CLLU1OS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of T-helper 1 cell differentiation (GO:0045625)4.93301457
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.83090879
3positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)4.82736495
4regulation of vitamin D biosynthetic process (GO:0060556)4.68929025
5positive regulation of gamma-delta T cell activation (GO:0046645)4.64262245
6type I interferon signaling pathway (GO:0060337)4.55689843
7cellular response to type I interferon (GO:0071357)4.55689843
8response to type I interferon (GO:0034340)4.53761303
9detection of bacterium (GO:0016045)4.51417243
10regulation of vitamin metabolic process (GO:0030656)4.50557729
11T-helper 1 type immune response (GO:0042088)4.50548510
12regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.40206135
13detection of other organism (GO:0098543)4.39948910
14peptidyl-tyrosine autophosphorylation (GO:0038083)4.33510934
15regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)4.30098542
16positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.27703384
17myeloid dendritic cell differentiation (GO:0043011)4.21422480
18defense response to protozoan (GO:0042832)4.21025381
19NIK/NF-kappaB signaling (GO:0038061)4.14540286
20positive regulation of T-helper cell differentiation (GO:0045624)4.14520840
21response to protozoan (GO:0001562)4.07764164
22positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.99174075
23negative regulation of interleukin-12 production (GO:0032695)3.93272499
24regulation of T-helper cell differentiation (GO:0045622)3.91381373
25regulation of antigen processing and presentation (GO:0002577)3.85043290
26oligosaccharide catabolic process (GO:0009313)3.83749309
27interferon-gamma-mediated signaling pathway (GO:0060333)3.82879882
28regulation of interferon-alpha production (GO:0032647)3.79759470
29immunoglobulin mediated immune response (GO:0016064)3.78426768
30myeloid dendritic cell activation (GO:0001773)3.74530498
31regulation of natural killer cell differentiation (GO:0032823)3.69911593
32regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.65647447
33positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.64659186
34glycosphingolipid catabolic process (GO:0046479)3.62518351
35regulation of cytokine secretion involved in immune response (GO:0002739)3.60061009
36response to peptidoglycan (GO:0032494)3.58353053
37phosphate ion transport (GO:0006817)3.57210430
38CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.53900508
39positive regulation of type 2 immune response (GO:0002830)3.52297247
40lipopolysaccharide-mediated signaling pathway (GO:0031663)3.51225585
41regulation of natural killer cell activation (GO:0032814)3.50870443
42positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.45709846
43regulation of chronic inflammatory response (GO:0002676)3.45117730
44macrophage activation involved in immune response (GO:0002281)3.42574894
45regulation of interferon-gamma biosynthetic process (GO:0045072)3.38317634
46positive regulation of interferon-alpha production (GO:0032727)3.37060662
47dendritic cell differentiation (GO:0097028)3.36226995
48regulation of dendritic cell antigen processing and presentation (GO:0002604)3.34892111
49positive regulation of interleukin-17 production (GO:0032740)3.34487794
50positive regulation of heat generation (GO:0031652)3.32959044
51detection of external biotic stimulus (GO:0098581)3.31697818
52regulation of fever generation (GO:0031620)3.31633251
53positive regulation of defense response to virus by host (GO:0002230)3.31155001
54regulation of B cell receptor signaling pathway (GO:0050855)3.28845097
55glycolipid catabolic process (GO:0019377)3.24844038
56regulation of interleukin-12 production (GO:0032655)3.17622312
57positive regulation of antigen processing and presentation (GO:0002579)3.17607409
58regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)3.17034779
59positive regulation of NF-kappaB import into nucleus (GO:0042346)3.15949918
60response to thyroid hormone (GO:0097066)3.15515359
61positive regulation of interleukin-12 production (GO:0032735)3.12999016
62negative regulation of myeloid cell apoptotic process (GO:0033033)3.12328637
63cellular response to interferon-gamma (GO:0071346)3.11646687
64negative regulation of viral genome replication (GO:0045071)3.10101239
65positive regulation of humoral immune response (GO:0002922)3.09341269
66regulation of gamma-delta T cell activation (GO:0046643)3.09067465
67fat-soluble vitamin biosynthetic process (GO:0042362)3.08026447
68histone H2A acetylation (GO:0043968)3.07679081
69energy homeostasis (GO:0097009)3.06367771
70positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.03719257
71positive regulation of uterine smooth muscle contraction (GO:0070474)3.03625489
72positive regulation of chemokine biosynthetic process (GO:0045080)3.00912204
73urate metabolic process (GO:0046415)3.00788782
74T cell migration (GO:0072678)3.00008631
75regulation of interleukin-2 biosynthetic process (GO:0045076)2.98619340
76response to interferon-gamma (GO:0034341)2.96972263
77detection of biotic stimulus (GO:0009595)2.94050687
78negative regulation of nitric oxide biosynthetic process (GO:0045019)2.93645628
79positive regulation by symbiont of host defense response (GO:0052509)2.93267698
80modulation by symbiont of host defense response (GO:0052031)2.93267698
81modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.93267698
82modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.93267698
83positive regulation by organism of defense response of other organism involved in symbiotic interact2.93267698
84modulation by symbiont of host immune response (GO:0052553)2.93267698
85positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.93258569
86B cell mediated immunity (GO:0019724)2.91855171
87positive regulation of B cell differentiation (GO:0045579)2.90332187
88regulation of interferon-beta biosynthetic process (GO:0045357)2.88120964
89positive regulation of natural killer cell activation (GO:0032816)2.88007742
90positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.87369327
91ceramide catabolic process (GO:0046514)2.86859287
92negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.86595462
93negative regulation of cytokine production involved in immune response (GO:0002719)2.83819940
94regulation of podosome assembly (GO:0071801)2.83649112
95regulation of T-helper 1 type immune response (GO:0002825)2.81643004
96regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.78516642
97mature B cell differentiation involved in immune response (GO:0002313)2.78142787
98monocyte chemotaxis (GO:0002548)2.77151673
99regulation of alpha-beta T cell proliferation (GO:0046640)2.74789955
100positive regulation of interleukin-10 production (GO:0032733)2.73341820

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human7.63365284
2IRF8_21731497_ChIP-ChIP_J774_Mouse5.40548953
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.99918407
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.74300382
5IRF8_27001747_Chip-Seq_BMDM_Mouse3.64770505
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.44714840
7RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.94539785
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.93979487
9BP1_19119308_ChIP-ChIP_Hs578T_Human2.93759140
10NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.75661166
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.71245987
12SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.70111422
13NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.55007686
14Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.48693678
15MYB_21317192_ChIP-Seq_ERMYB_Mouse2.36803179
16MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.31766744
17VDR_21846776_ChIP-Seq_THP-1_Human2.27392014
18STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.25391079
19STAT4_19710469_ChIP-ChIP_TH1__Mouse2.19792785
20RUNX_20019798_ChIP-Seq_JUKART_Human2.04481503
21* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.02899064
22GATA1_22025678_ChIP-Seq_K562_Human10.2385528
23CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.94762426
24* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.86120033
25RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.76937248
26VDR_24763502_ChIP-Seq_THP-1_Human1.75044093
27SPI1_23547873_ChIP-Seq_NB4_Human1.73130414
28SCL_19346495_ChIP-Seq_HPC-7_Human1.71385197
29MYB_26560356_Chip-Seq_TH2_Human1.70330797
30PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.70132608
31MYC_22102868_ChIP-Seq_BL_Human1.68735245
32VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.58218905
33BRD4_27068464_Chip-Seq_AML-cells_Mouse1.57605560
34SPI1_23127762_ChIP-Seq_K562_Human1.54861147
35ZNF263_19887448_ChIP-Seq_K562_Human1.53838120
36LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.50333845
37MAF_26560356_Chip-Seq_TH1_Human1.50114228
38VDR_24787735_ChIP-Seq_THP-1_Human1.49517909
39IKZF1_21737484_ChIP-ChIP_HCT116_Human1.44509251
40PU_27001747_Chip-Seq_BMDM_Mouse1.40009436
41RUNX1_22412390_ChIP-Seq_EML_Mouse1.31859918
42SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.31084413
43MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.27023493
44CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.26366929
45FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.24083391
46GATA3_26560356_Chip-Seq_TH2_Human1.23937207
47STAT1_20625510_ChIP-Seq_HELA_Human1.23921507
48CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20302841
49UTX_26944678_Chip-Seq_JUKART_Human1.18638100
50BCL6_27268052_Chip-Seq_Bcells_Human1.18495156
51STAT3_1855785_ChIP-Seq_MESCs_Mouse1.17975162
52GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.16868820
53FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.14598906
54LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.12304905
55PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10792087
56PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10085615
57VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.09468917
58CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08711279
59NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.05279259
60STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.03703475
61SMAD_19615063_ChIP-ChIP_OVARY_Human1.03547101
62SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02488348
63ELF1_20517297_ChIP-Seq_JURKAT_Human0.98908453
64GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97869736
65GATA3_27048872_Chip-Seq_THYMUS_Human0.97301379
66EGR1_19374776_ChIP-ChIP_THP-1_Human0.95713489
67PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95565269
68MYB_26560356_Chip-Seq_TH1_Human0.95243346
69KDM2B_26808549_Chip-Seq_SUP-B15_Human0.94083755
70GATA1_19941827_ChIP-Seq_MEL_Mouse0.94004207
71CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93369171
72SPI1_20517297_ChIP-Seq_HL60_Human0.93191628
73TCF7_22412390_ChIP-Seq_EML_Mouse0.92669923
74PU.1_20513432_ChIP-Seq_Bcells_Mouse0.92221617
75SMRT_27268052_Chip-Seq_Bcells_Human0.91385630
76LXR_22292898_ChIP-Seq_THP-1_Human0.89574439
77GATA2_22383799_ChIP-Seq_G1ME_Mouse0.86711620
78GATA1_19941826_ChIP-Seq_K562_Human0.85001145
79TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.84600504
80SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84444908
81SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.80790473
82GATA2_21666600_ChIP-Seq_HMVEC_Human0.78418066
83GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78100792
84MAF_26560356_Chip-Seq_TH2_Human0.77474014
85ESR2_21235772_ChIP-Seq_MCF-7_Human0.75508755
86EZH2_22144423_ChIP-Seq_EOC_Human0.75493794
87TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.74596024
88BCOR_27268052_Chip-Seq_Bcells_Human0.74593272
89KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.72639153
90ELF1_17652178_ChIP-ChIP_JURKAT_Human0.69599914
91SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.68067160
92KDM2B_26808549_Chip-Seq_DND41_Human0.65733603
93EGR1_19032775_ChIP-ChIP_M12_Human0.64548166
94ESET_19884257_ChIP-Seq_ESCs_Mouse0.63559014
95ELK3_25401928_ChIP-Seq_HUVEC_Human0.62580924
96GATA1_22383799_ChIP-Seq_G1ME_Mouse0.61203594
97GATA2_19941826_ChIP-Seq_K562_Human0.61079133
98ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.56468791
99SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.56254410
100GATA1_19941827_ChIP-Seq_MEL86_Mouse0.55864185

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation4.89513438
2MP0004510_myositis3.84640516
3MP0002148_abnormal_hypersensitivity_rea3.35715758
4MP0009785_altered_susceptibility_to3.28453239
5MP0001790_abnormal_immune_system3.27901547
6MP0005387_immune_system_phenotype3.27901547
7MP0001835_abnormal_antigen_presentation3.22599624
8MP0005671_abnormal_response_to3.19086112
9MP0006082_CNS_inflammation3.08986058
10MP0005000_abnormal_immune_tolerance2.86625356
11MP0005397_hematopoietic_system_phenotyp2.72846966
12MP0001545_abnormal_hematopoietic_system2.72846966
13MP0001800_abnormal_humoral_immune2.71179028
14MP0003436_decreased_susceptibility_to2.63991085
15MP0003724_increased_susceptibility_to2.54620043
16MP0002452_abnormal_antigen_presenting2.53050094
17MP0005025_abnormal_response_to2.52433500
18MP0002138_abnormal_hepatobiliary_system2.42183761
19MP0002723_abnormal_immune_serum2.41289215
20MP0002419_abnormal_innate_immunity2.36025660
21MP0002139_abnormal_hepatobiliary_system2.30214314
22MP0005058_abnormal_lysosome_morphology2.28697346
23MP0000685_abnormal_immune_system2.28410351
24MP0003300_gastrointestinal_ulcer2.24542262
25MP0004947_skin_inflammation2.08646876
26MP0002420_abnormal_adaptive_immunity2.00284114
27MP0001819_abnormal_immune_cell2.00179471
28MP0009333_abnormal_splenocyte_physiolog1.93790007
29MP0009840_abnormal_foam_cell1.91916082
30MP0005310_abnormal_salivary_gland1.89503720
31MP0000604_amyloidosis1.88563287
32MP0009764_decreased_sensitivity_to1.84309240
33MP0001845_abnormal_inflammatory_respons1.81337998
34MP0002332_abnormal_exercise_endurance1.81296702
35MP0009278_abnormal_bone_marrow1.80062931
36MP0003075_altered_response_to1.78855681
37MP0001853_heart_inflammation1.77216729
38MP0002405_respiratory_system_inflammati1.73548481
39MP0008469_abnormal_protein_level1.65986892
40MP0010155_abnormal_intestine_physiology1.65854856
41MP0003763_abnormal_thymus_physiology1.64599332
42MP0003172_abnormal_lysosome_physiology1.53082011
43MP0005464_abnormal_platelet_physiology1.51040282
44MP0005451_abnormal_body_composition1.49894910
45MP0000716_abnormal_immune_system1.49640953
46MP0000343_altered_response_to1.48632453
47MP0004808_abnormal_hematopoietic_stem1.47625144
48MP0001533_abnormal_skeleton_physiology1.45458438
49MP0002398_abnormal_bone_marrow1.41029622
50MP0008004_abnormal_stomach_pH1.39106925
51MP0003195_calcinosis1.37049301
52MP0005166_decreased_susceptibility_to1.32267045
53MP0003045_fibrosis1.30886560
54MP0002254_reproductive_system_inflammat1.30732212
55MP0003191_abnormal_cellular_cholesterol1.30190165
56MP0003453_abnormal_keratinocyte_physiol1.23351402
57MP0005167_abnormal_blood-brain_barrier1.19920024
58MP0003806_abnormal_nucleotide_metabolis1.19689972
59MP0002429_abnormal_blood_cell1.14830532
60MP0001873_stomach_inflammation1.12948613
61MP0002998_abnormal_bone_remodeling1.12275597
62MP0003183_abnormal_peptide_metabolism1.11434886
63MP0000689_abnormal_spleen_morphology1.09051696
64MP0009765_abnormal_xenobiotic_induced1.07783403
65MP0001348_abnormal_lacrimal_gland1.05699917
66MP0002722_abnormal_immune_system1.01269755
67MP0003448_altered_tumor_morphology0.98461757
68MP0005647_abnormal_sex_gland0.96578363
69MP0000858_altered_metastatic_potential0.96226322
70MP0009763_increased_sensitivity_to0.93279007
71MP0005165_increased_susceptibility_to0.92476266
72MP0003878_abnormal_ear_physiology0.90717239
73MP0005377_hearing/vestibular/ear_phenot0.90717239
74MP0001501_abnormal_sleep_pattern0.86752208
75MP0005319_abnormal_enzyme/_coenzyme0.86597614
76MP0003690_abnormal_glial_cell0.83428836
77MP0005645_abnormal_hypothalamus_physiol0.81875619
78MP0006054_spinal_hemorrhage0.79467493
79MP0004019_abnormal_vitamin_homeostasis0.78902312
80MP0001663_abnormal_digestive_system0.76546753
81MP0003656_abnormal_erythrocyte_physiolo0.73623919
82MP0003646_muscle_fatigue0.66125410
83MP0008874_decreased_physiological_sensi0.65372714
84MP0001764_abnormal_homeostasis0.62002621
85MP0003091_abnormal_cell_migration0.61512300
86MP0000465_gastrointestinal_hemorrhage0.61403107
87MP0005164_abnormal_response_to0.59871635
88MP0002693_abnormal_pancreas_physiology0.57161263
89MP0003795_abnormal_bone_structure0.56495045
90MP0005379_endocrine/exocrine_gland_phen0.52201775
91MP0002136_abnormal_kidney_physiology0.52057081
92MP0010307_abnormal_tumor_latency0.51946713
93MP0005257_abnormal_intraocular_pressure0.51468044
94MP0000920_abnormal_myelination0.51353483
95MP0005266_abnormal_metabolism0.50972953
96MP0000249_abnormal_blood_vessel0.49711243
97MP0002006_tumorigenesis0.48799391
98MP0000609_abnormal_liver_physiology0.48129916
99MP0009643_abnormal_urine_homeostasis0.47283961
100MP0000703_abnormal_thymus_morphology0.45848808

Predicted human phenotypes

RankGene SetZ-score
1Generalized aminoaciduria (HP:0002909)6.67417731
2Abnormality of glycolipid metabolism (HP:0010969)5.56946555
3Abnormality of liposaccharide metabolism (HP:0010968)5.56946555
4Abnormality of glycosphingolipid metabolism (HP:0004343)5.56946555
5Recurrent bacterial skin infections (HP:0005406)4.39091289
6Abnormality of macrophages (HP:0004311)4.26462268
7Mediastinal lymphadenopathy (HP:0100721)4.12576117
8Gastrointestinal stroma tumor (HP:0100723)4.10886439
9Autoimmune thrombocytopenia (HP:0001973)4.04754907
10Recurrent abscess formation (HP:0002722)3.95971715
11Eczematoid dermatitis (HP:0000976)3.89272004
12Dysostosis multiplex (HP:0000943)3.71272498
13Vacuolated lymphocytes (HP:0001922)3.70156631
14Increased cerebral lipofuscin (HP:0011813)3.63216445
15Optic neuritis (HP:0100653)3.53164990
16Retrobulbar optic neuritis (HP:0100654)3.53164990
17Disinhibition (HP:0000734)3.43904045
18Parakeratosis (HP:0001036)3.40157163
19Vasculitis (HP:0002633)3.38453295
20Recurrent sinusitis (HP:0011108)3.37008827
21Severe visual impairment (HP:0001141)3.36108878
22Proximal tubulopathy (HP:0000114)3.35937846
23Recurrent viral infections (HP:0004429)3.26504749
24Systemic lupus erythematosus (HP:0002725)3.26182132
25Stomatitis (HP:0010280)3.23322404
26Orchitis (HP:0100796)3.16968748
27Loss of speech (HP:0002371)3.16086681
28IgA deficiency (HP:0002720)3.15274717
29Meningitis (HP:0001287)3.10963940
30Recurrent gram-negative bacterial infections (HP:0005420)3.05997333
31Increased IgM level (HP:0003496)3.05272723
32Colitis (HP:0002583)2.98397796
33Increased serum ferritin (HP:0003281)2.93683682
34Agnosia (HP:0010524)2.88706362
35Nausea (HP:0002018)2.88272236
36Increased neuronal autofluorescent lipopigment (HP:0002074)2.87676823
37Recurrent bronchitis (HP:0002837)2.83699157
38Pulmonary infiltrates (HP:0002113)2.79173612
39Myositis (HP:0100614)2.79018200
40Pendular nystagmus (HP:0012043)2.77117669
41Restrictive lung disease (HP:0002091)2.76379537
42IgM deficiency (HP:0002850)2.75888394
43Abnormality of B cell number (HP:0010975)2.72990684
44Agammaglobulinemia (HP:0004432)2.68506010
45Recurrent pneumonia (HP:0006532)2.61311444
46Abnormality of polysaccharide metabolism (HP:0011012)2.60553048
47Abnormality of glycosaminoglycan metabolism (HP:0004371)2.60553048
48Abnormality of mucopolysaccharide metabolism (HP:0011020)2.60553048
49Urinary glycosaminoglycan excretion (HP:0003541)2.60385660
50Mucopolysacchariduria (HP:0008155)2.60385660
51Gangrene (HP:0100758)2.58128653
52Lymphopenia (HP:0001888)2.56492160
53Chronic obstructive pulmonary disease (HP:0006510)2.55099873
54Obstructive lung disease (HP:0006536)2.55099873
55Recurrent fungal infections (HP:0002841)2.51761520
56Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.46618202
57Recurrent skin infections (HP:0001581)2.44634492
58Autoimmune hemolytic anemia (HP:0001890)2.44082094
59Metaphyseal irregularity (HP:0003025)2.40470751
60Abnormality of cells of the lymphoid lineage (HP:0012140)2.40005999
61Abnormality of iron homeostasis (HP:0011031)2.38874526
62B lymphocytopenia (HP:0010976)2.38757712
63Abnormality of T cell number (HP:0011839)2.35182954
64Basal ganglia calcification (HP:0002135)2.34876715
65Emphysema (HP:0002097)2.34701201
66Keratoconjunctivitis sicca (HP:0001097)2.33871525
67Mutism (HP:0002300)2.33693398
68Purpura (HP:0000979)2.28785515
69T lymphocytopenia (HP:0005403)2.26612804
70Inflammation of the large intestine (HP:0002037)2.23595938
71IgG deficiency (HP:0004315)2.22921227
72Abnormal delayed hypersensitivity skin test (HP:0002963)2.19626407
73Hemoptysis (HP:0002105)2.18722684
74Cellulitis (HP:0100658)2.17404807
75Polyneuropathy (HP:0001271)2.17272978
76Nuclear cataract (HP:0100018)2.16845907
77Hematochezia (HP:0002573)2.16800315
78Hypergammaglobulinemia (HP:0010702)2.16388461
79Recurrent lower respiratory tract infections (HP:0002783)2.16371970
80Thoracic kyphosis (HP:0002942)2.13604567
81Encephalitis (HP:0002383)2.12871659
82J-shaped sella turcica (HP:0002680)2.12264453
83Keratoconjunctivitis (HP:0001096)2.11817186
84Chronic diarrhea (HP:0002028)2.09962127
85Urticaria (HP:0001025)2.09191218
86Neurofibrillary tangles (HP:0002185)2.08994037
87Gastrointestinal infarctions (HP:0005244)2.07487643
88Acute lymphatic leukemia (HP:0006721)2.06801917
89Increased IgE level (HP:0003212)2.06731538
90Abnormality of the prostate (HP:0008775)2.06443635
91Glomerulonephritis (HP:0000099)2.05512270
92Gastrointestinal inflammation (HP:0004386)2.05129555
93Malnutrition (HP:0004395)2.01033705
94Arthralgia (HP:0002829)2.00512824
95Abnormality of T cell physiology (HP:0011840)1.99208694
96Hepatosplenomegaly (HP:0001433)1.98828301
97Abnormality of T cells (HP:0002843)1.98366613
98Hypophosphatemia (HP:0002148)1.97408661
99Abnormality of the pleura (HP:0002103)1.93979483
100Vertigo (HP:0002321)1.93699725

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME24.00631234
2MAP4K13.93798032
3RIPK43.72357704
4IRAK33.40762073
5MAP3K143.02099131
6GRK72.95707094
7BLK2.92180225
8TXK2.85688767
9TBK12.50554792
10IKBKB2.37377418
11IKBKE2.33571780
12IRAK42.30856856
13MATK2.30409420
14DDR22.27959467
15TAOK22.26463179
16BMPR22.26436208
17PRPF4B2.16304572
18CDK192.09765156
19JAK32.09605748
20MOS2.03613862
21TYK21.96309802
22SYK1.92898827
23ADRBK21.86417176
24CSK1.80979385
25PIM21.78019493
26FGR1.64190854
27LYN1.48044116
28BTK1.46453911
29CSF1R1.39876505
30JAK11.39831299
31TGFBR21.30760961
32CHUK1.29631152
33ACVR1B1.26809405
34FRK1.20187847
35CDC42BPA1.15748358
36KIT1.09927352
37MAP3K111.06974963
38RIPK11.05448768
39JAK21.02822540
40TAOK31.01110383
41NEK91.01062343
42MAP3K131.00969183
43TAOK11.00534053
44STK100.95334828
45LCK0.94368337
46PIM10.90070782
47MAP3K30.89391107
48ZAP700.89367653
49MAPK40.84921059
50IRAK20.79991068
51HCK0.79095314
52MAP3K50.75719246
53HIPK20.75324283
54IRAK10.68893520
55MARK30.67871033
56TNK20.67027365
57TLK10.66009230
58PKN10.64319996
59DAPK30.59437994
60ARAF0.58301730
61PDK10.56799210
62SIK30.56481231
63MAP2K60.56188419
64INSR0.55821140
65MAPK70.55183471
66TYRO30.53991568
67ERN10.51562071
68AURKA0.51336195
69RPS6KL10.50976043
70RPS6KC10.50976043
71PRKCD0.48683272
72MAP2K30.47802200
73CDK40.47066078
74SIK20.46028083
75MAP3K10.44422507
76CDK60.44218011
77STK240.42183101
78RPS6KA60.41911514
79PDGFRA0.40740190
80ABL10.40497506
81ABL20.39650772
82EGFR0.37540050
83PDPK10.37530685
84TEC0.36089128
85FGFR30.33052152
86PRKCQ0.32855465
87FES0.32221601
88CCNB10.31845279
89DAPK20.31367203
90LATS20.28521043
91PRKCH0.26521623
92FYN0.25292283
93MAPK110.24626521
94LRRK20.23405772
95GRK50.22703049
96CDK120.21187355
97BCKDK0.20992905
98ITK0.20687580
99ALK0.19397522
100RPS6KA20.16883538

Predicted pathways (KEGG)

RankGene SetZ-score
1Intestinal immune network for IgA production_Homo sapiens_hsa046723.88190201
2Allograft rejection_Homo sapiens_hsa053303.82484464
3Asthma_Homo sapiens_hsa053103.68246378
4Graft-versus-host disease_Homo sapiens_hsa053323.28061718
5Autoimmune thyroid disease_Homo sapiens_hsa053203.23047286
6Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.75512248
7Rheumatoid arthritis_Homo sapiens_hsa053232.75337269
8Leishmaniasis_Homo sapiens_hsa051402.70532402
9Type I diabetes mellitus_Homo sapiens_hsa049402.70321518
10Staphylococcus aureus infection_Homo sapiens_hsa051502.53343921
11Toll-like receptor signaling pathway_Homo sapiens_hsa046202.48083032
12RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.43648490
13NF-kappa B signaling pathway_Homo sapiens_hsa040642.33679017
14Other glycan degradation_Homo sapiens_hsa005112.18819356
15Osteoclast differentiation_Homo sapiens_hsa043802.17311694
16Primary immunodeficiency_Homo sapiens_hsa053402.05058477
17Tuberculosis_Homo sapiens_hsa051521.99142313
18African trypanosomiasis_Homo sapiens_hsa051431.97489905
19Renin-angiotensin system_Homo sapiens_hsa046141.87765109
20Antigen processing and presentation_Homo sapiens_hsa046121.87340629
21Lysosome_Homo sapiens_hsa041421.80031313
22B cell receptor signaling pathway_Homo sapiens_hsa046621.79894503
23Influenza A_Homo sapiens_hsa051641.76404230
24Malaria_Homo sapiens_hsa051441.71770665
25Viral myocarditis_Homo sapiens_hsa054161.69004183
26Pertussis_Homo sapiens_hsa051331.63475211
27NOD-like receptor signaling pathway_Homo sapiens_hsa046211.60812586
28TNF signaling pathway_Homo sapiens_hsa046681.60464185
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.59105442
30Toxoplasmosis_Homo sapiens_hsa051451.56360684
31Hematopoietic cell lineage_Homo sapiens_hsa046401.50195610
32Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.47350575
33Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.42679652
34Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.42287931
35Herpes simplex infection_Homo sapiens_hsa051681.40552473
36Glycosaminoglycan degradation_Homo sapiens_hsa005311.36641511
37Measles_Homo sapiens_hsa051621.35659392
38Legionellosis_Homo sapiens_hsa051341.34827276
39Jak-STAT signaling pathway_Homo sapiens_hsa046301.23774757
40Salmonella infection_Homo sapiens_hsa051321.09997582
41Systemic lupus erythematosus_Homo sapiens_hsa053221.09548236
42Phagosome_Homo sapiens_hsa041451.09077062
43Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.07985879
44Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.96172337
45Chemokine signaling pathway_Homo sapiens_hsa040620.91566912
46Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.85366632
47Adipocytokine signaling pathway_Homo sapiens_hsa049200.84091171
48Hepatitis B_Homo sapiens_hsa051610.82970325
49Hepatitis C_Homo sapiens_hsa051600.82462070
50T cell receptor signaling pathway_Homo sapiens_hsa046600.74515222
51Epstein-Barr virus infection_Homo sapiens_hsa051690.73528647
52Apoptosis_Homo sapiens_hsa042100.71736939
53Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.64012889
54Sulfur metabolism_Homo sapiens_hsa009200.60226232
55Sphingolipid metabolism_Homo sapiens_hsa006000.53443913
56Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.52872204
57Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.52640517
58Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.52217585
59Shigellosis_Homo sapiens_hsa051310.51823521
60Neurotrophin signaling pathway_Homo sapiens_hsa047220.50041767
61Prion diseases_Homo sapiens_hsa050200.50004850
62HTLV-I infection_Homo sapiens_hsa051660.48837457
63Type II diabetes mellitus_Homo sapiens_hsa049300.44839523
64Prolactin signaling pathway_Homo sapiens_hsa049170.42895886
65Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.42378835
66Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.39770640
67Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.39219728
68AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.37979053
69Amoebiasis_Homo sapiens_hsa051460.37441295
70Acute myeloid leukemia_Homo sapiens_hsa052210.35962918
71Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.35378840
72Transcriptional misregulation in cancer_Homo sapiens_hsa052020.35350335
73Viral carcinogenesis_Homo sapiens_hsa052030.30836137
74Bladder cancer_Homo sapiens_hsa052190.29804580
75Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.25590441
76Pentose and glucuronate interconversions_Homo sapiens_hsa000400.25129684
77Collecting duct acid secretion_Homo sapiens_hsa049660.22997572
78SNARE interactions in vesicular transport_Homo sapiens_hsa041300.21729169
79Sphingolipid signaling pathway_Homo sapiens_hsa040710.18761676
80Primary bile acid biosynthesis_Homo sapiens_hsa001200.18712308
81VEGF signaling pathway_Homo sapiens_hsa043700.18419864
82Platelet activation_Homo sapiens_hsa046110.17086816
83PPAR signaling pathway_Homo sapiens_hsa033200.16604764
84Galactose metabolism_Homo sapiens_hsa000520.15604631
85Complement and coagulation cascades_Homo sapiens_hsa046100.13605759
86Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.13498554
87FoxO signaling pathway_Homo sapiens_hsa040680.13468675
88Insulin resistance_Homo sapiens_hsa049310.13415438
89Leukocyte transendothelial migration_Homo sapiens_hsa046700.13319179
90Starch and sucrose metabolism_Homo sapiens_hsa005000.11851144
91HIF-1 signaling pathway_Homo sapiens_hsa040660.11800860
92Drug metabolism - other enzymes_Homo sapiens_hsa009830.11369456
93MAPK signaling pathway_Homo sapiens_hsa040100.09583171
94Tryptophan metabolism_Homo sapiens_hsa003800.08267607
95Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.08259556
96Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.06707503
97Fructose and mannose metabolism_Homo sapiens_hsa000510.03621021
98Phototransduction_Homo sapiens_hsa047440.03010413
99Carbohydrate digestion and absorption_Homo sapiens_hsa049730.02761811
100alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.02412184

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