CLIP4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)5.44533629
2negative regulation of potassium ion transmembrane transporter activity (GO:1901017)5.23326831
3positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.07521899
4plasma membrane repair (GO:0001778)4.88435177
5sarcomere organization (GO:0045214)4.87632672
6negative regulation of potassium ion transmembrane transport (GO:1901380)4.73824669
7regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.64060770
8cardiac myofibril assembly (GO:0055003)4.58541936
9regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.55123058
10regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.40599798
11cell communication involved in cardiac conduction (GO:0086065)4.31264566
12regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.29616691
13bundle of His cell to Purkinje myocyte communication (GO:0086069)4.29551083
14ventricular cardiac muscle cell action potential (GO:0086005)4.27479430
15hemidesmosome assembly (GO:0031581)4.26106027
16cardiac muscle contraction (GO:0060048)4.25724190
17myofibril assembly (GO:0030239)4.19733318
18actin-myosin filament sliding (GO:0033275)4.13967821
19muscle filament sliding (GO:0030049)4.13967821
20regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.13530828
21sarcoplasmic reticulum calcium ion transport (GO:0070296)4.07473168
22cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.93301692
23regulation of skeletal muscle contraction (GO:0014819)3.91645050
24regulation of membrane repolarization (GO:0060306)3.89212447
25membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.83817061
26regulation of tight junction assembly (GO:2000810)3.68164362
27regulation of cell communication by electrical coupling (GO:0010649)3.66590503
28detection of calcium ion (GO:0005513)3.61591698
29tricarboxylic acid cycle (GO:0006099)3.60813211
30striated muscle contraction (GO:0006941)3.60198704
31cell communication by electrical coupling (GO:0010644)3.54394100
32cardiac conduction (GO:0061337)3.53445176
33hypotonic response (GO:0006971)3.52282466
34regulation of heart rate by cardiac conduction (GO:0086091)3.51143454
35regulation of actin filament-based movement (GO:1903115)3.50623342
36positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.44677779
37acrosome reaction (GO:0007340)3.44301371
38cardiac muscle cell action potential involved in contraction (GO:0086002)3.43158748
39actin-mediated cell contraction (GO:0070252)3.42629808
40cardiac muscle cell action potential (GO:0086001)3.40471241
41regulation of relaxation of muscle (GO:1901077)3.38978313
42cardiac muscle cell development (GO:0055013)3.28060720
43regulation of calcium ion transmembrane transporter activity (GO:1901019)3.26634984
44regulation of calcium ion transmembrane transport (GO:1903169)3.26634984
45positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.26437732
46sperm motility (GO:0030317)3.25954719
47macroautophagy (GO:0016236)3.22918945
48membrane depolarization during action potential (GO:0086010)3.19659969
49actomyosin structure organization (GO:0031032)3.19206412
50regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.18069818
51regulation of synapse structural plasticity (GO:0051823)3.13885899
52regulation of acyl-CoA biosynthetic process (GO:0050812)3.13285481
53membrane raft organization (GO:0031579)3.11823194
54regulation of striated muscle contraction (GO:0006942)3.11566966
55regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.10587982
56toxin transport (GO:1901998)3.09764912
57positive regulation of potassium ion transmembrane transport (GO:1901381)3.09258578
58cardiac muscle hypertrophy (GO:0003300)3.07440568
59cardiac cell development (GO:0055006)3.07347139
60regulation of type B pancreatic cell apoptotic process (GO:2000674)3.03272973
61adult heart development (GO:0007512)3.01601528
62negative regulation of cytosolic calcium ion concentration (GO:0051481)3.01196021
63striated muscle hypertrophy (GO:0014897)2.99488955
64barbed-end actin filament capping (GO:0051016)2.98176831
65regulation of heart rate (GO:0002027)2.98137737
66carnitine shuttle (GO:0006853)2.97325209
67negative regulation of inclusion body assembly (GO:0090084)2.96609799
68cardiac muscle tissue morphogenesis (GO:0055008)2.94971179
69epithelial cilium movement (GO:0003351)2.94486449
70regulation of the force of heart contraction (GO:0002026)2.92364383
71cell adhesion mediated by integrin (GO:0033627)2.91854275
72negative regulation of potassium ion transport (GO:0043267)2.87895225
73regulation of necroptotic process (GO:0060544)2.87678276
74relaxation of cardiac muscle (GO:0055119)2.87445604
75regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.87144671
76regulation of sarcomere organization (GO:0060297)2.83760315
77ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.82028266
78regulation of potassium ion transmembrane transport (GO:1901379)2.81991797
79regulation of cofactor metabolic process (GO:0051193)2.80910044
80regulation of coenzyme metabolic process (GO:0051196)2.80910044
81heart trabecula formation (GO:0060347)2.80620728
82fusion of sperm to egg plasma membrane (GO:0007342)2.79982932
83axonemal dynein complex assembly (GO:0070286)2.79734582
84potassium ion import (GO:0010107)2.78784889
85positive regulation of cation channel activity (GO:2001259)2.78412569
86cilium movement (GO:0003341)2.78243830
87carnitine transmembrane transport (GO:1902603)2.77812704
88negative regulation of necroptotic process (GO:0060546)2.77459453
89regulation of potassium ion transmembrane transporter activity (GO:1901016)2.76473082
90negative regulation of sodium ion transport (GO:0010766)2.75521464
91positive regulation of potassium ion transport (GO:0043268)2.75417736
92vocalization behavior (GO:0071625)2.75196431
93regulation of heart contraction (GO:0008016)2.74471158
94negative regulation of ion transmembrane transporter activity (GO:0032413)2.74413116
95mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.73492001
96regulation of cation channel activity (GO:2001257)2.73283854
97regulation of cardiac muscle contraction (GO:0055117)2.71994399
98neuronal action potential propagation (GO:0019227)2.71987037
99muscle tissue morphogenesis (GO:0060415)2.70860861
100response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.70759877
101growth hormone receptor signaling pathway (GO:0060396)2.70194525
102calcium ion-dependent exocytosis (GO:0017156)2.69719926
103membrane repolarization (GO:0086009)2.69441576
104multicellular organismal signaling (GO:0035637)2.68715891
105antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.66934712
106regulation of short-term neuronal synaptic plasticity (GO:0048172)2.65620998
107neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.64610230
108striatum development (GO:0021756)2.64219125
109response to inactivity (GO:0014854)2.64050294
110motile cilium assembly (GO:0044458)2.62970909
111negative regulation of protein localization to cell surface (GO:2000009)2.61761391
112calcium-mediated signaling using intracellular calcium source (GO:0035584)2.61218249
113carnitine transport (GO:0015879)2.60888558
114amino-acid betaine transport (GO:0015838)2.60888558
115activation of protein kinase A activity (GO:0034199)2.60637014
116positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.57383962
117establishment of skin barrier (GO:0061436)2.55572878
118positive regulation of receptor recycling (GO:0001921)2.50975485
119cellular response to thyroid hormone stimulus (GO:0097067)2.48596216
120retrograde transport, vesicle recycling within Golgi (GO:0000301)2.44707543
121regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.44684792
122cell-substrate junction assembly (GO:0007044)2.39510711
123signal complex assembly (GO:0007172)2.37588021
124keratinocyte development (GO:0003334)2.37247150
125skin morphogenesis (GO:0043589)2.37003257
126regulation of necrotic cell death (GO:0010939)2.34896036
127protein localization to endosome (GO:0036010)2.34813830
128negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.34114051
129smooth muscle tissue development (GO:0048745)2.33527463
130regulation of water loss via skin (GO:0033561)2.30071966
131cellular response to growth hormone stimulus (GO:0071378)2.29758638
132protein targeting to Golgi (GO:0000042)2.29215920
133interleukin-6-mediated signaling pathway (GO:0070102)2.28068402
134regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.27987175
135negative regulation of systemic arterial blood pressure (GO:0003085)2.27113166
136Golgi to endosome transport (GO:0006895)2.25700475
137phospholipid translocation (GO:0045332)2.25111179
138lipid translocation (GO:0034204)2.25111179
139establishment of protein localization to Golgi (GO:0072600)2.18938682
140negative regulation of necrotic cell death (GO:0060547)2.17441954
141keratinocyte proliferation (GO:0043616)2.15249158
142cellular response to arsenic-containing substance (GO:0071243)2.15166034
143estrogen biosynthetic process (GO:0006703)2.14007510
144syncytium formation by plasma membrane fusion (GO:0000768)2.08466376
145apoptotic cell clearance (GO:0043277)2.07434319
146regulation of transforming growth factor beta1 production (GO:0032908)2.06339384
147actin filament-based movement (GO:0030048)2.05944844
148positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.05677363
149Golgi to plasma membrane protein transport (GO:0043001)2.05269076
150platelet-derived growth factor receptor signaling pathway (GO:0048008)2.04701251
151early endosome to late endosome transport (GO:0045022)2.03266832
152protein localization to cell surface (GO:0034394)2.01546929
153protein hydroxylation (GO:0018126)2.00711002
154regulation of receptor recycling (GO:0001919)2.00358538
155vesicle transport along microtubule (GO:0047496)2.00002774
156endodermal cell differentiation (GO:0035987)1.97281272
157negative regulation of nitric oxide biosynthetic process (GO:0045019)1.95022615
158myoblast fusion (GO:0007520)1.94820968
159negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)1.92884862
160negative regulation of protein localization to plasma membrane (GO:1903077)1.92245116
161peptide cross-linking (GO:0018149)1.92077668
162cellular response to vitamin (GO:0071295)1.86655763
163oligosaccharide catabolic process (GO:0009313)1.86613287
164regulation of ARF protein signal transduction (GO:0032012)1.84758019
165plasma membrane fusion (GO:0045026)1.84598295
166positive regulation of phosphoprotein phosphatase activity (GO:0032516)1.83837412
167regulation of skeletal muscle cell differentiation (GO:2001014)1.83226607
168keratinization (GO:0031424)1.83152288
169heterotypic cell-cell adhesion (GO:0034113)1.82882048
170import into cell (GO:0098657)1.82774939
171positive regulation of T cell chemotaxis (GO:0010820)1.82114796
172regulation of T cell chemotaxis (GO:0010819)1.82114796
173negative regulation of macrophage derived foam cell differentiation (GO:0010745)1.81136549
174skeletal muscle tissue regeneration (GO:0043403)1.81066353
175positive regulation of myoblast differentiation (GO:0045663)1.81010826
176antigen processing and presentation of endogenous peptide antigen (GO:0002483)1.81004418
177antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)1.80954187
178negative regulation of establishment of protein localization to plasma membrane (GO:0090005)1.79996151
179Golgi to plasma membrane transport (GO:0006893)1.79237431
180keratan sulfate catabolic process (GO:0042340)1.79102515

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.19371528
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.55647282
3SMAD_19615063_ChIP-ChIP_OVARY_Human2.88655699
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.40563363
5Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.21633314
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.15470032
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.13473917
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.12647680
9EP300_21415370_ChIP-Seq_HL-1_Mouse2.06017487
10* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.96371550
11EZH2_27304074_Chip-Seq_ESCs_Mouse1.95585104
12JARID2_20064375_ChIP-Seq_MESCs_Mouse1.95431597
13GATA2_21666600_ChIP-Seq_HMVEC_Human1.95014515
14SUZ12_27294783_Chip-Seq_ESCs_Mouse1.94488750
15* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.93734457
16STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.93064295
17GATA1_22025678_ChIP-Seq_K562_Human1.92689587
18RNF2_18974828_ChIP-Seq_MESCs_Mouse1.92482384
19EZH2_18974828_ChIP-Seq_MESCs_Mouse1.92482384
20EZH2_27294783_Chip-Seq_ESCs_Mouse1.92165459
21SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.91595398
22JARID2_20075857_ChIP-Seq_MESCs_Mouse1.82925434
23DROSHA_22980978_ChIP-Seq_HELA_Human1.82454611
24CJUN_26792858_Chip-Seq_BT549_Human1.82096946
25TP63_17297297_ChIP-ChIP_HaCaT_Human1.81804548
26BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.78145147
27SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.77701088
28GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.75663090
29NRF2_20460467_ChIP-Seq_MEFs_Mouse1.72500040
30NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.72500040
31GBX2_23144817_ChIP-Seq_PC3_Human1.71610106
32SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.68795079
33RNF2_27304074_Chip-Seq_ESCs_Mouse1.68435235
34TRIM28_21343339_ChIP-Seq_HEK293_Human1.68317425
35SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.67143610
36CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.65333606
37STAT6_21828071_ChIP-Seq_BEAS2B_Human1.63271711
38PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.63031777
39SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.62482480
40SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.62482480
41RUNX_20019798_ChIP-Seq_JUKART_Human1.62050568
42VDR_22108803_ChIP-Seq_LS180_Human1.62038509
43ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.61971206
44RARB_27405468_Chip-Seq_BRAIN_Mouse1.61565955
45REST_21632747_ChIP-Seq_MESCs_Mouse1.58552318
46NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.52052415
47EED_16625203_ChIP-ChIP_MESCs_Mouse1.50661672
48ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.49585392
49CDX2_19796622_ChIP-Seq_MESCs_Mouse1.45956038
50TP53_16413492_ChIP-PET_HCT116_Human1.45081994
51* BRD4_25478319_ChIP-Seq_HGPS_Human1.44674342
52FOXO3_23340844_ChIP-Seq_DLD1_Human1.44378577
53TAF15_26573619_Chip-Seq_HEK293_Human1.43876892
54TP63_23658742_ChIP-Seq_EP156T_Human1.43767515
55RARG_19884340_ChIP-ChIP_MEFs_Mouse1.40699054
56VDR_24787735_ChIP-Seq_THP-1_Human1.40076218
57IRF8_22096565_ChIP-ChIP_GC-B_Human1.39813958
58ZNF274_21170338_ChIP-Seq_K562_Hela1.39730440
59SMAD4_21799915_ChIP-Seq_A2780_Human1.38105855
60CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.36825933
61STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.36082284
62TBX20_22080862_ChIP-Seq_HEART_Mouse1.34570861
63TBX20_22328084_ChIP-Seq_HEART_Mouse1.34570861
64PPAR_26484153_Chip-Seq_NCI-H1993_Human1.32983029
65* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.32647645
66MYB_21317192_ChIP-Seq_ERMYB_Mouse1.32143954
67ESR1_20079471_ChIP-ChIP_T-47D_Human1.31487761
68CTBP2_25329375_ChIP-Seq_LNCAP_Human1.28044527
69* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.27892940
70BCAT_22108803_ChIP-Seq_LS180_Human1.27350292
71CBX2_27304074_Chip-Seq_ESCs_Mouse1.26943846
72AR_21572438_ChIP-Seq_LNCaP_Human1.26845731
73TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.26768846
74AHR_22903824_ChIP-Seq_MCF-7_Human1.26591083
75CTBP1_25329375_ChIP-Seq_LNCAP_Human1.25555740
76ZNF263_19887448_ChIP-Seq_K562_Human1.24457059
77REST_18959480_ChIP-ChIP_MESCs_Mouse1.21533681
78SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.21428944
79IRF8_27001747_Chip-Seq_BMDM_Mouse1.20536969
80CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.20461723
81BP1_19119308_ChIP-ChIP_Hs578T_Human1.20122355
82ZNF217_24962896_ChIP-Seq_MCF-7_Human1.19820365
83NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.19136273
84PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.18819858
85ARNT_22903824_ChIP-Seq_MCF-7_Human1.18261419
86SOX9_24532713_ChIP-Seq_HFSC_Mouse1.18136863
87* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17867117
88CTNNB1_20460455_ChIP-Seq_HCT116_Human1.17838008
89MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.17221985
90CTCF_27219007_Chip-Seq_Bcells_Human1.16624288
91* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.15558324
92CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.15168489
93CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.12338143
94RING1B_27294783_Chip-Seq_ESCs_Mouse1.11756096
95P63_26484246_Chip-Seq_KERATINOCYTES_Human1.09320427
96TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.08356137
97PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.07566770
98PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06639735
99WT1_25993318_ChIP-Seq_PODOCYTE_Human1.06219427
100* SMAD3_21741376_ChIP-Seq_EPCs_Human1.06121089
101SOX2_21211035_ChIP-Seq_LN229_Gbm1.04559858
102SOX2_20726797_ChIP-Seq_SW620_Human1.04171063
103IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.03805079
104ESR2_21235772_ChIP-Seq_MCF-7_Human1.03638337
105GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.03579614
106* SMAD3_21741376_ChIP-Seq_HESCs_Human1.03144408
107NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.01672613
108SALL4_18804426_ChIP-ChIP_XEN_Mouse1.01551844
109ZFP57_27257070_Chip-Seq_ESCs_Mouse1.01379769
110CLOCK_20551151_ChIP-Seq_293T_Human1.00941816
111NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.00073497
112PIAS1_25552417_ChIP-Seq_VCAP_Human0.99964788
113AR_25329375_ChIP-Seq_VCAP_Human0.99089841
114NR3C1_23031785_ChIP-Seq_PC12_Mouse0.96387007
115FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.95839529
116* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.95222711
117POU3F2_20337985_ChIP-ChIP_501MEL_Human0.95154348
118EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.93256889
119TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.92751406
120* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.91842797
121TP53_18474530_ChIP-ChIP_U2OS_Human0.91696822
122* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.91310614
123ERG_21242973_ChIP-ChIP_JURKAT_Human0.91149218
124* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.91144058
125TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90626242
126RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90407933
127IKZF1_21737484_ChIP-ChIP_HCT116_Human0.90387333
128* SMAD4_21741376_ChIP-Seq_HESCs_Human0.90082907
129RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.89251990
130ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.89163371
131PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.89156523
132RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.88663948
133TCF4_18268006_ChIP-ChIP_LS174T_Human0.88612988
134ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.88451777
135SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.87828291
136NFIB_24661679_ChIP-Seq_LUNG_Mouse0.87717601
137PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.87637674
138P300_19829295_ChIP-Seq_ESCs_Human0.87389334
139* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.86852359
140BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.86679424
141TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.86448748
142SMAD4_21741376_ChIP-Seq_EPCs_Human0.85977178
143AR_19668381_ChIP-Seq_PC3_Human0.84880536
144TP63_22573176_ChIP-Seq_HFKS_Human0.84798943
145BMI1_23680149_ChIP-Seq_NPCS_Mouse0.84410132
146ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.84346486
147* SMAD3_21741376_ChIP-Seq_ESCs_Human0.84080382
148NANOG_18555785_Chip-Seq_ESCs_Mouse0.83896044
149AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.83020172
150IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.82238259
151CBP_20019798_ChIP-Seq_JUKART_Human0.82238259
152TCF4_23295773_ChIP-Seq_U87_Human0.81893764
153PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.80649096
154TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.80315545
155STAT3_23295773_ChIP-Seq_U87_Human0.80187277
156CDX2_22108803_ChIP-Seq_LS180_Human0.79859483
157RNF2_27304074_Chip-Seq_NSC_Mouse0.79650140
158RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.79547527
159VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.79198298
160SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.78873817
161KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.78822529
162TBL1_22424771_ChIP-Seq_293T_Human0.78367050
163TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.77860503
164RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.77585026

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis4.94443495
2MP0003646_muscle_fatigue4.75123395
3MP0000751_myopathy4.40767413
4MP0004084_abnormal_cardiac_muscle3.62583108
5MP0004215_abnormal_myocardial_fiber3.48124205
6MP0004036_abnormal_muscle_relaxation3.27290610
7MP0000749_muscle_degeneration2.97668013
8MP0008438_abnormal_cutaneous_collagen2.81371379
9MP0005410_abnormal_fertilization2.80205080
10MP0004859_abnormal_synaptic_plasticity2.75873454
11MP0004145_abnormal_muscle_electrophysio2.48821299
12MP0005330_cardiomyopathy2.48812686
13MP0003880_abnormal_central_pattern2.35195082
14MP0002796_impaired_skin_barrier2.32222494
15MP0003191_abnormal_cellular_cholesterol2.29975432
16MP0002822_catalepsy2.20606267
17MP0004087_abnormal_muscle_fiber2.19654046
18MP0005620_abnormal_muscle_contractility2.17302666
19MP0003690_abnormal_glial_cell2.14165988
20MP0002972_abnormal_cardiac_muscle2.11539177
21MP0002877_abnormal_melanocyte_morpholog2.09526468
22MP0003137_abnormal_impulse_conducting2.08160518
23MP0004484_altered_response_of2.04860200
24MP0001958_emphysema1.93048083
25MP0002106_abnormal_muscle_physiology1.92196120
26MP0003635_abnormal_synaptic_transmissio1.85590969
27MP0004130_abnormal_muscle_cell1.85058194
28MP0006082_CNS_inflammation1.84554764
29MP0004270_analgesia1.83770580
30MP0004085_abnormal_heartbeat1.82680090
31MP0008775_abnormal_heart_ventricle1.79640551
32MP0000750_abnormal_muscle_regeneration1.75771715
33MP0003091_abnormal_cell_migration1.71418145
34MP0006138_congestive_heart_failure1.69677574
35MP0003279_aneurysm1.68347894
36MP0004233_abnormal_muscle_weight1.65011390
37MP0000747_muscle_weakness1.64908667
38MP0005164_abnormal_response_to1.64712464
39MP0005023_abnormal_wound_healing1.64425899
40MP0002269_muscular_atrophy1.62290029
41MP0003300_gastrointestinal_ulcer1.61986988
42MP0000465_gastrointestinal_hemorrhage1.61512697
43MP0003566_abnormal_cell_adhesion1.60685583
44MP0005369_muscle_phenotype1.60516920
45MP0005385_cardiovascular_system_phenoty1.59407857
46MP0001544_abnormal_cardiovascular_syste1.59407857
47MP0009745_abnormal_behavioral_response1.59304920
48MP0002234_abnormal_pharynx_morphology1.58069770
49MP0009046_muscle_twitch1.57270358
50MP0000759_abnormal_skeletal_muscle1.54711413
51MP0005275_abnormal_skin_tensile1.54550739
52MP0002998_abnormal_bone_remodeling1.54036867
53MP0000733_abnormal_muscle_development1.52900470
54MP0001984_abnormal_olfaction1.50711269
55MP0003045_fibrosis1.50674780
56MP0000003_abnormal_adipose_tissue1.50622360
57MP0002063_abnormal_learning/memory/cond1.47682003
58MP0003941_abnormal_skin_development1.47637703
59MP0001542_abnormal_bone_strength1.47329335
60MP0010234_abnormal_vibrissa_follicle1.47230315
61MP0009840_abnormal_foam_cell1.44204909
62MP0004272_abnormal_basement_membrane1.44120863
63MP0010630_abnormal_cardiac_muscle1.42926403
64MP0001348_abnormal_lacrimal_gland1.42749639
65MP0000569_abnormal_digit_pigmentation1.41904438
66MP0010386_abnormal_urinary_bladder1.40711661
67MP0003453_abnormal_keratinocyte_physiol1.38690413
68MP0002971_abnormal_brown_adipose1.38075039
69MP0002909_abnormal_adrenal_gland1.34122792
70MP0002064_seizures1.32715050
71MP0001968_abnormal_touch/_nociception1.31909917
72MP0002060_abnormal_skin_morphology1.28201150
73MP0002272_abnormal_nervous_system1.25869999
74MP0005058_abnormal_lysosome_morphology1.25827639
75MP0000579_abnormal_nail_morphology1.24905507
76MP0005623_abnormal_meninges_morphology1.23010333
77MP0001440_abnormal_grooming_behavior1.22109779
78MP0002572_abnormal_emotion/affect_behav1.21025913
79MP0003075_altered_response_to1.20142385
80MP0003705_abnormal_hypodermis_morpholog1.18402088
81MP0004858_abnormal_nervous_system1.18132292
82MP0000604_amyloidosis1.17470355
83MP0005503_abnormal_tendon_morphology1.14786498
84MP0000920_abnormal_myelination1.14028014
85MP0004947_skin_inflammation1.13987644
86MP0002332_abnormal_exercise_endurance1.13853204
87MP0002896_abnormal_bone_mineralization1.13126991
88MP0010368_abnormal_lymphatic_system1.11258512
89MP0000681_abnormal_thyroid_gland1.10684900
90MP0005166_decreased_susceptibility_to1.09908012
91MP0003828_pulmonary_edema1.07769792
92MP0001486_abnormal_startle_reflex1.07540631
93MP0002876_abnormal_thyroid_physiology1.07230172
94MP0002736_abnormal_nociception_after1.06326718
95MP0004883_abnormal_blood_vessel1.05945524
96MP0008569_lethality_at_weaning1.05714597
97MP0003950_abnormal_plasma_membrane1.04521481
98MP0002735_abnormal_chemical_nociception1.04274925
99MP0001661_extended_life_span1.03746376
100MP0004510_myositis1.02693792
101MP0002734_abnormal_mechanical_nocicepti1.01850204
102MP0005501_abnormal_skin_physiology1.00402902
103MP0000383_abnormal_hair_follicle1.00338091
104MP0003329_amyloid_beta_deposits1.00152092
105MP0000343_altered_response_to0.99578683
106MP0000685_abnormal_immune_system0.98285530
107MP0001851_eye_inflammation0.97744510
108MP0009780_abnormal_chondrocyte_physiolo0.97374358
109MP0000013_abnormal_adipose_tissue0.95972177
110MP0001501_abnormal_sleep_pattern0.93424870
111MP0008961_abnormal_basal_metabolism0.92834822
112MP0010352_gastrointestinal_tract_polyps0.90723534
113MP0005666_abnormal_adipose_tissue0.90559591
114MP0002067_abnormal_sensory_capabilities0.89801378
115MP0003724_increased_susceptibility_to0.89291710
116MP0003698_abnormal_male_reproductive0.88830952
117MP0001533_abnormal_skeleton_physiology0.87928937
118MP0003172_abnormal_lysosome_physiology0.86950453
119MP0005386_behavior/neurological_phenoty0.86899896
120MP0004924_abnormal_behavior0.86899896
121MP0002419_abnormal_innate_immunity0.86572731
122MP0002108_abnormal_muscle_morphology0.85877782
123MP0005670_abnormal_white_adipose0.85297953
124MP0004185_abnormal_adipocyte_glucose0.85284829
125MP0003448_altered_tumor_morphology0.84099109
126MP0006036_abnormal_mitochondrial_physio0.83553736
127MP0005595_abnormal_vascular_smooth0.83321066
128MP0002184_abnormal_innervation0.83225897
129MP0002127_abnormal_cardiovascular_syste0.82429010
130MP0001970_abnormal_pain_threshold0.82280941
131MP0005409_darkened_coat_color0.82249152
132MP0005423_abnormal_somatic_nervous0.81103703
133MP0002166_altered_tumor_susceptibility0.79974844
134MP0001216_abnormal_epidermal_layer0.78234798
135MP0001529_abnormal_vocalization0.76511655
136MP0002733_abnormal_thermal_nociception0.76276252
137MP0003436_decreased_susceptibility_to0.75359018
138MP0005165_increased_susceptibility_to0.74829228
139MP0010771_integument_phenotype0.74081728
140MP0005187_abnormal_penis_morphology0.74076019
141MP0006276_abnormal_autonomic_nervous0.72913965
142MP0002557_abnormal_social/conspecific_i0.71707618
143MP0005375_adipose_tissue_phenotype0.71158975
144MP0003795_abnormal_bone_structure0.70964584
145MP0003221_abnormal_cardiomyocyte_apopto0.70332129
146MP0005379_endocrine/exocrine_gland_phen0.69974466
147MP0006035_abnormal_mitochondrial_morpho0.65802266
148MP0003879_abnormal_hair_cell0.64960945
149MP0005451_abnormal_body_composition0.62903817
150MP0010678_abnormal_skin_adnexa0.62864515
151MP0002066_abnormal_motor_capabilities/c0.61979040
152MP0000230_abnormal_systemic_arterial0.61607870
153MP0004811_abnormal_neuron_physiology0.60785374
154MP0002882_abnormal_neuron_morphology0.60449902
155MP0001765_abnormal_ion_homeostasis0.58804356
156MP0004043_abnormal_pH_regulation0.58738840
157MP0002254_reproductive_system_inflammat0.58513157

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)6.27702539
2Exercise-induced myalgia (HP:0003738)5.78516485
3Calf muscle hypertrophy (HP:0008981)5.43199735
4Muscle hypertrophy of the lower extremities (HP:0008968)5.17962035
5Ventricular tachycardia (HP:0004756)5.00564218
6Hyporeflexia of lower limbs (HP:0002600)4.89852699
7Exercise-induced muscle cramps (HP:0003710)4.76494591
8Right ventricular cardiomyopathy (HP:0011663)4.67856976
9Abnormality of the calf musculature (HP:0001430)4.45811806
10Atrial fibrillation (HP:0005110)4.45389729
11Ventricular fibrillation (HP:0001663)4.27523849
12Primary atrial arrhythmia (HP:0001692)4.23778903
13Muscle fiber splitting (HP:0003555)4.22256408
14Syncope (HP:0001279)4.10492362
15Supraventricular tachycardia (HP:0004755)4.02617610
16Absent/shortened dynein arms (HP:0200106)3.99389020
17Dynein arm defect of respiratory motile cilia (HP:0012255)3.99389020
18Bundle branch block (HP:0011710)3.95150697
19Supraventricular arrhythmia (HP:0005115)3.92441226
20Myoglobinuria (HP:0002913)3.75589288
21Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.66900925
22Difficulty running (HP:0009046)3.62547279
23Prolonged QT interval (HP:0001657)3.54023414
24EMG: myopathic abnormalities (HP:0003458)3.33346763
25Abnormality of glycolipid metabolism (HP:0010969)3.33057454
26Abnormality of liposaccharide metabolism (HP:0010968)3.33057454
27Abnormality of glycosphingolipid metabolism (HP:0004343)3.33057454
28Ventricular arrhythmia (HP:0004308)3.29370128
29Abnormality of the left ventricular outflow tract (HP:0011103)3.16608585
30Subaortic stenosis (HP:0001682)3.16608585
31Lipoatrophy (HP:0100578)3.15947522
32Alopecia of scalp (HP:0002293)3.09691558
33Heart block (HP:0012722)3.09630388
34Myotonia (HP:0002486)3.04792169
35Focal motor seizures (HP:0011153)3.03301393
36Atrophic scars (HP:0001075)3.01840696
37Palpitations (HP:0001962)3.01708147
38Abnormal atrioventricular conduction (HP:0005150)3.00245868
39Increased connective tissue (HP:0009025)3.00005410
40Abnormal respiratory motile cilium physiology (HP:0012261)2.98456132
41Thoracolumbar scoliosis (HP:0002944)2.97484655
42Arterial tortuosity (HP:0005116)2.94229247
43Neurofibrillary tangles (HP:0002185)2.92552582
44Muscle fiber inclusion bodies (HP:0100299)2.91124480
45Vascular tortuosity (HP:0004948)2.91013004
46Asymmetric septal hypertrophy (HP:0001670)2.89060910
47Spondylolisthesis (HP:0003302)2.88507577
48Abnormal EKG (HP:0003115)2.78729784
49Atrioventricular block (HP:0001678)2.78514302
50Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.76637830
51Dilated cardiomyopathy (HP:0001644)2.73189272
52Difficulty climbing stairs (HP:0003551)2.68238136
53Increased variability in muscle fiber diameter (HP:0003557)2.67659747
54Osteolytic defects of the hand bones (HP:0009699)2.64876875
55Osteolytic defects of the phalanges of the hand (HP:0009771)2.64876875
56Type 1 muscle fiber predominance (HP:0003803)2.63507577
57Aortic aneurysm (HP:0004942)2.63243618
58Increased CSF protein (HP:0002922)2.62352233
59Abnormal respiratory epithelium morphology (HP:0012253)2.60791537
60Abnormal respiratory motile cilium morphology (HP:0005938)2.60791537
61Myokymia (HP:0002411)2.58936555
62Tetraparesis (HP:0002273)2.57406903
63Protrusio acetabuli (HP:0003179)2.54929192
64Abnormal ciliary motility (HP:0012262)2.54359462
65Distal lower limb muscle weakness (HP:0009053)2.48161862
66Areflexia of lower limbs (HP:0002522)2.45407161
67Aortic dissection (HP:0002647)2.45224078
68Abnormality of skeletal muscle fiber size (HP:0012084)2.39888467
69Palmoplantar keratoderma (HP:0000982)2.39807161
70Left ventricular hypertrophy (HP:0001712)2.39613464
71Muscle stiffness (HP:0003552)2.39588302
72Dysmetric saccades (HP:0000641)2.38565401
73Onycholysis (HP:0001806)2.35978694
74Vertebral compression fractures (HP:0002953)2.35823608
75Striae distensae (HP:0001065)2.35415576
76Rhabdomyolysis (HP:0003201)2.34033897
77Congenital malformation of the right heart (HP:0011723)2.32804218
78Double outlet right ventricle (HP:0001719)2.32804218
79Milia (HP:0001056)2.32591097
80Conjunctival hamartoma (HP:0100780)2.32314984
81Nemaline bodies (HP:0003798)2.29059415
82Cerebral inclusion bodies (HP:0100314)2.28300476
83Mitral stenosis (HP:0001718)2.25797189
84Distal lower limb amyotrophy (HP:0008944)2.23035009
85Rhinitis (HP:0012384)2.19821212
86Abnormality of macular pigmentation (HP:0008002)2.16780543
87Thick nail (HP:0001805)2.15825475
88EMG: neuropathic changes (HP:0003445)2.15567403
89Lower limb amyotrophy (HP:0007210)2.12380565
90Acute necrotizing encephalopathy (HP:0006965)2.11196867
91Wormian bones (HP:0002645)2.10088306
92Abnormal mitochondria in muscle tissue (HP:0008316)2.09292401
93Fatigue (HP:0012378)2.09275227
94Neck muscle weakness (HP:0000467)2.08895154
95Premature rupture of membranes (HP:0001788)2.05240070
96Testicular atrophy (HP:0000029)2.05096013
97Ulnar deviation of the wrist (HP:0003049)2.03910315
98Central scotoma (HP:0000603)2.03520755
99Spinal cord lesions (HP:0100561)2.03204093
100Syringomyelia (HP:0003396)2.03204093
101Chronic bronchitis (HP:0004469)2.03125766
102Foot dorsiflexor weakness (HP:0009027)2.01815592
103Abnormality of the foot musculature (HP:0001436)2.01266697
104Focal seizures (HP:0007359)1.99981877
105Hypotrichosis (HP:0001006)1.97153519
106Rapidly progressive (HP:0003678)1.96992683
107Centrally nucleated skeletal muscle fibers (HP:0003687)1.96788415
108Glucose intolerance (HP:0000833)1.96609223
109Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.96163797
110Frequent falls (HP:0002359)1.93481020
111Absent frontal sinuses (HP:0002688)1.91899458
112Round ear (HP:0100830)1.91666479
113Hamartoma of the eye (HP:0010568)1.91211897
114Limb-girdle muscle atrophy (HP:0003797)1.90895138
115Eczematoid dermatitis (HP:0000976)1.90797416
116Progressive macrocephaly (HP:0004481)1.90556615
117Interstitial pulmonary disease (HP:0006530)1.90031667
118Peritonitis (HP:0002586)1.88990656
119Abnormality of the columella (HP:0009929)1.86682743
120Spinal rigidity (HP:0003306)1.86503095
121Palmoplantar hyperkeratosis (HP:0000972)1.86464894
122Infertility (HP:0000789)1.85515011
123Pheochromocytoma (HP:0002666)1.85204233
124Supranuclear gaze palsy (HP:0000605)1.85079635
125Visual hallucinations (HP:0002367)1.84494456
126Mildly elevated creatine phosphokinase (HP:0008180)1.84080314
127Dysostosis multiplex (HP:0000943)1.83752879
128Urinary glycosaminoglycan excretion (HP:0003541)1.83256971
129Mucopolysacchariduria (HP:0008155)1.83256971
130Dysdiadochokinesis (HP:0002075)1.80420101
131Abnormality of the neuromuscular junction (HP:0003398)1.79711415
132Fatigable weakness (HP:0003473)1.79711415
133Cone-rod dystrophy (HP:0000548)1.79057349
134Distal arthrogryposis (HP:0005684)1.78685854
135Abnormality of polysaccharide metabolism (HP:0011012)1.77775179
136Abnormality of glycosaminoglycan metabolism (HP:0004371)1.77775179
137Abnormality of mucopolysaccharide metabolism (HP:0011020)1.77775179
138Rimmed vacuoles (HP:0003805)1.76822609
139Gowers sign (HP:0003391)1.76307718
140Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.75956965
141Craniofacial hyperostosis (HP:0004493)1.74450622
142Papillary thyroid carcinoma (HP:0002895)1.74439572
143Hypoplasia of dental enamel (HP:0006297)1.73592754
144Hyperkalemia (HP:0002153)1.72409436
145Metaphyseal dysplasia (HP:0100255)1.72266491
146Cubitus valgus (HP:0002967)1.71761234
147Nuclear cataract (HP:0100018)1.71576446
148Fragile skin (HP:0001030)1.71496850
149Muscular dystrophy (HP:0003560)1.71306360
150Sudden cardiac death (HP:0001645)1.69448220
151Palmar hyperkeratosis (HP:0010765)1.69076804
152Bradycardia (HP:0001662)1.68751335
153Progressive cerebellar ataxia (HP:0002073)1.67876480
154Plantar hyperkeratosis (HP:0007556)1.67779768
155Abnormality of the vocal cords (HP:0008777)1.67676620
156Myocardial infarction (HP:0001658)1.67304495
157Proximal amyotrophy (HP:0007126)1.67300845
158Steppage gait (HP:0003376)1.66941950
159Cranial hyperostosis (HP:0004437)1.66049271
160Atonic seizures (HP:0010819)1.66039798
161Loss of speech (HP:0002371)1.65632777
162Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.64944614
163Bulbar palsy (HP:0001283)1.64898085
164Menstrual irregularities (HP:0000858)1.63915712
165Dilatation of the ascending aorta (HP:0005111)1.63599804
166Acanthosis nigricans (HP:0000956)1.60278342

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK44.25726253
2PDK34.25726253
3PHKG13.35668782
4PHKG23.35668782
5TTN3.28210426
6EPHA43.17501404
7OBSCN3.10796795
8LMTK22.86566723
9PRKD32.85982408
10PDK22.53172523
11TGFBR22.32470773
12MUSK2.15121757
13PINK12.04815945
14NTRK31.99183826
15DMPK1.93422566
16MAP3K131.83903825
17EPHB11.76755287
18STK381.72304705
19MET1.65062422
20NEK91.62933989
21MAP3K91.61930970
22MOS1.61193577
23FRK1.48862457
24BMPR21.48314232
25MAP3K31.47329433
26MYLK1.46944254
27PIK3CG1.40622858
28MAP3K41.38459238
29TAOK31.36282785
30GRK71.33549425
31PTK2B1.32987937
32JAK11.32211926
33WNK41.30368593
34PDGFRA1.30115618
35MAPK71.28595434
36NTRK21.27397975
37MAPKAPK31.23284075
38KSR21.23179766
39TRIB31.22881202
40MAP3K61.22401441
41FER1.22009965
42MAP2K41.20396927
43ICK1.18824077
44MAP3K141.15511932
45STK241.15227844
46ZAP701.13546288
47PAK31.13450536
48ERN11.13130309
49AKT31.11004223
50TESK11.10914790
51PTK21.10839647
52DDR21.08695362
53MINK11.08470876
54PRPF4B1.07848464
55MAP2K31.07439029
56NME11.05959368
57GRK51.02434738
58CAMK2A1.02083979
59RIPK41.01162758
60NEK11.00098921
61CAMK2D0.99913555
62PAK60.98720265
63LATS20.97199497
64DAPK20.96747833
65MAP3K70.94137499
66STK390.93323771
67PDGFRB0.92875027
68CAMKK10.91241168
69IRAK30.90536080
70TAOK10.90202586
71PNCK0.89366618
72TBK10.88217697
73WNK10.87205793
74LIMK10.85533093
75NLK0.85412511
76MAP3K20.84455233
77PRKD10.84252512
78HIPK20.82961009
79MARK10.82539290
80RPS6KA20.81028471
81PKN20.76796039
82ROCK10.76512200
83PIK3CA0.76221156
84EPHB20.75222807
85CDK50.74282784
86KIT0.73679625
87EPHA30.73008956
88JAK30.72536788
89EPHA20.71507089
90DAPK30.70880601
91NTRK10.70204173
92MAP2K70.69934417
93TYRO30.69719664
94CAMK10.69070585
95CASK0.68315303
96PRKG20.68039153
97MAPK120.67634914
98FGFR30.67624588
99IRAK40.65823989
100TYK20.65729689
101ABL20.64692426
102MAP3K10.63963087
103PDK10.63645016
104STK110.62894725
105PDPK10.62815048
106DAPK10.62786511
107FLT30.62334311
108ERBB30.62174354
109TRPM70.60318405
110PRKCE0.60102017
111CAMKK20.59201288
112CDC42BPA0.58508889
113TIE10.57516597
114STK38L0.57269265
115RET0.56689340
116CSK0.56567960
117ERBB40.56346061
118ROCK20.54359060
119JAK20.53790478
120PRKACA0.52361596
121BCR0.52244964
122MAPK100.50902497
123CAMK2G0.50805828
124SGK10.50461013
125PKN10.50376109
126RPS6KL10.50195821
127RPS6KC10.50195821
128PRKCG0.49367257
129KSR10.48577928
130PRKAA10.48401995
131TNIK0.47901761
132IRAK20.46856807
133RIPK10.46163462
134CAMK40.46130589
135MARK30.45013601
136TXK0.43816172
137MAP2K60.42819742
138STK30.42721094
139MAP3K50.41963353
140MARK20.41549390
141MAP2K10.41410391
142SGK20.41404580
143MST1R0.41121434
144CAMK2B0.40340381
145ILK0.40281064
146ARAF0.38979185
147MAP3K120.38301058
148CAMK1G0.38211232
149SGK2230.38132303
150SGK4940.38132303
151PRKACG0.37677295
152LATS10.37631442
153PLK20.36542624
154SGK30.36318597
155PRKAA20.36315987

Predicted pathways (KEGG)

RankGene SetZ-score
1Cardiac muscle contraction_Homo sapiens_hsa042603.28579138
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.91169210
3Dilated cardiomyopathy_Homo sapiens_hsa054142.43751703
4Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.21155030
5Olfactory transduction_Homo sapiens_hsa047402.15060871
6Oxidative phosphorylation_Homo sapiens_hsa001902.12933092
7Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042612.06844456
8Parkinsons disease_Homo sapiens_hsa050122.00297322
9Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.89119144
10Nicotine addiction_Homo sapiens_hsa050331.86948269
11Circadian entrainment_Homo sapiens_hsa047131.85821605
12Alzheimers disease_Homo sapiens_hsa050101.81483560
13Amphetamine addiction_Homo sapiens_hsa050311.76040295
14Long-term potentiation_Homo sapiens_hsa047201.75051325
15Renin secretion_Homo sapiens_hsa049241.74148297
16Calcium signaling pathway_Homo sapiens_hsa040201.71196289
17Gastric acid secretion_Homo sapiens_hsa049711.70193026
18Salivary secretion_Homo sapiens_hsa049701.62345148
19Propanoate metabolism_Homo sapiens_hsa006401.60939705
20Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.58893992
21Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.57813958
22Oxytocin signaling pathway_Homo sapiens_hsa049211.54937798
23Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.53834626
24Glutamatergic synapse_Homo sapiens_hsa047241.53296972
25Focal adhesion_Homo sapiens_hsa045101.52031513
262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.51299260
27Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.50834278
28Synaptic vesicle cycle_Homo sapiens_hsa047211.50321502
29Lysosome_Homo sapiens_hsa041421.48956991
30Insulin secretion_Homo sapiens_hsa049111.47512232
31ECM-receptor interaction_Homo sapiens_hsa045121.44952643
32Taste transduction_Homo sapiens_hsa047421.44097214
33GABAergic synapse_Homo sapiens_hsa047271.43948480
34Huntingtons disease_Homo sapiens_hsa050161.43089191
35Morphine addiction_Homo sapiens_hsa050321.40306417
36cGMP-PKG signaling pathway_Homo sapiens_hsa040221.35917814
37Dopaminergic synapse_Homo sapiens_hsa047281.35497101
38Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.33941160
39Glucagon signaling pathway_Homo sapiens_hsa049221.33687192
40Aldosterone synthesis and secretion_Homo sapiens_hsa049251.27796380
41Fatty acid biosynthesis_Homo sapiens_hsa000611.25067605
42Other glycan degradation_Homo sapiens_hsa005111.23232519
43Cholinergic synapse_Homo sapiens_hsa047251.20777292
44Glycosaminoglycan degradation_Homo sapiens_hsa005311.20636303
45cAMP signaling pathway_Homo sapiens_hsa040241.16718333
46Vascular smooth muscle contraction_Homo sapiens_hsa042701.16713833
47Fatty acid degradation_Homo sapiens_hsa000711.13566796
48GnRH signaling pathway_Homo sapiens_hsa049121.12532049
49AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.12256549
50Pyruvate metabolism_Homo sapiens_hsa006201.08900426
51Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.08457621
52Amoebiasis_Homo sapiens_hsa051461.07701828
53Osteoclast differentiation_Homo sapiens_hsa043801.05916532
54Cocaine addiction_Homo sapiens_hsa050301.05839660
55Dorso-ventral axis formation_Homo sapiens_hsa043201.05132458
56Proteoglycans in cancer_Homo sapiens_hsa052051.04161668
57Toxoplasmosis_Homo sapiens_hsa051451.03506051
58Serotonergic synapse_Homo sapiens_hsa047261.03165862
59Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.03087495
60Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.01990022
61Fatty acid metabolism_Homo sapiens_hsa012121.00478886
62Collecting duct acid secretion_Homo sapiens_hsa049661.00012188
63TNF signaling pathway_Homo sapiens_hsa046680.99512746
64Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.97669304
65Toll-like receptor signaling pathway_Homo sapiens_hsa046200.94489679
66Regulation of actin cytoskeleton_Homo sapiens_hsa048100.93085530
67Malaria_Homo sapiens_hsa051440.92372619
68Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.91859335
69Carbon metabolism_Homo sapiens_hsa012000.91734968
70mTOR signaling pathway_Homo sapiens_hsa041500.91512131
71Melanogenesis_Homo sapiens_hsa049160.89064723
72Phototransduction_Homo sapiens_hsa047440.88839440
73Platelet activation_Homo sapiens_hsa046110.87244915
74Estrogen signaling pathway_Homo sapiens_hsa049150.86819053
75Gap junction_Homo sapiens_hsa045400.86338461
76Acute myeloid leukemia_Homo sapiens_hsa052210.85924438
77Pancreatic secretion_Homo sapiens_hsa049720.85343035
78NF-kappa B signaling pathway_Homo sapiens_hsa040640.85183301
79Long-term depression_Homo sapiens_hsa047300.84453813
80Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.83735167
81Adherens junction_Homo sapiens_hsa045200.83707112
82Phagosome_Homo sapiens_hsa041450.83644495
83Sphingolipid metabolism_Homo sapiens_hsa006000.82400574
84Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.80998968
85Endocytosis_Homo sapiens_hsa041440.80981248
86Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.79782214
87Sphingolipid signaling pathway_Homo sapiens_hsa040710.78862662
88Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.78697559
89Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.78251082
90Type II diabetes mellitus_Homo sapiens_hsa049300.77959898
91Phosphatidylinositol signaling system_Homo sapiens_hsa040700.77693212
92Axon guidance_Homo sapiens_hsa043600.77273557
93Tuberculosis_Homo sapiens_hsa051520.76586034
94Prolactin signaling pathway_Homo sapiens_hsa049170.75224043
95Jak-STAT signaling pathway_Homo sapiens_hsa046300.75195158
96Neurotrophin signaling pathway_Homo sapiens_hsa047220.74795847
97Leukocyte transendothelial migration_Homo sapiens_hsa046700.74283914
98Insulin signaling pathway_Homo sapiens_hsa049100.74268778
99Adipocytokine signaling pathway_Homo sapiens_hsa049200.72788790
100NOD-like receptor signaling pathway_Homo sapiens_hsa046210.72742042
101Pancreatic cancer_Homo sapiens_hsa052120.72293573
102Salmonella infection_Homo sapiens_hsa051320.70691337
103Pertussis_Homo sapiens_hsa051330.70505086
104Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.70348836
105VEGF signaling pathway_Homo sapiens_hsa043700.70086013
106Fatty acid elongation_Homo sapiens_hsa000620.69875984
107Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.69546528
108Tight junction_Homo sapiens_hsa045300.69371429
109Renal cell carcinoma_Homo sapiens_hsa052110.69312410
110Thyroid hormone signaling pathway_Homo sapiens_hsa049190.68933087
111Small cell lung cancer_Homo sapiens_hsa052220.68362203
112Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.67549499
113FoxO signaling pathway_Homo sapiens_hsa040680.66927133
114T cell receptor signaling pathway_Homo sapiens_hsa046600.65768157
115Measles_Homo sapiens_hsa051620.64800469
116RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.64126088
117Pentose phosphate pathway_Homo sapiens_hsa000300.62284759
118Circadian rhythm_Homo sapiens_hsa047100.61803852
119Leishmaniasis_Homo sapiens_hsa051400.61426431
120Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.61166957
121Thyroid cancer_Homo sapiens_hsa052160.60615875
122Chronic myeloid leukemia_Homo sapiens_hsa052200.60454062
123Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.58346892
124Rheumatoid arthritis_Homo sapiens_hsa053230.57637124
125alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.57455222
126Choline metabolism in cancer_Homo sapiens_hsa052310.55176127
127Butanoate metabolism_Homo sapiens_hsa006500.54963931
128Insulin resistance_Homo sapiens_hsa049310.54870419
129Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.54865454
130PI3K-Akt signaling pathway_Homo sapiens_hsa041510.53900250
131Linoleic acid metabolism_Homo sapiens_hsa005910.53273259
132Oocyte meiosis_Homo sapiens_hsa041140.50703919
133Thyroid hormone synthesis_Homo sapiens_hsa049180.49582409
134PPAR signaling pathway_Homo sapiens_hsa033200.48870612
135Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.48637941
136Carbohydrate digestion and absorption_Homo sapiens_hsa049730.48128974
137MAPK signaling pathway_Homo sapiens_hsa040100.46787289
138AMPK signaling pathway_Homo sapiens_hsa041520.46418336
139Ovarian steroidogenesis_Homo sapiens_hsa049130.45888391
140Phospholipase D signaling pathway_Homo sapiens_hsa040720.44800422
141Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.44721801
142Glioma_Homo sapiens_hsa052140.43249995
143Glycerophospholipid metabolism_Homo sapiens_hsa005640.43027234
144Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.42598809
145Vibrio cholerae infection_Homo sapiens_hsa051100.41757622
146Ras signaling pathway_Homo sapiens_hsa040140.41183815
147ErbB signaling pathway_Homo sapiens_hsa040120.40504997
148Longevity regulating pathway - mammal_Homo sapiens_hsa042110.39720650
149Rap1 signaling pathway_Homo sapiens_hsa040150.39411978
150Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.39356796
151Viral myocarditis_Homo sapiens_hsa054160.37679511
152Central carbon metabolism in cancer_Homo sapiens_hsa052300.37076915
153Mineral absorption_Homo sapiens_hsa049780.36773509
154Inositol phosphate metabolism_Homo sapiens_hsa005620.35428057
155Ether lipid metabolism_Homo sapiens_hsa005650.34209217

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