CLLU1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Expression of this gene has been shown to be upregulated in some individuals with chronic lymphocytic leukemia (CLL), and has been used for prognostic and diagnostic purposes. This gene was originally identified as a human-specific putative protein-coding gene due to the presence of a peptide (PAp00140670, HIIYSTFLSK) that could have supported translation at this locus. This peptide is not present in more recent builds of PeptideAtlas, and the presence of a protein product at this locus has not been independently verified. For this reason, this gene is being represented as non-coding. Sequence comparisons to other primates indicates that no other primate is predicted to contain an open reading frame. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)4.97259100
2regulation of cilium movement (GO:0003352)4.45817777
3detection of light stimulus involved in visual perception (GO:0050908)4.31817515
4detection of light stimulus involved in sensory perception (GO:0050962)4.31817515
5indole-containing compound catabolic process (GO:0042436)4.28654425
6indolalkylamine catabolic process (GO:0046218)4.28654425
7tryptophan catabolic process (GO:0006569)4.28654425
8L-fucose catabolic process (GO:0042355)4.23207946
9fucose catabolic process (GO:0019317)4.23207946
10L-fucose metabolic process (GO:0042354)4.23207946
11indolalkylamine metabolic process (GO:0006586)4.03869850
12detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.95549771
13epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.95315080
14response to pheromone (GO:0019236)3.83366583
15tryptophan metabolic process (GO:0006568)3.71634716
16kynurenine metabolic process (GO:0070189)3.62884638
17behavioral response to ethanol (GO:0048149)3.56089206
18cellular biogenic amine catabolic process (GO:0042402)3.42472555
19amine catabolic process (GO:0009310)3.42472555
20photoreceptor cell maintenance (GO:0045494)3.32885605
21cellular ketone body metabolic process (GO:0046950)3.30333286
22piRNA metabolic process (GO:0034587)3.26017404
23neural tube formation (GO:0001841)3.25764306
24epithelial cilium movement (GO:0003351)3.23403986
25protein K11-linked deubiquitination (GO:0035871)3.22626597
26reflex (GO:0060004)3.22379584
27regulation of memory T cell differentiation (GO:0043380)3.19132310
28water-soluble vitamin biosynthetic process (GO:0042364)3.13995178
29protein localization to cilium (GO:0061512)3.09429677
30axoneme assembly (GO:0035082)3.05384041
31preassembly of GPI anchor in ER membrane (GO:0016254)3.03574544
32indole-containing compound metabolic process (GO:0042430)3.03312317
33ketone body metabolic process (GO:1902224)3.03285093
34mannosylation (GO:0097502)3.00544731
35DNA deamination (GO:0045006)2.98812443
36negative regulation of mast cell activation (GO:0033004)2.97442610
37establishment of protein localization to Golgi (GO:0072600)2.96969518
38regulation of microtubule-based movement (GO:0060632)2.96374908
39negative regulation of cytosolic calcium ion concentration (GO:0051481)2.96181570
40cornea development in camera-type eye (GO:0061303)2.95511333
41polyol catabolic process (GO:0046174)2.94589039
42retinal cone cell development (GO:0046549)2.91388470
43neuronal action potential propagation (GO:0019227)2.86391299
44cilium morphogenesis (GO:0060271)2.84277763
45respiratory chain complex IV assembly (GO:0008535)2.83407747
46cilium movement (GO:0003341)2.78568636
47adenosine metabolic process (GO:0046085)2.78169849
48cAMP catabolic process (GO:0006198)2.76860059
49synaptic transmission, cholinergic (GO:0007271)2.76829760
50nonmotile primary cilium assembly (GO:0035058)2.73568018
51G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.73063719
52gamma-aminobutyric acid transport (GO:0015812)2.72453260
53anterograde synaptic vesicle transport (GO:0048490)2.68529155
54cyclic nucleotide catabolic process (GO:0009214)2.68020312
55signal peptide processing (GO:0006465)2.67645529
56multicellular organism reproduction (GO:0032504)2.66595030
57cilium organization (GO:0044782)2.66565594
58cilium or flagellum-dependent cell motility (GO:0001539)2.66336408
59proline transport (GO:0015824)2.65980114
60platelet dense granule organization (GO:0060155)2.65960363
61phosphatidylinositol acyl-chain remodeling (GO:0036149)2.64807287
62neuronal action potential (GO:0019228)2.63827439
63DNA methylation involved in gamete generation (GO:0043046)2.62591893
64dopamine transport (GO:0015872)2.62491396
65C4-dicarboxylate transport (GO:0015740)2.62481187
66regulation of hippo signaling (GO:0035330)2.60414174
67photoreceptor cell development (GO:0042461)2.60322381
68sphingoid metabolic process (GO:0046519)2.60321475
69detection of mechanical stimulus involved in sensory perception (GO:0050974)2.59012014
70regulation of action potential (GO:0098900)2.58367269
71positive regulation of prostaglandin secretion (GO:0032308)2.58049045
72cilium assembly (GO:0042384)2.57997675
73aromatic amino acid family catabolic process (GO:0009074)2.56733959
74regulation of neurotransmitter uptake (GO:0051580)2.56723396
75regulation of meiosis I (GO:0060631)2.55785142
76regulation of collateral sprouting (GO:0048670)2.55392219
77regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.53467594
78primary amino compound metabolic process (GO:1901160)2.52226201
79transmission of nerve impulse (GO:0019226)2.50390029
80benzene-containing compound metabolic process (GO:0042537)2.49011206
81sulfation (GO:0051923)2.48715262
82inositol phosphate catabolic process (GO:0071545)2.48563688
83rhodopsin mediated signaling pathway (GO:0016056)2.48497454
84glycerophospholipid catabolic process (GO:0046475)2.48303483
85auditory receptor cell stereocilium organization (GO:0060088)2.48035940
86RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.47281324
87protein targeting to Golgi (GO:0000042)2.46760240
88DNA double-strand break processing (GO:0000729)2.46696223
89intraciliary transport (GO:0042073)2.46204620
90cytochrome complex assembly (GO:0017004)2.45379456
91transepithelial transport (GO:0070633)2.41536064
92positive regulation of fatty acid transport (GO:2000193)2.41066841
93recombinational repair (GO:0000725)2.41058880
94double-strand break repair via homologous recombination (GO:0000724)2.40879914
95cellular response to sterol (GO:0036315)2.40227109
96glycosphingolipid biosynthetic process (GO:0006688)2.39735037
97sex differentiation (GO:0007548)2.39355316
98GPI anchor metabolic process (GO:0006505)2.39135848
99regulation of rhodopsin mediated signaling pathway (GO:0022400)2.38903924
100replication fork processing (GO:0031297)2.38753717

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.58679037
2ZNF274_21170338_ChIP-Seq_K562_Hela3.53057764
3VDR_22108803_ChIP-Seq_LS180_Human3.03340272
4IGF1R_20145208_ChIP-Seq_DFB_Human2.88461464
5ZFP57_27257070_Chip-Seq_ESCs_Mouse2.80957620
6POU3F2_20337985_ChIP-ChIP_501MEL_Human2.74034057
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.63259077
8FLI1_27457419_Chip-Seq_LIVER_Mouse2.44983812
9CTBP2_25329375_ChIP-Seq_LNCAP_Human2.40277579
10TAF15_26573619_Chip-Seq_HEK293_Human2.37336923
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.26067431
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.14465536
13P300_19829295_ChIP-Seq_ESCs_Human2.13169123
14FUS_26573619_Chip-Seq_HEK293_Human2.11044860
15CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.07681231
16PCGF2_27294783_Chip-Seq_ESCs_Mouse2.03210165
17CTBP1_25329375_ChIP-Seq_LNCAP_Human2.03035634
18ER_23166858_ChIP-Seq_MCF-7_Human1.97945665
19EZH2_22144423_ChIP-Seq_EOC_Human1.94907352
20EWS_26573619_Chip-Seq_HEK293_Human1.91185680
21AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.90083171
22SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.81855432
23BCAT_22108803_ChIP-Seq_LS180_Human1.78534591
24SMAD4_21799915_ChIP-Seq_A2780_Human1.73501602
25UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.73041129
26STAT3_23295773_ChIP-Seq_U87_Human1.69688130
27CBP_20019798_ChIP-Seq_JUKART_Human1.67302876
28IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.67302876
29* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.66068600
30SUZ12_27294783_Chip-Seq_NPCs_Mouse1.65552331
31PIAS1_25552417_ChIP-Seq_VCAP_Human1.65235056
32MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.60514711
33EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.58345861
34PCGF2_27294783_Chip-Seq_NPCs_Mouse1.57431638
35EZH2_27294783_Chip-Seq_NPCs_Mouse1.57216792
36TCF4_23295773_ChIP-Seq_U87_Human1.56630110
37* AR_25329375_ChIP-Seq_VCAP_Human1.55577227
38NR3C1_21868756_ChIP-Seq_MCF10A_Human1.54653787
39HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.52479050
40NFE2_27457419_Chip-Seq_LIVER_Mouse1.51074228
41SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.49405540
42MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.48967882
43TP53_22573176_ChIP-Seq_HFKS_Human1.48950375
44TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.48045439
45SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.45491230
46MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.42442903
47TCF4_22108803_ChIP-Seq_LS180_Human1.41170596
48NOTCH1_21737748_ChIP-Seq_TLL_Human1.38668779
49SMAD3_21741376_ChIP-Seq_EPCs_Human1.38270082
50OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37616045
51NANOG_18555785_Chip-Seq_ESCs_Mouse1.36882565
52FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.36348944
53BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.35602793
54KLF5_20875108_ChIP-Seq_MESCs_Mouse1.35441935
55IRF1_19129219_ChIP-ChIP_H3396_Human1.35256189
56TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.35161546
57RUNX2_22187159_ChIP-Seq_PCA_Human1.34676026
58SOX2_19829295_ChIP-Seq_ESCs_Human1.34487098
59NANOG_19829295_ChIP-Seq_ESCs_Human1.34487098
60CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.34233033
61TOP2B_26459242_ChIP-Seq_MCF-7_Human1.34124512
62CRX_20693478_ChIP-Seq_RETINA_Mouse1.30894835
63TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30702688
64POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.30702688
65EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.29993977
66SMAD4_21741376_ChIP-Seq_EPCs_Human1.28256037
67EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.27418724
68FLI1_21867929_ChIP-Seq_TH2_Mouse1.26540584
69* PRDM14_20953172_ChIP-Seq_ESCs_Human1.24839955
70P53_22387025_ChIP-Seq_ESCs_Mouse1.23139026
71FOXA1_21572438_ChIP-Seq_LNCaP_Human1.22805911
72REST_21632747_ChIP-Seq_MESCs_Mouse1.22614130
73GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.17908193
74* CDX2_22108803_ChIP-Seq_LS180_Human1.17027175
75FOXA1_25329375_ChIP-Seq_VCAP_Human1.15136538
76FOXA1_27270436_Chip-Seq_PROSTATE_Human1.15136538
77E2F1_18555785_Chip-Seq_ESCs_Mouse1.15050126
78STAT3_18555785_Chip-Seq_ESCs_Mouse1.14875717
79OCT4_21477851_ChIP-Seq_ESCs_Mouse1.11589228
80SUZ12_18555785_Chip-Seq_ESCs_Mouse1.09417068
81* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09338711
82SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.09039891
83TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.08450164
84ETV2_25802403_ChIP-Seq_MESCs_Mouse1.07628515
85CMYC_18555785_Chip-Seq_ESCs_Mouse1.07023124
86MYC_18940864_ChIP-ChIP_HL60_Human1.06672645
87NCOR_22424771_ChIP-Seq_293T_Human1.05439792
88P300_18555785_Chip-Seq_ESCs_Mouse1.05369061
89HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.04973415
90TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.03445506
91AR_20517297_ChIP-Seq_VCAP_Human1.03197212
92TAL1_26923725_Chip-Seq_HPCs_Mouse1.02360213
93TP53_16413492_ChIP-PET_HCT116_Human1.01616743
94EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.00796172
95RNF2_27304074_Chip-Seq_NSC_Mouse1.00372338
96BMI1_23680149_ChIP-Seq_NPCS_Mouse0.98869490
97AR_21572438_ChIP-Seq_LNCaP_Human0.97067528
98GATA3_21878914_ChIP-Seq_MCF-7_Human0.96471587
99SOX2_21211035_ChIP-Seq_LN229_Gbm0.96199209
100E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.96061460

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003195_calcinosis3.21813803
2MP0000569_abnormal_digit_pigmentation3.10497460
3MP0002102_abnormal_ear_morphology3.08994577
4MP0005551_abnormal_eye_electrophysiolog2.76141690
5MP0008877_abnormal_DNA_methylation2.73003537
6MP0001968_abnormal_touch/_nociception2.64934890
7MP0010386_abnormal_urinary_bladder2.31412312
8MP0002837_dystrophic_cardiac_calcinosis2.27399085
9MP0003880_abnormal_central_pattern2.19052173
10MP0006072_abnormal_retinal_apoptosis2.17385937
11MP0002736_abnormal_nociception_after2.15765186
12MP0002638_abnormal_pupillary_reflex2.13769856
13MP0000372_irregular_coat_pigmentation2.13352147
14MP0003787_abnormal_imprinting2.12502799
15MP0002876_abnormal_thyroid_physiology2.11756956
16MP0004043_abnormal_pH_regulation2.07155151
17MP0009046_muscle_twitch2.06857365
18MP0005253_abnormal_eye_physiology2.06664076
19MP0001501_abnormal_sleep_pattern2.04225443
20MP0003011_delayed_dark_adaptation1.99871898
21MP0009745_abnormal_behavioral_response1.90389880
22MP0005646_abnormal_pituitary_gland1.83256941
23MP0000427_abnormal_hair_cycle1.79207560
24MP0006276_abnormal_autonomic_nervous1.71462399
25MP0002272_abnormal_nervous_system1.67761510
26MP0008872_abnormal_physiological_respon1.58056325
27MP0002909_abnormal_adrenal_gland1.54634022
28MP0002138_abnormal_hepatobiliary_system1.53692159
29MP0003252_abnormal_bile_duct1.51345223
30MP0001984_abnormal_olfaction1.49286142
31MP0003136_yellow_coat_color1.48644676
32MP0003646_muscle_fatigue1.47974605
33MP0002938_white_spotting1.47262950
34MP0005645_abnormal_hypothalamus_physiol1.45058373
35MP0000631_abnormal_neuroendocrine_gland1.38581783
36MP0001986_abnormal_taste_sensitivity1.38374109
37MP0002254_reproductive_system_inflammat1.34712279
38MP0008875_abnormal_xenobiotic_pharmacok1.29190291
39MP0005379_endocrine/exocrine_gland_phen1.28842403
40MP0000383_abnormal_hair_follicle1.25627801
41MP0005075_abnormal_melanosome_morpholog1.25419053
42MP0004885_abnormal_endolymph1.24636470
43MP0001485_abnormal_pinna_reflex1.23764897
44MP0004142_abnormal_muscle_tone1.22010433
45MP0001486_abnormal_startle_reflex1.21348771
46MP0002064_seizures1.19817926
47MP0002163_abnormal_gland_morphology1.19235318
48MP0002928_abnormal_bile_duct1.19132451
49MP0005410_abnormal_fertilization1.19006535
50MP0002653_abnormal_ependyma_morphology1.18889546
51MP0002557_abnormal_social/conspecific_i1.16958784
52MP0002572_abnormal_emotion/affect_behav1.16517260
53MP0005174_abnormal_tail_pigmentation1.16457919
54MP0008058_abnormal_DNA_repair1.14923594
55MP0005085_abnormal_gallbladder_physiolo1.14389325
56MP0005084_abnormal_gallbladder_morpholo1.14164006
57MP0002733_abnormal_thermal_nociception1.12543162
58MP0001970_abnormal_pain_threshold1.12030476
59MP0001764_abnormal_homeostasis1.11914493
60MP0004924_abnormal_behavior1.10583099
61MP0005386_behavior/neurological_phenoty1.10583099
62MP0000538_abnormal_urinary_bladder1.10201694
63MP0002735_abnormal_chemical_nociception1.09068642
64MP0002234_abnormal_pharynx_morphology1.04767323
65MP0002693_abnormal_pancreas_physiology1.03818171
66MP0002751_abnormal_autonomic_nervous1.02636400
67MP0003121_genomic_imprinting1.01574646
68MP0002067_abnormal_sensory_capabilities0.99182319
69MP0003718_maternal_effect0.96723583
70MP0005310_abnormal_salivary_gland0.96347124
71MP0003635_abnormal_synaptic_transmissio0.94568434
72MP0004215_abnormal_myocardial_fiber0.94474951
73MP0000613_abnormal_salivary_gland0.93086595
74MP0003950_abnormal_plasma_membrane0.92893128
75MP0004147_increased_porphyrin_level0.91654659
76MP0001529_abnormal_vocalization0.91650299
77MP0002063_abnormal_learning/memory/cond0.90602929
78MP0003698_abnormal_male_reproductive0.89669908
79MP0000230_abnormal_systemic_arterial0.89422912
80MP0001324_abnormal_eye_pigmentation0.88526976
81MP0002229_neurodegeneration0.87085751
82MP0009780_abnormal_chondrocyte_physiolo0.86632000
83MP0002160_abnormal_reproductive_system0.85858309
84MP0006054_spinal_hemorrhage0.85842740
85MP0005195_abnormal_posterior_eye0.84747829
86MP0000647_abnormal_sebaceous_gland0.84658136
87MP0000371_diluted_coat_color0.84636288
88MP0004133_heterotaxia0.84468812
89MP0005332_abnormal_amino_acid0.83989584
90MP0005389_reproductive_system_phenotype0.81914129
91MP0005171_absent_coat_pigmentation0.81463249
92MP0005167_abnormal_blood-brain_barrier0.79172940
93MP0000015_abnormal_ear_pigmentation0.78750416
94MP0008775_abnormal_heart_ventricle0.78423508
95MP0004145_abnormal_muscle_electrophysio0.78081661
96MP0002095_abnormal_skin_pigmentation0.77987663
97MP0002752_abnormal_somatic_nervous0.76907066
98MP0005187_abnormal_penis_morphology0.76629619
99MP0002090_abnormal_vision0.76263212
100MP0002734_abnormal_mechanical_nocicepti0.75792302

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.49241352
2Congenital stationary night blindness (HP:0007642)4.05095855
3Molar tooth sign on MRI (HP:0002419)3.92917039
4Abnormality of midbrain morphology (HP:0002418)3.92917039
5Nephronophthisis (HP:0000090)3.81227895
6Pancreatic fibrosis (HP:0100732)3.80091682
7True hermaphroditism (HP:0010459)3.76169035
8Hyperventilation (HP:0002883)3.49387259
9Gaze-evoked nystagmus (HP:0000640)3.48409073
10Abnormality of the renal cortex (HP:0011035)3.40428920
11Medial flaring of the eyebrow (HP:0010747)3.39992508
12Abnormality of the renal medulla (HP:0100957)3.26520956
13Attenuation of retinal blood vessels (HP:0007843)2.99519055
14Renal cortical cysts (HP:0000803)2.93507292
15Abnormal rod and cone electroretinograms (HP:0008323)2.79917080
16Febrile seizures (HP:0002373)2.76655404
17Cystic liver disease (HP:0006706)2.76165792
18Inability to walk (HP:0002540)2.71490314
19Gait imbalance (HP:0002141)2.69219324
20Progressive cerebellar ataxia (HP:0002073)2.65013808
21Abnormality of macular pigmentation (HP:0008002)2.65010770
22Progressive inability to walk (HP:0002505)2.64584802
23Pendular nystagmus (HP:0012043)2.63553669
24Congenital primary aphakia (HP:0007707)2.61825741
25Tubular atrophy (HP:0000092)2.57412871
26Chronic hepatic failure (HP:0100626)2.57018209
27Abolished electroretinogram (ERG) (HP:0000550)2.56108025
28Dynein arm defect of respiratory motile cilia (HP:0012255)2.49128321
29Absent/shortened dynein arms (HP:0200106)2.49128321
30Hypothermia (HP:0002045)2.46865455
31Genetic anticipation (HP:0003743)2.46770064
32Nephrogenic diabetes insipidus (HP:0009806)2.41663689
33Absent speech (HP:0001344)2.36843498
34Type II lissencephaly (HP:0007260)2.35358044
35Focal motor seizures (HP:0011153)2.35078884
36Focal seizures (HP:0007359)2.33813633
37Broad-based gait (HP:0002136)2.32773049
38Severe visual impairment (HP:0001141)2.29221574
39Bony spicule pigmentary retinopathy (HP:0007737)2.27931854
40Aplasia/Hypoplasia of the fovea (HP:0008060)2.24723500
41Hypoplasia of the fovea (HP:0007750)2.24723500
42Sclerocornea (HP:0000647)2.24593005
43Large for gestational age (HP:0001520)2.23723240
44Abnormal drinking behavior (HP:0030082)2.22863464
45Polydipsia (HP:0001959)2.22863464
46Keratoconus (HP:0000563)2.16885748
47Increased corneal curvature (HP:0100692)2.16885748
48Genital tract atresia (HP:0001827)2.16229856
49Fair hair (HP:0002286)2.15467158
50Dialeptic seizures (HP:0011146)2.15346944
51Lissencephaly (HP:0001339)2.11459629
52Volvulus (HP:0002580)2.10476231
53Aplasia/Hypoplasia of the tongue (HP:0010295)2.09180855
54Widely spaced teeth (HP:0000687)2.08811608
55Furrowed tongue (HP:0000221)2.08252234
56Vaginal atresia (HP:0000148)2.06817649
57Methylmalonic acidemia (HP:0002912)2.05769080
58Abnormal ciliary motility (HP:0012262)2.04920418
59Abnormal respiratory epithelium morphology (HP:0012253)2.04392978
60Abnormal respiratory motile cilium morphology (HP:0005938)2.04392978
61Aplasia/Hypoplasia of the spleen (HP:0010451)2.03703333
62Methylmalonic aciduria (HP:0012120)2.03003200
63Constricted visual fields (HP:0001133)2.02711059
64Proximal tubulopathy (HP:0000114)1.99101362
65Hemiparesis (HP:0001269)1.98924088
66Decreased electroretinogram (ERG) amplitude (HP:0000654)1.98586268
67Ketoacidosis (HP:0001993)1.98273434
68Abnormal biliary tract physiology (HP:0012439)1.97012462
69Bile duct proliferation (HP:0001408)1.97012462
70Congenital hepatic fibrosis (HP:0002612)1.96520856
71Severe muscular hypotonia (HP:0006829)1.95994451
72Decreased central vision (HP:0007663)1.95915449
73Aplasia/Hypoplasia of the tibia (HP:0005772)1.93683083
74Abnormality of the labia minora (HP:0012880)1.93130163
75Pachygyria (HP:0001302)1.93070327
76Abnormality of the fovea (HP:0000493)1.92258338
77Protruding tongue (HP:0010808)1.90994378
78Central scotoma (HP:0000603)1.90889158
79Polyuria (HP:0000103)1.90814726
80Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.90670838
81Abnormality of alanine metabolism (HP:0010916)1.90670838
82Hyperalaninemia (HP:0003348)1.90670838
83Congenital sensorineural hearing impairment (HP:0008527)1.89501201
84Asplenia (HP:0001746)1.87627446
85Intestinal atresia (HP:0011100)1.87096807
86Poor coordination (HP:0002370)1.82454944
87Stomach cancer (HP:0012126)1.82436257
88Retinitis pigmentosa (HP:0000510)1.80288008
89Male pseudohermaphroditism (HP:0000037)1.80194815
90Ketosis (HP:0001946)1.80156564
91Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.79880853
92Anencephaly (HP:0002323)1.78036653
93Albinism (HP:0001022)1.77583842
94Absence seizures (HP:0002121)1.76004229
95Colon cancer (HP:0003003)1.75284377
96Oculomotor apraxia (HP:0000657)1.74899176
97Postaxial foot polydactyly (HP:0001830)1.71636271
98Hypoalbuminemia (HP:0003073)1.71324158
99Abnormal albumin level (HP:0012116)1.71324158
100Abnormal respiratory motile cilium physiology (HP:0012261)1.70948967

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.72928104
2ADRBK23.04924933
3NEK13.02885815
4WNK32.75040281
5GRK12.68220727
6NUAK12.63176596
7MAP4K22.50292583
8BMPR1B2.38930532
9TRIM282.13720725
10ACVR1B2.11928033
11ZAK2.11732760
12MAPK131.97934446
13OXSR11.92446078
14TAOK31.91990461
15PINK11.76837706
16TNIK1.74352263
17CASK1.64820790
18MAP3K41.62047737
19AKT31.59517066
20BCR1.53446347
21INSRR1.46971663
22STK391.40191862
23PAK31.34036568
24EIF2AK31.27372249
25TXK1.20969679
26DAPK21.15274143
27MKNK21.13930153
28NTRK31.11067128
29PLK21.10042527
30WNK41.05760623
31PRKCE1.03833187
32PRKCG1.02977677
33PTK2B1.01695160
34ADRBK11.01535450
35MARK11.00900245
36MAP2K70.99939496
37STK38L0.99663453
38PIK3CG0.94032229
39ERBB30.91317365
40TAF10.91230021
41NEK20.88107054
42PLK40.84496738
43CSNK1G10.84015298
44FER0.82429699
45MST40.80878940
46TEC0.80460581
47TLK10.79760393
48CSNK1G20.76978688
49MUSK0.76772122
50LATS10.75803384
51TNK20.73839171
52TIE10.73084133
53FGFR20.72548748
54NLK0.69083193
55CSNK1G30.68474901
56PHKG10.66077750
57PHKG20.66077750
58CAMKK20.65299847
59TGFBR10.62674260
60DYRK20.61783360
61EPHA40.61498949
62PNCK0.60245428
63CAMK2A0.59959781
64STK30.59459950
65PRKCI0.53391051
66BCKDK0.52520106
67CDK190.52087236
68CSNK1A1L0.51976964
69MAP2K60.50084567
70PRKCQ0.47669771
71CSNK1A10.46245007
72PDK20.45874024
73STK160.45637774
74NME10.44211951
75SIK20.44180927
76BRSK20.43572713
77PIK3CA0.41371953
78IRAK10.41054497
79PRKACA0.40403835
80SGK20.38935672
81VRK10.37725555
82MKNK10.37225139
83PLK30.36666770
84CSNK1D0.36017854
85PRKACB0.35444381
86PKN10.35337277
87CDK30.35067259
88IKBKB0.33030147
89STK110.32952796
90WEE10.31601892
91PRKAA20.31558463
92PRKG10.31330769
93DYRK30.30171095
94PRKAA10.28170351
95CCNB10.27889545
96PRKCA0.27116924
97ABL10.26424824
98DYRK1A0.26399706
99MAPKAPK50.26126245
100ATM0.25950733

Predicted pathways (KEGG)

RankGene SetZ-score
1Butanoate metabolism_Homo sapiens_hsa006503.00392480
2Phototransduction_Homo sapiens_hsa047442.82049224
3alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.66369807
4Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.59731913
5Linoleic acid metabolism_Homo sapiens_hsa005912.55094546
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.49347602
7Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.43737080
8Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.42744866
9Maturity onset diabetes of the young_Homo sapiens_hsa049502.33972976
10Nitrogen metabolism_Homo sapiens_hsa009102.27367904
11Ether lipid metabolism_Homo sapiens_hsa005652.23356979
12Primary bile acid biosynthesis_Homo sapiens_hsa001202.11586904
13Nicotine addiction_Homo sapiens_hsa050331.99717967
14Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.89663384
15Propanoate metabolism_Homo sapiens_hsa006401.89571046
16Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.87866954
17Tryptophan metabolism_Homo sapiens_hsa003801.83339454
18Homologous recombination_Homo sapiens_hsa034401.77271308
19Selenocompound metabolism_Homo sapiens_hsa004501.76950574
20Regulation of autophagy_Homo sapiens_hsa041401.74626476
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.70343574
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.65455253
23Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.58723166
24Taste transduction_Homo sapiens_hsa047421.55652376
25Basal transcription factors_Homo sapiens_hsa030221.48580216
26Caffeine metabolism_Homo sapiens_hsa002321.39165973
27Protein export_Homo sapiens_hsa030601.37325211
28Olfactory transduction_Homo sapiens_hsa047401.35302262
29Fanconi anemia pathway_Homo sapiens_hsa034601.34868960
30Steroid hormone biosynthesis_Homo sapiens_hsa001401.34165271
31Non-homologous end-joining_Homo sapiens_hsa034501.31315712
32Morphine addiction_Homo sapiens_hsa050321.26510423
33Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.22946315
34Insulin secretion_Homo sapiens_hsa049111.20551449
35Retinol metabolism_Homo sapiens_hsa008301.19689082
36Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.19448915
37Peroxisome_Homo sapiens_hsa041461.11466716
38ABC transporters_Homo sapiens_hsa020101.10493520
39Sphingolipid metabolism_Homo sapiens_hsa006001.09848994
40Circadian entrainment_Homo sapiens_hsa047131.08419100
41Arachidonic acid metabolism_Homo sapiens_hsa005901.08277032
42Chemical carcinogenesis_Homo sapiens_hsa052041.06820785
43beta-Alanine metabolism_Homo sapiens_hsa004101.00097869
44Glutamatergic synapse_Homo sapiens_hsa047240.98206076
45RNA degradation_Homo sapiens_hsa030180.96674022
46Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.93751028
47RNA polymerase_Homo sapiens_hsa030200.92621463
48Oxidative phosphorylation_Homo sapiens_hsa001900.90749894
49Serotonergic synapse_Homo sapiens_hsa047260.89442908
50Intestinal immune network for IgA production_Homo sapiens_hsa046720.89413049
51One carbon pool by folate_Homo sapiens_hsa006700.88868956
52Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.88804311
53Fatty acid elongation_Homo sapiens_hsa000620.87822642
54GABAergic synapse_Homo sapiens_hsa047270.87755259
55Salivary secretion_Homo sapiens_hsa049700.87579085
56Fatty acid metabolism_Homo sapiens_hsa012120.84714327
57Sulfur metabolism_Homo sapiens_hsa009200.84452822
58Ovarian steroidogenesis_Homo sapiens_hsa049130.80459578
59Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.78938642
60Purine metabolism_Homo sapiens_hsa002300.76233155
61Fatty acid degradation_Homo sapiens_hsa000710.74596335
62Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.73876072
63Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.73314166
64Calcium signaling pathway_Homo sapiens_hsa040200.73105035
65Pentose and glucuronate interconversions_Homo sapiens_hsa000400.71612617
66Fat digestion and absorption_Homo sapiens_hsa049750.70414954
67Glycerolipid metabolism_Homo sapiens_hsa005610.69728039
68Dorso-ventral axis formation_Homo sapiens_hsa043200.69554046
69Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.68947980
70Circadian rhythm_Homo sapiens_hsa047100.68652648
71Fatty acid biosynthesis_Homo sapiens_hsa000610.65072970
72Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.64803025
73Primary immunodeficiency_Homo sapiens_hsa053400.64512351
74Glycerophospholipid metabolism_Homo sapiens_hsa005640.62369079
75Metabolic pathways_Homo sapiens_hsa011000.61596998
76Collecting duct acid secretion_Homo sapiens_hsa049660.61040998
77Long-term depression_Homo sapiens_hsa047300.59799259
78Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.58690144
79Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.55187478
80Dopaminergic synapse_Homo sapiens_hsa047280.54227405
81Parkinsons disease_Homo sapiens_hsa050120.52751661
82SNARE interactions in vesicular transport_Homo sapiens_hsa041300.51740817
83Type I diabetes mellitus_Homo sapiens_hsa049400.49689279
84Amphetamine addiction_Homo sapiens_hsa050310.47333822
85Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.47032947
86Steroid biosynthesis_Homo sapiens_hsa001000.44887107
87Cyanoamino acid metabolism_Homo sapiens_hsa004600.43726496
88N-Glycan biosynthesis_Homo sapiens_hsa005100.42286551
89Cocaine addiction_Homo sapiens_hsa050300.41851994
90Vascular smooth muscle contraction_Homo sapiens_hsa042700.41633860
91cAMP signaling pathway_Homo sapiens_hsa040240.40989694
92Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.40888758
93Histidine metabolism_Homo sapiens_hsa003400.38477216
94Pancreatic secretion_Homo sapiens_hsa049720.37640673
95Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.37269164
96Pyrimidine metabolism_Homo sapiens_hsa002400.37143554
97Huntingtons disease_Homo sapiens_hsa050160.33706334
98Renin secretion_Homo sapiens_hsa049240.33544136
99Mineral absorption_Homo sapiens_hsa049780.31998604
100Cysteine and methionine metabolism_Homo sapiens_hsa002700.29640295

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