CLIP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the cytoplasmic linker protein 170 family. Members of this protein family contain a cytoskeleton-associated protein glycine-rich domain and mediate the interaction of microtubules with cellular organelles. The encoded protein plays a role in T cell apoptosis by facilitating the association of tubulin and the lipid raft ganglioside GD3. The encoded protein also functions as a scaffold protein mediating membrane localization of phosphorylated protein kinase B. Alternatively spliced transcript variants have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.09065321
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.75915613
3locomotory exploration behavior (GO:0035641)5.52526407
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.50520259
5synaptic vesicle exocytosis (GO:0016079)5.48889431
6vocalization behavior (GO:0071625)5.21543771
7glutamate secretion (GO:0014047)5.21522616
8positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.14575389
9regulation of synaptic vesicle exocytosis (GO:2000300)5.02853039
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.86678385
11neuron cell-cell adhesion (GO:0007158)4.64150051
12protein localization to synapse (GO:0035418)4.54601468
13layer formation in cerebral cortex (GO:0021819)4.48119273
14regulation of glutamate receptor signaling pathway (GO:1900449)4.40994511
15neurotransmitter secretion (GO:0007269)4.39952919
16regulation of synaptic vesicle transport (GO:1902803)4.38538137
17exploration behavior (GO:0035640)4.37680941
18neuronal action potential propagation (GO:0019227)4.35600286
19synaptic vesicle docking involved in exocytosis (GO:0016081)4.34429072
20ionotropic glutamate receptor signaling pathway (GO:0035235)4.29841501
21gamma-aminobutyric acid transport (GO:0015812)4.08835004
22regulation of synapse structural plasticity (GO:0051823)4.08132077
23regulation of neuronal synaptic plasticity (GO:0048168)4.06741719
24dendritic spine morphogenesis (GO:0060997)4.05277287
25central nervous system myelination (GO:0022010)4.04977140
26axon ensheathment in central nervous system (GO:0032291)4.04977140
27regulation of long-term neuronal synaptic plasticity (GO:0048169)4.02356638
28cellular potassium ion homeostasis (GO:0030007)4.02098303
29response to pheromone (GO:0019236)3.94309387
30synaptic transmission, glutamatergic (GO:0035249)3.94076506
31glutamate receptor signaling pathway (GO:0007215)3.88381841
32cerebellar granule cell differentiation (GO:0021707)3.83767219
33amino acid import (GO:0043090)3.78690155
34sodium ion export (GO:0071436)3.75630959
35positive regulation of synapse maturation (GO:0090129)3.75330675
36neuron-neuron synaptic transmission (GO:0007270)3.72232379
37cerebellar Purkinje cell differentiation (GO:0021702)3.71619954
38neuron recognition (GO:0008038)3.70515938
39dendrite morphogenesis (GO:0048813)3.66725393
40positive regulation of dendritic spine morphogenesis (GO:0061003)3.64929759
41long-term memory (GO:0007616)3.63231441
42neurotransmitter transport (GO:0006836)3.60511948
43neurotransmitter-gated ion channel clustering (GO:0072578)3.57352698
44regulation of voltage-gated calcium channel activity (GO:1901385)3.51606708
45synaptic vesicle endocytosis (GO:0048488)3.49742128
46positive regulation of membrane potential (GO:0045838)3.48574511
47axonal fasciculation (GO:0007413)3.48155045
48regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.47500895
49regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.47308193
50membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.45086834
51transmission of nerve impulse (GO:0019226)3.44816912
52positive regulation of neurotransmitter transport (GO:0051590)3.44374443
53potassium ion import (GO:0010107)3.44328867
54regulation of excitatory postsynaptic membrane potential (GO:0060079)3.43964941
55establishment of mitochondrion localization (GO:0051654)3.43912138
56proline transport (GO:0015824)3.43507270
57positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.42538467
58cell migration in hindbrain (GO:0021535)3.40540388
59regulation of neurotransmitter secretion (GO:0046928)3.38932707
60auditory behavior (GO:0031223)3.35185741
61gamma-aminobutyric acid signaling pathway (GO:0007214)3.32907621
62regulation of neurotransmitter levels (GO:0001505)3.32586810
63neuromuscular process controlling balance (GO:0050885)3.32371321
64postsynaptic membrane organization (GO:0001941)3.31618695
65neuromuscular process controlling posture (GO:0050884)3.30556816
66regulation of postsynaptic membrane potential (GO:0060078)3.29537227
67dendritic spine organization (GO:0097061)3.28171247
68regulation of synaptic plasticity (GO:0048167)3.27849069
69neuromuscular synaptic transmission (GO:0007274)3.23244114
70glycine transport (GO:0015816)3.22886873
71response to auditory stimulus (GO:0010996)3.22080359
72positive regulation of neurotransmitter secretion (GO:0001956)3.21798695
73long-term synaptic potentiation (GO:0060291)3.21469752
74negative regulation of synaptic transmission, GABAergic (GO:0032229)3.21004768
75cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.18944075
76cell communication by electrical coupling (GO:0010644)3.17665997
77regulation of dendritic spine development (GO:0060998)3.17459025
78regulation of vesicle fusion (GO:0031338)3.17065376
79G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.15762405
80regulation of neurotransmitter transport (GO:0051588)3.14833738
81regulation of dendritic spine morphogenesis (GO:0061001)3.14764213
82adult walking behavior (GO:0007628)3.12939735
83regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.12837249
84membrane hyperpolarization (GO:0060081)3.11724931
85positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.11384490
86cellular sodium ion homeostasis (GO:0006883)3.11019813
87regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.10185311
88activation of protein kinase A activity (GO:0034199)3.09995802
89synapse assembly (GO:0007416)3.09812954
90regulation of synaptic transmission, glutamatergic (GO:0051966)3.09369479
91innervation (GO:0060384)3.09143304
92negative regulation of dendrite morphogenesis (GO:0050774)3.04461777
93cerebellar Purkinje cell layer development (GO:0021680)3.03490074
94presynaptic membrane organization (GO:0097090)3.03341233
95L-amino acid import (GO:0043092)3.03281134
96positive regulation of synaptic transmission, GABAergic (GO:0032230)3.02544683
97cell differentiation in hindbrain (GO:0021533)3.02523402
98neuronal ion channel clustering (GO:0045161)3.01130850
99presynaptic membrane assembly (GO:0097105)3.00273115
100regulation of ARF protein signal transduction (GO:0032012)3.00244907
101pyrimidine nucleobase catabolic process (GO:0006208)3.00232154
102membrane depolarization during action potential (GO:0086010)3.00048584
103acidic amino acid transport (GO:0015800)3.00013454
104G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.99006927
105positive regulation of synapse assembly (GO:0051965)2.96386786
106membrane depolarization (GO:0051899)2.95702889
107central nervous system projection neuron axonogenesis (GO:0021952)2.95066604
108mating behavior (GO:0007617)2.95052820
109mechanosensory behavior (GO:0007638)2.91667913
110learning (GO:0007612)2.91554871
111synapse organization (GO:0050808)2.91330610
112establishment of synaptic vesicle localization (GO:0097480)2.91045597
113synaptic vesicle transport (GO:0048489)2.91045597
114prepulse inhibition (GO:0060134)2.91006212
115positive regulation of dendritic spine development (GO:0060999)2.90652873
116synaptic transmission (GO:0007268)2.90477605
117positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.89984952
118potassium ion homeostasis (GO:0055075)2.89784272
119regulation of synapse maturation (GO:0090128)2.89316753
120neuromuscular process (GO:0050905)2.86552725
121negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.85845118
122regulation of synaptic transmission (GO:0050804)2.85162730
123positive regulation of potassium ion transmembrane transport (GO:1901381)2.83183775

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.81873428
2GBX2_23144817_ChIP-Seq_PC3_Human3.18077649
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.15708120
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.12485179
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.10168536
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.86952055
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.86952055
8JARID2_20075857_ChIP-Seq_MESCs_Mouse2.71616446
9* REST_21632747_ChIP-Seq_MESCs_Mouse2.66956648
10EZH2_27304074_Chip-Seq_ESCs_Mouse2.64488459
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.64107496
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.58319849
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.57382633
14DROSHA_22980978_ChIP-Seq_HELA_Human2.56838063
15SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.54589540
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.54531433
17EZH2_27294783_Chip-Seq_ESCs_Mouse2.42281310
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.40849817
19RARB_27405468_Chip-Seq_BRAIN_Mouse2.40188618
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.38103695
21RNF2_27304074_Chip-Seq_ESCs_Mouse2.32758093
22REST_18959480_ChIP-ChIP_MESCs_Mouse2.24425281
23CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.14180844
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.11638137
25NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.10862469
26EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.02872382
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.02328174
28IKZF1_21737484_ChIP-ChIP_HCT116_Human2.01091457
29THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.96858946
30MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.93466722
31AR_21572438_ChIP-Seq_LNCaP_Human1.89367322
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.60962262
33ERG_21242973_ChIP-ChIP_JURKAT_Human1.60857404
34PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.57513085
35SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.49390341
36SMAD4_21799915_ChIP-Seq_A2780_Human1.46223566
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.45694787
38RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.43752380
39RING1B_27294783_Chip-Seq_ESCs_Mouse1.42866340
40CTBP1_25329375_ChIP-Seq_LNCAP_Human1.42618904
41ZNF274_21170338_ChIP-Seq_K562_Hela1.40029953
42TAF15_26573619_Chip-Seq_HEK293_Human1.37298181
43CBX2_27304074_Chip-Seq_ESCs_Mouse1.37119159
44* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.27884809
45RING1B_27294783_Chip-Seq_NPCs_Mouse1.26685503
46SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.25896892
47DNAJC2_21179169_ChIP-ChIP_NT2_Human1.25288109
48NR3C1_23031785_ChIP-Seq_PC12_Mouse1.25202304
49SOX2_21211035_ChIP-Seq_LN229_Gbm1.24617976
50SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23524692
51ZFP281_18757296_ChIP-ChIP_E14_Mouse1.23405745
52ZFP57_27257070_Chip-Seq_ESCs_Mouse1.22607584
53AR_19668381_ChIP-Seq_PC3_Human1.22097122
54WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.21467470
55WT1_25993318_ChIP-Seq_PODOCYTE_Human1.21396282
56BMI1_23680149_ChIP-Seq_NPCS_Mouse1.19383720
57SMAD3_21741376_ChIP-Seq_EPCs_Human1.19083490
58OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18511981
59KDM2B_26808549_Chip-Seq_K562_Human1.17167120
60P300_19829295_ChIP-Seq_ESCs_Human1.16593060
61GATA1_26923725_Chip-Seq_HPCs_Mouse1.13520149
62TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.13258334
63STAT3_23295773_ChIP-Seq_U87_Human1.13133698
64RNF2_27304074_Chip-Seq_NSC_Mouse1.11765761
65P53_22127205_ChIP-Seq_FIBROBLAST_Human1.11426037
66AR_25329375_ChIP-Seq_VCAP_Human1.11145772
67TOP2B_26459242_ChIP-Seq_MCF-7_Human1.07059446
68TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06061975
69PIAS1_25552417_ChIP-Seq_VCAP_Human1.05906634
70TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.05439510
71EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.04512257
72YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02838796
73CDX2_19796622_ChIP-Seq_MESCs_Mouse1.01961102
74IGF1R_20145208_ChIP-Seq_DFB_Human1.01606957
75TRIM28_21343339_ChIP-Seq_HEK293_Human1.00604181
76OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.00290050
77SMAD_19615063_ChIP-ChIP_OVARY_Human0.99457207
78ZNF217_24962896_ChIP-Seq_MCF-7_Human0.99325539
79ARNT_22903824_ChIP-Seq_MCF-7_Human0.97857833
80SMAD3_21741376_ChIP-Seq_ESCs_Human0.97760332
81MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97378692
82TCF4_23295773_ChIP-Seq_U87_Human0.97114850
83VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.96158935
84SMAD4_21741376_ChIP-Seq_HESCs_Human0.96105217
85TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.95216166
86AHR_22903824_ChIP-Seq_MCF-7_Human0.94473028
87ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.93922344
88SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.91124442
89TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91112936
90TP53_20018659_ChIP-ChIP_R1E_Mouse0.90632673
91* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.90279245
92NR3C1_21868756_ChIP-Seq_MCF10A_Human0.90264925
93GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90171443
94AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.89948901
95TET1_21490601_ChIP-Seq_MESCs_Mouse0.89734471
96ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.87590012
97TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86966148
98RUNX2_22187159_ChIP-Seq_PCA_Human0.86691584
99ZFP281_27345836_Chip-Seq_ESCs_Mouse0.86259858
100SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.85347318
101TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84664803
102POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.84664803
103RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.84494022
104PRDM14_20953172_ChIP-Seq_ESCs_Human0.84088837
105EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.83049005
106CTCF_27219007_Chip-Seq_Bcells_Human0.82642589
107* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.81467074
108TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.81311535
109LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80030247
110DPY_21335234_ChIP-Seq_ESCs_Mouse0.78218812
111DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.78211566
112CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.77083597
113SOX9_26525672_Chip-Seq_HEART_Mouse0.76967615
114* OCT4_19829295_ChIP-Seq_ESCs_Human0.76131393
115* PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.76087897
116ISL1_27105846_Chip-Seq_CPCs_Mouse0.75694441
117RUNX1_26923725_Chip-Seq_HPCs_Mouse0.74373858
118* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.73404002
119CTNNB1_20460455_ChIP-Seq_HCT116_Human0.73079956

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.06532738
2MP0003880_abnormal_central_pattern4.32569472
3MP0003635_abnormal_synaptic_transmissio3.95867388
4MP0004270_analgesia3.68711866
5MP0009046_muscle_twitch3.18655778
6MP0002063_abnormal_learning/memory/cond3.10838728
7MP0009745_abnormal_behavioral_response3.09733315
8MP0002064_seizures3.07292698
9MP0005423_abnormal_somatic_nervous2.93135261
10MP0001968_abnormal_touch/_nociception2.87504838
11MP0002734_abnormal_mechanical_nocicepti2.71972825
12MP0002572_abnormal_emotion/affect_behav2.62582855
13MP0002272_abnormal_nervous_system2.61608999
14MP0001486_abnormal_startle_reflex2.53899339
15MP0000778_abnormal_nervous_system2.27383951
16MP0002735_abnormal_chemical_nociception2.22209520
17MP0002736_abnormal_nociception_after2.21528983
18MP0008569_lethality_at_weaning2.12081659
19MP0002733_abnormal_thermal_nociception2.07936784
20MP0002184_abnormal_innervation2.05030123
21MP0002067_abnormal_sensory_capabilities2.01093441
22MP0001440_abnormal_grooming_behavior2.00877253
23MP0001501_abnormal_sleep_pattern1.98152630
24MP0001970_abnormal_pain_threshold1.95819484
25MP0004858_abnormal_nervous_system1.95160713
26MP0003329_amyloid_beta_deposits1.91353463
27MP0006276_abnormal_autonomic_nervous1.84908285
28MP0002822_catalepsy1.82914116
29MP0004811_abnormal_neuron_physiology1.82366217
30MP0002557_abnormal_social/conspecific_i1.79460945
31MP0000955_abnormal_spinal_cord1.79421370
32MP0004885_abnormal_endolymph1.79178891
33MP0009780_abnormal_chondrocyte_physiolo1.73873521
34MP0005386_behavior/neurological_phenoty1.68978165
35MP0004924_abnormal_behavior1.68978165
36MP0003122_maternal_imprinting1.66985291
37MP0002882_abnormal_neuron_morphology1.60453166
38MP0001984_abnormal_olfaction1.54638225
39MP0003123_paternal_imprinting1.49615162
40MP0002066_abnormal_motor_capabilities/c1.48371127
41MP0002909_abnormal_adrenal_gland1.45621570
42MP0005646_abnormal_pituitary_gland1.45165970
43MP0004142_abnormal_muscle_tone1.44927240
44MP0005645_abnormal_hypothalamus_physiol1.41548268
45MP0001502_abnormal_circadian_rhythm1.35336217
46MP0001529_abnormal_vocalization1.34645528
47MP0000920_abnormal_myelination1.30939237
48MP0002152_abnormal_brain_morphology1.28239296
49MP0003633_abnormal_nervous_system1.27836147
50MP0001905_abnormal_dopamine_level1.26335561
51MP0003787_abnormal_imprinting1.25051830
52MP0003879_abnormal_hair_cell1.23706870
53MP0004145_abnormal_muscle_electrophysio1.23081932
54MP0004742_abnormal_vestibular_system1.22796024
55MP0003631_nervous_system_phenotype1.17547465
56MP0003634_abnormal_glial_cell1.15910514
57MP0005551_abnormal_eye_electrophysiolog1.14972962
58MP0002229_neurodegeneration1.11067780
59MP0003632_abnormal_nervous_system1.04940317
60MP0000569_abnormal_digit_pigmentation1.03990910
61MP0005394_taste/olfaction_phenotype1.00443141
62MP0005499_abnormal_olfactory_system1.00443141
63MP0003690_abnormal_glial_cell0.99948964
64MP0001299_abnormal_eye_distance/0.98631476
65MP0002752_abnormal_somatic_nervous0.96405421
66MP0000631_abnormal_neuroendocrine_gland0.93854311
67MP0002069_abnormal_eating/drinking_beha0.92080297
68MP0000751_myopathy0.91491878
69MP0001188_hyperpigmentation0.90263455
70MP0002638_abnormal_pupillary_reflex0.89082379
71MP0005623_abnormal_meninges_morphology0.88768059
72MP0003283_abnormal_digestive_organ0.88020325
73MP0001963_abnormal_hearing_physiology0.86212089
74MP0003861_abnormal_nervous_system0.82394145
75MP0004233_abnormal_muscle_weight0.81242723
76MP0001177_atelectasis0.81213431
77MP0008872_abnormal_physiological_respon0.79231640
78MP0008877_abnormal_DNA_methylation0.78778025
79MP0002653_abnormal_ependyma_morphology0.78383214
80MP0002090_abnormal_vision0.76957202
81MP0003137_abnormal_impulse_conducting0.76129996
82MP0004085_abnormal_heartbeat0.75786711
83MP0003938_abnormal_ear_development0.75556236
84MP0010386_abnormal_urinary_bladder0.74254837
85MP0001485_abnormal_pinna_reflex0.74016860
86MP0000604_amyloidosis0.73536673
87MP0000013_abnormal_adipose_tissue0.73425681
88MP0002249_abnormal_larynx_morphology0.72792741
89MP0006292_abnormal_olfactory_placode0.71216977
90MP0008961_abnormal_basal_metabolism0.71040089
91MP0001986_abnormal_taste_sensitivity0.68842893
92MP0006072_abnormal_retinal_apoptosis0.68715711
93MP0008874_decreased_physiological_sensi0.64988624
94MP0001943_abnormal_respiration0.63898774
95MP0005409_darkened_coat_color0.61436757
96MP0010769_abnormal_survival0.61412869
97MP0005187_abnormal_penis_morphology0.61261791
98MP0000566_synostosis0.60429716
99MP0004147_increased_porphyrin_level0.60059248
100MP0010770_preweaning_lethality0.59406345
101MP0002082_postnatal_lethality0.59406345
102MP0000026_abnormal_inner_ear0.58265300
103MP0000534_abnormal_ureter_morphology0.58263453
104MP0010768_mortality/aging0.57343385
105MP0004215_abnormal_myocardial_fiber0.56948048
106MP0005535_abnormal_body_temperature0.56341554
107MP0001348_abnormal_lacrimal_gland0.55856717
108MP0003121_genomic_imprinting0.54840412
109MP0001346_abnormal_lacrimal_gland0.54803952
110MP0005167_abnormal_blood-brain_barrier0.54435946
111MP0004133_heterotaxia0.54211593
112MP0002081_perinatal_lethality0.53029441
113MP0004130_abnormal_muscle_cell0.51513777

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.27747576
2Focal motor seizures (HP:0011153)6.13195389
3Focal seizures (HP:0007359)5.13668584
4Visual hallucinations (HP:0002367)4.91418688
5Progressive cerebellar ataxia (HP:0002073)4.66926804
6Epileptic encephalopathy (HP:0200134)4.45547797
7Action tremor (HP:0002345)4.35993136
8Supranuclear gaze palsy (HP:0000605)3.92970957
9Atonic seizures (HP:0010819)3.84666913
10Febrile seizures (HP:0002373)3.65601674
11Ankle clonus (HP:0011448)3.64368237
12Absence seizures (HP:0002121)3.58482339
13Broad-based gait (HP:0002136)3.31607056
14Dialeptic seizures (HP:0011146)3.26136435
15Generalized tonic-clonic seizures (HP:0002069)3.23021934
16Gaze-evoked nystagmus (HP:0000640)3.11233488
17Dysmetria (HP:0001310)3.08106662
18Dysdiadochokinesis (HP:0002075)3.07616898
19Mutism (HP:0002300)3.06768274
20Depression (HP:0000716)3.03139971
21Abnormal eating behavior (HP:0100738)3.01995314
22Poor eye contact (HP:0000817)3.00698520
23Neurofibrillary tangles (HP:0002185)2.98621108
24Genetic anticipation (HP:0003743)2.98259546
25Cerebral hypomyelination (HP:0006808)2.95848676
26Abnormality of the corticospinal tract (HP:0002492)2.86259540
27Truncal ataxia (HP:0002078)2.86236604
28Limb dystonia (HP:0002451)2.83049997
29Spastic gait (HP:0002064)2.81824112
30Megalencephaly (HP:0001355)2.77259876
31Scanning speech (HP:0002168)2.75956904
32Urinary bladder sphincter dysfunction (HP:0002839)2.74730242
33Anxiety (HP:0000739)2.74639944
34Impaired vibration sensation in the lower limbs (HP:0002166)2.73879513
35Impaired social interactions (HP:0000735)2.73403983
36Abnormal social behavior (HP:0012433)2.73403983
37Intention tremor (HP:0002080)2.72966270
38Cerebral inclusion bodies (HP:0100314)2.65257330
39Postural instability (HP:0002172)2.64913206
40Hyperventilation (HP:0002883)2.62512449
41Hemiparesis (HP:0001269)2.61708160
42Excessive salivation (HP:0003781)2.56361227
43Drooling (HP:0002307)2.56361227
44Insidious onset (HP:0003587)2.53705039
45Termporal pattern (HP:0011008)2.53705039
46Papilledema (HP:0001085)2.53402465
47Pheochromocytoma (HP:0002666)2.52725364
48Torticollis (HP:0000473)2.50080911
49Urinary urgency (HP:0000012)2.49001318
50Amblyopia (HP:0000646)2.46980033
51Progressive inability to walk (HP:0002505)2.46086594
52Tetraplegia (HP:0002445)2.45239453
53Polyphagia (HP:0002591)2.41675876
54Impaired smooth pursuit (HP:0007772)2.41358908
55Hemiplegia (HP:0002301)2.37831997
56Diplopia (HP:0000651)2.34969198
57Abnormality of binocular vision (HP:0011514)2.34969198
58Focal dystonia (HP:0004373)2.33803996
59Abnormality of the lower motor neuron (HP:0002366)2.30871715
60Epileptiform EEG discharges (HP:0011182)2.28736588
61EEG with generalized epileptiform discharges (HP:0011198)2.27505205
62Stereotypic behavior (HP:0000733)2.26507708
63Delusions (HP:0000746)2.22413572
64Absent speech (HP:0001344)2.19859212
65Lower limb muscle weakness (HP:0007340)2.19813756
66Hypsarrhythmia (HP:0002521)2.19513791
67Abnormality of ocular smooth pursuit (HP:0000617)2.18946191
68Agitation (HP:0000713)2.18101589
69Apathy (HP:0000741)2.14706335
70Amyotrophic lateral sclerosis (HP:0007354)2.14466622
71Insomnia (HP:0100785)2.12462105
72Neuroendocrine neoplasm (HP:0100634)2.10886115
73Bradykinesia (HP:0002067)2.09417874
74Craniofacial dystonia (HP:0012179)2.06363224
75Split foot (HP:0001839)2.05408314
76Peripheral hypomyelination (HP:0007182)2.02744032
77Turricephaly (HP:0000262)2.02264349
78Fetal akinesia sequence (HP:0001989)1.98693127
79Spastic tetraparesis (HP:0001285)1.98217060
80Specific learning disability (HP:0001328)1.97799075
81Degeneration of the lateral corticospinal tracts (HP:0002314)1.97487523
82Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.97487523
83Dysmetric saccades (HP:0000641)1.97431900
84Clonus (HP:0002169)1.97356345
85Pointed chin (HP:0000307)1.97172799
86Ventricular fibrillation (HP:0001663)1.97021473
87Diminished motivation (HP:0000745)1.95488878
88Morphological abnormality of the pyramidal tract (HP:0002062)1.95236979
89Failure to thrive in infancy (HP:0001531)1.94546346
90Obstructive sleep apnea (HP:0002870)1.94495613
91Sleep apnea (HP:0010535)1.93293920
92Akinesia (HP:0002304)1.93247158
93Generalized myoclonic seizures (HP:0002123)1.92418637
94Bronchomalacia (HP:0002780)1.89708522
95CNS hypomyelination (HP:0003429)1.89420244
96Gait ataxia (HP:0002066)1.88567447
97Aplasia involving bones of the upper limbs (HP:0009823)1.88021898
98Aplasia of the phalanges of the hand (HP:0009802)1.88021898
99Aplasia involving bones of the extremities (HP:0009825)1.88021898
100Aqueductal stenosis (HP:0002410)1.87912438
101Spinal canal stenosis (HP:0003416)1.86793687
102Status epilepticus (HP:0002133)1.85666328
103Spastic tetraplegia (HP:0002510)1.85345699
104Neuronal loss in central nervous system (HP:0002529)1.83093063
105Annular pancreas (HP:0001734)1.82447726
106Hypoventilation (HP:0002791)1.81790715
107Incomplete penetrance (HP:0003829)1.79133685
108Inability to walk (HP:0002540)1.79102808
109Choreoathetosis (HP:0001266)1.78725702
110Abnormality of saccadic eye movements (HP:0000570)1.78289607
111Postural tremor (HP:0002174)1.77928099
112Rigidity (HP:0002063)1.77873926
113Aplasia/Hypoplasia of the brainstem (HP:0007362)1.77149216
114Hypoplasia of the brainstem (HP:0002365)1.77149216
115Retinal dysplasia (HP:0007973)1.76480892
116Hand muscle atrophy (HP:0009130)1.76393587
117Rapidly progressive (HP:0003678)1.76239231
118Impaired vibratory sensation (HP:0002495)1.76209627
119Lower limb asymmetry (HP:0100559)1.76189466
120Neoplasm of the heart (HP:0100544)1.74497271
121Hypoplasia of the corpus callosum (HP:0002079)1.73826346
122Mild short stature (HP:0003502)1.71320744

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK13.79082961
2NTRK33.76261279
3MAP3K93.72006843
4EPHA42.87582393
5MAP3K42.87195882
6MINK12.79734219
7PAK62.73009064
8NTRK22.39256925
9MAP2K72.23042380
10DAPK22.11516510
11PRKD31.88180602
12CDK191.86100483
13NTRK11.82380073
14KSR21.79575003
15MAP2K41.71637184
16UHMK11.71599517
17KSR11.71209511
18CAMKK11.71200622
19MAP3K121.64641960
20PRPF4B1.62436474
21CDK51.56430171
22TYRO31.53481891
23CASK1.47780834
24MAPK131.44469947
25PNCK1.42183510
26TNIK1.39404599
27PHKG11.38420627
28PHKG21.38420627
29PLK21.29769708
30CAMKK21.27526247
31OXSR11.26870317
32GRK51.22090560
33SGK4941.19744531
34SGK2231.19744531
35CDK181.18383894
36PRKCG1.16532762
37STK381.15534373
38LATS21.15490104
39CDK151.14992627
40CDK141.14531007
41CDK11A1.02061910
42PAK31.01913483
43DAPK10.99811406
44WNK10.92544451
45SIK20.92409478
46CAMK2A0.92318286
47FGFR20.91566188
48CSNK1G20.90850334
49ARAF0.89511482
50PRKCH0.88958771
51MAP3K20.88896429
52STK110.87376919
53CAMK10.86931350
54RET0.86768960
55BCR0.86757826
56STK390.85971572
57DYRK1A0.84924993
58LMTK20.84786609
59CAMK2B0.84195654
60FES0.83433350
61RIPK40.82067158
62MARK20.78004056
63LIMK10.77734499
64PINK10.73607262
65CAMK1G0.71191756
66SGK20.68785762
67ICK0.68470560
68ALK0.68381637
69ROCK20.67987787
70PKN10.67831378
71SIK30.66556770
72NEK60.64910122
73BRSK10.64385754
74SGK30.62717364
75TAOK10.62109675
76RIPK10.61217910
77MAPKAPK50.61154537
78SGK10.58964731
79TESK10.58897177
80BRAF0.57584315
81CAMK2D0.56977993
82CAMK2G0.55435731
83CDC42BPA0.54566043
84PRKCZ0.54110649
85MAPK120.53828152
86DYRK20.53512439
87MAP3K130.53254294
88DAPK30.51527035
89CSNK1G30.51130003
90FYN0.50673410
91PRKCE0.48759538
92WNK30.48613845
93PTK2B0.47557692
94PDPK10.47532368
95RPS6KA30.47289086
96MAPK100.45717603
97PDK10.45461365
98ROCK10.42643897
99CAMK40.42394800
100ERBB20.42367507
101FER0.42192536
102CSNK1A1L0.41634275
103PDGFRA0.41604762
104NEK10.41227838
105MAP3K110.40086687
106RPS6KA20.39797640
107MAP3K10.37987410
108RAF10.37783659
109DYRK1B0.37612812
110DMPK0.37077882
111EPHB20.37051989
112WNK40.30552360
113PAK20.30258690
114PRKG10.30182020
115MAPK80.29942340
116PRKCA0.29688750
117DDR20.29579933
118SRC0.27856785

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.58070452
2Synaptic vesicle cycle_Homo sapiens_hsa047213.42086066
3GABAergic synapse_Homo sapiens_hsa047272.76682909
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.61224249
5Circadian entrainment_Homo sapiens_hsa047132.59483628
6Glutamatergic synapse_Homo sapiens_hsa047242.58767202
7Olfactory transduction_Homo sapiens_hsa047402.40667472
8Morphine addiction_Homo sapiens_hsa050322.40314221
9Long-term potentiation_Homo sapiens_hsa047202.37223280
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.28625440
11Amphetamine addiction_Homo sapiens_hsa050312.14526988
12Dopaminergic synapse_Homo sapiens_hsa047282.12388062
13Salivary secretion_Homo sapiens_hsa049702.04319450
14Insulin secretion_Homo sapiens_hsa049111.94194048
15Cholinergic synapse_Homo sapiens_hsa047251.90627900
16Long-term depression_Homo sapiens_hsa047301.83003097
17Gastric acid secretion_Homo sapiens_hsa049711.78820110
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.72218638
19Serotonergic synapse_Homo sapiens_hsa047261.67872240
20Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.66168682
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.65316990
22Taste transduction_Homo sapiens_hsa047421.65065431
23Cocaine addiction_Homo sapiens_hsa050301.59128252
24Oxytocin signaling pathway_Homo sapiens_hsa049211.54791167
25Renin secretion_Homo sapiens_hsa049241.50241229
26Axon guidance_Homo sapiens_hsa043601.49491744
27Gap junction_Homo sapiens_hsa045401.42512289
28Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.42407274
29GnRH signaling pathway_Homo sapiens_hsa049121.36762499
30Calcium signaling pathway_Homo sapiens_hsa040201.35310108
31Collecting duct acid secretion_Homo sapiens_hsa049661.33966119
32Nitrogen metabolism_Homo sapiens_hsa009101.33437595
33Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.24747834
34Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.23833007
35cAMP signaling pathway_Homo sapiens_hsa040241.20132943
36Type II diabetes mellitus_Homo sapiens_hsa049301.17255175
37Vitamin B6 metabolism_Homo sapiens_hsa007501.14501576
38Estrogen signaling pathway_Homo sapiens_hsa049151.12321821
39Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.09683951
40Phosphatidylinositol signaling system_Homo sapiens_hsa040701.09240663
41ErbB signaling pathway_Homo sapiens_hsa040121.08966487
42Melanogenesis_Homo sapiens_hsa049161.08682884
43Glioma_Homo sapiens_hsa052141.07712190
44Cardiac muscle contraction_Homo sapiens_hsa042600.98114180
45cGMP-PKG signaling pathway_Homo sapiens_hsa040220.96663695
46Vibrio cholerae infection_Homo sapiens_hsa051100.95248840
47Phospholipase D signaling pathway_Homo sapiens_hsa040720.92189744
48Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.91386991
49Phototransduction_Homo sapiens_hsa047440.88693791
50Oocyte meiosis_Homo sapiens_hsa041140.88113195
51Vascular smooth muscle contraction_Homo sapiens_hsa042700.86782514
52Dorso-ventral axis formation_Homo sapiens_hsa043200.85184279
53Pancreatic secretion_Homo sapiens_hsa049720.80962273
54Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.78648964
55Choline metabolism in cancer_Homo sapiens_hsa052310.76567770
56Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.75990282
57Thyroid hormone synthesis_Homo sapiens_hsa049180.75424723
58Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.74946048
59MAPK signaling pathway_Homo sapiens_hsa040100.72443731
60Dilated cardiomyopathy_Homo sapiens_hsa054140.70810992
61Neurotrophin signaling pathway_Homo sapiens_hsa047220.69212525
62Renal cell carcinoma_Homo sapiens_hsa052110.65590496
63Endocytosis_Homo sapiens_hsa041440.64634222
64Sphingolipid signaling pathway_Homo sapiens_hsa040710.64284156
65Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.63858892
66Carbohydrate digestion and absorption_Homo sapiens_hsa049730.63074423
67Ras signaling pathway_Homo sapiens_hsa040140.62558277
68Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.61859372
69Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.61536728
70Wnt signaling pathway_Homo sapiens_hsa043100.61520700
71VEGF signaling pathway_Homo sapiens_hsa043700.60697177
72Thyroid hormone signaling pathway_Homo sapiens_hsa049190.59579937
73Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.58267163
74Endometrial cancer_Homo sapiens_hsa052130.57065793
75Alcoholism_Homo sapiens_hsa050340.56631737
76Rap1 signaling pathway_Homo sapiens_hsa040150.54900279
77Hedgehog signaling pathway_Homo sapiens_hsa043400.54699723
78Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.51994608
79mTOR signaling pathway_Homo sapiens_hsa041500.51265515
80SNARE interactions in vesicular transport_Homo sapiens_hsa041300.50327764
81Inositol phosphate metabolism_Homo sapiens_hsa005620.49796047
82Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.49393544
83Circadian rhythm_Homo sapiens_hsa047100.44313218
84Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.44200386
85Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.43975786
86Colorectal cancer_Homo sapiens_hsa052100.43040671
87Bile secretion_Homo sapiens_hsa049760.42742264
88Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.41739438
89Prion diseases_Homo sapiens_hsa050200.40689262
90Glucagon signaling pathway_Homo sapiens_hsa049220.40316629
91Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.40222018
92Longevity regulating pathway - mammal_Homo sapiens_hsa042110.39462358
93Non-small cell lung cancer_Homo sapiens_hsa052230.39397896
94Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.38785496
95Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.38030985
96Arginine and proline metabolism_Homo sapiens_hsa003300.35513595
97AMPK signaling pathway_Homo sapiens_hsa041520.35258615
98Ovarian steroidogenesis_Homo sapiens_hsa049130.35233469
99Hippo signaling pathway_Homo sapiens_hsa043900.35133900
100Insulin signaling pathway_Homo sapiens_hsa049100.34557535
101Tight junction_Homo sapiens_hsa045300.34036827
102Protein digestion and absorption_Homo sapiens_hsa049740.32292190
103Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.31658975
104Alzheimers disease_Homo sapiens_hsa050100.31387285
105Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.31324664
106Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.31281783
107Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.28025717
108Basal cell carcinoma_Homo sapiens_hsa052170.27452221
109Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.26057001

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »