ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	acrosome reaction (GO:0007340)	9.94176833
2	fusion of sperm to egg plasma membrane (GO:0007342)	9.27386532
3	response to xenobiotic stimulus (GO:0009410)	8.50800401
4	cysteine metabolic process (GO:0006534)	7.86250967
5	sperm capacitation (GO:0048240)	7.45508839
6	plasma membrane fusion (GO:0045026)	7.31134596
7	chromosome condensation (GO:0030261)	7.18699946
8	response to pheromone (GO:0019236)	7.12108582
9	spermatid development (GO:0007286)	7.07859382
10	DNA packaging (GO:0006323)	7.00849285
11	rRNA methylation (GO:0031167)	6.87546892
12	negative regulation of T cell differentiation in thymus (GO:0033085)	6.82482983
13	spermatid nucleus differentiation (GO:0007289)	6.77787703
14	microtubule depolymerization (GO:0007019)	6.58848650
15	multicellular organism reproduction (GO:0032504)	6.45008696
16	sperm-egg recognition (GO:0035036)	6.39957003
17	response to nitrosative stress (GO:0051409)	6.33046695
18	axonemal dynein complex assembly (GO:0070286)	6.30373026
19	protein polyglutamylation (GO:0018095)	6.23830254
20	rRNA modification (GO:0000154)	6.03448595
21	single strand break repair (GO:0000012)	5.96473710
22	reproduction (GO:0000003)	5.93131568
23	negative regulation of inclusion body assembly (GO:0090084)	5.70596953
24	binding of sperm to zona pellucida (GO:0007339)	5.52881724
25	sexual reproduction (GO:0019953)	5.34601260
26	spermatogenesis (GO:0007283)	5.32129659
27	microtubule polymerization or depolymerization (GO:0031109)	5.31530813
28	male gamete generation (GO:0048232)	5.30697440
29	calcium ion-dependent exocytosis (GO:0017156)	5.21893975
30	L-ascorbic acid metabolic process (GO:0019852)	5.14836445
31	cell-cell recognition (GO:0009988)	5.12990831
32	glutathione biosynthetic process (GO:0006750)	4.90784212
33	centriole replication (GO:0007099)	4.90077529
34	gamete generation (GO:0007276)	4.85183923
35	chromatin silencing (GO:0006342)	4.82237035
36	phosphatidylethanolamine biosynthetic process (GO:0006646)	4.76293243
37	regulation of cilium movement (GO:0003352)	4.66660336
38	nonribosomal peptide biosynthetic process (GO:0019184)	4.57800013
39	positive regulation of T cell apoptotic process (GO:0070234)	4.53036431
40	regulation of T cell differentiation in thymus (GO:0033081)	4.52946933
41	microtubule severing (GO:0051013)	4.47621813
42	cellular ketone body metabolic process (GO:0046950)	4.36347096
43	single fertilization (GO:0007338)	4.36191310
44	establishment of protein localization to Golgi (GO:0072600)	4.35122355
45	positive regulation of T cell differentiation in thymus (GO:0033089)	4.33714051
46	phosphatidylethanolamine metabolic process (GO:0046337)	4.33267869
47	multicellular organismal movement (GO:0050879)	4.27295788
48	musculoskeletal movement (GO:0050881)	4.27295788
49	protein targeting to Golgi (GO:0000042)	4.24619934
50	epithelial cilium movement (GO:0003351)	4.22632540
51	centriole assembly (GO:0098534)	4.15462619
52	nucleus organization (GO:0006997)	4.12904817
53	cilium or flagellum-dependent cell motility (GO:0001539)	4.12351777
54	male meiosis I (GO:0007141)	4.10830482
55	endothelial cell chemotaxis (GO:0035767)	4.06782163
56	motile cilium assembly (GO:0044458)	4.02541846
57	germ cell development (GO:0007281)	3.92586117
58	seminiferous tubule development (GO:0072520)	3.88841568
59	regulation of Rab GTPase activity (GO:0032313)	3.88286473
60	positive regulation of Rab GTPase activity (GO:0032851)	3.88286473
61	multicellular organismal reproductive process (GO:0048609)	3.87184530
62	retrograde transport, vesicle recycling within Golgi (GO:0000301)	3.85993767
63	ketone body metabolic process (GO:1902224)	3.84243808
64	fertilization (GO:0009566)	3.82865888
65	piRNA metabolic process (GO:0034587)	3.74611790
66	heparin biosynthetic process (GO:0030210)	3.71385806
67	heparin metabolic process (GO:0030202)	3.71385806
68	regulation of gamma-delta T cell differentiation (GO:0045586)	3.69542086
69	regulation of inclusion body assembly (GO:0090083)	3.68865902
70	cellular process involved in reproduction in multicellular organism (GO:0022412)	3.67883691
71	negative regulation of Rho protein signal transduction (GO:0035024)	3.67449906
72	regulation of transcription involved in cell fate commitment (GO:0060850)	3.65479777
73	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	3.63018076
74	membrane protein intracellular domain proteolysis (GO:0031293)	3.60384468
75	muscle organ morphogenesis (GO:0048644)	3.59278353
76	S-adenosylmethionine metabolic process (GO:0046500)	3.57761265
77	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.55426721
78	definitive hemopoiesis (GO:0060216)	3.53925852
79	regulation of interleukin-12 biosynthetic process (GO:0045075)	3.53766181
80	regulation of mitochondrial depolarization (GO:0051900)	3.50886681
81	regulation of thymocyte apoptotic process (GO:0070243)	3.50536588
82	nuclear pore complex assembly (GO:0051292)	3.49431779
83	DNA methylation involved in gamete generation (GO:0043046)	3.47782327
84	viral mRNA export from host cell nucleus (GO:0046784)	3.47591554
85	cilium movement (GO:0003341)	3.44133619
86	response to acidic pH (GO:0010447)	3.38352536
87	RNA destabilization (GO:0050779)	3.37680258
88	neurofilament cytoskeleton organization (GO:0060052)	3.35626415
89	organic cation transport (GO:0015695)	3.29123267
90	regulation of microtubule-based movement (GO:0060632)	3.28909547
91	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	3.27596282
92	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	3.27596282
93	positive regulation of mitotic sister chromatid separation (GO:1901970)	3.27596282
94	positive regulation of lymphocyte apoptotic process (GO:0070230)	3.27211105
95	protein localization to Golgi apparatus (GO:0034067)	3.26380136
96	meiosis I (GO:0007127)	3.24926233
97	regulation of centriole replication (GO:0046599)	3.18846922
98	regulation of meiosis I (GO:0060631)	3.18545772
99	peptide biosynthetic process (GO:0043043)	3.17495834
100	sperm motility (GO:0030317)	10.2774936

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	3.03673276
2	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.02832112
3	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.72806150
4	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	2.72806150
5	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.51968189
6	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.47155966
7	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	2.39699578
8	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.24713875
9	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	2.20794698
10	CBP_20019798_ChIP-Seq_JUKART_Human	2.20794698
11	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.19747772
12	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.18762172
13	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	2.17930183
14	ERA_21632823_ChIP-Seq_H3396_Human	2.14573928
15	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	2.12552978
16	FUS_26573619_Chip-Seq_HEK293_Human	2.12046090
17	ELF1_20517297_ChIP-Seq_JURKAT_Human	2.10930239
18	STAT6_21828071_ChIP-Seq_BEAS2B_Human	2.05606031
19	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.98245124
20	RAC3_21632823_ChIP-Seq_H3396_Human	1.90364281
21	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.88574510
22	PHF8_20622854_ChIP-Seq_HELA_Human	1.86504387
23	NANOG_20526341_ChIP-Seq_ESCs_Human	1.83282231
24	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.80791639
25	TAF2_19829295_ChIP-Seq_ESCs_Human	1.79436745
26	BCL6_27268052_Chip-Seq_Bcells_Human	1.77763960
27	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.77473942
28	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.73837708
29	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.71876773
30	MYC_19829295_ChIP-Seq_ESCs_Human	1.69450801
31	DROSHA_22980978_ChIP-Seq_HELA_Human	1.69357047
32	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.68990701
33	ER_23166858_ChIP-Seq_MCF-7_Human	1.61976697
34	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.60471459
35	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.60429563
36	ERG_20517297_ChIP-Seq_VCAP_Human	1.58075775
37	E2F1_20622854_ChIP-Seq_HELA_Human	1.56842143
38	EZH2_22144423_ChIP-Seq_EOC_Human	1.55744695
39	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.54536108
40	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.53711161
41	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.51654301
42	CEBPB_22108803_ChIP-Seq_LS180_Human	1.48916405
43	ZNF274_21170338_ChIP-Seq_K562_Hela	1.47627877
44	BCOR_27268052_Chip-Seq_Bcells_Human	1.47057570
45	CTCF_27219007_Chip-Seq_Bcells_Human	1.47019608
46	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.45550192
47	P300_19829295_ChIP-Seq_ESCs_Human	1.44276632
48	ETV1_20927104_ChIP-Seq_GIST48_Human	1.43555502
49	P300_27268052_Chip-Seq_Bcells_Human	1.43289241
50	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.41997889
51	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.41437537
52	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.39403361
53	P68_20966046_ChIP-Seq_HELA_Human	1.37658169
54	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.37329622
55	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.36503605
56	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.36503605
57	RBPJ_21746931_ChIP-Seq_IB4_Human	1.34666916
58	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.33601118
59	TAF15_26573619_Chip-Seq_HEK293_Human	1.33435585
60	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.33131123
61	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.32921077
62	HOXB7_26014856_ChIP-Seq_BT474_Human	1.32054628
63	SMC4_20622854_ChIP-Seq_HELA_Human	1.31694388
64	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.31263841
65	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.29722045
66	CTCF_20526341_ChIP-Seq_ESCs_Human	1.29282214
67	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	1.29128025
68	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.27529820
69	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	1.27239020
70	AR_25329375_ChIP-Seq_VCAP_Human	1.27162805
71	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.25198629
72	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.25021195
73	CSB_26484114_Chip-Seq_FIBROBLAST_Human	1.23256917
74	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.22644842
75	P53_21459846_ChIP-Seq_SAOS-2_Human	1.22449045
76	SMRT_27268052_Chip-Seq_Bcells_Human	1.22330789
77	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.22149776
78	NFYB_21822215_ChIP-Seq_K562_Human	1.21887137
79	TP63_22573176_ChIP-Seq_HFKS_Human	1.21450659
80	SPI1_20517297_ChIP-Seq_HL60_Human	1.21140309
81	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.20401771
82	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.19154524
83	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.18787432
84	VDR_22108803_ChIP-Seq_LS180_Human	1.18178653
85	OCT4_20526341_ChIP-Seq_ESCs_Human	1.16998414
86	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.15282066
87	PHF8_20622853_ChIP-Seq_HELA_Human	1.12686409
88	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.11150745
89	RUNX1_27514584_Chip-Seq_MCF-7_Human	1.10405226
90	PKCTHETA_26484144_Chip-Seq_BREAST_Human	1.10164898
91	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.09163257
92	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.07938629
93	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.06114703
94	SOX2_22085726_ChIP-Seq_NPCs_Mouse	1.06038338
95	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.05962853
96	RUNX_20019798_ChIP-Seq_JUKART_Human	1.04756487
97	STAT3_23295773_ChIP-Seq_U87_Human	1.03505664
98	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.02200363
99	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.02092548
100	RUNX1_26923725_Chip-Seq_HPCs_Mouse	1.01477106

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005410_abnormal_fertilization	9.78363632
2	MP0005423_abnormal_somatic_nervous	4.60609800
3	MP0005377_hearing/vestibular/ear_phenot	4.36230606
4	MP0003878_abnormal_ear_physiology	4.36230606
5	MP0003698_abnormal_male_reproductive	3.75796672
6	MP0003890_abnormal_embryonic-extraembry	3.30751743
7	MP0001929_abnormal_gametogenesis	3.30179648
8	MP0001348_abnormal_lacrimal_gland	3.26785635
9	MP0005670_abnormal_white_adipose	2.91612165
10	MP0000750_abnormal_muscle_regeneration	2.66999999
11	MP0003646_muscle_fatigue	2.30898096
12	MP0002132_abnormal_respiratory_system	2.04756221
13	MP0008057_abnormal_DNA_replication	2.02006191
14	MP0002161_abnormal_fertility/fecundity	1.99665473
15	MP0001968_abnormal_touch/_nociception	1.99178153
16	MP0004742_abnormal_vestibular_system	1.83096300
17	MP0003718_maternal_effect	1.77397778
18	MP0002210_abnormal_sex_determination	1.76382735
19	MP0003806_abnormal_nucleotide_metabolis	1.65428031
20	MP0002254_reproductive_system_inflammat	1.59638286
21	MP0003436_decreased_susceptibility_to	1.59618873
22	MP0001986_abnormal_taste_sensitivity	1.59157545
23	MP0004134_abnormal_chest_morphology	1.57718312
24	MP0002269_muscular_atrophy	1.55245837
25	MP0002822_catalepsy	1.54394981
26	MP0002138_abnormal_hepatobiliary_system	1.52409550
27	MP0000678_abnormal_parathyroid_gland	1.48044918
28	MP0002735_abnormal_chemical_nociception	1.43767329
29	MP0001145_abnormal_male_reproductive	1.40758640
30	MP0003011_delayed_dark_adaptation	1.35458729
31	MP0000955_abnormal_spinal_cord	1.35102091
32	MP0005310_abnormal_salivary_gland	1.34615305
33	MP0000653_abnormal_sex_gland	1.28972016
34	MP0002229_neurodegeneration	1.26478729
35	MP0002067_abnormal_sensory_capabilities	1.21153485
36	MP0002234_abnormal_pharynx_morphology	1.19440486
37	MP0000685_abnormal_immune_system	1.13960170
38	MP0005647_abnormal_sex_gland	1.08626733
39	MP0010368_abnormal_lymphatic_system	1.07660828
40	MP0003633_abnormal_nervous_system	1.07317498
41	MP0008877_abnormal_DNA_methylation	1.04591344
42	MP0003329_amyloid_beta_deposits	1.01464960
43	MP0003943_abnormal_hepatobiliary_system	1.01227440
44	MP0002249_abnormal_larynx_morphology	0.97173553
45	MP0004142_abnormal_muscle_tone	0.94817633
46	MP0001486_abnormal_startle_reflex	0.93136798
47	MP0001440_abnormal_grooming_behavior	0.91365843
48	MP0001485_abnormal_pinna_reflex	0.89417730
49	MP0000015_abnormal_ear_pigmentation	0.89164477
50	MP0009053_abnormal_anal_canal	0.87306682
51	MP0001835_abnormal_antigen_presentation	0.87237486
52	MP0001765_abnormal_ion_homeostasis	0.85976754
53	MP0002736_abnormal_nociception_after	0.85431501
54	MP0004808_abnormal_hematopoietic_stem	0.83563708
55	MP0003879_abnormal_hair_cell	0.83524103
56	MP0002127_abnormal_cardiovascular_syste	0.82747985
57	MP0002272_abnormal_nervous_system	0.82400546
58	MP0001501_abnormal_sleep_pattern	0.80187153
59	MP0000470_abnormal_stomach_morphology	0.80149138
60	MP0002734_abnormal_mechanical_nocicepti	0.78645230
61	MP0002282_abnormal_trachea_morphology	0.77989656
62	MP0000569_abnormal_digit_pigmentation	0.77380911
63	MP0003631_nervous_system_phenotype	0.76876254
64	MP0005408_hypopigmentation	0.73901455
65	MP0008961_abnormal_basal_metabolism	0.72476857
66	MP0001873_stomach_inflammation	0.71702935
67	MP0000026_abnormal_inner_ear	0.71120822
68	MP0001963_abnormal_hearing_physiology	0.69802184
69	MP0005253_abnormal_eye_physiology	0.69341335
70	MP0001764_abnormal_homeostasis	0.68601675
71	MP0003632_abnormal_nervous_system	0.67062893
72	MP0005379_endocrine/exocrine_gland_phen	0.66210796
73	MP0008875_abnormal_xenobiotic_pharmacok	0.64679004
74	MP0009764_decreased_sensitivity_to	0.63074868
75	MP0002653_abnormal_ependyma_morphology	0.62971000
76	MP0002557_abnormal_social/conspecific_i	0.62601630
77	MP0003763_abnormal_thymus_physiology	0.61393828
78	MP0005551_abnormal_eye_electrophysiolog	0.61169600
79	MP0002405_respiratory_system_inflammati	0.58781786
80	MP0009115_abnormal_fat_cell	0.57964372
81	MP0001533_abnormal_skeleton_physiology	0.57867937
82	MP0002733_abnormal_thermal_nociception	0.57015923
83	MP0000313_abnormal_cell_death	0.56955935
84	MP0003077_abnormal_cell_cycle	0.56850496
85	MP0009785_altered_susceptibility_to	0.54369818
86	MP0002160_abnormal_reproductive_system	0.53413860
87	MP0000762_abnormal_tongue_morphology	0.53091286
88	MP0005636_abnormal_mineral_homeostasis	0.52533853
89	MP0002106_abnormal_muscle_physiology	0.52416773
90	MP0009745_abnormal_behavioral_response	0.52253825
91	MP0004484_altered_response_of	0.52169178
92	MP0000516_abnormal_urinary_system	0.51614225
93	MP0005367_renal/urinary_system_phenotyp	0.51614225
94	MP0004085_abnormal_heartbeat	0.51455611
95	MP0009250_abnormal_appendicular_skeleto	0.50113249
96	MP0001879_abnormal_lymphatic_vessel	0.50009628
97	MP0003936_abnormal_reproductive_system	0.49958438
98	MP0008995_early_reproductive_senescence	0.49832100
99	MP0001970_abnormal_pain_threshold	0.49520496
100	MP0005395_other_phenotype	0.48449581

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Severe visual impairment (HP:0001141)	5.89766927
2	Nasal polyposis (HP:0100582)	5.87459460
3	Chronic hepatic failure (HP:0100626)	5.50527033
4	Dynein arm defect of respiratory motile cilia (HP:0012255)	5.36712468
5	Absent/shortened dynein arms (HP:0200106)	5.36712468
6	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	5.30012062
7	Attenuation of retinal blood vessels (HP:0007843)	5.08340985
8	Abnormality of the nasal mucosa (HP:0000433)	4.93771131
9	Abnormal respiratory motile cilium physiology (HP:0012261)	4.53913643
10	Bony spicule pigmentary retinopathy (HP:0007737)	4.28646441
11	Abnormal rod and cone electroretinograms (HP:0008323)	4.22194406
12	Hyperkalemia (HP:0002153)	4.14894867
13	Amyotrophic lateral sclerosis (HP:0007354)	4.14387955
14	Abnormal respiratory epithelium morphology (HP:0012253)	3.89828314
15	Abnormal respiratory motile cilium morphology (HP:0005938)	3.89828314
16	Abnormal ciliary motility (HP:0012262)	3.88092482
17	Retinal dysplasia (HP:0007973)	3.75641999
18	Abnormality of macular pigmentation (HP:0008002)	3.59849953
19	Stomatitis (HP:0010280)	3.58561303
20	Hypoplasia of the thymus (HP:0000778)	3.56895464
21	Abnormality of DNA repair (HP:0003254)	3.53737065
22	Tubulointerstitial nephritis (HP:0001970)	3.40347097
23	Azoospermia (HP:0000027)	3.35407199
24	Chronic bronchitis (HP:0004469)	3.29591353
25	Acute myeloid leukemia (HP:0004808)	3.15180413
26	Rhinitis (HP:0012384)	3.13304346
27	Infertility (HP:0000789)	3.09526948
28	Nephronophthisis (HP:0000090)	3.08991667
29	Abnormality of the costochondral junction (HP:0000919)	2.99596196
30	Abnormal spermatogenesis (HP:0008669)	2.94943878
31	Cutaneous melanoma (HP:0012056)	2.92598128
32	Asymmetric septal hypertrophy (HP:0001670)	2.91782717
33	Bell-shaped thorax (HP:0001591)	2.90058432
34	Facial shape deformation (HP:0011334)	2.86817407
35	Potter facies (HP:0002009)	2.86817407
36	Hypoplastic ischia (HP:0003175)	2.74859776
37	Male infertility (HP:0003251)	2.72690298
38	Bronchitis (HP:0012387)	2.71499184
39	Amelogenesis imperfecta (HP:0000705)	2.68426031
40	Bronchiectasis (HP:0002110)	2.67986120
41	Molar tooth sign on MRI (HP:0002419)	2.66560845
42	Abnormality of midbrain morphology (HP:0002418)	2.66560845
43	Resting tremor (HP:0002322)	2.63633415
44	Pendular nystagmus (HP:0012043)	2.53326103
45	Chronic sinusitis (HP:0011109)	2.53011669
46	Abnormality of the renal medulla (HP:0100957)	2.51695090
47	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	2.49445910
48	Aplasia/Hypoplasia of the earlobes (HP:0009906)	2.39416228
49	Atrophy/Degeneration involving motor neurons (HP:0007373)	2.38811381
50	Cerebellar dysplasia (HP:0007033)	2.37581367
51	Truncal obesity (HP:0001956)	2.35923398
52	Entropion (HP:0000621)	2.33771680
53	Stage 5 chronic kidney disease (HP:0003774)	2.33371276
54	Recurrent bronchitis (HP:0002837)	2.31560817
55	Abnormality of the epiphysis of the femoral head (HP:0010574)	2.31544836
56	Generalized aminoaciduria (HP:0002909)	2.31387696
57	Thyroiditis (HP:0100646)	2.31366135
58	Metaphyseal dysplasia (HP:0100255)	2.30221321
59	Abnormality of the ischium (HP:0003174)	2.29093023
60	Renal dysplasia (HP:0000110)	2.25054518
61	Pancreatic cysts (HP:0001737)	2.24071303
62	Chronic otitis media (HP:0000389)	2.21477880
63	Severe combined immunodeficiency (HP:0004430)	2.19101691
64	Enlarged epiphyses (HP:0010580)	2.16942211
65	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	2.14833183
66	Cone-rod dystrophy (HP:0000548)	2.14713091
67	Impulsivity (HP:0100710)	2.13034597
68	Abnormality involving the epiphyses of the lower limbs (HP:0006500)	2.12178528
69	Abnormality of femoral epiphyses (HP:0006499)	2.12178528
70	Renovascular hypertension (HP:0100817)	2.12088135
71	Upper limb muscle weakness (HP:0003484)	2.10716383
72	Portal hypertension (HP:0001409)	2.09727844
73	Abnormality of the femoral head (HP:0003368)	2.09362167
74	Abnormality of the aortic arch (HP:0012303)	2.08730022
75	Intellectual disability, moderate (HP:0002342)	2.08120070
76	Decreased central vision (HP:0007663)	2.08039018
77	Flat capital femoral epiphysis (HP:0003370)	2.07249068
78	Abnormality of potassium homeostasis (HP:0011042)	2.05692656
79	Type II lissencephaly (HP:0007260)	2.01651397
80	Inability to walk (HP:0002540)	1.98472524
81	Protuberant abdomen (HP:0001538)	1.95001933
82	Abnormal urine output (HP:0012590)	1.91718751
83	Abnormality of the hepatic vasculature (HP:0006707)	1.91431114
84	Confusion (HP:0001289)	1.90941837
85	Congenital sensorineural hearing impairment (HP:0008527)	1.88523212
86	Optic nerve hypoplasia (HP:0000609)	1.86077894
87	Poikiloderma (HP:0001029)	1.84156211
88	Type I diabetes mellitus (HP:0100651)	1.82536459
89	Unilateral renal agenesis (HP:0000122)	1.81338942
90	Postural instability (HP:0002172)	1.80794167
91	Photophobia (HP:0000613)	1.79845728
92	Bulbous nose (HP:0000414)	1.79001358
93	Supernumerary bones of the axial skeleton (HP:0009144)	1.78196226
94	Abnormality of chloride homeostasis (HP:0011422)	1.74555006
95	Hypoalbuminemia (HP:0003073)	1.73117939
96	Abnormal albumin level (HP:0012116)	1.73117939
97	Abnormality of abdominal situs (HP:0011620)	1.73102569
98	Abdominal situs inversus (HP:0003363)	1.73102569
99	Gingivitis (HP:0000230)	1.72059212
100	Tetany (HP:0001281)	1.71471765

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PLK4	6.01208003
2	PNCK	4.81657810
3	TESK1	4.10937401
4	DDR2	3.67046793
5	LATS1	3.52631225
6	DYRK2	3.45086657
7	AKT3	3.15601639
8	STK38	3.11778541
9	HIPK2	2.86030155
10	NUAK1	2.65616972
11	MAP4K2	2.65355558
12	INSRR	2.55173094
13	TAOK3	2.33920037
14	CAMK1G	2.33319577
15	PLK2	2.24111756
16	NEK6	2.02439289
17	STK38L	1.95335224
18	CDK19	1.88758188
19	BRD4	1.69153517
20	MST4	1.63263023
21	TIE1	1.62070424
22	MAPK15	1.58967375
23	NME1	1.55021360
24	KSR2	1.36547940
25	MST1R	1.29308164
26	PTK2B	1.26431989
27	CDK12	1.15147911
28	MET	1.14982638
29	PDK1	1.14371113
30	BRAF	1.13356839
31	PDPK1	1.12283457
32	IKBKB	1.08104087
33	CHUK	1.06191364
34	MAP3K12	1.06109909
35	ADRBK2	1.01988179
36	VRK2	0.92166853
37	CDK4	0.88705785
38	CDK7	0.85030824
39	ZAK	0.84364919
40	TAF1	0.83326258
41	WNK1	0.82798797
42	DYRK1B	0.79366160
43	MAP3K11	0.77399639
44	OXSR1	0.77217490
45	SGK494	0.75206389
46	SGK223	0.75206389
47	PIK3CG	0.75016312
48	PRKD3	0.67592468
49	ITK	0.64648207
50	CSF1R	0.61143725
51	FRK	0.60150186
52	SRPK1	0.56764589
53	PRKG1	0.56389803
54	PRKAA2	0.51263877
55	MAP3K13	0.50949789
56	GRK7	0.49876894
57	RPS6KA1	0.49796265
58	TAOK2	0.46545388
59	MAP4K1	0.43536134
60	CSNK1A1L	0.40767581
61	STK3	0.40629733
62	MYLK	0.38324408
63	ABL2	0.37028355
64	ROCK1	0.35927951
65	PINK1	0.34652369
66	VRK1	0.34499178
67	MAP3K8	0.33894409
68	CAMK1	0.33882531
69	PAK3	0.32229519
70	MAPKAPK5	0.30137724
71	MAPK14	0.27083249
72	CDK2	0.26565378
73	TXK	0.25055611
74	BMX	0.23659289
75	TYRO3	0.23256036
76	MAP3K7	0.23229258
77	SGK1	0.22224120
78	GSK3B	0.22120722
79	MAPK1	0.21267260
80	TNIK	0.20884029
81	STK39	0.19684454
82	BLK	0.19538290
83	DAPK1	0.19418061
84	CDK1	0.18937663
85	BMPR1B	0.18276290
86	UHMK1	0.18259644
87	BRSK2	0.17871332
88	PRKCG	0.17866426
89	SGK2	0.17354418
90	PAK6	0.17233753
91	GRK5	0.16573689
92	JAK3	0.14743478
93	CHEK1	0.12632041
94	TLK1	0.12623058
95	MUSK	0.12435505
96	ADRBK1	0.12036526
97	MAP3K4	0.11817969
98	PRKCI	0.11615903
99	WNK4	0.11016407
100	GRK1	0.10615554

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	5.83667256
2	Fatty acid biosynthesis_Homo sapiens_hsa00061	5.03386996
3	Olfactory transduction_Homo sapiens_hsa04740	3.11853408
4	Primary immunodeficiency_Homo sapiens_hsa05340	3.06135023
5	Cysteine and methionine metabolism_Homo sapiens_hsa00270	3.02788400
6	Allograft rejection_Homo sapiens_hsa05330	2.18213700
7	Antigen processing and presentation_Homo sapiens_hsa04612	2.17896597
8	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.10321802
9	RNA transport_Homo sapiens_hsa03013	2.10211363
10	Glutathione metabolism_Homo sapiens_hsa00480	1.97148457
11	Cardiac muscle contraction_Homo sapiens_hsa04260	1.77267157
12	Butanoate metabolism_Homo sapiens_hsa00650	1.76340100
13	Taste transduction_Homo sapiens_hsa04742	1.75163319
14	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.73827785
15	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	1.73622368
16	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.57630693
17	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.48570271
18	Selenocompound metabolism_Homo sapiens_hsa00450	1.43297706
19	Type I diabetes mellitus_Homo sapiens_hsa04940	1.40333715
20	Adipocytokine signaling pathway_Homo sapiens_hsa04920	1.39929503
21	Phototransduction_Homo sapiens_hsa04744	1.35117295
22	Regulation of autophagy_Homo sapiens_hsa04140	1.35077340
23	Legionellosis_Homo sapiens_hsa05134	1.33740904
24	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.29074066
25	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.27718371
26	Linoleic acid metabolism_Homo sapiens_hsa00591	1.15754683
27	Type II diabetes mellitus_Homo sapiens_hsa04930	1.13631182
28	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.08325353
29	Graft-versus-host disease_Homo sapiens_hsa05332	1.08111333
30	ABC transporters_Homo sapiens_hsa02010	1.07187932
31	Fatty acid degradation_Homo sapiens_hsa00071	1.06890569
32	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.03529931
33	Salivary secretion_Homo sapiens_hsa04970	1.00993771
34	Caffeine metabolism_Homo sapiens_hsa00232	1.00798761
35	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	1.00353443
36	Purine metabolism_Homo sapiens_hsa00230	0.99669079
37	Asthma_Homo sapiens_hsa05310	0.99025719
38	Fatty acid metabolism_Homo sapiens_hsa01212	0.93420449
39	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.93306616
40	Morphine addiction_Homo sapiens_hsa05032	0.92717393
41	Viral myocarditis_Homo sapiens_hsa05416	0.90191946
42	Protein digestion and absorption_Homo sapiens_hsa04974	0.86574048
43	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.81330404
44	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.79391478
45	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.79039229
46	Nitrogen metabolism_Homo sapiens_hsa00910	0.78305549
47	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.77487345
48	Arginine and proline metabolism_Homo sapiens_hsa00330	0.76579269
49	Huntingtons disease_Homo sapiens_hsa05016	0.76239561
50	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.73111398
51	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.72635652
52	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.71714574
53	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.67993124
54	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.65318018
55	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.63547878
56	Calcium signaling pathway_Homo sapiens_hsa04020	0.63256805
57	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.61050764
58	Nucleotide excision repair_Homo sapiens_hsa03420	0.58997617
59	Serotonergic synapse_Homo sapiens_hsa04726	0.58702885
60	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.57611838
61	Phenylalanine metabolism_Homo sapiens_hsa00360	0.57093669
62	Nicotine addiction_Homo sapiens_hsa05033	0.54248583
63	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.53920344
64	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.53225570
65	Glutamatergic synapse_Homo sapiens_hsa04724	0.52337194
66	Homologous recombination_Homo sapiens_hsa03440	0.51495620
67	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.50966400
68	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.50845098
69	Circadian entrainment_Homo sapiens_hsa04713	0.50844831
70	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.50406152
71	cAMP signaling pathway_Homo sapiens_hsa04024	0.49400724
72	Fanconi anemia pathway_Homo sapiens_hsa03460	0.49117390
73	Retinol metabolism_Homo sapiens_hsa00830	0.48862618
74	MAPK signaling pathway_Homo sapiens_hsa04010	0.46944930
75	Toxoplasmosis_Homo sapiens_hsa05145	0.45518394
76	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.45440864
77	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.44423175
78	Propanoate metabolism_Homo sapiens_hsa00640	0.43860005
79	Peroxisome_Homo sapiens_hsa04146	0.42777667
80	Malaria_Homo sapiens_hsa05144	0.42467333
81	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.42312439
82	Glycerolipid metabolism_Homo sapiens_hsa00561	0.42018040
83	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.41813853
84	Metabolic pathways_Homo sapiens_hsa01100	0.41674678
85	Insulin secretion_Homo sapiens_hsa04911	0.41571561
86	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.37157889
87	Basal transcription factors_Homo sapiens_hsa03022	0.35125317
88	Fat digestion and absorption_Homo sapiens_hsa04975	0.35063135
89	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.34713358
90	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.34617727
91	Mineral absorption_Homo sapiens_hsa04978	0.33558648
92	Viral carcinogenesis_Homo sapiens_hsa05203	0.32847286
93	Chemical carcinogenesis_Homo sapiens_hsa05204	0.32720878
94	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.32316267
95	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.31003389
96	Gastric acid secretion_Homo sapiens_hsa04971	0.29386338
97	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.28615214
98	mRNA surveillance pathway_Homo sapiens_hsa03015	0.27803718
99	Mismatch repair_Homo sapiens_hsa03430	0.27412503
100	Endocytosis_Homo sapiens_hsa04144	0.25062964

CLK2P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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