CLK2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a dual specificity protein kinase that phosphorylates serine/threonine and tyrosine-containing substrates. Activity of this protein regulates serine- and arginine-rich (SR) proteins of the spliceosomal complex, thereby influencing alternative transcript splicing. Chromosomal translocations have been characterized between this locus and the PAFAH1B3 (platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)) gene on chromosome 19, resulting in the production of a fusion protein. Note that this gene is distinct from the TELO2 gene (GeneID:9894), which shares the CLK2 alias, but encodes a protein that is involved in telomere length regulation. There is a pseudogene for this gene on chromosome 7. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mannose metabolic process (GO:0006013)5.03391016
2mitotic sister chromatid cohesion (GO:0007064)4.16514895
3negative regulation of histone methylation (GO:0031061)4.14700022
4positive regulation of gamma-delta T cell activation (GO:0046645)3.95327488
5nuclear pore complex assembly (GO:0051292)3.92951875
6poly(A)+ mRNA export from nucleus (GO:0016973)3.82209961
7pre-miRNA processing (GO:0031054)3.74921736
8nuclear pore organization (GO:0006999)3.59270847
9response to muramyl dipeptide (GO:0032495)3.58013656
10histone H3-K4 trimethylation (GO:0080182)3.55931628
11histone H3-K9 demethylation (GO:0033169)3.53296944
12regulation of histone H3-K9 methylation (GO:0051570)3.51895435
13pore complex assembly (GO:0046931)3.48196586
14negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.46448425
15regulation of translational fidelity (GO:0006450)3.41402058
16regulation of gamma-delta T cell differentiation (GO:0045586)3.40666376
17NIK/NF-kappaB signaling (GO:0038061)3.39729570
18regulation of nucleobase-containing compound transport (GO:0032239)3.39580762
19histone H3-K4 methylation (GO:0051568)3.32702371
20positive thymic T cell selection (GO:0045059)3.25873221
21positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.21585750
22protein localization to kinetochore (GO:0034501)3.17686213
23regulation of gamma-delta T cell activation (GO:0046643)3.17163179
24ribosomal small subunit biogenesis (GO:0042274)3.16160213
25negative regulation of mRNA processing (GO:0050686)3.15507358
26dosage compensation (GO:0007549)3.12794385
27histone lysine demethylation (GO:0070076)3.12591886
28negative regulation of RNA splicing (GO:0033119)3.11206074
29negative regulation of cell killing (GO:0031342)3.09710355
30negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.09710355
31response to peptidoglycan (GO:0032494)3.05156090
32modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.03834703
33positive regulation by organism of defense response of other organism involved in symbiotic interact3.03834703
34modulation by symbiont of host immune response (GO:0052553)3.03834703
35positive regulation by symbiont of host defense response (GO:0052509)3.03834703
36modulation by symbiont of host defense response (GO:0052031)3.03834703
37modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.03834703
38viral transcription (GO:0019083)3.03405450
39positive regulation of histone deacetylation (GO:0031065)3.02234176
40spliceosomal tri-snRNP complex assembly (GO:0000244)3.01240098
41histone H4 deacetylation (GO:0070933)2.98131858
42negative thymic T cell selection (GO:0045060)2.96433506
43DNA duplex unwinding (GO:0032508)2.96076955
44protein localization to chromosome, centromeric region (GO:0071459)2.95759430
45DNA geometric change (GO:0032392)2.95614485
46stress granule assembly (GO:0034063)2.93800763
47modulation by symbiont of host cellular process (GO:0044068)2.93732974
48positive regulation of gene expression, epigenetic (GO:0045815)2.93230388
49mRNA stabilization (GO:0048255)2.93108920
50RNA stabilization (GO:0043489)2.93108920
51positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.92850393
52regulation of ARF GTPase activity (GO:0032312)2.92811848
53germinal center formation (GO:0002467)2.92278123
54histone H3-K36 demethylation (GO:0070544)2.89779981
55phospholipid scrambling (GO:0017121)2.89585718
56histone demethylation (GO:0016577)2.89300845
57negative T cell selection (GO:0043383)2.89052202
58negative regulation of mRNA metabolic process (GO:1903312)2.87622696
59cytoplasmic mRNA processing body assembly (GO:0033962)2.85665806
60mitotic chromosome condensation (GO:0007076)2.84123329
61regulation of interleukin-12 biosynthetic process (GO:0045075)2.83300323
62positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.80477102
63apoptotic process involved in morphogenesis (GO:0060561)2.80067249
64detection of bacterium (GO:0016045)2.79344691
65regulation of type I interferon-mediated signaling pathway (GO:0060338)2.78944638
66DNA unwinding involved in DNA replication (GO:0006268)2.76910018
67histone H2A monoubiquitination (GO:0035518)2.74348820
68regulation of histone H3-K4 methylation (GO:0051569)2.73549537
69CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.72886220
70thymic T cell selection (GO:0045061)2.72167033
71regulation of RNA export from nucleus (GO:0046831)2.70784526
72peptidyl-lysine trimethylation (GO:0018023)2.70145336
73kinetochore organization (GO:0051383)2.69959255
74activation of Rac GTPase activity (GO:0032863)2.69389827
75translational termination (GO:0006415)2.69372292
76sister chromatid segregation (GO:0000819)2.68857058
77cellular response to virus (GO:0098586)2.68477590
78regulation of NFAT protein import into nucleus (GO:0051532)2.68371989
79regulation of sister chromatid cohesion (GO:0007063)2.67442436
803-UTR-mediated mRNA stabilization (GO:0070935)2.66743551
81positive regulation of Cdc42 GTPase activity (GO:0043089)2.65601600
82detection of other organism (GO:0098543)2.65059087
83antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.64598873
84antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.64598873
85histone mRNA catabolic process (GO:0071044)2.64203103
86positive regulation by host of viral transcription (GO:0043923)2.64088046
87histone lysine methylation (GO:0034968)2.64045143
88embryonic process involved in female pregnancy (GO:0060136)2.63202609
89antigen processing and presentation of endogenous antigen (GO:0019883)2.62673278
90regulation of histone methylation (GO:0031060)2.62177336
91nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.62012677
92negative regulation of granulocyte differentiation (GO:0030853)2.60841623
93mitotic nuclear envelope disassembly (GO:0007077)2.59498603
94histone H4-K16 acetylation (GO:0043984)2.58165605
95negative regulation of histone modification (GO:0031057)2.56758433
96regulation of mammary gland epithelial cell proliferation (GO:0033599)2.56454727
97histone deubiquitination (GO:0016578)2.54100327
98protein-DNA complex disassembly (GO:0032986)2.53555699
99nucleosome disassembly (GO:0006337)2.53555699
100Peyers patch development (GO:0048541)2.52901121
101mucosal-associated lymphoid tissue development (GO:0048537)2.52901121
102histone H3-K9 methylation (GO:0051567)2.52396027
103regulation of chromatin binding (GO:0035561)2.51742542
104B cell receptor signaling pathway (GO:0050853)2.51634200
105positive T cell selection (GO:0043368)2.51433584
106positive regulation of granulocyte differentiation (GO:0030854)2.50397765
107negative regulation of gene expression, epigenetic (GO:0045814)2.49818040
108positive regulation of B cell differentiation (GO:0045579)2.48431244
109T cell selection (GO:0045058)2.48162618
110intracellular estrogen receptor signaling pathway (GO:0030520)2.48035789
111protein demethylation (GO:0006482)2.47865818
112protein dealkylation (GO:0008214)2.47865818
113regulation of stem cell maintenance (GO:2000036)2.47189405
114regulation of B cell differentiation (GO:0045577)2.46905416
115negative regulation of chromatin modification (GO:1903309)2.46159945
116cellular response to epidermal growth factor stimulus (GO:0071364)2.45840405
117formation of translation preinitiation complex (GO:0001731)2.45827746
118maternal placenta development (GO:0001893)2.45822394
119histone H3 deacetylation (GO:0070932)2.45511005
120regulation of histone H3-K27 methylation (GO:0061085)2.45467004
121DNA conformation change (GO:0071103)2.44546553
122positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.43889342
123mitotic metaphase plate congression (GO:0007080)2.43731758
124regulation of spindle organization (GO:0090224)2.43475924
125DNA topological change (GO:0006265)2.43118700
126histone H3-K9 modification (GO:0061647)2.42948622
127regulation of DNA endoreduplication (GO:0032875)2.42670145
128mitotic sister chromatid segregation (GO:0000070)2.42510253
129regulation of mitotic spindle organization (GO:0060236)2.41826166
130peptidyl-lysine dimethylation (GO:0018027)2.38713457
131regulation of granulocyte differentiation (GO:0030852)2.38606139
132membrane disassembly (GO:0030397)2.37092735
133nuclear envelope disassembly (GO:0051081)2.37092735
134regulation of B cell receptor signaling pathway (GO:0050855)2.36517651
135metaphase plate congression (GO:0051310)2.36053344
136chromatin assembly (GO:0031497)2.35099510
137DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.34702362
138maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.34109679
139chromatin silencing (GO:0006342)2.33184709
140positive regulation of protein deacetylation (GO:0090312)2.33017821
141heterochromatin organization (GO:0070828)2.32922696
142peptidyl-lysine methylation (GO:0018022)2.32740516
143regulation of mRNA stability (GO:0043488)2.32494883
144negative regulation of erythrocyte differentiation (GO:0045647)2.29840084
145endothelial tube morphogenesis (GO:0061154)2.28246613
146morphogenesis of an endothelium (GO:0003159)2.28246613
147histone methylation (GO:0016571)2.27979647
148kinetochore assembly (GO:0051382)2.27308582
149modulation by virus of host process (GO:0019054)2.26983768
150definitive hemopoiesis (GO:0060216)2.26502854
151histone H3 acetylation (GO:0043966)2.24562845

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.44841698
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.49149661
3EGR1_19374776_ChIP-ChIP_THP-1_Human4.25762043
4MYC_22102868_ChIP-Seq_BL_Human4.06731783
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.04484294
6VDR_21846776_ChIP-Seq_THP-1_Human2.88454100
7E2F4_17652178_ChIP-ChIP_JURKAT_Human2.88108778
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.85457493
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.75449785
10TCF7_22412390_ChIP-Seq_EML_Mouse2.43250693
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.37972082
12SCL_19346495_ChIP-Seq_HPC-7_Human2.31423719
13LXR_22292898_ChIP-Seq_THP-1_Human2.30441877
14CIITA_25753668_ChIP-Seq_RAJI_Human2.16452200
15* KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.10930500
16THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.08061585
17IRF8_22096565_ChIP-ChIP_GC-B_Human2.06926858
18MAF_26560356_Chip-Seq_TH1_Human2.04003522
19UTX_26944678_Chip-Seq_JUKART_Human2.01437252
20* KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.01225971
21ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.00611897
22MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.97879143
23FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.96338993
24KDM2B_26808549_Chip-Seq_DND41_Human1.94300197
25MYB_26560356_Chip-Seq_TH1_Human1.91911832
26MYB_26560356_Chip-Seq_TH2_Human1.89156391
27RACK7_27058665_Chip-Seq_MCF-7_Human1.88894083
28SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.88701201
29TP63_19390658_ChIP-ChIP_HaCaT_Human1.80446878
30HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.76557607
31E2F1_21310950_ChIP-Seq_MCF-7_Human1.76517515
32VDR_24763502_ChIP-Seq_THP-1_Human1.76151789
33IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.73911095
34EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.70477402
35* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.63629713
36KDM2B_26808549_Chip-Seq_K562_Human1.62986329
37KDM2B_26808549_Chip-Seq_SUP-B15_Human1.62838075
38* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.62727172
39STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.61814015
40TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61304512
41MYC_18555785_ChIP-Seq_MESCs_Mouse1.56748290
42* ELK3_25401928_ChIP-Seq_HUVEC_Human1.56639420
43MYB_21317192_ChIP-Seq_ERMYB_Mouse1.54140516
44* SPI1_23547873_ChIP-Seq_NB4_Human1.53449969
45E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.50737788
46BRD4_27068464_Chip-Seq_AML-cells_Mouse1.47722370
47MYC_19079543_ChIP-ChIP_MESCs_Mouse1.44880486
48RUNX1_22412390_ChIP-Seq_EML_Mouse1.44276909
49RUNX_20019798_ChIP-Seq_JUKART_Human1.44243898
50P68_20966046_ChIP-Seq_HELA_Human1.41678791
51ZFP281_18757296_ChIP-ChIP_E14_Mouse1.39397159
52CREB1_26743006_Chip-Seq_LNCaP_Human1.38058272
53MAF_26560356_Chip-Seq_TH2_Human1.37766672
54* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.37342323
55SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.36546687
56CTCF_27219007_Chip-Seq_ERYTHROID_Human1.33964215
57KDM2B_26808549_Chip-Seq_JURKAT_Human1.33882997
58* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.33758142
59NOTCH1_21737748_ChIP-Seq_TLL_Human1.33056067
60NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.32498093
61IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.31952206
62TET1_21451524_ChIP-Seq_MESCs_Mouse1.31298458
63SMC4_20622854_ChIP-Seq_HELA_Human1.29877231
64SA1_27219007_Chip-Seq_ERYTHROID_Human1.29208097
65EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.29046025
66TP63_17297297_ChIP-ChIP_HaCaT_Human1.28531522
67* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.28360613
68SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.27323811
69NCOR1_26117541_ChIP-Seq_K562_Human1.26546192
70STAT4_19710469_ChIP-ChIP_TH1__Mouse1.25672847
71RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.24401406
72BP1_19119308_ChIP-ChIP_Hs578T_Human1.24360909
73CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.23735772
74KDM5A_27292631_Chip-Seq_BREAST_Human1.23428439
75IRF8_27001747_Chip-Seq_BMDM_Mouse1.21836214
76AR_21909140_ChIP-Seq_LNCAP_Human1.21151764
77SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.20744634
78* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.16717804
79KLF4_18555785_ChIP-Seq_MESCs_Mouse1.16574376
80MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.14872871
81SALL1_21062744_ChIP-ChIP_HESCs_Human1.14743267
82SPI1_23127762_ChIP-Seq_K562_Human1.14412363
83CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.11185411
84ZFP281_27345836_Chip-Seq_ESCs_Mouse1.10989592
85RARG_19884340_ChIP-ChIP_MEFs_Mouse1.10889130
86RUNX1_27514584_Chip-Seq_MCF-7_Human1.09992464
87STAT6_21828071_ChIP-Seq_BEAS2B_Human1.07930424
88* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.07715716
89WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.07309540
90STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.07304501
91POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.06916517
92TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.05840023
93* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.05554087
94TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.05347716
95DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.03538119
96* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.03406043
97PU.1_20513432_ChIP-Seq_Bcells_Mouse1.03165278
98ZFX_18555785_ChIP-Seq_MESCs_Mouse1.02561875
99UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.02081208
100TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.01980614
101CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.01732280
102ELF1_20517297_ChIP-Seq_JURKAT_Human1.01539772
103IRF8_21731497_ChIP-ChIP_J774_Mouse1.01005847
104PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00922709
105BCOR_27268052_Chip-Seq_Bcells_Human1.00779555
106ERG_21242973_ChIP-ChIP_JURKAT_Human1.00462296
107GATA1_22383799_ChIP-Seq_G1ME_Mouse1.00334356
108PKCTHETA_26484144_Chip-Seq_BREAST_Human0.99869112
109DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.99865080
110VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.99687051
111* XRN2_22483619_ChIP-Seq_HELA_Human0.99586765
112CTCF_21964334_ChIP-Seq_BJAB-B_Human0.99426501
113MYC_18358816_ChIP-ChIP_MESCs_Mouse0.99370402
114PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.97913051
115GATA1_19941827_ChIP-Seq_MEL_Mouse0.97817492
116SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.96999898
117MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.96005868
118* MYCN_18555785_ChIP-Seq_MESCs_Mouse0.95110095
119FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.92501056
120NFIB_24661679_ChIP-Seq_LUNG_Mouse0.92047319
121GATA2_22383799_ChIP-Seq_G1ME_Mouse0.91682364
122TFEB_21752829_ChIP-Seq_HELA_Human0.91257218
123KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.91137294
124PU_27001747_Chip-Seq_BMDM_Mouse0.90525414
125DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.90471028
126* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.89569424
127RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.88828108
128GATA3_27048872_Chip-Seq_THYMUS_Human0.87471119
129* NELFA_20434984_ChIP-Seq_ESCs_Mouse0.87300448
130YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.87165869
131ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.86856442
132P300_27058665_Chip-Seq_ZR-75-30cells_Human0.85894635
133NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.85127574
134FOXP3_21729870_ChIP-Seq_TREG_Human0.83725284
135NANOG_18555785_ChIP-Seq_MESCs_Mouse0.81954323
136CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.80585088
137FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.80230472

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002396_abnormal_hematopoietic_system3.07097165
2MP0003111_abnormal_nucleus_morphology2.55799179
3MP0010094_abnormal_chromosome_stability2.38882506
4MP0003763_abnormal_thymus_physiology2.38764278
5MP0003693_abnormal_embryo_hatching2.36766898
6MP0005058_abnormal_lysosome_morphology2.35118024
7MP0008057_abnormal_DNA_replication2.31514016
8MP0000685_abnormal_immune_system2.28096416
9MP0003077_abnormal_cell_cycle2.23325706
10MP0004808_abnormal_hematopoietic_stem2.22837881
11MP0005451_abnormal_body_composition2.19365247
12MP0003172_abnormal_lysosome_physiology2.11425970
13MP0002398_abnormal_bone_marrow1.91108845
14MP0009278_abnormal_bone_marrow1.88465629
15MP0004957_abnormal_blastocyst_morpholog1.88081480
16MP0000678_abnormal_parathyroid_gland1.86257326
17MP0010352_gastrointestinal_tract_polyps1.85695532
18MP0001800_abnormal_humoral_immune1.85645939
19MP0005076_abnormal_cell_differentiation1.84901070
20MP0000703_abnormal_thymus_morphology1.81624066
21MP0002166_altered_tumor_susceptibility1.79242203
22MP0001835_abnormal_antigen_presentation1.77613661
23MP0002249_abnormal_larynx_morphology1.76762736
24MP0003705_abnormal_hypodermis_morpholog1.72218561
25MP0008007_abnormal_cellular_replicative1.70169037
26MP0003300_gastrointestinal_ulcer1.70165000
27MP0004381_abnormal_hair_follicle1.67922922
28MP0005666_abnormal_adipose_tissue1.67840495
29MP0010307_abnormal_tumor_latency1.63155282
30MP0000490_abnormal_crypts_of1.62347337
31MP0004264_abnormal_extraembryonic_tissu1.61378929
32MP0000569_abnormal_digit_pigmentation1.58955228
33MP0003453_abnormal_keratinocyte_physiol1.58901485
34MP0005387_immune_system_phenotype1.58387319
35MP0001790_abnormal_immune_system1.58387319
36MP0002722_abnormal_immune_system1.53252303
37MP0003303_peritoneal_inflammation1.51241031
38MP0002452_abnormal_antigen_presenting1.51074637
39MP0008058_abnormal_DNA_repair1.48945796
40MP0000716_abnormal_immune_system1.47382352
41MP0002420_abnormal_adaptive_immunity1.47249950
42MP0000689_abnormal_spleen_morphology1.45733339
43MP0001819_abnormal_immune_cell1.44919081
44MP0002653_abnormal_ependyma_morphology1.44753495
45MP0008260_abnormal_autophagy1.43651793
46MP0000733_abnormal_muscle_development1.43038438
47MP0000465_gastrointestinal_hemorrhage1.42867640
48MP0005671_abnormal_response_to1.41131755
49MP0005397_hematopoietic_system_phenotyp1.40581169
50MP0001545_abnormal_hematopoietic_system1.40581169
51MP0002006_tumorigenesis1.40275220
52MP0000350_abnormal_cell_proliferation1.38482334
53MP0002723_abnormal_immune_serum1.33675548
54MP0002429_abnormal_blood_cell1.32731707
55MP0001730_embryonic_growth_arrest1.32296619
56MP0005380_embryogenesis_phenotype1.29467789
57MP0001672_abnormal_embryogenesis/_devel1.29467789
58MP0003566_abnormal_cell_adhesion1.29352272
59MP0009333_abnormal_splenocyte_physiolog1.28103639
60MP0003183_abnormal_peptide_metabolism1.25395385
61MP0005409_darkened_coat_color1.25233208
62MP0003567_abnormal_fetal_cardiomyocyte1.24204391
63MP0005174_abnormal_tail_pigmentation1.23416941
64MP0003984_embryonic_growth_retardation1.22985284
65MP0010155_abnormal_intestine_physiology1.22210540
66MP0002019_abnormal_tumor_incidence1.21947946
67MP0005375_adipose_tissue_phenotype1.21030859
68MP0002088_abnormal_embryonic_growth/wei1.20835946
69MP0006054_spinal_hemorrhage1.19038243
70MP0004197_abnormal_fetal_growth/weight/1.18971771
71MP0002084_abnormal_developmental_patter1.18703438
72MP0005000_abnormal_immune_tolerance1.18265447
73MP0002405_respiratory_system_inflammati1.18016382
74MP0002086_abnormal_extraembryonic_tissu1.17025478
75MP0002085_abnormal_embryonic_tissue1.15593016
76MP0003787_abnormal_imprinting1.14006591
77MP0008877_abnormal_DNA_methylation1.12922884
78MP0001873_stomach_inflammation1.08015756
79MP0005025_abnormal_response_to1.06516294
80MP0001697_abnormal_embryo_size1.03488728
81MP0000313_abnormal_cell_death1.03109960
82MP0001915_intracranial_hemorrhage1.02695981
83MP0000428_abnormal_craniofacial_morphol1.01677256
84MP0000371_diluted_coat_color1.01600374
85MP0003436_decreased_susceptibility_to1.00150796
86MP0002080_prenatal_lethality0.99336307
87MP0001348_abnormal_lacrimal_gland0.98670348
88MP0002925_abnormal_cardiovascular_devel0.98072570
89MP0005075_abnormal_melanosome_morpholog0.97645937
90MP0004510_myositis0.97332546
91MP0003121_genomic_imprinting0.97018292
92MP0005023_abnormal_wound_healing0.96813442
93MP0002138_abnormal_hepatobiliary_system0.96562145
94MP0003828_pulmonary_edema0.93676646
95MP0001533_abnormal_skeleton_physiology0.93320270
96MP0005464_abnormal_platelet_physiology0.92476007
97MP0003123_paternal_imprinting0.92023939
98MP0005310_abnormal_salivary_gland0.91951272
99MP0001293_anophthalmia0.91821952
100MP0004185_abnormal_adipocyte_glucose0.90914944
101MP0003191_abnormal_cellular_cholesterol0.89976420
102MP0009703_decreased_birth_body0.88930340
103MP0001849_ear_inflammation0.88019409
104MP0003866_abnormal_defecation0.87429180
105MP0000858_altered_metastatic_potential0.86860310
106MP0002796_impaired_skin_barrier0.86116181
107MP0003935_abnormal_craniofacial_develop0.85998319
108MP0005621_abnormal_cell_physiology0.85260949
109MP0002419_abnormal_innate_immunity0.85024703
110MP0002075_abnormal_coat/hair_pigmentati0.84271430
111MP0003786_premature_aging0.84120248
112MP0001853_heart_inflammation0.83867443
113MP0003279_aneurysm0.83605017
114MP0008961_abnormal_basal_metabolism0.83520972
115MP0009672_abnormal_birth_weight0.82878703
116MP0004858_abnormal_nervous_system0.82370976
117MP0010630_abnormal_cardiac_muscle0.80994402
118MP0004947_skin_inflammation0.79493394
119MP0002933_joint_inflammation0.79451446
120MP0002009_preneoplasia0.79275494
121MP0003115_abnormal_respiratory_system0.78980334
122MP0002132_abnormal_respiratory_system0.78946505
123MP0000003_abnormal_adipose_tissue0.78261165
124MP0001845_abnormal_inflammatory_respons0.77651204
125MP0000266_abnormal_heart_morphology0.77009672
126MP0008995_early_reproductive_senescence0.77000565
127MP0004233_abnormal_muscle_weight0.76960750
128MP0002095_abnormal_skin_pigmentation0.76822346
129MP0003091_abnormal_cell_migration0.76705860
130MP0002998_abnormal_bone_remodeling0.76475002
131MP0009115_abnormal_fat_cell0.75313310
132MP0000477_abnormal_intestine_morphology0.74641302

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)4.27612716
2Obstructive sleep apnea (HP:0002870)3.25895710
3Eczematoid dermatitis (HP:0000976)3.01557562
4Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.84130096
5Metaphyseal cupping (HP:0003021)2.83039323
6Supernumerary ribs (HP:0005815)2.77227011
7Volvulus (HP:0002580)2.70596811
8Flat acetabular roof (HP:0003180)2.69069328
9Increased IgE level (HP:0003212)2.64425117
10Hyperacusis (HP:0010780)2.63248778
11Long eyelashes (HP:0000527)2.62562233
12Broad face (HP:0000283)2.60942565
13Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.59600660
14Short 4th metacarpal (HP:0010044)2.59600660
15Prominent nose (HP:0000448)2.54624349
16Rib fusion (HP:0000902)2.49312709
17Supernumerary bones of the axial skeleton (HP:0009144)2.48863575
18Thin bony cortex (HP:0002753)2.47916143
19J-shaped sella turcica (HP:0002680)2.47300989
20Anal stenosis (HP:0002025)2.45291468
21Seborrheic dermatitis (HP:0001051)2.38727139
22Abnormal number of incisors (HP:0011064)2.35708965
23Vertebral arch anomaly (HP:0008438)2.35257304
24Thoracic kyphosis (HP:0002942)2.34960120
25Increased nuchal translucency (HP:0010880)2.32632296
26IgM deficiency (HP:0002850)2.31150185
27Intestinal fistula (HP:0100819)2.30863162
28T lymphocytopenia (HP:0005403)2.29836149
29Recurrent viral infections (HP:0004429)2.25351820
30Deep palmar crease (HP:0006191)2.25245505
31Abnormality of the thoracic spine (HP:0100711)2.22498160
32Ectopic kidney (HP:0000086)2.22174301
33Basal cell carcinoma (HP:0002671)2.21994127
34Abnormality of T cell number (HP:0011839)2.18007122
35Autoimmune thrombocytopenia (HP:0001973)2.17884515
36Recurrent bronchitis (HP:0002837)2.17389487
37Subacute progressive viral hepatitis (HP:0006572)2.11955280
38Recurrent abscess formation (HP:0002722)2.11517232
39Mediastinal lymphadenopathy (HP:0100721)2.11074847
40Abnormality of the distal phalanx of the thumb (HP:0009617)2.08867384
41Gastrointestinal inflammation (HP:0004386)2.08252877
42Acute myeloid leukemia (HP:0004808)2.07481591
43Meningitis (HP:0001287)2.07375847
44Narrow palate (HP:0000189)2.06988186
45Recurrent bacterial skin infections (HP:0005406)2.06916108
46Macroorchidism (HP:0000053)2.06357386
47Urethral obstruction (HP:0000796)2.06259702
48Skin tags (HP:0010609)2.04403642
49Progressive external ophthalmoplegia (HP:0000590)2.04029283
50Myelodysplasia (HP:0002863)2.03879661
51Inflammation of the large intestine (HP:0002037)2.02694203
52Gingivitis (HP:0000230)2.01813186
53Asymmetry of the thorax (HP:0001555)2.00442412
54Thrombocytosis (HP:0001894)1.99549732
55Obstructive lung disease (HP:0006536)1.99148784
56Chronic obstructive pulmonary disease (HP:0006510)1.99148784
57Broad palm (HP:0001169)1.98739643
58Abnormal delayed hypersensitivity skin test (HP:0002963)1.97287153
59Medulloblastoma (HP:0002885)1.97057172
60Trigonocephaly (HP:0000243)1.96011077
61Cerebral aneurysm (HP:0004944)1.95626457
62Reticulocytopenia (HP:0001896)1.95618523
63Gastrointestinal stroma tumor (HP:0100723)1.95560762
64Sparse lateral eyebrow (HP:0005338)1.94662437
6511 pairs of ribs (HP:0000878)1.94532387
66High pitched voice (HP:0001620)1.93389953
67Abnormality of T cells (HP:0002843)1.93120743
68Lip pit (HP:0100267)1.92706046
69Proximal placement of thumb (HP:0009623)1.92699916
70Aplasia/Hypoplasia of the thymus (HP:0010515)1.92655820
71Deformed sella turcica (HP:0002681)1.92364883
72Cellulitis (HP:0100658)1.92260396
73Lymphopenia (HP:0001888)1.92180958
74Neoplasm of the oral cavity (HP:0100649)1.91611446
75Hemorrhage of the eye (HP:0011885)1.91599905
76Recurrent cutaneous fungal infections (HP:0011370)1.91455454
77Chronic mucocutaneous candidiasis (HP:0002728)1.91455454
78Abnormality of cells of the lymphoid lineage (HP:0012140)1.91039989
79Selective tooth agenesis (HP:0001592)1.90764807
80Abnormality of the 4th metacarpal (HP:0010012)1.89198509
81Dislocated radial head (HP:0003083)1.88713549
82Deviation of the thumb (HP:0009603)1.87933591
83Uterine leiomyosarcoma (HP:0002891)1.87113199
84Leiomyosarcoma (HP:0100243)1.87113199
85Recurrent fungal infections (HP:0002841)1.86784870
86Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.86552400
87Deep venous thrombosis (HP:0002625)1.86155910
88Prolonged bleeding time (HP:0003010)1.85740389
89Amaurosis fugax (HP:0100576)1.85385017
90Agammaglobulinemia (HP:0004432)1.85032371
91Gastrointestinal carcinoma (HP:0002672)1.84509042
92Malignant gastrointestinal tract tumors (HP:0006749)1.84509042
93Skull defect (HP:0001362)1.84471195
94Gastrointestinal infarctions (HP:0005244)1.83488067
95Ankyloglossia (HP:0010296)1.82215242
96Ankle contracture (HP:0006466)1.81589423
97Neonatal hypoglycemia (HP:0001998)1.80722816
98Preauricular skin tag (HP:0000384)1.80475315
99Poikiloderma (HP:0001029)1.80213151
100Ulnar bowing (HP:0003031)1.79913499
101Colitis (HP:0002583)1.79803601
102Abnormality of the radial head (HP:0003995)1.78999175
103Shallow orbits (HP:0000586)1.78171357
104Absent frontal sinuses (HP:0002688)1.78028973
105Renovascular hypertension (HP:0100817)1.75262540
106Fatigue (HP:0012378)1.74623968
107Abnormality of macrophages (HP:0004311)1.74409162
108Heterotopia (HP:0002282)1.74197593
109Limited elbow extension (HP:0001377)1.74026464
110Ependymoma (HP:0002888)1.73262975
111Broad thumb (HP:0011304)1.73221605
112Pointed chin (HP:0000307)1.72402588
113Abnormality of the aortic arch (HP:0012303)1.72289280
114Abnormality of the lumbar spine (HP:0100712)1.71825308
115Biconcave vertebral bodies (HP:0004586)1.71202522
116Polygenic inheritance (HP:0010982)1.71041829
117Acute lymphatic leukemia (HP:0006721)1.70833061
118Depressed nasal tip (HP:0000437)1.70759653
119Transitional cell carcinoma of the bladder (HP:0006740)1.70464928
120Flared metaphyses (HP:0003015)1.69720543
121Facial hemangioma (HP:0000329)1.69672353
122Spontaneous hematomas (HP:0007420)1.69583083
123Renal duplication (HP:0000075)1.69538952
124Abnormality of the intervertebral disk (HP:0005108)1.68662296
125Long palpebral fissure (HP:0000637)1.68384657
126Mitral regurgitation (HP:0001653)1.67226779
127Syringomyelia (HP:0003396)1.66865853
128Spinal cord lesions (HP:0100561)1.66865853
129Recurrent gram-negative bacterial infections (HP:0005420)1.66693601
130Viral hepatitis (HP:0006562)1.65647967
131Chromsome breakage (HP:0040012)1.63803195
132Disproportionate tall stature (HP:0001519)1.63744234
133Spondylolisthesis (HP:0003302)1.63686692
134Panhypogammaglobulinemia (HP:0003139)1.63145121
135Microvesicular hepatic steatosis (HP:0001414)1.63065415
136Emphysema (HP:0002097)1.62624951
137Cutis marmorata (HP:0000965)1.62389121
138Segmental peripheral demyelination/remyelination (HP:0003481)1.62273485
139Abnormality of the phalanges of the hallux (HP:0010057)1.62094410
140Sparse scalp hair (HP:0002209)1.61953425
141Aortic aneurysm (HP:0004942)1.60954218
142Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.60870508
143Pallor (HP:0000980)1.60782976
144Bicuspid aortic valve (HP:0001647)1.60447979
145Pustule (HP:0200039)1.60188770
146Low anterior hairline (HP:0000294)1.59733163
147Hematochezia (HP:0002573)1.59563606
148Increased density of long bones (HP:0006392)1.59016359
149Abnormality of the peritoneum (HP:0002585)1.58838999
150Deep philtrum (HP:0002002)1.58643956
151Hypertensive crisis (HP:0100735)1.58604570
152Chest pain (HP:0100749)1.57595650
153Myositis (HP:0100614)1.57479638
154Pseudobulbar signs (HP:0002200)1.56792648
155Papilledema (HP:0001085)1.56415504
156Abnormality of the thymus (HP:0000777)1.55170366
157Recurrent skin infections (HP:0001581)1.55166303
158Cupped ribs (HP:0000887)1.53531705
159Turricephaly (HP:0000262)1.52593996
160Abnormal vertebral ossification (HP:0100569)1.51978796
161Abnormality of reticulocytes (HP:0004312)1.51744296
162Patellar dislocation (HP:0002999)1.51403591
163Hypercortisolism (HP:0001578)1.49354563

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.44326730
2MAP4K13.86115896
3PRPF4B3.16431124
4SMG13.09509984
5MAP3K103.07554267
6BRD42.71672002
7CDC72.59634137
8EEF2K2.45498516
9NEK22.41324498
10RIPK42.17636103
11LATS12.12266374
12PKN22.05285935
13STK101.91627773
14ERN11.65449345
15TRIB31.65041021
16JAK31.62277992
17NME21.62230846
18SIK21.58996634
19CDK41.58010762
20TNK21.53956303
21PIM11.51982858
22TYK21.48871360
23GRK61.35987278
24CDK61.32236932
25BTK1.29285459
26ATR1.26414881
27CAMK1D1.25304088
28ZAP701.24465192
29BLK1.24340609
30MARK31.24266698
31MAP3K131.22024340
32TXK1.19835998
33ICK1.19488669
34STK41.19085349
35CAMK1G1.18008302
36TYRO31.17769803
37CDK71.17579442
38MAP3K141.17376454
39STK31.16651691
40TTN1.16539084
41KIT1.14300837
42CDC42BPA1.13479428
43MAP3K61.12288825
44PTK61.09403017
45MTOR1.07948091
46NLK1.06323845
47TTK1.05736685
48SIK31.04223348
49CHUK1.03396615
50IKBKE1.03304448
51IRAK41.00565158
52RPS6KA40.97786681
53KSR20.97385810
54TGFBR20.95952381
55JAK10.95220966
56CSF1R0.95089525
57ALK0.93575670
58ITK0.93386042
59RPS6KC10.93186213
60RPS6KL10.93186213
61LRRK20.93035766
62CHEK10.92880275
63PAK40.91662356
64PASK0.91627540
65CLK10.91579142
66RIPK10.90076884
67IKBKB0.89288559
68NUAK10.88626759
69SRPK10.88114399
70MKNK20.87730691
71TAOK10.82988500
72CDK90.82976577
73TEC0.82851881
74RPS6KB20.82060421
75TAOK30.81648779
76HCK0.81500873
77MAP3K70.81294464
78FLT30.79277736
79MAPK120.78787037
80WNK10.77365523
81CSK0.77304200
82MAP3K80.75812363
83LCK0.74978912
84CHEK20.74976034
85HIPK20.74606528
86ATM0.73719753
87EPHA30.73656429
88PRKD20.71829787
89RPS6KA60.71169780
90AURKB0.71051528
91TBK10.70720887
92FGFR30.70164111
93RPS6KA20.67962216
94DYRK30.67792575
95BMX0.67359771
96MAPK70.67242300
97MKNK10.67112214
98CDK20.65332816
99FES0.65268788
100MAP3K10.65194608
101MAPK110.64885993
102FGFR40.63785854
103SIK10.63694060
104SYK0.63613728
105PDGFRA0.63452995
106DYRK1B0.61755244
107MAP3K110.61617555
108PRKD30.58576457
109TGFBR10.57696343
110IRAK30.57691798
111PDPK10.57491770
112IRAK20.56254610
113NEK90.56009509
114MATK0.54939173
115PLK10.54508932
116TAOK20.53967679
117EPHB10.53084081
118RET0.52403994
119MAP2K20.52039430
120JAK20.51992620
121WEE10.51831205
122MAP2K60.51805109
123PDGFRB0.50867541
124DMPK0.50341014
125MARK20.49127326
126SGK30.48499178
127PDK10.45933212
128NME10.43119320
129CDK10.42653185
130MAPK10.42584978
131* AKT10.42550370
132MAP2K30.41080619
133YES10.40693678
134MELK0.39781210
135CAMKK10.39295337
136LYN0.39293933

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005112.53440003
2DNA replication_Homo sapiens_hsa030302.27504025
3Primary immunodeficiency_Homo sapiens_hsa053402.21157865
4B cell receptor signaling pathway_Homo sapiens_hsa046622.04578916
5Spliceosome_Homo sapiens_hsa030401.84072541
6NF-kappa B signaling pathway_Homo sapiens_hsa040641.82552173
7Mismatch repair_Homo sapiens_hsa034301.78307824
8Chronic myeloid leukemia_Homo sapiens_hsa052201.72789120
9Herpes simplex infection_Homo sapiens_hsa051681.70614317
10Base excision repair_Homo sapiens_hsa034101.67060797
11mRNA surveillance pathway_Homo sapiens_hsa030151.65836586
12Cell cycle_Homo sapiens_hsa041101.65231659
13Acute myeloid leukemia_Homo sapiens_hsa052211.65188645
14Lysine degradation_Homo sapiens_hsa003101.61075766
15Homologous recombination_Homo sapiens_hsa034401.59576400
16Notch signaling pathway_Homo sapiens_hsa043301.55502933
17Measles_Homo sapiens_hsa051621.51023551
18Transcriptional misregulation in cancer_Homo sapiens_hsa052021.50984153
19Fanconi anemia pathway_Homo sapiens_hsa034601.45269727
20Osteoclast differentiation_Homo sapiens_hsa043801.44898296
21Small cell lung cancer_Homo sapiens_hsa052221.42700090
22RNA transport_Homo sapiens_hsa030131.42568941
23Leishmaniasis_Homo sapiens_hsa051401.42496763
24T cell receptor signaling pathway_Homo sapiens_hsa046601.40026885
25Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.38677328
26Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.34172653
27HTLV-I infection_Homo sapiens_hsa051661.31139830
28Non-homologous end-joining_Homo sapiens_hsa034501.30718573
29MicroRNAs in cancer_Homo sapiens_hsa052061.30611994
30Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.30562157
31Staphylococcus aureus infection_Homo sapiens_hsa051501.24014320
32Antigen processing and presentation_Homo sapiens_hsa046121.20986163
33Hematopoietic cell lineage_Homo sapiens_hsa046401.20634150
34RNA degradation_Homo sapiens_hsa030181.20150559
35ErbB signaling pathway_Homo sapiens_hsa040121.19020725
36Pancreatic cancer_Homo sapiens_hsa052121.18763989
37Bladder cancer_Homo sapiens_hsa052191.18541493
38Choline metabolism in cancer_Homo sapiens_hsa052311.18387709
39Jak-STAT signaling pathway_Homo sapiens_hsa046301.18063294
40Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.17360040
41Non-small cell lung cancer_Homo sapiens_hsa052231.16556918
42Toxoplasmosis_Homo sapiens_hsa051451.13401607
43Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.10911655
44Intestinal immune network for IgA production_Homo sapiens_hsa046721.10549389
45p53 signaling pathway_Homo sapiens_hsa041151.09113870
46Influenza A_Homo sapiens_hsa051641.08965636
47Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.08813386
48Hepatitis B_Homo sapiens_hsa051611.08717497
49Colorectal cancer_Homo sapiens_hsa052101.08611027
50Viral carcinogenesis_Homo sapiens_hsa052031.07070503
51Apoptosis_Homo sapiens_hsa042101.03716687
52Epstein-Barr virus infection_Homo sapiens_hsa051691.03553167
53Basal cell carcinoma_Homo sapiens_hsa052171.03546090
54NOD-like receptor signaling pathway_Homo sapiens_hsa046211.03497722
55Allograft rejection_Homo sapiens_hsa053301.03057288
56Phospholipase D signaling pathway_Homo sapiens_hsa040721.02983286
57Prostate cancer_Homo sapiens_hsa052151.02828440
58Longevity regulating pathway - mammal_Homo sapiens_hsa042111.01946912
59Tuberculosis_Homo sapiens_hsa051521.01656716
60Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.00935619
61Nucleotide excision repair_Homo sapiens_hsa034200.98790823
62Endometrial cancer_Homo sapiens_hsa052130.97981707
63Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.97425166
64Insulin signaling pathway_Homo sapiens_hsa049100.96990218
65RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.96068036
66Platelet activation_Homo sapiens_hsa046110.95412754
67AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.95328163
68Toll-like receptor signaling pathway_Homo sapiens_hsa046200.94461700
69mTOR signaling pathway_Homo sapiens_hsa041500.93651483
70Thyroid hormone signaling pathway_Homo sapiens_hsa049190.92069271
71TNF signaling pathway_Homo sapiens_hsa046680.91531293
72Viral myocarditis_Homo sapiens_hsa054160.91338477
73Leukocyte transendothelial migration_Homo sapiens_hsa046700.89034486
74Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.87747545
75Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.87477333
76GnRH signaling pathway_Homo sapiens_hsa049120.87140473
77Adherens junction_Homo sapiens_hsa045200.86993121
78Proteoglycans in cancer_Homo sapiens_hsa052050.86870197
79Pathways in cancer_Homo sapiens_hsa052000.86664011
80Autoimmune thyroid disease_Homo sapiens_hsa053200.84762154
81Thyroid cancer_Homo sapiens_hsa052160.82832289
82Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.81724013
83Neurotrophin signaling pathway_Homo sapiens_hsa047220.81121254
84Adipocytokine signaling pathway_Homo sapiens_hsa049200.81045414
85Chemokine signaling pathway_Homo sapiens_hsa040620.81012537
86Dorso-ventral axis formation_Homo sapiens_hsa043200.80549170
87Prion diseases_Homo sapiens_hsa050200.79525659
88Graft-versus-host disease_Homo sapiens_hsa053320.79307428
89One carbon pool by folate_Homo sapiens_hsa006700.77103404
90Asthma_Homo sapiens_hsa053100.74236451
91Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.73180500
92Prolactin signaling pathway_Homo sapiens_hsa049170.72818930
93Estrogen signaling pathway_Homo sapiens_hsa049150.72745616
94FoxO signaling pathway_Homo sapiens_hsa040680.72645025
95Sulfur relay system_Homo sapiens_hsa041220.71239403
96Regulation of actin cytoskeleton_Homo sapiens_hsa048100.70486111
97Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.69283357
98Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.69027632
99Sphingolipid signaling pathway_Homo sapiens_hsa040710.68563541
100Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.68131943
101TGF-beta signaling pathway_Homo sapiens_hsa043500.67660863
102Cyanoamino acid metabolism_Homo sapiens_hsa004600.67024126
103Focal adhesion_Homo sapiens_hsa045100.67023547
104Basal transcription factors_Homo sapiens_hsa030220.66770556
105Carbohydrate digestion and absorption_Homo sapiens_hsa049730.65201089
106Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.63538438
107Inositol phosphate metabolism_Homo sapiens_hsa005620.63434287
108AMPK signaling pathway_Homo sapiens_hsa041520.62815372
109VEGF signaling pathway_Homo sapiens_hsa043700.62228626
110Phosphatidylinositol signaling system_Homo sapiens_hsa040700.61338588
111Malaria_Homo sapiens_hsa051440.61019520
112Renal cell carcinoma_Homo sapiens_hsa052110.60191318
113Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.60108245
114HIF-1 signaling pathway_Homo sapiens_hsa040660.59180283
115Wnt signaling pathway_Homo sapiens_hsa043100.58991691
116Shigellosis_Homo sapiens_hsa051310.58875775
117Insulin resistance_Homo sapiens_hsa049310.58786830
118Type I diabetes mellitus_Homo sapiens_hsa049400.57687591
119Hepatitis C_Homo sapiens_hsa051600.57448775
120Hippo signaling pathway_Homo sapiens_hsa043900.56936422
121Ribosome_Homo sapiens_hsa030100.56357476
122Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55302608
123Glioma_Homo sapiens_hsa052140.54865414
124Type II diabetes mellitus_Homo sapiens_hsa049300.54522675
125Rap1 signaling pathway_Homo sapiens_hsa040150.53376577
126MAPK signaling pathway_Homo sapiens_hsa040100.52324567
127Amoebiasis_Homo sapiens_hsa051460.52307925
128Systemic lupus erythematosus_Homo sapiens_hsa053220.50810260
129Central carbon metabolism in cancer_Homo sapiens_hsa052300.50449515

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