CLMN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)7.32724319
2cilium or flagellum-dependent cell motility (GO:0001539)7.09161051
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.26455809
4L-phenylalanine catabolic process (GO:0006559)6.26455809
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.75527333
6L-phenylalanine metabolic process (GO:0006558)5.75527333
7cilium movement (GO:0003341)5.73670281
8motile cilium assembly (GO:0044458)5.51943436
9aromatic amino acid family catabolic process (GO:0009074)5.17306816
10epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.14862341
11epithelial cilium movement (GO:0003351)4.75879682
12central nervous system myelination (GO:0022010)4.68067032
13axon ensheathment in central nervous system (GO:0032291)4.68067032
14bile acid biosynthetic process (GO:0006699)4.31408902
15ethanol metabolic process (GO:0006067)4.28273286
16indole-containing compound catabolic process (GO:0042436)4.21533075
17indolalkylamine catabolic process (GO:0046218)4.21533075
18tryptophan catabolic process (GO:0006569)4.21533075
19alpha-linolenic acid metabolic process (GO:0036109)4.13888920
20triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.09291655
21sulfur amino acid catabolic process (GO:0000098)4.06043574
22cysteine metabolic process (GO:0006534)4.02437900
23kynurenine metabolic process (GO:0070189)3.99346788
24glyoxylate metabolic process (GO:0046487)3.95403143
25tryptophan metabolic process (GO:0006568)3.91109101
26bile acid metabolic process (GO:0008206)3.82395146
27fatty acid elongation (GO:0030497)3.77120882
28urea metabolic process (GO:0019627)3.76972410
29urea cycle (GO:0000050)3.76972410
30coenzyme catabolic process (GO:0009109)3.72885651
31axoneme assembly (GO:0035082)3.61671097
32aromatic amino acid family metabolic process (GO:0009072)3.61451055
33glutamate metabolic process (GO:0006536)3.57401833
34high-density lipoprotein particle remodeling (GO:0034375)3.54952795
35nitrogen cycle metabolic process (GO:0071941)3.53628573
36primary alcohol catabolic process (GO:0034310)3.50468759
37cellular modified amino acid catabolic process (GO:0042219)3.50428641
38tyrosine metabolic process (GO:0006570)3.50399282
39fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.49251013
40epoxygenase P450 pathway (GO:0019373)3.48880075
41regulation of bile acid biosynthetic process (GO:0070857)3.47213595
42negative regulation of humoral immune response (GO:0002921)3.41996068
43peptidyl-glutamic acid carboxylation (GO:0017187)3.40463304
44protein carboxylation (GO:0018214)3.40463304
45alpha-amino acid catabolic process (GO:1901606)3.39320415
46drug catabolic process (GO:0042737)3.37286786
47complement activation, alternative pathway (GO:0006957)3.36065199
48negative regulation of fibrinolysis (GO:0051918)3.35191852
49short-chain fatty acid metabolic process (GO:0046459)3.34091564
50very long-chain fatty acid metabolic process (GO:0000038)3.30633241
51regulation of fibrinolysis (GO:0051917)3.29211988
52cellular amino acid catabolic process (GO:0009063)3.27896341
53regulation of protein activation cascade (GO:2000257)3.27629957
54cellular ketone body metabolic process (GO:0046950)3.25863645
55sperm capacitation (GO:0048240)3.25832292
56regulation of triglyceride catabolic process (GO:0010896)3.25561744
57serine family amino acid catabolic process (GO:0009071)3.23611263
58homocysteine metabolic process (GO:0050667)3.22217664
59reverse cholesterol transport (GO:0043691)3.15971492
60amino-acid betaine metabolic process (GO:0006577)3.15945817
61acylglycerol homeostasis (GO:0055090)3.15354916
62triglyceride homeostasis (GO:0070328)3.15354916
63heme transport (GO:0015886)3.13924626
64cellular glucuronidation (GO:0052695)3.13117115
65regulation of cholesterol esterification (GO:0010872)3.11285922
66drug transmembrane transport (GO:0006855)3.10572076
67exogenous drug catabolic process (GO:0042738)3.10430895
68protein-lipid complex remodeling (GO:0034368)3.10043238
69macromolecular complex remodeling (GO:0034367)3.10043238
70plasma lipoprotein particle remodeling (GO:0034369)3.10043238
71regulation of complement activation (GO:0030449)3.04697199
72plasma lipoprotein particle clearance (GO:0034381)3.01493685
73bile acid and bile salt transport (GO:0015721)3.00248294
74dicarboxylic acid biosynthetic process (GO:0043650)2.99369666
75amine catabolic process (GO:0009310)2.98517043
76cellular biogenic amine catabolic process (GO:0042402)2.98517043
77vitamin transmembrane transport (GO:0035461)2.96505708
78aspartate family amino acid catabolic process (GO:0009068)2.95853282
79lysine catabolic process (GO:0006554)2.94687341
80lysine metabolic process (GO:0006553)2.94687341
81ethanol oxidation (GO:0006069)2.94068135
82indolalkylamine metabolic process (GO:0006586)2.93621229
83negative regulation of sterol transport (GO:0032372)2.91795123
84negative regulation of cholesterol transport (GO:0032375)2.91795123
85response to methylmercury (GO:0051597)2.91561864
86cholesterol efflux (GO:0033344)2.91309018
87cofactor catabolic process (GO:0051187)2.89719923
88acetyl-CoA metabolic process (GO:0006084)2.87928377
89glucuronate metabolic process (GO:0019585)2.87713990
90uronic acid metabolic process (GO:0006063)2.87713990
91regulation of cholesterol homeostasis (GO:2000188)2.87099981
92negative regulation of lipase activity (GO:0060192)2.84363870
93ensheathment of neurons (GO:0007272)2.83352335
94axon ensheathment (GO:0008366)2.83352335
95ketone body metabolic process (GO:1902224)2.83220591
96myelination (GO:0042552)2.82673236
97drug metabolic process (GO:0017144)2.82339665
98carboxylic acid catabolic process (GO:0046395)2.81837913
99organic acid catabolic process (GO:0016054)2.81837913
100flavonoid metabolic process (GO:0009812)2.81271813
101benzene-containing compound metabolic process (GO:0042537)2.80559699
102diterpenoid biosynthetic process (GO:0016102)2.79496223
103gamma-aminobutyric acid transport (GO:0015812)2.79256001
104regulation of cilium movement (GO:0003352)2.77578655
105cholesterol homeostasis (GO:0042632)2.76785245
106maintenance of gastrointestinal epithelium (GO:0030277)2.76608179
107low-density lipoprotein particle remodeling (GO:0034374)2.76263823
108dicarboxylic acid catabolic process (GO:0043649)2.72046437
109sterol homeostasis (GO:0055092)2.71821482
110fatty-acyl-CoA biosynthetic process (GO:0046949)2.69271745
111negative regulation of protein activation cascade (GO:2000258)2.68874935
112phospholipid efflux (GO:0033700)2.67218704
113negative regulation of B cell mediated immunity (GO:0002713)2.66367313
114negative regulation of immunoglobulin mediated immune response (GO:0002890)2.66367313
115negative regulation of complement activation (GO:0045916)2.65957537
116iron coordination entity transport (GO:1901678)2.65047128
117serine family amino acid metabolic process (GO:0009069)2.64582547
118omega-hydroxylase P450 pathway (GO:0097267)2.64307265
119very-low-density lipoprotein particle assembly (GO:0034379)2.63673272
120arginine metabolic process (GO:0006525)2.62346518
121primary alcohol metabolic process (GO:0034308)2.61641294
122long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.59831146
123phosphatidylethanolamine biosynthetic process (GO:0006646)2.58666476
124quaternary ammonium group transport (GO:0015697)2.58108869
125macroautophagy (GO:0016236)2.53003468
126carnitine transport (GO:0015879)2.49527743
127amino-acid betaine transport (GO:0015838)2.49527743
128blood coagulation, intrinsic pathway (GO:0007597)2.49005734
129hydrogen peroxide biosynthetic process (GO:0050665)2.47769506
130carnitine transmembrane transport (GO:1902603)2.46940265
131pyrimidine-containing compound transmembrane transport (GO:0072531)2.44139105
132fusion of sperm to egg plasma membrane (GO:0007342)2.43881925
133excretion (GO:0007588)2.43591574
134regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.42472563
135cellular response to ethanol (GO:0071361)2.40892196
136regulation of interleukin-13 production (GO:0032656)2.40680407
137phosphatidylethanolamine metabolic process (GO:0046337)2.40227118
138sperm motility (GO:0030317)2.40145429
139regulation of humoral immune response (GO:0002920)2.36234854
140fibrinolysis (GO:0042730)2.36079404
141antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.35587704
142phospholipid homeostasis (GO:0055091)2.34853549
143carnitine metabolic process (GO:0009437)2.34163668
144ventricular system development (GO:0021591)2.33478972
145one-carbon compound transport (GO:0019755)2.31876284
146positive regulation of blood coagulation (GO:0030194)2.29590012
147positive regulation of hemostasis (GO:1900048)2.29590012
148regulation of germinal center formation (GO:0002634)2.28058485
149negative regulation of inclusion body assembly (GO:0090084)2.26876132
150protein activation cascade (GO:0072376)2.26096662
151phosphatidylcholine biosynthetic process (GO:0006656)2.24002306
152positive regulation of coagulation (GO:0050820)2.23876772
153positive regulation of lipid catabolic process (GO:0050996)2.23764312
154embryonic retina morphogenesis in camera-type eye (GO:0060059)2.21758592
155microtubule bundle formation (GO:0001578)2.21297646
156retinol metabolic process (GO:0042572)2.20987559
157negative regulation of blood coagulation (GO:0030195)2.20356728
158negative regulation of hemostasis (GO:1900047)2.20356728
159sodium ion homeostasis (GO:0055078)2.16652991
160reactive oxygen species biosynthetic process (GO:1903409)2.15203393
161left/right pattern formation (GO:0060972)2.12376013
162left/right axis specification (GO:0070986)2.11783666
163multicellular organismal water homeostasis (GO:0050891)2.10728940
164iron ion import (GO:0097286)2.10574312
165glomerular epithelial cell development (GO:0072310)2.09749976
166negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.09216311
167phenylpropanoid metabolic process (GO:0009698)2.08376376

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.11541545
2* RXR_22158963_ChIP-Seq_LIVER_Mouse3.79261035
3* LXR_22158963_ChIP-Seq_LIVER_Mouse3.29885560
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.99691274
5EGR1_23403033_ChIP-Seq_LIVER_Mouse2.85640130
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.61176103
7NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.32234105
8GBX2_23144817_ChIP-Seq_PC3_Human2.23882366
9FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.06736599
10IRF8_22096565_ChIP-ChIP_GC-B_Human2.05504018
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.88930814
12EZH2_22144423_ChIP-Seq_EOC_Human1.83644837
13ESR1_21235772_ChIP-Seq_MCF-7_Human1.83301370
14SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.82479653
15SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.73801276
16DROSHA_22980978_ChIP-Seq_HELA_Human1.63936954
17MTF2_20144788_ChIP-Seq_MESCs_Mouse1.63881321
18EZH2_18974828_ChIP-Seq_MESCs_Mouse1.61979512
19RNF2_18974828_ChIP-Seq_MESCs_Mouse1.61979512
20SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.60523747
21SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.53175616
22TAF15_26573619_Chip-Seq_HEK293_Human1.52194427
23SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.46850351
24PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.46445208
25JARID2_20064375_ChIP-Seq_MESCs_Mouse1.45935110
26EZH2_27294783_Chip-Seq_ESCs_Mouse1.45319564
27SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.44620242
28CTNNB1_20460455_ChIP-Seq_HCT116_Human1.44203224
29SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.43603709
30EED_16625203_ChIP-ChIP_MESCs_Mouse1.43261661
31JARID2_20075857_ChIP-Seq_MESCs_Mouse1.41946755
32Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.41246454
33SUZ12_27294783_Chip-Seq_ESCs_Mouse1.41162429
34CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.40924558
35FOXA2_19822575_ChIP-Seq_HepG2_Human1.36190564
36* FOXO3_23340844_ChIP-Seq_DLD1_Human1.36167177
37PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.35795347
38GATA2_21666600_ChIP-Seq_HMVEC_Human1.32896411
39STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.27352381
40IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.26220488
41PIAS1_25552417_ChIP-Seq_VCAP_Human1.25876636
42FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.25408652
43EZH2_27304074_Chip-Seq_ESCs_Mouse1.24328990
44RUNX1_27514584_Chip-Seq_MCF-7_Human1.22053587
45PPAR_26484153_Chip-Seq_NCI-H1993_Human1.21331337
46ESR2_21235772_ChIP-Seq_MCF-7_Human1.20056843
47GATA4_25053715_ChIP-Seq_YYC3_Human1.20047802
48RNF2_27304074_Chip-Seq_ESCs_Mouse1.19943619
49* SOX2_20726797_ChIP-Seq_SW620_Human1.19181383
50SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18770814
51REST_21632747_ChIP-Seq_MESCs_Mouse1.18553854
52HTT_18923047_ChIP-ChIP_STHdh_Human1.16458048
53ERG_21242973_ChIP-ChIP_JURKAT_Human1.15795151
54TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.15482661
55GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15435860
56* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.15392746
57CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.13887570
58ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.12342741
59* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.11896539
60* CDX2_19796622_ChIP-Seq_MESCs_Mouse1.09948920
61TP63_23658742_ChIP-Seq_EP156T_Human1.09902440
62FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.09116203
63GATA1_19941826_ChIP-Seq_K562_Human1.08513347
64* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.07373526
65MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.06397588
66AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.05767386
67CTBP1_25329375_ChIP-Seq_LNCAP_Human1.04300779
68AR_21572438_ChIP-Seq_LNCaP_Human1.03476019
69GATA2_19941826_ChIP-Seq_K562_Human1.03160314
70IRF8_27001747_Chip-Seq_BMDM_Mouse1.02802688
71TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02371939
72RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.02284310
73SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.02167166
74* VDR_24787735_ChIP-Seq_THP-1_Human1.01343437
75VDR_22108803_ChIP-Seq_LS180_Human1.01243595
76RARB_27405468_Chip-Seq_BRAIN_Mouse1.00710188
77GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99976979
78PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99399576
79* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.99277761
80FOXA1_25552417_ChIP-Seq_VCAP_Human0.99276309
81KLF5_25053715_ChIP-Seq_YYC3_Human0.99201401
82SMAD4_21799915_ChIP-Seq_A2780_Human0.99174807
83SPI1_23127762_ChIP-Seq_K562_Human0.99126768
84PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.99073094
85SMAD_19615063_ChIP-ChIP_OVARY_Human0.98339978
86STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.98301982
87SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.98036807
88NRF2_20460467_ChIP-Seq_MEFs_Mouse0.97523495
89NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.97523495
90* AHR_22903824_ChIP-Seq_MCF-7_Human0.97132034
91* VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.97036270
92CTBP2_25329375_ChIP-Seq_LNCAP_Human0.96546092
93* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.96365670
94* GATA1_19941827_ChIP-Seq_MEL_Mouse0.96333004
95BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.96200615
96SMAD3_21741376_ChIP-Seq_EPCs_Human0.96033721
97TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.95034283
98ZFP57_27257070_Chip-Seq_ESCs_Mouse0.94282314
99* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.92946441
100TP53_16413492_ChIP-PET_HCT116_Human0.92880168
101* ARNT_22903824_ChIP-Seq_MCF-7_Human0.92839066
102SCL_19346495_ChIP-Seq_HPC-7_Human0.92347630
103RUNX_20019798_ChIP-Seq_JUKART_Human0.92001058
104* TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.91301878
105REST_18959480_ChIP-ChIP_MESCs_Mouse0.91297149
106* STAT3_23295773_ChIP-Seq_U87_Human0.90870595
107THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.90801479
108NR3C1_21868756_ChIP-Seq_MCF10A_Human0.90352591
109TCF4_18268006_ChIP-ChIP_LS174T_Human0.90046831
110* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.90036305
111SMRT_27268052_Chip-Seq_Bcells_Human0.89337463
112CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.89098684
113STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.88994456
114ESR1_20079471_ChIP-ChIP_T-47D_Human0.88437845
115ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.88057297
116* SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.87813961
117BCAT_22108803_ChIP-Seq_LS180_Human0.87801095
118P63_26484246_Chip-Seq_KERATINOCYTES_Human0.87317652
119OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.86986530
120CDX2_22108803_ChIP-Seq_LS180_Human0.86198113
121TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86176288
122* SMAD4_21741376_ChIP-Seq_HESCs_Human0.86107174
123RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.84543564
124* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.83791883
125PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.83651302
126EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.83076444
127SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.82854861
128CBX2_27304074_Chip-Seq_ESCs_Mouse0.82341306
129GATA6_25053715_ChIP-Seq_YYC3_Human0.82319827
130ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.82148314
131CEBPB_22108803_ChIP-Seq_LS180_Human0.81611737
132RXR_22108803_ChIP-Seq_LS180_Human0.81369450
133RING1B_27294783_Chip-Seq_ESCs_Mouse0.81068220
134TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.80816330
135CDX2_20551321_ChIP-Seq_CACO-2_Human0.80490853
136P300_19829295_ChIP-Seq_ESCs_Human0.79690205
137SMAD4_21741376_ChIP-Seq_EPCs_Human0.79450278
138* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.79048933
139SMAD3_21741376_ChIP-Seq_HESCs_Human0.78857854
140* SOX2_21211035_ChIP-Seq_LN229_Gbm0.78827228
141GATA3_24758297_ChIP-Seq_MCF-7_Human0.78749691
142TP63_22573176_ChIP-Seq_HFKS_Human0.78436321
143* HNF4A_19822575_ChIP-Seq_HepG2_Human0.77106383
144TCF4_23295773_ChIP-Seq_U87_Human0.76958625
145IKZF1_21737484_ChIP-ChIP_HCT116_Human0.76887361
146UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.76030002
147OCT1_27270436_Chip-Seq_PROSTATE_Human0.75834070
148MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.75539712
149* AR_19668381_ChIP-Seq_PC3_Human0.74089654
150BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.73806711
151PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.73756522
152CJUN_26792858_Chip-Seq_BT549_Human0.73276966
153AR_25329375_ChIP-Seq_VCAP_Human0.73106657
154ER_23166858_ChIP-Seq_MCF-7_Human0.72649748
155STAT1_20625510_ChIP-Seq_HELA_Human0.72455247
156EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.72394247
157* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.72342061

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.16947873
2MP0005360_urolithiasis5.68370264
3MP0005085_abnormal_gallbladder_physiolo4.64694998
4MP0005365_abnormal_bile_salt4.47819165
5MP0008875_abnormal_xenobiotic_pharmacok4.14267740
6MP0003252_abnormal_bile_duct3.07605406
7MP0003806_abnormal_nucleotide_metabolis2.68420184
8MP0005083_abnormal_biliary_tract2.48046317
9MP0005332_abnormal_amino_acid2.48041133
10MP0010329_abnormal_lipoprotein_level2.47605608
11MP0002132_abnormal_respiratory_system2.28357604
12MP0000920_abnormal_myelination2.27805470
13MP0003195_calcinosis2.24896366
14MP0003690_abnormal_glial_cell2.24633367
15MP0001666_abnormal_nutrient_absorption2.07161527
16MP0003880_abnormal_central_pattern2.03660732
17MP0009840_abnormal_foam_cell1.98313148
18MP0004859_abnormal_synaptic_plasticity1.97308607
19MP0004270_analgesia1.94496280
20MP0003329_amyloid_beta_deposits1.91706702
21MP0005464_abnormal_platelet_physiology1.83687532
22MP0002118_abnormal_lipid_homeostasis1.81579956
23MP0004043_abnormal_pH_regulation1.79745115
24MP0004019_abnormal_vitamin_homeostasis1.78004894
25MP0004885_abnormal_endolymph1.76756636
26MP0002653_abnormal_ependyma_morphology1.74374213
27MP0003879_abnormal_hair_cell1.74256647
28MP0002138_abnormal_hepatobiliary_system1.73685049
29MP0005410_abnormal_fertilization1.69698608
30MP0003183_abnormal_peptide_metabolism1.67892132
31MP0003724_increased_susceptibility_to1.61394178
32MP0005666_abnormal_adipose_tissue1.61276268
33MP0001486_abnormal_startle_reflex1.60414341
34MP0003045_fibrosis1.56066732
35MP0002168_other_aberrant_phenotype1.55233809
36MP0002822_catalepsy1.55055669
37MP0009046_muscle_twitch1.50560598
38MP0005310_abnormal_salivary_gland1.48442671
39MP0003868_abnormal_feces_composition1.46235210
40MP0003303_peritoneal_inflammation1.45998430
41MP0005451_abnormal_body_composition1.43711257
42MP0008004_abnormal_stomach_pH1.43602191
43MP0002064_seizures1.42382425
44MP0010234_abnormal_vibrissa_follicle1.37934109
45MP0002272_abnormal_nervous_system1.37540128
46MP0010155_abnormal_intestine_physiology1.37441518
47MP0003866_abnormal_defecation1.35306377
48MP0009745_abnormal_behavioral_response1.34648508
49MP0003635_abnormal_synaptic_transmissio1.34280857
50MP0000604_amyloidosis1.31856845
51MP0005584_abnormal_enzyme/coenzyme_acti1.29092684
52MP0001756_abnormal_urination1.28687039
53MP0005377_hearing/vestibular/ear_phenot1.25433511
54MP0003878_abnormal_ear_physiology1.25433511
55MP0000609_abnormal_liver_physiology1.22519964
56MP0005409_darkened_coat_color1.20930066
57MP0002254_reproductive_system_inflammat1.19701158
58MP0003191_abnormal_cellular_cholesterol1.18741092
59MP0003011_delayed_dark_adaptation1.14971416
60MP0004130_abnormal_muscle_cell1.14457602
61MP0000566_synostosis1.10797317
62MP0005375_adipose_tissue_phenotype1.10706627
63MP0001835_abnormal_antigen_presentation1.10330264
64MP0005167_abnormal_blood-brain_barrier1.10256936
65MP0004883_abnormal_blood_vessel1.08907544
66MP0004142_abnormal_muscle_tone1.08148817
67MP0001501_abnormal_sleep_pattern1.07714642
68MP0002136_abnormal_kidney_physiology1.06972634
69MP0002909_abnormal_adrenal_gland1.06295160
70MP0003632_abnormal_nervous_system1.04879526
71MP0005164_abnormal_response_to1.04694499
72MP0001440_abnormal_grooming_behavior1.04372735
73MP0002229_neurodegeneration1.01850839
74MP0005387_immune_system_phenotype1.01728167
75MP0001790_abnormal_immune_system1.01728167
76MP0005166_decreased_susceptibility_to1.00980955
77MP0003300_gastrointestinal_ulcer1.00874758
78MP0002572_abnormal_emotion/affect_behav1.00837504
79MP0005319_abnormal_enzyme/_coenzyme0.98659597
80MP0010386_abnormal_urinary_bladder0.98582984
81MP0002876_abnormal_thyroid_physiology0.97330244
82MP0002063_abnormal_learning/memory/cond0.96358954
83MP0009115_abnormal_fat_cell0.95019568
84MP0003633_abnormal_nervous_system0.94706288
85MP0001984_abnormal_olfaction0.94162334
86MP0001485_abnormal_pinna_reflex0.93746646
87MP0004381_abnormal_hair_follicle0.92554701
88MP0009643_abnormal_urine_homeostasis0.91049544
89MP0009780_abnormal_chondrocyte_physiolo0.90054552
90MP0003634_abnormal_glial_cell0.89962979
91MP0000249_abnormal_blood_vessel0.89346538
92MP0002734_abnormal_mechanical_nocicepti0.89259888
93MP0004742_abnormal_vestibular_system0.89135560
94MP0003631_nervous_system_phenotype0.88485721
95MP0008961_abnormal_basal_metabolism0.85272906
96MP0005025_abnormal_response_to0.85161645
97MP0001664_abnormal_digestion0.84976217
98MP0005647_abnormal_sex_gland0.84930744
99MP0000579_abnormal_nail_morphology0.84800942
100MP0001800_abnormal_humoral_immune0.84184354
101MP0001663_abnormal_digestive_system0.83764173
102MP0001661_extended_life_span0.83257217
103MP0004484_altered_response_of0.82022033
104MP0000230_abnormal_systemic_arterial0.81742456
105MP0000778_abnormal_nervous_system0.80273814
106MP0008872_abnormal_physiological_respon0.80232891
107MP0005551_abnormal_eye_electrophysiolog0.79236849
108MP0004947_skin_inflammation0.78843213
109MP0003453_abnormal_keratinocyte_physiol0.78701203
110MP0009785_altered_susceptibility_to0.78648778
111MP0001845_abnormal_inflammatory_respons0.78044768
112MP0005248_abnormal_Harderian_gland0.77522156
113MP0002078_abnormal_glucose_homeostasis0.77424851
114MP0000465_gastrointestinal_hemorrhage0.77248223
115MP0005535_abnormal_body_temperature0.76482443
116MP0008874_decreased_physiological_sensi0.75957259
117MP0005058_abnormal_lysosome_morphology0.75684028
118MP0003950_abnormal_plasma_membrane0.75419963
119MP0000462_abnormal_digestive_system0.75120482
120MP0002067_abnormal_sensory_capabilities0.73889987
121MP0010678_abnormal_skin_adnexa0.73725520
122MP0004510_myositis0.73559623
123MP0001177_atelectasis0.72447832
124MP0003638_abnormal_response/metabolism_0.72348010
125MP0005395_other_phenotype0.72087743
126MP0005448_abnormal_energy_balance0.71828114
127MP0005423_abnormal_somatic_nervous0.71396751
128MP0002277_abnormal_respiratory_mucosa0.71306999
129MP0009642_abnormal_blood_homeostasis0.71090063
130MP0003172_abnormal_lysosome_physiology0.71014886
131MP0002419_abnormal_innate_immunity0.70886200
132MP0003075_altered_response_to0.69378552
133MP0005646_abnormal_pituitary_gland0.69363725
134MP0001765_abnormal_ion_homeostasis0.69131075
135MP0005636_abnormal_mineral_homeostasis0.68720828
136MP0001764_abnormal_homeostasis0.68645985
137MP0000955_abnormal_spinal_cord0.68298353
138MP0002066_abnormal_motor_capabilities/c0.66876924
139MP0001905_abnormal_dopamine_level0.66596181
140MP0005670_abnormal_white_adipose0.65568939
141MP0001963_abnormal_hearing_physiology0.64995721
142MP0005084_abnormal_gallbladder_morpholo0.63507851
143MP0002971_abnormal_brown_adipose0.63360882
144MP0008569_lethality_at_weaning0.61839874
145MP0001502_abnormal_circadian_rhythm0.60645079
146MP0005408_hypopigmentation0.59865560
147MP0004264_abnormal_extraembryonic_tissu0.59191597
148MP0005386_behavior/neurological_phenoty0.59139327
149MP0004924_abnormal_behavior0.59139327
150MP0001346_abnormal_lacrimal_gland0.58325341
151MP0000639_abnormal_adrenal_gland0.58145275
152MP0002882_abnormal_neuron_morphology0.56541928
153MP0003656_abnormal_erythrocyte_physiolo0.55973361
154MP0002069_abnormal_eating/drinking_beha0.55185408
155MP0000383_abnormal_hair_follicle0.54175837
156MP0009384_cardiac_valve_regurgitation0.54044133
157MP0004858_abnormal_nervous_system0.53535351
158MP0002733_abnormal_thermal_nociception0.51930131

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)7.48536500
2Absent/shortened dynein arms (HP:0200106)7.06851453
3Dynein arm defect of respiratory motile cilia (HP:0012255)7.06851453
4Abnormal ciliary motility (HP:0012262)6.92894971
5Abnormal respiratory epithelium morphology (HP:0012253)6.81835873
6Abnormal respiratory motile cilium morphology (HP:0005938)6.81835873
7Abnormal respiratory motile cilium physiology (HP:0012261)6.76895313
8Rhinitis (HP:0012384)6.06519608
9Intrahepatic cholestasis (HP:0001406)5.82623487
10Abnormality of aromatic amino acid family metabolism (HP:0004338)5.75635968
11Deep venous thrombosis (HP:0002625)5.35542660
12Chronic bronchitis (HP:0004469)4.91017757
13Bronchiectasis (HP:0002110)4.81929440
14Xanthomatosis (HP:0000991)4.59505413
15Hyperactive renin-angiotensin system (HP:0000841)4.58600186
16Nasal polyposis (HP:0100582)4.52100437
17Abnormality of monocarboxylic acid metabolism (HP:0010996)4.49820077
18Hyperlipoproteinemia (HP:0010980)4.40919482
19Prolonged partial thromboplastin time (HP:0003645)4.39458755
20Neurofibrillary tangles (HP:0002185)3.98282323
21Hypobetalipoproteinemia (HP:0003563)3.75594144
22Abnormality of the nasal mucosa (HP:0000433)3.74247186
23Complement deficiency (HP:0004431)3.52723146
24Abnormality of glycine metabolism (HP:0010895)3.46281128
25Abnormality of serine family amino acid metabolism (HP:0010894)3.46281128
26Recurrent sinusitis (HP:0011108)3.46141976
27Hyperglycinemia (HP:0002154)3.38147779
28Abnormality of aspartate family amino acid metabolism (HP:0010899)3.36315776
29Hyperammonemia (HP:0001987)3.34969443
30Ketosis (HP:0001946)3.30719557
31Epidermoid cyst (HP:0200040)3.30052418
32Infertility (HP:0000789)3.27453634
33Hyperglycinuria (HP:0003108)3.27181359
34Bronchitis (HP:0012387)3.26995680
35Abnormality of methionine metabolism (HP:0010901)3.26096413
36Abnormality of glutamine family amino acid metabolism (HP:0010902)3.12204810
37Abnormality of sulfur amino acid metabolism (HP:0004339)3.11802330
38Fat malabsorption (HP:0002630)3.11690120
39Abnormality of chloride homeostasis (HP:0011422)3.11195564
40Joint hemorrhage (HP:0005261)3.05784956
41Hypolipoproteinemia (HP:0010981)3.01813855
42Cerebral inclusion bodies (HP:0100314)2.95776226
43Male infertility (HP:0003251)2.94643645
44Hypoalphalipoproteinemia (HP:0003233)2.92980843
45Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.92704490
46Hyperkalemia (HP:0002153)2.92285508
47Hyperventilation (HP:0002883)2.89411493
48Recurrent otitis media (HP:0000403)2.87635165
49Chronic sinusitis (HP:0011109)2.86854791
50Abnormality of the corticospinal tract (HP:0002492)2.83118104
51Confusion (HP:0001289)2.80736280
52Menorrhagia (HP:0000132)2.79681481
53Abnormality of renin-angiotensin system (HP:0000847)2.79559210
54Gout (HP:0001997)2.79199702
55Conjugated hyperbilirubinemia (HP:0002908)2.79119892
56Hyperaldosteronism (HP:0000859)2.78897041
57Sensory axonal neuropathy (HP:0003390)2.78109476
58Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.73086571
59Degeneration of the lateral corticospinal tracts (HP:0002314)2.73086571
60Intention tremor (HP:0002080)2.70536467
61Prolonged bleeding time (HP:0003010)2.68626395
62Vascular calcification (HP:0004934)2.68339529
63Decreased circulating renin level (HP:0003351)2.64244610
64Hypercholesterolemia (HP:0003124)2.61034180
65Delayed CNS myelination (HP:0002188)2.59423076
66Purpura (HP:0000979)2.58138329
67Myokymia (HP:0002411)2.50453604
68Spastic tetraparesis (HP:0001285)2.48561992
69Tubulointerstitial nephritis (HP:0001970)2.45254841
70Hypochromic microcytic anemia (HP:0004840)2.44787254
71Abnormality of the common coagulation pathway (HP:0010990)2.43509295
72Steatorrhea (HP:0002570)2.41916521
73Renal salt wasting (HP:0000127)2.38418682
74Alkalosis (HP:0001948)2.36899003
75Gingival bleeding (HP:0000225)2.36824387
76Glomerulonephritis (HP:0000099)2.35785356
77Chronic otitis media (HP:0000389)2.35781149
78Increased circulating renin level (HP:0000848)2.35525854
79Amyloidosis (HP:0011034)2.35422085
80Recurrent gram-negative bacterial infections (HP:0005420)2.34285297
81Dysmetria (HP:0001310)2.33581655
82Metabolic alkalosis (HP:0200114)2.32330873
83Cardiovascular calcification (HP:0011915)2.31642786
84Ketoacidosis (HP:0001993)2.30204839
85Hypophosphatemic rickets (HP:0004912)2.29063421
86Chronic hepatic failure (HP:0100626)2.27878795
87Enlarged kidneys (HP:0000105)2.27820129
88Scanning speech (HP:0002168)2.25614334
89Abnormality of complement system (HP:0005339)2.25446680
90Spastic gait (HP:0002064)2.24561978
91Abnormality of purine metabolism (HP:0004352)2.23433108
92Rickets (HP:0002748)2.23308112
93Systemic lupus erythematosus (HP:0002725)2.18898602
94Metabolic acidosis (HP:0001942)2.15660099
95Status epilepticus (HP:0002133)2.15439276
96Recurrent bronchitis (HP:0002837)2.14230501
97Flat acetabular roof (HP:0003180)2.13000314
98Abnormality of the intrinsic pathway (HP:0010989)2.12585415
99Turricephaly (HP:0000262)2.11913897
100Focal motor seizures (HP:0011153)2.09136829
101Cholecystitis (HP:0001082)2.07981681
102Abnormal gallbladder physiology (HP:0012438)2.07981681
103Abnormality of fatty-acid metabolism (HP:0004359)2.07222411
104Hyperbilirubinemia (HP:0002904)2.06959810
105Nephritis (HP:0000123)2.06690583
106Abnormality of serum amino acid levels (HP:0003112)2.03900268
107Onion bulb formation (HP:0003383)2.03611607
108Potter facies (HP:0002009)2.03579913
109Facial shape deformation (HP:0011334)2.03579913
110Supranuclear gaze palsy (HP:0000605)2.03113611
111Abnormality of nucleobase metabolism (HP:0010932)2.03049428
112Hypoglycemic coma (HP:0001325)2.01769150
113Spastic paraparesis (HP:0002313)2.01575402
114Skin nodule (HP:0200036)2.00790593
115Epistaxis (HP:0000421)1.99579633
116Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.99080899
117Aplasia involving bones of the upper limbs (HP:0009823)1.98219769
118Aplasia of the phalanges of the hand (HP:0009802)1.98219769
119Aplasia involving bones of the extremities (HP:0009825)1.98219769
120Hypokalemic alkalosis (HP:0001949)1.97811384
121Irritability (HP:0000737)1.95890563
122Abnormality of renal excretion (HP:0011036)1.94852870
123Hyperuricemia (HP:0002149)1.93382967
124Increased purine levels (HP:0004368)1.93382967
125Malnutrition (HP:0004395)1.93133567
126Abnormality of vitamin metabolism (HP:0100508)1.91069921
127Tubular atrophy (HP:0000092)1.90418534
128Spontaneous abortion (HP:0005268)1.90365801
129Abnormality of potassium homeostasis (HP:0011042)1.90320643
130Hyperinsulinemic hypoglycemia (HP:0000825)1.89524110
131Synostosis involving the elbow (HP:0003938)1.87981434
132Humeroradial synostosis (HP:0003041)1.87981434
133Cystic liver disease (HP:0006706)1.86229732
134Cone-rod dystrophy (HP:0000548)1.84273130
135Infantile muscular hypotonia (HP:0008947)1.84153074
136Coronal craniosynostosis (HP:0004440)1.82225120
137Action tremor (HP:0002345)1.81043423
138Occipital encephalocele (HP:0002085)1.80890224
139Abnormal gallbladder morphology (HP:0012437)1.80491842
140Lethargy (HP:0001254)1.80277841
141Bifid scrotum (HP:0000048)1.73604416
142Morphological abnormality of the pyramidal tract (HP:0002062)1.73125102
143Bell-shaped thorax (HP:0001591)1.71485973
144Abnormality of dicarboxylic acid metabolism (HP:0010995)1.71394365
145Dicarboxylic aciduria (HP:0003215)1.71394365
146Hemorrhage of the eye (HP:0011885)1.70160197
147Hypoglycemic seizures (HP:0002173)1.69356517
148Generalized myoclonic seizures (HP:0002123)1.68518583
149Abnormal urine output (HP:0012590)1.65303896
150Portal hypertension (HP:0001409)1.64762738
151Mitral stenosis (HP:0001718)1.64556447
152Increased mean platelet volume (HP:0011877)1.63878143
153Amelogenesis imperfecta (HP:0000705)1.63394254
154Decreased central vision (HP:0007663)1.62219024
155Hypokalemia (HP:0002900)1.61178594
156True hermaphroditism (HP:0010459)1.61124563
157Abnormality of the renal medulla (HP:0100957)1.60363400
158Adrenal overactivity (HP:0002717)1.59523383
159Ventricular fibrillation (HP:0001663)1.58771681
160Abnormal platelet volume (HP:0011876)1.58065657
161Abnormal drinking behavior (HP:0030082)1.57436442
162Polydipsia (HP:0001959)1.57436442
163Progressive cerebellar ataxia (HP:0002073)1.57218867
164Right ventricular cardiomyopathy (HP:0011663)1.56228906
165Obstructive sleep apnea (HP:0002870)1.55537848
166Hyponatremia (HP:0002902)1.55093374
167Pancreatic cysts (HP:0001737)1.53270200
168Stage 5 chronic kidney disease (HP:0003774)1.51483208
169Abnormality of the hepatic vasculature (HP:0006707)1.48694286
170Recurrent pneumonia (HP:0006532)1.48597501
171Atelectasis (HP:0100750)1.48154133
172Bronchomalacia (HP:0002780)1.46205172
173Petechiae (HP:0000967)1.45459127
174Increased cerebral lipofuscin (HP:0011813)1.42263384

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.34170141
2OXSR13.82855490
3EPHA23.42637299
4RIPK43.10372648
5MST43.00615213
6EPHA42.72497090
7WNK42.51637548
8EPHB12.41584680
9TNIK2.41307659
10FGFR22.33599173
11FRK2.17146643
12WNK12.06631687
13BLK2.01326423
14BCKDK1.93307355
15ICK1.90089326
16SIK11.89263336
17NTRK11.81670842
18PKN11.74138763
19MET1.73891672
20NTRK31.72692807
21INSRR1.71353299
22MAPKAPK31.70101212
23TRIB31.65164869
24ERBB41.63548756
25PRPF4B1.57501081
26MAP3K31.57091938
27PIK3CA1.49744906
28MAP2K41.45136465
29TNK21.44813164
30PAK61.40097156
31TYRO31.37167384
32BCR1.37095879
33SGK4941.36817981
34SGK2231.36817981
35CDK191.34281534
36DAPK21.32402331
37NEK61.30392170
38STK241.25966707
39CAMK2B1.24087888
40ACVR1B1.21403470
41RIPK11.19695235
42CAMK2G1.18778703
43CSK1.18128348
44PAK31.16951237
45MAP3K71.13335510
46PIK3CG1.11403376
47CDK121.08362477
48FGFR41.07783931
49PNCK1.07205937
50STK38L1.06507952
51MST1R1.06363751
52NTRK21.06184943
53GRK51.06091045
54BMPR21.04668450
55CAMK1G1.01235006
56MARK21.01097357
57PINK10.99456360
58EPHA30.98856541
59BTK0.98297476
60MAPK150.97841002
61CSNK1A1L0.96601990
62TRPM70.95542800
63PRKD30.94671678
64ZAP700.94510576
65FGFR30.94391029
66MYLK0.94353399
67CAMK2D0.93641648
68PDPK10.93049425
69CSNK1G20.91663429
70STK380.91226562
71MAP3K120.89929111
72TYK20.88233419
73MAPK70.88084870
74FGR0.87477152
75CSF1R0.86496550
76CDK50.85834741
77JAK10.85791760
78ERN10.85562380
79CDC42BPA0.85493631
80AKT30.85480815
81RET0.82974134
82GRK10.82081679
83CAMK2A0.81541347
84PKN20.80624033
85PBK0.80021033
86TAOK10.80017917
87IRAK10.79793083
88CASK0.78556735
89MARK10.78122078
90CSNK1G30.77057651
91PRKCQ0.76702437
92CSNK1G10.75806259
93MAP3K130.75391937
94MAP3K40.75233366
95MAP3K10.74761878
96ERBB20.74404893
97PRKCG0.73592153
98NLK0.69853285
99MAP3K90.68895885
100PHKG20.68514864
101PHKG10.68514864
102PRKCH0.68315480
103WNK30.66896902
104UHMK10.65964084
105PDK10.65575866
106STK110.63819787
107CAMKK10.63778603
108PDGFRB0.62572868
109PRKCZ0.62346082
110MAP3K20.62337941
111SYK0.62193207
112SGK30.61841114
113EEF2K0.61593814
114MAPKAPK50.59920794
115ADRBK20.58913109
116BMX0.58825171
117ROCK20.58801188
118PRKAA20.58463945
119GRK60.58400540
120CHUK0.58370801
121KSR20.57918743
122MAP3K60.56769253
123PTK20.56404267
124MAP2K60.56343098
125DDR20.55196193
126PRKCE0.53968536
127TAOK30.53266597
128IRAK20.52698626
129PTK2B0.51322395
130PRKD10.51209767
131MATK0.50506927
132CAMK10.50429592
133TESK10.50366724
134HIPK20.50078682
135GSK3A0.49381124
136TBK10.49338269
137FYN0.48696987
138IKBKE0.47477197
139LATS10.47462104
140SGK20.46572351
141MINK10.46195159
142JAK20.45652050
143IKBKB0.45563926
144PRKAA10.45472970
145SGK10.45132976
146YES10.44097671
147PRKACG0.43938466
148MAPK110.43544918
149PTK60.43064808
150PRKACB0.40956455
151CDK150.40881005
152CAMK1D0.40649049
153RPS6KA30.40334787
154FER0.39927289
155CAMK40.39208322
156MAP2K70.39140368
157LMTK20.38620125

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.94294430
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.53650936
3Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.68603630
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.62366969
5Arginine biosynthesis_Homo sapiens_hsa002202.46716279
6Butanoate metabolism_Homo sapiens_hsa006502.29390135
7Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.23761144
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.22249406
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.16229219
10Tryptophan metabolism_Homo sapiens_hsa003802.12709851
11Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.02835779
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.00654726
13Fatty acid degradation_Homo sapiens_hsa000711.97000654
14Complement and coagulation cascades_Homo sapiens_hsa046101.96346483
15Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.94544266
16Pentose and glucuronate interconversions_Homo sapiens_hsa000401.90524497
17Histidine metabolism_Homo sapiens_hsa003401.90123559
18Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.81520480
19Peroxisome_Homo sapiens_hsa041461.78452408
20Fatty acid elongation_Homo sapiens_hsa000621.77965979
21Steroid biosynthesis_Homo sapiens_hsa001001.77442576
22Propanoate metabolism_Homo sapiens_hsa006401.76768822
23Steroid hormone biosynthesis_Homo sapiens_hsa001401.75024675
24PPAR signaling pathway_Homo sapiens_hsa033201.75007937
25Bile secretion_Homo sapiens_hsa049761.74610063
26Fatty acid metabolism_Homo sapiens_hsa012121.73020881
27Chemical carcinogenesis_Homo sapiens_hsa052041.72630877
28Sulfur metabolism_Homo sapiens_hsa009201.69047838
29Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.60215121
30Vitamin B6 metabolism_Homo sapiens_hsa007501.57950874
31Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.53667482
32Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.51909127
33beta-Alanine metabolism_Homo sapiens_hsa004101.49456326
34Retinol metabolism_Homo sapiens_hsa008301.41863790
35ABC transporters_Homo sapiens_hsa020101.18480430
36Tyrosine metabolism_Homo sapiens_hsa003501.13618624
37Phenylalanine metabolism_Homo sapiens_hsa003601.12131984
38Fatty acid biosynthesis_Homo sapiens_hsa000611.11770855
39Caffeine metabolism_Homo sapiens_hsa002321.11607633
40Pyruvate metabolism_Homo sapiens_hsa006201.06886993
41Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.06269662
42Arginine and proline metabolism_Homo sapiens_hsa003301.03950988
43Glycerolipid metabolism_Homo sapiens_hsa005611.03599170
44Fat digestion and absorption_Homo sapiens_hsa049751.01657471
45Staphylococcus aureus infection_Homo sapiens_hsa051500.99955069
46Carbohydrate digestion and absorption_Homo sapiens_hsa049730.99692638
47Vitamin digestion and absorption_Homo sapiens_hsa049770.97884651
48Starch and sucrose metabolism_Homo sapiens_hsa005000.94742245
49Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.92437779
50alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.87649681
51Insulin resistance_Homo sapiens_hsa049310.81599781
52Drug metabolism - other enzymes_Homo sapiens_hsa009830.81132648
53Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.79871524
54Platelet activation_Homo sapiens_hsa046110.79128132
55Linoleic acid metabolism_Homo sapiens_hsa005910.78168322
56Folate biosynthesis_Homo sapiens_hsa007900.77941743
57Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.77159667
58Circadian rhythm_Homo sapiens_hsa047100.77072485
59Phosphatidylinositol signaling system_Homo sapiens_hsa040700.76454754
60GABAergic synapse_Homo sapiens_hsa047270.76315353
61Cysteine and methionine metabolism_Homo sapiens_hsa002700.74839518
62Sphingolipid metabolism_Homo sapiens_hsa006000.74327898
63Ether lipid metabolism_Homo sapiens_hsa005650.73333738
64Choline metabolism in cancer_Homo sapiens_hsa052310.70884655
65Selenocompound metabolism_Homo sapiens_hsa004500.70615745
66Nicotine addiction_Homo sapiens_hsa050330.68079216
67Glutamatergic synapse_Homo sapiens_hsa047240.68064522
68B cell receptor signaling pathway_Homo sapiens_hsa046620.67395613
69Maturity onset diabetes of the young_Homo sapiens_hsa049500.65131954
70Glutathione metabolism_Homo sapiens_hsa004800.64603864
712-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.63753168
72Leukocyte transendothelial migration_Homo sapiens_hsa046700.62906846
73Vascular smooth muscle contraction_Homo sapiens_hsa042700.61390393
74Glycerophospholipid metabolism_Homo sapiens_hsa005640.60758468
75Cyanoamino acid metabolism_Homo sapiens_hsa004600.60456641
76Lysine degradation_Homo sapiens_hsa003100.60165253
77Serotonergic synapse_Homo sapiens_hsa047260.58242069
78Biosynthesis of amino acids_Homo sapiens_hsa012300.57754059
79Hepatitis C_Homo sapiens_hsa051600.56952362
80Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.56228277
81Renin secretion_Homo sapiens_hsa049240.55844660
82Carbon metabolism_Homo sapiens_hsa012000.54733180
83Renin-angiotensin system_Homo sapiens_hsa046140.51037772
84Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48819327
85Inositol phosphate metabolism_Homo sapiens_hsa005620.47849288
86Salivary secretion_Homo sapiens_hsa049700.47772763
87Type II diabetes mellitus_Homo sapiens_hsa049300.47230717
88Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.44977824
89Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.44926299
90Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.44391204
91Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.44325796
92Phospholipase D signaling pathway_Homo sapiens_hsa040720.44105865
93Osteoclast differentiation_Homo sapiens_hsa043800.44069984
94Tight junction_Homo sapiens_hsa045300.43713120
95Glycosaminoglycan degradation_Homo sapiens_hsa005310.42327596
96Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.42065039
97Mineral absorption_Homo sapiens_hsa049780.42060981
98Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.40424231
99Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.40265404
100Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.39119668
101Metabolic pathways_Homo sapiens_hsa011000.39069462
102Aldosterone synthesis and secretion_Homo sapiens_hsa049250.37292043
103Ovarian steroidogenesis_Homo sapiens_hsa049130.36865687
104Morphine addiction_Homo sapiens_hsa050320.34946669
105Leishmaniasis_Homo sapiens_hsa051400.34945832
106Tuberculosis_Homo sapiens_hsa051520.33331845
107AMPK signaling pathway_Homo sapiens_hsa041520.33014778
108Glucagon signaling pathway_Homo sapiens_hsa049220.32818573
109Notch signaling pathway_Homo sapiens_hsa043300.32638395
110Circadian entrainment_Homo sapiens_hsa047130.32576233
111Gastric acid secretion_Homo sapiens_hsa049710.32391981
112Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.32343356
113Sulfur relay system_Homo sapiens_hsa041220.31982215
114Calcium signaling pathway_Homo sapiens_hsa040200.31386509
115Hematopoietic cell lineage_Homo sapiens_hsa046400.31349940
116Pancreatic secretion_Homo sapiens_hsa049720.31348742
117Axon guidance_Homo sapiens_hsa043600.31179880
118Chemokine signaling pathway_Homo sapiens_hsa040620.30956054
119Intestinal immune network for IgA production_Homo sapiens_hsa046720.30610366
120Lysosome_Homo sapiens_hsa041420.29817082
121Prion diseases_Homo sapiens_hsa050200.29653502
122Allograft rejection_Homo sapiens_hsa053300.29033029
123Taste transduction_Homo sapiens_hsa047420.28568251
124Dorso-ventral axis formation_Homo sapiens_hsa043200.27729434
125Endocytosis_Homo sapiens_hsa041440.27680390
126Influenza A_Homo sapiens_hsa051640.27481661
127Jak-STAT signaling pathway_Homo sapiens_hsa046300.26864496
128Arachidonic acid metabolism_Homo sapiens_hsa005900.26863237
129Graft-versus-host disease_Homo sapiens_hsa053320.26680744
130Adipocytokine signaling pathway_Homo sapiens_hsa049200.25373146
131Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.24668065
132Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.22650574
133Thyroid hormone synthesis_Homo sapiens_hsa049180.21752053
134Cocaine addiction_Homo sapiens_hsa050300.20597828
135Synaptic vesicle cycle_Homo sapiens_hsa047210.20244572
136Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.20187544
137Insulin secretion_Homo sapiens_hsa049110.19728205
138Long-term depression_Homo sapiens_hsa047300.19129121
139Amphetamine addiction_Homo sapiens_hsa050310.18244991
140Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.17578165
141Fructose and mannose metabolism_Homo sapiens_hsa000510.17077755
142cAMP signaling pathway_Homo sapiens_hsa040240.16825368

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