CLK1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the CDC2-like (or LAMMER) family of dual specificity protein kinases. In the nucleus, the encoded protein phosphorylates serine/arginine-rich proteins involved in pre-mRNA processing, releasing them into the nucleoplasm. The choice of splice sites during pre-mRNA processing may be regulated by the concentration of transacting factors, including serine/arginine rich proteins. Therefore, the encoded protein may play an indirect role in governing splice site selection. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1definitive hemopoiesis (GO:0060216)6.57168934
2daunorubicin metabolic process (GO:0044597)6.05361727
3polyketide metabolic process (GO:0030638)6.05361727
4doxorubicin metabolic process (GO:0044598)6.05361727
5megakaryocyte development (GO:0035855)4.70333469
6negative regulation of cell killing (GO:0031342)4.13072403
7negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.13072403
8positive T cell selection (GO:0043368)4.01540358
9negative T cell selection (GO:0043383)3.97588103
10negative thymic T cell selection (GO:0045060)3.89535221
11interferon-gamma production (GO:0032609)3.86090130
12cell differentiation involved in metanephros development (GO:0072202)3.85560110
13activated T cell proliferation (GO:0050798)3.77158134
14histone H3-K4 trimethylation (GO:0080182)3.76918382
15tolerance induction (GO:0002507)3.66807890
16antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.63767897
17aminoglycoside antibiotic metabolic process (GO:0030647)3.63012396
18cellular response to interleukin-15 (GO:0071350)3.57104956
19poly(A)+ mRNA export from nucleus (GO:0016973)3.56272219
20rRNA methylation (GO:0031167)3.50577311
21RNA destabilization (GO:0050779)3.49123376
22regulation of gamma-delta T cell differentiation (GO:0045586)3.48518675
23positive thymic T cell selection (GO:0045059)3.42257635
24positive regulation of gamma-delta T cell activation (GO:0046645)3.38273586
25response to interleukin-15 (GO:0070672)3.35657138
26negative regulation of phagocytosis (GO:0050765)3.34685721
27regulation of nuclear cell cycle DNA replication (GO:0033262)3.21434139
28T cell selection (GO:0045058)3.16695661
29glomerulus development (GO:0032835)3.15917125
30regulation of alpha-beta T cell proliferation (GO:0046640)3.15697181
31positive regulation of granulocyte differentiation (GO:0030854)3.13299537
32G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.09531576
33negative regulation of T-helper cell differentiation (GO:0045623)3.08049730
34negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.08049730
35mRNA splice site selection (GO:0006376)3.07096921
36mesenchymal cell differentiation involved in renal system development (GO:2001012)3.06934823
37mesenchymal cell differentiation involved in kidney development (GO:0072161)3.06934823
38positive regulation of mRNA catabolic process (GO:0061014)3.01074890
39dendritic cell chemotaxis (GO:0002407)3.00394338
40regulation of T cell tolerance induction (GO:0002664)3.00016258
41negative regulation of lymphocyte mediated immunity (GO:0002707)2.99780912
42antigen processing and presentation of endogenous antigen (GO:0019883)2.98474790
43positive regulation of B cell differentiation (GO:0045579)2.97364944
44positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.97161756
45regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.97161756
46regulation of tolerance induction (GO:0002643)2.96848809
47regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.95730581
48dentate gyrus development (GO:0021542)2.91172436
49negative regulation of T cell mediated immunity (GO:0002710)2.90558623
50energy homeostasis (GO:0097009)2.90401541
51interkinetic nuclear migration (GO:0022027)2.87327943
52negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.86487063
53regulation of B cell differentiation (GO:0045577)2.84900222
54T cell migration (GO:0072678)2.83054744
55microglial cell activation (GO:0001774)2.82080846
56regulation of cell proliferation involved in kidney development (GO:1901722)2.80867049
57negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.80660323
58response to muramyl dipeptide (GO:0032495)2.80116271
59antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.78041302
60positive regulation of cellular amide metabolic process (GO:0034250)2.77906660
61negative regulation of cAMP-mediated signaling (GO:0043951)2.76255929
62negative regulation of adaptive immune response (GO:0002820)2.76180193
63regulation of isotype switching to IgG isotypes (GO:0048302)2.75937883
64negative regulation of alpha-beta T cell activation (GO:0046636)2.75841001
65negative regulation of B cell proliferation (GO:0030889)2.75560516
66negative regulation of immunoglobulin mediated immune response (GO:0002890)2.74796115
67negative regulation of B cell mediated immunity (GO:0002713)2.74796115
68regulation of regulatory T cell differentiation (GO:0045589)2.74085497
69androgen biosynthetic process (GO:0006702)2.73928468
70negative regulation of keratinocyte proliferation (GO:0010839)2.73447369
71establishment of protein localization to Golgi (GO:0072600)2.73237555
72B cell receptor signaling pathway (GO:0050853)2.72601246
73monoubiquitinated protein deubiquitination (GO:0035520)2.71021662
74antigen receptor-mediated signaling pathway (GO:0050851)2.70155228
75dendritic cell migration (GO:0036336)2.68817779
76positive regulation of mRNA metabolic process (GO:1903313)2.67384785
77alpha-beta T cell activation (GO:0046631)2.66932583
78thymic T cell selection (GO:0045061)2.66765354
79histone H3-K36 demethylation (GO:0070544)2.66559731
80CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.66337261
81cellular response to antibiotic (GO:0071236)2.66307298
82natural killer cell activation involved in immune response (GO:0002323)2.65906157
83histone H3-K9 modification (GO:0061647)2.65070943
84cell proliferation involved in kidney development (GO:0072111)2.64825739
85neutrophil activation (GO:0042119)2.63831806
86negative regulation of B cell activation (GO:0050869)2.60668461
87positive regulation of alpha-beta T cell proliferation (GO:0046641)2.60643869
88DNA dealkylation (GO:0035510)2.60502527
89cellular extravasation (GO:0045123)2.60015980
90neutrophil mediated immunity (GO:0002446)2.59906392
91T cell receptor signaling pathway (GO:0050852)2.59661868
92rRNA modification (GO:0000154)2.57641001
93lymph node development (GO:0048535)2.57414020
94histone H3-K4 methylation (GO:0051568)2.57308713
95regulation of mRNA catabolic process (GO:0061013)2.56614706
96relaxation of cardiac muscle (GO:0055119)2.56187047
97protein targeting to Golgi (GO:0000042)2.56114067
98positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.54791566
99regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.54791566
100embryonic hemopoiesis (GO:0035162)2.54546922
101negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.54107093
102nucleotide-binding oligomerization domain containing signaling pathway (GO:0070423)2.53741024
103T-helper cell differentiation (GO:0042093)2.53591255
104CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.53591255
105protein K11-linked deubiquitination (GO:0035871)2.53196582
106myeloid leukocyte mediated immunity (GO:0002444)2.50726261
107antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.50722589
108embryonic camera-type eye morphogenesis (GO:0048596)2.48986742
109positive regulation of T cell mediated cytotoxicity (GO:0001916)2.48948989
110positive regulation of keratinocyte differentiation (GO:0045618)2.48856798
111mast cell activation (GO:0045576)2.48468305
112interferon-gamma-mediated signaling pathway (GO:0060333)2.48405177
113positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.48381141
114CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.48218721
115germinal center formation (GO:0002467)2.47110470
116positive regulation of tolerance induction (GO:0002645)2.47077835
117regulation of germinal center formation (GO:0002634)2.46668722
118negative regulation of mast cell activation (GO:0033004)2.46434499
119negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.45966195
120negative regulation of translation, ncRNA-mediated (GO:0040033)2.45966195
121regulation of translation, ncRNA-mediated (GO:0045974)2.45966195
122negative regulation of alpha-beta T cell differentiation (GO:0046639)2.44396728
123interleukin-1-mediated signaling pathway (GO:0070498)2.44171250
124immunoglobulin mediated immune response (GO:0016064)2.44031911
125positive regulation of defense response to virus by host (GO:0002230)2.43656600
126phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.42971480
127leukocyte aggregation (GO:0070486)2.42174590
128T cell differentiation (GO:0030217)2.41268695
129replication fork processing (GO:0031297)2.40846642
130regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.40812962
131positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.40698469
132regulation of alpha-beta T cell activation (GO:0046634)2.40601265
133regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.39712081
134regulation of fibroblast apoptotic process (GO:2000269)2.39671999
135positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.39330470
136regulation of T cell receptor signaling pathway (GO:0050856)2.39206428
137lymphoid progenitor cell differentiation (GO:0002320)2.38402855
138regulation of mast cell activation (GO:0033003)2.38378384
139angiogenesis involved in wound healing (GO:0060055)2.38336610
140positive regulation of mRNA processing (GO:0050685)2.38117649
141phospholipid scrambling (GO:0017121)2.37873639
142negative regulation of leukocyte mediated immunity (GO:0002704)2.36832512
143positive regulation of interleukin-1 beta secretion (GO:0050718)2.36770756
144regulation of memory T cell differentiation (GO:0043380)2.34794321
145T cell lineage commitment (GO:0002360)2.33374747
146B cell differentiation (GO:0030183)2.31162643
147cytoplasmic pattern recognition receptor signaling pathway (GO:0002753)2.31135383
148lymph vessel development (GO:0001945)2.30920882
149detection of other organism (GO:0098543)2.30703606
150positive regulation by host of viral transcription (GO:0043923)2.30659204
151regulation of chromatin silencing (GO:0031935)2.30328313
152regulation of gamma-delta T cell activation (GO:0046643)2.29845455
153regulation of B cell receptor signaling pathway (GO:0050855)2.28656756
154endoderm formation (GO:0001706)2.28445616
155alpha-beta T cell differentiation involved in immune response (GO:0002293)2.28417378
156alpha-beta T cell activation involved in immune response (GO:0002287)2.28417378
157T cell differentiation involved in immune response (GO:0002292)2.28417378
158positive regulation of protein import into nucleus, translocation (GO:0033160)2.28245013
159cell differentiation involved in kidney development (GO:0061005)2.27844826
160viral protein processing (GO:0019082)2.26496075
161positive regulation of DNA-dependent DNA replication (GO:2000105)2.25846216
162myeloid cell development (GO:0061515)2.25779996
163N-terminal protein amino acid acetylation (GO:0006474)2.25714643
164detection of bacterium (GO:0016045)2.23441260
165alpha-beta T cell differentiation (GO:0046632)2.22946952
166negative regulation of erythrocyte differentiation (GO:0045647)2.22849469
167regulation of interleukin-12 biosynthetic process (GO:0045075)2.21573196
168positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)2.19294480
169gland morphogenesis (GO:0022612)2.18715634
170neural tube formation (GO:0001841)2.18577838
171B cell homeostasis (GO:0001782)2.18256730

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.70700836
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.78879708
3SCL_19346495_ChIP-Seq_HPC-7_Human3.74893008
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.73563297
5TP63_19390658_ChIP-ChIP_HaCaT_Human3.66764338
6IRF8_22096565_ChIP-ChIP_GC-B_Human3.33078081
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.99772055
8GATA1_22025678_ChIP-Seq_K562_Human2.96643934
9BP1_19119308_ChIP-ChIP_Hs578T_Human2.88878600
10RUNX_20019798_ChIP-Seq_JUKART_Human2.59562981
11STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.52818388
12NOTCH1_21737748_ChIP-Seq_TLL_Human2.44937785
13CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.40121583
14CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.37881998
15SMAD_19615063_ChIP-ChIP_OVARY_Human2.36968794
16* GATA2_21666600_ChIP-Seq_HMVEC_Human2.35400964
17EGR1_19374776_ChIP-ChIP_THP-1_Human2.21964057
18* FLI1_27457419_Chip-Seq_LIVER_Mouse2.12928984
19ELF1_17652178_ChIP-ChIP_JURKAT_Human2.05342817
20POU3F2_20337985_ChIP-ChIP_501MEL_Human2.04938164
21* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.99702275
22VDR_22108803_ChIP-Seq_LS180_Human1.99418426
23FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.99252300
24IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.98783207
25ZNF274_21170338_ChIP-Seq_K562_Hela1.94510587
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.91007733
27FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.90537272
28MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.85368988
29TAF15_26573619_Chip-Seq_HEK293_Human1.83830460
30* PCGF2_27294783_Chip-Seq_NPCs_Mouse1.77464764
31SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.77370450
32IGF1R_20145208_ChIP-Seq_DFB_Human1.77023426
33LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.74470458
34SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.71938578
35SALL1_21062744_ChIP-ChIP_HESCs_Human1.68122667
36FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.67551508
37* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.65806527
38VDR_24787735_ChIP-Seq_THP-1_Human1.64100206
39GBX2_23144817_ChIP-Seq_PC3_Human1.63599472
40RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.61718916
41BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.61649391
42* NFE2_27457419_Chip-Seq_LIVER_Mouse1.57847812
43ER_23166858_ChIP-Seq_MCF-7_Human1.57279761
44EWS_26573619_Chip-Seq_HEK293_Human1.52730127
45* EZH2_27294783_Chip-Seq_NPCs_Mouse1.46927733
46GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.46547813
47POU5F1_16153702_ChIP-ChIP_HESCs_Human1.45852902
48IRF8_21731497_ChIP-ChIP_J774_Mouse1.45628433
49STAT4_19710469_ChIP-ChIP_TH1__Mouse1.44515927
50MYB_26560356_Chip-Seq_TH2_Human1.41370531
51SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.39764844
52BCAT_22108803_ChIP-Seq_LS180_Human1.39091383
53VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.35405687
54IRF8_27001747_Chip-Seq_BMDM_Mouse1.34465189
55MYB_26560356_Chip-Seq_TH1_Human1.33057439
56OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31408261
57ZNF217_24962896_ChIP-Seq_MCF-7_Human1.30462046
58SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.29702725
59SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29674495
60* IRF1_19129219_ChIP-ChIP_H3396_Human1.28390602
61CTBP2_25329375_ChIP-Seq_LNCAP_Human1.26909232
62* ELK1_19687146_ChIP-ChIP_HELA_Human1.26773056
63EZH2_22144423_ChIP-Seq_EOC_Human1.26741333
64SMAD4_21799915_ChIP-Seq_A2780_Human1.26475301
65UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.25803814
66CDX2_19796622_ChIP-Seq_MESCs_Mouse1.24954299
67* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.24692691
68E2F1_18555785_Chip-Seq_ESCs_Mouse1.24404544
69TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.22976089
70NR3C1_21868756_ChIP-Seq_MCF10A_Human1.21352544
71* STAT3_18555785_Chip-Seq_ESCs_Mouse1.20899240
72IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.20457867
73CBP_20019798_ChIP-Seq_JUKART_Human1.20457867
74ZFP57_27257070_Chip-Seq_ESCs_Mouse1.20046531
75MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.19822025
76PRDM14_20953172_ChIP-Seq_ESCs_Human1.19598544
77FLI1_21867929_ChIP-Seq_TH2_Mouse1.19115416
78POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.18697253
79TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18697253
80NANOG_18555785_Chip-Seq_ESCs_Mouse1.18418896
81STAT3_23295773_ChIP-Seq_U87_Human1.17249425
82* NMYC_18555785_Chip-Seq_ESCs_Mouse1.16709532
83HOXB4_20404135_ChIP-ChIP_EML_Mouse1.16309873
84* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.16252566
85* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.15318775
86AR_21572438_ChIP-Seq_LNCaP_Human1.14898007
87STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.14667571
88CTBP1_25329375_ChIP-Seq_LNCAP_Human1.14621976
89MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.14565762
90* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.14371294
91CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.14204294
92FUS_26573619_Chip-Seq_HEK293_Human1.13803038
93WT1_19549856_ChIP-ChIP_CCG9911_Human1.13354854
94TCF4_23295773_ChIP-Seq_U87_Human1.12436259
95AR_25329375_ChIP-Seq_VCAP_Human1.12376549
96P300_19829295_ChIP-Seq_ESCs_Human1.12132330
97E2F7_22180533_ChIP-Seq_HELA_Human1.11354912
98* P53_22387025_ChIP-Seq_ESCs_Mouse1.10909396
99SMRT_27268052_Chip-Seq_Bcells_Human1.10869647
100* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.10802008
101SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.08526278
102ESR1_21235772_ChIP-Seq_MCF-7_Human1.07946386
103TP53_16413492_ChIP-PET_HCT116_Human1.07599421
104CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07280538
105SMAD3_21741376_ChIP-Seq_EPCs_Human1.06740765
106TOP2B_26459242_ChIP-Seq_MCF-7_Human1.06238429
107PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.05974347
108CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.05517644
109PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04958655
110* P300_18555785_Chip-Seq_ESCs_Mouse1.04156163
111* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.04129448
112* CMYC_18555785_Chip-Seq_ESCs_Mouse1.03404702
113* OCT4_18555785_Chip-Seq_ESCs_Mouse1.02986709
114TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02715368
115* RUNX1_27457419_Chip-Seq_LIVER_Mouse1.02632694
116FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.02388420
117* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.01951159
118AHR_22903824_ChIP-Seq_MCF-7_Human1.00269189
119GATA3_26560356_Chip-Seq_TH2_Human1.00122525
120RBPJ_22232070_ChIP-Seq_NCS_Mouse1.00009136
121RUNX2_22187159_ChIP-Seq_PCA_Human0.99613474
122PIAS1_25552417_ChIP-Seq_VCAP_Human0.99054569
123* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.98536426
124LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.98435320
125SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.98164927
126SPI1_23547873_ChIP-Seq_NB4_Human0.98155930
127Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.97772262
128RXR_22108803_ChIP-Seq_LS180_Human0.97494163
129* ZFX_18555785_Chip-Seq_ESCs_Mouse0.97115542
130TCF4_22108803_ChIP-Seq_LS180_Human0.95382678
131* PU1_27457419_Chip-Seq_LIVER_Mouse0.94879884
132* SOX2_18555785_Chip-Seq_ESCs_Mouse0.94832194
133RNF2_27304074_Chip-Seq_NSC_Mouse0.94145696
134* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.93998076
135TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.93980943
136AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.93942583
137* KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.92788508
138* CIITA_25753668_ChIP-Seq_RAJI_Human0.92549293
139* CRX_20693478_ChIP-Seq_RETINA_Mouse0.92288532
140TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92253790
141GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.91897631
142EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.91878298
143GATA3_27048872_Chip-Seq_THYMUS_Human0.91602735

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode4.06882572
2MP0002877_abnormal_melanocyte_morpholog2.84808910
3MP0002396_abnormal_hematopoietic_system2.81897593
4MP0002132_abnormal_respiratory_system2.78475585
5MP0003787_abnormal_imprinting2.73858168
6MP0002009_preneoplasia2.70188253
7MP0000566_synostosis2.67271368
8MP0005409_darkened_coat_color2.51116584
9MP0005075_abnormal_melanosome_morpholog2.47364949
10MP0000569_abnormal_digit_pigmentation2.41155780
11MP0003763_abnormal_thymus_physiology2.34750672
12MP0001835_abnormal_antigen_presentation2.30478802
13MP0003436_decreased_susceptibility_to2.29704648
14MP0001188_hyperpigmentation2.28991746
15MP0005646_abnormal_pituitary_gland2.28934163
16MP0008007_abnormal_cellular_replicative2.15611017
17MP0005671_abnormal_response_to2.12380220
18MP0003943_abnormal_hepatobiliary_system2.03605168
19MP0008877_abnormal_DNA_methylation1.99572847
20MP0002277_abnormal_respiratory_mucosa1.82939833
21MP0000015_abnormal_ear_pigmentation1.72512784
22MP0004808_abnormal_hematopoietic_stem1.72241756
23MP0003880_abnormal_central_pattern1.71133711
24MP0003303_peritoneal_inflammation1.67967671
25MP0002938_white_spotting1.66890147
26MP0002095_abnormal_skin_pigmentation1.65194765
27MP0002166_altered_tumor_susceptibility1.64199728
28MP0001879_abnormal_lymphatic_vessel1.61265820
29MP0002102_abnormal_ear_morphology1.60697622
30MP0000372_irregular_coat_pigmentation1.59120091
31MP0004264_abnormal_extraembryonic_tissu1.58208512
32MP0009697_abnormal_copulation1.55899357
33MP0001501_abnormal_sleep_pattern1.55710132
34MP0001800_abnormal_humoral_immune1.55663749
35MP0005174_abnormal_tail_pigmentation1.55505613
36MP0002876_abnormal_thyroid_physiology1.52977902
37MP0009764_decreased_sensitivity_to1.52890818
38MP0004782_abnormal_surfactant_physiolog1.48994146
39MP0000681_abnormal_thyroid_gland1.47737534
40MP0000678_abnormal_parathyroid_gland1.45925732
41MP0008057_abnormal_DNA_replication1.45727149
42MP0003183_abnormal_peptide_metabolism1.45626342
43MP0001790_abnormal_immune_system1.43614875
44MP0005387_immune_system_phenotype1.43614875
45MP0004147_increased_porphyrin_level1.41114531
46MP0001986_abnormal_taste_sensitivity1.40186666
47MP0003279_aneurysm1.39973210
48MP0002138_abnormal_hepatobiliary_system1.35614913
49MP0002420_abnormal_adaptive_immunity1.35371953
50MP0002398_abnormal_bone_marrow1.34434694
51MP0003121_genomic_imprinting1.33366555
52MP0003890_abnormal_embryonic-extraembry1.33353504
53MP0002452_abnormal_antigen_presenting1.30775896
54MP0001919_abnormal_reproductive_system1.30470103
55MP0001819_abnormal_immune_cell1.30200835
56MP0006072_abnormal_retinal_apoptosis1.30197847
57MP0002928_abnormal_bile_duct1.27217504
58MP0004883_abnormal_blood_vessel1.27105171
59MP0002638_abnormal_pupillary_reflex1.26399642
60MP0005171_absent_coat_pigmentation1.25813491
61MP0002006_tumorigenesis1.22808123
62MP0008995_early_reproductive_senescence1.22706152
63MP0005000_abnormal_immune_tolerance1.22086329
64MP0003866_abnormal_defecation1.22026442
65MP0002822_catalepsy1.21859525
66MP0003941_abnormal_skin_development1.21690031
67MP0005408_hypopigmentation1.21259516
68MP0002723_abnormal_immune_serum1.19515296
69MP0010368_abnormal_lymphatic_system1.18808596
70MP0001845_abnormal_inflammatory_respons1.16930953
71MP0001186_pigmentation_phenotype1.16784406
72MP0002075_abnormal_coat/hair_pigmentati1.15881703
73MP0001853_heart_inflammation1.15638397
74MP0003786_premature_aging1.14860260
75MP0001851_eye_inflammation1.13092319
76MP0001293_anophthalmia1.13063820
77MP0000716_abnormal_immune_system1.13033824
78MP0005253_abnormal_eye_physiology1.12212117
79MP0003656_abnormal_erythrocyte_physiolo1.11807089
80MP0009785_altered_susceptibility_to1.11555099
81MP0000689_abnormal_spleen_morphology1.11286673
82MP0005464_abnormal_platelet_physiology1.11169322
83MP0000703_abnormal_thymus_morphology1.09835972
84MP0003724_increased_susceptibility_to1.09304871
85MP0000685_abnormal_immune_system1.08532531
86MP0005397_hematopoietic_system_phenotyp1.08501195
87MP0001545_abnormal_hematopoietic_system1.08501195
88MP0006082_CNS_inflammation1.07532844
89MP0002148_abnormal_hypersensitivity_rea1.06813553
90MP0004381_abnormal_hair_follicle1.06509952
91MP0004043_abnormal_pH_regulation1.06481178
92MP0000371_diluted_coat_color1.05537083
93MP0003195_calcinosis1.05151227
94MP0000767_abnormal_smooth_muscle1.04928353
95MP0003300_gastrointestinal_ulcer1.04622568
96MP0005389_reproductive_system_phenotype1.03387370
97MP0005367_renal/urinary_system_phenotyp1.03170897
98MP0000516_abnormal_urinary_system1.03170897
99MP0002060_abnormal_skin_morphology1.03123649
100MP0002419_abnormal_innate_immunity1.01918619
101MP0001486_abnormal_startle_reflex1.01214579
102MP0002722_abnormal_immune_system1.00063594
103MP0004885_abnormal_endolymph0.98958037
104MP0005379_endocrine/exocrine_gland_phen0.97217733
105MP0004947_skin_inflammation0.96159137
106MP0002429_abnormal_blood_cell0.95963409
107MP0001177_atelectasis0.95483831
108MP0002933_joint_inflammation0.95322566
109MP0005167_abnormal_blood-brain_barrier0.95244431
110MP0001533_abnormal_skeleton_physiology0.94862861
111MP0008961_abnormal_basal_metabolism0.94417446
112MP0002254_reproductive_system_inflammat0.93307858
113MP0008058_abnormal_DNA_repair0.92615141
114MP0005508_abnormal_skeleton_morphology0.91364719
115MP0005551_abnormal_eye_electrophysiolog0.91362436
116MP0005025_abnormal_response_to0.91081572
117MP0002405_respiratory_system_inflammati0.90239791
118MP0009745_abnormal_behavioral_response0.89474597
119MP0010155_abnormal_intestine_physiology0.89370601
120MP0000465_gastrointestinal_hemorrhage0.88842067
121MP0005310_abnormal_salivary_gland0.88833787
122MP0003828_pulmonary_edema0.87546542
123MP0001119_abnormal_female_reproductive0.86228551
124MP0000249_abnormal_blood_vessel0.85765892
125MP0004484_altered_response_of0.85187598
126MP0005394_taste/olfaction_phenotype0.82488876
127MP0005499_abnormal_olfactory_system0.82488876
128MP0009333_abnormal_splenocyte_physiolog0.81548279
129MP0001191_abnormal_skin_condition0.80894838
130MP0001873_stomach_inflammation0.80150029
131MP0003252_abnormal_bile_duct0.77472889
132MP0008469_abnormal_protein_level0.76533661
133MP0001968_abnormal_touch/_nociception0.75325781
134MP0002160_abnormal_reproductive_system0.74287799
135MP0004742_abnormal_vestibular_system0.74128131
136MP0002177_abnormal_outer_ear0.74072753
137MP0000427_abnormal_hair_cycle0.73766473
138MP0001502_abnormal_circadian_rhythm0.72859866
139MP0000613_abnormal_salivary_gland0.72577846
140MP0005645_abnormal_hypothalamus_physiol0.72418086
141MP0004142_abnormal_muscle_tone0.71763666
142MP0005164_abnormal_response_to0.70999558
143MP0002735_abnormal_chemical_nociception0.69770553
144MP0000383_abnormal_hair_follicle0.69688704
145MP0005535_abnormal_body_temperature0.68657607
146MP0009765_abnormal_xenobiotic_induced0.67895943
147MP0004924_abnormal_behavior0.67510207
148MP0005386_behavior/neurological_phenoty0.67510207
149MP0003045_fibrosis0.66453457
150MP0002272_abnormal_nervous_system0.66444143

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)5.00260419
2Abnormal hair whorl (HP:0010721)3.94081177
3Elevated erythrocyte sedimentation rate (HP:0003565)3.88375371
4Abnormality of the fingertips (HP:0001211)3.71020037
5T lymphocytopenia (HP:0005403)3.66981849
6Thyroiditis (HP:0100646)3.60656531
7Abnormality of T cell number (HP:0011839)3.51233205
8Severe combined immunodeficiency (HP:0004430)3.30643054
9Abnormality of the columella (HP:0009929)3.29726904
10Panhypogammaglobulinemia (HP:0003139)3.25658615
11Absent frontal sinuses (HP:0002688)3.22604928
12Spinal cord lesions (HP:0100561)3.17961337
13Syringomyelia (HP:0003396)3.17961337
14Abnormal delayed hypersensitivity skin test (HP:0002963)3.06887338
15Gastrointestinal infarctions (HP:0005244)3.06135691
16Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)3.04868700
17Stomach cancer (HP:0012126)3.02944287
18Lip pit (HP:0100267)2.99887095
19Abnormality of the frontal sinuses (HP:0002687)2.99475745
20Hyperventilation (HP:0002883)2.96772559
21Abnormality of eosinophils (HP:0001879)2.95392249
22IgG deficiency (HP:0004315)2.92747691
23Abnormality of the nasal septum (HP:0000419)2.91017337
24Abnormality of incisor morphology (HP:0011063)2.88738359
25Eczematoid dermatitis (HP:0000976)2.82329222
26Papilledema (HP:0001085)2.77200335
27Prostate neoplasm (HP:0100787)2.76879345
28Short middle phalanx of the 5th finger (HP:0004220)2.76642090
29Recurrent cutaneous fungal infections (HP:0011370)2.73381121
30Chronic mucocutaneous candidiasis (HP:0002728)2.73381121
31Recurrent bacterial skin infections (HP:0005406)2.72457631
32Abnormality of T cells (HP:0002843)2.71851214
33Chromsome breakage (HP:0040012)2.70325718
34Neonatal hypoglycemia (HP:0001998)2.70290866
35Chromosomal breakage induced by crosslinking agents (HP:0003221)2.67462646
36Hypothermia (HP:0002045)2.64869048
37Leukocytosis (HP:0001974)2.64650043
38Vasculitis (HP:0002633)2.62639171
39Recurrent bronchitis (HP:0002837)2.61040842
40Alveolar cell carcinoma (HP:0006519)2.60844267
41Hypochromic microcytic anemia (HP:0004840)2.60833794
42White forelock (HP:0002211)2.59871720
43Renal cortical cysts (HP:0000803)2.50663404
44Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.50498046
45Eosinophilia (HP:0001880)2.49685123
46Chronic diarrhea (HP:0002028)2.48232173
47Febrile seizures (HP:0002373)2.48201122
48Hemoptysis (HP:0002105)2.47703017
49Recurrent abscess formation (HP:0002722)2.46967326
50Neoplasm of the tracheobronchial system (HP:0100552)2.46678370
51Absent speech (HP:0001344)2.46006568
52Patchy hypopigmentation of hair (HP:0011365)2.44736816
53Agammaglobulinemia (HP:0004432)2.43161486
54Amyotrophic lateral sclerosis (HP:0007354)2.40799850
55Autoimmune hemolytic anemia (HP:0001890)2.40096686
56Retrobulbar optic neuritis (HP:0100654)2.39790849
57Optic neuritis (HP:0100653)2.39790849
58Widely spaced teeth (HP:0000687)2.39294629
59Acute myeloid leukemia (HP:0004808)2.39278119
60Abnormality of the parietal bone (HP:0002696)2.39213506
61Myositis (HP:0100614)2.39161837
62Hypoplasia of the fovea (HP:0007750)2.38846439
63Aplasia/Hypoplasia of the fovea (HP:0008060)2.38846439
64Chest pain (HP:0100749)2.34916721
65Metaphyseal dysplasia (HP:0100255)2.34554266
66Protruding tongue (HP:0010808)2.34427174
67Nasolacrimal duct obstruction (HP:0000579)2.34393788
68Type I transferrin isoform profile (HP:0003642)2.34309127
69Median cleft lip (HP:0000161)2.31992090
70Reduced antithrombin III activity (HP:0001976)2.31652056
71Recurrent sinusitis (HP:0011108)2.31026438
72Abnormality of the incisor (HP:0000676)2.30318316
73Clubbing of toes (HP:0100760)2.28853737
74Recurrent skin infections (HP:0001581)2.26724920
75Recurrent viral infections (HP:0004429)2.26604891
76Pancreatic cysts (HP:0001737)2.26419452
77Combined immunodeficiency (HP:0005387)2.26127923
78Aplastic anemia (HP:0001915)2.24157460
79True hermaphroditism (HP:0010459)2.23979112
80Generalized hypopigmentation of hair (HP:0011358)2.23512396
81Prolonged bleeding time (HP:0003010)2.19176743
82Orchitis (HP:0100796)2.18526084
83Congenital stationary night blindness (HP:0007642)2.17754352
84Depressed nasal tip (HP:0000437)2.15186025
85Abnormality of the pleura (HP:0002103)2.13334544
86Abnormality of the nasolacrimal system (HP:0000614)2.13272506
87Pulmonary embolism (HP:0002204)2.13168714
88IgM deficiency (HP:0002850)2.11730065
89Gangrene (HP:0100758)2.10213468
90Degeneration of the lateral corticospinal tracts (HP:0002314)2.08336025
91Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.08336025
92Pustule (HP:0200039)2.08012428
93Gaze-evoked nystagmus (HP:0000640)2.07209174
94Intestinal fistula (HP:0100819)2.06499794
95Medial flaring of the eyebrow (HP:0010747)2.06396939
96Hematochezia (HP:0002573)2.06144352
97Recurrent gram-negative bacterial infections (HP:0005420)2.04097075
98Abnormality of the prostate (HP:0008775)2.03439116
99Tubulointerstitial nephritis (HP:0001970)2.02553416
100Granulocytopenia (HP:0001913)2.02334668
101Abnormality of the renal collecting system (HP:0004742)2.01664992
102Fair hair (HP:0002286)2.01482625
103Pulmonary infiltrates (HP:0002113)1.99949039
104Abnormality of the heme biosynthetic pathway (HP:0010472)1.97071937
105Abnormality of the renal medulla (HP:0100957)1.96628124
106Spontaneous hematomas (HP:0007420)1.96401528
107Mesomelia (HP:0003027)1.95508050
108Absent/shortened dynein arms (HP:0200106)1.94762409
109Dynein arm defect of respiratory motile cilia (HP:0012255)1.94762409
110Ectopic kidney (HP:0000086)1.94001604
111Abnormality of the lacrimal duct (HP:0011481)1.92876035
112Renal dysplasia (HP:0000110)1.92815909
113Hypokalemic alkalosis (HP:0001949)1.92554593
114Dry hair (HP:0011359)1.91331530
115Abnormality of the axillary hair (HP:0100134)1.90668872
116Abnormality of secondary sexual hair (HP:0009888)1.90668872
117Bronchitis (HP:0012387)1.90038678
118Chronic hepatic failure (HP:0100626)1.89527744
119Chronic sinusitis (HP:0011109)1.88971117
120Myelodysplasia (HP:0002863)1.88690280
121Hemiplegia (HP:0002301)1.88646828
122Limb hypertonia (HP:0002509)1.87975521
123Keratoconjunctivitis sicca (HP:0001097)1.87726787
124Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.86715757
125Abnormal protein N-linked glycosylation (HP:0012347)1.86715757
126Abnormal protein glycosylation (HP:0012346)1.86715757
127Abnormal glycosylation (HP:0012345)1.86715757
128Pancreatic fibrosis (HP:0100732)1.84864438
129Chronic otitis media (HP:0000389)1.84414866
130Volvulus (HP:0002580)1.84237051
131Genetic anticipation (HP:0003743)1.83223816
132Keratitis (HP:0000491)1.83178837
133Attenuation of retinal blood vessels (HP:0007843)1.82943853
134Long eyelashes (HP:0000527)1.82031305
135Hypoplasia of the thymus (HP:0000778)1.81425634
136Keratoconjunctivitis (HP:0001096)1.78181630
137Abnormality of the fovea (HP:0000493)1.77947059
138Abnormality of binocular vision (HP:0011514)1.77489614
139Diplopia (HP:0000651)1.77489614
140Sparse scalp hair (HP:0002209)1.76450416
141Abnormality of T cell physiology (HP:0011840)1.76395927
142Abnormal rod and cone electroretinograms (HP:0008323)1.75588742
143Papilloma (HP:0012740)1.75334201
144Verrucae (HP:0200043)1.75334201
145Hypoplastic labia majora (HP:0000059)1.74837529
146Polydipsia (HP:0001959)1.74678043
147Abnormal drinking behavior (HP:0030082)1.74678043
148Nephronophthisis (HP:0000090)1.72748517
149Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.71252702
150Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.69333965
151Postaxial foot polydactyly (HP:0001830)1.68781442
152B lymphocytopenia (HP:0010976)1.68333701
153Abnormality of B cell number (HP:0010975)1.68333701
154Spondylolisthesis (HP:0003302)1.67129119
155Encephalitis (HP:0002383)1.66798124
156Aplasia cutis congenita (HP:0001057)1.66783653
157Abnormality of the renal cortex (HP:0011035)1.65731433
158Aplasia/Hypoplasia of the macula (HP:0008059)1.65491938
159Nephroblastoma (Wilms tumor) (HP:0002667)1.64943131
160Hypoproteinemia (HP:0003075)1.63883600
161Lymphopenia (HP:0001888)1.63802043
162Mediastinal lymphadenopathy (HP:0100721)1.63767506
163Abnormality of chromosome stability (HP:0003220)1.63673094
164Distal lower limb muscle weakness (HP:0009053)1.62795430
165Embryonal renal neoplasm (HP:0011794)1.62180903
166Pancreatic islet-cell hyperplasia (HP:0004510)1.61521705
167Intestinal atresia (HP:0011100)1.61315606
168Recurrent fungal infections (HP:0002841)1.61296193
169Meningitis (HP:0001287)1.60073882
170Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.59736999

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BRD44.33938201
2MAP3K142.81109425
3TIE12.76041109
4MKNK22.64723868
5TXK2.64369578
6ACVR1B2.42010749
7ZAK2.38398096
8INSRR2.37429295
9NEK62.09651687
10TEC2.08318139
11TNIK2.00824754
12ERBB31.95527877
13IRAK31.88364344
14MKNK11.81838709
15STK241.78781481
16IRAK41.78348186
17IRAK11.76378572
18SIK31.73376889
19SGK21.64241826
20PRPF4B1.60780435
21CDK81.60637486
22CDK121.57400737
23FES1.55452490
24RIPK41.55413322
25IKBKE1.54754767
26CHUK1.52036208
27MAPK151.51578782
28NLK1.51538127
29AKT31.48200077
30KIT1.47764967
31TGFBR21.44643995
32CAMKK21.41432439
33IKBKB1.38490924
34PIK3CA1.37285418
35MAP4K21.36737599
36STK38L1.36591694
37BMPR1B1.33192488
38MAP3K131.32621084
39MAPK71.31909866
40FRK1.30362116
41ADRBK21.30169297
42BMPR21.29173903
43MAP4K11.29111350
44GRK11.27691801
45TNK21.26862847
46GRK61.24220994
47FGFR31.21888309
48JAK31.20465672
49CLK11.20170796
50BTK1.18506460
51SIK21.16212421
52SGK31.12765602
53ITK1.12532798
54YES11.12483925
55BLK1.12125949
56TBK11.11384681
57BRSK21.03158587
58NUAK11.02964531
59CSF1R1.02759786
60FLT31.01723671
61CSK1.00717281
62HCK0.98443374
63PINK10.94477606
64EPHA30.94275560
65CDK90.92476123
66HIPK20.89504896
67IRAK20.86159412
68TRPM70.82914470
69CASK0.82424760
70CAMK40.82402123
71NEK90.81568593
72TRIM280.81551196
73CDK30.80750875
74MAP2K20.80728328
75PLK40.80485514
76UHMK10.80196132
77MAP3K40.78586823
78PAK30.77343421
79DYRK1B0.77120140
80SRPK10.76730456
81VRK10.75985347
82JAK20.75196763
83DAPK20.74099441
84MAP3K70.73958676
85MAP2K30.73768513
86SGK4940.73178486
87SGK2230.73178486
88TAOK30.70428017
89PIK3CG0.70331738
90PRKCQ0.70171096
91ATR0.69120962
92MAP3K30.69030291
93GRK70.68810921
94PNCK0.68088494
95TSSK60.66279508
96OXSR10.65726253
97TGFBR10.64184592
98PTK2B0.63834381
99MYLK0.61475664
100MST40.60015586
101MAP3K20.57611608
102PIM10.57240478
103WNK30.56697208
104RPS6KB10.56546735
105RPS6KA50.54949653
106FGR0.54399609
107STK110.53685027
108CDK70.51890373
109NTRK20.51539361
110WNK10.51023285
111MAPK130.50582918
112MARK30.50183558
113MAPK30.48392560
114ABL10.48371239
115LCK0.47805492
116DYRK1A0.47235939
117MATK0.46847529
118SYK0.46834122
119MAP3K120.46521797
120IGF1R0.44900740
121EGFR0.43905185
122RPS6KA40.43795106
123EPHA40.43638344
124BCR0.42879885
125LYN0.42206317
126TYK20.40459999
127STK30.40239221
128EIF2AK20.39974603
129RPS6KA60.39416029
130ATM0.38099754
131FGFR20.37699242
132ZAP700.37549365
133MUSK0.37472642
134PASK0.37393510
135MAPKAPK50.37067051
136JAK10.35573189
137TAOK20.35427856
138MAPK120.35215056

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002323.27699836
2Asthma_Homo sapiens_hsa053102.71535511
3Primary immunodeficiency_Homo sapiens_hsa053402.26310191
4Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.17212022
5Transcriptional misregulation in cancer_Homo sapiens_hsa052022.07923766
6NF-kappa B signaling pathway_Homo sapiens_hsa040642.00682599
7Intestinal immune network for IgA production_Homo sapiens_hsa046721.95855102
8Staphylococcus aureus infection_Homo sapiens_hsa051501.91913824
9Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.88412333
10Hematopoietic cell lineage_Homo sapiens_hsa046401.86809178
11Herpes simplex infection_Homo sapiens_hsa051681.78963308
12Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.76331398
13Measles_Homo sapiens_hsa051621.67046493
14RNA degradation_Homo sapiens_hsa030181.65879313
15Basal transcription factors_Homo sapiens_hsa030221.62474220
16Non-homologous end-joining_Homo sapiens_hsa034501.61823609
17RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.60211432
18SNARE interactions in vesicular transport_Homo sapiens_hsa041301.56314223
19Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.55178676
20Fanconi anemia pathway_Homo sapiens_hsa034601.46385320
21Base excision repair_Homo sapiens_hsa034101.46191997
22Circadian rhythm_Homo sapiens_hsa047101.42567023
23Protein export_Homo sapiens_hsa030601.41102384
24Maturity onset diabetes of the young_Homo sapiens_hsa049501.37766004
25Jak-STAT signaling pathway_Homo sapiens_hsa046301.37305628
26Dorso-ventral axis formation_Homo sapiens_hsa043201.34848960
27Allograft rejection_Homo sapiens_hsa053301.33842762
28Arachidonic acid metabolism_Homo sapiens_hsa005901.32435904
29B cell receptor signaling pathway_Homo sapiens_hsa046621.29583662
30Homologous recombination_Homo sapiens_hsa034401.27618559
31Leishmaniasis_Homo sapiens_hsa051401.27386723
32NOD-like receptor signaling pathway_Homo sapiens_hsa046211.26466943
33Viral myocarditis_Homo sapiens_hsa054161.25696652
34Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.22849272
35Regulation of autophagy_Homo sapiens_hsa041401.21182566
36Influenza A_Homo sapiens_hsa051641.19756207
37Tuberculosis_Homo sapiens_hsa051521.17449664
38Toll-like receptor signaling pathway_Homo sapiens_hsa046201.15286967
39Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.09872572
40Graft-versus-host disease_Homo sapiens_hsa053321.09097104
41Autoimmune thyroid disease_Homo sapiens_hsa053201.05441788
42Phototransduction_Homo sapiens_hsa047441.04173547
43Acute myeloid leukemia_Homo sapiens_hsa052211.03444926
44T cell receptor signaling pathway_Homo sapiens_hsa046601.00224835
45TNF signaling pathway_Homo sapiens_hsa046680.99390122
46Osteoclast differentiation_Homo sapiens_hsa043800.98096738
47Prostate cancer_Homo sapiens_hsa052150.96285477
48Hepatitis B_Homo sapiens_hsa051610.95684829
49Linoleic acid metabolism_Homo sapiens_hsa005910.94867720
50Thyroid cancer_Homo sapiens_hsa052160.92194250
51Antigen processing and presentation_Homo sapiens_hsa046120.91744844
52* Legionellosis_Homo sapiens_hsa051340.90885768
53Nicotine addiction_Homo sapiens_hsa050330.89104942
54Nitrogen metabolism_Homo sapiens_hsa009100.87683115
55Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.86651320
56Amphetamine addiction_Homo sapiens_hsa050310.85701265
57Notch signaling pathway_Homo sapiens_hsa043300.84701095
58Toxoplasmosis_Homo sapiens_hsa051450.83756340
59Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.82141041
60alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.79241319
61FoxO signaling pathway_Homo sapiens_hsa040680.78349995
62Renin secretion_Homo sapiens_hsa049240.77610644
63HTLV-I infection_Homo sapiens_hsa051660.76433160
64Morphine addiction_Homo sapiens_hsa050320.74977883
65Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.74633608
66African trypanosomiasis_Homo sapiens_hsa051430.74404809
67RNA polymerase_Homo sapiens_hsa030200.73140193
68Taste transduction_Homo sapiens_hsa047420.72825339
69Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.72801458
70Malaria_Homo sapiens_hsa051440.71970168
71Other glycan degradation_Homo sapiens_hsa005110.71047971
72Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.69898034
73Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.68042745
74Ovarian steroidogenesis_Homo sapiens_hsa049130.68013423
75Circadian entrainment_Homo sapiens_hsa047130.67840420
76Sphingolipid metabolism_Homo sapiens_hsa006000.67779019
77Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.67425499
78Vitamin digestion and absorption_Homo sapiens_hsa049770.67115658
79Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.65756504
80Galactose metabolism_Homo sapiens_hsa000520.65123224
81Chemokine signaling pathway_Homo sapiens_hsa040620.65100961
82Hepatitis C_Homo sapiens_hsa051600.65029509
83Olfactory transduction_Homo sapiens_hsa047400.63464500
84Small cell lung cancer_Homo sapiens_hsa052220.63165429
85Choline metabolism in cancer_Homo sapiens_hsa052310.62990545
86TGF-beta signaling pathway_Homo sapiens_hsa043500.62596194
87Spliceosome_Homo sapiens_hsa030400.62385936
88Cocaine addiction_Homo sapiens_hsa050300.61854621
89Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.61346661
90p53 signaling pathway_Homo sapiens_hsa041150.60149093
91Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.59740375
92Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.58699529
93Platelet activation_Homo sapiens_hsa046110.58157303
94Glutamatergic synapse_Homo sapiens_hsa047240.57779842
95Salivary secretion_Homo sapiens_hsa049700.57741669
96cAMP signaling pathway_Homo sapiens_hsa040240.57018724
97Long-term depression_Homo sapiens_hsa047300.56136391
98Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.56035220
99Glycosaminoglycan degradation_Homo sapiens_hsa005310.55836163
100Prolactin signaling pathway_Homo sapiens_hsa049170.55495241
101Leukocyte transendothelial migration_Homo sapiens_hsa046700.55233827
102Carbohydrate digestion and absorption_Homo sapiens_hsa049730.54628089
103Estrogen signaling pathway_Homo sapiens_hsa049150.54177903
104Apoptosis_Homo sapiens_hsa042100.53688311
105Pathways in cancer_Homo sapiens_hsa052000.53554898
106Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.53033091
107Oxytocin signaling pathway_Homo sapiens_hsa049210.52974660
108Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.52692558
109Serotonergic synapse_Homo sapiens_hsa047260.52388356
110mRNA surveillance pathway_Homo sapiens_hsa030150.51470617
111Aldosterone synthesis and secretion_Homo sapiens_hsa049250.51077548
112MicroRNAs in cancer_Homo sapiens_hsa052060.50647603
113Cholinergic synapse_Homo sapiens_hsa047250.50376553
114Sphingolipid signaling pathway_Homo sapiens_hsa040710.50184629
115Rheumatoid arthritis_Homo sapiens_hsa053230.49613049
116Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.48917930
117Type I diabetes mellitus_Homo sapiens_hsa049400.48653953
118Phosphatidylinositol signaling system_Homo sapiens_hsa040700.48198744
119N-Glycan biosynthesis_Homo sapiens_hsa005100.48151755
120Dopaminergic synapse_Homo sapiens_hsa047280.47148816
121Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.46648392
122Pertussis_Homo sapiens_hsa051330.46620770
123GABAergic synapse_Homo sapiens_hsa047270.46164953
124Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.46104416
125PI3K-Akt signaling pathway_Homo sapiens_hsa041510.45457768
126Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.45112633
127Neurotrophin signaling pathway_Homo sapiens_hsa047220.45091679
128Phospholipase D signaling pathway_Homo sapiens_hsa040720.44088702
129AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.43319660
130GnRH signaling pathway_Homo sapiens_hsa049120.43129700
131MAPK signaling pathway_Homo sapiens_hsa040100.43061939
132Chemical carcinogenesis_Homo sapiens_hsa052040.43054514
133Phagosome_Homo sapiens_hsa041450.42631637
134Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.42066889
135Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.42010675
136Cell cycle_Homo sapiens_hsa041100.41874070
137Ras signaling pathway_Homo sapiens_hsa040140.41718505
138Purine metabolism_Homo sapiens_hsa002300.41118173
139Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.41057068
140Epstein-Barr virus infection_Homo sapiens_hsa051690.41047336
141Renal cell carcinoma_Homo sapiens_hsa052110.40370076
142Ether lipid metabolism_Homo sapiens_hsa005650.39805636
143ABC transporters_Homo sapiens_hsa020100.39403255
144Long-term potentiation_Homo sapiens_hsa047200.39242337
145Adherens junction_Homo sapiens_hsa045200.38069940
146Thyroid hormone signaling pathway_Homo sapiens_hsa049190.37757436
147Inositol phosphate metabolism_Homo sapiens_hsa005620.36556444

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