CLK4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the CDC2-like protein kinase (CLK) family. This protein kinase can interact with and phosphorylate the serine- and arginine-rich (SR) proteins, which are known to play an important role in the formation of spliceosomes, and thus may be involved in the regulation of alternative splicing. Studies in the Israeli sand rat Psammomys obesus suggested that the ubiquitin-like 5 (UBL5/BEACON), a highly conserved ubiquitin-like protein, may interact with and regulate the activity of this kinase. Multiple alternatively spliced transcript variants have been observed, but the full-length natures of which have not yet been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)5.66852358
2central nervous system myelination (GO:0022010)5.66852358
3poly(A)+ mRNA export from nucleus (GO:0016973)5.23232441
4presynaptic membrane assembly (GO:0097105)4.95370341
5negative regulation of neurotransmitter secretion (GO:0046929)4.88398956
6presynaptic membrane organization (GO:0097090)4.36272635
7negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.09498342
8negative regulation of cell killing (GO:0031342)4.09498342
9histone H3-K4 trimethylation (GO:0080182)4.07295924
10negative regulation of neurotransmitter transport (GO:0051589)3.97705493
11establishment of protein localization to Golgi (GO:0072600)3.78992229
12fatty acid elongation (GO:0030497)3.73936512
13cellular response to interleukin-15 (GO:0071350)3.72490223
14regulation of B cell receptor signaling pathway (GO:0050855)3.68419816
15fucose catabolic process (GO:0019317)3.67679821
16L-fucose metabolic process (GO:0042354)3.67679821
17L-fucose catabolic process (GO:0042355)3.67679821
18preassembly of GPI anchor in ER membrane (GO:0016254)3.57757161
19protein targeting to Golgi (GO:0000042)3.57032696
20negative regulation of protein localization to cell surface (GO:2000009)3.52063039
21response to interleukin-15 (GO:0070672)3.49592446
22replication fork processing (GO:0031297)3.37064231
23oligodendrocyte differentiation (GO:0048709)3.36112246
24retrograde transport, vesicle recycling within Golgi (GO:0000301)3.33893548
25positive regulation of developmental pigmentation (GO:0048087)3.30989956
26negative T cell selection (GO:0043383)3.26802928
27protein K11-linked deubiquitination (GO:0035871)3.24733212
28DNA integration (GO:0015074)3.24583921
29GPI anchor biosynthetic process (GO:0006506)3.24090166
30regulation of gamma-delta T cell differentiation (GO:0045586)3.23359860
31regulation of gamma-delta T cell activation (GO:0046643)3.20731065
32response to pheromone (GO:0019236)3.20572327
33neural tube formation (GO:0001841)3.20427256
34lymphoid progenitor cell differentiation (GO:0002320)3.19021044
35myelination (GO:0042552)3.17527674
36interferon-gamma production (GO:0032609)3.14480191
37mannosylation (GO:0097502)3.13497982
38ensheathment of neurons (GO:0007272)3.13481868
39axon ensheathment (GO:0008366)3.13481868
40GPI anchor metabolic process (GO:0006505)3.11455232
41regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.07969305
42membrane tubulation (GO:0097320)3.07471117
43developmental pigmentation (GO:0048066)3.05986993
44postsynaptic membrane organization (GO:0001941)3.03835309
45negative regulation of mast cell activation (GO:0033004)3.03234493
46C-terminal protein lipidation (GO:0006501)3.01939641
47negative thymic T cell selection (GO:0045060)3.01710837
48neuron cell-cell adhesion (GO:0007158)3.00976086
49negative regulation of T cell mediated immunity (GO:0002710)2.98822160
50regulation of memory T cell differentiation (GO:0043380)2.97507444
51long-chain fatty acid biosynthetic process (GO:0042759)2.96754634
52mast cell activation (GO:0045576)2.96408477
53positive T cell selection (GO:0043368)2.96303578
54cyclic nucleotide catabolic process (GO:0009214)2.94491943
55regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.94446620
56cellular response to ethanol (GO:0071361)2.93928909
57negative regulation of lymphocyte mediated immunity (GO:0002707)2.91593631
58regulation of respiratory system process (GO:0044065)2.86483560
59oxidative demethylation (GO:0070989)2.83271877
60DNA strand renaturation (GO:0000733)2.82482348
61leukocyte migration involved in inflammatory response (GO:0002523)2.82108434
62cilium or flagellum-dependent cell motility (GO:0001539)2.81952338
63negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.80195640
64negative regulation of T-helper cell differentiation (GO:0045623)2.80195640
65nucleotide transmembrane transport (GO:1901679)2.79208256
66positive regulation of cellular amine metabolic process (GO:0033240)2.78171271
67regulation of pigment cell differentiation (GO:0050932)2.77241123
68positive regulation of granulocyte differentiation (GO:0030854)2.76913964
69cellular response to ATP (GO:0071318)2.76829665
70antigen processing and presentation of endogenous antigen (GO:0019883)2.76805652
71response to redox state (GO:0051775)2.76429670
72negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.75921295
73proline biosynthetic process (GO:0006561)2.75584084
74regulation of germinal center formation (GO:0002634)2.72119065
75regulation of MHC class I biosynthetic process (GO:0045343)2.69795060
76phagocytosis, engulfment (GO:0006911)2.69412288
77proline metabolic process (GO:0006560)2.68777831
78mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.68276679
79positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.68276679
80antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.68269348
81protein localization to Golgi apparatus (GO:0034067)2.67667116
82signal peptide processing (GO:0006465)2.65084370
83negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.64641971
84tyrosine phosphorylation of STAT protein (GO:0007260)2.64345013
85mast cell activation involved in immune response (GO:0002279)2.63342319
86mast cell degranulation (GO:0043303)2.63342319
87DNA deamination (GO:0045006)2.63061619
88membrane invagination (GO:0010324)2.62269659
89microglial cell activation (GO:0001774)2.61410350
90phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.61328260
91negative regulation of immunoglobulin mediated immune response (GO:0002890)2.61127109
92negative regulation of B cell mediated immunity (GO:0002713)2.61127109
93regulation of T cell mediated cytotoxicity (GO:0001914)2.60120474
94positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.59763450
95neutrophil mediated immunity (GO:0002446)2.59313020
96L-amino acid import (GO:0043092)2.57953321
97regulation of developmental pigmentation (GO:0048070)2.57933302
98myeloid leukocyte mediated immunity (GO:0002444)2.57106728
99negative regulation of adaptive immune response (GO:0002820)2.55790055
100eye photoreceptor cell differentiation (GO:0001754)2.55735833
101photoreceptor cell differentiation (GO:0046530)2.55735833
102retina layer formation (GO:0010842)2.55029410
103C-terminal protein amino acid modification (GO:0018410)2.54993023
104regulation of regulatory T cell differentiation (GO:0045589)2.54258564
105definitive hemopoiesis (GO:0060216)2.53477996
106protein K63-linked deubiquitination (GO:0070536)2.52641539
107positive regulation of protein homooligomerization (GO:0032464)2.52501194
108monoubiquitinated protein deubiquitination (GO:0035520)2.51870461
109leukocyte aggregation (GO:0070486)2.51809045
110positive regulation of cellular amide metabolic process (GO:0034250)2.51250301
111detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.50918687
112regulation of interleukin-12 biosynthetic process (GO:0045075)2.49944859
113polyketide metabolic process (GO:0030638)2.49287680
114doxorubicin metabolic process (GO:0044598)2.49287680
115daunorubicin metabolic process (GO:0044597)2.49287680
116glycerophospholipid catabolic process (GO:0046475)2.49141421
117interleukin-6-mediated signaling pathway (GO:0070102)2.48597511
118G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.47697219
119histone H3 deacetylation (GO:0070932)2.46523978
120positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.46421988
121lateral sprouting from an epithelium (GO:0060601)2.44864270
122cAMP catabolic process (GO:0006198)2.43959531
123neutrophil activation (GO:0042119)2.42624962
124antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.42223311
125positive thymic T cell selection (GO:0045059)2.41615614
126regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.39045074
127glycolipid biosynthetic process (GO:0009247)2.39037085
128epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.38697839
129antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.38016978
130auditory receptor cell stereocilium organization (GO:0060088)2.37144762
131protein localization to cilium (GO:0061512)2.36189439
132regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.36178139
133positive regulation of gamma-delta T cell activation (GO:0046645)2.35874480
134Golgi to endosome transport (GO:0006895)2.35666464
135cellular extravasation (GO:0045123)2.35151720
136detection of light stimulus involved in visual perception (GO:0050908)2.34080337
137detection of light stimulus involved in sensory perception (GO:0050962)2.34080337
138B cell receptor signaling pathway (GO:0050853)2.33823133
139regulation of mast cell activation (GO:0033003)2.33817825
140positive regulation of defense response to virus by host (GO:0002230)2.33673182
141piRNA metabolic process (GO:0034587)2.32300624
142regulation of alpha-beta T cell proliferation (GO:0046640)2.32182251
143ER overload response (GO:0006983)2.32175521
144DNA ligation (GO:0006266)2.31348263
145behavioral response to nicotine (GO:0035095)2.31294633
146peptidyl-lysine trimethylation (GO:0018023)2.31065453
147rRNA catabolic process (GO:0016075)2.30643679
148activated T cell proliferation (GO:0050798)2.29692126
149regulation of beta-amyloid formation (GO:1902003)2.29503815
150regulation of cell proliferation involved in kidney development (GO:1901722)2.29494381
151mRNA splice site selection (GO:0006376)2.28514380
152regulation of collateral sprouting (GO:0048670)2.27997039
153regulation of cilium movement (GO:0003352)2.27777455
154negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.27045270
155negative regulation of translation, ncRNA-mediated (GO:0040033)2.27045270
156regulation of translation, ncRNA-mediated (GO:0045974)2.27045270
157negative regulation of myoblast differentiation (GO:0045662)2.26987956
158peptidyl-tyrosine autophosphorylation (GO:0038083)2.26020891
159antigen receptor-mediated signaling pathway (GO:0050851)2.25000889
160cellular response to epinephrine stimulus (GO:0071872)2.24769531
161positive regulation of interleukin-1 beta secretion (GO:0050718)2.24719531
162axoneme assembly (GO:0035082)2.24323948
163regulation of respiratory gaseous exchange (GO:0043576)2.23105217
164epithelial cilium movement (GO:0003351)2.22877968
165platelet dense granule organization (GO:0060155)2.22508759
166regulation of leukocyte mediated cytotoxicity (GO:0001910)2.22126732
167viral mRNA export from host cell nucleus (GO:0046784)2.21646564
168V(D)J recombination (GO:0033151)2.21638477
169response to epinephrine (GO:0071871)2.21185137
170asymmetric protein localization (GO:0008105)2.21121249
171inner ear receptor stereocilium organization (GO:0060122)2.20453762
172leukocyte degranulation (GO:0043299)2.19676383
173sphingomyelin metabolic process (GO:0006684)2.19485203
174protein K48-linked deubiquitination (GO:0071108)2.19333029
175indolalkylamine metabolic process (GO:0006586)2.18795218
176embryonic process involved in female pregnancy (GO:0060136)2.18763319
177positive regulation of T cell mediated cytotoxicity (GO:0001916)2.18650608
178positive regulation of antigen processing and presentation (GO:0002579)2.18021999
179T cell migration (GO:0072678)2.17692092
180detection of molecule of bacterial origin (GO:0032490)2.17622894
181pyrimidine ribonucleoside catabolic process (GO:0046133)2.17405291
182transmission of nerve impulse (GO:0019226)2.17269149
183regulation of cell killing (GO:0031341)2.16331744
184interferon-gamma-mediated signaling pathway (GO:0060333)2.16163965
185cytidine catabolic process (GO:0006216)2.16153469

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.22254142
2GBX2_23144817_ChIP-Seq_PC3_Human3.30222955
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.05476022
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.50392637
5TAF15_26573619_Chip-Seq_HEK293_Human2.49020051
6* ZNF274_21170338_ChIP-Seq_K562_Hela2.34234423
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.23497838
8BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.16165186
9VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.10515468
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.10423751
11EZH2_22144423_ChIP-Seq_EOC_Human2.05842942
12IGF1R_20145208_ChIP-Seq_DFB_Human2.02808080
13CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.96406417
14PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.93342301
15TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.92553012
16IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.85931964
17STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.85588616
18AR_21572438_ChIP-Seq_LNCaP_Human1.84820962
19IRF8_22096565_ChIP-ChIP_GC-B_Human1.84334277
20NANOG_18555785_Chip-Seq_ESCs_Mouse1.75922281
21AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.72726194
22PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.71371175
23SUZ12_18555785_Chip-Seq_ESCs_Mouse1.70972476
24LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.68647144
25CTBP2_25329375_ChIP-Seq_LNCAP_Human1.67763776
26IRF1_19129219_ChIP-ChIP_H3396_Human1.66227481
27FUS_26573619_Chip-Seq_HEK293_Human1.64821282
28P300_18555785_Chip-Seq_ESCs_Mouse1.64695755
29TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.64631361
30RUNX_20019798_ChIP-Seq_JUKART_Human1.62368638
31SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.61562257
32STAT3_18555785_Chip-Seq_ESCs_Mouse1.61505695
33P300_19829295_ChIP-Seq_ESCs_Human1.59559251
34CMYC_18555785_Chip-Seq_ESCs_Mouse1.58441545
35IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.57253314
36E2F1_18555785_Chip-Seq_ESCs_Mouse1.55337954
37UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.54840591
38P53_22387025_ChIP-Seq_ESCs_Mouse1.54621500
39SMAD_19615063_ChIP-ChIP_OVARY_Human1.54341923
40SUZ12_27294783_Chip-Seq_NPCs_Mouse1.52789325
41SALL1_21062744_ChIP-ChIP_HESCs_Human1.52674007
42VDR_22108803_ChIP-Seq_LS180_Human1.52390730
43SCL_19346495_ChIP-Seq_HPC-7_Human1.51020422
44SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.50995230
45EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.49852609
46RUNX1_27457419_Chip-Seq_LIVER_Mouse1.49830955
47OCT4_18555785_Chip-Seq_ESCs_Mouse1.48742147
48PCGF2_27294783_Chip-Seq_NPCs_Mouse1.48050319
49PCGF2_27294783_Chip-Seq_ESCs_Mouse1.46688752
50EWS_26573619_Chip-Seq_HEK293_Human1.45171872
51NOTCH1_21737748_ChIP-Seq_TLL_Human1.43026747
52GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42238439
53BCAT_22108803_ChIP-Seq_LS180_Human1.41105564
54SOX2_18555785_Chip-Seq_ESCs_Mouse1.39915099
55PRDM14_20953172_ChIP-Seq_ESCs_Human1.39866907
56FLI1_27457419_Chip-Seq_LIVER_Mouse1.39680149
57IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.39679383
58CBP_20019798_ChIP-Seq_JUKART_Human1.39679383
59NFE2_27457419_Chip-Seq_LIVER_Mouse1.38981878
60CTBP1_25329375_ChIP-Seq_LNCAP_Human1.37827557
61EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.37313906
62EZH2_27294783_Chip-Seq_NPCs_Mouse1.37303200
63CBX2_27304074_Chip-Seq_ESCs_Mouse1.36841396
64GATA3_26560356_Chip-Seq_TH2_Human1.36319381
65RNF2_27304074_Chip-Seq_NSC_Mouse1.33785208
66OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33106667
67TAL1_26923725_Chip-Seq_HPCs_Mouse1.31597693
68SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.31472334
69KLF4_18555785_Chip-Seq_ESCs_Mouse1.31297233
70FLI1_21867929_ChIP-Seq_TH2_Mouse1.30887699
71NR3C1_21868756_ChIP-Seq_MCF10A_Human1.30738630
72CTCF_18555785_Chip-Seq_ESCs_Mouse1.30697641
73NMYC_18555785_Chip-Seq_ESCs_Mouse1.30608905
74MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.30326580
75STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.29429552
76LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.29211229
77RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.27826598
78ER_23166858_ChIP-Seq_MCF-7_Human1.27556682
79BMI1_23680149_ChIP-Seq_NPCS_Mouse1.27409948
80P53_22127205_ChIP-Seq_FIBROBLAST_Human1.27154402
81PU1_27457419_Chip-Seq_LIVER_Mouse1.26861173
82BP1_19119308_ChIP-ChIP_Hs578T_Human1.24411007
83SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.23207654
84SMAD3_21741376_ChIP-Seq_EPCs_Human1.21428029
85GATA3_27048872_Chip-Seq_THYMUS_Human1.20846782
86MYB_26560356_Chip-Seq_TH2_Human1.20654184
87ESRRB_18555785_Chip-Seq_ESCs_Mouse1.20467759
88RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19993772
89SMAD1_18555785_Chip-Seq_ESCs_Mouse1.19675633
90SMAD4_21799915_ChIP-Seq_A2780_Human1.19020401
91ZFX_18555785_Chip-Seq_ESCs_Mouse1.18853854
92* RUNX2_22187159_ChIP-Seq_PCA_Human1.17707049
93SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17447635
94EZH2_27304074_Chip-Seq_ESCs_Mouse1.16920355
95DROSHA_22980978_ChIP-Seq_HELA_Human1.15296845
96GATA1_22025678_ChIP-Seq_K562_Human1.15127399
97POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.14838891
98TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14838891
99CDX2_19796622_ChIP-Seq_MESCs_Mouse1.13248586
100TCF4_22108803_ChIP-Seq_LS180_Human1.12887035
101MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.12823906
102VDR_24787735_ChIP-Seq_THP-1_Human1.12820930
103PIAS1_25552417_ChIP-Seq_VCAP_Human1.12514347
104* TCF4_23295773_ChIP-Seq_U87_Human1.10853796
105CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.09423148
106EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.09364758
107FOXA1_21572438_ChIP-Seq_LNCaP_Human1.09324998
108EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.08997143
109NANOG_19829295_ChIP-Seq_ESCs_Human1.08077043
110SOX2_19829295_ChIP-Seq_ESCs_Human1.08077043
111SMRT_27268052_Chip-Seq_Bcells_Human1.07906645
112CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.07818946
113* IRF8_27001747_Chip-Seq_BMDM_Mouse1.07730826
114STAT3_23295773_ChIP-Seq_U87_Human1.07160177
115JARID2_20064375_ChIP-Seq_MESCs_Mouse1.06657392
116MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.05732323
117TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.04780516
118IRF8_21731497_ChIP-ChIP_J774_Mouse1.04177181
119SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.03178728
120ARNT_22903824_ChIP-Seq_MCF-7_Human1.03038182
121SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.03037041
122CRX_20693478_ChIP-Seq_RETINA_Mouse1.02126012
123CDX2_22108803_ChIP-Seq_LS180_Human1.01370290
124TBL1_22424771_ChIP-Seq_293T_Human1.01193427
125SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.01069094
126TP53_22573176_ChIP-Seq_HFKS_Human1.00682602
127KDM2B_26808549_Chip-Seq_REH_Human1.00014870
128SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.99841709
129TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.99564919
130MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.99339734
131* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.99066204
132SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.98895192
133PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96951738
134OCT4_21477851_ChIP-Seq_ESCs_Mouse0.96642429
135AR_25329375_ChIP-Seq_VCAP_Human0.95722115
136SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.95074169
137FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.94871055
138TOP2B_26459242_ChIP-Seq_MCF-7_Human0.93864193
139RNF2_27304074_Chip-Seq_ESCs_Mouse0.93468335
140TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93248123
141FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.93167930

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005171_absent_coat_pigmentation4.80070099
2MP0002009_preneoplasia3.65864390
3MP0000569_abnormal_digit_pigmentation3.30957646
4MP0008877_abnormal_DNA_methylation2.95513047
5MP0008057_abnormal_DNA_replication2.92333223
6MP0005409_darkened_coat_color2.79231121
7MP0000920_abnormal_myelination2.75580894
8MP0005075_abnormal_melanosome_morpholog2.67263994
9MP0003880_abnormal_central_pattern2.61453184
10MP0000015_abnormal_ear_pigmentation2.50571764
11MP0005174_abnormal_tail_pigmentation2.38348659
12MP0004147_increased_porphyrin_level2.33042537
13MP0001188_hyperpigmentation2.25571764
14MP0005646_abnormal_pituitary_gland2.24072625
15MP0002102_abnormal_ear_morphology2.16649120
16MP0003136_yellow_coat_color1.96086236
17MP0003183_abnormal_peptide_metabolism1.94630965
18MP0004381_abnormal_hair_follicle1.92980971
19MP0003646_muscle_fatigue1.89863728
20MP0001486_abnormal_startle_reflex1.88904222
21MP0003690_abnormal_glial_cell1.77766131
22MP0002166_altered_tumor_susceptibility1.74556848
23MP0005671_abnormal_response_to1.70662721
24MP0006072_abnormal_retinal_apoptosis1.66468669
25MP0003195_calcinosis1.66020848
26MP0004134_abnormal_chest_morphology1.63998418
27MP0005551_abnormal_eye_electrophysiolog1.63737598
28MP0000685_abnormal_immune_system1.63432904
29MP0005645_abnormal_hypothalamus_physiol1.62580246
30MP0003763_abnormal_thymus_physiology1.61557478
31MP0002272_abnormal_nervous_system1.61484889
32MP0001502_abnormal_circadian_rhythm1.59253454
33MP0001986_abnormal_taste_sensitivity1.55197469
34MP0002638_abnormal_pupillary_reflex1.53499247
35MP0000566_synostosis1.52594671
36MP0002064_seizures1.51296165
37MP0004142_abnormal_muscle_tone1.50852121
38MP0002138_abnormal_hepatobiliary_system1.48866584
39MP0004742_abnormal_vestibular_system1.47353832
40MP0001968_abnormal_touch/_nociception1.46676970
41MP0008569_lethality_at_weaning1.44455632
42MP0001529_abnormal_vocalization1.43868324
43MP0009745_abnormal_behavioral_response1.39246980
44MP0003011_delayed_dark_adaptation1.38918576
45MP0009697_abnormal_copulation1.38303035
46MP0000778_abnormal_nervous_system1.35077464
47MP0005253_abnormal_eye_physiology1.34501197
48MP0002095_abnormal_skin_pigmentation1.34092873
49MP0009046_muscle_twitch1.31843188
50MP0002006_tumorigenesis1.31009945
51MP0000427_abnormal_hair_cycle1.30518881
52MP0009764_decreased_sensitivity_to1.28833536
53MP0002735_abnormal_chemical_nociception1.28572416
54MP0004130_abnormal_muscle_cell1.27062900
55MP0004885_abnormal_endolymph1.25729768
56MP0008872_abnormal_physiological_respon1.24727493
57MP0003436_decreased_susceptibility_to1.24480247
58MP0001905_abnormal_dopamine_level1.23889472
59MP0006292_abnormal_olfactory_placode1.23776209
60MP0001835_abnormal_antigen_presentation1.23226195
61MP0002572_abnormal_emotion/affect_behav1.22040293
62MP0003787_abnormal_imprinting1.21106131
63MP0004043_abnormal_pH_regulation1.19386108
64MP0008995_early_reproductive_senescence1.18984594
65MP0002938_white_spotting1.18373861
66MP0002933_joint_inflammation1.16815844
67MP0006082_CNS_inflammation1.16756468
68MP0001984_abnormal_olfaction1.16340816
69MP0003950_abnormal_plasma_membrane1.15442318
70MP0002067_abnormal_sensory_capabilities1.15067139
71MP0000681_abnormal_thyroid_gland1.14314187
72MP0000372_irregular_coat_pigmentation1.13432172
73MP0001800_abnormal_humoral_immune1.11059389
74MP0005386_behavior/neurological_phenoty1.08466529
75MP0004924_abnormal_behavior1.08466529
76MP0003724_increased_susceptibility_to1.07355482
77MP0003866_abnormal_defecation1.07313066
78MP0000465_gastrointestinal_hemorrhage1.07111228
79MP0005387_immune_system_phenotype1.06707678
80MP0001790_abnormal_immune_system1.06707678
81MP0002419_abnormal_innate_immunity1.06023224
82MP0005423_abnormal_somatic_nervous1.05988337
83MP0002277_abnormal_respiratory_mucosa1.05312186
84MP0002723_abnormal_immune_serum1.04813612
85MP0005310_abnormal_salivary_gland1.04500391
86MP0004484_altered_response_of1.04024885
87MP0002420_abnormal_adaptive_immunity1.03949281
88MP0001501_abnormal_sleep_pattern1.03733865
89MP0001873_stomach_inflammation1.03331992
90MP0009785_altered_susceptibility_to1.01182670
91MP0002876_abnormal_thyroid_physiology1.00039564
92MP0001963_abnormal_hearing_physiology0.99659041
93MP0001819_abnormal_immune_cell0.99653097
94MP0001485_abnormal_pinna_reflex0.98682262
95MP0002736_abnormal_nociception_after0.98172359
96MP0002928_abnormal_bile_duct0.97477974
97MP0004270_analgesia0.97131203
98MP0005167_abnormal_blood-brain_barrier0.96806521
99MP0006276_abnormal_autonomic_nervous0.95741621
100MP0003633_abnormal_nervous_system0.95131210
101MP0002332_abnormal_exercise_endurance0.93791638
102MP0002229_neurodegeneration0.93575890
103MP0003634_abnormal_glial_cell0.93430607
104MP0001970_abnormal_pain_threshold0.93421955
105MP0000631_abnormal_neuroendocrine_gland0.93048509
106MP0005025_abnormal_response_to0.92799265
107MP0002722_abnormal_immune_system0.92759069
108MP0002452_abnormal_antigen_presenting0.92517752
109MP0000703_abnormal_thymus_morphology0.91368537
110MP0003635_abnormal_synaptic_transmissio0.91006355
111MP0002398_abnormal_bone_marrow0.90575997
112MP0001845_abnormal_inflammatory_respons0.90398791
113MP0004215_abnormal_myocardial_fiber0.90073272
114MP0003943_abnormal_hepatobiliary_system0.89876582
115MP0003303_peritoneal_inflammation0.89530375
116MP0002148_abnormal_hypersensitivity_rea0.89113234
117MP0005535_abnormal_body_temperature0.88278855
118MP0000470_abnormal_stomach_morphology0.87748801
119MP0008961_abnormal_basal_metabolism0.86558348
120MP0000716_abnormal_immune_system0.86218416
121MP0001851_eye_inflammation0.86094580
122MP0005000_abnormal_immune_tolerance0.85226441
123MP0002063_abnormal_learning/memory/cond0.84950210
124MP0003172_abnormal_lysosome_physiology0.84783438
125MP0000462_abnormal_digestive_system0.84550649
126MP0000689_abnormal_spleen_morphology0.82993747
127MP0001324_abnormal_eye_pigmentation0.82839899
128MP0001440_abnormal_grooming_behavior0.82124777
129MP0003631_nervous_system_phenotype0.81208752
130MP0004883_abnormal_blood_vessel0.80916088
131MP0002733_abnormal_thermal_nociception0.80800973
132MP0010386_abnormal_urinary_bladder0.80786837
133MP0002405_respiratory_system_inflammati0.80501823
134MP0004145_abnormal_muscle_electrophysio0.79705599
135MP0003656_abnormal_erythrocyte_physiolo0.79692022
136MP0003828_pulmonary_edema0.78835406
137MP0005058_abnormal_lysosome_morphology0.76152862
138MP0001186_pigmentation_phenotype0.73055145
139MP0005410_abnormal_fertilization0.72662939
140MP0003221_abnormal_cardiomyocyte_apopto0.72422189
141MP0000955_abnormal_spinal_cord0.71830903
142MP0005195_abnormal_posterior_eye0.70822997
143MP0004133_heterotaxia0.69469212

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)4.17783902
2Abnormality of T cell number (HP:0011839)4.01075952
3White forelock (HP:0002211)3.70949408
4Optic neuritis (HP:0100653)3.59236263
5Patchy hypopigmentation of hair (HP:0011365)3.56714928
6Alacrima (HP:0000522)3.47318876
7Decreased lacrimation (HP:0000633)3.27252682
8Hypothermia (HP:0002045)3.19138816
9Molar tooth sign on MRI (HP:0002419)3.13413262
10Abnormality of midbrain morphology (HP:0002418)3.13413262
11Genetic anticipation (HP:0003743)3.13153096
12Myositis (HP:0100614)3.05194786
13Pancreatic cysts (HP:0001737)3.04721568
14Anteriorly placed anus (HP:0001545)2.98716660
15Orchitis (HP:0100796)2.91851928
16Thyroid-stimulating hormone excess (HP:0002925)2.86892348
17Depressed nasal tip (HP:0000437)2.85877368
18Clumsiness (HP:0002312)2.82892736
19Thyroiditis (HP:0100646)2.80622614
20Progressive cerebellar ataxia (HP:0002073)2.79883337
21Elevated erythrocyte sedimentation rate (HP:0003565)2.78661781
22Intestinal atresia (HP:0011100)2.74505719
23Absent speech (HP:0001344)2.73193225
24Abnormality of the columella (HP:0009929)2.73144861
25Abnormality of eosinophils (HP:0001879)2.71467938
26Dynein arm defect of respiratory motile cilia (HP:0012255)2.70013802
27Absent/shortened dynein arms (HP:0200106)2.70013802
28Nephronophthisis (HP:0000090)2.69160334
29Keratoconjunctivitis (HP:0001096)2.69020723
30Pancreatic fibrosis (HP:0100732)2.67460338
313-Methylglutaconic aciduria (HP:0003535)2.64751793
32Gaze-evoked nystagmus (HP:0000640)2.64219905
33Retinal dysplasia (HP:0007973)2.61434682
34Abnormality of T cells (HP:0002843)2.61157943
35Abnormal hair whorl (HP:0010721)2.60628308
36Chronic mucocutaneous candidiasis (HP:0002728)2.60543692
37Recurrent cutaneous fungal infections (HP:0011370)2.60543692
38Epileptic encephalopathy (HP:0200134)2.59513260
39Abnormal delayed hypersensitivity skin test (HP:0002963)2.59366326
40Fair hair (HP:0002286)2.59170685
41Premature skin wrinkling (HP:0100678)2.57500456
42Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.57263466
43Degeneration of the lateral corticospinal tracts (HP:0002314)2.57263466
44Keratoconjunctivitis sicca (HP:0001097)2.57178327
45Abnormality of secondary sexual hair (HP:0009888)2.56110571
46Abnormality of the axillary hair (HP:0100134)2.56110571
47Abnormality of the renal medulla (HP:0100957)2.54168614
48Attenuation of retinal blood vessels (HP:0007843)2.49526437
49Eosinophilia (HP:0001880)2.46772567
50Absent rod-and cone-mediated responses on ERG (HP:0007688)2.46352890
51Recurrent bronchitis (HP:0002837)2.44202763
52Papilledema (HP:0001085)2.40731986
53Protruding tongue (HP:0010808)2.38163168
54Abnormality of the renal cortex (HP:0011035)2.38006044
55Increased IgM level (HP:0003496)2.35830752
56Hypoplasia of the thymus (HP:0000778)2.31535074
57Blue irides (HP:0000635)2.30029770
58Progressive inability to walk (HP:0002505)2.27766925
59Leukocytosis (HP:0001974)2.27287860
60Encephalitis (HP:0002383)2.26029648
61Medial flaring of the eyebrow (HP:0010747)2.22584726
62Febrile seizures (HP:0002373)2.21814683
63Inability to walk (HP:0002540)2.21809209
64Hemiplegia (HP:0002301)2.19856702
65B lymphocytopenia (HP:0010976)2.19056118
66Abnormality of B cell number (HP:0010975)2.19056118
67Nephrogenic diabetes insipidus (HP:0009806)2.18059284
68Type I transferrin isoform profile (HP:0003642)2.17212851
69Atonic seizures (HP:0010819)2.15642143
70Thickened helices (HP:0000391)2.15163554
71Abnormal respiratory epithelium morphology (HP:0012253)2.13309600
72Abnormal respiratory motile cilium morphology (HP:0005938)2.13309600
73Type II lissencephaly (HP:0007260)2.12197993
74Methylmalonic acidemia (HP:0002912)2.11259930
75Congenital primary aphakia (HP:0007707)2.11234255
76Eczematoid dermatitis (HP:0000976)2.10928108
77Intestinal fistula (HP:0100819)2.09679743
78Abnormal rod and cone electroretinograms (HP:0008323)2.08508152
79Broad-based gait (HP:0002136)2.08235758
80Pancreatic islet-cell hyperplasia (HP:0004510)2.07531909
81Abnormal ciliary motility (HP:0012262)2.07079103
82Gait imbalance (HP:0002141)2.06900966
83Lip pit (HP:0100267)2.06244779
84Severe combined immunodeficiency (HP:0004430)2.05777370
85Bile duct proliferation (HP:0001408)2.05756385
86Abnormal biliary tract physiology (HP:0012439)2.05756385
87Stomatitis (HP:0010280)2.02897542
88Meningitis (HP:0001287)2.02613475
89Hyperventilation (HP:0002883)2.02489022
90Abnormality of the renal collecting system (HP:0004742)2.01870202
91Chronic sinusitis (HP:0011109)2.01751684
92Hemoptysis (HP:0002105)2.00990378
93Generalized hypopigmentation of hair (HP:0011358)2.00433598
94Panhypogammaglobulinemia (HP:0003139)1.99980744
95Neoplasm of the tracheobronchial system (HP:0100552)1.99817457
96Cupped ear (HP:0000378)1.99600515
97Chronic hepatic failure (HP:0100626)1.99233310
98Abnormality of male internal genitalia (HP:0000022)1.99220110
99IgG deficiency (HP:0004315)1.97734670
100Amelogenesis imperfecta (HP:0000705)1.97230553
101Focal motor seizures (HP:0011153)1.97105449
102Abnormality of incisor morphology (HP:0011063)1.95577406
103Combined immunodeficiency (HP:0005387)1.95233261
104Parakeratosis (HP:0001036)1.94937673
105Amyotrophic lateral sclerosis (HP:0007354)1.94122111
106Chronic diarrhea (HP:0002028)1.93623865
107Volvulus (HP:0002580)1.91936531
108Hypokalemic alkalosis (HP:0001949)1.90953993
109IgM deficiency (HP:0002850)1.89161408
110Neurofibrillary tangles (HP:0002185)1.88457817
111Type 2 muscle fiber atrophy (HP:0003554)1.88202491
112Flat occiput (HP:0005469)1.87919080
113Stomach cancer (HP:0012126)1.87872948
114Widely spaced teeth (HP:0000687)1.87453018
115Gastrointestinal atresia (HP:0002589)1.87087631
116Renal cortical cysts (HP:0000803)1.85604855
117Slow saccadic eye movements (HP:0000514)1.84850765
118Abnormality of the heme biosynthetic pathway (HP:0010472)1.84059358
119Pulmonary infiltrates (HP:0002113)1.83892647
120Alveolar cell carcinoma (HP:0006519)1.83413367
121Rectovaginal fistula (HP:0000143)1.82186177
122Rectal fistula (HP:0100590)1.82186177
123Vasculitis (HP:0002633)1.80977907
124Recurrent abscess formation (HP:0002722)1.80794084
125Nonprogressive disorder (HP:0003680)1.80610952
126Gastrointestinal infarctions (HP:0005244)1.80048631
127Agitation (HP:0000713)1.79948450
128Small hand (HP:0200055)1.77674687
129Chronic otitis media (HP:0000389)1.77653399
130Hypoproteinemia (HP:0003075)1.76914603
131Polydipsia (HP:0001959)1.76594786
132Abnormal drinking behavior (HP:0030082)1.76594786
133Abnormal respiratory motile cilium physiology (HP:0012261)1.76479388
134Vaginal atresia (HP:0000148)1.75732260
135Tented upper lip vermilion (HP:0010804)1.75646580
136Hypochromic microcytic anemia (HP:0004840)1.75234281
137Congenital stationary night blindness (HP:0007642)1.74890439
138Constricted visual fields (HP:0001133)1.74394886
139Hypomagnesemia (HP:0002917)1.73909822
140Cystic liver disease (HP:0006706)1.73706409
141True hermaphroditism (HP:0010459)1.73018251
142Broad nasal tip (HP:0000455)1.72994033
143Focal seizures (HP:0007359)1.72831196
144Genital tract atresia (HP:0001827)1.71963260
145Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.70988726
146Abnormal protein N-linked glycosylation (HP:0012347)1.70988726
147Abnormal protein glycosylation (HP:0012346)1.70988726
148Abnormal glycosylation (HP:0012345)1.70988726
149Abnormal auditory evoked potentials (HP:0006958)1.70660766
150Abolished electroretinogram (ERG) (HP:0000550)1.70212232
151Albinism (HP:0001022)1.69776574
152Recurrent bacterial skin infections (HP:0005406)1.67197383
153Dry hair (HP:0011359)1.67102678
154Coronal craniosynostosis (HP:0004440)1.66791895
155Agammaglobulinemia (HP:0004432)1.66448648
156Recurrent skin infections (HP:0001581)1.66086478
157Split foot (HP:0001839)1.66079164
158Intention tremor (HP:0002080)1.65892101
159Recurrent fungal infections (HP:0002841)1.65571384
160Poor coordination (HP:0002370)1.65197749
161Narrow nasal bridge (HP:0000446)1.63846255
162Median cleft lip (HP:0000161)1.63721268
163Poikiloderma (HP:0001029)1.63412994
164Decreased central vision (HP:0007663)1.63026122
165Peripheral hypomyelination (HP:0007182)1.62428234
166Retrobulbar optic neuritis (HP:0100654)1.62419598

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK4.46769959
2FRK4.16130942
3MAPK153.13796328
4CASK3.09042636
5ACVR1B2.91963188
6TAOK32.70492981
7MAP3K62.66689629
8PRPF4B2.63790372
9YES12.37016482
10OXSR12.07767363
11CAMKK22.05053800
12TXK2.02544009
13ICK1.84636284
14RIPK41.84077490
15STK391.82641181
16FGFR21.81903916
17FGR1.75296394
18NEK61.72124442
19IRAK41.64885660
20BMPR1B1.62277703
21BRD41.60927896
22CLK11.59470023
23TRPM71.58987129
24UHMK11.53861877
25KIT1.51266436
26MAP2K71.50608587
27ERBB31.49330079
28BLK1.48447705
29MAP4K21.44753806
30CDK191.41751229
31MUSK1.38536447
32EPHA31.38098325
33WNK31.37486809
34PIK3CG1.35531232
35MAPKAPK51.35292845
36MAPK131.31897324
37GRK61.27736923
38AKT31.24727306
39MATK1.24098624
40MAP3K141.21249002
41CSK1.21090012
42EPHA41.18871726
43BMPR21.16897253
44SGK2231.14922964
45SGK4941.14922964
46PAK31.13736302
47ZAK1.12798275
48MAP4K11.11973974
49JAK11.11114093
50CDK31.07597947
51FES1.06683923
52INSRR1.02075039
53IRAK11.01333868
54ITK0.99650732
55PKN10.98787660
56SGK20.96980614
57MARK30.96499904
58SIK20.95001189
59DDR20.92779938
60CSF1R0.90443800
61DAPK10.86580296
62TGFBR20.85638769
63CCNB10.84403529
64MARK20.83526348
65PRKD20.83255599
66JAK20.83036555
67TLK10.82749163
68TEC0.82039249
69TYK20.81625962
70BCR0.81463937
71CAMK2B0.80867921
72MST40.79708946
73CAMKK10.79301607
74IKBKE0.79096011
75PTK2B0.78826972
76STK110.77982932
77NLK0.77744999
78DYRK1A0.77280202
79LYN0.77118319
80TRIM280.76644166
81SIK30.76092755
82CSNK1A1L0.75556152
83JAK30.74941277
84LCK0.74043932
85HCK0.73312764
86TYRO30.71596585
87PINK10.71406208
88WNK40.71315876
89ADRBK20.69795808
90BTK0.69658513
91HIPK20.69619735
92GRK70.69446911
93STK38L0.69091378
94EPHB10.69086011
95CAMK2D0.68989750
96CHUK0.67897704
97MAP2K40.67640345
98CAMK40.67485440
99PIM10.66823980
100NTRK20.66517045
101CSNK1G10.66208533
102MAP2K60.64590657
103NTRK30.64521101
104NUAK10.64425373
105RPS6KB10.63862909
106TNK20.63172996
107ADRBK10.62717977
108IKBKB0.62628988
109BRSK20.61839467
110PLK20.61536843
111PIK3CA0.61009481
112MARK10.60596009
113FER0.59841215
114DAPK20.59564405
115EIF2AK30.58713792
116MAP3K40.58159483
117SYK0.57574457
118MAPK70.57467197
119SGK30.56628238
120PRKAA20.56381388
121PRKCQ0.55575857
122TGFBR10.54452013
123ZAP700.52398950
124VRK10.48874588
125CDC42BPA0.48152523
126GRK10.47050549
127CAMK2A0.46374987
128SGK10.45419539
129CSNK1G30.45306104
130WNK10.45305374
131MAPK40.45130101
132MAPK110.44640454
133DYRK1B0.44121181
134GSK3A0.43857234
135MKNK20.43586427
136MAP3K130.40490787
137RPS6KA60.37422571
138CAMK10.36096419
139MAP3K70.36072160
140CAMK2G0.35268301
141DYRK20.35063772
142OBSCN0.32568264
143CDK80.32332612
144PDGFRB0.31677956

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.75335061
2Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.18504593
3Primary immunodeficiency_Homo sapiens_hsa053403.13071392
4Fatty acid elongation_Homo sapiens_hsa000623.01727255
5Protein export_Homo sapiens_hsa030602.52813972
6Type I diabetes mellitus_Homo sapiens_hsa049402.21619499
7Steroid biosynthesis_Homo sapiens_hsa001002.19435552
8Fatty acid biosynthesis_Homo sapiens_hsa000612.13436077
9Circadian rhythm_Homo sapiens_hsa047102.02982339
10Asthma_Homo sapiens_hsa053101.99921953
11Regulation of autophagy_Homo sapiens_hsa041401.98455219
12Phototransduction_Homo sapiens_hsa047441.96808446
13Non-homologous end-joining_Homo sapiens_hsa034501.96323681
14SNARE interactions in vesicular transport_Homo sapiens_hsa041301.84203496
15Ether lipid metabolism_Homo sapiens_hsa005651.80572993
16Staphylococcus aureus infection_Homo sapiens_hsa051501.72800470
17Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.71907391
18Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.63142609
19Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.59880314
20Intestinal immune network for IgA production_Homo sapiens_hsa046721.59051143
21Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.57210666
22Morphine addiction_Homo sapiens_hsa050321.55389168
23Nicotine addiction_Homo sapiens_hsa050331.54994197
24Transcriptional misregulation in cancer_Homo sapiens_hsa052021.54266255
25Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.44274333
26Dorso-ventral axis formation_Homo sapiens_hsa043201.43366117
27Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.41489415
28Antigen processing and presentation_Homo sapiens_hsa046121.40086875
29Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.39344100
30Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.37066735
31Hematopoietic cell lineage_Homo sapiens_hsa046401.34982823
32ABC transporters_Homo sapiens_hsa020101.34543094
33Autoimmune thyroid disease_Homo sapiens_hsa053201.33460480
34Glutamatergic synapse_Homo sapiens_hsa047241.32930916
35Rheumatoid arthritis_Homo sapiens_hsa053231.27936885
36Olfactory transduction_Homo sapiens_hsa047401.26631024
37Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.25754969
38Nitrogen metabolism_Homo sapiens_hsa009101.24899774
39Tuberculosis_Homo sapiens_hsa051521.20864991
40GABAergic synapse_Homo sapiens_hsa047271.20771085
41Serotonergic synapse_Homo sapiens_hsa047261.19512643
42B cell receptor signaling pathway_Homo sapiens_hsa046621.18481335
43Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.17116975
44Circadian entrainment_Homo sapiens_hsa047131.14861248
45RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.14073588
46Sphingolipid metabolism_Homo sapiens_hsa006001.14065919
47NF-kappa B signaling pathway_Homo sapiens_hsa040641.09389601
48Fanconi anemia pathway_Homo sapiens_hsa034601.08668708
49Measles_Homo sapiens_hsa051621.04656598
50T cell receptor signaling pathway_Homo sapiens_hsa046601.03820733
51Maturity onset diabetes of the young_Homo sapiens_hsa049500.98130622
52Sulfur metabolism_Homo sapiens_hsa009200.97915460
53Axon guidance_Homo sapiens_hsa043600.96612727
54Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.92311277
55Notch signaling pathway_Homo sapiens_hsa043300.89622654
56Viral myocarditis_Homo sapiens_hsa054160.88881249
57Legionellosis_Homo sapiens_hsa051340.88032756
58NOD-like receptor signaling pathway_Homo sapiens_hsa046210.84936293
59Toxoplasmosis_Homo sapiens_hsa051450.84010695
60Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.83186542
61Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.82597569
62TNF signaling pathway_Homo sapiens_hsa046680.80898593
63Arachidonic acid metabolism_Homo sapiens_hsa005900.80168614
64Oxytocin signaling pathway_Homo sapiens_hsa049210.79239746
65FoxO signaling pathway_Homo sapiens_hsa040680.78164435
66Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.77793873
67Primary bile acid biosynthesis_Homo sapiens_hsa001200.76889964
68Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.76484327
69Allograft rejection_Homo sapiens_hsa053300.76266197
70Herpes simplex infection_Homo sapiens_hsa051680.75439264
71Insulin secretion_Homo sapiens_hsa049110.75314371
72Fatty acid metabolism_Homo sapiens_hsa012120.73134708
73Salivary secretion_Homo sapiens_hsa049700.72084585
74Base excision repair_Homo sapiens_hsa034100.70998676
75Influenza A_Homo sapiens_hsa051640.70414661
76Amphetamine addiction_Homo sapiens_hsa050310.70364315
77Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.69618520
78Long-term depression_Homo sapiens_hsa047300.69211365
79Platelet activation_Homo sapiens_hsa046110.68131656
80cAMP signaling pathway_Homo sapiens_hsa040240.67633023
81Steroid hormone biosynthesis_Homo sapiens_hsa001400.66759030
82alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.66657229
83Taste transduction_Homo sapiens_hsa047420.66523552
84Chemokine signaling pathway_Homo sapiens_hsa040620.66160973
85Type II diabetes mellitus_Homo sapiens_hsa049300.64829073
86Collecting duct acid secretion_Homo sapiens_hsa049660.64464206
87Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.64333636
88Butanoate metabolism_Homo sapiens_hsa006500.64135937
89Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.63623742
90Linoleic acid metabolism_Homo sapiens_hsa005910.61162519
91Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.60805262
92Phosphatidylinositol signaling system_Homo sapiens_hsa040700.60270674
93Vascular smooth muscle contraction_Homo sapiens_hsa042700.59093242
94Caffeine metabolism_Homo sapiens_hsa002320.59036430
95Toll-like receptor signaling pathway_Homo sapiens_hsa046200.58777517
96Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.58725714
97Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.58654234
98Other glycan degradation_Homo sapiens_hsa005110.56740336
99MAPK signaling pathway_Homo sapiens_hsa040100.56651550
100Carbohydrate digestion and absorption_Homo sapiens_hsa049730.55205637
101Calcium signaling pathway_Homo sapiens_hsa040200.55142927
102Wnt signaling pathway_Homo sapiens_hsa043100.54253914
103Leishmaniasis_Homo sapiens_hsa051400.53977846
104African trypanosomiasis_Homo sapiens_hsa051430.53004130
105Choline metabolism in cancer_Homo sapiens_hsa052310.52691822
106N-Glycan biosynthesis_Homo sapiens_hsa005100.52625297
107Mismatch repair_Homo sapiens_hsa034300.52216045
108Ras signaling pathway_Homo sapiens_hsa040140.52140308
109Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.51787806
110Prolactin signaling pathway_Homo sapiens_hsa049170.51423629
111Osteoclast differentiation_Homo sapiens_hsa043800.51208751
112Glycosaminoglycan degradation_Homo sapiens_hsa005310.51170494
113Ovarian steroidogenesis_Homo sapiens_hsa049130.50126866
114Malaria_Homo sapiens_hsa051440.49417628
115Phagosome_Homo sapiens_hsa041450.48514262
116Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.48282807
117Shigellosis_Homo sapiens_hsa051310.48059379
118Cocaine addiction_Homo sapiens_hsa050300.47839585
119Dopaminergic synapse_Homo sapiens_hsa047280.47548081
120Arginine and proline metabolism_Homo sapiens_hsa003300.47107104
121Gastric acid secretion_Homo sapiens_hsa049710.46138711
122Graft-versus-host disease_Homo sapiens_hsa053320.45528351
123RNA degradation_Homo sapiens_hsa030180.45425480
124Synaptic vesicle cycle_Homo sapiens_hsa047210.44672713
125Lysosome_Homo sapiens_hsa041420.44272801
126Aldosterone synthesis and secretion_Homo sapiens_hsa049250.44087692
127Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.44019210
128Cholinergic synapse_Homo sapiens_hsa047250.42865076
129Glycerophospholipid metabolism_Homo sapiens_hsa005640.42715023
130Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.39816405
131Jak-STAT signaling pathway_Homo sapiens_hsa046300.39787694
132ErbB signaling pathway_Homo sapiens_hsa040120.39174782
133Sphingolipid signaling pathway_Homo sapiens_hsa040710.38505979
134Lysine degradation_Homo sapiens_hsa003100.38077013
135Basal transcription factors_Homo sapiens_hsa030220.36621027
136Renin secretion_Homo sapiens_hsa049240.33044411
137Histidine metabolism_Homo sapiens_hsa003400.32955905

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