CLK3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein belonging to the serine/threonine type protein kinase family. This protein is a nuclear dual-specificity kinase that regulates the intranuclear distribution of the serine/arginine-rich (SR) family of splicing factors. Two transcript variants encoding different isoforms have been found for this gene. Related pseudogenes are located on chromosomes 1 and 9. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1polyketide metabolic process (GO:0030638)4.89480272
2doxorubicin metabolic process (GO:0044598)4.89480272
3daunorubicin metabolic process (GO:0044597)4.89480272
4protein localization to kinetochore (GO:0034501)4.73643235
5interferon-gamma production (GO:0032609)4.47644139
6mitotic sister chromatid segregation (GO:0000070)4.30778217
7protein localization to chromosome, centromeric region (GO:0071459)4.18821489
8modulation by virus of host process (GO:0019054)4.18607062
9regulation of gamma-delta T cell differentiation (GO:0045586)3.90683313
10positive regulation of gamma-delta T cell activation (GO:0046645)3.86374648
11negative regulation of cell killing (GO:0031342)3.84957687
12negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.84957687
13regulation of nuclear cell cycle DNA replication (GO:0033262)3.77805241
14sister chromatid segregation (GO:0000819)3.74531530
15regulation of telomere maintenance via telomerase (GO:0032210)3.73525068
16modulation by symbiont of host cellular process (GO:0044068)3.67847583
17negative regulation of telomere maintenance (GO:0032205)3.61863948
18negative regulation of erythrocyte differentiation (GO:0045647)3.57003649
19regulation of gamma-delta T cell activation (GO:0046643)3.56620102
20phosphatidylethanolamine biosynthetic process (GO:0006646)3.53817553
21positive regulation of granulocyte differentiation (GO:0030854)3.40928773
22detection of bacterium (GO:0016045)3.37905010
23response to peptidoglycan (GO:0032494)3.34301134
24regulation of response to osmotic stress (GO:0047484)3.31971220
25hepatocyte apoptotic process (GO:0097284)3.31447235
26negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.29737025
27detection of other organism (GO:0098543)3.28666044
28DNA replication checkpoint (GO:0000076)3.28112898
29negative regulation of cell cycle G2/M phase transition (GO:1902750)3.24233473
30phosphatidylethanolamine metabolic process (GO:0046337)3.17511054
31positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.14714482
32mitotic chromosome condensation (GO:0007076)3.12069212
33negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.09486034
34positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.07022934
35cellular response to exogenous dsRNA (GO:0071360)3.06738034
36histone H3-K9 modification (GO:0061647)3.05663515
37response to muramyl dipeptide (GO:0032495)3.05399431
38sperm motility (GO:0030317)3.05361480
39thymic T cell selection (GO:0045061)3.05241766
40cellular extravasation (GO:0045123)3.04965222
41positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.00855703
42regulation of interleukin-2 biosynthetic process (GO:0045076)3.00365648
43histone H4-K8 acetylation (GO:0043982)2.99133502
44histone H4-K5 acetylation (GO:0043981)2.99133502
45fusion of sperm to egg plasma membrane (GO:0007342)2.98956253
46protoporphyrinogen IX metabolic process (GO:0046501)2.97508425
47regulation of mammary gland epithelial cell proliferation (GO:0033599)2.96816084
48maintenance of protein location in nucleus (GO:0051457)2.96705891
49histone H3-K4 trimethylation (GO:0080182)2.96155262
50B cell receptor signaling pathway (GO:0050853)2.95525036
51cellular response to virus (GO:0098586)2.95419554
52regulation of granulocyte differentiation (GO:0030852)2.95303045
53chromatin assembly (GO:0031497)2.95274613
54germinal center formation (GO:0002467)2.94375149
55modulation by symbiont of host defense response (GO:0052031)2.93442333
56modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.93442333
57modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.93442333
58positive regulation by organism of defense response of other organism involved in symbiotic interact2.93442333
59modulation by symbiont of host immune response (GO:0052553)2.93442333
60positive regulation by symbiont of host defense response (GO:0052509)2.93442333
61macrophage activation involved in immune response (GO:0002281)2.92613595
62negative T cell selection (GO:0043383)2.92117723
63protoporphyrinogen IX biosynthetic process (GO:0006782)2.88756613
64positive regulation of T cell mediated cytotoxicity (GO:0001916)2.88258048
65NAD biosynthetic process (GO:0009435)2.86391929
66antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.86062194
67antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.86062194
68negative regulation of T cell mediated immunity (GO:0002710)2.85540372
69endothelial tube morphogenesis (GO:0061154)2.85211793
70morphogenesis of an endothelium (GO:0003159)2.85211793
71neutrophil activation (GO:0042119)2.82664093
72rRNA methylation (GO:0031167)2.82514594
73regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.82176054
74aminoglycoside antibiotic metabolic process (GO:0030647)2.81925225
75positive regulation of DNA-dependent DNA replication (GO:2000105)2.81916301
76regulation of Rab GTPase activity (GO:0032313)2.81784034
77positive regulation of Rab GTPase activity (GO:0032851)2.81784034
78mannose metabolic process (GO:0006013)2.81529104
79positive regulation of protein deacetylation (GO:0090312)2.80297182
80regulation of T cell mediated cytotoxicity (GO:0001914)2.80134593
81positive regulation of interleukin-2 production (GO:0032743)2.80008243
82negative regulation of lymphocyte mediated immunity (GO:0002707)2.79560411
83heterochromatin organization (GO:0070828)2.78846558
84T cell migration (GO:0072678)2.77523967
85negative regulation of phagocytosis (GO:0050765)2.76991973
86regulation of necroptotic process (GO:0060544)2.76466292
87negative regulation of interleukin-8 production (GO:0032717)2.76298588
88activated T cell proliferation (GO:0050798)2.76049159
89regulation of mast cell degranulation (GO:0043304)2.75709425
90histone H3-K36 demethylation (GO:0070544)2.75202553
91response to type I interferon (GO:0034340)2.74876895
92regulation of mast cell activation involved in immune response (GO:0033006)2.74662893
93histone H3-K9 methylation (GO:0051567)2.74098620
94mast cell activation (GO:0045576)2.74037643
95acrosome reaction (GO:0007340)2.72824623
96regulation of B cell differentiation (GO:0045577)2.72502470
97rRNA transcription (GO:0009303)2.70560914
98DNA replication-dependent nucleosome organization (GO:0034723)2.70506852
99DNA replication-dependent nucleosome assembly (GO:0006335)2.70506852
100T cell selection (GO:0045058)2.70026921
101NIK/NF-kappaB signaling (GO:0038061)2.69794678
102negative regulation of interleukin-12 production (GO:0032695)2.69548660
103antigen processing and presentation of endogenous antigen (GO:0019883)2.69496370
104DNA unwinding involved in DNA replication (GO:0006268)2.69145180
105positive regulation of B cell differentiation (GO:0045579)2.69052881
106negative regulation of epidermis development (GO:0045683)2.68624547
107megakaryocyte development (GO:0035855)2.68014110
108multicellular organism reproduction (GO:0032504)2.67786266
109positive T cell selection (GO:0043368)2.67508698
110intracellular estrogen receptor signaling pathway (GO:0030520)2.67394084
111V(D)J recombination (GO:0033151)2.67128879
112establishment of protein localization to Golgi (GO:0072600)2.66993137
113protein localization to chromosome (GO:0034502)2.66940086
114negative regulation of necroptotic process (GO:0060546)2.66666537
115regulation of mast cell activation (GO:0033003)2.66508624
116negative regulation of interleukin-6 production (GO:0032715)2.65606140
117RNA destabilization (GO:0050779)2.65259877
1183-UTR-mediated mRNA stabilization (GO:0070935)2.65056504
119antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.64816594
120myeloid cell activation involved in immune response (GO:0002275)2.63436745
121leukocyte degranulation (GO:0043299)2.63257271
122type I interferon signaling pathway (GO:0060337)2.62287019
123cellular response to type I interferon (GO:0071357)2.62287019
124rRNA modification (GO:0000154)2.62196251
125positive regulation of CREB transcription factor activity (GO:0032793)2.61429658
126negative regulation of leukocyte mediated immunity (GO:0002704)2.61198395
127DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.60778300
128neutrophil activation involved in immune response (GO:0002283)2.60728989
129mature B cell differentiation involved in immune response (GO:0002313)2.59955237
130granulocyte activation (GO:0036230)2.59288314
131positive regulation of isotype switching (GO:0045830)2.59150474
132response to protozoan (GO:0001562)2.57777064
133negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.57255828
134cilium or flagellum-dependent cell motility (GO:0001539)2.55868445
135DNA damage response, signal transduction resulting in transcription (GO:0042772)2.55857185
136leukocyte aggregation (GO:0070486)2.55840507
137regulation of B cell receptor signaling pathway (GO:0050855)2.55632629
138negative regulation of telomerase activity (GO:0051974)2.55317612
139defense response to protozoan (GO:0042832)2.55299323
140regulation of translation in response to stress (GO:0043555)2.54830473
141regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.53879704
142detection of external biotic stimulus (GO:0098581)2.53865192
143cell wall macromolecule metabolic process (GO:0044036)2.53583480
144formation of translation preinitiation complex (GO:0001731)2.53152870
145positive regulation of defense response to virus by host (GO:0002230)2.52526315
146negative regulation of granulocyte differentiation (GO:0030853)2.51087394
147negative regulation of cAMP-mediated signaling (GO:0043951)2.50908173
148positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.50885640
149regulation of interferon-beta biosynthetic process (GO:0045357)2.50377714
150heme biosynthetic process (GO:0006783)2.50066496
151mitotic metaphase plate congression (GO:0007080)2.49712956
152establishment of endothelial barrier (GO:0061028)2.49620011
153mucosal-associated lymphoid tissue development (GO:0048537)2.49496596
154Peyers patch development (GO:0048541)2.49496596
155definitive hemopoiesis (GO:0060216)2.49270322
156neutrophil mediated immunity (GO:0002446)2.49244478
157pore complex assembly (GO:0046931)2.48802128
158negative regulation of gene expression, epigenetic (GO:0045814)2.48336257
159oxygen transport (GO:0015671)2.48201159
160regulation of interleukin-12 biosynthetic process (GO:0045075)2.48163955
161histone H4-K16 acetylation (GO:0043984)2.47511882
162chromosome condensation (GO:0030261)2.46207808
163intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)2.46195981
164meiotic chromosome segregation (GO:0045132)2.46006901
165positive regulation of histone deacetylation (GO:0031065)2.44840760
166positive thymic T cell selection (GO:0045059)2.43681311
167negative thymic T cell selection (GO:0045060)2.42120600
168regulation of thymocyte apoptotic process (GO:0070243)2.41727693
169attachment of spindle microtubules to kinetochore (GO:0008608)2.40193851
170regulation of G0 to G1 transition (GO:0070316)2.40114427
171regulation of MHC class I biosynthetic process (GO:0045343)2.38465478
172DNA deamination (GO:0045006)2.38448531
173DNA duplex unwinding (GO:0032508)2.36823570
174mitotic nuclear envelope disassembly (GO:0007077)2.36371643
175immunoglobulin mediated immune response (GO:0016064)2.36367101
176histone H4-K12 acetylation (GO:0043983)2.35916221
177DNA geometric change (GO:0032392)2.35257393
178modulation by virus of host morphology or physiology (GO:0019048)2.33983268

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.96338713
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.72567843
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.69584973
4MYC_22102868_ChIP-Seq_BL_Human2.93491475
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.91003237
6E2F4_17652178_ChIP-ChIP_JURKAT_Human2.80567082
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.62186604
8* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.55149173
9RUNX_20019798_ChIP-Seq_JUKART_Human2.49211334
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.46661813
11TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.29530715
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.21208351
13SCL_19346495_ChIP-Seq_HPC-7_Human2.14205819
14STAT6_21828071_ChIP-Seq_BEAS2B_Human2.14171778
15* GATA1_19941826_ChIP-Seq_K562_Human2.14001483
16VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.13288461
17STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.12038667
18KDM2B_26808549_Chip-Seq_DND41_Human1.99842131
19TP63_19390658_ChIP-ChIP_HaCaT_Human1.97602739
20SPI1_23127762_ChIP-Seq_K562_Human1.93064356
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.92884254
22SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.91216178
23IRF8_22096565_ChIP-ChIP_GC-B_Human1.87739370
24P68_20966046_ChIP-Seq_HELA_Human1.85569676
25SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.83606102
26* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.82836429
27* GATA1_19941827_ChIP-Seq_MEL_Mouse1.81629336
28* VDR_21846776_ChIP-Seq_THP-1_Human1.77247124
29LXR_22292898_ChIP-Seq_THP-1_Human1.73486575
30VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.70001514
31* MYB_26560356_Chip-Seq_TH2_Human1.69747752
32GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.68717942
33* GATA3_27048872_Chip-Seq_THYMUS_Human1.67863748
34GATA1_22025678_ChIP-Seq_K562_Human1.67679602
35MAF_26560356_Chip-Seq_TH1_Human1.67123188
36CIITA_25753668_ChIP-Seq_RAJI_Human1.65832059
37IRF8_21731497_ChIP-ChIP_J774_Mouse1.65694726
38KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.65468860
39KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.65468860
40KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.65468860
41RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.65394712
42ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.64102665
43SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.64075687
44MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.59746089
45* TCF7_22412390_ChIP-Seq_EML_Mouse1.57411445
46DROSHA_22980978_ChIP-Seq_HELA_Human1.55555938
47GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.54313065
48FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.53867794
49SPI1_23547873_ChIP-Seq_NB4_Human1.53086064
50STAT4_19710469_ChIP-ChIP_TH1__Mouse1.52351916
51* MYB_26560356_Chip-Seq_TH1_Human1.51733576
52PHF8_20622854_ChIP-Seq_HELA_Human1.50646241
53* UTX_26944678_Chip-Seq_JUKART_Human1.49960444
54E2F1_20622854_ChIP-Seq_HELA_Human1.49906404
55MYC_18555785_ChIP-Seq_MESCs_Mouse1.45783991
56FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.43565685
57RUNX1_22412390_ChIP-Seq_EML_Mouse1.42320166
58SMC4_20622854_ChIP-Seq_HELA_Human1.41897601
59* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.40773326
60P300_27268052_Chip-Seq_Bcells_Human1.40728813
61EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.40088975
62CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.39913962
63E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.39784651
64SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.39703314
65* GATA2_19941826_ChIP-Seq_K562_Human1.37565416
66CTCF_27219007_Chip-Seq_ERYTHROID_Human1.36982122
67ERA_21632823_ChIP-Seq_H3396_Human1.36411516
68EST1_17652178_ChIP-ChIP_JURKAT_Human1.35910864
69MYB_21317192_ChIP-Seq_ERMYB_Mouse1.35773690
70LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.33595725
71VDR_24787735_ChIP-Seq_THP-1_Human1.33532379
72GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.30688968
73TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.30488382
74FOXP3_21729870_ChIP-Seq_TREG_Human1.30463881
75MYC_18358816_ChIP-ChIP_MESCs_Mouse1.30242177
76RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.28819325
77* VDR_23849224_ChIP-Seq_CD4+_Human1.28508702
78YY1_22570637_ChIP-Seq_MALME-3M_Human1.28252648
79* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.26827295
80THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.26409456
81* GATA3_26560356_Chip-Seq_TH2_Human1.26408698
82RAC3_21632823_ChIP-Seq_H3396_Human1.25865128
83CTCF_21964334_ChIP-Seq_BJAB-B_Human1.25528656
84KDM2B_26808549_Chip-Seq_JURKAT_Human1.24834841
85SA1_27219007_Chip-Seq_ERYTHROID_Human1.24201770
86SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.23735956
87NOTCH1_21737748_ChIP-Seq_TLL_Human1.22832123
88IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.22554674
89KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.21848451
90MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.21273221
91XRN2_22483619_ChIP-Seq_HELA_Human1.20064554
92SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.19199089
93* MAF_26560356_Chip-Seq_TH2_Human1.18851050
94* ELK3_25401928_ChIP-Seq_HUVEC_Human1.18751294
95CREB1_15753290_ChIP-ChIP_HEK293T_Human1.18543857
96* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.17674185
97ELF1_17652178_ChIP-ChIP_JURKAT_Human1.17205764
98BRD4_27068464_Chip-Seq_AML-cells_Mouse1.16482276
99NANOG_18555785_ChIP-Seq_MESCs_Mouse1.15125863
100PKCTHETA_26484144_Chip-Seq_BREAST_Human1.14826487
101MYC_19079543_ChIP-ChIP_MESCs_Mouse1.14742092
102JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.12713585
103ELF1_20517297_ChIP-Seq_JURKAT_Human1.12352754
104NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.12337039
105MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.11911604
106* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.11788364
107* GABP_19822575_ChIP-Seq_HepG2_Human1.11129218
108RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10758463
109TP63_22573176_ChIP-Seq_HFKS_Human1.09509704
110SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.08995402
111ETS1_20019798_ChIP-Seq_JURKAT_Human1.08856492
112STAT3_1855785_ChIP-Seq_MESCs_Mouse1.08154881
113* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.08024731
114E2F1_21310950_ChIP-Seq_MCF-7_Human1.08012010
115IRF8_27001747_Chip-Seq_BMDM_Mouse1.07219941
116PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06958012
117OCT4_20526341_ChIP-Seq_ESCs_Human1.06910852
118* NCOR1_26117541_ChIP-Seq_K562_Human1.06385802
119TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05827540
120CREB1_26743006_Chip-Seq_LNCaP_Human1.04969485
121CTCF_21964334_Chip-Seq_Bcells_Human1.04848025
122TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.04154989
123CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.04019139
124LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.03887782
125EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.03832474
126* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.03657596
127* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.03546561
128CTCF_20526341_ChIP-Seq_ESCs_Human1.03491008
129NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.03467906
130RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.02207629
131* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.01660016
132BCOR_27268052_Chip-Seq_Bcells_Human1.01599001
133SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.01399281
134BCL6_27268052_Chip-Seq_Bcells_Human1.01084873
135KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.00751239
136CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.00737377
137KDM2B_26808549_Chip-Seq_SUP-B15_Human1.00686875
138SA1_27219007_Chip-Seq_Bcells_Human1.00539390
139NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.99934693
140ERG_20887958_ChIP-Seq_HPC-7_Mouse0.99373140
141HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.99371840
142NANOG_20526341_ChIP-Seq_ESCs_Human0.99321026
143RUNX1_27514584_Chip-Seq_MCF-7_Human0.99183950
144OCT4_19829295_ChIP-Seq_ESCs_Human0.99149987
145POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.98894996
146* VDR_24763502_ChIP-Seq_THP-1_Human0.98421199
147PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97463932
148PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97356480
149* HIF1A_21447827_ChIP-Seq_MCF-7_Human0.97168376
150MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.96883946
151CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.96745564
152STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.95910416
153* HOXB4_20404135_ChIP-ChIP_EML_Mouse0.95575050
154GABP_17652178_ChIP-ChIP_JURKAT_Human0.95017131
155TFEB_21752829_ChIP-Seq_HELA_Human0.94997445

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002396_abnormal_hematopoietic_system3.01284690
2MP0005410_abnormal_fertilization2.98884598
3MP0001835_abnormal_antigen_presentation2.79758351
4MP0005671_abnormal_response_to2.74605953
5MP0008057_abnormal_DNA_replication2.73619798
6MP0003763_abnormal_thymus_physiology2.69717295
7MP0009785_altered_susceptibility_to2.59142678
8MP0003077_abnormal_cell_cycle2.42822002
9MP0000685_abnormal_immune_system2.39722763
10MP0003111_abnormal_nucleus_morphology2.38196595
11MP0002138_abnormal_hepatobiliary_system2.34963662
12MP0004957_abnormal_blastocyst_morpholog2.33816279
13MP0010094_abnormal_chromosome_stability2.31958140
14MP0005083_abnormal_biliary_tract2.31327155
15MP0003693_abnormal_embryo_hatching2.24835271
16MP0002398_abnormal_bone_marrow2.24372431
17MP0001873_stomach_inflammation2.23266269
18MP0003656_abnormal_erythrocyte_physiolo2.22272611
19MP0002132_abnormal_respiratory_system2.21940017
20MP0006082_CNS_inflammation2.17826060
21MP0001800_abnormal_humoral_immune2.11799031
22MP0005075_abnormal_melanosome_morpholog2.06160895
23MP0005000_abnormal_immune_tolerance2.02678239
24MP0003172_abnormal_lysosome_physiology2.00621067
25MP0003646_muscle_fatigue2.00579216
26MP0009333_abnormal_splenocyte_physiolog1.97702771
27MP0000703_abnormal_thymus_morphology1.96955790
28MP0002405_respiratory_system_inflammati1.95804624
29MP0000689_abnormal_spleen_morphology1.94504845
30MP0002722_abnormal_immune_system1.93017037
31MP0004808_abnormal_hematopoietic_stem1.91174547
32MP0002420_abnormal_adaptive_immunity1.88526771
33MP0001819_abnormal_immune_cell1.86643714
34MP0003436_decreased_susceptibility_to1.85570903
35MP0005025_abnormal_response_to1.83549036
36MP0002723_abnormal_immune_serum1.83405278
37MP0005387_immune_system_phenotype1.83349275
38MP0001790_abnormal_immune_system1.83349275
39MP0002452_abnormal_antigen_presenting1.83239720
40MP0000490_abnormal_crypts_of1.83234334
41MP0000716_abnormal_immune_system1.83166979
42MP0003011_delayed_dark_adaptation1.81506952
43MP0010352_gastrointestinal_tract_polyps1.80142721
44MP0002429_abnormal_blood_cell1.75602177
45MP0004381_abnormal_hair_follicle1.74688935
46MP0005670_abnormal_white_adipose1.71982443
47MP0004264_abnormal_extraembryonic_tissu1.71824901
48MP0005397_hematopoietic_system_phenotyp1.67616175
49MP0001545_abnormal_hematopoietic_system1.67616175
50MP0009278_abnormal_bone_marrow1.58754076
51MP0008007_abnormal_cellular_replicative1.58373998
52MP0005394_taste/olfaction_phenotype1.54430069
53MP0005499_abnormal_olfactory_system1.54430069
54MP0002148_abnormal_hypersensitivity_rea1.53687159
55MP0010155_abnormal_intestine_physiology1.50280256
56MP0001986_abnormal_taste_sensitivity1.49399131
57MP0006292_abnormal_olfactory_placode1.48020829
58MP0004130_abnormal_muscle_cell1.47596912
59MP0004947_skin_inflammation1.46689131
60MP0005377_hearing/vestibular/ear_phenot1.44214666
61MP0003878_abnormal_ear_physiology1.44214666
62MP0001533_abnormal_skeleton_physiology1.39543218
63MP0003866_abnormal_defecation1.36170418
64MP0000858_altered_metastatic_potential1.35125790
65MP0002254_reproductive_system_inflammat1.33841587
66MP0002419_abnormal_innate_immunity1.32474403
67MP0003045_fibrosis1.31384567
68MP0002019_abnormal_tumor_incidence1.30941509
69MP0000313_abnormal_cell_death1.27800742
70MP0002009_preneoplasia1.27322645
71MP0008995_early_reproductive_senescence1.25728458
72MP0000350_abnormal_cell_proliferation1.24089789
73MP0008961_abnormal_basal_metabolism1.23978784
74MP0008058_abnormal_DNA_repair1.22340214
75MP0001853_heart_inflammation1.22059180
76MP0001849_ear_inflammation1.21951983
77MP0005076_abnormal_cell_differentiation1.21365483
78MP0001348_abnormal_lacrimal_gland1.15292027
79MP0003698_abnormal_male_reproductive1.11560571
80MP0003448_altered_tumor_morphology1.10877312
81MP0006035_abnormal_mitochondrial_morpho1.10757845
82MP0001845_abnormal_inflammatory_respons1.10443504
83MP0002653_abnormal_ependyma_morphology1.09605028
84MP0005464_abnormal_platelet_physiology1.09472427
85MP0009115_abnormal_fat_cell1.08925452
86MP0002006_tumorigenesis1.07549909
87MP0002166_altered_tumor_susceptibility1.07031022
88MP0003890_abnormal_embryonic-extraembry1.06339000
89MP0002933_joint_inflammation1.06036233
90MP0005380_embryogenesis_phenotype1.03144622
91MP0001672_abnormal_embryogenesis/_devel1.03144622
92MP0003984_embryonic_growth_retardation1.02441739
93MP0002088_abnormal_embryonic_growth/wei1.02082085
94MP0005310_abnormal_salivary_gland0.97150001
95MP0003183_abnormal_peptide_metabolism0.97132652
96MP0001929_abnormal_gametogenesis0.96375024
97MP0004858_abnormal_nervous_system0.94107863
98MP0003121_genomic_imprinting0.89370468
99MP0000343_altered_response_to0.86517967
100MP0003300_gastrointestinal_ulcer0.86514077
101MP0003303_peritoneal_inflammation0.85361407
102MP0005666_abnormal_adipose_tissue0.84815284
103MP0005167_abnormal_blood-brain_barrier0.83417899
104MP0008789_abnormal_olfactory_epithelium0.83328904
105MP0002127_abnormal_cardiovascular_syste0.83203416
106MP0003787_abnormal_imprinting0.83111786
107MP0001730_embryonic_growth_arrest0.82494836
108MP0009764_decreased_sensitivity_to0.82402004
109MP0004147_increased_porphyrin_level0.82265075
110MP0002086_abnormal_extraembryonic_tissu0.82088100
111MP0003705_abnormal_hypodermis_morpholog0.81769158
112MP0002095_abnormal_skin_pigmentation0.81716904
113MP0001663_abnormal_digestive_system0.81549158
114MP0004510_myositis0.80520907
115MP0003186_abnormal_redox_activity0.80206142
116MP0004185_abnormal_adipocyte_glucose0.80138079
117MP0001765_abnormal_ion_homeostasis0.80039069
118MP0009840_abnormal_foam_cell0.79990655
119MP0001243_abnormal_dermal_layer0.78921142
120MP0008469_abnormal_protein_level0.76977750
121MP0000465_gastrointestinal_hemorrhage0.75658018
122MP0003828_pulmonary_edema0.75250464
123MP0002080_prenatal_lethality0.74952207
124MP0003724_increased_susceptibility_to0.74751366
125MP0005174_abnormal_tail_pigmentation0.74409600
126MP0005375_adipose_tissue_phenotype0.74325806
127MP0000678_abnormal_parathyroid_gland0.72570485
128MP0000003_abnormal_adipose_tissue0.72434919
129MP0002332_abnormal_exercise_endurance0.71347417
130MP0000358_abnormal_cell_content/0.70461896
131MP0000371_diluted_coat_color0.70113182
132MP0005257_abnormal_intraocular_pressure0.70038154
133MP0008877_abnormal_DNA_methylation0.69369283
134MP0000015_abnormal_ear_pigmentation0.67896725
135MP0010307_abnormal_tumor_latency0.67807958
136MP0005334_abnormal_fat_pad0.67466976
137MP0005058_abnormal_lysosome_morphology0.66741532
138MP0008932_abnormal_embryonic_tissue0.66237117
139MP0002998_abnormal_bone_remodeling0.64095854
140MP0009765_abnormal_xenobiotic_induced0.63833508
141MP0005451_abnormal_body_composition0.63664071
142MP0002928_abnormal_bile_duct0.63608224
143MP0002249_abnormal_larynx_morphology0.63323632
144MP0000609_abnormal_liver_physiology0.62984621
145MP0000470_abnormal_stomach_morphology0.62159580
146MP0002168_other_aberrant_phenotype0.61624282
147MP0008260_abnormal_autophagy0.60725564
148MP0000249_abnormal_blood_vessel0.54636311
149MP0005390_skeleton_phenotype0.54136447

Predicted human phenotypes

RankGene SetZ-score
1Combined immunodeficiency (HP:0005387)5.02109061
2Hypochromic microcytic anemia (HP:0004840)4.50504184
3Panhypogammaglobulinemia (HP:0003139)4.25351446
4T lymphocytopenia (HP:0005403)4.16550820
5Abnormality of T cell number (HP:0011839)4.04606973
6Abnormality of the heme biosynthetic pathway (HP:0010472)4.02469770
7B lymphocytopenia (HP:0010976)4.01566937
8Abnormality of B cell number (HP:0010975)4.01566937
9Severe combined immunodeficiency (HP:0004430)3.81836789
10Recurrent viral infections (HP:0004429)3.78854127
11Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.75250322
12Nasal polyposis (HP:0100582)3.68261841
13Optic neuritis (HP:0100653)3.60474649
14Retrobulbar optic neuritis (HP:0100654)3.60474649
15Multiple enchondromatosis (HP:0005701)3.56569854
16Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.48074538
17Increased neuronal autofluorescent lipopigment (HP:0002074)3.46018238
18Stomatitis (HP:0010280)3.45518513
19Bilateral microphthalmos (HP:0007633)3.45089168
20Attenuation of retinal blood vessels (HP:0007843)3.42699074
21Elevated erythrocyte sedimentation rate (HP:0003565)3.42320813
22Eosinophilia (HP:0001880)3.40371088
23Abnormal delayed hypersensitivity skin test (HP:0002963)3.31136660
24Chromosomal breakage induced by crosslinking agents (HP:0003221)3.29732453
25Severe visual impairment (HP:0001141)3.23368744
26Abnormality of the nasal mucosa (HP:0000433)3.20954024
27Hypoplasia of the thymus (HP:0000778)3.11838204
28Increased cerebral lipofuscin (HP:0011813)3.11603784
29Gastrointestinal infarctions (HP:0005244)3.10657785
30Myositis (HP:0100614)3.07366270
31Thyroiditis (HP:0100646)3.07320340
32Abnormality of T cells (HP:0002843)3.03829425
33Chromsome breakage (HP:0040012)3.03628998
34Recurrent fungal infections (HP:0002841)3.03317291
35Hypochromic anemia (HP:0001931)3.01049324
36Granulocytopenia (HP:0001913)2.99769024
37Genetic anticipation (HP:0003743)2.94904758
38Abnormality of macrophages (HP:0004311)2.87834078
39Chronic obstructive pulmonary disease (HP:0006510)2.72571899
40Obstructive lung disease (HP:0006536)2.72571899
41Abnormality of eosinophils (HP:0001879)2.64794777
42Clumsiness (HP:0002312)2.62337012
43Encephalitis (HP:0002383)2.60050524
44Abnormality of the fingertips (HP:0001211)2.57333002
45Leukocytosis (HP:0001974)2.57205561
46Pendular nystagmus (HP:0012043)2.54203520
47Keratoconjunctivitis (HP:0001096)2.53417270
48Recurrent bronchitis (HP:0002837)2.53084993
49IgG deficiency (HP:0004315)2.52933048
50Recurrent skin infections (HP:0001581)2.50652056
51Reduced antithrombin III activity (HP:0001976)2.47416042
52Keratoconjunctivitis sicca (HP:0001097)2.46429204
53Orchitis (HP:0100796)2.45630938
54Myelodysplasia (HP:0002863)2.45603604
55Broad palm (HP:0001169)2.44141962
56Chronic otitis media (HP:0000389)2.43304152
57Gingivitis (HP:0000230)2.42307229
58Hemoptysis (HP:0002105)2.40643535
59Colitis (HP:0002583)2.38433297
60Inflammation of the large intestine (HP:0002037)2.37171435
61Abnormality of the lower motor neuron (HP:0002366)2.36993285
62Increased IgE level (HP:0003212)2.36475893
63Rib fusion (HP:0000902)2.35878391
64IgM deficiency (HP:0002850)2.35876456
65Meckel diverticulum (HP:0002245)2.35224750
66Recurrent abscess formation (HP:0002722)2.34636394
67Microcytic anemia (HP:0001935)2.32715124
68Pulmonary infiltrates (HP:0002113)2.32515729
69Gastrointestinal inflammation (HP:0004386)2.32078710
70Hepatoblastoma (HP:0002884)2.31043441
71Microretrognathia (HP:0000308)2.30665230
72Bony spicule pigmentary retinopathy (HP:0007737)2.29910882
73Cellulitis (HP:0100658)2.26562088
74Abnormality of the ileum (HP:0001549)2.26472072
75Abnormality of transition element cation homeostasis (HP:0011030)2.25639446
76Nephroblastoma (Wilms tumor) (HP:0002667)2.25540264
77Abnormality of DNA repair (HP:0003254)2.23775342
78Eczematoid dermatitis (HP:0000976)2.22347113
79Recurrent gram-negative bacterial infections (HP:0005420)2.21134500
80Petechiae (HP:0000967)2.20697449
81Abnormality of the intervertebral disk (HP:0005108)2.20674215
82Spontaneous hematomas (HP:0007420)2.17270567
83Aplastic anemia (HP:0001915)2.14270685
84Reticulocytosis (HP:0001923)2.13422359
85Epistaxis (HP:0000421)2.13087912
86Aplasia/Hypoplasia of the uvula (HP:0010293)2.12109609
87Abnormality of the columella (HP:0009929)2.11433013
88Pustule (HP:0200039)2.11210084
89Hypoproteinemia (HP:0003075)2.11113830
90Intestinal fistula (HP:0100819)2.11055122
91Abnormality of iron homeostasis (HP:0011031)2.09340722
92Increased IgM level (HP:0003496)2.07310505
93Paralysis (HP:0003470)2.07288467
94Rhabdomyosarcoma (HP:0002859)2.06765790
95Lymphoma (HP:0002665)2.06419458
96Abnormal lung lobation (HP:0002101)2.06380588
97Poikilocytosis (HP:0004447)2.05412067
98Autoimmune thrombocytopenia (HP:0001973)2.03424321
99Embryonal renal neoplasm (HP:0011794)2.02792509
100Recurrent bacterial skin infections (HP:0005406)2.02457230
101Stomach cancer (HP:0012126)2.02212001
102Ependymoma (HP:0002888)2.00369969
103Abnormal rod and cone electroretinograms (HP:0008323)2.00043124
104Progressive cerebellar ataxia (HP:0002073)1.99383805
105Congenital stationary night blindness (HP:0007642)1.98645956
106Short 5th finger (HP:0009237)1.98168477
107Agammaglobulinemia (HP:0004432)1.97743123
108Preauricular skin tag (HP:0000384)1.96165689
109Polycythemia (HP:0001901)1.95442964
110Increased serum ferritin (HP:0003281)1.95174261
111Hypertensive crisis (HP:0100735)1.94456605
112Small intestinal stenosis (HP:0012848)1.94246731
113Duodenal stenosis (HP:0100867)1.94246731
114Arterial thrombosis (HP:0004420)1.93084747
115Neoplasm of striated muscle (HP:0009728)1.92588804
116Chronic hepatic failure (HP:0100626)1.92203813
117Aplasia/Hypoplasia of the thymus (HP:0010515)1.92017633
118Meningitis (HP:0001287)1.91666004
119Abnormality of the pleura (HP:0002103)1.91601573
120Abnormality of the nasal septum (HP:0000419)1.91263241
121Mesomelia (HP:0003027)1.88982278
122Bone marrow hypocellularity (HP:0005528)1.88431663
123Hypoplasia of the fovea (HP:0007750)1.88384757
124Aplasia/Hypoplasia of the fovea (HP:0008060)1.88384757
125Abnormality of the preputium (HP:0100587)1.88024428
126Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.87837959
127Truncal obesity (HP:0001956)1.87488480
128Type I transferrin isoform profile (HP:0003642)1.87193899
129Prostate neoplasm (HP:0100787)1.86095955
130Abnormality of chromosome segregation (HP:0002916)1.85608672
131Tented upper lip vermilion (HP:0010804)1.84577774
132Abnormality of T cell physiology (HP:0011840)1.84327770
133Autoimmune hemolytic anemia (HP:0001890)1.83753248
134Acute hepatic failure (HP:0006554)1.80994513
135Skin tags (HP:0010609)1.80796588
136Generalized hypotonia (HP:0001290)1.79756870
137Rectal fistula (HP:0100590)1.79637907
138Rectovaginal fistula (HP:0000143)1.79637907
139Trismus (HP:0000211)1.79086524
140Hypoplastic ischia (HP:0003175)1.78773956
141Asymmetric septal hypertrophy (HP:0001670)1.77867231
142Cheilitis (HP:0100825)1.76817310
143Abnormality of reticulocytes (HP:0004312)1.75499441
144Thrombocytosis (HP:0001894)1.73290584
145Mediastinal lymphadenopathy (HP:0100721)1.73261515
146Chronic mucocutaneous candidiasis (HP:0002728)1.73072840
147Recurrent cutaneous fungal infections (HP:0011370)1.73072840
148Vasculitis (HP:0002633)1.72674917
149Urticaria (HP:0001025)1.70536600
150Anorexia (HP:0002039)1.69776791
151Keratitis (HP:0000491)1.69059861
152Prolonged bleeding time (HP:0003010)1.68161900
153Patellar aplasia (HP:0006443)1.67059015
154Sloping forehead (HP:0000340)1.67039221
155Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.65826417
156Short 1st metacarpal (HP:0010034)1.65826417
157Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.65825681
158Chest pain (HP:0100749)1.64759270
159Partial duplication of thumb phalanx (HP:0009944)1.64577723
160Increased nuchal translucency (HP:0010880)1.64273534
161Hyperkalemia (HP:0002153)1.63413606
162Abnormality of mucopolysaccharide metabolism (HP:0011020)1.62985047
163Abnormality of glycosaminoglycan metabolism (HP:0004371)1.62985047
164Ectopic kidney (HP:0000086)1.62308290

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.68803619
2MAP4K13.38501625
3GRK63.31195195
4ERN13.20292849
5STK102.84368406
6RIPK42.73686950
7MAP3K102.73199587
8CSF1R2.67802957
9TXK2.34824838
10FRK2.26745588
11BUB12.13586037
12TAOK32.06714089
13GRK51.98241740
14TNK21.94540967
15MAPK71.88461101
16ADRBK21.70972334
17TGFBR21.66717093
18MAP3K141.65232934
19FES1.63026829
20PIM21.59891789
21MAP3K111.58075940
22ZAP701.55975535
23RIPK11.55289140
24ITK1.50113363
25MAPK151.42694337
26NEK21.42105254
27TLK11.40537414
28TTK1.39609670
29TBK11.35690308
30KIT1.34441974
31GRK11.33542463
32CAMK1D1.33156333
33INSRR1.33134934
34EEF2K1.32671191
35MAP3K131.32124834
36AKT31.29264576
37CDC71.25903433
38TYK21.24454197
39IKBKB1.21908271
40BLK1.16806877
41CSK1.15824682
42PDK11.14779462
43MAPK111.13203671
44MATK1.12307309
45PAK41.09752855
46BTK1.09173375
47SYK1.08464781
48PLK11.08349013
49JAK31.07836725
50IKBKE1.05883748
51CDK71.05482706
52PIM11.04931249
53BRSK11.04073105
54CHUK1.02323152
55RPS6KA61.02119814
56MAP3K31.02026445
57PDPK11.01270236
58BRD41.00759426
59CAMK1G0.99908486
60PLK40.99279251
61KDR0.98256581
62STK380.98253917
63FLT30.92323893
64IRAK10.91907034
65MAP2K20.91659465
66ICK0.90579464
67STK40.89492631
68ACVR1B0.88594295
69HCK0.86167643
70RPS6KL10.85092295
71RPS6KC10.85092295
72PRKD20.85063915
73BMPR1B0.84150767
74TESK20.83245492
75MOS0.82959436
76LCK0.82548948
77MAP3K70.82496898
78SIK30.82081796
79HIPK20.80935583
80DYRK30.80572516
81SIK10.80526469
82PRKG20.80328754
83JAK20.79150891
84PIK3CG0.76593532
85WEE10.76021813
86BRSK20.75681138
87TAOK20.75103410
88CAMK40.74508961
89MAP3K10.74429460
90AURKB0.74196241
91DYRK1B0.73523996
92CHEK20.73453694
93RPS6KB20.73020968
94PRKAA20.71785266
95ATR0.71756056
96* CHEK10.68323789
97RPS6KA40.68056724
98GRK70.67513018
99JAK10.66649973
100FGFR30.65249869
101WNK10.63629719
102MAP2K30.63167962
103CDK40.62606951
104IRAK30.62513518
105CDC42BPA0.62370939
106CLK10.62067062
107YES10.60779081
108EPHB10.60237539
109RPS6KA20.60019664
110AKT20.59898454
111MELK0.59662248
112PTK2B0.58994026
113SIK20.58671503
114EIF2AK10.58591419
115MTOR0.58526852
116MARK30.58170220
117IRAK40.57830497
118EIF2AK20.57797477
119MAPKAPK20.57035468
120TEC0.56724654
121STK160.55295122
122LYN0.53230158
123TAOK10.52882544
124TRPM70.51482571
125SGK20.51448608
126LRRK20.51293860
127SGK30.50803951
128PRPF4B0.50210248
129MARK20.49473971
130PTK60.49118815
131STK110.48256798
132MAP3K80.48186747
133MAPK120.47986808
134MAPK130.46916788
135TYRO30.46435239
136EPHA30.46315645
137NLK0.44797875
138SRPK10.44703998
139MAPK40.44528908
140IRAK20.44390705
141MUSK0.43982060
142CDK90.43911012
143MAPK80.43697740
144MAP2K60.43529581
145PKN20.43126195
146ZAK0.42779339
147PRKCQ0.40126157
148FGFR40.36951252
149TRIB30.36671631
150TGFBR10.36411592
151CDK20.35910532

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.68647289
2DNA replication_Homo sapiens_hsa030302.82512970
3NF-kappa B signaling pathway_Homo sapiens_hsa040642.29561866
4Base excision repair_Homo sapiens_hsa034102.21060609
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.12741535
6RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.94116969
7Allograft rejection_Homo sapiens_hsa053301.91117602
8Herpes simplex infection_Homo sapiens_hsa051681.86921452
9Homologous recombination_Homo sapiens_hsa034401.86895179
10Leishmaniasis_Homo sapiens_hsa051401.84450761
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.84379130
12Intestinal immune network for IgA production_Homo sapiens_hsa046721.83328277
13Antigen processing and presentation_Homo sapiens_hsa046121.83282928
14Hematopoietic cell lineage_Homo sapiens_hsa046401.83155037
15Cell cycle_Homo sapiens_hsa041101.77799022
16Measles_Homo sapiens_hsa051621.77670567
17Graft-versus-host disease_Homo sapiens_hsa053321.75900435
18Mismatch repair_Homo sapiens_hsa034301.72641638
19T cell receptor signaling pathway_Homo sapiens_hsa046601.72389132
20Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.64041416
21Non-homologous end-joining_Homo sapiens_hsa034501.60538435
22Vitamin B6 metabolism_Homo sapiens_hsa007501.57555613
23Spliceosome_Homo sapiens_hsa030401.56812547
24Fanconi anemia pathway_Homo sapiens_hsa034601.55559678
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.52285323
26RNA transport_Homo sapiens_hsa030131.48920713
27RNA degradation_Homo sapiens_hsa030181.44761890
28Apoptosis_Homo sapiens_hsa042101.44594668
29B cell receptor signaling pathway_Homo sapiens_hsa046621.43755953
30Legionellosis_Homo sapiens_hsa051341.43495807
31Proteasome_Homo sapiens_hsa030501.41384821
32Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.34414582
33Acute myeloid leukemia_Homo sapiens_hsa052211.33810397
34Jak-STAT signaling pathway_Homo sapiens_hsa046301.26346706
35Adipocytokine signaling pathway_Homo sapiens_hsa049201.25565646
36Malaria_Homo sapiens_hsa051441.24910446
37Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.24884435
38mRNA surveillance pathway_Homo sapiens_hsa030151.22318371
39ABC transporters_Homo sapiens_hsa020101.20629872
40Fructose and mannose metabolism_Homo sapiens_hsa000511.19925625
41Type II diabetes mellitus_Homo sapiens_hsa049301.16650922
42Toll-like receptor signaling pathway_Homo sapiens_hsa046201.15634286
43Osteoclast differentiation_Homo sapiens_hsa043801.15368803
44Influenza A_Homo sapiens_hsa051641.15176291
45Glycerophospholipid metabolism_Homo sapiens_hsa005641.15163853
46p53 signaling pathway_Homo sapiens_hsa041151.15129095
47Transcriptional misregulation in cancer_Homo sapiens_hsa052021.12660320
48Toxoplasmosis_Homo sapiens_hsa051451.09358484
49VEGF signaling pathway_Homo sapiens_hsa043701.06214362
50Leukocyte transendothelial migration_Homo sapiens_hsa046701.03953358
51Nucleotide excision repair_Homo sapiens_hsa034201.03588980
52Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.02970459
53Dorso-ventral axis formation_Homo sapiens_hsa043201.02939003
54Viral carcinogenesis_Homo sapiens_hsa052031.02525342
55Epstein-Barr virus infection_Homo sapiens_hsa051691.01358148
56HTLV-I infection_Homo sapiens_hsa051661.00055456
57Small cell lung cancer_Homo sapiens_hsa052220.99715957
58Chronic myeloid leukemia_Homo sapiens_hsa052200.98093799
59NOD-like receptor signaling pathway_Homo sapiens_hsa046210.97149523
60Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.95169987
61Thyroid cancer_Homo sapiens_hsa052160.94074367
62TNF signaling pathway_Homo sapiens_hsa046680.93223787
63FoxO signaling pathway_Homo sapiens_hsa040680.92942226
64Hepatitis B_Homo sapiens_hsa051610.92359255
65Galactose metabolism_Homo sapiens_hsa000520.92305671
66Pancreatic cancer_Homo sapiens_hsa052120.91862322
67Prolactin signaling pathway_Homo sapiens_hsa049170.88895805
68Hepatitis C_Homo sapiens_hsa051600.88819266
69Carbohydrate digestion and absorption_Homo sapiens_hsa049730.88775775
70Type I diabetes mellitus_Homo sapiens_hsa049400.88398236
71Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.88227636
72Notch signaling pathway_Homo sapiens_hsa043300.86525363
73Fatty acid biosynthesis_Homo sapiens_hsa000610.85599538
74Ribosome_Homo sapiens_hsa030100.85016045
75Insulin resistance_Homo sapiens_hsa049310.84738865
76Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.84100742
77Platelet activation_Homo sapiens_hsa046110.83202925
78Longevity regulating pathway - mammal_Homo sapiens_hsa042110.79725242
79Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.79342198
80African trypanosomiasis_Homo sapiens_hsa051430.78532002
81Tuberculosis_Homo sapiens_hsa051520.78446871
82Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.78128784
83Inositol phosphate metabolism_Homo sapiens_hsa005620.77849750
84Phosphatidylinositol signaling system_Homo sapiens_hsa040700.77129023
85RNA polymerase_Homo sapiens_hsa030200.76700602
86Choline metabolism in cancer_Homo sapiens_hsa052310.76602849
87Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.75388838
88Lysosome_Homo sapiens_hsa041420.73165200
89Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.71863560
90MAPK signaling pathway_Homo sapiens_hsa040100.68927295
91Pentose phosphate pathway_Homo sapiens_hsa000300.67494012
92Pyrimidine metabolism_Homo sapiens_hsa002400.66813776
93Arachidonic acid metabolism_Homo sapiens_hsa005900.66496610
94Shigellosis_Homo sapiens_hsa051310.64915861
95Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.64348642
96Basal transcription factors_Homo sapiens_hsa030220.63569975
97Chemokine signaling pathway_Homo sapiens_hsa040620.62764973
98Lysine degradation_Homo sapiens_hsa003100.62519915
99Autoimmune thyroid disease_Homo sapiens_hsa053200.62493805
100Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.62375436
101Viral myocarditis_Homo sapiens_hsa054160.62048183
102Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.61949818
103Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.61358701
104Phospholipase D signaling pathway_Homo sapiens_hsa040720.61154165
105One carbon pool by folate_Homo sapiens_hsa006700.61028382
106alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.60623854
107Other glycan degradation_Homo sapiens_hsa005110.60565650
108Systemic lupus erythematosus_Homo sapiens_hsa053220.59778129
109Rheumatoid arthritis_Homo sapiens_hsa053230.58901250
110Non-small cell lung cancer_Homo sapiens_hsa052230.58167128
111Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.56550195
112Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.55044914
113Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.54920835
114Nitrogen metabolism_Homo sapiens_hsa009100.54865135
115Pertussis_Homo sapiens_hsa051330.53604710
116Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.53151006
117Asthma_Homo sapiens_hsa053100.52889153
118Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.52532724
119MicroRNAs in cancer_Homo sapiens_hsa052060.51878698
120Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.50566515
121Olfactory transduction_Homo sapiens_hsa047400.50553723
122Regulation of autophagy_Homo sapiens_hsa041400.50130012
123Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.49819187
124HIF-1 signaling pathway_Homo sapiens_hsa040660.49499619
125Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.49204380
126Colorectal cancer_Homo sapiens_hsa052100.47771010
127Sphingolipid signaling pathway_Homo sapiens_hsa040710.47571548
128Endocytosis_Homo sapiens_hsa041440.47416878
129Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.47247597
130Prostate cancer_Homo sapiens_hsa052150.45383705
131Pathways in cancer_Homo sapiens_hsa052000.44764530
132Ether lipid metabolism_Homo sapiens_hsa005650.44177954
133Linoleic acid metabolism_Homo sapiens_hsa005910.44143724
134mTOR signaling pathway_Homo sapiens_hsa041500.43912092
135Glycosaminoglycan degradation_Homo sapiens_hsa005310.42855201
136Salmonella infection_Homo sapiens_hsa051320.42017866
137AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.34578567
138Staphylococcus aureus infection_Homo sapiens_hsa051500.31891088
139Neurotrophin signaling pathway_Homo sapiens_hsa047220.30816193

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