CLIC6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the chloride intracellular channel family of proteins. The gene is part of a large triplicated region found on chromosomes 1, 6, and 21. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axoneme assembly (GO:0035082)9.14390936
2membrane repolarization during action potential (GO:0086011)8.84929217
3left/right pattern formation (GO:0060972)8.69429329
4potassium ion export (GO:0071435)7.13268223
5regulation of cilium movement (GO:0003352)6.93462266
6left/right axis specification (GO:0070986)6.25486862
7ventricular system development (GO:0021591)6.23593585
8intraciliary transport (GO:0042073)6.13206781
9membrane repolarization (GO:0086009)6.12374935
10regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)6.04218319
11vitamin transmembrane transport (GO:0035461)5.98848702
12regulation of heart rate by cardiac conduction (GO:0086091)5.80881590
13ventricular cardiac muscle cell action potential (GO:0086005)5.74073148
14diterpenoid biosynthetic process (GO:0016102)5.59629911
15xenobiotic catabolic process (GO:0042178)5.58942911
16microtubule bundle formation (GO:0001578)5.47952390
17cilium organization (GO:0044782)5.31969917
18tongue development (GO:0043586)5.24509121
19cilium assembly (GO:0042384)5.15526334
20potassium ion import (GO:0010107)5.10797994
21response to nitrosative stress (GO:0051409)5.00643590
22establishment of epithelial cell polarity (GO:0090162)4.98382893
23negative regulation of humoral immune response (GO:0002921)4.88074155
24cardiac conduction (GO:0061337)4.84925304
25pyrimidine-containing compound transmembrane transport (GO:0072531)4.71513083
26lung epithelium development (GO:0060428)4.63778202
27response to xenobiotic stimulus (GO:0009410)4.52500291
28glomerular epithelial cell development (GO:0072310)4.46961532
29sperm capacitation (GO:0048240)4.39469432
30phenylpropanoid metabolic process (GO:0009698)4.35688239
31tolerance induction (GO:0002507)4.35636109
32regulation of cardioblast proliferation (GO:0003264)4.31794650
33regulation of secondary heart field cardioblast proliferation (GO:0003266)4.31794650
34microtubule-based movement (GO:0007018)4.31518237
35centriole assembly (GO:0098534)4.29499385
36regulation of interleukin-13 production (GO:0032656)4.26665966
37protein localization to cilium (GO:0061512)4.25320075
38regulation of interleukin-5 production (GO:0032674)4.24283311
39cellular component assembly involved in morphogenesis (GO:0010927)4.13035688
40negative regulation of B cell mediated immunity (GO:0002713)4.08723113
41negative regulation of immunoglobulin mediated immune response (GO:0002890)4.08723113
42negative regulation of T cell differentiation in thymus (GO:0033085)4.05491414
43cilium morphogenesis (GO:0060271)3.97686388
44regulation of microtubule-based movement (GO:0060632)3.97615571
45antibacterial humoral response (GO:0019731)3.95649304
46terpenoid biosynthetic process (GO:0016114)3.91944754
47surfactant homeostasis (GO:0043129)3.91834629
48bundle of His cell to Purkinje myocyte communication (GO:0086069)3.90502813
49calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.88002934
50regulation of membrane repolarization (GO:0060306)3.87416689
51cardiac muscle cell action potential involved in contraction (GO:0086002)3.84058345
52regulation of germinal center formation (GO:0002634)3.83824575
53retinoic acid metabolic process (GO:0042573)3.83072527
54dorsal/ventral axis specification (GO:0009950)3.79733881
55cell projection assembly (GO:0030031)3.75291261
56apical protein localization (GO:0045176)3.69393890
57nucleoside diphosphate phosphorylation (GO:0006165)3.67767358
58establishment of monopolar cell polarity (GO:0061162)3.67618165
59establishment or maintenance of monopolar cell polarity (GO:0061339)3.67618165
60lateral ventricle development (GO:0021670)3.67122793
61cardiac muscle cell action potential (GO:0086001)3.63787009
62antimicrobial humoral response (GO:0019730)3.62794472
63regulation of cardioblast differentiation (GO:0051890)3.60721672
64one-carbon compound transport (GO:0019755)3.57690923
65protein retention in ER lumen (GO:0006621)3.54237437
66establishment of planar polarity (GO:0001736)3.52287901
67establishment of tissue polarity (GO:0007164)3.52287901
68lateral sprouting from an epithelium (GO:0060601)3.48182170
69cellular copper ion homeostasis (GO:0006878)3.47573940
70tight junction assembly (GO:0070830)3.45203459
71regulation of potassium ion transmembrane transporter activity (GO:1901016)3.44268634
72regulation of chemokine secretion (GO:0090196)3.43076701
73embryonic foregut morphogenesis (GO:0048617)3.38944993
74positive regulation of tolerance induction (GO:0002645)3.38846442
75maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.38508154
76primary alcohol metabolic process (GO:0034308)3.37746432
77hypotonic response (GO:0006971)3.34865271
78membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.31343639
79multicellular organismal water homeostasis (GO:0050891)3.31199050
80positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.28594013
81glutathione derivative metabolic process (GO:1901685)3.28207559
82glutathione derivative biosynthetic process (GO:1901687)3.28207559
83retinol metabolic process (GO:0042572)3.25903871
84cytoplasmic microtubule organization (GO:0031122)3.23780408
85multicellular organismal signaling (GO:0035637)3.21593111
86relaxation of cardiac muscle (GO:0055119)3.21094451
87bicarbonate transport (GO:0015701)3.20198725
88hemidesmosome assembly (GO:0031581)3.16440606
89negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)3.15189792
90positive regulation of smoothened signaling pathway (GO:0045880)3.14698565
91sensory perception of smell (GO:0007608)3.06722362
92lung lobe morphogenesis (GO:0060463)3.05793131
93hepatocyte apoptotic process (GO:0097284)3.05265468
94cytoskeletal anchoring at plasma membrane (GO:0007016)3.04958477
95regulation of potassium ion transmembrane transport (GO:1901379)3.04200207
96receptor catabolic process (GO:0032801)3.03448746
97negative regulation of inclusion body assembly (GO:0090084)3.02828718
98L-serine transport (GO:0015825)3.01963867
99vitamin A metabolic process (GO:0006776)3.01473931
100axonemal dynein complex assembly (GO:0070286)20.1156422
101regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.98940996
102dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.97916670
103ethanol oxidation (GO:0006069)2.97610173
104uronic acid metabolic process (GO:0006063)2.96529651
105glucuronate metabolic process (GO:0019585)2.96529651
106regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.91253330
107renal absorption (GO:0070293)2.90368399
108determination of left/right symmetry (GO:0007368)2.90190815
109endocardial cushion morphogenesis (GO:0003203)2.89684538
110exogenous drug catabolic process (GO:0042738)2.89267799
111establishment of apical/basal cell polarity (GO:0035089)2.88168896
112digestion (GO:0007586)2.87648667
113regulation of hippo signaling (GO:0035330)2.85542404
114intestinal epithelial cell development (GO:0060576)2.83746519
115glial cell proliferation (GO:0014009)2.83160519
116maintenance of gastrointestinal epithelium (GO:0030277)2.82984454
117cellular glucuronidation (GO:0052695)2.81653948
118water homeostasis (GO:0030104)2.80952323
119negative regulation of chondrocyte differentiation (GO:0032331)2.80234801
120determination of bilateral symmetry (GO:0009855)2.79902063
121cell-cell junction assembly (GO:0007043)2.76867073
122regulation of apoptotic cell clearance (GO:2000425)2.76113538
123specification of symmetry (GO:0009799)2.76009624
124sodium ion homeostasis (GO:0055078)2.72888121
125dosage compensation (GO:0007549)2.71676996
126negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.71620657
127progesterone metabolic process (GO:0042448)2.71158043
128regulation of phospholipase A2 activity (GO:0032429)2.70438998
129epithelial cell differentiation involved in prostate gland development (GO:0060742)2.70364212
130hormone catabolic process (GO:0042447)2.69286586
131O-glycan processing (GO:0016266)2.69104984
132vitamin transport (GO:0051180)2.68891499
133asymmetric protein localization (GO:0008105)2.68253699
134regulation of skeletal muscle contraction (GO:0014819)2.68159612
135hydrogen peroxide biosynthetic process (GO:0050665)2.68077272
136regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 2.68042175
137phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.67782841
138polyol transport (GO:0015791)2.67298247
139establishment or maintenance of bipolar cell polarity (GO:0061245)2.67293599
140establishment or maintenance of apical/basal cell polarity (GO:0035088)2.67293599
141ethanol metabolic process (GO:0006067)2.66970739
142digestive system process (GO:0022600)2.64941453
143primary alcohol catabolic process (GO:0034310)2.64302060
144outer ear morphogenesis (GO:0042473)2.64111128
145excretion (GO:0007588)2.63184527
146renal system development (GO:0072001)2.63168029
147regulation of transforming growth factor beta1 production (GO:0032908)2.63087194
148mesodermal cell differentiation (GO:0048333)2.62837175
149epithelial structure maintenance (GO:0010669)2.62562504
150positive regulation of digestive system process (GO:0060456)2.61107616
151establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.60940758
152mesenchyme morphogenesis (GO:0072132)2.59761263
153regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.59366147
154retinal metabolic process (GO:0042574)2.59190470
155positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.58843149
156hippo signaling (GO:0035329)2.57171051
157regulation of transforming growth factor beta2 production (GO:0032909)2.56493194
158negative regulation of cell fate specification (GO:0009996)2.56461256
159chemical homeostasis within a tissue (GO:0048875)2.56147000
160ear development (GO:0043583)2.55622611
161regulation of tolerance induction (GO:0002643)2.54650180
162polarized epithelial cell differentiation (GO:0030859)2.54436909
163epithelial cell-cell adhesion (GO:0090136)2.54236592
164notochord development (GO:0030903)2.53838694
165cardiovascular system development (GO:0072358)2.52562564
166exocrine pancreas development (GO:0031017)2.50821656
167lung vasculature development (GO:0060426)2.50178649
168regulation of cell fate specification (GO:0042659)2.50061831
169phosphatidylcholine biosynthetic process (GO:0006656)2.49415878
170thrombin receptor signaling pathway (GO:0070493)2.48956896
171oligosaccharide biosynthetic process (GO:0009312)2.47410668
172protein O-linked glycosylation (GO:0006493)2.47062870
173regulation of autophagic vacuole assembly (GO:2000785)2.46775388
174smoothened signaling pathway (GO:0007224)2.44030342
175microtubule depolymerization (GO:0007019)2.41989001
176centriole replication (GO:0007099)2.40549725
177carnitine metabolic process (GO:0009437)2.38517528
178microtubule polymerization or depolymerization (GO:0031109)2.37254840
179iron ion import (GO:0097286)2.35348885
180microtubule-based process (GO:0007017)2.35000606
181cilium or flagellum-dependent cell motility (GO:0001539)16.5878868
182cilium movement (GO:0003341)15.0765753
183motile cilium assembly (GO:0044458)13.6250286
184epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)13.5245459
185epithelial cilium movement (GO:0003351)13.2713411

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.73327196
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.33044713
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.89836705
4TRIM28_21343339_ChIP-Seq_HEK293_Human3.06810772
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.01010212
6* SOX2_27498859_Chip-Seq_STOMACH_Mouse2.76415861
7RARG_19884340_ChIP-ChIP_MEFs_Mouse2.71274012
8ESR1_21235772_ChIP-Seq_MCF-7_Human2.56657547
9CLOCK_20551151_ChIP-Seq_293T_Human2.53407644
10ZNF217_24962896_ChIP-Seq_MCF-7_Human2.50675506
11ESR2_21235772_ChIP-Seq_MCF-7_Human2.47395725
12ESR1_20079471_ChIP-ChIP_T-47D_Human2.36916865
13ESR1_15608294_ChIP-ChIP_MCF-7_Human2.35518160
14TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.33869980
15AHR_22903824_ChIP-Seq_MCF-7_Human2.23050445
16ZNF263_19887448_ChIP-Seq_K562_Human2.22714916
17SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.15746983
18FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.09907742
19SOX2_20726797_ChIP-Seq_SW620_Human2.09732824
20CDX2_20551321_ChIP-Seq_CACO-2_Human2.01830881
21KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.98576777
22KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.98576777
23KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.98576777
24CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.96446513
25GATA4_25053715_ChIP-Seq_YYC3_Human1.92828859
26PPAR_26484153_Chip-Seq_NCI-H1993_Human1.90978437
27ARNT_22903824_ChIP-Seq_MCF-7_Human1.89160641
28STAT6_21828071_ChIP-Seq_BEAS2B_Human1.86682765
29PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.85826594
30RUNX1_27514584_Chip-Seq_MCF-7_Human1.81249952
31BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.80402501
32* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.70311028
33PIAS1_25552417_ChIP-Seq_VCAP_Human1.68042470
34* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.62995994
35NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.61718130
36FOXO3_23340844_ChIP-Seq_DLD1_Human1.60467346
37SOX9_24532713_ChIP-Seq_HFSC_Mouse1.60258520
38ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.58279614
39KLF5_25053715_ChIP-Seq_YYC3_Human1.57749242
40GATA6_25053715_ChIP-Seq_YYC3_Human1.57317849
41EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.54597403
42SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.51016615
43GATA3_24758297_ChIP-Seq_MCF-7_Human1.48095269
44KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.41496085
45KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.41405061
46PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.40645669
47PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.39592830
48EP300_21415370_ChIP-Seq_HL-1_Mouse1.38489108
49ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.38419655
50NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.38327958
51P63_26484246_Chip-Seq_KERATINOCYTES_Human1.38099138
52FOXM1_26456572_ChIP-Seq_MCF-7_Human1.36645387
53TCF4_18268006_ChIP-ChIP_LS174T_Human1.31032291
54RACK7_27058665_Chip-Seq_MCF-7_Human1.26364195
55NR3C1_21868756_ChIP-Seq_MCF10A_Human1.26247403
56STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.25979827
57RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.25152181
58RAD21_21589869_ChIP-Seq_MESCs_Mouse1.24944355
59GATA2_21666600_ChIP-Seq_HMVEC_Human1.24820517
60SMC4_20622854_ChIP-Seq_HELA_Human1.22532294
61TP63_22573176_ChIP-Seq_HFKS_Human1.19828613
62VDR_22108803_ChIP-Seq_LS180_Human1.17685522
63FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.17363515
64ETV1_20927104_ChIP-Seq_GIST48_Human1.15935568
65CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.15701275
66DROSHA_22980978_ChIP-Seq_HELA_Human1.15582545
67* STAT1_20625510_ChIP-Seq_HELA_Human1.14663848
68* ISL1_27105846_Chip-Seq_CPCs_Mouse1.13727169
69AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.13719386
70CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.13267881
71FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.12493216
72WT1_25993318_ChIP-Seq_PODOCYTE_Human1.12108332
73* TP53_18474530_ChIP-ChIP_U2OS_Human1.11187907
74SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.10939168
75SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.10939168
76ZFP281_27345836_Chip-Seq_ESCs_Mouse1.10209225
77PHF8_20622853_ChIP-Seq_HELA_Human1.09978774
78SMAD3_21741376_ChIP-Seq_HESCs_Human1.09677675
79* HIF1A_21447827_ChIP-Seq_MCF-7_Human1.08689013
80SMRT_27268052_Chip-Seq_Bcells_Human1.08208816
81ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.08191833
82PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.08146387
83GATA1_19941826_ChIP-Seq_K562_Human1.07828109
84HNFA_21074721_ChIP-Seq_CACO-2_Human1.07515436
85WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.07425947
86CDX2_19796622_ChIP-Seq_MESCs_Mouse1.07262730
87CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.06211294
88SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.05288460
89GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04621409
90SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.03913300
91* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.03807316
92* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.03807316
93FOXA2_19822575_ChIP-Seq_HepG2_Human1.03394276
94ERG_21242973_ChIP-ChIP_JURKAT_Human1.01705411
95STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.01596569
96LXR_22158963_ChIP-Seq_LIVER_Mouse1.01195073
97CTCF_27219007_Chip-Seq_Bcells_Human0.97739042
98SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.97426751
99NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.96629205
100TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.95995827
101PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.95454823
102TDRD3_21172665_ChIP-Seq_MCF-7_Human0.95417766
103POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.95131688
104* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.94605180
105SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.94552341
106* KDM2B_26808549_Chip-Seq_K562_Human0.94475783
107BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.94273022
108FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.94185489
109CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.93622583
110NFYA_21822215_ChIP-Seq_K562_Human0.93447885
111CREB1_26743006_Chip-Seq_LNCaP_Human0.92954758
112ZFP281_18757296_ChIP-ChIP_E14_Mouse0.92672817
113RBPJ_21746931_ChIP-Seq_IB4_Human0.92566334
114GATA6_21074721_ChIP-Seq_CACO-2_Human0.92193078
115* TP63_23658742_ChIP-Seq_EP156T_Human0.92014917
116GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.91321756
117ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.90695499
118CJUN_26792858_Chip-Seq_BT549_Human0.90290489
119* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.89997320
120TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.89804909
121* FOXA1_25552417_ChIP-Seq_VCAP_Human0.88774983
122TBL1_22424771_ChIP-Seq_293T_Human0.88407358
123SMAD4_21799915_ChIP-Seq_A2780_Human0.87986286
124RUNX_20019798_ChIP-Seq_JUKART_Human0.87556908
125CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.87538865
126UBF1/2_26484160_Chip-Seq_HMECs_Human0.86989277
127TOP2B_26459242_ChIP-Seq_MCF-7_Human0.86977078
128CBX2_22325352_ChIP-Seq_293T-Rex_Human0.86730810
129NFIB_24661679_ChIP-Seq_LUNG_Mouse0.86278377
130CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85735596
131PPARA_22158963_ChIP-Seq_LIVER_Mouse0.84766454
132NFYB_21822215_ChIP-Seq_K562_Human0.84559750
133RING1B_27294783_Chip-Seq_NPCs_Mouse0.84514768
134EGR1_19374776_ChIP-ChIP_THP-1_Human0.83948582
135JARID2_20075857_ChIP-Seq_MESCs_Mouse0.82050553
136ELF1_20517297_ChIP-Seq_JURKAT_Human0.81249766
137PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.81168245
138* TBX20_22080862_ChIP-Seq_HEART_Mouse0.81032007
139* TBX20_22328084_ChIP-Seq_HEART_Mouse0.81032007
140TCF3_18692474_ChIP-Seq_MEFs_Mouse0.80490161
141CTNNB1_20460455_ChIP-Seq_HCT116_Human0.80284987
142CEBPB_22108803_ChIP-Seq_LS180_Human0.80167745
143NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.80094171
144NRF2_20460467_ChIP-Seq_MEFs_Mouse0.80094171
145SMAD4_21741376_ChIP-Seq_HESCs_Human0.80015866
146THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.79539843

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002132_abnormal_respiratory_system4.75720615
2MP0010030_abnormal_orbit_morphology3.14173016
3MP0010234_abnormal_vibrissa_follicle3.08148415
4MP0008789_abnormal_olfactory_epithelium2.98881332
5MP0005623_abnormal_meninges_morphology2.87595229
6MP0001346_abnormal_lacrimal_gland2.84019222
7MP0004133_heterotaxia2.82539292
8MP0005499_abnormal_olfactory_system2.74717751
9MP0005394_taste/olfaction_phenotype2.74717751
10MP0004264_abnormal_extraembryonic_tissu2.72575580
11MP0005248_abnormal_Harderian_gland2.70475241
12MP0004019_abnormal_vitamin_homeostasis2.57942160
13MP0003011_delayed_dark_adaptation2.30985969
14MP0000566_synostosis2.29726604
15MP0001664_abnormal_digestion2.22709888
16MP0000537_abnormal_urethra_morphology2.14537276
17MP0005503_abnormal_tendon_morphology2.09826280
18MP0002282_abnormal_trachea_morphology2.07370848
19MP0004272_abnormal_basement_membrane2.04574662
20MP0000470_abnormal_stomach_morphology2.03407188
21MP0001666_abnormal_nutrient_absorption2.02371463
22MP0008004_abnormal_stomach_pH11.6432471
23MP0000372_irregular_coat_pigmentation1.92355363
24MP0002168_other_aberrant_phenotype1.81242562
25MP0002254_reproductive_system_inflammat1.79421781
26MP0001984_abnormal_olfaction1.77072553
27MP0000678_abnormal_parathyroid_gland1.74722531
28MP0003941_abnormal_skin_development1.72159436
29MP0005408_hypopigmentation1.68580801
30MP0002098_abnormal_vibrissa_morphology1.63814179
31MP0003136_yellow_coat_color1.61567778
32MP0001958_emphysema1.58948677
33MP0009053_abnormal_anal_canal1.52366777
34MP0009384_cardiac_valve_regurgitation1.51810120
35MP0010678_abnormal_skin_adnexa1.49034338
36MP0001765_abnormal_ion_homeostasis1.44324002
37MP0008875_abnormal_xenobiotic_pharmacok1.42647805
38MP0001873_stomach_inflammation1.38619984
39MP0002233_abnormal_nose_morphology1.36369053
40MP0004782_abnormal_surfactant_physiolog1.35395015
41MP0005083_abnormal_biliary_tract1.34906232
42MP0001485_abnormal_pinna_reflex1.34348261
43MP0000534_abnormal_ureter_morphology1.32592536
44MP0002249_abnormal_larynx_morphology1.23558111
45MP0002876_abnormal_thyroid_physiology1.22885686
46MP0001849_ear_inflammation1.20987304
47MP0000681_abnormal_thyroid_gland1.20879165
48MP0003656_abnormal_erythrocyte_physiolo1.19145723
49MP0001177_atelectasis1.17118821
50MP0005377_hearing/vestibular/ear_phenot1.15193623
51MP0003878_abnormal_ear_physiology1.15193623
52MP0010155_abnormal_intestine_physiology1.13835384
53MP0000762_abnormal_tongue_morphology1.13245756
54MP0003300_gastrointestinal_ulcer1.07068554
55MP0005275_abnormal_skin_tensile1.05824180
56MP0000613_abnormal_salivary_gland1.02534973
57MP0005164_abnormal_response_to1.02437584
58MP0009780_abnormal_chondrocyte_physiolo0.99425544
59MP0003186_abnormal_redox_activity0.99133288
60MP0001879_abnormal_lymphatic_vessel0.96482546
61MP0005085_abnormal_gallbladder_physiolo0.95887104
62MP0002108_abnormal_muscle_morphology0.95831712
63MP0002877_abnormal_melanocyte_morpholog0.94134871
64MP0000462_abnormal_digestive_system0.93263581
65MP0005666_abnormal_adipose_tissue0.93145375
66MP0000467_abnormal_esophagus_morphology0.92835549
67MP0005508_abnormal_skeleton_morphology0.91260791
68MP0009643_abnormal_urine_homeostasis0.90130299
69MP0005636_abnormal_mineral_homeostasis0.89453009
70MP0005395_other_phenotype0.89226931
71MP0003705_abnormal_hypodermis_morpholog0.88281507
72MP0001663_abnormal_digestive_system0.88036408
73MP0003303_peritoneal_inflammation0.87396279
74MP0005023_abnormal_wound_healing0.86553198
75MP0003115_abnormal_respiratory_system0.86512034
76MP0003123_paternal_imprinting0.85806105
77MP0000465_gastrointestinal_hemorrhage0.83766481
78MP0002136_abnormal_kidney_physiology0.83246200
79MP0002277_abnormal_respiratory_mucosa0.81236566
80MP0001324_abnormal_eye_pigmentation0.80963123
81MP0005365_abnormal_bile_salt0.80705858
82MP0000013_abnormal_adipose_tissue0.80663356
83MP0005409_darkened_coat_color0.80549977
84MP0002653_abnormal_ependyma_morphology0.80212778
85MP0004043_abnormal_pH_regulation0.79911878
86MP0002638_abnormal_pupillary_reflex0.79280408
87MP0005381_digestive/alimentary_phenotyp0.77430627
88MP0010329_abnormal_lipoprotein_level0.75822272
89MP0000383_abnormal_hair_follicle0.75570993
90MP0003453_abnormal_keratinocyte_physiol0.75427387
91MP0001790_abnormal_immune_system0.74966217
92MP0005387_immune_system_phenotype0.74966217
93MP0001881_abnormal_mammary_gland0.74577654
94MP0002928_abnormal_bile_duct0.73176495
95MP0002697_abnormal_eye_size0.72974704
96MP0002295_abnormal_pulmonary_circulatio0.72564445
97MP0002405_respiratory_system_inflammati0.72475061
98MP0008995_early_reproductive_senescence0.71473554
99MP0005253_abnormal_eye_physiology0.71291148
100MP0003566_abnormal_cell_adhesion0.70439113
101MP0002160_abnormal_reproductive_system0.70347873
102MP0010352_gastrointestinal_tract_polyps0.70286984
103MP0002896_abnormal_bone_mineralization0.70125085
104MP0005165_increased_susceptibility_to0.69477345
105MP0003942_abnormal_urinary_system0.68512540
106MP0002133_abnormal_respiratory_system0.68338790
107MP0005388_respiratory_system_phenotype0.68338790
108MP0005220_abnormal_exocrine_pancreas0.67610430
109MP0005171_absent_coat_pigmentation0.67493501
110MP0005197_abnormal_uvea_morphology0.67291006
111MP0002234_abnormal_pharynx_morphology0.67182418
112MP0002796_impaired_skin_barrier0.66671522
113MP0009379_abnormal_foot_pigmentation0.65261783
114MP0002909_abnormal_adrenal_gland0.65025012
115MP0003937_abnormal_limbs/digits/tail_de0.63228324
116MP0005375_adipose_tissue_phenotype0.62853302
117MP0001270_distended_abdomen0.62509420
118MP0006054_spinal_hemorrhage0.61813630
119MP0000631_abnormal_neuroendocrine_gland0.61754128
120MP0001502_abnormal_circadian_rhythm0.61241172
121MP0008872_abnormal_physiological_respon0.61017366
122MP0003119_abnormal_digestive_system0.59490869
123MP0000026_abnormal_inner_ear0.58896545
124MP0000049_abnormal_middle_ear0.58440502
125MP0003938_abnormal_ear_development0.58278813
126MP0003045_fibrosis0.56891505
127MP0000477_abnormal_intestine_morphology0.56837919
128MP0009703_decreased_birth_body0.56481732
129MP0003879_abnormal_hair_cell0.55693049
130MP0003950_abnormal_plasma_membrane0.54954669
131MP0000377_abnormal_hair_follicle0.53536934
132MP0009765_abnormal_xenobiotic_induced0.53329251
133MP0001286_abnormal_eye_development0.52779934
134MP0010368_abnormal_lymphatic_system0.52278172
135MP0001963_abnormal_hearing_physiology0.50828729
136MP0003091_abnormal_cell_migration0.49700064
137MP0004883_abnormal_blood_vessel0.49108644
138MP0001299_abnormal_eye_distance/0.48830146
139MP0000627_abnormal_mammary_gland0.48511573
140MP0003279_aneurysm0.48470318
141MP0000432_abnormal_head_morphology0.48219485
142MP0003786_premature_aging0.48057733
143MP0000490_abnormal_crypts_of0.47719809
144MP0002092_abnormal_eye_morphology0.47360889
145MP0010386_abnormal_urinary_bladder0.47351550
146MP0002938_white_spotting0.46831932
147MP0003943_abnormal_hepatobiliary_system0.46738521
148MP0008961_abnormal_basal_metabolism0.46624288
149MP0005551_abnormal_eye_electrophysiolog0.45995142
150MP0002116_abnormal_craniofacial_bone0.45721034
151MP0005645_abnormal_hypothalamus_physiol0.45523995
152MP0002139_abnormal_hepatobiliary_system0.45290433
153MP0003755_abnormal_palate_morphology0.45175290

Predicted human phenotypes

RankGene SetZ-score
1Rhinitis (HP:0012384)9.84368993
2Ventricular fibrillation (HP:0001663)8.74175512
3Bronchiectasis (HP:0002110)7.35909440
4Nasal polyposis (HP:0100582)6.67729175
5Vascular calcification (HP:0004934)5.76022104
6Abnormality of the nasal mucosa (HP:0000433)5.67082887
7Cardiovascular calcification (HP:0011915)5.23917607
8Prolonged QT interval (HP:0001657)4.99865181
9Arterial tortuosity (HP:0005116)4.94615237
10Syncope (HP:0001279)4.77390658
11Bronchitis (HP:0012387)4.50856437
12Recurrent sinusitis (HP:0011108)4.46999593
13Vascular tortuosity (HP:0004948)4.41691865
14Chronic sinusitis (HP:0011109)4.24019761
15Right ventricular cardiomyopathy (HP:0011663)4.13910471
16Infertility (HP:0000789)4.11115041
17Recurrent otitis media (HP:0000403)3.79460378
18Abnormality of vitamin B metabolism (HP:0004340)3.76488693
19Male infertility (HP:0003251)3.74582098
20Chronic otitis media (HP:0000389)3.51405924
21Occipital encephalocele (HP:0002085)3.50434190
22Stomach cancer (HP:0012126)3.45117380
23Increased CSF protein (HP:0002922)3.34984941
24Micronodular cirrhosis (HP:0001413)3.32306942
25Abnormality of vitamin metabolism (HP:0100508)3.30874656
26Onycholysis (HP:0001806)3.30189826
27Epiphyseal dysplasia (HP:0002656)3.16943999
28Pancreatic fibrosis (HP:0100732)3.11921176
29True hermaphroditism (HP:0010459)3.11129203
30Ventricular arrhythmia (HP:0004308)3.10311255
31Milia (HP:0001056)3.01736654
32Urethral obstruction (HP:0000796)3.00992645
33Atelectasis (HP:0100750)2.97487047
34Abnormal EKG (HP:0003115)2.93057359
35Absent eyelashes (HP:0000561)2.86344680
36Choroideremia (HP:0001139)2.81569453
37Cystic liver disease (HP:0006706)2.77676755
38Annular pancreas (HP:0001734)2.75003354
39Abnormality of the distal phalanges of the toes (HP:0010182)2.70252878
40Hyperphosphatemia (HP:0002905)2.65667244
41Abnormality of the nasal septum (HP:0000419)2.64871347
42Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.60356641
43Abnormal pancreas size (HP:0012094)2.60313247
44Abnormality of midbrain morphology (HP:0002418)2.58845823
45Molar tooth sign on MRI (HP:0002419)2.58845823
46Pancreatic cysts (HP:0001737)2.58370677
47Nephronophthisis (HP:0000090)2.56507350
48Growth hormone excess (HP:0000845)2.53017838
49Median cleft lip (HP:0000161)2.48001984
50Absent eyebrow (HP:0002223)2.47244909
51Hypoplasia of dental enamel (HP:0006297)2.46761710
52Abnormality of the dental root (HP:0006486)2.43560788
53Taurodontia (HP:0000679)2.43560788
54Abnormality of permanent molar morphology (HP:0011071)2.43560788
55Hypothermia (HP:0002045)2.43072005
56Lip pit (HP:0100267)2.40723742
57Orthostatic hypotension (HP:0001278)2.37698388
58Chronic hepatic failure (HP:0100626)2.37298026
59Abnormality of the dental pulp (HP:0006479)2.30208214
60Atrophic scars (HP:0001075)2.29629194
61Rectal prolapse (HP:0002035)2.28915164
62Aplasia involving bones of the extremities (HP:0009825)2.28531981
63Aplasia involving bones of the upper limbs (HP:0009823)2.28531981
64Aplasia of the phalanges of the hand (HP:0009802)2.28531981
65Renal salt wasting (HP:0000127)2.27899290
66Abnormality of the vitamin B12 metabolism (HP:0004341)2.27094128
67Bell-shaped thorax (HP:0001591)2.23940223
68Abnormality of molar (HP:0011077)2.21968882
69Abnormality of molar morphology (HP:0011070)2.21968882
70Recurrent bronchitis (HP:0002837)2.20202734
71Abnormality of the fovea (HP:0000493)2.19214655
72Tubulointerstitial fibrosis (HP:0005576)2.18064253
73Atrial fibrillation (HP:0005110)2.17733431
74Interstitial pulmonary disease (HP:0006530)2.16741123
75Split foot (HP:0001839)2.16413828
76Abnormality of the renal medulla (HP:0100957)2.15275254
77Synostosis involving bones of the feet (HP:0009140)2.13144694
78Synostosis involving bones of the lower limbs (HP:0009138)2.13144694
79Postaxial foot polydactyly (HP:0001830)2.12086528
80Hypotension (HP:0002615)2.10961158
81Hyperactive renin-angiotensin system (HP:0000841)2.10546261
82Subcapsular cataract (HP:0000523)2.09994825
83Preauricular pit (HP:0004467)2.08814462
84Periauricular skin pits (HP:0100277)2.08814462
85Subacute progressive viral hepatitis (HP:0006572)2.08557080
86Morphological abnormality of the middle ear (HP:0008609)2.08456153
87Tubular atrophy (HP:0000092)2.08133907
88Flat acetabular roof (HP:0003180)2.06981995
89Tarsal synostosis (HP:0008368)2.05896085
90Decreased circulating renin level (HP:0003351)2.04986292
91Primary atrial arrhythmia (HP:0001692)2.03536130
92Severe Myopia (HP:0011003)2.03111007
93Bicuspid aortic valve (HP:0001647)2.01085922
94Bronchomalacia (HP:0002780)2.00592942
95Respiratory insufficiency due to defective ciliary clearance (HP:0200073)11.9336928
96Abnormal respiratory epithelium morphology (HP:0012253)10.8293819
97Abnormal respiratory motile cilium morphology (HP:0005938)10.8293819
98Abnormal respiratory motile cilium physiology (HP:0012261)10.7306000
99Abnormal ciliary motility (HP:0012262)10.5772059
100Dynein arm defect of respiratory motile cilia (HP:0012255)10.4149729
101Absent/shortened dynein arms (HP:0200106)10.4149729
102Bilateral microphthalmos (HP:0007633)1.99964705
103Abnormality of the gastric mucosa (HP:0004295)1.99066625
104Abnormality of the middle phalanges of the toes (HP:0010183)1.99016288
105Abnormal number of erythroid precursors (HP:0012131)1.97488333
106Sudden cardiac death (HP:0001645)1.97362886
107Hyperkalemia (HP:0002153)1.95241570
108Tubulointerstitial nephritis (HP:0001970)1.95197573
109Fragile nails (HP:0001808)1.94098330
110Absent frontal sinuses (HP:0002688)1.93645239
111Supraventricular arrhythmia (HP:0005115)1.92551481
112Anterior segment dysgenesis (HP:0007700)1.92305195
113Supraventricular tachycardia (HP:0004755)1.91371276
114Congenital hepatic fibrosis (HP:0002612)1.91312083
115Cerebral aneurysm (HP:0004944)1.90702042
116Woolly hair (HP:0002224)1.90569928
117Aplasia/Hypoplasia of the tongue (HP:0010295)1.89398744
118Facial cleft (HP:0002006)1.89265373
119Aortic dissection (HP:0002647)1.88694580
120Aortic aneurysm (HP:0004942)1.87128180
121Chronic bronchitis (HP:0004469)1.86352219
122Renal tubular acidosis (HP:0001947)1.81963393
123Abnormality of renal excretion (HP:0011036)1.81049849
124Abnormality of the vitreous humor (HP:0004327)1.80657969
125Abnormality of chloride homeostasis (HP:0011422)1.79904302
126Plantar hyperkeratosis (HP:0007556)1.79641101
127Asymmetry of the thorax (HP:0001555)1.76561167
128Turricephaly (HP:0000262)1.75984466
129Abnormal biliary tract morphology (HP:0012440)1.75527214
130Medial flaring of the eyebrow (HP:0010747)1.74910972
131Oligodontia (HP:0000677)1.74463522
132Gastrointestinal atresia (HP:0002589)1.73567337
133Anencephaly (HP:0002323)1.73256837
134Esophageal atresia (HP:0002032)1.72949761
135Abnormality of renal resorption (HP:0011038)1.72500668
136Abnormality of cells of the erythroid lineage (HP:0012130)1.71411915
137Neonatal short-limb short stature (HP:0008921)1.71288449
138Bifid scrotum (HP:0000048)1.70523657
139Male pseudohermaphroditism (HP:0000037)1.69869788
140Hyperaldosteronism (HP:0000859)1.69826148
141Down-sloping shoulders (HP:0200021)1.69233294
142Abnormality of the phalanges of the 2nd finger (HP:0009541)1.66997567
143Tubulointerstitial abnormality (HP:0001969)1.66506151
144Progressive sensorineural hearing impairment (HP:0000408)1.66253268
145Abnormality of the aortic arch (HP:0012303)1.65907678
146Nephropathy (HP:0000112)1.64801820
147Short nail (HP:0001799)1.62556882
148Furrowed tongue (HP:0000221)1.61757515
149Congenital primary aphakia (HP:0007707)1.59398569
150Abnormality of renin-angiotensin system (HP:0000847)1.58895977
151Gait imbalance (HP:0002141)1.58445275
152Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.49681597
153Aplasia/Hypoplasia of the spleen (HP:0010451)1.49007213
154Stage 5 chronic kidney disease (HP:0003774)1.48252469
155Asplenia (HP:0001746)1.46512348
156Hypokalemic alkalosis (HP:0001949)1.43837341
157Postaxial hand polydactyly (HP:0001162)1.42068661
158Glucose intolerance (HP:0000833)1.41856827
159Cone-rod dystrophy (HP:0000548)1.40309710
160Oculomotor apraxia (HP:0000657)1.40262671
161Sclerocornea (HP:0000647)1.39770272
162Abnormality of dentin (HP:0010299)1.38329282
163Nephrogenic diabetes insipidus (HP:0009806)1.35452345
164Decreased central vision (HP:0007663)1.31050781
165Vaginal atresia (HP:0000148)1.23883012
166Short thorax (HP:0010306)1.22545697
167Genital tract atresia (HP:0001827)1.22271755
168Hyponatremia (HP:0002902)1.21903524
169Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.18652493
170Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.18176556
171Abnormality of macular pigmentation (HP:0008002)1.17127523
172Distal lower limb muscle weakness (HP:0009053)1.16275754
173Preaxial hand polydactyly (HP:0001177)1.15933439
174Abnormality of the frontal sinuses (HP:0002687)1.15862524
175Broad distal phalanx of finger (HP:0009836)1.09626296
176Popliteal pterygium (HP:0009756)1.08221172
177Poor coordination (HP:0002370)1.06411046
178Abnormality of monocarboxylic acid metabolism (HP:0010996)1.04063436
179Nonprogressive disorder (HP:0003680)1.03286152
180Obstructive sleep apnea (HP:0002870)1.02162621
181Abnormality of the renal cortex (HP:0011035)1.01483042
182Aplasia of the musculature (HP:0100854)0.98606034

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST45.20872441
2STK393.96192018
3MAPKAPK33.55509147
4LMTK23.23053941
5MAP3K23.22227134
6RIPK13.19038514
7MAP3K32.83211125
8WNK42.82407072
9STK242.53455314
10MAP2K22.41440647
11EPHA22.26555148
12TGFBR22.22780367
13TESK12.04353204
14SMG12.02978652
15PTK61.85214302
16MATK1.85163727
17LRRK21.78503494
18STK101.76672445
19GRK11.74158460
20PAK31.73635793
21MAPK151.72072330
22SIK11.69872756
23PKN21.67136878
24ERBB31.65091327
25PAK41.61904723
26DDR21.59500386
27MST1R1.57828649
28FER1.49479949
29RPS6KB21.48465209
30EPHB11.48312207
31MUSK1.44221258
32LATS11.43405729
33TESK21.38178755
34PTK2B1.36828157
35MAP3K71.34072898
36FRK1.32934817
37TRPM71.25504292
38WNK11.22306483
39CAMKK11.20375905
40EPHB21.19993454
41MAP2K11.17667497
42CSK1.16803178
43FGFR21.15422585
44ERBB21.13301704
45BCR1.12427803
46EEF2K1.08969640
47PTK21.01894571
48TBK11.00578086
49RPS6KA21.00175752
50HIPK20.99647941
51CDK60.99163549
52TRIB30.95766668
53TTK0.95002643
54PRKG20.88581877
55ILK0.87967753
56RIPK40.87811795
57NLK0.86518709
58MARK20.85712749
59PNCK0.85401081
60PIK3CA0.79613145
61DAPK20.78241556
62CAMK40.77929985
63STK30.76133456
64NEK60.73353019
65AKT20.73311654
66FGFR30.71387978
67LIMK10.70915068
68MAP3K120.70709638
69OXSR10.70232791
70ICK0.69886493
71CDC42BPA0.69763345
72TAOK10.67326627
73MET0.66314002
74EPHA30.64773887
75TLK10.64542469
76PDGFRB0.63984409
77NUAK10.63631881
78ZAP700.62180341
79MYLK0.60728793
80SGK20.58452830
81FGFR40.57708177
82DMPK0.57421409
83NME10.56966038
84RPS6KC10.56231701
85RPS6KL10.56231701
86BMX0.55388975
87CAMK10.54830823
88PDPK10.52316659
89SGK30.50486096
90PRKCQ0.49966784
91PDK20.48432893
92PRKCD0.48191420
93ROCK10.47659398
94TYK20.47384087
95MAP3K90.46414448
96CHUK0.46103187
97CAMKK20.45524323
98PRKCI0.44730692
99FGFR10.44057740
100MAP3K110.44014025
101RPS6KA60.42924500
102PASK0.42878572
103MAP3K80.41453844
104NEK10.41278898
105MAP3K100.40945274
106RET0.40696928
107ERN10.40365692
108IRAK10.39624625
109ALK0.37852583
110CAMK2D0.37488236
111SGK2230.36847114
112SGK4940.36847114
113ROCK20.36689876
114STK38L0.36355832
115PRKAA20.36226342
116JAK20.34332009
117NEK90.34054276
118STK160.33183301
119BRSK20.32096400
120PAK20.31945436
121MAP3K40.31722123
122STK380.31470677
123MELK0.30820158
124CAMK1D0.30275672
125PRKCZ0.30118461
126PRKCE0.29343094
127PDK10.28981646
128ERBB40.27938591
129ABL10.27752560
130PRKD10.27382543
131SGK10.26826004
132MAP3K10.26345305
133GSK3A0.25935494
134BMPR20.25458699
135KSR20.25416289
136MAP3K60.25381560
137MAPKAPK50.25128913
138INSRR0.22961109
139CAMK2G0.22218409
140CCNB10.21377906
141EGFR0.19145489
142PRKD20.19045187
143SRC0.17959912
144JAK10.16936694
145DYRK1B0.16851534
146IGF1R0.16345324
147PRKCH0.16182824
148MAPK70.15957122
149PRKACA0.15647862

Predicted pathways (KEGG)

RankGene SetZ-score
1Drug metabolism - cytochrome P450_Homo sapiens_hsa009824.00136421
2Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009803.59506164
3Pentose and glucuronate interconversions_Homo sapiens_hsa000403.48885550
4Gastric acid secretion_Homo sapiens_hsa049713.24878546
5Chemical carcinogenesis_Homo sapiens_hsa052042.71008489
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.59296001
7Sulfur metabolism_Homo sapiens_hsa009202.43225299
8Glutathione metabolism_Homo sapiens_hsa004802.40948774
9Protein digestion and absorption_Homo sapiens_hsa049742.22902160
10Huntingtons disease_Homo sapiens_hsa050162.17872242
11Fat digestion and absorption_Homo sapiens_hsa049752.04274475
12Collecting duct acid secretion_Homo sapiens_hsa049662.01253861
13Pancreatic secretion_Homo sapiens_hsa049721.95308552
14Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.78236247
15Starch and sucrose metabolism_Homo sapiens_hsa005001.73355667
16Tight junction_Homo sapiens_hsa045301.70962300
17Retinol metabolism_Homo sapiens_hsa008301.66403280
18Vitamin digestion and absorption_Homo sapiens_hsa049771.62700625
19Adherens junction_Homo sapiens_hsa045201.61835895
20Mineral absorption_Homo sapiens_hsa049781.61537185
21Sphingolipid metabolism_Homo sapiens_hsa006001.52985313
22Histidine metabolism_Homo sapiens_hsa003401.50710357
23Nitrogen metabolism_Homo sapiens_hsa009101.46027019
24Hippo signaling pathway_Homo sapiens_hsa043901.45021623
25Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.35317852
26ABC transporters_Homo sapiens_hsa020101.35114305
27Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.29248796
28beta-Alanine metabolism_Homo sapiens_hsa004101.24243499
29Leukocyte transendothelial migration_Homo sapiens_hsa046701.14864178
30Circadian rhythm_Homo sapiens_hsa047101.13600616
31Intestinal immune network for IgA production_Homo sapiens_hsa046721.10855240
32Thyroid hormone synthesis_Homo sapiens_hsa049181.10765542
33Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.08230173
34TGF-beta signaling pathway_Homo sapiens_hsa043501.07100192
35Allograft rejection_Homo sapiens_hsa053301.06821691
36Endometrial cancer_Homo sapiens_hsa052131.06134702
37Asthma_Homo sapiens_hsa053101.05890796
38Complement and coagulation cascades_Homo sapiens_hsa046101.04610290
39Olfactory transduction_Homo sapiens_hsa047401.03743840
40Colorectal cancer_Homo sapiens_hsa052101.03540955
41Autoimmune thyroid disease_Homo sapiens_hsa053201.01954098
42ECM-receptor interaction_Homo sapiens_hsa045121.01554135
43Propanoate metabolism_Homo sapiens_hsa006401.01332495
44Vibrio cholerae infection_Homo sapiens_hsa051101.00340783
45Galactose metabolism_Homo sapiens_hsa000520.94973788
46Carbohydrate digestion and absorption_Homo sapiens_hsa049730.94933808
47Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.94930640
48Fatty acid degradation_Homo sapiens_hsa000710.94752183
49Glycerolipid metabolism_Homo sapiens_hsa005610.92665657
50Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.92136263
51Arachidonic acid metabolism_Homo sapiens_hsa005900.89906143
52Bile secretion_Homo sapiens_hsa049760.86433391
53Salivary secretion_Homo sapiens_hsa049700.85980770
54Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.85342888
55Type I diabetes mellitus_Homo sapiens_hsa049400.84030714
56Proteoglycans in cancer_Homo sapiens_hsa052050.83519759
57Graft-versus-host disease_Homo sapiens_hsa053320.82047928
58Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.81220065
59Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.79266026
60Phenylalanine metabolism_Homo sapiens_hsa003600.78971561
61Staphylococcus aureus infection_Homo sapiens_hsa051500.78594276
62Focal adhesion_Homo sapiens_hsa045100.78465908
63Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.77685569
64Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.77062234
65Chronic myeloid leukemia_Homo sapiens_hsa052200.76427226
66Basal cell carcinoma_Homo sapiens_hsa052170.73517931
67Ether lipid metabolism_Homo sapiens_hsa005650.72665146
68Pancreatic cancer_Homo sapiens_hsa052120.72468315
69Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.72141047
70Prostate cancer_Homo sapiens_hsa052150.71245154
71Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.70146192
72Estrogen signaling pathway_Homo sapiens_hsa049150.70061608
73AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.69083287
74Bladder cancer_Homo sapiens_hsa052190.68854905
75Peroxisome_Homo sapiens_hsa041460.67646589
76Thyroid cancer_Homo sapiens_hsa052160.66674806
77Notch signaling pathway_Homo sapiens_hsa043300.65631634
78Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.63607139
79Renal cell carcinoma_Homo sapiens_hsa052110.63319750
80Tyrosine metabolism_Homo sapiens_hsa003500.62806647
81Choline metabolism in cancer_Homo sapiens_hsa052310.62673223
82Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.60726270
83Caffeine metabolism_Homo sapiens_hsa002320.59779848
84Cyanoamino acid metabolism_Homo sapiens_hsa004600.57555459
85Phototransduction_Homo sapiens_hsa047440.56782685
86Lysosome_Homo sapiens_hsa041420.55420897
87Prolactin signaling pathway_Homo sapiens_hsa049170.55180720
88Glycerophospholipid metabolism_Homo sapiens_hsa005640.54219848
89Primary bile acid biosynthesis_Homo sapiens_hsa001200.53433738
90Wnt signaling pathway_Homo sapiens_hsa043100.52672077
91Hedgehog signaling pathway_Homo sapiens_hsa043400.51491976
92Melanogenesis_Homo sapiens_hsa049160.51132253
93Hepatitis C_Homo sapiens_hsa051600.48518583
94alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.45999870
95Small cell lung cancer_Homo sapiens_hsa052220.45204197
96Non-small cell lung cancer_Homo sapiens_hsa052230.44447332
97Antigen processing and presentation_Homo sapiens_hsa046120.44063936
98Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.43871464
99PPAR signaling pathway_Homo sapiens_hsa033200.43459951
100Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.42719544
101Taste transduction_Homo sapiens_hsa047420.42715526
102mTOR signaling pathway_Homo sapiens_hsa041500.42099459
103Hematopoietic cell lineage_Homo sapiens_hsa046400.41537878
104Rheumatoid arthritis_Homo sapiens_hsa053230.41482556
105Cholinergic synapse_Homo sapiens_hsa047250.41137860
106Amphetamine addiction_Homo sapiens_hsa050310.40589374
107Phagosome_Homo sapiens_hsa041450.39738421
108Insulin resistance_Homo sapiens_hsa049310.39450867
109ErbB signaling pathway_Homo sapiens_hsa040120.38924396
110Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.38650497
111Transcriptional misregulation in cancer_Homo sapiens_hsa052020.38303266
112Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.36659202
113Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.36189275
114Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.35654555
115Toxoplasmosis_Homo sapiens_hsa051450.35568482
116Amoebiasis_Homo sapiens_hsa051460.34974829
117Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.34244673
118Linoleic acid metabolism_Homo sapiens_hsa005910.33915298
119Dilated cardiomyopathy_Homo sapiens_hsa054140.33549998
120Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.33085361
121Glycosaminoglycan degradation_Homo sapiens_hsa005310.32992712
122Cocaine addiction_Homo sapiens_hsa050300.32685108
123GnRH signaling pathway_Homo sapiens_hsa049120.31460581
124Steroid hormone biosynthesis_Homo sapiens_hsa001400.30352491
125Pathways in cancer_Homo sapiens_hsa052000.29678169
126Gap junction_Homo sapiens_hsa045400.29448775
127Central carbon metabolism in cancer_Homo sapiens_hsa052300.29440674
128Tryptophan metabolism_Homo sapiens_hsa003800.29340814
129Longevity regulating pathway - mammal_Homo sapiens_hsa042110.28341944
130Rap1 signaling pathway_Homo sapiens_hsa040150.28230714
131Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.28104605
132Drug metabolism - other enzymes_Homo sapiens_hsa009830.27279856
133Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.27041372
134Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.26865829
135Jak-STAT signaling pathway_Homo sapiens_hsa046300.26189377
136Glioma_Homo sapiens_hsa052140.26088865
137Sulfur relay system_Homo sapiens_hsa041220.25897017
138Viral myocarditis_Homo sapiens_hsa054160.25459604
139Influenza A_Homo sapiens_hsa051640.25442808
140cAMP signaling pathway_Homo sapiens_hsa040240.25360022
141Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.23329365
142Ovarian steroidogenesis_Homo sapiens_hsa049130.21682027
143Pertussis_Homo sapiens_hsa051330.18858722
144TNF signaling pathway_Homo sapiens_hsa046680.14824942
145Axon guidance_Homo sapiens_hsa043600.14471619

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