CLK3P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of female gonad development (GO:2000194)7.53245833
2regulation of DNA methylation (GO:0044030)7.35012880
3piRNA metabolic process (GO:0034587)7.28410405
4regulation of histone H3-K9 methylation (GO:0051570)6.79425453
5regulation of meiosis I (GO:0060631)6.41663605
6DNA methylation involved in gamete generation (GO:0043046)6.11278678
7positive regulation of histone H3-K4 methylation (GO:0051571)6.08663028
8pyrimidine deoxyribonucleotide catabolic process (GO:0009223)5.78338990
9regulation of acrosome reaction (GO:0060046)5.56667779
10meiotic cell cycle (GO:0051321)5.46562030
11thrombin receptor signaling pathway (GO:0070493)5.18535944
12retinal cone cell development (GO:0046549)5.10420326
13pyrimidine deoxyribonucleotide metabolic process (GO:0009219)4.98998893
14multicellular organism reproduction (GO:0032504)4.95286446
15positive regulation of gastrulation (GO:2000543)4.91486127
16oocyte development (GO:0048599)4.87173689
17pyrimidine nucleotide catabolic process (GO:0006244)4.73374185
18somatic diversification of immune receptors via somatic mutation (GO:0002566)4.69228847
19somatic hypermutation of immunoglobulin genes (GO:0016446)4.69228847
20protein neddylation (GO:0045116)4.63002568
21relaxation of smooth muscle (GO:0044557)4.61241072
22negative regulation of histone methylation (GO:0031061)4.60305369
23female gamete generation (GO:0007292)4.56774864
24primitive streak formation (GO:0090009)4.55513901
25centriole replication (GO:0007099)4.52203561
26regulation of steroid hormone secretion (GO:2000831)4.50678114
27protein kinase C signaling (GO:0070528)4.48172267
28positive regulation of endothelial cell differentiation (GO:0045603)4.43272912
29negative regulation of reproductive process (GO:2000242)4.27957341
30phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)4.17008270
31positive regulation of histone methylation (GO:0031062)4.03152427
32regulation of cell maturation (GO:1903429)3.95880115
33regulation of histone H3-K4 methylation (GO:0051569)3.77701745
34gene silencing by RNA (GO:0031047)3.71249390
35epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.69594837
36regulation of helicase activity (GO:0051095)3.65560434
37male meiosis (GO:0007140)3.64417395
38regulation of hypersensitivity (GO:0002883)3.59140370
39deoxyribonucleotide catabolic process (GO:0009264)3.58796619
40microtubule depolymerization (GO:0007019)3.56663842
41determination of adult lifespan (GO:0008340)3.53191638
42synaptonemal complex assembly (GO:0007130)3.48111482
43sequestering of actin monomers (GO:0042989)3.37332846
44deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.35805010
45somite rostral/caudal axis specification (GO:0032525)3.33244943
46DNA methylation (GO:0006306)3.30820213
47DNA alkylation (GO:0006305)3.30820213
48negative regulation of norepinephrine secretion (GO:0010700)3.30817537
49mismatch repair (GO:0006298)3.29504360
50aggressive behavior (GO:0002118)3.29411279
51positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.29003997
52dopamine biosynthetic process (GO:0042416)3.27620984
53deoxyribose phosphate catabolic process (GO:0046386)3.24349809
54negative regulation of execution phase of apoptosis (GO:1900118)3.23638640
55reciprocal DNA recombination (GO:0035825)3.21690301
56reciprocal meiotic recombination (GO:0007131)3.21690301
57regulation of female receptivity (GO:0045924)3.17730629
58synaptonemal complex organization (GO:0070193)3.15660758
59purinergic nucleotide receptor signaling pathway (GO:0035590)3.14850589
60positive regulation of hormone biosynthetic process (GO:0046886)3.12944531
61reproduction (GO:0000003)3.11616731
62regulation of dopamine metabolic process (GO:0042053)3.08188787
63regulation of catecholamine metabolic process (GO:0042069)3.08188787
64positive regulation of humoral immune response (GO:0002922)3.07537452
65male meiosis I (GO:0007141)3.07243377
66epithelial cilium movement (GO:0003351)3.06407769
67centriole assembly (GO:0098534)3.05908570
68meiosis I (GO:0007127)3.04144168
69female mating behavior (GO:0060180)3.03164555
70negative regulation of DNA recombination (GO:0045910)2.98614401
71glycine transport (GO:0015816)2.96003885
72fertilization (GO:0009566)2.94706519
73organelle membrane fusion (GO:0090174)2.94691503
74regulation of corticosteroid hormone secretion (GO:2000846)2.94597417
75fatty acid elongation (GO:0030497)2.94262263
76positive regulation of reproductive process (GO:2000243)2.93619682
77somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.93313972
78isotype switching (GO:0045190)2.93313972
79somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.93313972
80citrulline biosynthetic process (GO:0019240)2.89316608
81regulation of endothelial cell differentiation (GO:0045601)2.88705020
82chromosome organization involved in meiosis (GO:0070192)2.88450763
83neuron fate determination (GO:0048664)2.87968542
84regulation of steroid hormone biosynthetic process (GO:0090030)2.87352757
85synapsis (GO:0007129)2.86268522
86L-amino acid import (GO:0043092)2.84689385
87regulation of histone methylation (GO:0031060)2.80211876
88negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.79915343
89cilium movement (GO:0003341)2.77283016
90interkinetic nuclear migration (GO:0022027)2.75206360
91regulation of meiosis (GO:0040020)2.74964478
92negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.74900566
93meiotic cell cycle process (GO:1903046)2.74781831
94long-chain fatty acid biosynthetic process (GO:0042759)2.73742525
95ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.71869396
96DNA methylation or demethylation (GO:0044728)2.70475524
97regulation of chromatin silencing (GO:0031935)2.67165013
98microtubule severing (GO:0051013)2.66725011
99neutrophil activation involved in immune response (GO:0002283)2.65528185
100regulation of calcium ion-dependent exocytosis (GO:0017158)2.65263207

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.59267060
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.31844078
3GBX2_23144817_ChIP-Seq_PC3_Human2.92578077
4PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.77890367
5SCL_19346495_ChIP-Seq_HPC-7_Human2.46094353
6STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.42539033
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.37002304
8BP1_19119308_ChIP-ChIP_Hs578T_Human2.15499327
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.06668364
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.04545988
11EZH2_22144423_ChIP-Seq_EOC_Human12.5997922
12IRF1_19129219_ChIP-ChIP_H3396_Human1.98657596
13SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.98636393
14POU3F2_20337985_ChIP-ChIP_501MEL_Human1.76670548
15MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.74394417
16EWS_26573619_Chip-Seq_HEK293_Human1.72660347
17HTT_18923047_ChIP-ChIP_STHdh_Human1.71645167
18LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.71633447
19UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.66385717
20IGF1R_20145208_ChIP-Seq_DFB_Human1.63032544
21TAF15_26573619_Chip-Seq_HEK293_Human1.48915418
22ELK4_26923725_Chip-Seq_MESODERM_Mouse1.40771684
23BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.40551917
24RNF2_27304074_Chip-Seq_NSC_Mouse1.38708149
25AR_25329375_ChIP-Seq_VCAP_Human1.37493289
26SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.36909279
27EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.34472137
28ZNF274_21170338_ChIP-Seq_K562_Hela1.33408933
29TP63_19390658_ChIP-ChIP_HaCaT_Human1.32089236
30PRDM14_20953172_ChIP-Seq_ESCs_Human1.30744774
31GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.30483683
32SMAD4_21799915_ChIP-Seq_A2780_Human1.30416211
33KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.26229908
34KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.26229908
35KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.26229908
36TAL1_26923725_Chip-Seq_HPCs_Mouse1.24766555
37TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24055956
38TCF4_23295773_ChIP-Seq_U87_Human1.23957751
39P300_19829295_ChIP-Seq_ESCs_Human1.23891083
40KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.20175361
41ER_23166858_ChIP-Seq_MCF-7_Human1.19087703
42NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.17660387
43MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.17327211
44IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.17223666
45CBP_20019798_ChIP-Seq_JUKART_Human1.17223666
46NANOG_20526341_ChIP-Seq_ESCs_Human1.16925771
47SALL4_22934838_ChIP-ChIP_CD34+_Human1.14182373
48CTBP2_25329375_ChIP-Seq_LNCAP_Human1.10569099
49CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.08001843
50TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07327519
51TP53_22573176_ChIP-Seq_HFKS_Human1.05519779
52SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05498766
53SMAD4_21741376_ChIP-Seq_EPCs_Human1.05282812
54GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.04234130
55GATA3_21878914_ChIP-Seq_MCF-7_Human1.03979362
56GATA1_19941827_ChIP-Seq_MEL86_Mouse1.02996566
57BMI1_23680149_ChIP-Seq_NPCS_Mouse1.02814710
58CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.01674855
59AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.00989149
60GATA1_19941826_ChIP-Seq_K562_Human1.00360733
61CTBP1_25329375_ChIP-Seq_LNCAP_Human1.00292903
62RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.99355096
63SOX2_19829295_ChIP-Seq_ESCs_Human0.99218487
64NANOG_19829295_ChIP-Seq_ESCs_Human0.99218487
65MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.98120460
66CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98101441
67GATA1_26923725_Chip-Seq_HPCs_Mouse0.97684346
68HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.96514097
69STAT3_23295773_ChIP-Seq_U87_Human0.96453838
70RUNX2_22187159_ChIP-Seq_PCA_Human0.93618761
71AR_20517297_ChIP-Seq_VCAP_Human0.93427968
72SMRT_27268052_Chip-Seq_Bcells_Human0.93256234
73REST_21632747_ChIP-Seq_MESCs_Mouse0.92574154
74ERG_20517297_ChIP-Seq_VCAP_Human0.92092479
75TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90980643
76POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.90980643
77PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.90911054
78FOXA1_21572438_ChIP-Seq_LNCaP_Human0.89603610
79FOXA1_27270436_Chip-Seq_PROSTATE_Human0.89401023
80FOXA1_25329375_ChIP-Seq_VCAP_Human0.89401023
81SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.88641173
82TP53_16413492_ChIP-PET_HCT116_Human0.87305016
83MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.86908303
84GATA1_19941827_ChIP-Seq_MEL_Mouse0.84679799
85PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.83397371
86VDR_22108803_ChIP-Seq_LS180_Human0.83107599
87MYC_18940864_ChIP-ChIP_HL60_Human0.82975917
88GATA3_26560356_Chip-Seq_TH1_Human0.82602501
89SOX2_22085726_ChIP-Seq_NPCs_Mouse0.82252651
90HOXB4_20404135_ChIP-ChIP_EML_Mouse0.81829608
91FOXH1_21741376_ChIP-Seq_EPCs_Human0.79634027
92NCOR_22424771_ChIP-Seq_293T_Human0.79267026
93OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.78596123
94FUS_26573619_Chip-Seq_HEK293_Human0.78233015
95CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.78001183
96GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.77909411
97TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.77908882
98LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.75311238
99AUTS2_25519132_ChIP-Seq_293T-REX_Human0.74822605
100TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.74017016

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003718_maternal_effect6.59769411
2MP0008877_abnormal_DNA_methylation4.95054419
3MP0008789_abnormal_olfactory_epithelium4.75111646
4MP0005394_taste/olfaction_phenotype4.39959803
5MP0005499_abnormal_olfactory_system4.39959803
6MP0006292_abnormal_olfactory_placode4.21782208
7MP0005464_abnormal_platelet_physiology3.65667547
8MP0005646_abnormal_pituitary_gland2.63595501
9MP0003890_abnormal_embryonic-extraembry2.59221126
10MP0008004_abnormal_stomach_pH2.42615136
11MP0000465_gastrointestinal_hemorrhage2.35836155
12MP0005395_other_phenotype2.30302463
13MP0004147_increased_porphyrin_level2.20292654
14MP0001984_abnormal_olfaction2.19782882
15MP0005410_abnormal_fertilization2.04126756
16MP0002736_abnormal_nociception_after1.99654497
17MP0002139_abnormal_hepatobiliary_system1.96529117
18MP0002735_abnormal_chemical_nociception1.90309111
19MP0002234_abnormal_pharynx_morphology1.86471172
20MP0003656_abnormal_erythrocyte_physiolo1.82344780
21MP0003699_abnormal_female_reproductive1.75724014
22MP0003879_abnormal_hair_cell1.70657708
23MP0008058_abnormal_DNA_repair1.67720131
24MP0001545_abnormal_hematopoietic_system1.66836773
25MP0005397_hematopoietic_system_phenotyp1.66836773
26MP0006276_abnormal_autonomic_nervous1.66777458
27MP0001929_abnormal_gametogenesis1.65786962
28MP0000566_synostosis1.58018674
29MP0003121_genomic_imprinting1.56052859
30MP0001968_abnormal_touch/_nociception1.54953771
31MP0002210_abnormal_sex_determination1.49291985
32MP0003183_abnormal_peptide_metabolism1.49144163
33MP0005360_urolithiasis1.46327422
34MP0004142_abnormal_muscle_tone1.40762587
35MP0002138_abnormal_hepatobiliary_system1.40105261
36MP0000653_abnormal_sex_gland1.35280194
37MP0001986_abnormal_taste_sensitivity1.34046666
38MP0002653_abnormal_ependyma_morphology1.33764786
39MP0002161_abnormal_fertility/fecundity1.31847062
40MP0003698_abnormal_male_reproductive1.17772867
41MP0000230_abnormal_systemic_arterial1.17455406
42MP0010368_abnormal_lymphatic_system1.16928900
43MP0001905_abnormal_dopamine_level1.16227207
44MP0002272_abnormal_nervous_system1.16209339
45MP0005075_abnormal_melanosome_morpholog1.15934432
46MP0001529_abnormal_vocalization1.13878048
47MP0002160_abnormal_reproductive_system1.10501013
48MP0005551_abnormal_eye_electrophysiolog1.04736629
49MP0001145_abnormal_male_reproductive0.99783188
50MP0003880_abnormal_central_pattern0.98660386
51MP0001119_abnormal_female_reproductive0.96647798
52MP0003693_abnormal_embryo_hatching0.93503841
53MP0004084_abnormal_cardiac_muscle0.92750005
54MP0010030_abnormal_orbit_morphology0.92567158
55MP0008775_abnormal_heart_ventricle0.91636599
56MP0003787_abnormal_imprinting0.91599817
57MP0004859_abnormal_synaptic_plasticity0.89105506
58MP0005645_abnormal_hypothalamus_physiol0.87803347
59MP0001664_abnormal_digestion0.84015282
60MP0002638_abnormal_pupillary_reflex0.83368189
61MP0005167_abnormal_blood-brain_barrier0.82852095
62MP0003186_abnormal_redox_activity0.81551642
63MP0000631_abnormal_neuroendocrine_gland0.80244711
64MP0002734_abnormal_mechanical_nocicepti0.79471730
65MP0005085_abnormal_gallbladder_physiolo0.79234108
66MP0003077_abnormal_cell_cycle0.78986245
67MP0003252_abnormal_bile_duct0.78507616
68MP0003122_maternal_imprinting0.76877738
69MP0002733_abnormal_thermal_nociception0.76725240
70MP0010094_abnormal_chromosome_stability0.75047500
71MP0008872_abnormal_physiological_respon0.72471224
72MP0005389_reproductive_system_phenotype0.72156552
73MP0002233_abnormal_nose_morphology0.72097949
74MP0002067_abnormal_sensory_capabilities0.71260557
75MP0008932_abnormal_embryonic_tissue0.71225441
76MP0005647_abnormal_sex_gland0.69488670
77MP0001486_abnormal_startle_reflex0.68993110
78MP0003724_increased_susceptibility_to0.68574309
79MP0003119_abnormal_digestive_system0.67341097
80MP0001970_abnormal_pain_threshold0.67005212
81MP0000372_irregular_coat_pigmentation0.65797661
82MP0008995_early_reproductive_senescence0.65083773
83MP0003635_abnormal_synaptic_transmissio0.63086509
84MP0004133_heterotaxia0.61400482
85MP0003136_yellow_coat_color0.60598426
86MP0005423_abnormal_somatic_nervous0.59887058
87MP0002572_abnormal_emotion/affect_behav0.59732986
88MP0009765_abnormal_xenobiotic_induced0.57340320
89MP0009745_abnormal_behavioral_response0.56118691
90MP0002019_abnormal_tumor_incidence0.55337705
91MP0002132_abnormal_respiratory_system0.54565611
92MP0001293_anophthalmia0.54498481
93MP0001324_abnormal_eye_pigmentation0.54089521
94MP0000015_abnormal_ear_pigmentation0.53095563
95MP0001666_abnormal_nutrient_absorption0.52456400
96MP0002398_abnormal_bone_marrow0.49936073
97MP0006036_abnormal_mitochondrial_physio0.49098040
98MP0004811_abnormal_neuron_physiology0.48304828
99MP0005174_abnormal_tail_pigmentation0.48244587
100MP0008057_abnormal_DNA_replication0.48075420

Predicted human phenotypes

RankGene SetZ-score
1Supernumerary spleens (HP:0009799)5.45744101
2Prolonged bleeding time (HP:0003010)5.37632795
3Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)5.09408215
4Increased mean platelet volume (HP:0011877)4.68257015
5Abnormal platelet volume (HP:0011876)4.34714528
6Menorrhagia (HP:0000132)4.32311901
7Agnosia (HP:0010524)4.03305072
8Petechiae (HP:0000967)3.91732890
9Anterior segment dysgenesis (HP:0007700)3.81829880
10Ependymoma (HP:0002888)3.75041797
11Purpura (HP:0000979)3.52446231
12Abnormal gallbladder physiology (HP:0012438)3.52236243
13Cholecystitis (HP:0001082)3.52236243
14Epistaxis (HP:0000421)3.46558533
15Medulloblastoma (HP:0002885)3.38328970
16Male infertility (HP:0003251)3.38061217
17Short tibia (HP:0005736)3.30688330
18Abnormality of abdominal situs (HP:0011620)3.29187937
19Abdominal situs inversus (HP:0003363)3.29187937
20Biliary tract neoplasm (HP:0100574)3.28651506
21Rhabdomyosarcoma (HP:0002859)3.27912738
22Infertility (HP:0000789)3.20367713
23Abnormal ciliary motility (HP:0012262)3.19991346
24Generalized aminoaciduria (HP:0002909)3.16359935
25Median cleft lip (HP:0000161)3.11729313
26Hypophosphatemic rickets (HP:0004912)3.08632211
27Aplasia/Hypoplasia of the fovea (HP:0008060)3.01285042
28Hypoplasia of the fovea (HP:0007750)3.01285042
29Gingival bleeding (HP:0000225)2.98750207
30Abnormality of the heme biosynthetic pathway (HP:0010472)2.97428015
31Aplasia/Hypoplasia of the tibia (HP:0005772)2.97359911
32Neoplasm of the oral cavity (HP:0100649)2.89902525
33Septo-optic dysplasia (HP:0100842)2.89293664
34Conjunctival telangiectasia (HP:0000524)2.88371201
35Abnormality of the labia minora (HP:0012880)2.86124993
36Dyschromatopsia (HP:0007641)2.85119856
37Facial hemangioma (HP:0000329)2.82949844
38Abnormality of the fovea (HP:0000493)2.81862657
39Azoospermia (HP:0000027)2.81440783
40Impulsivity (HP:0100710)2.75598104
41Aplastic anemia (HP:0001915)2.74941295
42Medial flaring of the eyebrow (HP:0010747)2.72135140
43Astrocytoma (HP:0009592)2.69979959
44Abnormality of the astrocytes (HP:0100707)2.69979959
45Amaurosis fugax (HP:0100576)2.64337750
46Papillary thyroid carcinoma (HP:0002895)2.64191640
47Decreased central vision (HP:0007663)2.62877456
48Lip pit (HP:0100267)2.57265837
49Gait imbalance (HP:0002141)2.54203975
50Abnormality of the vasculature of the conjunctiva (HP:0008054)2.48328623
51Congenital primary aphakia (HP:0007707)2.45522075
52Abnormal respiratory motile cilium physiology (HP:0012261)2.40726439
53Nausea (HP:0002018)2.39289753
54Abnormal spermatogenesis (HP:0008669)2.36219433
55Osteomalacia (HP:0002749)2.36060901
56Gonadotropin excess (HP:0000837)2.35362471
57Absent septum pellucidum (HP:0001331)2.34793939
58Nephrogenic diabetes insipidus (HP:0009806)2.34268584
59Oligodactyly (hands) (HP:0001180)2.30390372
60Abnormality of lateral ventricle (HP:0030047)2.27151905
61Thyroid carcinoma (HP:0002890)2.24936265
62Premature ovarian failure (HP:0008209)2.21761616
63Abnormal respiratory epithelium morphology (HP:0012253)2.20637088
64Abnormal respiratory motile cilium morphology (HP:0005938)2.20637088
65Glioma (HP:0009733)2.20214615
66Myokymia (HP:0002411)2.18857009
673-Methylglutaconic aciduria (HP:0003535)2.17497440
68Hyperlipoproteinemia (HP:0010980)2.13132403
69Cone-rod dystrophy (HP:0000548)2.08896494
70Abnormal platelet function (HP:0011869)2.08836320
71Impaired platelet aggregation (HP:0003540)2.08836320
72Abnormality of the septum pellucidum (HP:0007375)2.04164275
73Central scotoma (HP:0000603)2.01771548
74Neoplasm of striated muscle (HP:0009728)2.00572469
75Renal cortical cysts (HP:0000803)1.99974234
76Thyroid-stimulating hormone excess (HP:0002925)1.99538890
77Acute lymphatic leukemia (HP:0006721)1.97507875
78Dysdiadochokinesis (HP:0002075)1.95877299
79Neoplasm of the rectum (HP:0100743)1.94777547
80Neoplasm of the small intestine (HP:0100833)1.92304113
81Polyphagia (HP:0002591)1.90989185
82Spontaneous abortion (HP:0005268)1.87762766
83Aplasia/Hypoplasia of the tongue (HP:0010295)1.85811546
84Neurodegeneration (HP:0002180)1.83688334
85Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.81738448
86Bundle branch block (HP:0011710)1.78616972
87Genital tract atresia (HP:0001827)1.77206918
88Renal Fanconi syndrome (HP:0001994)1.75996011
89Abnormality of midbrain morphology (HP:0002418)1.75005410
90Molar tooth sign on MRI (HP:0002419)1.75005410
91Abnormality of the salivary glands (HP:0010286)1.74481515
92Acanthocytosis (HP:0001927)1.71864921
93Abnormal biliary tract physiology (HP:0012439)1.70835955
94Bile duct proliferation (HP:0001408)1.70835955
95Abnormal auditory evoked potentials (HP:0006958)1.69934797
96Tubulointerstitial nephritis (HP:0001970)1.69375625
97Aplasia/Hypoplasia of the macula (HP:0008059)1.69329741
98Rhinitis (HP:0012384)1.69109386
99Abnormality of the phalanges of the hallux (HP:0010057)1.68368759
100Poikilocytosis (HP:0004447)1.65442867

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K24.39158670
2ARAF4.01053468
3TAOK33.97123651
4MAP3K133.21201697
5MAP3K92.61239999
6TNIK2.19752281
7MST41.93423277
8CDK91.81154786
9CCNB11.75646958
10TRIM281.75643563
11TNK21.74857011
12MAPK131.72670900
13TEC1.70167724
14EIF2AK11.67848572
15NEK61.67606818
16CSF1R1.63188682
17PAK41.62388793
18BCKDK1.58138460
19DYRK31.55968595
20FLT31.55695317
21MATK1.55364942
22STK241.54760515
23NUAK11.51972306
24BMX1.51061284
25PNCK1.50887220
26PBK1.50144590
27AURKA1.49242000
28NTRK21.41889363
29EIF2AK31.35170497
30BMPR1B1.33911845
31MET1.30448957
32RAF11.23553625
33PKN11.22453131
34SRPK11.22372025
35TIE11.21327713
36ACVR1B1.21298645
37RIPK41.18095767
38BRAF1.12467151
39ZAK1.10407153
40BTK1.09228896
41CSNK1G31.06463800
42PTK2B1.06368761
43MAP2K31.03460595
44VRK10.98859241
45KIT0.98184894
46CSNK1G10.96086066
47PRKCI0.94877427
48TLK10.89534205
49CSNK1D0.87516283
50SYK0.84886608
51STK30.84157864
52DYRK1B0.83093282
53CDC70.78891188
54MOS0.76039088
55PIM20.75003683
56BMPR20.74340613
57PIM10.72532186
58DYRK20.71920296
59CAMK10.70228888
60PRKG10.69229522
61CAMK2A0.68031491
62TGFBR10.68021579
63MYLK0.66104232
64PIK3CG0.65349911
65TTK0.64108995
66CSNK1A1L0.63399065
67FES0.61915628
68ERBB30.61414109
69MAP3K50.61333187
70CSNK1G20.59358428
71ADRBK20.59313887
72PLK30.58786732
73PRKACA0.58687292
74CDK70.56186957
75DYRK1A0.52075384
76GRK50.50352241
77ADRBK10.49386857
78PAK10.47295379
79PRKCQ0.44210303
80ITK0.41364618
81IKBKB0.41107987
82PDK20.40700165
83PLK10.40384260
84MAP2K70.39808000
85ILK0.39753604
86CDK80.39119617
87PRKACB0.36904435
88MAP3K40.35681958
89CDK20.35615107
90RET0.34883659
91MARK10.34377029
92MARK30.34312404
93PRKCA0.33620613
94TXK0.31569736
95PRKACG0.31535280
96MELK0.31252868
97HCK0.30298960
98ATM0.29612624
99KDR0.29592014
100LYN0.29066534

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034303.89383410
2Basal transcription factors_Homo sapiens_hsa030223.66844638
3SNARE interactions in vesicular transport_Homo sapiens_hsa041302.92767755
4Olfactory transduction_Homo sapiens_hsa047402.86504566
5Platelet activation_Homo sapiens_hsa046112.65065077
6Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.63266412
7Ovarian steroidogenesis_Homo sapiens_hsa049132.58287051
8Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.36830154
9Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.28880338
10Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.23283206
11Nicotine addiction_Homo sapiens_hsa050332.15094363
12Phototransduction_Homo sapiens_hsa047442.07916211
13Oocyte meiosis_Homo sapiens_hsa041142.00205439
14Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.96506021
15GABAergic synapse_Homo sapiens_hsa047271.91354065
16Cell cycle_Homo sapiens_hsa041101.91067377
17Morphine addiction_Homo sapiens_hsa050321.82600170
18Gap junction_Homo sapiens_hsa045401.81156261
19Fatty acid elongation_Homo sapiens_hsa000621.75150494
20Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.66026064
21alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.64404966
22Base excision repair_Homo sapiens_hsa034101.64227953
23Homologous recombination_Homo sapiens_hsa034401.62416008
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.61115394
25Caffeine metabolism_Homo sapiens_hsa002321.58783785
26Taste transduction_Homo sapiens_hsa047421.57571427
27RNA degradation_Homo sapiens_hsa030181.53742609
28Serotonergic synapse_Homo sapiens_hsa047261.52698140
29Arachidonic acid metabolism_Homo sapiens_hsa005901.49011095
30Fanconi anemia pathway_Homo sapiens_hsa034601.47881247
31Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.40650711
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.40363551
33Nucleotide excision repair_Homo sapiens_hsa034201.27272215
34Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.26283089
35Linoleic acid metabolism_Homo sapiens_hsa005911.21675892
36Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.21568675
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.18094349
38Circadian rhythm_Homo sapiens_hsa047101.17282807
39Circadian entrainment_Homo sapiens_hsa047131.13660753
40RNA polymerase_Homo sapiens_hsa030201.06208287
41Parkinsons disease_Homo sapiens_hsa050121.03497336
42Hematopoietic cell lineage_Homo sapiens_hsa046400.97211353
43Regulation of autophagy_Homo sapiens_hsa041400.96624635
44Synaptic vesicle cycle_Homo sapiens_hsa047210.94986574
45Purine metabolism_Homo sapiens_hsa002300.93788738
46Peroxisome_Homo sapiens_hsa041460.93190126
47Propanoate metabolism_Homo sapiens_hsa006400.92661981
48Long-term depression_Homo sapiens_hsa047300.90301443
49Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.81591870
50Collecting duct acid secretion_Homo sapiens_hsa049660.78851659
51Alcoholism_Homo sapiens_hsa050340.78820300
52Nitrogen metabolism_Homo sapiens_hsa009100.77857592
53ABC transporters_Homo sapiens_hsa020100.77513594
54Inositol phosphate metabolism_Homo sapiens_hsa005620.76849571
55Calcium signaling pathway_Homo sapiens_hsa040200.75140888
56Glutamatergic synapse_Homo sapiens_hsa047240.73344437
57RNA transport_Homo sapiens_hsa030130.70170946
58Pyrimidine metabolism_Homo sapiens_hsa002400.68264446
59p53 signaling pathway_Homo sapiens_hsa041150.68220003
60Huntingtons disease_Homo sapiens_hsa050160.66374398
61Primary bile acid biosynthesis_Homo sapiens_hsa001200.64625030
62Phosphatidylinositol signaling system_Homo sapiens_hsa040700.64332052
63Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.59261387
64Glycerophospholipid metabolism_Homo sapiens_hsa005640.53815028
65Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.51642180
66Ras signaling pathway_Homo sapiens_hsa040140.51229224
67Cholinergic synapse_Homo sapiens_hsa047250.50625986
68Transcriptional misregulation in cancer_Homo sapiens_hsa052020.49840377
69Vascular smooth muscle contraction_Homo sapiens_hsa042700.49683525
70Asthma_Homo sapiens_hsa053100.48663758
71Chemokine signaling pathway_Homo sapiens_hsa040620.47323696
72Ether lipid metabolism_Homo sapiens_hsa005650.45404058
73ECM-receptor interaction_Homo sapiens_hsa045120.45012426
74Dopaminergic synapse_Homo sapiens_hsa047280.44124678
75Chemical carcinogenesis_Homo sapiens_hsa052040.43874183
76Pancreatic secretion_Homo sapiens_hsa049720.43507648
77TGF-beta signaling pathway_Homo sapiens_hsa043500.43247211
78Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.43022577
79Glycosaminoglycan degradation_Homo sapiens_hsa005310.42379570
80Vitamin digestion and absorption_Homo sapiens_hsa049770.40857327
81Systemic lupus erythematosus_Homo sapiens_hsa053220.40853603
82Oxidative phosphorylation_Homo sapiens_hsa001900.40270117
83Ribosome_Homo sapiens_hsa030100.39949049
84Aldosterone synthesis and secretion_Homo sapiens_hsa049250.39929686
85Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.37889154
86Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.36157702
87Oxytocin signaling pathway_Homo sapiens_hsa049210.35642558
88Dorso-ventral axis formation_Homo sapiens_hsa043200.35314174
89Glycerolipid metabolism_Homo sapiens_hsa005610.35042172
90Phagosome_Homo sapiens_hsa041450.34318212
91Glutathione metabolism_Homo sapiens_hsa004800.33099065
92Cardiac muscle contraction_Homo sapiens_hsa042600.31130582
93Renin-angiotensin system_Homo sapiens_hsa046140.29760561
94Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.28842616
95Cocaine addiction_Homo sapiens_hsa050300.28763697
96Metabolic pathways_Homo sapiens_hsa011000.28476423
97Salivary secretion_Homo sapiens_hsa049700.25882471
98Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.25447890
99Colorectal cancer_Homo sapiens_hsa052100.25099117
100Bile secretion_Homo sapiens_hsa049760.25062832

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