CLIC4P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)8.03649272
2ATP synthesis coupled proton transport (GO:0015986)7.12979246
3energy coupled proton transport, down electrochemical gradient (GO:0015985)7.12979246
4establishment of protein localization to mitochondrial membrane (GO:0090151)6.52408081
5ribosomal small subunit biogenesis (GO:0042274)6.02280966
6chaperone-mediated protein transport (GO:0072321)5.58518695
7viral transcription (GO:0019083)5.29324448
8mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.11822346
9translational termination (GO:0006415)5.10117391
10SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.04698493
11DNA deamination (GO:0045006)5.03329507
12cotranslational protein targeting to membrane (GO:0006613)5.01121319
13protein targeting to ER (GO:0045047)4.99322665
14respiratory electron transport chain (GO:0022904)4.94446514
15transcription from mitochondrial promoter (GO:0006390)4.90639400
16rRNA modification (GO:0000154)4.84328851
17mitochondrial respiratory chain complex assembly (GO:0033108)4.80782216
18rRNA methylation (GO:0031167)4.80760384
19establishment of protein localization to endoplasmic reticulum (GO:0072599)4.80308938
20electron transport chain (GO:0022900)4.80109483
21protein complex biogenesis (GO:0070271)4.76964837
22protein localization to endoplasmic reticulum (GO:0070972)4.69234185
23proteasome assembly (GO:0043248)4.68492459
24mitochondrial respiratory chain complex I assembly (GO:0032981)4.61618319
25NADH dehydrogenase complex assembly (GO:0010257)4.61618319
26mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.61618319
27transcription elongation from RNA polymerase I promoter (GO:0006362)4.56646185
28water-soluble vitamin biosynthetic process (GO:0042364)4.52886262
29translational elongation (GO:0006414)4.47688124
30ribosomal large subunit biogenesis (GO:0042273)4.43664213
31translation (GO:0006412)4.20783290
32formation of translation preinitiation complex (GO:0001731)4.00921491
33viral life cycle (GO:0019058)4.00756440
34translational initiation (GO:0006413)4.00501463
35ATP biosynthetic process (GO:0006754)3.99909643
36ribosomal small subunit assembly (GO:0000028)3.98347664
37termination of RNA polymerase I transcription (GO:0006363)3.94508233
38cytidine deamination (GO:0009972)3.83055351
39cytidine metabolic process (GO:0046087)3.83055351
40cytidine catabolic process (GO:0006216)3.83055351
41protein neddylation (GO:0045116)3.82979989
42maturation of 5.8S rRNA (GO:0000460)3.80464494
43cellular protein complex disassembly (GO:0043624)3.79132868
44purine nucleoside triphosphate biosynthetic process (GO:0009145)3.76741429
45regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.71993085
46purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.70721806
47nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.70605185
48cellular component biogenesis (GO:0044085)3.69972986
49exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.68060712
50ribonucleoprotein complex biogenesis (GO:0022613)3.62715968
51mitochondrial RNA metabolic process (GO:0000959)3.56447494
52hydrogen ion transmembrane transport (GO:1902600)3.56191920
53nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.54094678
54establishment of integrated proviral latency (GO:0075713)3.53975804
55rRNA processing (GO:0006364)3.52300138
56ER overload response (GO:0006983)3.51682222
57ribonucleoside triphosphate biosynthetic process (GO:0009201)3.45532809
58innate immune response in mucosa (GO:0002227)3.41595275
59respiratory chain complex IV assembly (GO:0008535)3.37208315
60rRNA metabolic process (GO:0016072)3.37038203
61protein targeting to membrane (GO:0006612)3.36277628
62transcription from RNA polymerase I promoter (GO:0006360)3.33758616
63maturation of SSU-rRNA (GO:0030490)3.33648935
64transcription initiation from RNA polymerase I promoter (GO:0006361)3.28198584
65protein targeting to mitochondrion (GO:0006626)3.26964553
66cytochrome complex assembly (GO:0017004)3.24987768
67cullin deneddylation (GO:0010388)3.24283103
68energy homeostasis (GO:0097009)3.23588305
69ribosome assembly (GO:0042255)3.22334945
70establishment of viral latency (GO:0019043)3.21682194
71pyrimidine ribonucleoside catabolic process (GO:0046133)3.20076806
72negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.18668227
73establishment of protein localization to mitochondrion (GO:0072655)3.10590248
74DNA catabolic process, exonucleolytic (GO:0000738)3.08442403
75morphogenesis of an endothelium (GO:0003159)3.07622316
76endothelial tube morphogenesis (GO:0061154)3.07622316
77protein complex disassembly (GO:0043241)3.05126263
78UTP biosynthetic process (GO:0006228)3.03135962
79positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.01917726
807-methylguanosine mRNA capping (GO:0006370)3.00402685
81proton transport (GO:0015992)2.99321038
82nucleoside triphosphate biosynthetic process (GO:0009142)2.99050369
83spliceosomal snRNP assembly (GO:0000387)2.98202108
84macromolecular complex disassembly (GO:0032984)2.97213841
85pseudouridine synthesis (GO:0001522)2.96791483
86negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 2.96451362
87nuclear-transcribed mRNA catabolic process (GO:0000956)2.96321743
88intracellular protein transmembrane import (GO:0044743)2.95853478
89RNA capping (GO:0036260)2.94264095
907-methylguanosine RNA capping (GO:0009452)2.94264095
91protein localization to mitochondrion (GO:0070585)2.91844865
92hydrogen transport (GO:0006818)2.91187406
93negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.89936922
94negative regulation of ligase activity (GO:0051352)2.89936922
95cellular response to zinc ion (GO:0071294)2.88208540
96nucleotide-excision repair, DNA damage removal (GO:0000718)2.87715049
97DNA excision (GO:0044349)2.87715049
98regulation of oxidative phosphorylation (GO:0002082)2.85785379
99regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.83411220
100protein-cofactor linkage (GO:0018065)2.82288942

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse8.59358015
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.88333312
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.62827776
4EST1_17652178_ChIP-ChIP_JURKAT_Human4.28186702
5ELF1_17652178_ChIP-ChIP_JURKAT_Human3.44686673
6ELK1_19687146_ChIP-ChIP_HELA_Human3.31465574
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.28002345
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.17845755
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.15680944
10MYC_18555785_ChIP-Seq_MESCs_Mouse3.08374306
11E2F4_17652178_ChIP-ChIP_JURKAT_Human3.01810869
12CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.98272839
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.97370068
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.87520464
15VDR_23849224_ChIP-Seq_CD4+_Human2.80680020
16CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.49804589
17BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.38420581
18PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.32403845
19HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.26716450
20FOXP3_21729870_ChIP-Seq_TREG_Human2.22097259
21EGR1_23403033_ChIP-Seq_LIVER_Mouse2.18440347
22DCP1A_22483619_ChIP-Seq_HELA_Human2.18407152
23MYC_19030024_ChIP-ChIP_MESCs_Mouse2.17570702
24EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.12312710
25HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.10640960
26SRF_21415370_ChIP-Seq_HL-1_Mouse2.10356070
27POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.05850415
28PADI4_21655091_ChIP-ChIP_MCF-7_Human2.03838885
29HOXB4_20404135_ChIP-ChIP_EML_Mouse1.95015465
30E2F1_18555785_ChIP-Seq_MESCs_Mouse1.89948163
31MYC_18358816_ChIP-ChIP_MESCs_Mouse1.88224996
32NELFA_20434984_ChIP-Seq_ESCs_Mouse1.87408628
33MYC_19079543_ChIP-ChIP_MESCs_Mouse1.83422967
34FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.80629903
35ELK1_22589737_ChIP-Seq_MCF10A_Human1.74589321
36ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.74283922
37TTF2_22483619_ChIP-Seq_HELA_Human1.73170736
38THAP11_20581084_ChIP-Seq_MESCs_Mouse1.72755574
39MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.71542781
40SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.71215721
41YY1_21170310_ChIP-Seq_MESCs_Mouse1.69844590
42E2F7_22180533_ChIP-Seq_HELA_Human1.65884299
43SOX2_16153702_ChIP-ChIP_HESCs_Human1.64947509
44XRN2_22483619_ChIP-Seq_HELA_Human1.64745068
45IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.63952135
46SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.52538289
47MYC_18940864_ChIP-ChIP_HL60_Human1.51375371
48PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.49906432
49NANOG_16153702_ChIP-ChIP_HESCs_Human1.49665189
50HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.48116577
51FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.47039395
52POU5F1_16153702_ChIP-ChIP_HESCs_Human1.41855736
53PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.40759986
54CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.40672786
55NANOG_18555785_ChIP-Seq_MESCs_Mouse1.39934749
56GABP_19822575_ChIP-Seq_HepG2_Human1.37604409
57IRF1_19129219_ChIP-ChIP_H3396_Human1.35921337
58MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.35790198
59EWS_26573619_Chip-Seq_HEK293_Human1.34652127
60POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.29460309
61ESR1_15608294_ChIP-ChIP_MCF-7_Human1.29035238
62ERG_20887958_ChIP-Seq_HPC-7_Mouse1.24779019
63NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.20645556
64HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.20409352
65SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.19565085
66ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.18836007
67ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.18012360
68VDR_22108803_ChIP-Seq_LS180_Human1.17129449
69SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.16588456
70TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.15341800
71GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14420273
72FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.11264153
73YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.09784012
74CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.09034724
75E2F1_21310950_ChIP-Seq_MCF-7_Human1.06993463
76SALL4_22934838_ChIP-ChIP_CD34+_Human1.02706895
77CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.98206725
78TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.90716806
79NOTCH1_21737748_ChIP-Seq_TLL_Human0.86274198
80MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.82823538
81SOX2_18555785_ChIP-Seq_MESCs_Mouse0.80435137
82IRF8_21731497_ChIP-ChIP_J774_Mouse0.80366212
83BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.80235286
84TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.79996742
85NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.79918959
86MYCN_18555785_ChIP-Seq_MESCs_Mouse0.79496311
87NANOG_19829295_ChIP-Seq_ESCs_Human0.79288588
88SOX2_19829295_ChIP-Seq_ESCs_Human0.79288588
89SOX17_20123909_ChIP-Seq_XEN_Mouse0.78770297
90RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.78245748
91EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.78061512
92POU3F2_20337985_ChIP-ChIP_501MEL_Human0.77407543
93RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.77263009
94FUS_26573619_Chip-Seq_HEK293_Human0.76964395
95GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.75636456
96KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.75611389
97POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.75450799
98AR_21909140_ChIP-Seq_LNCAP_Human0.74532889
99ELF5_23300383_ChIP-Seq_T47D_Human0.73400575
100SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.71005211

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis5.30803914
2MP0003011_delayed_dark_adaptation3.56588327
3MP0003186_abnormal_redox_activity3.10485438
4MP0006072_abnormal_retinal_apoptosis2.94451179
5MP0003950_abnormal_plasma_membrane2.85568525
6MP0000685_abnormal_immune_system2.63730170
7MP0004957_abnormal_blastocyst_morpholog2.55196745
8MP0002638_abnormal_pupillary_reflex2.54664175
9MP0005623_abnormal_meninges_morphology2.49650691
10MP0002102_abnormal_ear_morphology2.49128941
11MP0002938_white_spotting2.42646482
12MP0008058_abnormal_DNA_repair2.40501683
13MP0010386_abnormal_urinary_bladder2.28300306
14MP0003718_maternal_effect2.27791710
15MP0008057_abnormal_DNA_replication2.21243593
16MP0002295_abnormal_pulmonary_circulatio2.18404490
17MP0002148_abnormal_hypersensitivity_rea2.13965141
18MP0005084_abnormal_gallbladder_morpholo2.07184658
19MP0003941_abnormal_skin_development1.91990361
20MP0003693_abnormal_embryo_hatching1.91560825
21MP0002138_abnormal_hepatobiliary_system1.77534166
22MP0006292_abnormal_olfactory_placode1.74937361
23MP0005671_abnormal_response_to1.74351919
24MP0008875_abnormal_xenobiotic_pharmacok1.74191766
25MP0009697_abnormal_copulation1.71521429
26MP0003077_abnormal_cell_cycle1.63044287
27MP0009046_muscle_twitch1.62369655
28MP0009379_abnormal_foot_pigmentation1.59739543
29MP0003878_abnormal_ear_physiology1.49438413
30MP0005377_hearing/vestibular/ear_phenot1.49438413
31MP0002132_abnormal_respiratory_system1.46059211
32MP0005408_hypopigmentation1.44971347
33MP0005253_abnormal_eye_physiology1.41517706
34MP0006036_abnormal_mitochondrial_physio1.39369259
35MP0005387_immune_system_phenotype1.37630907
36MP0001790_abnormal_immune_system1.37630907
37MP0009785_altered_susceptibility_to1.36296031
38MP0001800_abnormal_humoral_immune1.35437849
39MP0003111_abnormal_nucleus_morphology1.32298141
40MP0003329_amyloid_beta_deposits1.32184317
41MP0001835_abnormal_antigen_presentation1.31123479
42MP0004272_abnormal_basement_membrane1.27436218
43MP0008932_abnormal_embryonic_tissue1.26135738
44MP0001905_abnormal_dopamine_level1.25880954
45MP0000358_abnormal_cell_content/1.25837242
46MP0004145_abnormal_muscle_electrophysio1.25339223
47MP0001853_heart_inflammation1.23620588
48MP0003195_calcinosis1.21972144
49MP0001764_abnormal_homeostasis1.19851048
50MP0005332_abnormal_amino_acid1.19077230
51MP0001879_abnormal_lymphatic_vessel1.18414482
52MP0003567_abnormal_fetal_cardiomyocyte1.18034147
53MP0002277_abnormal_respiratory_mucosa1.17847097
54MP0010094_abnormal_chromosome_stability1.17543412
55MP0000343_altered_response_to1.16160852
56MP0002876_abnormal_thyroid_physiology1.15781988
57MP0004142_abnormal_muscle_tone1.09391161
58MP0000604_amyloidosis1.08346462
59MP0004742_abnormal_vestibular_system1.07512918
60MP0005645_abnormal_hypothalamus_physiol1.06391872
61MP0006054_spinal_hemorrhage1.04505380
62MP0001440_abnormal_grooming_behavior1.01475785
63MP0003638_abnormal_response/metabolism_1.00666027
64MP0002282_abnormal_trachea_morphology0.99745273
65MP0000569_abnormal_digit_pigmentation0.99534149
66MP0005395_other_phenotype0.99289985
67MP0003252_abnormal_bile_duct0.97388390
68MP0005551_abnormal_eye_electrophysiolog0.92842309
69MP0001542_abnormal_bone_strength0.91764015
70MP0005266_abnormal_metabolism0.90958762
71MP0010368_abnormal_lymphatic_system0.89756878
72MP0001485_abnormal_pinna_reflex0.89414220
73MP0008872_abnormal_physiological_respon0.89078583
74MP0000371_diluted_coat_color0.87395895
75MP0001293_anophthalmia0.85958062
76MP0002160_abnormal_reproductive_system0.85229442
77MP0005330_cardiomyopathy0.84487806
78MP0005166_decreased_susceptibility_to0.81685823
79MP0003122_maternal_imprinting0.80866697
80MP0005410_abnormal_fertilization0.79891481
81MP0010030_abnormal_orbit_morphology0.78951578
82MP0001881_abnormal_mammary_gland0.78547580
83MP0002452_abnormal_antigen_presenting0.75651589
84MP0002736_abnormal_nociception_after0.74198383
85MP0005000_abnormal_immune_tolerance0.72008309
86MP0008007_abnormal_cellular_replicative0.68556738
87MP0005636_abnormal_mineral_homeostasis0.68335061
88MP0009780_abnormal_chondrocyte_physiolo0.68116388
89MP0002723_abnormal_immune_serum0.68109090
90MP0002928_abnormal_bile_duct0.68003724
91MP0001845_abnormal_inflammatory_respons0.67757063
92MP0002163_abnormal_gland_morphology0.64932741
93MP0001502_abnormal_circadian_rhythm0.64822837
94MP0000631_abnormal_neuroendocrine_gland0.64067883
95MP0002272_abnormal_nervous_system0.62899239
96MP0000647_abnormal_sebaceous_gland0.62078642
97MP0003448_altered_tumor_morphology0.60247290
98MP0001191_abnormal_skin_condition0.58423287
99MP0003300_gastrointestinal_ulcer0.58125319
100MP0001348_abnormal_lacrimal_gland0.58079724

Predicted human phenotypes

RankGene SetZ-score
1Increased hepatocellular lipid droplets (HP:0006565)6.09065314
2Lipid accumulation in hepatocytes (HP:0006561)5.55194218
3Acute necrotizing encephalopathy (HP:0006965)5.24212456
4Mitochondrial inheritance (HP:0001427)5.01506501
5Renal Fanconi syndrome (HP:0001994)4.89856705
6Abnormal mitochondria in muscle tissue (HP:0008316)4.81581859
7Increased CSF lactate (HP:0002490)4.67242589
8Macrocytic anemia (HP:0001972)4.58790532
9Acute encephalopathy (HP:0006846)4.51703954
10Progressive macrocephaly (HP:0004481)4.21552533
11Methylmalonic acidemia (HP:0002912)4.03628372
12Oral leukoplakia (HP:0002745)3.95483280
13Methylmalonic aciduria (HP:0012120)3.86556378
14Exertional dyspnea (HP:0002875)3.71983149
153-Methylglutaconic aciduria (HP:0003535)3.67925997
16Abnormality of cells of the erythroid lineage (HP:0012130)3.67080393
17Hepatocellular necrosis (HP:0001404)3.65903095
18Decreased activity of mitochondrial respiratory chain (HP:0008972)3.57583766
19Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.57583766
20Abnormal number of erythroid precursors (HP:0012131)3.56660777
21Increased intramyocellular lipid droplets (HP:0012240)3.56464920
22Confusion (HP:0001289)3.54998663
23Hepatic necrosis (HP:0002605)3.53827220
24Congenital, generalized hypertrichosis (HP:0004540)3.53584252
25Hyperphosphaturia (HP:0003109)3.42829828
26Respiratory difficulties (HP:0002880)3.38060421
27Cerebral edema (HP:0002181)3.37410391
28Reticulocytopenia (HP:0001896)3.28716159
29Abnormality of methionine metabolism (HP:0010901)3.23800072
30Leukodystrophy (HP:0002415)3.19609215
31Abnormality of renal resorption (HP:0011038)3.19585169
32Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.18027694
33Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.16400038
34Abnormality of glycolysis (HP:0004366)3.08373666
35Aplastic anemia (HP:0001915)3.03270613
36Amniotic constriction ring (HP:0009775)2.94913587
37Abnormality of placental membranes (HP:0011409)2.94913587
38Increased muscle lipid content (HP:0009058)2.92333041
39Respiratory failure (HP:0002878)2.91617897
40Increased serum lactate (HP:0002151)2.89009743
41Exercise intolerance (HP:0003546)2.84348709
42Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.78578613
43IgM deficiency (HP:0002850)2.78564441
44Lactic acidosis (HP:0003128)2.76055546
45Abnormal urine phosphate concentration (HP:0012599)2.68656144
46Glycosuria (HP:0003076)2.67260715
47Abnormality of urine glucose concentration (HP:0011016)2.67260715
48Megaloblastic anemia (HP:0001889)2.64479902
49IgG deficiency (HP:0004315)2.59784733
50Abnormality of aspartate family amino acid metabolism (HP:0010899)2.59491060
51Abnormality of the vitamin B12 metabolism (HP:0004341)2.52792757
52Pallor (HP:0000980)2.51272442
53Abnormality of vitamin B metabolism (HP:0004340)2.37348808
54Cerebral hypomyelination (HP:0006808)2.30378552
55Delayed CNS myelination (HP:0002188)2.28176855
56Abnormality of serum amino acid levels (HP:0003112)2.26225906
57IgA deficiency (HP:0002720)2.25774269
58Congenital ichthyosiform erythroderma (HP:0007431)2.22657027
59Parakeratosis (HP:0001036)2.22369178
60Increased serum pyruvate (HP:0003542)2.19722597
61Type I transferrin isoform profile (HP:0003642)2.19188201
62Lethargy (HP:0001254)2.18430936
63Porencephaly (HP:0002132)2.10670174
64Abnormality of aromatic amino acid family metabolism (HP:0004338)2.10476697
65Gastrointestinal stroma tumor (HP:0100723)2.06419499
66Molar tooth sign on MRI (HP:0002419)2.02963565
67Abnormality of midbrain morphology (HP:0002418)2.02963565
68Abnormality of homocysteine metabolism (HP:0010919)2.02819871
69Homocystinuria (HP:0002156)2.02819871
70Pancytopenia (HP:0001876)2.00148815
71Sparse eyelashes (HP:0000653)1.98894971
72Optic disc pallor (HP:0000543)1.98325023
73Abnormality of dicarboxylic acid metabolism (HP:0010995)1.97542587
74Dicarboxylic aciduria (HP:0003215)1.97542587
75Metabolic acidosis (HP:0001942)1.91402316
76Abnormality of the pons (HP:0007361)1.91195136
77Neuroendocrine neoplasm (HP:0100634)1.85239839
78Abnormality of alanine metabolism (HP:0010916)1.81619568
79Hyperalaninemia (HP:0003348)1.81619568
80Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.81619568
81Neoplasm of the peripheral nervous system (HP:0100007)1.81314674
82Hyperglycinemia (HP:0002154)1.80552291
83X-linked dominant inheritance (HP:0001423)1.79131164
84CNS demyelination (HP:0007305)1.76607041
85Rough bone trabeculation (HP:0100670)1.75971320
86Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.74961448
87Abnormal protein N-linked glycosylation (HP:0012347)1.74961448
88Abnormal protein glycosylation (HP:0012346)1.74961448
89Abnormal glycosylation (HP:0012345)1.74961448
90Degeneration of anterior horn cells (HP:0002398)1.71954245
91Abnormality of the anterior horn cell (HP:0006802)1.71954245
92Renal tubular dysfunction (HP:0000124)1.70815128
93Hypoalbuminemia (HP:0003073)1.70332697
94Abnormal albumin level (HP:0012116)1.70332697
95Generalized aminoaciduria (HP:0002909)1.68240660
96Horseshoe kidney (HP:0000085)1.67492145
97Hypoplasia of the pons (HP:0012110)1.67254834
98Woolly hair (HP:0002224)1.66275685
99Pancreatic cysts (HP:0001737)1.65679346
100Concave nail (HP:0001598)1.63356005

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK4.93317795
2VRK14.74895435
3MST44.39502762
4VRK24.23350361
5TLK13.83277931
6SIK33.66525033
7STK163.08915077
8MAP3K122.88575155
9EIF2AK32.33002562
10TRIM282.28234413
11DAPK32.19773334
12TAF12.13323552
13NME11.96056550
14PDK21.81904073
15BCR1.73909329
16BUB11.68049965
17TSSK61.67339727
18DYRK21.60955519
19PBK1.48116249
20CDC71.47623703
21CDK81.34640284
22SRPK11.33541053
23RPS6KA51.31433497
24OXSR11.27593413
25NUAK11.14583872
26CDK191.10853002
27TIE11.09751612
28RPS6KB21.09193425
29AURKA1.09192254
30EIF2AK11.09075144
31MKNK21.03032611
32BMPR1B1.02895853
33PIK3CG1.01273393
34PLK30.97113968
35TNIK0.96056327
36AURKB0.91174449
37PHKG20.90890668
38PHKG10.90890668
39ADRBK20.85841269
40EIF2AK20.85724417
41MYLK0.84763418
42PLK40.82948243
43WNK30.78814544
44BCKDK0.78701233
45GRK10.78571238
46CHEK20.78160608
47TAOK30.77551221
48MKNK10.75203519
49SIK10.74518905
50BLK0.70332448
51PLK20.69759469
52STK390.68395267
53IKBKB0.67705353
54PINK10.64957701
55WNK40.64597364
56AKT20.63660006
57STK40.63267056
58LMTK20.62718220
59ARAF0.62666541
60BRSK20.62233170
61NEK10.59564100
62CASK0.57832125
63DAPK20.54942523
64TXK0.50029232
65EPHB20.49977811
66CSNK2A20.49805405
67MAP4K20.49504356
68PRKCQ0.49063379
69MOS0.49050074
70NLK0.46029808
71STK240.44056628
72PRKCD0.37347468
73CHUK0.37224447
74PASK0.37171082
75CSNK1A1L0.35220706
76IRAK40.33030027
77CSNK2A10.32385690
78CSNK1A10.31958797
79ATR0.31767418
80MUSK0.30162117
81PAK20.29261822
82STK30.28983603
83FGFR10.28670019
84STK38L0.28665838
85CSNK1G10.28236289
86PLK10.27940181
87PIM10.27048576
88CHEK10.26601164
89CDK90.26227055
90PRKCG0.25901651
91PRKG20.25896849
92PRKCE0.25680680
93ACVR1B0.23486650
94TGFBR10.22952786
95LYN0.22694745
96ALK0.21845094
97CCNB10.21333883
98ABL20.20900913
99MINK10.19625748
100DAPK10.19278270

Predicted pathways (KEGG)

RankGene SetZ-score
1Systemic lupus erythematosus_Homo sapiens_hsa053224.70138968
2Ribosome_Homo sapiens_hsa030104.64993993
3Oxidative phosphorylation_Homo sapiens_hsa001904.53791289
4Proteasome_Homo sapiens_hsa030503.66837472
5Parkinsons disease_Homo sapiens_hsa050123.47985669
6Protein export_Homo sapiens_hsa030603.22434851
7Alcoholism_Homo sapiens_hsa050342.84887663
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.63316309
9Alzheimers disease_Homo sapiens_hsa050102.57955690
10Huntingtons disease_Homo sapiens_hsa050162.42068442
11Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.08478088
12Nucleotide excision repair_Homo sapiens_hsa034202.01299540
13Basal transcription factors_Homo sapiens_hsa030221.88290503
14Homologous recombination_Homo sapiens_hsa034401.82530056
15RNA degradation_Homo sapiens_hsa030181.70247319
16Mismatch repair_Homo sapiens_hsa034301.69550081
17Folate biosynthesis_Homo sapiens_hsa007901.63245396
18Cardiac muscle contraction_Homo sapiens_hsa042601.47274847
19RNA polymerase_Homo sapiens_hsa030201.45840984
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.38826984
21DNA replication_Homo sapiens_hsa030301.37296469
22Spliceosome_Homo sapiens_hsa030401.30879824
23Sulfur metabolism_Homo sapiens_hsa009201.30812185
24Intestinal immune network for IgA production_Homo sapiens_hsa046721.30318367
25Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.30054754
26Propanoate metabolism_Homo sapiens_hsa006401.28807860
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.26075681
28Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.22051464
29Glutathione metabolism_Homo sapiens_hsa004801.18533769
30Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.14653914
31Rheumatoid arthritis_Homo sapiens_hsa053231.13260085
32Collecting duct acid secretion_Homo sapiens_hsa049661.11538300
33RNA transport_Homo sapiens_hsa030131.10548643
34Asthma_Homo sapiens_hsa053101.08804491
35Pyrimidine metabolism_Homo sapiens_hsa002401.08302036
36Viral carcinogenesis_Homo sapiens_hsa052031.05319108
37Allograft rejection_Homo sapiens_hsa053301.03813311
38Sulfur relay system_Homo sapiens_hsa041221.00123842
39Primary bile acid biosynthesis_Homo sapiens_hsa001200.98179633
40One carbon pool by folate_Homo sapiens_hsa006700.97065806
41Vitamin digestion and absorption_Homo sapiens_hsa049770.95906558
42Autoimmune thyroid disease_Homo sapiens_hsa053200.94899933
43Type I diabetes mellitus_Homo sapiens_hsa049400.90530081
44Drug metabolism - other enzymes_Homo sapiens_hsa009830.89631290
45Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.89259350
46Pyruvate metabolism_Homo sapiens_hsa006200.89231968
47Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.88556232
48Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.88186554
49Steroid biosynthesis_Homo sapiens_hsa001000.86211291
50Non-homologous end-joining_Homo sapiens_hsa034500.85093852
51Graft-versus-host disease_Homo sapiens_hsa053320.84006206
52Fanconi anemia pathway_Homo sapiens_hsa034600.79138474
53Fatty acid degradation_Homo sapiens_hsa000710.78821197
54Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.73096466
55beta-Alanine metabolism_Homo sapiens_hsa004100.70601961
56Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.69703832
57Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.67378738
58Pentose and glucuronate interconversions_Homo sapiens_hsa000400.63322090
59Fatty acid elongation_Homo sapiens_hsa000620.62266949
60Tryptophan metabolism_Homo sapiens_hsa003800.61850095
61Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.61686225
62Chemical carcinogenesis_Homo sapiens_hsa052040.61437938
63Epstein-Barr virus infection_Homo sapiens_hsa051690.61227358
64Carbon metabolism_Homo sapiens_hsa012000.60994459
65Butanoate metabolism_Homo sapiens_hsa006500.60507752
66Transcriptional misregulation in cancer_Homo sapiens_hsa052020.59351065
67Metabolic pathways_Homo sapiens_hsa011000.56303738
68Vibrio cholerae infection_Homo sapiens_hsa051100.55245791
69Selenocompound metabolism_Homo sapiens_hsa004500.55049654
70Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.54794507
71Renin-angiotensin system_Homo sapiens_hsa046140.54685519
72Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.53421070
73Purine metabolism_Homo sapiens_hsa002300.53039123
74Base excision repair_Homo sapiens_hsa034100.48466110
75Regulation of autophagy_Homo sapiens_hsa041400.45347476
76Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.44848972
77Retinol metabolism_Homo sapiens_hsa008300.44665891
78Antigen processing and presentation_Homo sapiens_hsa046120.41041032
79Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.40761339
80Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.38907916
81Pentose phosphate pathway_Homo sapiens_hsa000300.38293540
82Mineral absorption_Homo sapiens_hsa049780.36945335
83Cysteine and methionine metabolism_Homo sapiens_hsa002700.36628715
84Steroid hormone biosynthesis_Homo sapiens_hsa001400.36375928
85Primary immunodeficiency_Homo sapiens_hsa053400.33602770
86Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.32933329
87Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.29835582
88Nitrogen metabolism_Homo sapiens_hsa009100.29780865
89Peroxisome_Homo sapiens_hsa041460.29437913
90N-Glycan biosynthesis_Homo sapiens_hsa005100.27945822
91Fatty acid metabolism_Homo sapiens_hsa012120.27238937
92Maturity onset diabetes of the young_Homo sapiens_hsa049500.26429642
93Phagosome_Homo sapiens_hsa041450.25482370
94Viral myocarditis_Homo sapiens_hsa054160.23959633
95p53 signaling pathway_Homo sapiens_hsa041150.23398162
96Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.21273190
97Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.20451044
98Cyanoamino acid metabolism_Homo sapiens_hsa004600.17513019
99Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.17254020
100Cell cycle_Homo sapiens_hsa041100.14412422

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