Mouse1.08513759
112GATA6_25053715_ChIP-Seq_YYC3_Human1.07602458
113P300_27268052_Chip-Seq_Bcells_Human1.04730330
114CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04102715
115YY1_22570637_ChIP-Seq_MALME-3M_Human1.03311385
116CTCF_21964334_Chip-Seq_Bcells_Human1.03152627
117ATF3_27146783_Chip-Seq_COLON_Human1.02646557
118CTCF_26484167_Chip-Seq_Bcells_Mouse1.01213898
119CTCF_21964334_ChIP-Seq_BJAB-B_Human1.01054124
120UBF1/2_26484160_Chip-Seq_HMECs_Human1.00181690
121CDX2_19796622_ChIP-Seq_MESCs_Mouse0.99970124
122ARNT_22903824_ChIP-Seq_MCF-7_Human0.99235444
123JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98700402
124TP53_20018659_ChIP-ChIP_R1E_Mouse0.98148941
125ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.96314518
126THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.94327313
127FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.94248680
128JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92729532
129ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.91777810
130GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.91574546
131RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.89332651
132TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88346163
133TBX20_22328084_ChIP-Seq_HEART_Mouse0.87742496
134TBX20_22080862_ChIP-Seq_HEART_Mouse0.87742496
135CEBPB_22108803_ChIP-Seq_LS180_Human0.86542288
136FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.85959945
137EED_16625203_ChIP-ChIP_MESCs_Mouse0.85921166
138SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.84973731
139VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.84931724
140EP300_21415370_ChIP-Seq_HL-1_Mouse0.84930094
141BCAT_22108803_ChIP-Seq_LS180_Human0.84834521
142ERG_21242973_ChIP-ChIP_JURKAT_Human0.81607364
143SMAD3_21741376_ChIP-Seq_HESCs_Human0.81509469
144FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.81486400
145WT1_25993318_ChIP-Seq_PODOCYTE_Human0.78996925
146LXR_22158963_ChIP-Seq_LIVER_Mouse0.77953539
147RXR_22158963_ChIP-Seq_LIVER_Mouse0.77243493
148TCF3_18692474_ChIP-Seq_MEFs_Mouse0.76544848
149SUZ12_27294783_Chip-Seq_ESCs_Mouse0.74313296
150KDM2B_26808549_Chip-Seq_K562_Human0.72686111
151* LXR_22292898_ChIP-Seq_THP-1_Human0.71871954
152TCF4_22108803_ChIP-Seq_LS180_Human0.71698839
153CSB_26484114_Chip-Seq_FIBROBLAST_Human0.71589710
154UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.70795896
155SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.70677455
156BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.69965428
157IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.69557428
158KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.68684383
159P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.67919258
160PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.67316683
161GATA6_21074721_ChIP-Seq_CACO-2_Human0.66823107
162* SA1_27219007_Chip-Seq_ERYTHROID_Human0.66315782
163CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.66150667
164SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.65832439
165AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.65229753
166SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.64925855
167RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.64876524

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier6.65129169
2MP0003941_abnormal_skin_development5.62222054
3MP0010234_abnormal_vibrissa_follicle5.56011538
4MP0005275_abnormal_skin_tensile4.18382847
5MP0005671_abnormal_response_to4.01718274
6MP0005501_abnormal_skin_physiology3.98894818
7MP0004782_abnormal_surfactant_physiolog3.69930149
8MP0003763_abnormal_thymus_physiology3.29785165
9MP0004381_abnormal_hair_follicle3.25395345
10MP0010678_abnormal_skin_adnexa3.22349134
11MP0000383_abnormal_hair_follicle3.05506072
12MP0002098_abnormal_vibrissa_morphology2.92869291
13MP0001216_abnormal_epidermal_layer2.80842439
14MP0001873_stomach_inflammation2.71807564
15MP0004264_abnormal_extraembryonic_tissu2.66827584
16MP0000566_synostosis2.66510532
17MP0006082_CNS_inflammation2.61509029
18MP0002060_abnormal_skin_morphology2.59201168
19MP0003453_abnormal_keratinocyte_physiol2.55390084
20MP0000579_abnormal_nail_morphology2.42315816
21MP0010771_integument_phenotype2.40868559
22MP0005451_abnormal_body_composition2.35524337
23MP0003436_decreased_susceptibility_to2.35213832
24MP0001958_emphysema2.27702878
25MP0009379_abnormal_foot_pigmentation2.25488578
26MP0000647_abnormal_sebaceous_gland2.20088807
27MP0000681_abnormal_thyroid_gland2.16837861
28MP0003724_increased_susceptibility_to2.13823754
29MP0003878_abnormal_ear_physiology2.11326706
30MP0005377_hearing/vestibular/ear_phenot2.11326706
31MP0010368_abnormal_lymphatic_system2.09974440
32MP0004947_skin_inflammation2.09053462
33MP0009333_abnormal_splenocyte_physiolog2.07170357
34MP0005000_abnormal_immune_tolerance2.07123310
35MP0005025_abnormal_response_to2.03597355
36MP0000858_altered_metastatic_potential2.01314301
37MP0009785_altered_susceptibility_to2.01277361
38MP0000377_abnormal_hair_follicle1.97710395
39MP0003191_abnormal_cellular_cholesterol1.93889007
40MP0006054_spinal_hemorrhage1.89051089
41MP0002254_reproductive_system_inflammat1.86233915
42MP0003566_abnormal_cell_adhesion1.84455968
43MP0001835_abnormal_antigen_presentation1.84345354
44MP0001800_abnormal_humoral_immune1.76432929
45MP0002723_abnormal_immune_serum1.76205493
46MP0008995_early_reproductive_senescence1.74165835
47MP0004272_abnormal_basement_membrane1.74108382
48MP0002420_abnormal_adaptive_immunity1.73001040
49MP0000467_abnormal_esophagus_morphology1.71518849
50MP0002876_abnormal_thyroid_physiology1.71405983
51MP0001879_abnormal_lymphatic_vessel1.71082473
52MP0000685_abnormal_immune_system1.69962083
53MP0002933_joint_inflammation1.69868324
54MP0001819_abnormal_immune_cell1.69714404
55MP0008004_abnormal_stomach_pH1.62743811
56MP0008260_abnormal_autophagy1.60945546
57MP0002009_preneoplasia1.60905676
58MP0002148_abnormal_hypersensitivity_rea1.49820157
59MP0002452_abnormal_antigen_presenting1.49502058
60MP0002419_abnormal_innate_immunity1.48502656
61MP0010155_abnormal_intestine_physiology1.47199933
62MP0001533_abnormal_skeleton_physiology1.47054639
63MP0001542_abnormal_bone_strength1.46957946
64MP0001346_abnormal_lacrimal_gland1.44149559
65MP0002132_abnormal_respiratory_system1.39771213
66MP0000537_abnormal_urethra_morphology1.38666841
67MP0004185_abnormal_adipocyte_glucose1.37220995
68MP0003866_abnormal_defecation1.36928058
69MP0000427_abnormal_hair_cycle1.30941407
70MP0009931_abnormal_skin_appearance1.29242477
71MP0002405_respiratory_system_inflammati1.28890770
72MP0000762_abnormal_tongue_morphology1.28799914
73MP0001191_abnormal_skin_condition1.26081531
74MP0005464_abnormal_platelet_physiology1.26079817
75MP0000750_abnormal_muscle_regeneration1.26063485
76MP0003705_abnormal_hypodermis_morpholog1.25941881
77MP0010352_gastrointestinal_tract_polyps1.25177620
78MP0001845_abnormal_inflammatory_respons1.23153153
79MP0000716_abnormal_immune_system1.21949801
80MP0009384_cardiac_valve_regurgitation1.19633093
81MP0003448_altered_tumor_morphology1.17571398
82MP0003183_abnormal_peptide_metabolism1.15471491
83MP0001177_atelectasis1.13561399
84MP0005058_abnormal_lysosome_morphology1.13229361
85MP0002398_abnormal_bone_marrow1.09201042
86MP0005388_respiratory_system_phenotype1.08128075
87MP0002133_abnormal_respiratory_system1.08128075
88MP0000367_abnormal_coat/_hair1.06630841
89MP0002295_abnormal_pulmonary_circulatio1.02091709
90MP0002277_abnormal_respiratory_mucosa1.00497222
91MP0009780_abnormal_chondrocyte_physiolo0.98916028
92MP0002722_abnormal_immune_system0.96878806
93MP0002429_abnormal_blood_cell0.95151532
94MP0000703_abnormal_thymus_morphology0.93151351
95MP0005083_abnormal_biliary_tract0.91209437
96MP0003045_fibrosis0.90931670
97MP0000013_abnormal_adipose_tissue0.89933644
98MP0005023_abnormal_wound_healing0.89679246
99MP0001851_eye_inflammation0.89459766
100MP0005623_abnormal_meninges_morphology0.89217305
101MP0002136_abnormal_kidney_physiology0.88644186
102MP0000689_abnormal_spleen_morphology0.85825440
103MP0005166_decreased_susceptibility_to0.85714124
104MP0010030_abnormal_orbit_morphology0.85251307
105MP0003075_altered_response_to0.83778167
106MP0000516_abnormal_urinary_system0.83468728
107MP0005367_renal/urinary_system_phenotyp0.83468728
108MP0001243_abnormal_dermal_layer0.83337340
109MP0002234_abnormal_pharynx_morphology0.82586904
110MP0008469_abnormal_protein_level0.80449514
111MP0005390_skeleton_phenotype0.78370015
112MP0000465_gastrointestinal_hemorrhage0.77216504
113MP0001340_abnormal_eyelid_morphology0.74240527
114MP0004742_abnormal_vestibular_system0.72451072
115MP0009643_abnormal_urine_homeostasis0.72340740
116MP0003950_abnormal_plasma_membrane0.69067546
117MP0002998_abnormal_bone_remodeling0.68407404
118MP0004883_abnormal_blood_vessel0.68260060
119MP0001784_abnormal_fluid_regulation0.67861721
120MP0002019_abnormal_tumor_incidence0.66410093
121MP0001348_abnormal_lacrimal_gland0.65560491
122MP0004043_abnormal_pH_regulation0.65532763
123MP0002138_abnormal_hepatobiliary_system0.65396289
124MP0005408_hypopigmentation0.64502770
125MP0000627_abnormal_mammary_gland0.64024857
126MP0004019_abnormal_vitamin_homeostasis0.62136595
127MP0002166_altered_tumor_susceptibility0.60326033
128MP0004084_abnormal_cardiac_muscle0.58023071
129MP0003828_pulmonary_edema0.56466722
130MP0008875_abnormal_xenobiotic_pharmacok0.55478473
131MP0005165_increased_susceptibility_to0.55422850
132MP0003638_abnormal_response/metabolism_0.52058964
133MP0002282_abnormal_trachea_morphology0.51675046
134MP0002135_abnormal_kidney_morphology0.51589301
135MP0003786_premature_aging0.50884885
136MP0001756_abnormal_urination0.50264703
137MP0009053_abnormal_anal_canal0.49856626
138MP0005595_abnormal_vascular_smooth0.49176539
139MP0005508_abnormal_skeleton_morphology0.48497460
140MP0005187_abnormal_penis_morphology0.48135118
141MP0003091_abnormal_cell_migration0.47212992
142MP0000470_abnormal_stomach_morphology0.46277976
143MP0003315_abnormal_perineum_morphology0.45941807
144MP0001666_abnormal_nutrient_absorption0.45709416
145MP0002006_tumorigenesis0.45565681
146MP0005164_abnormal_response_to0.43377769
147MP0001790_abnormal_immune_system0.42166876
148MP0005387_immune_system_phenotype0.42166876
149MP0005075_abnormal_melanosome_morpholog0.39831572
150MP0003115_abnormal_respiratory_system0.39187801
151MP0001984_abnormal_olfaction0.39004810
152MP0005076_abnormal_cell_differentiation0.38991628
153MP0001765_abnormal_ion_homeostasis0.38564177
154MP0000767_abnormal_smooth_muscle0.37585978

Predicted human phenotypes

RankGene SetZ-score
1Congenital nonbullous ichthyosiform erythroderma (HP:0007479)6.35787846
2Congenital ichthyosiform erythroderma (HP:0007431)6.21370360
3Onycholysis (HP:0001806)6.03843758
4Hypotrichosis (HP:0001006)5.37862151
5Parakeratosis (HP:0001036)5.00256175
6Fragile nails (HP:0001808)4.99164128
7Woolly hair (HP:0002224)4.98109055
8Increased IgE level (HP:0003212)4.94650149
9Right ventricular cardiomyopathy (HP:0011663)4.68022935
10Interstitial pulmonary disease (HP:0006530)4.64332262
11Corneal erosion (HP:0200020)4.52681937
12Plantar hyperkeratosis (HP:0007556)4.40486371
13Increased IgM level (HP:0003496)4.36695452
14Lip pit (HP:0100267)4.34782926
15Abnormality of macrophages (HP:0004311)4.26144778
16T lymphocytopenia (HP:0005403)4.24633317
17Hyperactive renin-angiotensin system (HP:0000841)4.18494199
18Chronic bronchitis (HP:0004469)4.09204130
19Erythema (HP:0010783)3.85170298
20Abnormality of T cell number (HP:0011839)3.81565684
21Erythroderma (HP:0001019)3.77113364
22Oral leukoplakia (HP:0002745)3.66093525
23Mesangial abnormality (HP:0001966)3.65937266
24Palmoplantar hyperkeratosis (HP:0000972)3.51978155
25IgG deficiency (HP:0004315)3.38753465
26Hypergammaglobulinemia (HP:0010702)3.38350333
27Goiter (HP:0000853)3.33820577
28Elevated erythrocyte sedimentation rate (HP:0003565)3.29796285
29Palmar hyperkeratosis (HP:0010765)3.28988368
30Focal segmental glomerulosclerosis (HP:0000097)3.27264930
31Milia (HP:0001056)3.24418324
32Retinal dysplasia (HP:0007973)3.19607244
33Abnormality of nail color (HP:0100643)3.17839563
34Aplastic anemia (HP:0001915)3.16301786
35Ectropion (HP:0000656)3.10794954
36Acanthosis nigricans (HP:0000956)3.05537493
37Abnormal blistering of the skin (HP:0008066)3.02995824
38Reticulocytopenia (HP:0001896)3.02990429
39Popliteal pterygium (HP:0009756)3.02481016
40Glomerulosclerosis (HP:0000096)3.01408117
41Abnormal albumin level (HP:0012116)2.94935223
42Hypoalbuminemia (HP:0003073)2.94935223
43Eczematoid dermatitis (HP:0000976)2.93638234
44Fatigue (HP:0012378)2.91319361
45Abnormal hair laboratory examination (HP:0003328)2.89798751
46Renal salt wasting (HP:0000127)2.85790833
47Tubulointerstitial fibrosis (HP:0005576)2.82600741
48Pruritus (HP:0000989)2.81181430
49Nail dystrophy (HP:0008404)2.77848627
50Myositis (HP:0100614)2.77713472
51Gangrene (HP:0100758)2.76818473
52Natal tooth (HP:0000695)2.76388424
53Curly hair (HP:0002212)2.76364962
54Dehydration (HP:0001944)2.72660846
55Advanced eruption of teeth (HP:0006288)2.70178160
56Gastrointestinal infarctions (HP:0005244)2.70059315
57Abnormality of glycolipid metabolism (HP:0010969)2.68712859
58Abnormality of liposaccharide metabolism (HP:0010968)2.68712859
59Abnormality of glycosphingolipid metabolism (HP:0004343)2.68712859
60Retinal atrophy (HP:0001105)2.68520519
61Nephritis (HP:0000123)2.68346160
62Sparse eyelashes (HP:0000653)2.67383229
63Abnormal hemoglobin (HP:0011902)2.66086311
64Abnormality of the axillary hair (HP:0100134)2.63940647
65Abnormality of secondary sexual hair (HP:0009888)2.63940647
66Pili torti (HP:0003777)2.63871940
67Hyporeflexia of lower limbs (HP:0002600)2.59846121
68Cerebellar dysplasia (HP:0007033)2.57915475
69Sparse scalp hair (HP:0002209)2.57722739
70Hypohidrosis (HP:0000966)2.55685625
71Small epiphyses (HP:0010585)2.54459808
72Difficulty climbing stairs (HP:0003551)2.53997964
73Granulocytopenia (HP:0001913)2.53563601
74Tubular atrophy (HP:0000092)2.51009616
75Concave nail (HP:0001598)2.49807149
76Decreased electroretinogram (ERG) amplitude (HP:0000654)2.49609644
77Eosinophilia (HP:0001880)2.48908926
78Pustule (HP:0200039)2.48630835
79Hypoplastic labia majora (HP:0000059)2.45736873
80Abnormality of cells of the erythroid lineage (HP:0012130)2.45727818
81Hyperkalemia (HP:0002153)2.44800693
82B lymphocytopenia (HP:0010976)2.42439954
83Joint swelling (HP:0001386)2.42200392
84Abnormality of eosinophils (HP:0001879)2.41928897
85Abnormality of B cell number (HP:0010975)2.41874301
86Palmoplantar keratoderma (HP:0000982)2.40728169
87Encephalitis (HP:0002383)2.39955947
88Atrophic scars (HP:0001075)2.37986184
89Neonatal respiratory distress (HP:0002643)2.37052557
90Congenital, generalized hypertrichosis (HP:0004540)2.35482886
91Aplasia/Hypoplasia of the abdominal wall musculature (HP:0010318)2.33483567
92Pterygium (HP:0001059)2.30478952
93Type II lissencephaly (HP:0007260)2.30026193
94Absent eyebrow (HP:0002223)2.29185313
95Thyroid-stimulating hormone excess (HP:0002925)2.27613395
96Double outlet right ventricle (HP:0001719)2.27440592
97Congenital malformation of the right heart (HP:0011723)2.27440592
98Abnormality of the fetal cardiovascular system (HP:0010948)2.26321269
99Abnormal umbilical cord blood vessels (HP:0011403)2.26321269
100Single umbilical artery (HP:0001195)2.26321269
101Hypoproteinemia (HP:0003075)2.24316733
102Distal lower limb muscle weakness (HP:0009053)2.23257410
103Entropion (HP:0000621)2.22078715
104Abnormality of the labia majora (HP:0012881)2.20967155
105Buphthalmos (HP:0000557)2.20781929
106Hypokalemic alkalosis (HP:0001949)2.19176523
107Abnormality of T cells (HP:0002843)2.16922668
108Abnormality of the salivary glands (HP:0010286)2.16529624
109Abnormality of chloride homeostasis (HP:0011422)2.15237023
110Abnormality of the distal phalanges of the toes (HP:0010182)2.15120950
111Abnormality of the gastric mucosa (HP:0004295)2.15072334
112Partial duplication of thumb phalanx (HP:0009944)2.14683644
113Orchitis (HP:0100796)2.14152313
114Flat capital femoral epiphysis (HP:0003370)2.13350171
115Hypoparathyroidism (HP:0000829)2.11902266
116Stomatitis (HP:0010280)2.11702118
117Blepharitis (HP:0000498)2.10800521
118Reduced subcutaneous adipose tissue (HP:0003758)2.07010297
119Amelogenesis imperfecta (HP:0000705)2.06835799
120Ventricular tachycardia (HP:0004756)2.06635551
121Hypoplasia of the thymus (HP:0000778)2.06343581
122Obstructive lung disease (HP:0006536)2.06338061
123Chronic obstructive pulmonary disease (HP:0006510)2.06338061
124Autoimmune hemolytic anemia (HP:0001890)2.03998466
125Meningitis (HP:0001287)2.03817027
126Aplasia involving bones of the extremities (HP:0009825)2.03727723
127Aplasia involving bones of the upper limbs (HP:0009823)2.03727723
128Aplasia of the phalanges of the hand (HP:0009802)2.03727723
129Recurrent bacterial skin infections (HP:0005406)2.00664434
130Increased serum ferritin (HP:0003281)2.00557522
131Abnormality of the nasal mucosa (HP:0000433)1.99479441
132Abnormal number of erythroid precursors (HP:0012131)1.99249501
133Leukocytosis (HP:0001974)1.98945023
134Stenosis of the external auditory canal (HP:0000402)1.98604630
135Thick nail (HP:0001805)1.98082455
136Down-sloping shoulders (HP:0200021)1.98058295
137Hyperthyroidism (HP:0000836)1.97480550
138Labial hypoplasia (HP:0000066)1.97087828
139Anhidrosis (HP:0000970)1.96292110
140Hematochezia (HP:0002573)1.95575327
141Hypoplasia of the pons (HP:0012110)1.95455368
142Mediastinal lymphadenopathy (HP:0100721)1.95097657
143Urticaria (HP:0001025)1.94980807
144Brittle hair (HP:0002299)1.93726397
145Respiratory distress (HP:0002098)1.92824292
146Acute hepatic failure (HP:0006554)1.91908867
147Alopecia of scalp (HP:0002293)1.91847931
148Hypoplasia of dental enamel (HP:0006297)1.89465744
149Lymphopenia (HP:0001888)1.88842868
150Oligodontia (HP:0000677)1.87786564
151Stage 5 chronic kidney disease (HP:0003774)1.87671971
152Recurrent abscess formation (HP:0002722)1.87553306
153Bifid scrotum (HP:0000048)1.87388998
154Synostosis involving the elbow (HP:0003938)1.87269262
155Humeroradial synostosis (HP:0003041)1.87269262
156Delayed epiphyseal ossification (HP:0002663)1.87209582
157Glomerulonephritis (HP:0000099)1.86434280
158Conical tooth (HP:0000698)1.85252044
159Severe combined immunodeficiency (HP:0004430)1.85190818
160Slow saccadic eye movements (HP:0000514)1.84805175
161Severe Myopia (HP:0011003)1.84691245
162Recurrent fungal infections (HP:0002841)1.84521886
163Verrucae (HP:0200043)1.83968986
164Papilloma (HP:0012740)1.83968986
165Macrocytic anemia (HP:0001972)1.83280721
166Hyperaldosteronism (HP:0000859)1.82979404
167Vertebral compression fractures (HP:0002953)1.82374394
168Abnormality of the pericardium (HP:0001697)1.79006075
169Skin rash (HP:0000988)1.77625459
170Severe visual impairment (HP:0001141)1.77183311
171Abnormality of cells of the lymphoid lineage (HP:0012140)1.73926816

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K34.47600101
2TESK24.19855634
3MST44.12236858
4MAP4K13.96028517
5EPHB23.87031774
6MST1R3.81014564
7MAPKAPK32.95671870
8TGFBR22.92406666
9FER2.85875336
10TESK12.80500243
11TXK2.73375187
12EPHA22.61544393
13GRK62.59375539
14MAP3K22.57662709
15TIE12.55685680
16MUSK2.50952148
17LRRK22.50448806
18TAOK32.33239933
19STK242.32886750
20FGFR22.11135664
21RPS6KB22.07180375
22STK102.03541647
23GRK11.84426351
24FGFR41.68716753
25LIMK11.67758400
26ERBB31.60278080
27TRPM71.54192863
28PRKD21.53480380
29MAP3K111.49234675
30MARK31.46920988
31EPHB11.40913439
32MET1.36615558
33MAP2K31.35664050
34PIM21.34706387
35IRAK41.33556218
36SCYL21.29616900
37LATS11.28899111
38ERN11.25437449
39STK381.19773977
40RIPK11.18136968
41CDK81.18106530
42BTK1.14902024
43EPHA31.13347279
44PTK61.11207734
45VRK21.10907271
46IRAK31.10605646
47RIPK41.09634713
48ILK1.09421191
49PAK41.04776058
50WNK41.04029092
51TAOK10.97980158
52MAPK150.97180364
53TNK20.96151366
54GRK70.95839508
55DAPK20.95804204
56FGFR30.89574569
57NME20.89388908
58BCKDK0.87693050
59CSF1R0.84445147
60MAP3K120.84400197
61MAP3K140.83144351
62PKN20.82770300
63ZAP700.80633077
64MAP2K20.80114830
65SYK0.79664272
66MYLK0.79373183
67MAP2K60.79242091
68LCK0.77051784
69TRIB30.76125773
70IKBKE0.72933503
71CDK60.68401902
72RPS6KA40.67424794
73TLK10.67377240
74BCR0.67106623
75PTK2B0.66755868
76DYRK1B0.66287210
77PRKCH0.66127475
78PIM10.66057858
79PRKCE0.64628200
80TGFBR10.62814289
81MAPKAPK20.62573639
82HCK0.61485634
83MAP3K70.61233746
84JAK30.61172488
85MAP3K10.60399091
86NEK60.60013030
87MAP3K60.58924399
88ITK0.57864217
89GRK50.57774565
90PRKD10.57252593
91MAP2K10.56956755
92ROCK10.56476179
93PRKCI0.56087330
94PDGFRB0.55433379
95PTK20.55272015
96OXSR10.54878484
97LYN0.52701177
98NEK90.51984122
99STK390.51898155
100TTN0.51658405
101TYK20.51483765
102PIK3CG0.48959143
103PRPF4B0.47314727
104JAK10.46981391
105TAOK20.46225221
106HIPK20.46010263
107GSK3A0.45701427
108BLK0.44112096
109PDPK10.43988398
110SIK30.43706079
111CSK0.43488804
112PDK20.43232072
113PDK10.42840657
114FES0.42503105
115FYN0.40889956
116ABL10.39655888
117CDK30.39563529
118CHUK0.39265212
119CDC42BPA0.39195343
120KDR0.38527836
121STK38L0.38382470
122CDK40.36717934
123MELK0.35165337
124DAPK10.34876038
125LMTK20.34440895
126IKBKB0.32523968
127EIF2AK20.32334759
128PRKCD0.32207518
129AKT30.31952258
130PRKCQ0.31062719
131NME10.30182663
132EGFR0.29554984
133MAPKAPK50.29395658
134MOS0.29254524
135FGFR10.28623709
136ERBB20.27168735
137MAPK70.27035649
138ADRBK10.26866082
139BMPR1B0.26317024
140SIK10.26307688
141TEC0.25826402
142CAMK10.24865918
143SGK20.24700044
144TBK10.23998180
145STK30.22675084
146ROCK20.21163439
147JAK20.20785091

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.23438052
2Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.65957050
3Sphingolipid metabolism_Homo sapiens_hsa006003.59007165
4Cyanoamino acid metabolism_Homo sapiens_hsa004603.57517006
5Autoimmune thyroid disease_Homo sapiens_hsa053203.53838558
6Ribosome_Homo sapiens_hsa030103.50218636
7Graft-versus-host disease_Homo sapiens_hsa053323.02984123
8Antigen processing and presentation_Homo sapiens_hsa046122.98664103
9ECM-receptor interaction_Homo sapiens_hsa045122.48070510
10Arachidonic acid metabolism_Homo sapiens_hsa005902.45711470
11Tight junction_Homo sapiens_hsa045302.40425661
12Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.27468323
13Hematopoietic cell lineage_Homo sapiens_hsa046402.26642836
14T cell receptor signaling pathway_Homo sapiens_hsa046602.25611090
15Histidine metabolism_Homo sapiens_hsa003402.21439658
16Allograft rejection_Homo sapiens_hsa053302.16150800
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.05506312
18Fatty acid elongation_Homo sapiens_hsa000621.98431073
19Adherens junction_Homo sapiens_hsa045201.97376116
20Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.95457645
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.95415985
22Linoleic acid metabolism_Homo sapiens_hsa005911.92526505
23alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.86061522
24Leukocyte transendothelial migration_Homo sapiens_hsa046701.84316486
25NF-kappa B signaling pathway_Homo sapiens_hsa040641.80568068
26Osteoclast differentiation_Homo sapiens_hsa043801.77638715
27Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.77184687
28Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.76800850
29Proteasome_Homo sapiens_hsa030501.69012902
30Hippo signaling pathway_Homo sapiens_hsa043901.66059815
31Retinol metabolism_Homo sapiens_hsa008301.63042848
32Phenylalanine metabolism_Homo sapiens_hsa003601.61770493
33Bladder cancer_Homo sapiens_hsa052191.59628203
34Toll-like receptor signaling pathway_Homo sapiens_hsa046201.58533508
35Basal cell carcinoma_Homo sapiens_hsa052171.56072330
36Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.55368619
37Leishmaniasis_Homo sapiens_hsa051401.54641106
38Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.52418904
39Chemical carcinogenesis_Homo sapiens_hsa052041.51797917
40AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.51689096
41Measles_Homo sapiens_hsa051621.51283697
42Malaria_Homo sapiens_hsa051441.50154870
43Axon guidance_Homo sapiens_hsa043601.49919770
44Viral myocarditis_Homo sapiens_hsa054161.49714375
45Shigellosis_Homo sapiens_hsa051311.49212778
46Sulfur relay system_Homo sapiens_hsa041221.49016119
47ABC transporters_Homo sapiens_hsa020101.43038551
48Amoebiasis_Homo sapiens_hsa051461.42992027
49NOD-like receptor signaling pathway_Homo sapiens_hsa046211.38890074
50Small cell lung cancer_Homo sapiens_hsa052221.38071305
51Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.36018313
52Mineral absorption_Homo sapiens_hsa049781.35805337
53Type I diabetes mellitus_Homo sapiens_hsa049401.35192985
54VEGF signaling pathway_Homo sapiens_hsa043701.34186641
55Glutathione metabolism_Homo sapiens_hsa004801.32292868
56Ether lipid metabolism_Homo sapiens_hsa005651.23354391
57TNF signaling pathway_Homo sapiens_hsa046681.23332874
58Proteoglycans in cancer_Homo sapiens_hsa052051.21629392
59RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.20920233
60Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.19185710
61Renin-angiotensin system_Homo sapiens_hsa046141.18057496
62Thyroid hormone synthesis_Homo sapiens_hsa049181.09842440
63Caffeine metabolism_Homo sapiens_hsa002321.09011467
64Glycosaminoglycan degradation_Homo sapiens_hsa005311.06921027
65Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.06578598
66Hepatitis C_Homo sapiens_hsa051601.06445041
67B cell receptor signaling pathway_Homo sapiens_hsa046621.03521897
68Focal adhesion_Homo sapiens_hsa045101.02276503
69Acute myeloid leukemia_Homo sapiens_hsa052211.00595918
70Collecting duct acid secretion_Homo sapiens_hsa049660.99548836
71Pentose phosphate pathway_Homo sapiens_hsa000300.95493945
72Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.93360644
73Chemokine signaling pathway_Homo sapiens_hsa040620.91836820
74Tyrosine metabolism_Homo sapiens_hsa003500.91408854
75Herpes simplex infection_Homo sapiens_hsa051680.88898395
76Sphingolipid signaling pathway_Homo sapiens_hsa040710.87542985
77Jak-STAT signaling pathway_Homo sapiens_hsa046300.87155884
78Primary bile acid biosynthesis_Homo sapiens_hsa001200.87095425
79Melanogenesis_Homo sapiens_hsa049160.85546392
80Hedgehog signaling pathway_Homo sapiens_hsa043400.85398193
81Pancreatic cancer_Homo sapiens_hsa052120.83783308
82SNARE interactions in vesicular transport_Homo sapiens_hsa041300.82194836
83Rap1 signaling pathway_Homo sapiens_hsa040150.82053321
84Protein digestion and absorption_Homo sapiens_hsa049740.81232686
85Oxidative phosphorylation_Homo sapiens_hsa001900.80046935
86Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.78949409
87TGF-beta signaling pathway_Homo sapiens_hsa043500.78782463
88Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.78225003
89Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.78028323
90Lysosome_Homo sapiens_hsa041420.76369002
91Tuberculosis_Homo sapiens_hsa051520.75703908
92Endocytosis_Homo sapiens_hsa041440.75377629
93beta-Alanine metabolism_Homo sapiens_hsa004100.73561258
94Vibrio cholerae infection_Homo sapiens_hsa051100.72498312
95Platelet activation_Homo sapiens_hsa046110.72128819
96Renin secretion_Homo sapiens_hsa049240.71842600
97Influenza A_Homo sapiens_hsa051640.70166614
98Pertussis_Homo sapiens_hsa051330.67985786
99Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.67850566
100Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.66641363
101Toxoplasmosis_Homo sapiens_hsa051450.65637090
102Pathways in cancer_Homo sapiens_hsa052000.63979630
103Complement and coagulation cascades_Homo sapiens_hsa046100.63004436
104Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.61990409
105Staphylococcus aureus infection_Homo sapiens_hsa051500.59030660
106N-Glycan biosynthesis_Homo sapiens_hsa005100.58977861
107Glycerophospholipid metabolism_Homo sapiens_hsa005640.58916193
108Phagosome_Homo sapiens_hsa041450.57553268
109HTLV-I infection_Homo sapiens_hsa051660.56914186
110Vascular smooth muscle contraction_Homo sapiens_hsa042700.56680422
111Regulation of actin cytoskeleton_Homo sapiens_hsa048100.55921553
112Legionellosis_Homo sapiens_hsa051340.53713367
113Ras signaling pathway_Homo sapiens_hsa040140.53238709
114Taste transduction_Homo sapiens_hsa047420.51427647
115Adipocytokine signaling pathway_Homo sapiens_hsa049200.51319613
116MicroRNAs in cancer_Homo sapiens_hsa052060.51263790
117Pancreatic secretion_Homo sapiens_hsa049720.50138303
118Non-small cell lung cancer_Homo sapiens_hsa052230.49205656
119p53 signaling pathway_Homo sapiens_hsa041150.48910483
120Sulfur metabolism_Homo sapiens_hsa009200.45822792
121Intestinal immune network for IgA production_Homo sapiens_hsa046720.44845634
122Drug metabolism - other enzymes_Homo sapiens_hsa009830.43691988
123Circadian rhythm_Homo sapiens_hsa047100.42901348
124Fatty acid biosynthesis_Homo sapiens_hsa000610.42583534
125Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.41864907
126Other glycan degradation_Homo sapiens_hsa005110.41663391
127Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.41171607
128Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.40932051
129Rheumatoid arthritis_Homo sapiens_hsa053230.40808264
130Epstein-Barr virus infection_Homo sapiens_hsa051690.40707610
131Galactose metabolism_Homo sapiens_hsa000520.40007889
132Fat digestion and absorption_Homo sapiens_hsa049750.39959876
133Gastric acid secretion_Homo sapiens_hsa049710.39954538
134PI3K-Akt signaling pathway_Homo sapiens_hsa041510.39418982
135Wnt signaling pathway_Homo sapiens_hsa043100.38934445
136Asthma_Homo sapiens_hsa053100.38655114
137Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.38501150
138Fatty acid degradation_Homo sapiens_hsa000710.38366943
139Steroid hormone biosynthesis_Homo sapiens_hsa001400.38059017
140Regulation of autophagy_Homo sapiens_hsa041400.37576080
141Insulin resistance_Homo sapiens_hsa049310.35892043
142Renal cell carcinoma_Homo sapiens_hsa052110.34821703
143Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.34651241
144Alzheimers disease_Homo sapiens_hsa050100.34227830
145GnRH signaling pathway_Homo sapiens_hsa049120.33637825
146Prostate cancer_Homo sapiens_hsa052150.33424054
147Vitamin digestion and absorption_Homo sapiens_hsa049770.33186780
148Notch signaling pathway_Homo sapiens_hsa043300.32952527
149Ovarian steroidogenesis_Homo sapiens_hsa049130.31413827
150Peroxisome_Homo sapiens_hsa041460.30600846
151Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.29839437
152Thyroid cancer_Homo sapiens_hsa052160.29499901
153Apoptosis_Homo sapiens_hsa042100.27727032
154Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.27584104
155Salmonella infection_Homo sapiens_hsa051320.26769635
156Hepatitis B_Homo sapiens_hsa051610.25392817

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »