CLINT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein with similarity to the epsin family of endocytic adapter proteins. The encoded protein interacts with clathrin, the adapter protein AP-1 and phosphoinositides. This protein may be involved in the formation of clathrin coated vesicles and trafficking between the trans-Golgi network and endosomes. Mutations in this gene are associated with a susceptibility to schizophrenia and psychotic disorders. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.80978797
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.80978797
3antigen processing and presentation of endogenous antigen (GO:0019883)4.13597348
4desmosome organization (GO:0002934)4.02608810
5positive regulation of gamma-delta T cell activation (GO:0046645)3.93576900
6regulation of gamma-delta T cell differentiation (GO:0045586)3.69584419
7positive regulation of histone deacetylation (GO:0031065)3.58421383
8COPI coating of Golgi vesicle (GO:0048205)3.57502321
9Golgi transport vesicle coating (GO:0048200)3.57502321
10hepatocyte apoptotic process (GO:0097284)3.52595428
11regulation of gamma-delta T cell activation (GO:0046643)3.28125850
12antigen processing and presentation via MHC class Ib (GO:0002475)3.24253359
13ribosome assembly (GO:0042255)3.11022597
14definitive hemopoiesis (GO:0060216)3.08805217
15antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.03833716
16dosage compensation (GO:0007549)3.02669130
17Arp2/3 complex-mediated actin nucleation (GO:0034314)2.98561439
18bundle of His cell to Purkinje myocyte communication (GO:0086069)2.96672678
19positive regulation of B cell differentiation (GO:0045579)2.91968939
20regulation of water loss via skin (GO:0033561)2.91181826
21glucocorticoid receptor signaling pathway (GO:0042921)2.90361281
22ER overload response (GO:0006983)2.88858847
23positive thymic T cell selection (GO:0045059)2.87270958
24establishment of skin barrier (GO:0061436)2.86829248
25JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.84683814
26tolerance induction (GO:0002507)2.78198130
27negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.76281748
28negative regulation of erythrocyte differentiation (GO:0045647)2.75956446
29diterpenoid biosynthetic process (GO:0016102)2.75779675
30activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.74681035
31regulation of interleukin-12 biosynthetic process (GO:0045075)2.73392857
32positive regulation of nuclease activity (GO:0032075)2.72754111
33positive regulation of protein deacetylation (GO:0090312)2.70735046
34germ cell migration (GO:0008354)2.68681308
353-UTR-mediated mRNA stabilization (GO:0070935)2.67967268
36regulation of RNA export from nucleus (GO:0046831)2.63334029
37negative regulation of phagocytosis (GO:0050765)2.61896806
38corticosteroid receptor signaling pathway (GO:0031958)2.61369789
39natural killer cell differentiation (GO:0001779)2.59294712
40formation of translation preinitiation complex (GO:0001731)2.58674400
41embryonic process involved in female pregnancy (GO:0060136)2.57773238
42histone H2B ubiquitination (GO:0033523)2.54340072
43regulation of nuclease activity (GO:0032069)2.53837858
44hepatocyte differentiation (GO:0070365)2.53629700
45positive regulation of histone H3-K4 methylation (GO:0051571)2.52731816
46growth hormone receptor signaling pathway (GO:0060396)2.51529305
47leukocyte aggregation (GO:0070486)2.51252547
48T cell apoptotic process (GO:0070231)2.50731749
49nuclear pore complex assembly (GO:0051292)2.50384057
50hypotonic response (GO:0006971)2.50136751
51poly(A)+ mRNA export from nucleus (GO:0016973)2.50120373
52endoplasmic reticulum unfolded protein response (GO:0030968)2.49581177
53RNA stabilization (GO:0043489)2.46959000
54mRNA stabilization (GO:0048255)2.46959000
55megakaryocyte development (GO:0035855)2.43000755
56pinocytosis (GO:0006907)2.42169290
57multicellular organismal water homeostasis (GO:0050891)2.41500259
58folic acid-containing compound biosynthetic process (GO:0009396)2.40899598
59positive regulation of protein import into nucleus, translocation (GO:0033160)2.39105142
60regulation of translational termination (GO:0006449)2.37490177
61cellular response to unfolded protein (GO:0034620)2.37085736
62cytoplasmic mRNA processing body assembly (GO:0033962)2.35556974
63positive regulation of natural killer cell differentiation (GO:0032825)2.34400872
64embryonic hemopoiesis (GO:0035162)2.34103682
65NIK/NF-kappaB signaling (GO:0038061)2.33871701
66nucleotide-sugar biosynthetic process (GO:0009226)2.33113548
67actin nucleation (GO:0045010)2.32675601
68regulation of histone H3-K27 methylation (GO:0061085)2.32086048
69UDP-N-acetylglucosamine metabolic process (GO:0006047)2.31975626
70mitotic sister chromatid cohesion (GO:0007064)2.30659336
71alternative mRNA splicing, via spliceosome (GO:0000380)2.30469540
72regulation of B cell differentiation (GO:0045577)2.30150144
73regulation of erythrocyte differentiation (GO:0045646)2.30040918
74nuclear pore organization (GO:0006999)2.29166049
75DNA duplex unwinding (GO:0032508)2.28184737
76regulation of translational fidelity (GO:0006450)2.28109414
77regulation of nucleobase-containing compound transport (GO:0032239)2.27718809
78response to laminar fluid shear stress (GO:0034616)2.27713551
79negative regulation of fatty acid transport (GO:2000192)2.27123783
80lymphocyte apoptotic process (GO:0070227)2.27042963
81negative regulation of cell killing (GO:0031342)2.27024158
82negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.27024158
83nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.26459543
84protein localization to chromosome, centromeric region (GO:0071459)2.26287488
85epithelial cell differentiation involved in prostate gland development (GO:0060742)2.26257048
86negative thymic T cell selection (GO:0045060)2.26032895
87maternal placenta development (GO:0001893)2.25824630
88positive regulation of lamellipodium assembly (GO:0010592)2.25794595
89ER-nucleus signaling pathway (GO:0006984)2.25319409
90maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.24892869
91positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.24556521
92leukocyte cell-cell adhesion (GO:0007159)2.24472731
93trophectodermal cell differentiation (GO:0001829)2.24452072
94mitotic chromosome condensation (GO:0007076)2.23292012
95localization within membrane (GO:0051668)2.21653536
96mitotic nuclear envelope disassembly (GO:0007077)2.19366165
97pentose-phosphate shunt (GO:0006098)2.19294007
98negative T cell selection (GO:0043383)2.18900443
99establishment of endothelial barrier (GO:0061028)2.18760691
100regulation of keratinocyte differentiation (GO:0045616)2.18486587
101thymic T cell selection (GO:0045061)2.18469480
102COPII vesicle coating (GO:0048208)2.18020007
103mitotic metaphase plate congression (GO:0007080)2.17421418
104regulation of necroptotic process (GO:0060544)2.17161791
105gap junction assembly (GO:0016264)2.16851449
106ether lipid metabolic process (GO:0046485)2.16590086
107* vesicle coating (GO:0006901)2.16408922
108DNA geometric change (GO:0032392)2.16319403
109regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.15904094
110DNA unwinding involved in DNA replication (GO:0006268)2.15579713
111regulation of transforming growth factor beta1 production (GO:0032908)2.15299522
112negative regulation of DNA repair (GO:0045738)2.14845082
113positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.14517575
114positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.14517575
115positive regulation of mitotic sister chromatid separation (GO:1901970)2.14517575
116cellular response to topologically incorrect protein (GO:0035967)2.14360293
117positive regulation of erythrocyte differentiation (GO:0045648)2.14126132
118regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.13913442
119regulation of interferon-beta biosynthetic process (GO:0045357)2.13698463
120negative regulation of B cell proliferation (GO:0030889)2.13094275
121protein localization to kinetochore (GO:0034501)2.12684571
122valine metabolic process (GO:0006573)2.12351256
123regulation of sister chromatid cohesion (GO:0007063)2.11912975
124regulation of histone H3-K9 methylation (GO:0051570)2.11841697
125cellular response to growth hormone stimulus (GO:0071378)2.11502825
126primary alcohol catabolic process (GO:0034310)2.11266338
127negative regulation of bone resorption (GO:0045779)2.10755940
128regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.08394379
129pyrimidine-containing compound transmembrane transport (GO:0072531)2.08348298
130defense response to fungus (GO:0050832)2.07559627
131sequestering of metal ion (GO:0051238)2.06939501
132ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.06574279
133NLS-bearing protein import into nucleus (GO:0006607)2.06186455
134skin morphogenesis (GO:0043589)2.06111161
135angiogenesis involved in wound healing (GO:0060055)2.04484739
136membrane disassembly (GO:0030397)2.04079425
137nuclear envelope disassembly (GO:0051081)2.04079425
138erythrocyte maturation (GO:0043249)2.03066499
139pore complex assembly (GO:0046931)2.03050154
140proline biosynthetic process (GO:0006561)2.02789402
141DNA topological change (GO:0006265)2.02713155
142regulation of type I interferon-mediated signaling pathway (GO:0060338)2.01486313
143microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.00383650
144positive regulation of SMAD protein import into nucleus (GO:0060391)2.00381897
145cellular extravasation (GO:0045123)1.99067286
146Peyers patch development (GO:0048541)1.98662689
147mucosal-associated lymphoid tissue development (GO:0048537)1.98662689
148necroptotic process (GO:0070266)1.98503337
149regulation of B cell receptor signaling pathway (GO:0050855)1.98259233
150purine ribonucleotide transport (GO:0015868)1.98216915
151positive regulation of granulocyte differentiation (GO:0030854)1.97737171
152morphogenesis of an endothelium (GO:0003159)1.97690980
153keratinocyte differentiation (GO:0030216)1.97138076
154cellular response to ethanol (GO:0071361)1.97096319
155cellular hyperosmotic response (GO:0071474)1.96604662
156establishment of chromosome localization (GO:0051303)1.95585244
157membrane raft organization (GO:0031579)1.95168115
158regulation of metalloenzyme activity (GO:0048552)1.95140670
159regulation of histone H3-K4 methylation (GO:0051569)1.95013083
160regulation of vitamin metabolic process (GO:0030656)1.94575241
161regulation of fibroblast apoptotic process (GO:2000269)1.93217865
162response to hydroperoxide (GO:0033194)1.92840351
163iron ion import (GO:0097286)1.92736368
164rRNA catabolic process (GO:0016075)1.92542250
165vitamin transmembrane transport (GO:0035461)1.92536456
166negative regulation of mRNA splicing, via spliceosome (GO:0048025)1.89705135
167peptidyl-asparagine modification (GO:0018196)1.88762687
168retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)1.88225086
169protein N-linked glycosylation via asparagine (GO:0018279)1.88104672
170intestinal epithelial cell development (GO:0060576)1.87624426

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.58835131
2EGR1_19374776_ChIP-ChIP_THP-1_Human4.27018410
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.55942640
4MYC_22102868_ChIP-Seq_BL_Human3.20497782
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.17068849
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.06428117
7SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.54275082
8IRF8_22096565_ChIP-ChIP_GC-B_Human2.48674025
9STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.44523352
10FOXM1_23109430_ChIP-Seq_U2OS_Human2.40461493
11* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.36422974
12VDR_21846776_ChIP-Seq_THP-1_Human2.28089139
13MYB_21317192_ChIP-Seq_ERMYB_Mouse2.26728798
14SCL_19346495_ChIP-Seq_HPC-7_Human2.24251662
15TP63_17297297_ChIP-ChIP_HaCaT_Human2.23486631
16TCF7_22412390_ChIP-Seq_EML_Mouse2.13015671
17GATA1_22025678_ChIP-Seq_K562_Human2.11356821
18NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.09564428
19MAF_26560356_Chip-Seq_TH1_Human1.95846812
20* MYB_26560356_Chip-Seq_TH2_Human1.94889770
21ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.93590375
22* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.93466365
23ELF1_17652178_ChIP-ChIP_JURKAT_Human1.91352740
24* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.90515558
25MYC_18555785_ChIP-Seq_MESCs_Mouse1.84679487
26STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.84674913
27* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.84209477
28* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.80092467
29UTX_26944678_Chip-Seq_JUKART_Human1.78830679
30PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.78725386
31FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.76458957
32* MYB_26560356_Chip-Seq_TH1_Human1.75582426
33CLOCK_20551151_ChIP-Seq_293T_Human1.74772639
34VDR_24763502_ChIP-Seq_THP-1_Human1.74221236
35KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.72764207
36KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.68019420
37KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.66842189
38TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.61221220
39ELK3_25401928_ChIP-Seq_HUVEC_Human1.60412646
40* RUNX1_22412390_ChIP-Seq_EML_Mouse1.60151999
41RUNX_20019798_ChIP-Seq_JUKART_Human1.58506878
42NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.58326340
43IRF8_27001747_Chip-Seq_BMDM_Mouse1.58265660
44ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.54351460
45PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.53804749
46SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.51385252
47IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.51201542
48RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.48690174
49KDM2B_26808549_Chip-Seq_DND41_Human1.48329305
50SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.48141294
51SALL4_18804426_ChIP-ChIP_XEN_Mouse1.42768506
52* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.42445429
53* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.42237643
54IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.41693523
55STAT4_19710469_ChIP-ChIP_TH1__Mouse1.41433155
56* SPI1_23547873_ChIP-Seq_NB4_Human1.39419654
57PPARA_22158963_ChIP-Seq_LIVER_Mouse1.37205114
58CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.36742830
59RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.36682834
60* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.36427026
61ELK1_19687146_ChIP-ChIP_HELA_Human1.34632940
62IRF8_21731497_ChIP-ChIP_J774_Mouse1.33515487
63* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.32692545
64AR_21909140_ChIP-Seq_LNCAP_Human1.32370022
65NELFA_20434984_ChIP-Seq_ESCs_Mouse1.30947356
66SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.30892041
67ESR1_20079471_ChIP-ChIP_T-47D_Human1.30556432
68FOXO3_23340844_ChIP-Seq_DLD1_Human1.29458833
69STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.28913863
70* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.28413659
71* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.28151681
72FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.28136119
73ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.27505815
74* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.27372014
75NCOR1_26117541_ChIP-Seq_K562_Human1.27351613
76* GATA6_25053715_ChIP-Seq_YYC3_Human1.25974569
77MYC_19030024_ChIP-ChIP_MESCs_Mouse1.25291503
78HOXB4_20404135_ChIP-ChIP_EML_Mouse1.24407382
79KDM2B_26808549_Chip-Seq_SUP-B15_Human1.23044596
80MYC_19079543_ChIP-ChIP_MESCs_Mouse1.22941962
81MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.22825741
82HIF1A_21447827_ChIP-Seq_MCF-7_Human1.20099572
83TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19803530
84KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.19631232
85* ATF3_27146783_Chip-Seq_COLON_Human1.18830778
86RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.18169974
87* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.14776702
88ERG_20887958_ChIP-Seq_HPC-7_Mouse1.14751797
89ZNF263_19887448_ChIP-Seq_K562_Human1.14641230
90SPI1_23127762_ChIP-Seq_K562_Human1.14276691
91GATA3_27048872_Chip-Seq_THYMUS_Human1.14253550
92* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.14142231
93E2F4_17652178_ChIP-ChIP_JURKAT_Human1.13818073
94* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.13713611
95DCP1A_22483619_ChIP-Seq_HELA_Human1.13322913
96PU_27001747_Chip-Seq_BMDM_Mouse1.13165312
97FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.12923188
98HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.12533066
99E2F1_21310950_ChIP-Seq_MCF-7_Human1.12188749
100CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.12163146
101RXR_22158963_ChIP-Seq_LIVER_Mouse1.12041301
102FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.11608207
103* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.10548591
104* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.09506415
105RARG_19884340_ChIP-ChIP_MEFs_Mouse1.09466911
106CIITA_25753668_ChIP-Seq_RAJI_Human1.09150208
107SALL1_21062744_ChIP-ChIP_HESCs_Human1.08640949
108MAF_26560356_Chip-Seq_TH2_Human1.08479318
109TFEB_21752829_ChIP-Seq_HELA_Human1.08074055
110* ELF5_23300383_ChIP-Seq_T47D_Human1.07981222
111FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.06935500
112HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.06578686
113RACK7_27058665_Chip-Seq_MCF-7_Human1.06077169
114CHD1_26751641_Chip-Seq_LNCaP_Human1.05911484
115PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.05845872
116YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.05543725
117CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.04467057
118TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04129563
119GATA1_19941826_ChIP-Seq_K562_Human1.03929498
120TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.03898171
121FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.03761828
122GATA2_21666600_ChIP-Seq_HMVEC_Human1.03184586
123PPAR_26484153_Chip-Seq_NCI-H1993_Human1.03096312
124* GATA1_19941827_ChIP-Seq_MEL_Mouse1.02267636
125KLF4_18555785_ChIP-Seq_MESCs_Mouse1.02175566
126BP1_19119308_ChIP-ChIP_Hs578T_Human1.01717107
127SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.01008308
128SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.01008308
129P300_27058665_Chip-Seq_ZR-75-30cells_Human1.00058566
130GATA3_24758297_ChIP-Seq_MCF-7_Human0.98879851
131LXR_22158963_ChIP-Seq_LIVER_Mouse0.98755038
132* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.98630281
133GATA2_19941826_ChIP-Seq_K562_Human0.97635511
134TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97101131
135CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.96916548
136Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.96823737
137STAT3_1855785_ChIP-Seq_MESCs_Mouse0.96809607
138MYC_18358816_ChIP-ChIP_MESCs_Mouse0.96061134
139STAT6_21828071_ChIP-Seq_BEAS2B_Human0.95375529
140TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95225520
141EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.94718661
142* BRD4_25478319_ChIP-Seq_HGPS_Human0.94083011

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003300_gastrointestinal_ulcer3.30581370
2MP0010352_gastrointestinal_tract_polyps2.93903414
3MP0002009_preneoplasia2.77297336
4MP0003705_abnormal_hypodermis_morpholog2.52316481
5MP0010234_abnormal_vibrissa_follicle2.50401075
6MP0002796_impaired_skin_barrier2.43683190
7MP0002396_abnormal_hematopoietic_system2.38461125
8MP0006054_spinal_hemorrhage2.36039527
9MP0008057_abnormal_DNA_replication2.10265924
10MP0005076_abnormal_cell_differentiation2.07261811
11MP0002166_altered_tumor_susceptibility2.03957756
12MP0003303_peritoneal_inflammation2.02810060
13MP0004264_abnormal_extraembryonic_tissu1.99251809
14MP0002877_abnormal_melanocyte_morpholog1.96615363
15MP0003566_abnormal_cell_adhesion1.90930837
16MP0004808_abnormal_hematopoietic_stem1.87404739
17MP0003436_decreased_susceptibility_to1.86857376
18MP0000685_abnormal_immune_system1.86587414
19MP0003950_abnormal_plasma_membrane1.83471367
20MP0005501_abnormal_skin_physiology1.75317159
21MP0001873_stomach_inflammation1.71777786
22MP0004782_abnormal_surfactant_physiolog1.70007251
23MP0001835_abnormal_antigen_presentation1.67967549
24MP0010155_abnormal_intestine_physiology1.65458232
25MP0000490_abnormal_crypts_of1.59358231
26MP0009278_abnormal_bone_marrow1.58633455
27MP0010678_abnormal_skin_adnexa1.58378508
28MP0004947_skin_inflammation1.58174638
29MP0005397_hematopoietic_system_phenotyp1.56582839
30MP0001545_abnormal_hematopoietic_system1.56582839
31MP0003763_abnormal_thymus_physiology1.56264575
32MP0003828_pulmonary_edema1.55823647
33MP0001800_abnormal_humoral_immune1.50881867
34MP0003111_abnormal_nucleus_morphology1.50522099
35MP0002006_tumorigenesis1.49264212
36MP0002138_abnormal_hepatobiliary_system1.48022132
37MP0005464_abnormal_platelet_physiology1.44988612
38MP0002398_abnormal_bone_marrow1.43440884
39MP0005023_abnormal_wound_healing1.42731921
40MP0009697_abnormal_copulation1.42698878
41MP0010094_abnormal_chromosome_stability1.42016755
42MP0002452_abnormal_antigen_presenting1.41183804
43MP0005387_immune_system_phenotype1.39556052
44MP0001790_abnormal_immune_system1.39556052
45MP0000465_gastrointestinal_hemorrhage1.37204385
46MP0010307_abnormal_tumor_latency1.36839678
47MP0003941_abnormal_skin_development1.34143608
48MP0002405_respiratory_system_inflammati1.30081278
49MP0002420_abnormal_adaptive_immunity1.29075456
50MP0001819_abnormal_immune_cell1.28393242
51MP0005000_abnormal_immune_tolerance1.27979673
52MP0005025_abnormal_response_to1.27693387
53MP0001533_abnormal_skeleton_physiology1.26520788
54MP0002723_abnormal_immune_serum1.24460493
55MP0002419_abnormal_innate_immunity1.23690223
56MP0005671_abnormal_response_to1.22963521
57MP0008007_abnormal_cellular_replicative1.22131490
58MP0003866_abnormal_defecation1.20529160
59MP0002722_abnormal_immune_system1.20237825
60MP0001730_embryonic_growth_arrest1.19718003
61MP0000858_altered_metastatic_potential1.19354132
62MP0000716_abnormal_immune_system1.18458134
63MP0008438_abnormal_cutaneous_collagen1.16754121
64MP0000689_abnormal_spleen_morphology1.16205583
65MP0009785_altered_susceptibility_to1.15518627
66MP0001845_abnormal_inflammatory_respons1.14716088
67MP0001851_eye_inflammation1.12922200
68MP0002933_joint_inflammation1.11549001
69MP0003252_abnormal_bile_duct1.10964925
70MP0002139_abnormal_hepatobiliary_system1.10209362
71MP0009333_abnormal_splenocyte_physiolog1.09786077
72MP0002429_abnormal_blood_cell1.09614620
73MP0003656_abnormal_erythrocyte_physiolo1.08471827
74MP0000569_abnormal_digit_pigmentation1.08227555
75MP0000703_abnormal_thymus_morphology1.07774524
76MP0000383_abnormal_hair_follicle1.01655294
77MP0003693_abnormal_embryo_hatching1.00626550
78MP0005310_abnormal_salivary_gland0.98423513
79MP0003453_abnormal_keratinocyte_physiol0.98352841
80MP0005621_abnormal_cell_physiology0.97804446
81MP0001672_abnormal_embryogenesis/_devel0.97725611
82MP0005380_embryogenesis_phenotype0.97725611
83MP0005451_abnormal_body_composition0.96942243
84MP0000477_abnormal_intestine_morphology0.96918445
85MP0001853_heart_inflammation0.94862499
86MP0000733_abnormal_muscle_development0.93734257
87MP0008058_abnormal_DNA_repair0.93085738
88MP0001881_abnormal_mammary_gland0.92577338
89MP0002086_abnormal_extraembryonic_tissu0.92460858
90MP0003943_abnormal_hepatobiliary_system0.91871213
91MP0002019_abnormal_tumor_incidence0.90758705
92MP0008004_abnormal_stomach_pH0.90368000
93MP0000609_abnormal_liver_physiology0.89919038
94MP0003448_altered_tumor_morphology0.88697712
95MP0002080_prenatal_lethality0.88361537
96MP0001666_abnormal_nutrient_absorption0.88193147
97MP0003806_abnormal_nucleotide_metabolis0.88166562
98MP0009840_abnormal_foam_cell0.88116850
99MP0003718_maternal_effect0.88108529
100MP0004185_abnormal_adipocyte_glucose0.88011851
101MP0000627_abnormal_mammary_gland0.87854713
102MP0003091_abnormal_cell_migration0.87821131
103MP0005360_urolithiasis0.86956433
104MP0000350_abnormal_cell_proliferation0.85933551
105MP0001915_intracranial_hemorrhage0.85716569
106MP0005058_abnormal_lysosome_morphology0.85690183
107MP0001697_abnormal_embryo_size0.84277572
108MP0003279_aneurysm0.84120551
109MP0002148_abnormal_hypersensitivity_rea0.83858151
110MP0003795_abnormal_bone_structure0.83689262
111MP0009931_abnormal_skin_appearance0.83416179
112MP0002060_abnormal_skin_morphology0.83146691
113MP0003191_abnormal_cellular_cholesterol0.83119120
114MP0002088_abnormal_embryonic_growth/wei0.82322206
115MP0003984_embryonic_growth_retardation0.81892677
116MP0002998_abnormal_bone_remodeling0.81716454
117MP0004197_abnormal_fetal_growth/weight/0.81284082
118MP0004957_abnormal_blastocyst_morpholog0.80587460
119MP0006082_CNS_inflammation0.79337722
120MP0003077_abnormal_cell_cycle0.79116129
121MP0002132_abnormal_respiratory_system0.78987056
122MP0000598_abnormal_liver_morphology0.78873337
123MP0000537_abnormal_urethra_morphology0.78613450
124MP0003868_abnormal_feces_composition0.78186861
125MP0001849_ear_inflammation0.78170917
126MP0008469_abnormal_protein_level0.77666260
127MP0004272_abnormal_basement_membrane0.77296985
128MP0005275_abnormal_skin_tensile0.77059252
129MP0003221_abnormal_cardiomyocyte_apopto0.76207223
130MP0001663_abnormal_digestive_system0.75248865
131MP0003724_increased_susceptibility_to0.75178530
132MP0008932_abnormal_embryonic_tissue0.74104456
133MP0002928_abnormal_bile_duct0.74029906
134MP0001216_abnormal_epidermal_layer0.73918886
135MP0002098_abnormal_vibrissa_morphology0.73620039
136MP0000377_abnormal_hair_follicle0.73000304
137MP0010771_integument_phenotype0.72283392
138MP0005165_increased_susceptibility_to0.71723430
139MP0001661_extended_life_span0.71509418
140MP0005384_cellular_phenotype0.69571190

Predicted human phenotypes

RankGene SetZ-score
1Lip pit (HP:0100267)3.20883617
2Right ventricular cardiomyopathy (HP:0011663)3.12171331
3Aortic aneurysm (HP:0004942)2.89283851
4Increased density of long bones (HP:0006392)2.88115083
5Chronic bronchitis (HP:0004469)2.82790739
6Abnormality of the fingertips (HP:0001211)2.82269408
7Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.79132175
8Recurrent viral infections (HP:0004429)2.78655327
9Curly hair (HP:0002212)2.68626946
10Eczematoid dermatitis (HP:0000976)2.61129149
11Short middle phalanx of the 5th finger (HP:0004220)2.60256198
12Thrombocytosis (HP:0001894)2.58646542
13Subacute progressive viral hepatitis (HP:0006572)2.58089567
14IgM deficiency (HP:0002850)2.57318901
15Selective tooth agenesis (HP:0001592)2.55766011
16Abnormality of monocarboxylic acid metabolism (HP:0010996)2.51355875
17Hematochezia (HP:0002573)2.49636556
18Cervical subluxation (HP:0003308)2.49322673
19Recurrent fungal infections (HP:0002841)2.47585856
20Cellulitis (HP:0100658)2.47445667
21Cerebral aneurysm (HP:0004944)2.45124954
22Hyperactive renin-angiotensin system (HP:0000841)2.42661174
23Protrusio acetabuli (HP:0003179)2.40635762
24Papillary thyroid carcinoma (HP:0002895)2.40218920
25Tetraparesis (HP:0002273)2.37234794
26Deep philtrum (HP:0002002)2.36146599
27Abnormal platelet function (HP:0011869)2.34523181
28Impaired platelet aggregation (HP:0003540)2.34523181
29Rectal prolapse (HP:0002035)2.33366546
30Abnormal platelet volume (HP:0011876)2.30368188
31Rhinitis (HP:0012384)2.29710762
32Mitral valve prolapse (HP:0001634)2.26569865
33Autoimmune hemolytic anemia (HP:0001890)2.26394586
34Increased mean platelet volume (HP:0011877)2.23032072
35Abnormal foot bone ossification (HP:0010675)2.22697702
36Onycholysis (HP:0001806)2.21450594
37Flat acetabular roof (HP:0003180)2.20869566
38Abnormality of the distal phalanges of the toes (HP:0010182)2.20324386
39Autoimmune thrombocytopenia (HP:0001973)2.17604685
40Abnormality of small intestinal villus morphology (HP:0011472)2.17097577
41Villous atrophy (HP:0011473)2.17097577
42Pustule (HP:0200039)2.17045221
43Osteolytic defects of the hand bones (HP:0009699)2.14700679
44Osteolytic defects of the phalanges of the hand (HP:0009771)2.14700679
45T lymphocytopenia (HP:0005403)2.14196194
46Spontaneous hematomas (HP:0007420)2.13361507
47Aortic dissection (HP:0002647)2.11265814
48Persistence of primary teeth (HP:0006335)2.10403163
49Trismus (HP:0000211)2.09148407
50Acute lymphatic leukemia (HP:0006721)2.09092541
51Periodontitis (HP:0000704)2.08911014
52Male infertility (HP:0003251)2.08393094
53Ulnar bowing (HP:0003031)2.07816821
54Petechiae (HP:0000967)2.07739712
55Interstitial pulmonary disease (HP:0006530)2.07451155
56Deviation of the thumb (HP:0009603)2.05993218
57Coarse hair (HP:0002208)2.05238206
58Aneurysm (HP:0002617)2.04079875
59Ankyloglossia (HP:0010296)2.02143324
60Chronic otitis media (HP:0000389)2.00891437
61Vertebral compression fractures (HP:0002953)2.00798955
62Exostoses (HP:0100777)2.00560105
63Abnormality of T cell number (HP:0011839)1.98651087
64Epiphyseal dysplasia (HP:0002656)1.98115735
65Bronchiectasis (HP:0002110)1.97347278
66Myositis (HP:0100614)1.97064341
67Blepharitis (HP:0000498)1.96620076
68Papilloma (HP:0012740)1.96553827
69Verrucae (HP:0200043)1.96553827
70Arterial thrombosis (HP:0004420)1.96187199
71Spondylolisthesis (HP:0003302)1.94814632
72Recurrent bronchitis (HP:0002837)1.93662108
73Dilatation of the ascending aorta (HP:0005111)1.92373361
74Micronodular cirrhosis (HP:0001413)1.90899570
75Volvulus (HP:0002580)1.90577806
76Thin bony cortex (HP:0002753)1.90481116
77Abnormality of the thoracic spine (HP:0100711)1.90169202
78Nasal polyposis (HP:0100582)1.89542786
79Abnormality of the common coagulation pathway (HP:0010990)1.89454747
80Gastrointestinal inflammation (HP:0004386)1.89353753
81Recurrent bacterial skin infections (HP:0005406)1.89241761
82Progressive hearing impairment (HP:0001730)1.89062984
83Seborrheic dermatitis (HP:0001051)1.88975326
84Vascular calcification (HP:0004934)1.87982338
85Recurrent abscess formation (HP:0002722)1.87600048
86Progressive muscle weakness (HP:0003323)1.87032627
87Severe short stature (HP:0003510)1.86806611
88Inflammation of the large intestine (HP:0002037)1.86338588
89Abnormality of T cells (HP:0002843)1.86049618
90Abnormal respiratory motile cilium physiology (HP:0012261)1.85862699
91Septate vagina (HP:0001153)1.85748357
92Viral hepatitis (HP:0006562)1.85481831
93Multiple enchondromatosis (HP:0005701)1.85404131
94Cardiovascular calcification (HP:0011915)1.84537526
95Prolonged bleeding time (HP:0003010)1.84182591
96Metaphyseal cupping (HP:0003021)1.83202456
97Glucose intolerance (HP:0000833)1.82873107
98Broad palm (HP:0001169)1.82489636
99Erythema (HP:0010783)1.82419230
100Macroorchidism (HP:0000053)1.81797163
101Radial bowing (HP:0002986)1.81272908
102Spinal cord lesions (HP:0100561)1.80992369
103Syringomyelia (HP:0003396)1.80992369
104Colitis (HP:0002583)1.79033287
105Thyroid carcinoma (HP:0002890)1.79015564
106Acute myeloid leukemia (HP:0004808)1.78872860
107Neonatal hypoglycemia (HP:0001998)1.78235872
108Proximal placement of thumb (HP:0009623)1.77793706
109Absent/shortened dynein arms (HP:0200106)1.76819358
110Dynein arm defect of respiratory motile cilia (HP:0012255)1.76819358
111Abnormality of T cell physiology (HP:0011840)1.76762144
112Arterial tortuosity (HP:0005116)1.76674186
113Increased IgE level (HP:0003212)1.76210324
114Abnormal hair laboratory examination (HP:0003328)1.76151274
115Cutaneous melanoma (HP:0012056)1.76105890
116Gonadal dysgenesis (HP:0000133)1.76054663
117Peritonitis (HP:0002586)1.75784136
118Abnormality of the nasal mucosa (HP:0000433)1.75275764
119Thoracic kyphosis (HP:0002942)1.74411161
120Osteomyelitis (HP:0002754)1.73749554
121Thoracolumbar scoliosis (HP:0002944)1.73457349
122Bronchitis (HP:0012387)1.73367524
123Alopecia of scalp (HP:0002293)1.72853277
124IgA deficiency (HP:0002720)1.72476689
125Gingival bleeding (HP:0000225)1.72038144
126Abnormality of oral frenula (HP:0000190)1.71548922
127Bicuspid aortic valve (HP:0001647)1.71476867
128Abnormal glucose tolerance (HP:0001952)1.71417129
129Nonimmune hydrops fetalis (HP:0001790)1.71253250
130Thick nail (HP:0001805)1.70999395
131Popliteal pterygium (HP:0009756)1.70352290
132Myocardial infarction (HP:0001658)1.70281794
133Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.69591321
134Epistaxis (HP:0000421)1.69416243
135Acanthocytosis (HP:0001927)1.68587810
136Asymmetry of the thorax (HP:0001555)1.68428991
137Fatigue (HP:0012378)1.67206011
138Cupped ribs (HP:0000887)1.66762329
139Biliary tract neoplasm (HP:0100574)1.66586971
140Prominent nose (HP:0000448)1.66120567
141Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.65734304
142Hyperacusis (HP:0010780)1.65580392
143Chest pain (HP:0100749)1.64877782
144Ankle contracture (HP:0006466)1.64114262
145Palmoplantar hyperkeratosis (HP:0000972)1.64080655
146Hypobetalipoproteinemia (HP:0003563)1.63681435
147Abnormal delayed hypersensitivity skin test (HP:0002963)1.62878007
148Palmar hyperkeratosis (HP:0010765)1.62837021
149Premature rupture of membranes (HP:0001788)1.62498049
150Ulnar deviation of the wrist (HP:0003049)1.61348259
151Disproportionate tall stature (HP:0001519)1.61055182
152High pitched voice (HP:0001620)1.60782697
153Abnormality of nail color (HP:0100643)1.60602350
154Short 4th metacarpal (HP:0010044)1.60475303
155Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.60475303
156Malignant gastrointestinal tract tumors (HP:0006749)1.60199554
157Gastrointestinal carcinoma (HP:0002672)1.60199554
158Testicular neoplasm (HP:0010788)1.59781566
159Abnormality of the acetabulum (HP:0003170)1.59632735
160B lymphocytopenia (HP:0010976)1.59410430
161Abnormality of B cell number (HP:0010975)1.59410430
162Esophageal varix (HP:0002040)1.58860079
163Relative macrocephaly (HP:0004482)1.58831335
164Genu recurvatum (HP:0002816)1.58362117
165Elevated erythrocyte sedimentation rate (HP:0003565)1.57166589
166Premature ovarian failure (HP:0008209)1.55034685
167Abnormality of the pancreatic islet cells (HP:0006476)1.53030437
168Abnormality of endocrine pancreas physiology (HP:0012093)1.53030437
169Abnormal respiratory motile cilium morphology (HP:0005938)1.51515986
170Abnormal respiratory epithelium morphology (HP:0012253)1.51515986
171Abnormality of the gastric mucosa (HP:0004295)1.51231328
172Centrally nucleated skeletal muscle fibers (HP:0003687)1.51049063
173Plantar hyperkeratosis (HP:0007556)1.50001633
174Fat malabsorption (HP:0002630)1.49979882
175Malnutrition (HP:0004395)1.49895579

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EEF2K3.37736213
2TRIB33.26279166
3PKN23.20666014
4MAP3K102.91900091
5ERN12.70310249
6STK102.58772098
7MAP4K12.51355141
8EIF2AK12.38425228
9EIF2AK32.33560070
10TAOK32.32164445
11PTK62.16010357
12MST1R2.10274162
13STK32.09869376
14CDK121.96702112
15LRRK21.90582392
16RIPK11.80475103
17JAK31.76745353
18PBK1.76522224
19SIK11.72728755
20TTK1.61495948
21PIK3CG1.59121720
22TYK21.57185096
23FRK1.56670183
24FLT31.54780624
25CDK61.48800314
26ZAP701.47743140
27SRPK11.45074390
28SCYL21.42198720
29MAP2K31.41847468
30NEK11.40549911
31RPS6KA41.39413600
32TBK11.35906390
33TTN1.35472150
34SMG11.34070678
35GRK61.31198630
36BTK1.30256247
37RPS6KB21.29764361
38FGFR41.25702259
39LATS11.24893105
40EPHB11.23324272
41JAK11.20659723
42FGFR31.20534865
43TGFBR21.20087751
44ITK1.19345697
45PRPF4B1.14515789
46MAP3K131.12391089
47CDK41.09811011
48SIK31.09479967
49PIM11.09232751
50MAP3K141.07555572
51DMPK1.07089025
52TXK1.04960632
53MKNK11.04746820
54MAP3K81.04705721
55MET1.00519042
56ERBB30.99402013
57STK240.99142224
58KIT0.98857152
59BMPR20.98731810
60MST40.95553831
61CAMK1D0.95463284
62MAP3K30.94198716
63CSF1R0.93063165
64TRPM70.92518020
65CHUK0.91247576
66NEK20.89903911
67BLK0.88608015
68EPHA30.87973648
69JAK20.87046274
70TAOK10.85933142
71PAK40.85121218
72PDGFRA0.84692708
73MTOR0.84612072
74TEC0.84187504
75CSK0.84041659
76ALK0.82316828
77PTK20.81187110
78STK40.78224310
79TGFBR10.77935443
80IKBKE0.77199093
81NLK0.76995048
82PDGFRB0.76888089
83NEK90.75776405
84PAK20.75321522
85CDC70.75106889
86PDK20.74743404
87EIF2AK20.73847293
88BMX0.73466761
89EPHA20.73288639
90CHEK10.71767852
91MATK0.69652289
92HCK0.69368109
93MAP3K120.66594150
94ERBB40.66581159
95CDK80.65792299
96LCK0.65242280
97YES10.65169641
98IKBKB0.64542447
99PIM20.61404949
100LMTK20.61023173
101AKT30.60119580
102MAP3K10.59976992
103MAPKAPK30.59732433
104BRSK20.59388286
105CAMK1G0.58855633
106STK38L0.58691664
107CDK90.58689915
108SYK0.58215310
109IRAK10.57435267
110IRAK40.56746756
111AURKB0.56503362
112MAP3K70.54890340
113NUAK10.54584510
114MAP3K60.53546537
115NME20.53531080
116CDK70.52181830
117HIPK20.51691861
118RET0.51275330
119MKNK20.50927701
120PASK0.49543055
121IRAK30.49198431
122ILK0.48794138
123MARK30.47887614
124FER0.47787942
125PRKG20.47265491
126DDR20.45868427
127FGFR10.45400924
128ATR0.43921692
129MAPKAPK20.43844560
130MELK0.43203312
131EGFR0.42307076
132BRD40.41548311
133MAP2K20.41315267
134PRKAA20.41057538
135CLK10.40804900
136ATM0.40407126
137ICK0.40298519
138MOS0.39699682
139MAPK110.38578347
140CHEK20.38035880
141MAP3K20.33836925

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.02354752
2Chronic myeloid leukemia_Homo sapiens_hsa052202.00327910
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.84589667
4Antigen processing and presentation_Homo sapiens_hsa046121.83461252
5Osteoclast differentiation_Homo sapiens_hsa043801.75225777
6NF-kappa B signaling pathway_Homo sapiens_hsa040641.72734489
7B cell receptor signaling pathway_Homo sapiens_hsa046621.69121089
8Caffeine metabolism_Homo sapiens_hsa002321.68887139
9DNA replication_Homo sapiens_hsa030301.67829942
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.66047632
11Toxoplasmosis_Homo sapiens_hsa051451.65759393
12Small cell lung cancer_Homo sapiens_hsa052221.62278133
13Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.59746892
14Non-homologous end-joining_Homo sapiens_hsa034501.58714143
15Acute myeloid leukemia_Homo sapiens_hsa052211.56760040
16Measles_Homo sapiens_hsa051621.56746003
17Primary immunodeficiency_Homo sapiens_hsa053401.56626255
18Leukocyte transendothelial migration_Homo sapiens_hsa046701.50608098
19Sulfur metabolism_Homo sapiens_hsa009201.49796796
20Spliceosome_Homo sapiens_hsa030401.48174462
21Pancreatic cancer_Homo sapiens_hsa052121.42508725
22Legionellosis_Homo sapiens_hsa051341.39056178
23Hepatitis B_Homo sapiens_hsa051611.37114498
24RNA transport_Homo sapiens_hsa030131.35746572
25Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.35312567
26Intestinal immune network for IgA production_Homo sapiens_hsa046721.34778435
27Hematopoietic cell lineage_Homo sapiens_hsa046401.32379157
28AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.32335656
29Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.29723212
30TNF signaling pathway_Homo sapiens_hsa046681.27466117
31Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.23867558
32Nucleotide excision repair_Homo sapiens_hsa034201.22966804
33Herpes simplex infection_Homo sapiens_hsa051681.21772745
34Pentose and glucuronate interconversions_Homo sapiens_hsa000401.20247734
35NOD-like receptor signaling pathway_Homo sapiens_hsa046211.20018241
36Apoptosis_Homo sapiens_hsa042101.19955734
37Mismatch repair_Homo sapiens_hsa034301.19234667
38T cell receptor signaling pathway_Homo sapiens_hsa046601.19097338
39Toll-like receptor signaling pathway_Homo sapiens_hsa046201.16303263
40Insulin resistance_Homo sapiens_hsa049311.16088647
41Drug metabolism - other enzymes_Homo sapiens_hsa009831.15512620
42Platelet activation_Homo sapiens_hsa046111.15286767
43Jak-STAT signaling pathway_Homo sapiens_hsa046301.14478751
44Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.14270036
45Viral carcinogenesis_Homo sapiens_hsa052031.14015523
46Proteoglycans in cancer_Homo sapiens_hsa052051.12825703
47Lysine degradation_Homo sapiens_hsa003101.12570707
48Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.12433126
49Viral myocarditis_Homo sapiens_hsa054161.11742801
50Adherens junction_Homo sapiens_hsa045201.11373916
51Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.09687291
52Transcriptional misregulation in cancer_Homo sapiens_hsa052021.08901880
53Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.08560682
54MicroRNAs in cancer_Homo sapiens_hsa052061.07847471
55Non-small cell lung cancer_Homo sapiens_hsa052231.07407838
56Influenza A_Homo sapiens_hsa051641.07368420
57Focal adhesion_Homo sapiens_hsa045101.05871069
58Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.04294676
59Thyroid cancer_Homo sapiens_hsa052161.01985587
60mRNA surveillance pathway_Homo sapiens_hsa030151.01009219
61Circadian rhythm_Homo sapiens_hsa047101.00515084
62RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.99383669
63Shigellosis_Homo sapiens_hsa051310.99095707
64Staphylococcus aureus infection_Homo sapiens_hsa051500.97302172
65Prolactin signaling pathway_Homo sapiens_hsa049170.96720664
66Selenocompound metabolism_Homo sapiens_hsa004500.96613987
67Bladder cancer_Homo sapiens_hsa052190.95466571
68Chemical carcinogenesis_Homo sapiens_hsa052040.94531039
69HTLV-I infection_Homo sapiens_hsa051660.94459002
70ECM-receptor interaction_Homo sapiens_hsa045120.93873397
71Amoebiasis_Homo sapiens_hsa051460.93849160
72Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.93114921
73Sphingolipid metabolism_Homo sapiens_hsa006000.92666107
74Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.92608674
75Hepatitis C_Homo sapiens_hsa051600.92571815
76Neurotrophin signaling pathway_Homo sapiens_hsa047220.92516567
77One carbon pool by folate_Homo sapiens_hsa006700.92111862
78Colorectal cancer_Homo sapiens_hsa052100.92035445
79mTOR signaling pathway_Homo sapiens_hsa041500.91813344
80Retinol metabolism_Homo sapiens_hsa008300.91286452
81Tuberculosis_Homo sapiens_hsa051520.91167877
82Prostate cancer_Homo sapiens_hsa052150.91006295
83Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.90430993
84N-Glycan biosynthesis_Homo sapiens_hsa005100.88754293
85Renin-angiotensin system_Homo sapiens_hsa046140.87607034
86Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.86774141
87Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.86140242
88Base excision repair_Homo sapiens_hsa034100.85445365
89Pertussis_Homo sapiens_hsa051330.84274686
90Endometrial cancer_Homo sapiens_hsa052130.83405930
91Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.82282168
92Malaria_Homo sapiens_hsa051440.81901170
93p53 signaling pathway_Homo sapiens_hsa041150.81328410
94Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.80829571
95Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.80308269
96Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.79239280
97Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.78545867
98Histidine metabolism_Homo sapiens_hsa003400.77981065
99Phenylalanine metabolism_Homo sapiens_hsa003600.76884083
100Fatty acid degradation_Homo sapiens_hsa000710.75788176
101FoxO signaling pathway_Homo sapiens_hsa040680.73683925
102Carbohydrate digestion and absorption_Homo sapiens_hsa049730.73001566
103Adipocytokine signaling pathway_Homo sapiens_hsa049200.72880944
104Cell cycle_Homo sapiens_hsa041100.71158809
105Central carbon metabolism in cancer_Homo sapiens_hsa052300.70521428
106Glutathione metabolism_Homo sapiens_hsa004800.69503232
107Nitrogen metabolism_Homo sapiens_hsa009100.69391073
108Carbon metabolism_Homo sapiens_hsa012000.69225444
109Protein digestion and absorption_Homo sapiens_hsa049740.68816628
110Chemokine signaling pathway_Homo sapiens_hsa040620.65737544
111Steroid hormone biosynthesis_Homo sapiens_hsa001400.64160136
112Fructose and mannose metabolism_Homo sapiens_hsa000510.64062513
113VEGF signaling pathway_Homo sapiens_hsa043700.63508091
114Epstein-Barr virus infection_Homo sapiens_hsa051690.62563300
115Inositol phosphate metabolism_Homo sapiens_hsa005620.62204153
116Galactose metabolism_Homo sapiens_hsa000520.60260779
117Other glycan degradation_Homo sapiens_hsa005110.59502166
118HIF-1 signaling pathway_Homo sapiens_hsa040660.58876559
119Homologous recombination_Homo sapiens_hsa034400.58036525
120Biosynthesis of amino acids_Homo sapiens_hsa012300.57717655
121Pyrimidine metabolism_Homo sapiens_hsa002400.57369178
122ABC transporters_Homo sapiens_hsa020100.55841164
123Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.55288930
124Pathways in cancer_Homo sapiens_hsa052000.53952954
125Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.53464207
126Salmonella infection_Homo sapiens_hsa051320.53102994
127Tyrosine metabolism_Homo sapiens_hsa003500.52571682
128Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.52335173
129Cysteine and methionine metabolism_Homo sapiens_hsa002700.51335458
130Regulation of actin cytoskeleton_Homo sapiens_hsa048100.51289724
131RNA degradation_Homo sapiens_hsa030180.50431599
132Starch and sucrose metabolism_Homo sapiens_hsa005000.50383093
133Notch signaling pathway_Homo sapiens_hsa043300.50370611
134Pentose phosphate pathway_Homo sapiens_hsa000300.49794219
135Glycosaminoglycan degradation_Homo sapiens_hsa005310.49338585
136AMPK signaling pathway_Homo sapiens_hsa041520.48577045
137TGF-beta signaling pathway_Homo sapiens_hsa043500.48487145
138Renal cell carcinoma_Homo sapiens_hsa052110.46536804
139Thyroid hormone signaling pathway_Homo sapiens_hsa049190.46368606
140PI3K-Akt signaling pathway_Homo sapiens_hsa041510.45537856

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