CLIC4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 4 (CLIC4) protein, encoded by the CLIC4 gene, is a member of the p64 family; the gene is expressed in many tissues and exhibits a intracellular vesicular pattern in Panc-1 cells (pancreatic cancer cells). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1virion attachment to host cell (GO:0019062)4.69251922
2adhesion of symbiont to host cell (GO:0044650)4.69251922
3collagen fibril organization (GO:0030199)4.38256459
4paraxial mesoderm development (GO:0048339)4.30304658
5chondrocyte proliferation (GO:0035988)4.25162616
6low-density lipoprotein particle clearance (GO:0034383)4.17667421
7hemidesmosome assembly (GO:0031581)4.07535775
8skin morphogenesis (GO:0043589)4.03426457
9adhesion of symbiont to host (GO:0044406)4.01531547
10cell adhesion mediated by integrin (GO:0033627)3.94434879
11COPI coating of Golgi vesicle (GO:0048205)3.93925771
12Golgi transport vesicle coating (GO:0048200)3.93925771
13protein localization to endosome (GO:0036010)3.92033198
14modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.91380913
15positive regulation by organism of defense response of other organism involved in symbiotic interact3.91380913
16modulation by symbiont of host immune response (GO:0052553)3.91380913
17positive regulation by symbiont of host defense response (GO:0052509)3.91380913
18modulation by symbiont of host defense response (GO:0052031)3.91380913
19modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.91380913
20cell-substrate junction assembly (GO:0007044)3.87732578
21growth hormone receptor signaling pathway (GO:0060396)3.66105283
22protein heterotrimerization (GO:0070208)3.65632722
23central nervous system myelination (GO:0022010)3.61666813
24axon ensheathment in central nervous system (GO:0032291)3.61666813
25regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.60459014
26response to lipoprotein particle (GO:0055094)3.57787377
27maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.52083170
28wound healing, spreading of epidermal cells (GO:0035313)3.46842975
29cell migration involved in sprouting angiogenesis (GO:0002042)3.45596367
30sequestering of extracellular ligand from receptor (GO:0035581)3.45334077
31cellular response to interferon-alpha (GO:0035457)3.44572858
32substrate-dependent cell migration (GO:0006929)3.43968913
33protein retention in ER lumen (GO:0006621)3.43237168
34membrane raft organization (GO:0031579)3.40103951
35negative regulation of chondrocyte differentiation (GO:0032331)3.39703532
36neutrophil activation involved in immune response (GO:0002283)3.39601872
37positive regulation of macrophage cytokine production (GO:0060907)3.32839711
38regulation of dendritic cell antigen processing and presentation (GO:0002604)3.32754129
39creatine metabolic process (GO:0006600)3.29961858
40positive regulation of interferon-alpha production (GO:0032727)3.28423052
41adherens junction assembly (GO:0034333)3.27407470
42kidney mesenchyme development (GO:0072074)3.25768555
43glomerular filtration (GO:0003094)3.25694651
44stress fiber assembly (GO:0043149)3.22419793
45hippo signaling (GO:0035329)3.22070355
46substrate adhesion-dependent cell spreading (GO:0034446)3.21899568
47wound healing, spreading of cells (GO:0044319)3.20589747
48barbed-end actin filament capping (GO:0051016)3.19246006
49collagen metabolic process (GO:0032963)3.18986193
50extracellular fibril organization (GO:0043206)3.18418535
51positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.18361881
52renal filtration (GO:0097205)3.16819897
53epithelial cell-cell adhesion (GO:0090136)3.16125724
54cortical actin cytoskeleton organization (GO:0030866)3.14096538
55cell-substrate adherens junction assembly (GO:0007045)3.14061106
56focal adhesion assembly (GO:0048041)3.14061106
57regulation of interferon-alpha production (GO:0032647)3.14034234
58planar cell polarity pathway involved in neural tube closure (GO:0090179)3.13753528
59cellular response to growth hormone stimulus (GO:0071378)3.13492215
60ensheathment of neurons (GO:0007272)3.12982576
61axon ensheathment (GO:0008366)3.12982576
62regulation of transforming growth factor beta2 production (GO:0032909)3.12653554
63cell migration involved in heart development (GO:0060973)3.11008639
64positive regulation of endothelial cell apoptotic process (GO:2000353)3.08737204
65bone trabecula formation (GO:0060346)3.07515667
66myelination (GO:0042552)3.03259701
67extracellular matrix assembly (GO:0085029)3.02761425
68positive regulation of blood vessel endothelial cell migration (GO:0043536)3.00449718
69response to muramyl dipeptide (GO:0032495)2.99688310
70collagen catabolic process (GO:0030574)2.96738107
71cellular response to vitamin (GO:0071295)2.96670733
72regulation of T-helper 1 cell differentiation (GO:0045625)2.96341457
73regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.95890059
74regulation of cholesterol storage (GO:0010885)2.95516095
75vascular endothelial growth factor signaling pathway (GO:0038084)2.95272897
76multicellular organismal macromolecule metabolic process (GO:0044259)2.93467627
77platelet-derived growth factor receptor signaling pathway (GO:0048008)2.93244139
78apoptotic cell clearance (GO:0043277)2.93026665
79establishment of endothelial barrier (GO:0061028)2.90707752
80positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.90133121
81dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.89996732
82positive regulation of p38MAPK cascade (GO:1900745)2.89725325
83positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.89573155
84heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.89384482
85regulation of macrophage cytokine production (GO:0010935)2.89252035
86metanephric mesenchyme development (GO:0072075)2.88924628
87extracellular matrix disassembly (GO:0022617)2.88900614
88peptidyl-proline hydroxylation (GO:0019511)2.86312827
89regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.86219322
90regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.84419546
91interleukin-6-mediated signaling pathway (GO:0070102)2.82986496
92type B pancreatic cell proliferation (GO:0044342)2.82448140
93regulation of membrane protein ectodomain proteolysis (GO:0051043)2.81451937
94notochord development (GO:0030903)2.81149900
95ventricular cardiac muscle cell development (GO:0055015)2.79181182
96regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.78138123
97chondrocyte development (GO:0002063)2.78130268
98cellular response to vitamin D (GO:0071305)2.78024080
99lymphangiogenesis (GO:0001946)2.77339506
100glomerular visceral epithelial cell development (GO:0072015)2.77058414
101mesenchymal-epithelial cell signaling (GO:0060638)2.76994480
102regulation of interferon-beta biosynthetic process (GO:0045357)2.76095121
103Rap protein signal transduction (GO:0032486)2.74924968
104multicellular organismal metabolic process (GO:0044236)2.74792990
105cortical cytoskeleton organization (GO:0030865)2.74382251
106sprouting angiogenesis (GO:0002040)2.73828914
107fibril organization (GO:0097435)2.73758924
108regulation of cardioblast differentiation (GO:0051890)2.73726695
109positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.70486639
110actin filament depolymerization (GO:0030042)2.69538789
111negative regulation of smooth muscle cell migration (GO:0014912)2.69185934
112COPII vesicle coating (GO:0048208)2.67009768
113T-helper 1 type immune response (GO:0042088)2.66413372
114regulation of integrin-mediated signaling pathway (GO:2001044)2.66144826
115multicellular organismal catabolic process (GO:0044243)2.65297094
116semaphorin-plexin signaling pathway (GO:0071526)2.64765876
117positive regulation of toll-like receptor signaling pathway (GO:0034123)2.64553654
118regulation of early endosome to late endosome transport (GO:2000641)2.64318267
119regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.63703439
120NIK/NF-kappaB signaling (GO:0038061)2.63661036
121protein localization to cell surface (GO:0034394)2.63211352
122protein hydroxylation (GO:0018126)2.63069174
123myelin maintenance (GO:0043217)2.61914364
124macrophage activation involved in immune response (GO:0002281)2.61585177
125positive regulation of osteoblast proliferation (GO:0033690)2.61288912
126extracellular matrix organization (GO:0030198)2.60666153
127antigen processing and presentation of endogenous antigen (GO:0019883)2.60054936
128extracellular structure organization (GO:0043062)2.59627698
129* retina vasculature morphogenesis in camera-type eye (GO:0061299)2.57411591
130gap junction assembly (GO:0016264)2.57118265
131response to peptidoglycan (GO:0032494)2.56996968
132muscle cell migration (GO:0014812)2.56872408
133nuclear pore complex assembly (GO:0051292)2.56715400
134negative regulation of anoikis (GO:2000811)2.56161290
135vesicle coating (GO:0006901)2.54799083
136positive regulation of T cell cytokine production (GO:0002726)2.53773441
137ruffle organization (GO:0031529)2.52914035
138myeloid cell homeostasis (GO:0002262)2.52851182
139hypotonic response (GO:0006971)2.51981863
140regulation of mononuclear cell migration (GO:0071675)2.51507264
141branching involved in salivary gland morphogenesis (GO:0060445)2.51341413
142cellular protein complex localization (GO:0034629)2.50226466
143natural killer cell mediated cytotoxicity (GO:0042267)2.49127666
144natural killer cell mediated immunity (GO:0002228)2.49127666
145positive regulation of interleukin-17 production (GO:0032740)2.48944841
146cytoskeletal anchoring at plasma membrane (GO:0007016)2.48885717
147response to laminar fluid shear stress (GO:0034616)2.48677920
148regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.48449886
149blood vessel endothelial cell migration (GO:0043534)2.48169858
150lipopolysaccharide-mediated signaling pathway (GO:0031663)2.48079452
151positive regulation of natural killer cell differentiation (GO:0032825)2.47803662
152vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.47707935
153positive regulation of interleukin-12 production (GO:0032735)2.46741035
154positive regulation of SMAD protein import into nucleus (GO:0060391)2.46552752
155membrane protein ectodomain proteolysis (GO:0006509)2.45738985
156positive regulation of type 2 immune response (GO:0002830)2.45737870
157hyaluronan catabolic process (GO:0030214)2.45055820
158* endothelial cell morphogenesis (GO:0001886)2.43752440
159leukocyte migration involved in inflammatory response (GO:0002523)2.43731414
160regulation of integrin activation (GO:0033623)2.43409838
161basement membrane organization (GO:0071711)2.42811366
162axon extension involved in axon guidance (GO:0048846)2.41675535
163neuron projection extension involved in neuron projection guidance (GO:1902284)2.41675535
164mitotic cytokinesis (GO:0000281)2.40836554
165Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.40186077
166positive regulation of pseudopodium assembly (GO:0031274)2.38608783
167regulation of interleukin-12 biosynthetic process (GO:0045075)2.38438398
168antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.37794639
169antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.37794639
170venous blood vessel morphogenesis (GO:0048845)2.37167544
171regulation of podosome assembly (GO:0071801)2.36354561
172regulation of osteoblast proliferation (GO:0033688)2.35114588
173granulocyte activation (GO:0036230)2.34930989
174peptidyl-tyrosine autophosphorylation (GO:0038083)2.33694940
175antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.32925869
176heterotypic cell-cell adhesion (GO:0034113)2.32480112
177mesodermal cell differentiation (GO:0048333)2.32401110
178positive regulation of actin filament depolymerization (GO:0030836)2.30592482
179response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.30402973
180response to host immune response (GO:0052572)2.30402973
181JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.29774264
182positive regulation of lipid storage (GO:0010884)2.29156526
183endodermal cell differentiation (GO:0035987)2.28961274
184positive regulation of antigen processing and presentation (GO:0002579)2.27086786
185positive regulation of vasculogenesis (GO:2001214)2.26798732
186neutrophil activation (GO:0042119)2.25611596
187cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.24108937
188positive regulation of chemokine biosynthetic process (GO:0045080)2.23999409
189integrin-mediated signaling pathway (GO:0007229)2.23959640

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human3.99321436
2TRIM28_21343339_ChIP-Seq_HEK293_Human3.95258606
3IRF8_21731497_ChIP-ChIP_J774_Mouse3.86985148
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.57517481
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.47628909
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.33838469
7* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.91402033
8BP1_19119308_ChIP-ChIP_Hs578T_Human2.69733125
9* IRF8_27001747_Chip-Seq_BMDM_Mouse2.64177326
10STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.62079571
11Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.45824128
12AR_21909140_ChIP-Seq_LNCAP_Human2.45468438
13CLOCK_20551151_ChIP-Seq_293T_Human2.44325407
14IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.44126784
15RARG_19884340_ChIP-ChIP_MEFs_Mouse2.43979801
16TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.43690836
17SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.36129172
18NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.34716715
19* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.26224647
20E2F7_22180533_ChIP-Seq_HELA_Human2.25720026
21PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.17587103
22SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.14972215
23SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.10584708
24FOXM1_23109430_ChIP-Seq_U2OS_Human2.07914938
25FOXO3_23340844_ChIP-Seq_DLD1_Human2.07707267
26EGR1_19374776_ChIP-ChIP_THP-1_Human2.06090218
27WT1_19549856_ChIP-ChIP_CCG9911_Human2.05702934
28GATA2_21666600_ChIP-Seq_HMVEC_Human2.04776531
29TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.03964900
30POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.01765667
31* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse2.00712590
32ELK3_25401928_ChIP-Seq_HUVEC_Human1.87051492
33ESR2_21235772_ChIP-Seq_MCF-7_Human1.84067307
34* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.82288720
35* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.78613065
36* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.74456454
37ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.74080204
38PPAR_26484153_Chip-Seq_NCI-H1993_Human1.73464131
39GATA1_22025678_ChIP-Seq_K562_Human1.70101576
40SALL4_18804426_ChIP-ChIP_XEN_Mouse1.69661428
41EP300_21415370_ChIP-Seq_HL-1_Mouse1.68272843
42* CDX2_19796622_ChIP-Seq_MESCs_Mouse1.66713808
43ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.66061901
44CJUN_26792858_Chip-Seq_BT549_Human1.65499977
45NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.64552226
46VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.63689113
47* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.57230790
48* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.57214191
49HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.55791569
50VDR_24787735_ChIP-Seq_THP-1_Human1.55164569
51SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.54631412
52SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.54631412
53IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.53641158
54* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.52436489
55* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.52359095
56STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.51100024
57NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.50846064
58CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.50748523
59PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.50287482
60NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.48623290
61TP53_18474530_ChIP-ChIP_U2OS_Human1.47789597
62NRF2_20460467_ChIP-Seq_MEFs_Mouse1.46792369
63NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.46792369
64* TBX20_22080862_ChIP-Seq_HEART_Mouse1.46196364
65* TBX20_22328084_ChIP-Seq_HEART_Mouse1.46196364
66JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.45733151
67* SOX2_20726797_ChIP-Seq_SW620_Human1.45338273
68STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.45160010
69HIF1A_21447827_ChIP-Seq_MCF-7_Human1.45126468
70ZNF217_24962896_ChIP-Seq_MCF-7_Human1.42973723
71MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.42029191
72TCF3_18692474_ChIP-Seq_MEFs_Mouse1.42024447
73JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.40231439
74RBPJ_22232070_ChIP-Seq_NCS_Mouse1.39545475
75ESR1_21235772_ChIP-Seq_MCF-7_Human1.37124278
76* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.35228866
77SMAD_19615063_ChIP-ChIP_OVARY_Human1.31570773
78KDM2B_26808549_Chip-Seq_SUP-B15_Human1.31164463
79GATA1_19941826_ChIP-Seq_K562_Human1.29346114
80BRD4_27068464_Chip-Seq_AML-cells_Mouse1.28869969
81* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.28474047
82* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.27498212
83CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.26901602
84* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.25832206
85KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.24282216
86RUNX_20019798_ChIP-Seq_JUKART_Human1.24146001
87PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.22197462
88SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.21745687
89MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.20949796
90PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.20560209
91SPI1_23127762_ChIP-Seq_K562_Human1.18777098
92* UBF1/2_26484160_Chip-Seq_HMECs_Human1.18534488
93ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.17570807
94STAT4_19710469_ChIP-ChIP_TH1__Mouse1.17481903
95P63_26484246_Chip-Seq_KERATINOCYTES_Human1.16726730
96* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16698166
97SALL1_21062744_ChIP-ChIP_HESCs_Human1.14377468
98TP53_16413492_ChIP-PET_HCT116_Human1.13459284
99* RACK7_27058665_Chip-Seq_MCF-7_Human1.13151619
100NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.12675574
101VDR_24763502_ChIP-Seq_THP-1_Human1.11206062
102BRD4_25478319_ChIP-Seq_HGPS_Human1.10470069
103* KDM2B_26808549_Chip-Seq_DND41_Human1.10264444
104* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.10168597
105GATA4_21415370_ChIP-Seq_HL-1_Mouse1.09263429
106PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.08881132
107SOX17_20123909_ChIP-Seq_XEN_Mouse1.08671993
108THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.08638201
109SOX2_27498859_Chip-Seq_STOMACH_Mouse1.08420439
110SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.08030266
111ZNF263_19887448_ChIP-Seq_K562_Human1.07619213
112CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.07421104
113TP53_22127205_ChIP-Seq_IMR90_Human1.06708905
114* MAF_26560356_Chip-Seq_TH1_Human1.05904395
115ISL1_27105846_Chip-Seq_CPCs_Mouse1.05600784
116MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.04192329
117KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.02829388
118KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.02829388
119KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.02829388
120ZFP281_18757296_ChIP-ChIP_E14_Mouse1.02269025
121SOX9_24532713_ChIP-Seq_HFSC_Mouse1.00836312
122FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.99303042
123NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.99222556
124PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98999240
125PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.98612829
126SMC1_22415368_ChIP-Seq_MEFs_Mouse0.95371666
127TCF3_18692474_ChIP-Seq_MESCs_Mouse0.95051060
128PU_27001747_Chip-Seq_BMDM_Mouse0.94125148
129WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.93649655
130TP53_23651856_ChIP-Seq_MEFs_Mouse0.93473778
131RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93408846
132* EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.92877765
133UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.92816169
134* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.92366819
135SA1_22415368_ChIP-Seq_MEFs_Mouse0.92362136
136PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92354811
137NFIB_24661679_ChIP-Seq_LUNG_Mouse0.92116009
138ZFX_18555785_ChIP-Seq_MESCs_Mouse0.91970470
139HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.91578191
140TBX3_20139965_ChIP-Seq_ESCs_Mouse0.91497250
141TBX3_20139965_ChIP-Seq_MESCs_Mouse0.91220468
142SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.91099743
143ZFP281_27345836_Chip-Seq_ESCs_Mouse0.90715937
144KLF4_18555785_ChIP-Seq_MESCs_Mouse0.90137223
145CTNNB1_20460455_ChIP-Seq_HCT116_Human0.89183467
146* ATF3_27146783_Chip-Seq_COLON_Human0.89165515
147BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.87996313
148LXR_22158963_ChIP-Seq_LIVER_Mouse0.87465765

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen3.98164889
2MP0003941_abnormal_skin_development2.85085932
3MP0003303_peritoneal_inflammation2.68691876
4MP0003950_abnormal_plasma_membrane2.52540486
5MP0004510_myositis2.49497249
6MP0004272_abnormal_basement_membrane2.42170690
7MP0003566_abnormal_cell_adhesion2.33115471
8MP0001958_emphysema2.30455016
9MP0003705_abnormal_hypodermis_morpholog2.29175792
10MP0000920_abnormal_myelination2.14971774
11MP0005058_abnormal_lysosome_morphology2.14752629
12MP0005623_abnormal_meninges_morphology2.10337961
13MP0003091_abnormal_cell_migration2.05956259
14MP0003724_increased_susceptibility_to2.02053885
15MP0005275_abnormal_skin_tensile1.96249705
16MP0006082_CNS_inflammation1.89039953
17MP0003300_gastrointestinal_ulcer1.83930421
18MP0004084_abnormal_cardiac_muscle1.80181281
19MP0003690_abnormal_glial_cell1.75141873
20MP0001542_abnormal_bone_strength1.73194105
21MP0003448_altered_tumor_morphology1.70488395
22MP0004185_abnormal_adipocyte_glucose1.69481576
23MP0010030_abnormal_orbit_morphology1.69016744
24MP0001835_abnormal_antigen_presentation1.68104413
25MP0002060_abnormal_skin_morphology1.66360849
26MP0003436_decreased_susceptibility_to1.64405870
27MP0000343_altered_response_to1.63309280
28MP0009840_abnormal_foam_cell1.62909735
29MP0003828_pulmonary_edema1.62653448
30MP0001879_abnormal_lymphatic_vessel1.60653522
31MP0005387_immune_system_phenotype1.60246402
32MP0001790_abnormal_immune_system1.60246402
33MP0001533_abnormal_skeleton_physiology1.59266254
34MP0009785_altered_susceptibility_to1.59176414
35MP0000685_abnormal_immune_system1.58556080
36MP0003279_aneurysm1.53587617
37MP0000733_abnormal_muscle_development1.53478771
38MP0005000_abnormal_immune_tolerance1.50055893
39MP0002148_abnormal_hypersensitivity_rea1.49940971
40MP0010352_gastrointestinal_tract_polyps1.49341245
41MP0002419_abnormal_innate_immunity1.48742627
42MP0008775_abnormal_heart_ventricle1.48397242
43MP0005167_abnormal_blood-brain_barrier1.46691571
44MP0002138_abnormal_hepatobiliary_system1.43171004
45MP0000767_abnormal_smooth_muscle1.42861218
46MP0005508_abnormal_skeleton_morphology1.42382262
47MP0010368_abnormal_lymphatic_system1.37968146
48MP0002295_abnormal_pulmonary_circulatio1.37902071
49MP0009278_abnormal_bone_marrow1.37872270
50MP0000749_muscle_degeneration1.36809583
51MP0002933_joint_inflammation1.36121121
52MP0002896_abnormal_bone_mineralization1.33733897
53MP0000383_abnormal_hair_follicle1.33207370
54MP0005023_abnormal_wound_healing1.33066765
55MP0001849_ear_inflammation1.31798051
56MP0004947_skin_inflammation1.30715152
57MP0010678_abnormal_skin_adnexa1.30376479
58MP0003453_abnormal_keratinocyte_physiol1.29164375
59MP0004233_abnormal_muscle_weight1.29018068
60MP0001348_abnormal_lacrimal_gland1.28735057
61MP0000762_abnormal_tongue_morphology1.27828167
62MP0009053_abnormal_anal_canal1.27797104
63MP0005025_abnormal_response_to1.26377604
64MP0003385_abnormal_body_wall1.26259335
65MP0000604_amyloidosis1.26037997
66MP0001851_eye_inflammation1.24580509
67MP0000750_abnormal_muscle_regeneration1.23530254
68MP0001915_intracranial_hemorrhage1.22490427
69MP0002998_abnormal_bone_remodeling1.21623859
70MP0004858_abnormal_nervous_system1.19876343
71MP0009780_abnormal_chondrocyte_physiolo1.19716353
72MP0005164_abnormal_response_to1.18213750
73MP0000534_abnormal_ureter_morphology1.17133976
74MP0004036_abnormal_muscle_relaxation1.15311648
75MP0002108_abnormal_muscle_morphology1.15256734
76MP0004130_abnormal_muscle_cell1.14670088
77MP0002877_abnormal_melanocyte_morpholog1.14576420
78MP0009250_abnormal_appendicular_skeleto1.13123240
79MP0006054_spinal_hemorrhage1.13037533
80MP0010630_abnormal_cardiac_muscle1.12724520
81MP0002452_abnormal_antigen_presenting1.12583163
82MP0005595_abnormal_vascular_smooth1.12118048
83MP0005076_abnormal_cell_differentiation1.11908467
84MP0004087_abnormal_muscle_fiber1.11649708
85MP0006138_congestive_heart_failure1.09479800
86MP0002254_reproductive_system_inflammat1.07811985
87MP0005330_cardiomyopathy1.07630533
88MP0000428_abnormal_craniofacial_morphol1.07228905
89MP0000013_abnormal_adipose_tissue1.06142880
90MP0005503_abnormal_tendon_morphology1.05113954
91MP0005385_cardiovascular_system_phenoty1.04834128
92MP0001544_abnormal_cardiovascular_syste1.04834128
93MP0000759_abnormal_skeletal_muscle1.04791700
94MP0005666_abnormal_adipose_tissue1.00926682
95MP0003045_fibrosis0.99142900
96MP0005375_adipose_tissue_phenotype0.98970057
97MP0002723_abnormal_immune_serum0.98965619
98MP0001346_abnormal_lacrimal_gland0.98484956
99MP0002972_abnormal_cardiac_muscle0.98255101
100MP0005390_skeleton_phenotype0.95386181
101MP0005197_abnormal_uvea_morphology0.95376606
102MP0000537_abnormal_urethra_morphology0.95161797
103MP0003634_abnormal_glial_cell0.91924054
104MP0003942_abnormal_urinary_system0.91360206
105MP0005388_respiratory_system_phenotype0.91197641
106MP0002133_abnormal_respiratory_system0.91197641
107MP0003075_altered_response_to0.88754341
108MP0000432_abnormal_head_morphology0.88279735
109MP0002166_altered_tumor_susceptibility0.87799894
110* MP0001614_abnormal_blood_vessel0.87504243
111* MP0000249_abnormal_blood_vessel0.87485820
112MP0002128_abnormal_blood_circulation0.86470754
113MP0000003_abnormal_adipose_tissue0.85550608
114MP0001800_abnormal_humoral_immune0.85497362
115MP0005171_absent_coat_pigmentation0.85391388
116MP0002697_abnormal_eye_size0.85251028
117MP0000747_muscle_weakness0.84548002
118MP0001243_abnormal_dermal_layer0.84502800
119MP0002269_muscular_atrophy0.82514629
120MP0005257_abnormal_intraocular_pressure0.82229833
121MP0003115_abnormal_respiratory_system0.82190540
122MP0000751_myopathy0.81810140
123MP0008932_abnormal_embryonic_tissue0.81804801
124* MP0002925_abnormal_cardiovascular_devel0.81176265
125MP0009384_cardiac_valve_regurgitation0.80690696
126MP0005620_abnormal_muscle_contractility0.80228911
127MP0005621_abnormal_cell_physiology0.79631250
128MP0001819_abnormal_immune_cell0.79627909
129MP0000467_abnormal_esophagus_morphology0.79568922
130MP0002405_respiratory_system_inflammati0.78685441
131MP0000462_abnormal_digestive_system0.78486737
132MP0003191_abnormal_cellular_cholesterol0.78194751
133MP0002006_tumorigenesis0.78017788
134MP0005165_increased_susceptibility_to0.77471828
135MP0003221_abnormal_cardiomyocyte_apopto0.77430935
136MP0001299_abnormal_eye_distance/0.77035992
137MP0003755_abnormal_palate_morphology0.76781190
138MP0002420_abnormal_adaptive_immunity0.76572859
139MP0005409_darkened_coat_color0.76394286
140MP0003935_abnormal_craniofacial_develop0.75103497
141MP0003937_abnormal_limbs/digits/tail_de0.73542104
142MP0005193_abnormal_anterior_eye0.70165687
143MP0002084_abnormal_developmental_patter0.69321322
144MP0002085_abnormal_embryonic_tissue0.67430011
145MP0002086_abnormal_extraembryonic_tissu0.66802079
146MP0003984_embryonic_growth_retardation0.66436501
147MP0004215_abnormal_myocardial_fiber0.66362303
148MP0001730_embryonic_growth_arrest0.66052518
149MP0000579_abnormal_nail_morphology0.64898215
150MP0001672_abnormal_embryogenesis/_devel0.63732557
151MP0005380_embryogenesis_phenotype0.63732557
152MP0001175_abnormal_lung_morphology0.62865831

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)4.27456820
2Muscle fiber splitting (HP:0003555)3.84992302
3Osteolytic defects of the hand bones (HP:0009699)3.64779749
4Osteolytic defects of the phalanges of the hand (HP:0009771)3.64779749
5Bladder diverticulum (HP:0000015)3.38833679
6Hematochezia (HP:0002573)3.32001639
7Abnormality of macrophages (HP:0004311)3.18301400
8Follicular hyperkeratosis (HP:0007502)3.16914094
9Neurofibrillary tangles (HP:0002185)3.13744562
10Abnormality of dentin (HP:0010299)3.07293508
11Increased cerebral lipofuscin (HP:0011813)3.06285248
12Peritonitis (HP:0002586)3.02303676
13Hyporeflexia of lower limbs (HP:0002600)3.01760216
14Eczematoid dermatitis (HP:0000976)3.00796929
15Fragile skin (HP:0001030)3.00051532
16Ulnar bowing (HP:0003031)2.92429593
17Neonatal short-limb short stature (HP:0008921)2.83252652
18Cerebral aneurysm (HP:0004944)2.75816299
19Interstitial pulmonary disease (HP:0006530)2.75507416
20Genu recurvatum (HP:0002816)2.75064826
21Axonal loss (HP:0003447)2.72465588
22Blue sclerae (HP:0000592)2.64615258
23Recurrent abscess formation (HP:0002722)2.59955102
24Protrusio acetabuli (HP:0003179)2.59036802
25Broad metatarsal (HP:0001783)2.58801384
26Increased connective tissue (HP:0009025)2.57591412
27Mildly elevated creatine phosphokinase (HP:0008180)2.54715645
28Myocardial infarction (HP:0001658)2.54227153
29Overgrowth (HP:0001548)2.54017843
30Aortic dissection (HP:0002647)2.53980913
31Esophageal varix (HP:0002040)2.52898697
32Hypoplastic ischia (HP:0003175)2.51570484
33Shallow orbits (HP:0000586)2.50484371
34Pulmonary artery stenosis (HP:0004415)2.50195861
35Bowel diverticulosis (HP:0005222)2.49577457
36Scapular winging (HP:0003691)2.48853284
37Increased neuronal autofluorescent lipopigment (HP:0002074)2.47603759
38Thick nail (HP:0001805)2.46704963
39Spondylolisthesis (HP:0003302)2.46445188
40Cerebral inclusion bodies (HP:0100314)2.44469021
41Polycythemia (HP:0001901)2.41409074
42Cerebral hemorrhage (HP:0001342)2.38997024
43Mitral regurgitation (HP:0001653)2.38376363
44Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.36506883
45Ankle contracture (HP:0006466)2.34799852
46Hyperextensible skin (HP:0000974)2.33206419
47Loss of speech (HP:0002371)2.31621586
48Pterygium (HP:0001059)2.31485176
49Hypoplasia of the iris (HP:0007676)2.30938187
50Abnormality of skeletal muscle fiber size (HP:0012084)2.28861317
51Parakeratosis (HP:0001036)2.28773482
52Recurrent bacterial skin infections (HP:0005406)2.28556663
53Difficulty running (HP:0009046)2.26228476
54Tetraparesis (HP:0002273)2.24561175
55Chronic otitis media (HP:0000389)2.24453521
56Elbow flexion contracture (HP:0002987)2.24234988
57Vertebral compression fractures (HP:0002953)2.24041968
58Sensory axonal neuropathy (HP:0003390)2.22565772
59Joint laxity (HP:0001388)2.22395859
60Coronal craniosynostosis (HP:0004440)2.21509628
61Syringomyelia (HP:0003396)2.20994750
62Spinal cord lesions (HP:0100561)2.20994750
63Aortic regurgitation (HP:0001659)2.20208131
64Round ear (HP:0100830)2.19592903
65Wormian bones (HP:0002645)2.18433377
66Epiphyseal dysplasia (HP:0002656)2.18164201
67Abnormality of the ischium (HP:0003174)2.16906941
68Abnormal delivery (HP:0001787)2.16165199
69Spinal rigidity (HP:0003306)2.15424185
70Cervical subluxation (HP:0003308)2.15152094
71Slender build (HP:0001533)2.14863232
72Short nail (HP:0001799)2.13325068
73Biconcave vertebral bodies (HP:0004586)2.12462810
74Fused cervical vertebrae (HP:0002949)2.12032896
75Persistence of primary teeth (HP:0006335)2.11668336
76Abnormality of the acetabulum (HP:0003170)2.10973733
77Vacuolated lymphocytes (HP:0001922)2.10412295
78Aortic aneurysm (HP:0004942)2.09226698
79Abnormality of liposaccharide metabolism (HP:0010968)2.07812035
80Abnormality of glycosphingolipid metabolism (HP:0004343)2.07812035
81Abnormality of glycolipid metabolism (HP:0010969)2.07812035
82Spontaneous hematomas (HP:0007420)2.07010537
83Natal tooth (HP:0000695)2.03464482
84Generalized amyotrophy (HP:0003700)2.02806384
85Mitral stenosis (HP:0001718)2.02012834
86Breech presentation (HP:0001623)2.00727466
87Degeneration of the lateral corticospinal tracts (HP:0002314)2.00716064
88Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.00716064
89Stridor (HP:0010307)2.00409246
90Small epiphyses (HP:0010585)2.00145437
91Camptodactyly of toe (HP:0001836)1.99868825
92Wrist flexion contracture (HP:0001239)1.99030762
93Cupped ribs (HP:0000887)1.98775342
94Hepatosplenomegaly (HP:0001433)1.98362000
95Ectopia lentis (HP:0001083)1.98319457
96Metaphyseal cupping (HP:0003021)1.95426358
97Limb-girdle muscle weakness (HP:0003325)1.94413359
98Thin ribs (HP:0000883)1.94192926
99Wide anterior fontanel (HP:0000260)1.92603564
100Renal duplication (HP:0000075)1.91939755
101Onion bulb formation (HP:0003383)1.91777299
102Right ventricular cardiomyopathy (HP:0011663)1.90531652
103Distal upper limb amyotrophy (HP:0007149)1.90128612
104Upper limb amyotrophy (HP:0009129)1.90128612
105Aortic valve stenosis (HP:0001650)1.88771238
106Hyperacusis (HP:0010780)1.88060029
107Mitral valve prolapse (HP:0001634)1.85175845
108Porencephaly (HP:0002132)1.85061670
109Atrophic scars (HP:0001075)1.84176526
110Distal lower limb muscle weakness (HP:0009053)1.83635006
111Cellulitis (HP:0100658)1.83332727
112Flat acetabular roof (HP:0003180)1.82722373
113Orchitis (HP:0100796)1.82311420
114Disproportionate tall stature (HP:0001519)1.82230301
115Ventricular tachycardia (HP:0004756)1.82048425
116Emphysema (HP:0002097)1.81932184
117Arterial tortuosity (HP:0005116)1.81833031
118Aneurysm (HP:0002617)1.81492837
119Autoimmune thrombocytopenia (HP:0001973)1.81101139
120Premature skin wrinkling (HP:0100678)1.80933025
121Segmental peripheral demyelination/remyelination (HP:0003481)1.80480330
122Distal lower limb amyotrophy (HP:0008944)1.80478544
123Lower limb amyotrophy (HP:0007210)1.80210765
124Vascular tortuosity (HP:0004948)1.80090779
125Conjunctival telangiectasia (HP:0000524)1.79897038
126Recurrent gram-negative bacterial infections (HP:0005420)1.79361052
127Flat cornea (HP:0007720)1.78779342
128Abnormality of the vasculature of the conjunctiva (HP:0008054)1.78622603
129Knee flexion contracture (HP:0006380)1.78172483
130Elevated erythrocyte sedimentation rate (HP:0003565)1.78083061
131Increased variability in muscle fiber diameter (HP:0003557)1.77719914
132Bowing of the arm (HP:0006488)1.76807232
133Bowed forearm bones (HP:0003956)1.76807232
134Protruding ear (HP:0000411)1.76773141
135Exercise-induced muscle cramps (HP:0003710)1.76462301
136Abnormality of the calcaneus (HP:0008364)1.75424461
137Arnold-Chiari malformation (HP:0002308)1.74634131
138Abnormality of the nasal mucosa (HP:0000433)1.74539253
139Short hallux (HP:0010109)1.74127573
140Cardiovascular calcification (HP:0011915)1.73662094
141Difficulty climbing stairs (HP:0003551)1.73488402
142Soft skin (HP:0000977)1.73176124
143Dilatation of the ascending aorta (HP:0005111)1.73120059
144Absent frontal sinuses (HP:0002688)1.72890506
145Visceral angiomatosis (HP:0100761)1.72679640
146Vertebral arch anomaly (HP:0008438)1.72440655
147Abnormality of the umbilical cord (HP:0010881)1.72342091
148Abnormality of the peritoneum (HP:0002585)1.72248365
149Back pain (HP:0003418)1.71867929
150Abnormal vertebral ossification (HP:0100569)1.71670735
151Lipoatrophy (HP:0100578)1.70453266
152Calcaneovalgus deformity (HP:0001848)1.70310228
153Hemorrhage of the eye (HP:0011885)1.70013656
154Type 1 muscle fiber predominance (HP:0003803)1.69613254
155Delayed cranial suture closure (HP:0000270)1.68457942
156Deformed tarsal bones (HP:0008119)1.66519188
157Insomnia (HP:0100785)1.65329685
158Popliteal pterygium (HP:0009756)1.64199948
159Inguinal hernia (HP:0000023)1.64011173
160Pulmonic stenosis (HP:0001642)1.63663588
161Limited hip movement (HP:0008800)1.62245087
162Hammertoe (HP:0001765)1.61498328
163Deviation of the hallux (HP:0010051)1.61286409
164Flexion contracture of toe (HP:0005830)1.60827150
165Joint contractures involving the joints of the feet (HP:0100492)1.60827150
166Thin bony cortex (HP:0002753)1.60743444
167Hypoventilation (HP:0002791)1.60508909

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHB14.23543712
2MYLK3.53090660
3STK393.48395583
4LATS23.32996014
5TTN2.88074575
6PBK2.57937914
7MAP3K142.31918721
8NTRK12.27087693
9TBK12.23549816
10MET2.21167157
11TRIB32.16096917
12TIE12.09164473
13OXSR11.84888253
14TYK21.81684866
15BCR1.77040003
16EPHA31.63193373
17STK38L1.60423519
18WNK41.58868836
19BMX1.58755058
20EPHA21.57913791
21DMPK1.55915422
22DDR21.55606013
23KDR1.50604680
24ERN11.46156595
25JAK11.44157687
26STK101.43392817
27IKBKB1.43387572
28SCYL21.42344588
29ICK1.42264124
30JAK31.38419109
31FGFR41.36151907
32LRRK21.35966862
33PKN11.35754262
34BLK1.33905953
35TRPM71.32924155
36WNK11.32548526
37MAP3K131.31507545
38LIMK11.31426313
39FLT31.29873815
40FGR1.29710752
41CSK1.28072675
42PTK61.25658240
43TGFBR21.23668731
44IKBKE1.20437628
45MST41.19120046
46MUSK1.14826334
47TTK1.14748084
48STK31.09482542
49PDGFRA1.09274257
50PDGFRB1.05943544
51MAP3K31.01161762
52ROCK21.01045307
53KIT1.00644348
54RIPK11.00605197
55FGFR20.97619270
56CDK60.94737230
57PIK3CG0.94370721
58EEF2K0.94347996
59NEK10.93854921
60EPHB20.90724693
61PKN20.90631844
62PAK30.90345211
63STK380.89870645
64CHUK0.88077059
65NEK90.87905711
66MST1R0.87761354
67ARAF0.83803127
68LATS10.83433716
69LMTK20.83310990
70CDK120.82529278
71MAP3K100.82191426
72PRKD10.81011815
73IRAK40.80808124
74IRAK10.79856090
75SMG10.79685155
76ERBB40.78763112
77CAMK1D0.78098026
78CDC42BPA0.77932391
79PAK20.77243535
80ABL20.76794641
81GSK3A0.75031479
82TESK20.74734164
83STK40.74635260
84MAP3K60.74499541
85MOS0.71722788
86PAK40.70514439
87PTK20.69765676
88IRAK30.67203339
89EGFR0.66105466
90FGFR10.65289287
91BRSK20.65281759
92FGFR30.65207247
93JAK20.65186857
94DAPK30.65122512
95PIM20.64912316
96PTK2B0.64476243
97ABL10.63259003
98PLK20.62939575
99SIK10.62162056
100PDPK10.61428456
101TSSK60.60063468
102CSF1R0.59912525
103PLK30.59639271
104STK240.59571316
105RPS6KA40.59535986
106MAP3K80.59519092
107KSR20.58393585
108MARK30.58252136
109CDK180.57988732
110TGFBR10.57150903
111CDK150.56459261
112CSNK1A1L0.56008413
113KSR10.55801486
114RPS6KA20.55460952
115CDK140.55299364
116ILK0.55022667
117PAK60.54532820
118MAP4K10.54117881
119PAK10.53105259
120ERBB30.52804468
121MTOR0.51986506
122RPS6KA50.51803409
123BUB10.51797864
124CDK80.51719201
125PRKCQ0.51566446
126ROCK10.51205175
127FER0.50475240
128HCK0.50307364
129CAMK2D0.50006252
130PRPF4B0.49897496
131CDK11A0.48835136
132CAMK1G0.48693669
133INSR0.48601826
134PRKG20.47781524
135TESK10.46408839
136PRKD20.46145153
137EIF2AK30.45762779
138MAP2K20.45626287
139PIK3CA0.45427965
140CLK10.45315956
141TAOK20.44110846
142MELK0.43977450
143MAPKAPK20.43446573
144BRAF0.42924975
145NEK20.40249733
146EIF2AK10.38281673
147WEE10.37859447
148AKT30.37370535
149BRSK10.36939436
150CAMK2G0.36860872
151AURKB0.34248405

Predicted pathways (KEGG)

RankGene SetZ-score
1Malaria_Homo sapiens_hsa051442.76333112
2ECM-receptor interaction_Homo sapiens_hsa045122.22077481
3Leishmaniasis_Homo sapiens_hsa051402.20767160
4Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.05571263
5NF-kappa B signaling pathway_Homo sapiens_hsa040642.01486989
6Toll-like receptor signaling pathway_Homo sapiens_hsa046201.90757812
7Lysosome_Homo sapiens_hsa041421.81874523
8Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.77884567
9Osteoclast differentiation_Homo sapiens_hsa043801.76904481
10Focal adhesion_Homo sapiens_hsa045101.76183278
11Viral myocarditis_Homo sapiens_hsa054161.73779276
12Toxoplasmosis_Homo sapiens_hsa051451.73485443
13Pertussis_Homo sapiens_hsa051331.70164744
14Graft-versus-host disease_Homo sapiens_hsa053321.68967256
15Leukocyte transendothelial migration_Homo sapiens_hsa046701.68659838
16Allograft rejection_Homo sapiens_hsa053301.67079657
17Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.65803729
18TNF signaling pathway_Homo sapiens_hsa046681.65568770
19Shigellosis_Homo sapiens_hsa051311.60702880
20NOD-like receptor signaling pathway_Homo sapiens_hsa046211.57526110
21Salmonella infection_Homo sapiens_hsa051321.53895325
22Amoebiasis_Homo sapiens_hsa051461.53717310
23Rheumatoid arthritis_Homo sapiens_hsa053231.52228573
24Renal cell carcinoma_Homo sapiens_hsa052111.51993651
25Central carbon metabolism in cancer_Homo sapiens_hsa052301.51827594
26Proteoglycans in cancer_Homo sapiens_hsa052051.51513774
27Small cell lung cancer_Homo sapiens_hsa052221.49611349
28Steroid biosynthesis_Homo sapiens_hsa001001.48386004
29Legionellosis_Homo sapiens_hsa051341.47471621
30Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.46138972
31Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.44247182
32Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.42866292
33AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.42488508
34Staphylococcus aureus infection_Homo sapiens_hsa051501.40530565
35Measles_Homo sapiens_hsa051621.36440655
36Dilated cardiomyopathy_Homo sapiens_hsa054141.36330938
37Tuberculosis_Homo sapiens_hsa051521.35877009
38Phagosome_Homo sapiens_hsa041451.35459248
39Melanoma_Homo sapiens_hsa052181.32897644
40Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.31483184
41Apoptosis_Homo sapiens_hsa042101.31298732
42Thyroid cancer_Homo sapiens_hsa052161.26243274
43Regulation of actin cytoskeleton_Homo sapiens_hsa048101.25042213
44B cell receptor signaling pathway_Homo sapiens_hsa046621.22068439
45Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.19854263
46Adipocytokine signaling pathway_Homo sapiens_hsa049201.17560932
47Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.17083403
48Autoimmune thyroid disease_Homo sapiens_hsa053201.16775692
49RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.14305668
50Hepatitis C_Homo sapiens_hsa051601.11010225
51Gap junction_Homo sapiens_hsa045401.10350686
52Influenza A_Homo sapiens_hsa051641.10088618
53Chemokine signaling pathway_Homo sapiens_hsa040621.09445451
54Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.08761190
55MicroRNAs in cancer_Homo sapiens_hsa052061.06875757
56Adherens junction_Homo sapiens_hsa045201.06687645
57Chronic myeloid leukemia_Homo sapiens_hsa052201.05595462
58Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.05460886
59Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.05342496
60p53 signaling pathway_Homo sapiens_hsa041151.04889082
61Dorso-ventral axis formation_Homo sapiens_hsa043201.03971882
62Endocytosis_Homo sapiens_hsa041441.03878543
63Tight junction_Homo sapiens_hsa045301.02695050
64Basal cell carcinoma_Homo sapiens_hsa052171.00349035
65Glioma_Homo sapiens_hsa052141.00210546
66Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.99130589
67Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.98909150
68Endometrial cancer_Homo sapiens_hsa052130.98213272
69Cell cycle_Homo sapiens_hsa041100.95675003
70Jak-STAT signaling pathway_Homo sapiens_hsa046300.95248782
71Fatty acid elongation_Homo sapiens_hsa000620.94030911
72Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.92203253
73Pancreatic cancer_Homo sapiens_hsa052120.91924032
74Antigen processing and presentation_Homo sapiens_hsa046120.91666198
75Thyroid hormone signaling pathway_Homo sapiens_hsa049190.91604288
76Hedgehog signaling pathway_Homo sapiens_hsa043400.89537699
77Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.89069217
78Asthma_Homo sapiens_hsa053100.87920996
79Biosynthesis of amino acids_Homo sapiens_hsa012300.85536852
80PI3K-Akt signaling pathway_Homo sapiens_hsa041510.84786406
81Sphingolipid metabolism_Homo sapiens_hsa006000.84709923
82Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.83836731
83Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.83480023
84Melanogenesis_Homo sapiens_hsa049160.83092836
85Colorectal cancer_Homo sapiens_hsa052100.82371664
86Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.81621321
87Hepatitis B_Homo sapiens_hsa051610.79912287
88Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.79730623
89Sphingolipid signaling pathway_Homo sapiens_hsa040710.79673143
90Platelet activation_Homo sapiens_hsa046110.78990839
91Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.78477649
92African trypanosomiasis_Homo sapiens_hsa051430.78473176
932-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.76953589
94Wnt signaling pathway_Homo sapiens_hsa043100.76648794
95Ether lipid metabolism_Homo sapiens_hsa005650.76336124
96Intestinal immune network for IgA production_Homo sapiens_hsa046720.76010800
97Viral carcinogenesis_Homo sapiens_hsa052030.75312148
98Herpes simplex infection_Homo sapiens_hsa051680.74765614
99Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.73817237
100Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.73251141
101Vibrio cholerae infection_Homo sapiens_hsa051100.73055621
102Hematopoietic cell lineage_Homo sapiens_hsa046400.72946108
103Notch signaling pathway_Homo sapiens_hsa043300.71863405
104TGF-beta signaling pathway_Homo sapiens_hsa043500.70398488
105Prostate cancer_Homo sapiens_hsa052150.70274381
106HIF-1 signaling pathway_Homo sapiens_hsa040660.69669322
107Acute myeloid leukemia_Homo sapiens_hsa052210.68301383
108Pentose phosphate pathway_Homo sapiens_hsa000300.66776533
109Insulin resistance_Homo sapiens_hsa049310.66412130
110Axon guidance_Homo sapiens_hsa043600.65388501
111Neurotrophin signaling pathway_Homo sapiens_hsa047220.64619764
112N-Glycan biosynthesis_Homo sapiens_hsa005100.64284968
113Protein digestion and absorption_Homo sapiens_hsa049740.62512708
114VEGF signaling pathway_Homo sapiens_hsa043700.62244172
115cGMP-PKG signaling pathway_Homo sapiens_hsa040220.61330254
116Vitamin B6 metabolism_Homo sapiens_hsa007500.60770320
117Glycosaminoglycan degradation_Homo sapiens_hsa005310.59276608
118Galactose metabolism_Homo sapiens_hsa000520.58963539
119ErbB signaling pathway_Homo sapiens_hsa040120.58787153
120Phospholipase D signaling pathway_Homo sapiens_hsa040720.56897788
121Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.56387129
122Pathways in cancer_Homo sapiens_hsa052000.56312173
123Insulin signaling pathway_Homo sapiens_hsa049100.54945293
124AMPK signaling pathway_Homo sapiens_hsa041520.54342928
125Hippo signaling pathway_Homo sapiens_hsa043900.53988549
126Estrogen signaling pathway_Homo sapiens_hsa049150.52483224
127Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.52158429
128T cell receptor signaling pathway_Homo sapiens_hsa046600.50959690
129Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.50841672
130Longevity regulating pathway - mammal_Homo sapiens_hsa042110.50362416
131Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.49955859
132Type I diabetes mellitus_Homo sapiens_hsa049400.49407665
133Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49292208
134Prion diseases_Homo sapiens_hsa050200.48787458
135HTLV-I infection_Homo sapiens_hsa051660.47906226
136Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.47386723
137Carbon metabolism_Homo sapiens_hsa012000.46939016
138Lysine degradation_Homo sapiens_hsa003100.46897941
139Ras signaling pathway_Homo sapiens_hsa040140.46686575
140Prolactin signaling pathway_Homo sapiens_hsa049170.45848226
141Other glycan degradation_Homo sapiens_hsa005110.45762934
142Non-small cell lung cancer_Homo sapiens_hsa052230.44862376
143Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.44764588
144PPAR signaling pathway_Homo sapiens_hsa033200.44432803
145Rap1 signaling pathway_Homo sapiens_hsa040150.44235383
146Vascular smooth muscle contraction_Homo sapiens_hsa042700.43949349
147Bladder cancer_Homo sapiens_hsa052190.42592741
148FoxO signaling pathway_Homo sapiens_hsa040680.38664353
149Thyroid hormone synthesis_Homo sapiens_hsa049180.35572156

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »