CLIC5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the chloride intracellular channel (CLIC) family of chloride ion channels. The encoded protein associates with actin-based cytoskeletal structures and may play a role in multiple processes including hair cell stereocilia formation, myoblast proliferation and glomerular podocyte and endothelial cell maintenance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1glomerular epithelial cell development (GO:0072310)9.77363473
2glomerular basement membrane development (GO:0032836)8.51618294
3surfactant homeostasis (GO:0043129)7.21208951
4skeletal muscle contraction (GO:0003009)7.00821483
5NADH metabolic process (GO:0006734)6.26403683
6chemical homeostasis within a tissue (GO:0048875)5.84573569
7creatine metabolic process (GO:0006600)5.72386640
8response to stimulus involved in regulation of muscle adaptation (GO:0014874)5.62917036
9glomerulus development (GO:0032835)5.54104279
10regulation of cell communication by electrical coupling (GO:0010649)5.32768366
11vascular endothelial growth factor signaling pathway (GO:0038084)5.19337293
12regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)5.05578783
13response to inactivity (GO:0014854)5.04334910
14striated muscle hypertrophy (GO:0014897)4.87768436
15response to muscle activity (GO:0014850)4.71491530
16muscle contraction (GO:0006936)4.67109324
17sarcomere organization (GO:0045214)4.51630442
18positive regulation of p38MAPK cascade (GO:1900745)4.49066068
19lymphangiogenesis (GO:0001946)4.47068282
20bundle of His cell to Purkinje myocyte communication (GO:0086069)4.41907835
21muscle hypertrophy (GO:0014896)4.38934720
22regulation of calcineurin-NFAT signaling cascade (GO:0070884)4.38595364
23regulation of the force of heart contraction (GO:0002026)4.22429549
24muscle system process (GO:0003012)4.21978318
25regulation of striated muscle contraction (GO:0006942)4.20204755
26regulation of p38MAPK cascade (GO:1900744)4.13191254
27striated muscle adaptation (GO:0014888)4.10451186
28skeletal muscle fiber development (GO:0048741)4.05532895
29venous blood vessel morphogenesis (GO:0048845)4.01936821
30adult heart development (GO:0007512)4.00053113
31negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.99074542
32cardiac myofibril assembly (GO:0055003)3.97801572
33coronary vasculature morphogenesis (GO:0060977)3.95619341
34glucan catabolic process (GO:0009251)3.91577001
35regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.91301421
36glycogen catabolic process (GO:0005980)3.86736707
37angiotensin maturation (GO:0002003)3.84704726
38endothelial cell chemotaxis (GO:0035767)3.83417750
39positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.82349573
40cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.78302323
41muscle filament sliding (GO:0030049)3.72162919
42actin-myosin filament sliding (GO:0033275)3.72162919
43muscle fiber development (GO:0048747)3.71834266
44myofibril assembly (GO:0030239)3.71818185
45myotube cell development (GO:0014904)3.71814567
46heart contraction (GO:0060047)3.69896437
47heart process (GO:0003015)3.69896437
48renal filtration (GO:0097205)3.69472246
49lymph vessel development (GO:0001945)3.68724227
50cellular polysaccharide catabolic process (GO:0044247)3.67968591
51fructose metabolic process (GO:0006000)3.66356757
52plasma membrane repair (GO:0001778)3.64882376
53cell migration involved in sprouting angiogenesis (GO:0002042)3.62180533
54cardiac muscle adaptation (GO:0014887)3.58441272
55cardiac muscle hypertrophy in response to stress (GO:0014898)3.58441272
56muscle hypertrophy in response to stress (GO:0003299)3.58441272
57regulation of endothelial cell differentiation (GO:0045601)3.58165238
58skeletal muscle tissue development (GO:0007519)3.49711123
59regulation of skeletal muscle contraction (GO:0014819)3.47942079
60actin-mediated cell contraction (GO:0070252)3.47107561
61regulation of cardiac muscle cell contraction (GO:0086004)3.45311263
62protein localization to endosome (GO:0036010)3.44267968
63regulation of vasculogenesis (GO:2001212)3.43900258
64regulation of calcium ion transmembrane transport (GO:1903169)3.42754544
65regulation of calcium ion transmembrane transporter activity (GO:1901019)3.42754544
66actomyosin structure organization (GO:0031032)3.39074031
67positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.37892592
68retina vasculature morphogenesis in camera-type eye (GO:0061299)3.34206744
69polysaccharide catabolic process (GO:0000272)3.33314822
70regulation of glomerular filtration (GO:0003093)3.31460915
71muscle adaptation (GO:0043500)3.31147366
72carnitine shuttle (GO:0006853)3.30029282
73glucan biosynthetic process (GO:0009250)3.29873633
74glycogen biosynthetic process (GO:0005978)3.29873633
75negative regulation of potassium ion transmembrane transport (GO:1901380)3.29848364
76lung vasculature development (GO:0060426)3.27575218
77epithelial cell differentiation involved in kidney development (GO:0035850)3.27281087
78regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.27201178
79fatty acid transmembrane transport (GO:1902001)3.26736369
80blood vessel maturation (GO:0001955)3.24838156
81striated muscle cell development (GO:0055002)3.24458901
822-oxoglutarate metabolic process (GO:0006103)3.24406708
83muscle atrophy (GO:0014889)3.24207622
84relaxation of muscle (GO:0090075)3.23585659
85regulation of membrane repolarization (GO:0060306)3.23327831
86vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.23119429
87negative regulation of calcium ion transmembrane transport (GO:1903170)3.19608462
88negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.19608462
89regulation of axon guidance (GO:1902667)3.18465002
90regulation of sequestering of triglyceride (GO:0010889)3.17367390
91cardiac muscle cell development (GO:0055013)3.16467163
92cell adhesion mediated by integrin (GO:0033627)3.15851539
93negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.15802593
94tricarboxylic acid cycle (GO:0006099)3.15507064
95positive regulation of vascular permeability (GO:0043117)3.12809533
96actin filament-based movement (GO:0030048)3.12655367
97response to epinephrine (GO:0071871)3.12112061
98ventricular cardiac muscle cell action potential (GO:0086005)3.11697293
99regulation of heart rate (GO:0002027)3.11595220
100regulation of actin filament-based movement (GO:1903115)3.09677339
101epithelial cell-cell adhesion (GO:0090136)3.09643832
102skeletal muscle adaptation (GO:0043501)3.09345039
103regulation of cardioblast differentiation (GO:0051890)3.05638830
104regulation of vascular permeability (GO:0043114)3.05173639
105regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.04138770
106endothelium development (GO:0003158)3.03949261
107patterning of blood vessels (GO:0001569)3.03576726
108regulation of ATP catabolic process (GO:1903289)3.02519164
109regulation of ATPase activity (GO:0043462)3.02519164
110oxaloacetate metabolic process (GO:0006107)3.01935416
111regulation of muscle system process (GO:0090257)3.00499233
112heart trabecula formation (GO:0060347)3.00339237
113morphogenesis of an endothelium (GO:0003159)2.99547070
114endothelial tube morphogenesis (GO:0061154)2.99547070
115regulation of muscle contraction (GO:0006937)2.98989645
116positive regulation of cation channel activity (GO:2001259)2.98903769
117cardiac cell development (GO:0055006)2.98245761
118cardiac muscle contraction (GO:0060048)2.97013341
119cardiac muscle cell action potential (GO:0086001)2.96970794
120muscle cell cellular homeostasis (GO:0046716)2.96893975
121regulation of relaxation of muscle (GO:1901077)2.96637282
122positive regulation of vasculogenesis (GO:2001214)2.96201051
123cellular response to epinephrine stimulus (GO:0071872)2.95700438
124positive regulation of endothelial cell differentiation (GO:0045603)2.93032037
125striated muscle atrophy (GO:0014891)2.89890968
126wound healing, spreading of epidermal cells (GO:0035313)2.86703639
127glomerular filtration (GO:0003094)2.86097763
128regulation of axon extension involved in axon guidance (GO:0048841)2.85552704
129regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.85054492
130blood vessel endothelial cell migration (GO:0043534)2.84332587
131renal system process involved in regulation of blood volume (GO:0001977)2.82631768
132hemidesmosome assembly (GO:0031581)2.81499432
133relaxation of cardiac muscle (GO:0055119)2.76730189
134regulation of endothelial cell chemotaxis (GO:2001026)2.75799355
135cell communication involved in cardiac conduction (GO:0086065)2.74421671
136cardiac muscle tissue morphogenesis (GO:0055008)2.72693271
137negative regulation of axon guidance (GO:1902668)2.65517910
138cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.61870096
139regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.61126220
140dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.61054351
141blood vessel remodeling (GO:0001974)2.59823044
142stress fiber assembly (GO:0043149)2.59768223
143ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.58838648
144muscle tissue morphogenesis (GO:0060415)2.58266569
145mesodermal cell differentiation (GO:0048333)2.58242984
146sprouting angiogenesis (GO:0002040)2.58146092
147striated muscle contraction (GO:0006941)2.57536675
148carnitine transmembrane transport (GO:1902603)2.57432903
149cardiac muscle hypertrophy (GO:0003300)2.57349743
150artery development (GO:0060840)2.56314742
151regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.55444749
152desmosome organization (GO:0002934)2.52856682
153positive regulation of focal adhesion assembly (GO:0051894)2.52467676
154positive regulation of cell junction assembly (GO:1901890)2.52467676
155carnitine transport (GO:0015879)2.52255532
156amino-acid betaine transport (GO:0015838)2.52255532
157sarcoplasmic reticulum calcium ion transport (GO:0070296)2.51118172
158regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.50540522
159glomerular visceral epithelial cell development (GO:0072015)10.8474745

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.92149686
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.63659955
3TRIM28_21343339_ChIP-Seq_HEK293_Human3.39918799
4EZH2_22144423_ChIP-Seq_EOC_Human2.79564000
5* EP300_21415370_ChIP-Seq_HL-1_Mouse2.79335891
6RARG_19884340_ChIP-ChIP_MEFs_Mouse2.77088222
7TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.70632981
8CLOCK_20551151_ChIP-Seq_293T_Human2.67986908
9GATA1_22025678_ChIP-Seq_K562_Human2.57137415
10TP63_17297297_ChIP-ChIP_HaCaT_Human2.56638444
11ESR1_20079471_ChIP-ChIP_T-47D_Human2.48722482
12GATA2_21666600_ChIP-Seq_HMVEC_Human2.48309808
13TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.41805876
14ESR1_21235772_ChIP-Seq_MCF-7_Human2.39562748
15ESR2_21235772_ChIP-Seq_MCF-7_Human2.31400887
16CDX2_19796622_ChIP-Seq_MESCs_Mouse2.23826195
17* TBX20_22080862_ChIP-Seq_HEART_Mouse2.15739018
18* TBX20_22328084_ChIP-Seq_HEART_Mouse2.15739018
19PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.06908138
20PPAR_26484153_Chip-Seq_NCI-H1993_Human1.90173485
21ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.89266778
22IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.85755259
23CDX2_20551321_ChIP-Seq_CACO-2_Human1.84065915
24PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.82812385
25NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.73467716
26TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.70913933
27TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.68644057
28THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.68135579
29ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.61961404
30TCF4_18268006_ChIP-ChIP_LS174T_Human1.60174141
31FOXO3_23340844_ChIP-Seq_DLD1_Human1.57820936
32ZNF217_24962896_ChIP-Seq_MCF-7_Human1.53134005
33NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.52903668
34STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.52851834
35STAT6_21828071_ChIP-Seq_BEAS2B_Human1.51010607
36WT1_19549856_ChIP-ChIP_CCG9911_Human1.50523921
37AHR_22903824_ChIP-Seq_MCF-7_Human1.48471407
38* SOX2_20726797_ChIP-Seq_SW620_Human1.45699201
39TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.45061428
40CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.43919624
41NFIB_24661679_ChIP-Seq_LUNG_Mouse1.43882013
42LXR_22158963_ChIP-Seq_LIVER_Mouse1.39982859
43* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.39595394
44SALL4_18804426_ChIP-ChIP_XEN_Mouse1.37294562
45RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.36723084
46* CJUN_26792858_Chip-Seq_BT549_Human1.36574067
47SOX9_24532713_ChIP-Seq_HFSC_Mouse1.36301622
48SOX2_27498859_Chip-Seq_STOMACH_Mouse1.35066543
49* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.33522053
50KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.31562478
51* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.31367436
52SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.31110520
53DROSHA_22980978_ChIP-Seq_HELA_Human1.30488743
54GATA4_25053715_ChIP-Seq_YYC3_Human1.27937326
55EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.26968460
56ZNF263_19887448_ChIP-Seq_K562_Human1.25404511
57GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23068256
58PPARA_22158963_ChIP-Seq_LIVER_Mouse1.22980598
59FOXA2_19822575_ChIP-Seq_HepG2_Human1.20562624
60SMAD3_21741376_ChIP-Seq_HESCs_Human1.19866522
61ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.17398531
62KDM2B_26808549_Chip-Seq_SUP-B15_Human1.16549663
63GATA1_19941826_ChIP-Seq_K562_Human1.15268176
64GATA4_21415370_ChIP-Seq_HL-1_Mouse1.15140751
65ARNT_22903824_ChIP-Seq_MCF-7_Human1.14213967
66SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.13841656
67GATA2_19941826_ChIP-Seq_K562_Human1.11178142
68ELK3_25401928_ChIP-Seq_HUVEC_Human1.10655463
69* MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.09405305
70* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.09360974
71SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.09132538
72MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.08771334
73RUNX1_27514584_Chip-Seq_MCF-7_Human1.07973585
74SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.07956814
75SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.07956814
76NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.07821239
77RXR_22158963_ChIP-Seq_LIVER_Mouse1.07549726
78SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.07065617
79JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05776177
80PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.05675066
81STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.04906773
82CTCF_27219007_Chip-Seq_Bcells_Human1.03367027
83WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.03003046
84SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.02282184
85* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.01186468
86RACK7_27058665_Chip-Seq_MCF-7_Human1.00506489
87ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.00456353
88MTF2_20144788_ChIP-Seq_MESCs_Mouse0.99594792
89HIF1A_21447827_ChIP-Seq_MCF-7_Human0.97701474
90NRF2_20460467_ChIP-Seq_MEFs_Mouse0.96916232
91NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.96916232
92RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.95657680
93PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.95608841
94GATA1_19941827_ChIP-Seq_MEL_Mouse0.95084966
95RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.94667542
96ISL1_27105846_Chip-Seq_CPCs_Mouse0.94445195
97NR3C1_23031785_ChIP-Seq_PC12_Mouse0.94356587
98KDM2B_26808549_Chip-Seq_K562_Human0.94266438
99KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.92914229
100BCAT_22108803_ChIP-Seq_LS180_Human0.91740476
101* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.90126360
102EZH2_18974828_ChIP-Seq_MESCs_Mouse0.89456260
103RNF2_18974828_ChIP-Seq_MESCs_Mouse0.89456260
104* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.88751523
105SMAD4_21741376_ChIP-Seq_HESCs_Human0.88045043
106EZH2_27294783_Chip-Seq_ESCs_Mouse0.87686334
107CTNNB1_20460455_ChIP-Seq_HCT116_Human0.87275616
108SMAD_19615063_ChIP-ChIP_OVARY_Human0.87185910
109SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86949676
110FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.85858839
111PIAS1_25552417_ChIP-Seq_VCAP_Human0.85799141
112JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85687430
113CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.85047176
114CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.84484778
115GATA6_25053715_ChIP-Seq_YYC3_Human0.83342275
116TP63_23658742_ChIP-Seq_EP156T_Human0.83299875
117MYC_27129775_Chip-Seq_CORNEA_Mouse0.83030298
118P63_26484246_Chip-Seq_KERATINOCYTES_Human0.82427921
119GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.81056243
120GATA1_19941827_ChIP-Seq_MEL86_Mouse0.78548727
121LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.76360721
122SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.75892061
123SMC3_22415368_ChIP-Seq_MEFs_Mouse0.74937063
124RUNX_20019798_ChIP-Seq_JUKART_Human0.72723256
125Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.72414064
126GF1_26923725_Chip-Seq_HPCs_Mouse0.72206697
127FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.70509930
128GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.68472293
129VDR_22108803_ChIP-Seq_LS180_Human0.68430743
130LXR_22292898_ChIP-Seq_THP-1_Human0.68157425

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004084_abnormal_cardiac_muscle4.89221168
2MP0010368_abnormal_lymphatic_system4.18446764
3MP0004036_abnormal_muscle_relaxation3.60742457
4MP0001879_abnormal_lymphatic_vessel3.51788534
5MP0002837_dystrophic_cardiac_calcinosis3.44512449
6MP0004272_abnormal_basement_membrane3.07851283
7MP0000751_myopathy2.93044917
8MP0004215_abnormal_myocardial_fiber2.85753590
9MP0003646_muscle_fatigue2.84131367
10MP0005167_abnormal_blood-brain_barrier2.73040025
11MP0005451_abnormal_body_composition2.64925958
12MP0008775_abnormal_heart_ventricle2.45577341
13MP0005330_cardiomyopathy2.39983024
14MP0001958_emphysema2.39779186
15MP0000749_muscle_degeneration2.39141715
16MP0006138_congestive_heart_failure2.35757282
17MP0002972_abnormal_cardiac_muscle2.28843300
18MP0004130_abnormal_muscle_cell2.25986471
19MP0001544_abnormal_cardiovascular_syste2.24566202
20MP0005385_cardiovascular_system_phenoty2.24566202
21MP0003828_pulmonary_edema2.19763834
22MP0004484_altered_response_of2.16588093
23MP0004782_abnormal_surfactant_physiolog2.14685078
24MP0004087_abnormal_muscle_fiber2.11605935
25MP0005620_abnormal_muscle_contractility2.03168585
26MP0005623_abnormal_meninges_morphology2.01072719
27MP0010630_abnormal_cardiac_muscle1.92211333
28MP0002138_abnormal_hepatobiliary_system1.79983184
29MP0000343_altered_response_to1.66745228
30MP0003566_abnormal_cell_adhesion1.64078102
31MP0000750_abnormal_muscle_regeneration1.62310606
32MP0002106_abnormal_muscle_physiology1.57511036
33MP0000230_abnormal_systemic_arterial1.55784163
34MP0003950_abnormal_plasma_membrane1.53348212
35MP0006036_abnormal_mitochondrial_physio1.52812309
36MP0000747_muscle_weakness1.52437145
37MP0003137_abnormal_impulse_conducting1.49086149
38MP0002108_abnormal_muscle_morphology1.48804330
39MP0004085_abnormal_heartbeat1.43970895
40MP0005165_increased_susceptibility_to1.43918051
41MP0009643_abnormal_urine_homeostasis1.41600025
42MP0000767_abnormal_smooth_muscle1.40409490
43MP0003705_abnormal_hypodermis_morpholog1.39145094
44MP0000537_abnormal_urethra_morphology1.37989571
45MP0004185_abnormal_adipocyte_glucose1.37824825
46MP0002269_muscular_atrophy1.37815692
47MP0004510_myositis1.26904348
48MP0003724_increased_susceptibility_to1.26890000
49MP0002971_abnormal_brown_adipose1.25565964
50MP0005369_muscle_phenotype1.25554230
51MP0002128_abnormal_blood_circulation1.24948739
52MP0005666_abnormal_adipose_tissue1.23514996
53MP0005360_urolithiasis1.21968672
54MP0003191_abnormal_cellular_cholesterol1.21864976
55MP0009384_cardiac_valve_regurgitation1.21460770
56MP0002136_abnormal_kidney_physiology1.21171178
57MP0002332_abnormal_exercise_endurance1.20236899
58MP0000759_abnormal_skeletal_muscle1.16912130
59MP0005266_abnormal_metabolism1.16362774
60MP0005332_abnormal_amino_acid1.14029061
61MP0003279_aneurysm1.11992797
62MP0003091_abnormal_cell_migration1.11118226
63MP0002127_abnormal_cardiovascular_syste1.10600822
64MP0002295_abnormal_pulmonary_circulatio1.10274277
65MP0003941_abnormal_skin_development1.07723536
66MP0001756_abnormal_urination1.05941444
67MP0004145_abnormal_muscle_electrophysio1.05165076
68MP0009780_abnormal_chondrocyte_physiolo1.04881367
69MP0003221_abnormal_cardiomyocyte_apopto1.04694558
70MP0003300_gastrointestinal_ulcer1.04647248
71MP0005388_respiratory_system_phenotype1.04374613
72MP0002133_abnormal_respiratory_system1.04374613
73MP0004043_abnormal_pH_regulation1.02281530
74MP0004233_abnormal_muscle_weight1.01037178
75MP0000266_abnormal_heart_morphology0.96649376
76MP0006054_spinal_hemorrhage0.93925915
77MP0008961_abnormal_basal_metabolism0.93049703
78MP0001614_abnormal_blood_vessel0.92412011
79MP0000013_abnormal_adipose_tissue0.91982776
80MP0002925_abnormal_cardiovascular_devel0.91711690
81MP0004270_analgesia0.91235568
82MP0009840_abnormal_foam_cell0.91161248
83MP0005375_adipose_tissue_phenotype0.89819293
84MP0005595_abnormal_vascular_smooth0.89213419
85MP0000249_abnormal_blood_vessel0.88554738
86MP0005670_abnormal_white_adipose0.86773386
87MP0002135_abnormal_kidney_morphology0.84643618
88MP0003567_abnormal_fetal_cardiomyocyte0.83724223
89MP0001661_extended_life_span0.82143831
90MP0000534_abnormal_ureter_morphology0.81556816
91MP0008995_early_reproductive_senescence0.75843968
92MP0001765_abnormal_ion_homeostasis0.74771442
93MP0008875_abnormal_xenobiotic_pharmacok0.71453580
94MP0001784_abnormal_fluid_regulation0.70356137
95MP0003045_fibrosis0.69918926
96MP0008004_abnormal_stomach_pH0.69915636
97MP0005275_abnormal_skin_tensile0.69637704
98MP0000516_abnormal_urinary_system0.69256301
99MP0005367_renal/urinary_system_phenotyp0.69256301
100MP0005409_darkened_coat_color0.68877010
101MP0003879_abnormal_hair_cell0.68788472
102MP0000733_abnormal_muscle_development0.67909524
103MP0004147_increased_porphyrin_level0.67452806
104MP0000003_abnormal_adipose_tissue0.66072829
105MP0005085_abnormal_gallbladder_physiolo0.65176607
106MP0005187_abnormal_penis_morphology0.64405378
107MP0010234_abnormal_vibrissa_follicle0.64228241
108MP0002822_catalepsy0.64105299
109MP0005166_decreased_susceptibility_to0.62227344
110MP0001666_abnormal_nutrient_absorption0.61763817
111MP0003252_abnormal_bile_duct0.61290990
112MP0005584_abnormal_enzyme/coenzyme_acti0.59957736
113MP0005535_abnormal_body_temperature0.59772060
114MP0002078_abnormal_glucose_homeostasis0.55427159
115MP0009115_abnormal_fat_cell0.54696689
116MP0002118_abnormal_lipid_homeostasis0.50340330
117MP0005334_abnormal_fat_pad0.50042034
118MP0001664_abnormal_digestion0.48158480
119MP0005376_homeostasis/metabolism_phenot0.44165526
120MP0002896_abnormal_bone_mineralization0.41542272
121MP0005365_abnormal_bile_salt0.40216250
122MP0002876_abnormal_thyroid_physiology0.35595332
123MP0003948_abnormal_gas_homeostasis0.34977793
124MP0005319_abnormal_enzyme/_coenzyme0.34570081
125MP0002139_abnormal_hepatobiliary_system0.34504239
126MP0010155_abnormal_intestine_physiology0.34148474
127MP0003656_abnormal_erythrocyte_physiolo0.31641578
128MP0010329_abnormal_lipoprotein_level0.30866069
129MP0003183_abnormal_peptide_metabolism0.28707189

Predicted human phenotypes

RankGene SetZ-score
1Mesangial abnormality (HP:0001966)6.21593890
2Focal segmental glomerulosclerosis (HP:0000097)5.22390969
3Sudden death (HP:0001699)5.15190357
4Right ventricular cardiomyopathy (HP:0011663)4.88009160
5Myopathic facies (HP:0002058)4.81838691
6Ventricular tachycardia (HP:0004756)4.68843601
7Centrally nucleated skeletal muscle fibers (HP:0003687)4.66006822
8Polycythemia (HP:0001901)4.55853107
9Muscle fiber splitting (HP:0003555)4.51664731
10Distal arthrogryposis (HP:0005684)4.46740110
11Hyporeflexia of lower limbs (HP:0002600)4.29798510
12Exercise-induced muscle cramps (HP:0003710)4.25809937
13Glomerulosclerosis (HP:0000096)4.19497482
14Exercise-induced myalgia (HP:0003738)4.19230378
15Hyperactive renin-angiotensin system (HP:0000841)4.05991033
16Calf muscle hypertrophy (HP:0008981)4.01706604
17Rimmed vacuoles (HP:0003805)3.97640101
18Interstitial pulmonary disease (HP:0006530)3.89093398
19Hypoalbuminemia (HP:0003073)3.87244047
20Abnormal albumin level (HP:0012116)3.87244047
21Hematochezia (HP:0002573)3.87213880
22Round ear (HP:0100830)3.78956490
23Muscle hypertrophy of the lower extremities (HP:0008968)3.77247857
24Atrial fibrillation (HP:0005110)3.53946394
25Myoglobinuria (HP:0002913)3.52203792
26Nephritis (HP:0000123)3.50447486
27Ulnar deviation of the wrist (HP:0003049)3.48463998
28Increased connective tissue (HP:0009025)3.41021536
29Difficulty running (HP:0009046)3.32178287
30EMG: neuropathic changes (HP:0003445)3.27503963
31Primary atrial arrhythmia (HP:0001692)3.26828752
32Lipoatrophy (HP:0100578)3.26697748
33Syncope (HP:0001279)3.24540909
34Abnormality of the calf musculature (HP:0001430)3.19556058
35Visceral angiomatosis (HP:0100761)3.17392003
36Supraventricular arrhythmia (HP:0005115)3.12691897
37Supraventricular tachycardia (HP:0004755)3.08893132
38Areflexia of lower limbs (HP:0002522)3.06935236
39Bundle branch block (HP:0011710)2.99155995
40EMG: myopathic abnormalities (HP:0003458)2.98405363
41Hyperkalemia (HP:0002153)2.98077115
42Spontaneous hematomas (HP:0007420)2.95835083
43Abnormality of the left ventricular outflow tract (HP:0011103)2.90794642
44Subaortic stenosis (HP:0001682)2.90794642
45Distal lower limb amyotrophy (HP:0008944)2.90644410
46Dilated cardiomyopathy (HP:0001644)2.90436852
47Stage 5 chronic kidney disease (HP:0003774)2.90219649
48Hemangiomatosis (HP:0007461)2.89878152
49Asymmetric septal hypertrophy (HP:0001670)2.86884082
50Lymphangioma (HP:0100764)2.79384593
51Rapidly progressive (HP:0003678)2.78993085
52Calcaneovalgus deformity (HP:0001848)2.77321367
53Palpitations (HP:0001962)2.75803938
54Abnormality of the nasal mucosa (HP:0000433)2.75077096
55Absent phalangeal crease (HP:0006109)2.70641437
56Prolonged QT interval (HP:0001657)2.67191192
57Bulbar palsy (HP:0001283)2.61894389
58Rhabdomyolysis (HP:0003201)2.59735681
59Cerebral hemorrhage (HP:0001342)2.58376556
60Esophageal varix (HP:0002040)2.57609880
61Broad metatarsal (HP:0001783)2.57414207
62Muscle fiber inclusion bodies (HP:0100299)2.52852817
63Potter facies (HP:0002009)2.51102617
64Facial shape deformation (HP:0011334)2.51102617
65Cavernous hemangioma (HP:0001048)2.50698892
66Glomerulonephritis (HP:0000099)2.49418421
67Heart block (HP:0012722)2.49416632
68Abnormality of the foot musculature (HP:0001436)2.48299756
69Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.45722168
70Ventricular arrhythmia (HP:0004308)2.44050880
71Tubulointerstitial fibrosis (HP:0005576)2.40899631
72Deformed tarsal bones (HP:0008119)2.40784929
73Type 1 muscle fiber predominance (HP:0003803)2.36017532
74Abnormal atrioventricular conduction (HP:0005150)2.35557852
75Difficulty climbing stairs (HP:0003551)2.35494202
76Atrioventricular block (HP:0001678)2.35432267
77Scapular winging (HP:0003691)2.30427859
78Abnormality of renin-angiotensin system (HP:0000847)2.28376148
79Malignant hyperthermia (HP:0002047)2.28147433
80Abnormality of chloride homeostasis (HP:0011422)2.27643349
81Hypokalemic alkalosis (HP:0001949)2.26431380
82Foot dorsiflexor weakness (HP:0009027)2.26188225
83Ragged-red muscle fibers (HP:0003200)2.24335828
84Myotonia (HP:0002486)2.24123320
85Gowers sign (HP:0003391)2.22687852
86Increased variability in muscle fiber diameter (HP:0003557)2.22481825
87Hypoproteinemia (HP:0003075)2.22453745
88Limb-girdle muscle atrophy (HP:0003797)2.19945042
89Hyperaldosteronism (HP:0000859)2.18817211
90Abnormal finger flexion creases (HP:0006143)2.18265549
91Abnormality of skeletal muscle fiber size (HP:0012084)2.14919155
92Distal lower limb muscle weakness (HP:0009053)2.11290543
93Muscle stiffness (HP:0003552)2.10409849
94Mildly elevated creatine phosphokinase (HP:0008180)2.09475117
95Tubular atrophy (HP:0000092)2.09438081
96Lower limb amyotrophy (HP:0007210)2.08622330
97Muscular dystrophy (HP:0003560)2.07538431
98Tachypnea (HP:0002789)2.06865767
99Hydroxyprolinuria (HP:0003080)2.03091164
100Abnormality of proline metabolism (HP:0010907)2.03091164
101Weak cry (HP:0001612)2.01610133
102Proximal amyotrophy (HP:0007126)2.01476940
103Nemaline bodies (HP:0003798)2.00788926
104Generalized muscle weakness (HP:0003324)1.99309304
105Hypoplastic left heart (HP:0004383)1.99169194
106Nonprogressive disorder (HP:0003680)1.99084307
107Rectal prolapse (HP:0002035)1.98448348
108Ketoacidosis (HP:0001993)1.96347167
109Ventricular fibrillation (HP:0001663)1.95905691
110Spinal rigidity (HP:0003306)1.95496140
111Aneurysm (HP:0002617)1.94247555
112Cerebral aneurysm (HP:0004944)1.93624640
113Hypoglycemic coma (HP:0001325)1.93405221
114Respiratory distress (HP:0002098)1.91029185
115Decreased circulating renin level (HP:0003351)1.89042335
116Gout (HP:0001997)1.88558187
117Neonatal respiratory distress (HP:0002643)1.87882362
118Renal salt wasting (HP:0000127)1.87876447
119Aortic aneurysm (HP:0004942)1.87304546
120Slender build (HP:0001533)1.86866937
121Facial diplegia (HP:0001349)1.86272819
122Nephrotic syndrome (HP:0000100)1.85592083
123Neck muscle weakness (HP:0000467)1.84982101
124Abnormality of potassium homeostasis (HP:0011042)1.82542529
125Hematuria (HP:0000790)1.82212532
126Progressive muscle weakness (HP:0003323)1.79611680
127Frequent falls (HP:0002359)1.79188844
128Abnormality of the neuromuscular junction (HP:0003398)1.79088650
129Fatigable weakness (HP:0003473)1.79088650
130Waddling gait (HP:0002515)1.78046370
131Abnormality of the shoulder girdle musculature (HP:0001435)1.77155608
132Hip contracture (HP:0003273)1.75541441
133Steppage gait (HP:0003376)1.74250109
134Abnormal EKG (HP:0003115)1.70495722
135Fetal akinesia sequence (HP:0001989)1.69796792
136Respiratory insufficiency due to muscle weakness (HP:0002747)1.63174779
137Hyperuricemia (HP:0002149)1.58479938
138Increased purine levels (HP:0004368)1.58479938
139Left ventricular hypertrophy (HP:0001712)1.55397421
140Sudden cardiac death (HP:0001645)1.53005087
141Abnormality of glutamine family amino acid metabolism (HP:0010902)1.51120690
142Abnormality of the calcaneus (HP:0008364)1.49437698
143Palmoplantar keratoderma (HP:0000982)1.47892089
144Increased muscle lipid content (HP:0009058)1.47851336
145Oligomenorrhea (HP:0000876)1.47541589
146Toxemia of pregnancy (HP:0100603)1.45059578
147Increased intramyocellular lipid droplets (HP:0012240)1.44498538

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE16.25312297
2TTN3.69275976
3MYLK3.38002794
4TGFBR23.17477150
5EPHB22.92211502
6OBSCN2.87188629
7WNK42.41166084
8LMTK22.40219748
9KDR2.39132936
10TRIB32.30839857
11PHKG22.24207223
12PHKG12.24207223
13PIK3CG2.12313421
14DMPK2.11172569
15RIPK11.97683831
16PAK41.84963115
17PDK41.80002484
18PDK31.80002484
19EPHB11.77273958
20PDK21.58840361
21PDGFRA1.44096925
22STK391.42233019
23FGFR41.40113156
24PIK3CA1.37676971
25LRRK21.34790838
26PKN21.34649235
27MAP2K31.32946687
28TGFBR11.31435790
29FER1.30181044
30MAP3K71.30172187
31LATS11.23617567
32MST41.23229110
33PTK61.21501595
34ERN11.20100874
35STK241.17636523
36MAP3K31.17289680
37OXSR11.12908721
38PRKD11.08367403
39NME11.01633557
40BCKDK0.97910261
41FGFR30.92992197
42ROCK10.92471074
43NEK90.90870550
44GRK10.85603929
45LIMK10.84167729
46CAMK2G0.83837452
47PRKG20.83190315
48INSRR0.82700154
49MAPK70.82547257
50FRK0.80686916
51STK100.80205520
52MARK10.79729808
53EEF2K0.78482267
54FGFR20.78183697
55PAK30.76679998
56PINK10.76604037
57PRPF4B0.73769222
58PRKAA20.73630298
59NEK10.73573798
60ILK0.72453942
61JAK10.71141335
62PDPK10.70890525
63TRPM70.70439061
64MAP2K40.69988069
65MAPK120.68396682
66MAP3K60.67428945
67PDGFRB0.67100736
68AKT30.65225253
69NLK0.65034882
70ACVR1B0.64145805
71PTK2B0.64107612
72TYK20.63520785
73MAP2K60.63336269
74MST1R0.63192176
75GRK70.62812935
76EPHA30.60305616
77MAPK40.59634968
78PRKCH0.59190238
79DYRK1B0.58867578
80CAMK1D0.57810999
81CSK0.57805919
82CAMK2A0.56148660
83ERBB30.55649986
84PRKG10.54208749
85STK38L0.53746054
86MAPK110.53689528
87TBK10.53413389
88GSK3A0.53303722
89PRKAA10.50705887
90WNK10.49599103
91MAP2K10.49263760
92SGK30.48773350
93MAPKAPK30.47709999
94SGK20.47622094
95RPS6KC10.47373113
96RPS6KL10.47373113
97KSR20.47356215
98CAMK10.44850844
99SIK10.44153564
100KIT0.43458088
101PRKCE0.43285977
102CAMK1G0.42755480
103MOS0.41146458
104MAP3K10.40653502
105MAP3K130.39449034
106PRKACA0.39313583
107PTK20.39102362
108EPHA20.38987350
109RPS6KA60.38983452
110MET0.38628028
111CAMK40.38304198
112CAMK2D0.37833212
113LATS20.36667088
114ROCK20.36614819
115DAPK20.36471470
116MAP2K20.35078242
117MARK20.34955914
118JAK20.33476477
119MAP3K20.33094753
120CAMK2B0.32768017
121RPS6KA20.32330914
122EGFR0.31602147
123CDC42BPA0.31339750
124ZAP700.30698873
125PDK10.30479386
126MAP3K100.30105658
127AKT20.29106403
128MUSK0.28381460
129PKN10.28147110
130PRKACB0.27940250
131ICK0.27042003
132PRKACG0.26519674
133RPS6KA30.26329344
134SGK2230.26138627
135SGK4940.26138627
136SRC0.25313243
137SGK10.24466606
138RPS6KA10.23761063
139MAP3K50.23523838
140BLK0.22309233

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.61416006
2Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.99512071
3Dilated cardiomyopathy_Homo sapiens_hsa054142.89469884
4Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.64115496
5ECM-receptor interaction_Homo sapiens_hsa045122.52267731
6Renin-angiotensin system_Homo sapiens_hsa046142.41994203
7Fatty acid degradation_Homo sapiens_hsa000712.37245516
82-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.29706822
9Propanoate metabolism_Homo sapiens_hsa006402.16080040
10Focal adhesion_Homo sapiens_hsa045101.95265365
11Circadian rhythm_Homo sapiens_hsa047101.91974571
12Cardiac muscle contraction_Homo sapiens_hsa042601.79032334
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.66174967
14Fructose and mannose metabolism_Homo sapiens_hsa000511.58189911
15Fatty acid metabolism_Homo sapiens_hsa012121.57365991
16Adherens junction_Homo sapiens_hsa045201.57078573
17Phenylalanine metabolism_Homo sapiens_hsa003601.57007384
18AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.55054437
19Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.51245079
20Viral myocarditis_Homo sapiens_hsa054161.50598607
21Amoebiasis_Homo sapiens_hsa051461.49691282
22Protein digestion and absorption_Homo sapiens_hsa049741.49500042
23Small cell lung cancer_Homo sapiens_hsa052221.48110188
24Tight junction_Homo sapiens_hsa045301.42771149
25Caffeine metabolism_Homo sapiens_hsa002321.42036473
26Leukocyte transendothelial migration_Homo sapiens_hsa046701.37838124
27Mineral absorption_Homo sapiens_hsa049781.37819129
28Histidine metabolism_Homo sapiens_hsa003401.32549808
29PPAR signaling pathway_Homo sapiens_hsa033201.31715142
30Cyanoamino acid metabolism_Homo sapiens_hsa004601.31132741
31Carbon metabolism_Homo sapiens_hsa012001.20306391
32Insulin resistance_Homo sapiens_hsa049311.12693510
33Starch and sucrose metabolism_Homo sapiens_hsa005001.12626067
34Pentose phosphate pathway_Homo sapiens_hsa000301.10749017
35Tryptophan metabolism_Homo sapiens_hsa003801.08579358
36Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.02678495
37Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.00390254
38Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.00135810
39Adipocytokine signaling pathway_Homo sapiens_hsa049200.99844855
40Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.97730811
41Fat digestion and absorption_Homo sapiens_hsa049750.97141775
42Vascular smooth muscle contraction_Homo sapiens_hsa042700.96973270
43Renin secretion_Homo sapiens_hsa049240.95395341
44Pyruvate metabolism_Homo sapiens_hsa006200.94865520
45cGMP-PKG signaling pathway_Homo sapiens_hsa040220.93464953
46Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.90418645
47Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.90282402
48Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.90024420
49Regulation of actin cytoskeleton_Homo sapiens_hsa048100.88369081
50Bile secretion_Homo sapiens_hsa049760.87918072
51Proteoglycans in cancer_Homo sapiens_hsa052050.87305181
52Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.83615326
53Platelet activation_Homo sapiens_hsa046110.82158457
54Nitrogen metabolism_Homo sapiens_hsa009100.81954517
55Axon guidance_Homo sapiens_hsa043600.81171602
56Renal cell carcinoma_Homo sapiens_hsa052110.78672500
57VEGF signaling pathway_Homo sapiens_hsa043700.77034355
58Gastric acid secretion_Homo sapiens_hsa049710.75594645
59Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.75035226
60GnRH signaling pathway_Homo sapiens_hsa049120.74034683
61Rap1 signaling pathway_Homo sapiens_hsa040150.73781916
62HIF-1 signaling pathway_Homo sapiens_hsa040660.71831275
63Toxoplasmosis_Homo sapiens_hsa051450.70767815
64Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.67786243
65Dorso-ventral axis formation_Homo sapiens_hsa043200.67578514
66Linoleic acid metabolism_Homo sapiens_hsa005910.67227511
67Fatty acid biosynthesis_Homo sapiens_hsa000610.66736491
68Alzheimers disease_Homo sapiens_hsa050100.65082605
69Parkinsons disease_Homo sapiens_hsa050120.64004805
70Butanoate metabolism_Homo sapiens_hsa006500.63616298
71Insulin signaling pathway_Homo sapiens_hsa049100.63613750
72Sulfur metabolism_Homo sapiens_hsa009200.63046416
73Lysine degradation_Homo sapiens_hsa003100.62097379
74alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.61814730
75Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.59821107
76Galactose metabolism_Homo sapiens_hsa000520.59398260
77Bladder cancer_Homo sapiens_hsa052190.59173939
78beta-Alanine metabolism_Homo sapiens_hsa004100.58856934
79PI3K-Akt signaling pathway_Homo sapiens_hsa041510.58350091
80Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.58217532
81AMPK signaling pathway_Homo sapiens_hsa041520.57576559
82Biosynthesis of amino acids_Homo sapiens_hsa012300.57415975
83Fatty acid elongation_Homo sapiens_hsa000620.56942957
84Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.56707127
85Tyrosine metabolism_Homo sapiens_hsa003500.55776540
86Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.55106794
87Carbohydrate digestion and absorption_Homo sapiens_hsa049730.53373041
88Oxidative phosphorylation_Homo sapiens_hsa001900.51922692
89Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.51676326
90Glucagon signaling pathway_Homo sapiens_hsa049220.51448752
91Insulin secretion_Homo sapiens_hsa049110.51319815
92Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.50534234
93Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.49726026
94Oxytocin signaling pathway_Homo sapiens_hsa049210.49553846
95Arginine biosynthesis_Homo sapiens_hsa002200.49463767
96Salmonella infection_Homo sapiens_hsa051320.47110584
97ABC transporters_Homo sapiens_hsa020100.46726031
98Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.46550092
99Vitamin digestion and absorption_Homo sapiens_hsa049770.45608718
100Pathways in cancer_Homo sapiens_hsa052000.44756136
101Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.44507711
102Long-term potentiation_Homo sapiens_hsa047200.42197502
103Hippo signaling pathway_Homo sapiens_hsa043900.41933109
104Salivary secretion_Homo sapiens_hsa049700.41006869
105Peroxisome_Homo sapiens_hsa041460.40172510
106Arginine and proline metabolism_Homo sapiens_hsa003300.39372049
107Pertussis_Homo sapiens_hsa051330.39259036
108Pancreatic cancer_Homo sapiens_hsa052120.39074869
109cAMP signaling pathway_Homo sapiens_hsa040240.39008899
110Glycerophospholipid metabolism_Homo sapiens_hsa005640.38593318
111Thyroid hormone synthesis_Homo sapiens_hsa049180.37344916
112Thyroid hormone signaling pathway_Homo sapiens_hsa049190.36914412
113Calcium signaling pathway_Homo sapiens_hsa040200.36684109
114Endocytosis_Homo sapiens_hsa041440.36392875
115Glycerolipid metabolism_Homo sapiens_hsa005610.36079200
116FoxO signaling pathway_Homo sapiens_hsa040680.35621748
117Gap junction_Homo sapiens_hsa045400.34002992
118Pancreatic secretion_Homo sapiens_hsa049720.33961997
119Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.33383442
120Longevity regulating pathway - mammal_Homo sapiens_hsa042110.32662289
121Ovarian steroidogenesis_Homo sapiens_hsa049130.32004070
122Aldosterone synthesis and secretion_Homo sapiens_hsa049250.31920758
123Type II diabetes mellitus_Homo sapiens_hsa049300.31607600
124Pentose and glucuronate interconversions_Homo sapiens_hsa000400.31380688
125Arachidonic acid metabolism_Homo sapiens_hsa005900.24961003
126Circadian entrainment_Homo sapiens_hsa047130.21725604
127Amphetamine addiction_Homo sapiens_hsa050310.20622275

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