CLN3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that is involved in lysosomal function. Mutations in this, as well as other neuronal ceroid-lipofuscinosis (CLN) genes, cause neurodegenerative diseases commonly known as Batten disease or collectively known as neuronal ceroid lipofuscinoses (NCLs). Many alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neutrophil activation involved in immune response (GO:0002283)5.52142862
2modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.49054919
3positive regulation by organism of defense response of other organism involved in symbiotic interact5.49054919
4modulation by symbiont of host immune response (GO:0052553)5.49054919
5positive regulation by symbiont of host defense response (GO:0052509)5.49054919
6modulation by symbiont of host defense response (GO:0052031)5.49054919
7modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.49054919
8response to peptidoglycan (GO:0032494)5.21215240
9respiratory burst (GO:0045730)5.14037384
10cellular extravasation (GO:0045123)4.95554128
11antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.66566817
12positive regulation of gamma-delta T cell activation (GO:0046645)4.39515512
13myeloid cell activation involved in immune response (GO:0002275)4.33776239
14indole-containing compound catabolic process (GO:0042436)4.28443654
15indolalkylamine catabolic process (GO:0046218)4.28443654
16tryptophan catabolic process (GO:0006569)4.28443654
17macrophage activation involved in immune response (GO:0002281)4.26404828
18mast cell activation (GO:0045576)4.24455236
19immunoglobulin mediated immune response (GO:0016064)4.22332786
20response to muramyl dipeptide (GO:0032495)4.14542374
21T cell migration (GO:0072678)4.02292026
22L-fucose catabolic process (GO:0042355)4.02273952
23fucose catabolic process (GO:0019317)4.02273952
24L-fucose metabolic process (GO:0042354)4.02273952
25DNA deamination (GO:0045006)3.92060789
26positive regulation of interferon-alpha production (GO:0032727)3.90337963
27granulocyte activation (GO:0036230)3.89886913
28leukocyte degranulation (GO:0043299)3.89123947
29neutrophil activation (GO:0042119)3.83941799
30regulation of B cell receptor signaling pathway (GO:0050855)3.81178548
31microglial cell activation (GO:0001774)3.75701091
32response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.74372509
33response to host immune response (GO:0052572)3.74372509
34regulation of interferon-alpha production (GO:0032647)3.71728384
35tryptophan metabolic process (GO:0006568)3.69049113
36kynurenine metabolic process (GO:0070189)3.68458526
37regulation of interferon-beta biosynthetic process (GO:0045357)3.65073102
38mast cell activation involved in immune response (GO:0002279)3.63136035
39mast cell degranulation (GO:0043303)3.63136035
40indolalkylamine metabolic process (GO:0006586)3.61433302
41regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.58241879
42cellular response to type I interferon (GO:0071357)3.54740692
43type I interferon signaling pathway (GO:0060337)3.54740692
44NIK/NF-kappaB signaling (GO:0038061)3.53857371
45cellular response to exogenous dsRNA (GO:0071360)3.51534270
46response to type I interferon (GO:0034340)3.50467738
47positive regulation of antigen processing and presentation (GO:0002579)3.44673956
48positive regulation of defense response to virus by host (GO:0002230)3.41927748
49production of molecular mediator involved in inflammatory response (GO:0002532)3.41401558
50behavioral response to nicotine (GO:0035095)3.41005744
51lymphocyte chemotaxis (GO:0048247)3.40607145
52positive regulation of B cell differentiation (GO:0045579)3.40436318
53defense response to protozoan (GO:0042832)3.38545567
54lipopolysaccharide-mediated signaling pathway (GO:0031663)3.36252138
55neutrophil mediated immunity (GO:0002446)3.35122365
56germinal center formation (GO:0002467)3.34107834
57response to host (GO:0075136)3.33230012
58response to host defenses (GO:0052200)3.33230012
59response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.33230012
60positive regulation of interferon-beta production (GO:0032728)3.30151722
61NAD biosynthetic process (GO:0009435)3.29954552
62positive regulation of cellular amide metabolic process (GO:0034250)3.29938253
63antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.27540985
64antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.27540985
65pinocytosis (GO:0006907)3.26620224
66leukocyte aggregation (GO:0070486)3.26312439
67positive regulation of mast cell activation (GO:0033005)3.25316615
68regulation of mast cell degranulation (GO:0043304)3.25011517
69superoxide anion generation (GO:0042554)3.22615387
70response to interferon-beta (GO:0035456)3.22502327
71response to protozoan (GO:0001562)3.20978211
72positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.19212187
73negative regulation of interleukin-12 production (GO:0032695)3.16985313
74interferon-gamma-mediated signaling pathway (GO:0060333)3.14405207
75macrophage activation (GO:0042116)3.14025920
76negative regulation of interleukin-1 beta production (GO:0032691)3.13127399
77B cell mediated immunity (GO:0019724)3.12396865
78natural killer cell mediated cytotoxicity (GO:0042267)3.10123981
79natural killer cell mediated immunity (GO:0002228)3.10123981
80regulation of B cell differentiation (GO:0045577)3.09442417
81negative regulation of interleukin-1 production (GO:0032692)3.09166394
82response to interferon-alpha (GO:0035455)3.08856448
83cellular response to interferon-beta (GO:0035458)3.08013528
84myeloid leukocyte activation (GO:0002274)3.07466388
85regulation of gamma-delta T cell differentiation (GO:0045586)3.04107592
86regulation of mast cell activation (GO:0033003)3.03779803
87positive regulation of mast cell degranulation (GO:0043306)3.02023470
88positive regulation of mast cell activation involved in immune response (GO:0033008)3.02023470
89mature B cell differentiation (GO:0002335)3.01840025
90antigen processing and presentation of endogenous antigen (GO:0019883)3.00141601
91regulation of mast cell activation involved in immune response (GO:0033006)2.99666823
92negative regulation of mast cell activation (GO:0033004)2.99600312
93regulation of antigen processing and presentation (GO:0002577)2.98007470
94cellular biogenic amine catabolic process (GO:0042402)2.96738255
95amine catabolic process (GO:0009310)2.96738255
96leukocyte mediated cytotoxicity (GO:0001909)2.96598937
97detection of other organism (GO:0098543)2.95390353
98regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.94974755
99T-helper 1 type immune response (GO:0042088)2.93707240
100cytidine deamination (GO:0009972)2.93499804
101cytidine metabolic process (GO:0046087)2.93499804
102cytidine catabolic process (GO:0006216)2.93499804
103positive regulation of T cell mediated cytotoxicity (GO:0001916)2.92653811
104regulation of gamma-delta T cell activation (GO:0046643)2.92636990
105B cell receptor signaling pathway (GO:0050853)2.90552387
106negative regulation of viral genome replication (GO:0045071)2.83504596
107regulation of T-helper 1 cell differentiation (GO:0045625)2.82771893
108negative regulation of cell killing (GO:0031342)2.79947406
109negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.79947406
110adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli2.79556133
111regulation of T cell mediated cytotoxicity (GO:0001914)2.79016696
112cellular ketone body metabolic process (GO:0046950)2.77937754
113regulation of interleukin-17 production (GO:0032660)2.77377820
114activated T cell proliferation (GO:0050798)2.76811938
115detection of molecule of bacterial origin (GO:0032490)2.76272650
116alkaloid metabolic process (GO:0009820)2.76222084
117hydrogen peroxide biosynthetic process (GO:0050665)2.75065167
118eosinophil chemotaxis (GO:0048245)2.74949589
119neutrophil chemotaxis (GO:0030593)2.74277110
120positive regulation of toll-like receptor signaling pathway (GO:0034123)2.73232468
121regulation of interleukin-12 biosynthetic process (GO:0045075)2.71963994
122detection of bacterium (GO:0016045)2.71704786
123positive regulation of interleukin-17 production (GO:0032740)2.68616815
124positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.68129613
125regulation of mononuclear cell migration (GO:0071675)2.67865836
126positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.67668244
127neutrophil migration (GO:1990266)2.66865960
128lymphocyte mediated immunity (GO:0002449)2.66862193
129fucosylation (GO:0036065)2.64279750
130regulation of defense response to virus by host (GO:0050691)2.63199762
131aromatic amino acid family catabolic process (GO:0009074)2.62883730
132pyridine nucleotide biosynthetic process (GO:0019363)2.62549440
133nicotinamide nucleotide biosynthetic process (GO:0019359)2.62549440
134pyrimidine ribonucleoside catabolic process (GO:0046133)2.60749310
135negative regulation of interleukin-6 production (GO:0032715)2.59824434
136interferon-gamma secretion (GO:0072643)2.59791427
137sulfation (GO:0051923)2.59302438
138drug catabolic process (GO:0042737)2.58179122
139positive regulation of triglyceride biosynthetic process (GO:0010867)2.57377568
140positive regulation of fatty acid transport (GO:2000193)2.56800405
141oxidative demethylation (GO:0070989)2.53817551
142negative T cell selection (GO:0043383)2.52255496
143phosphatidylinositol acyl-chain remodeling (GO:0036149)2.51594655
144ketone body metabolic process (GO:1902224)2.49595945
145positive regulation of prostaglandin secretion (GO:0032308)2.47018158
146reactive oxygen species biosynthetic process (GO:1903409)2.46219263
147negative regulation of innate immune response (GO:0045824)2.44463652
148detection of light stimulus involved in sensory perception (GO:0050962)2.43960071
149detection of light stimulus involved in visual perception (GO:0050908)2.43960071
150purinergic nucleotide receptor signaling pathway (GO:0035590)2.43757652
151tolerance induction (GO:0002507)2.42982395
152negative thymic T cell selection (GO:0045060)2.38936352
153indole-containing compound metabolic process (GO:0042430)2.38751247
154cellular response to interleukin-15 (GO:0071350)2.38241576
155positive regulation of calcium-mediated signaling (GO:0050850)2.37775315
156mannosylation (GO:0097502)2.37644902
157positive regulation of icosanoid secretion (GO:0032305)2.36126037
158negative regulation of telomere maintenance (GO:0032205)2.34370226
159adaptation of signaling pathway (GO:0023058)2.34352218
160positive regulation of T-helper 1 type immune response (GO:0002827)2.33271556
161regulation of leukocyte mediated cytotoxicity (GO:0001910)2.32517439
162cytokine biosynthetic process (GO:0042089)2.31244691
163negative regulation of lymphocyte mediated immunity (GO:0002707)2.29307594
164interferon-gamma production (GO:0032609)2.29215918

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.91952586
2IRF8_21731497_ChIP-ChIP_J774_Mouse5.85434283
3BP1_19119308_ChIP-ChIP_Hs578T_Human5.56607838
4IRF8_27001747_Chip-Seq_BMDM_Mouse3.99269012
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.99181201
6SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.95987531
7* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.68410880
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.42944311
9NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.41081919
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.21544099
11SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.16434301
12ZNF274_21170338_ChIP-Seq_K562_Hela3.08383338
13Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.95908525
14MYB_21317192_ChIP-Seq_ERMYB_Mouse2.93777559
15SCL_19346495_ChIP-Seq_HPC-7_Human2.87580111
16STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.69974878
17SPI1_23547873_ChIP-Seq_NB4_Human2.63804944
18STAT4_19710469_ChIP-ChIP_TH1__Mouse2.41737762
19STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.39666607
20NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.36855051
21RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.32304508
22SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.28378113
23RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.18668763
24EGR1_23403033_ChIP-Seq_LIVER_Mouse2.12608480
25BRD4_27068464_Chip-Seq_AML-cells_Mouse2.02929371
26RUNX1_22412390_ChIP-Seq_EML_Mouse2.01094624
27STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.96749196
28FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.95041676
29VDR_21846776_ChIP-Seq_THP-1_Human1.86313635
30VDR_22108803_ChIP-Seq_LS180_Human1.85975810
31VDR_24763502_ChIP-Seq_THP-1_Human1.85326972
32FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.80634931
33PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.80119536
34MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.79506829
35SPI1_23127762_ChIP-Seq_K562_Human1.77104633
36RUNX_20019798_ChIP-Seq_JUKART_Human1.76843491
37MAF_26560356_Chip-Seq_TH1_Human1.75542426
38* MYB_26560356_Chip-Seq_TH2_Human1.74816330
39PU_27001747_Chip-Seq_BMDM_Mouse1.74542608
40EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.74109737
41BCL6_27268052_Chip-Seq_Bcells_Human1.72949284
42CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.65516129
43ERA_21632823_ChIP-Seq_H3396_Human1.63739877
44MYB_26560356_Chip-Seq_TH1_Human1.63395720
45LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.61862311
46EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.61832712
47LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.58242622
48CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.57761891
49ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.51769296
50GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.50265380
51PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.49984279
52GATA2_22383799_ChIP-Seq_G1ME_Mouse1.49142936
53VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.48882761
54GATA3_21878914_ChIP-Seq_MCF-7_Human1.48029987
55RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.47380059
56* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.47216341
57CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.44142119
58E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.43209220
59BCOR_27268052_Chip-Seq_Bcells_Human1.42470946
60E2F1_20622854_ChIP-Seq_HELA_Human1.42355725
61EGR1_19374776_ChIP-ChIP_THP-1_Human1.41462971
62P300_27268052_Chip-Seq_Bcells_Human1.41424396
63RAC3_21632823_ChIP-Seq_H3396_Human1.40538724
64PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.39883089
65SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.39715885
66SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.39118679
67* PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.38622428
68TAF2_19829295_ChIP-Seq_ESCs_Human1.37084951
69ELF1_17652178_ChIP-ChIP_JURKAT_Human1.36127858
70SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.34237551
71PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.32155212
72OCT4_20526341_ChIP-Seq_ESCs_Human1.31423937
73PPARA_22158963_ChIP-Seq_LIVER_Mouse1.30964734
74GATA1_22025678_ChIP-Seq_K562_Human1.29813166
75NANOG_20526341_ChIP-Seq_ESCs_Human1.28521366
76CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.27330388
77GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.26225247
78PHF8_20622854_ChIP-Seq_HELA_Human1.25238953
79DROSHA_22980978_ChIP-Seq_HELA_Human1.24066989
80CTCF_20526341_ChIP-Seq_ESCs_Human1.23726405
81UTX_26944678_Chip-Seq_JUKART_Human1.22694717
82RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.22561414
83GATA3_26560356_Chip-Seq_TH2_Human1.21007409
84AR_20517297_ChIP-Seq_VCAP_Human1.20922878
85IKZF1_21737484_ChIP-ChIP_HCT116_Human1.20794254
86YY1_22570637_ChIP-Seq_MALME-3M_Human1.20661664
87ER_23166858_ChIP-Seq_MCF-7_Human1.20282589
88ETV2_25802403_ChIP-Seq_MESCs_Mouse1.20099568
89TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.17782733
90TP53_22573176_ChIP-Seq_HFKS_Human1.17355956
91KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.17253408
92KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.17253408
93KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.17253408
94EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.16310716
95FOXA1_25329375_ChIP-Seq_VCAP_Human1.15992196
96FOXA1_27270436_Chip-Seq_PROSTATE_Human1.15992196
97SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.14010561
98GATA1_22383799_ChIP-Seq_G1ME_Mouse1.12780652
99NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.12588818
100P53_21459846_ChIP-Seq_SAOS-2_Human1.11770533
101GATA2_21666600_ChIP-Seq_HMVEC_Human1.11702238
102ELF1_20517297_ChIP-Seq_JURKAT_Human1.11260594
103IRF1_19129219_ChIP-ChIP_H3396_Human1.09266769
104VDR_24787735_ChIP-Seq_THP-1_Human1.09251236
105P68_20966046_ChIP-Seq_HELA_Human1.09217119
106MYC_19829295_ChIP-Seq_ESCs_Human1.09056083
107FOXH1_21741376_ChIP-Seq_ESCs_Human1.07065202
108* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.06497065
109GATA3_27048872_Chip-Seq_THYMUS_Human1.06043319
110MAF_26560356_Chip-Seq_TH2_Human1.03905148
111P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.03878074
112ERG_20887958_ChIP-Seq_HPC-7_Mouse1.03385902
113NCOR_22424771_ChIP-Seq_293T_Human1.03028748
114* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.02684481
115* HOXB7_26014856_ChIP-Seq_BT474_Human1.02584388
116GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.01984021
117EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.01880892
118CEBPB_22108803_ChIP-Seq_LS180_Human1.01255269
119NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.00614739
120* TFEB_21752829_ChIP-Seq_HELA_Human1.00156065
121BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.99428553
122NOTCH1_21737748_ChIP-Seq_TLL_Human0.99327829
123GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.98855230
124* SA1_27219007_Chip-Seq_Bcells_Human0.98779447
125GATA1_19941827_ChIP-Seq_MEL_Mouse0.98639852
126PU.1_20513432_ChIP-Seq_Bcells_Mouse0.98476793
127VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.93655441
128FOXA1_21572438_ChIP-Seq_LNCaP_Human0.93581012
129TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.93212539
130SMRT_27268052_Chip-Seq_Bcells_Human0.92190378
131TCF7_22412390_ChIP-Seq_EML_Mouse0.91727237
132SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91535038
133NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.87643655
134RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.85786997
135TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.85193621
136MYC_22102868_ChIP-Seq_BL_Human0.85018336
137CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.77012305
138CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.75323406
139STAT1_20625510_ChIP-Seq_HELA_Human0.74182331
140CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.74092671
141ETS1_22383799_ChIP-Seq_G1ME_Mouse0.73238111
142SRF_21415370_ChIP-Seq_HL-1_Mouse0.72606329
143* ELK3_25401928_ChIP-Seq_HUVEC_Human0.72591407
144GATA1_19941826_ChIP-Seq_K562_Human0.71672340
145CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.69551685
146P63_26484246_Chip-Seq_KERATINOCYTES_Human0.68076171
147THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.67870559
148FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.66436934
149GATA2_19941826_ChIP-Seq_K562_Human0.66170783
150TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.65900632
151STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.65888319
152* VDR_23849224_ChIP-Seq_CD4+_Human0.64215678
153ESR1_21235772_ChIP-Seq_MCF-7_Human0.63770597
154SPI1_20517297_ChIP-Seq_HL60_Human0.62985590

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.97540360
2MP0003436_decreased_susceptibility_to3.76229860
3MP0009785_altered_susceptibility_to3.47919378
4* MP0005058_abnormal_lysosome_morphology3.33792610
5MP0002148_abnormal_hypersensitivity_rea3.19895042
6MP0002419_abnormal_innate_immunity3.18373798
7MP0006082_CNS_inflammation3.06248378
8MP0005000_abnormal_immune_tolerance3.00666117
9MP0005025_abnormal_response_to2.99099291
10MP0003195_calcinosis2.90461380
11MP0003724_increased_susceptibility_to2.84930120
12MP0005671_abnormal_response_to2.79796414
13MP0001800_abnormal_humoral_immune2.75140184
14MP0000685_abnormal_immune_system2.74959364
15MP0001790_abnormal_immune_system2.73191454
16MP0005387_immune_system_phenotype2.73191454
17MP0002452_abnormal_antigen_presenting2.70710213
18MP0005464_abnormal_platelet_physiology2.67810017
19MP0002723_abnormal_immune_serum2.62814976
20MP0001819_abnormal_immune_cell2.39969719
21MP0002420_abnormal_adaptive_immunity2.37804629
22MP0003303_peritoneal_inflammation2.35328116
23MP0008875_abnormal_xenobiotic_pharmacok2.31261701
24MP0003172_abnormal_lysosome_physiology2.16307968
25MP0009278_abnormal_bone_marrow2.07606102
26MP0001533_abnormal_skeleton_physiology1.97741925
27MP0009840_abnormal_foam_cell1.96475571
28MP0005174_abnormal_tail_pigmentation1.96180849
29MP0002653_abnormal_ependyma_morphology1.96169180
30MP0002405_respiratory_system_inflammati1.95126002
31MP0004947_skin_inflammation1.93651944
32MP0002876_abnormal_thyroid_physiology1.92103646
33MP0005365_abnormal_bile_salt1.89590730
34MP0001853_heart_inflammation1.80874063
35MP0001845_abnormal_inflammatory_respons1.80673140
36MP0000716_abnormal_immune_system1.80128965
37MP0002398_abnormal_bone_marrow1.79968522
38MP0005085_abnormal_gallbladder_physiolo1.77429279
39MP0004510_myositis1.77387554
40MP0010155_abnormal_intestine_physiology1.76414080
41MP0000569_abnormal_digit_pigmentation1.75953231
42MP0008260_abnormal_autophagy1.74191667
43MP0009333_abnormal_splenocyte_physiolog1.70292306
44MP0002396_abnormal_hematopoietic_system1.68799027
45MP0003806_abnormal_nucleotide_metabolis1.67824335
46MP0003646_muscle_fatigue1.67657536
47MP0000689_abnormal_spleen_morphology1.63824861
48MP0005397_hematopoietic_system_phenotyp1.63522797
49MP0001545_abnormal_hematopoietic_system1.63522797
50MP0008469_abnormal_protein_level1.60252485
51MP0004043_abnormal_pH_regulation1.58938745
52MP0003183_abnormal_peptide_metabolism1.57401281
53MP0005377_hearing/vestibular/ear_phenot1.54788828
54MP0003878_abnormal_ear_physiology1.54788828
55MP0002722_abnormal_immune_system1.51824195
56MP0003136_yellow_coat_color1.51444455
57MP0002429_abnormal_blood_cell1.50713997
58MP0008872_abnormal_physiological_respon1.47368838
59MP0000343_altered_response_to1.45610502
60MP0003191_abnormal_cellular_cholesterol1.44318952
61MP0002139_abnormal_hepatobiliary_system1.44090632
62MP0005360_urolithiasis1.40243128
63MP0000465_gastrointestinal_hemorrhage1.37471980
64MP0010329_abnormal_lipoprotein_level1.37380113
65MP0003763_abnormal_thymus_physiology1.35823911
66MP0003448_altered_tumor_morphology1.34531560
67MP0009764_decreased_sensitivity_to1.30783029
68MP0001851_eye_inflammation1.29456239
69MP0005551_abnormal_eye_electrophysiolog1.29274644
70MP0003075_altered_response_to1.27486259
71MP0001663_abnormal_digestive_system1.19869761
72MP0005310_abnormal_salivary_gland1.19830212
73MP0005075_abnormal_melanosome_morpholog1.18202583
74MP0000015_abnormal_ear_pigmentation1.16481117
75MP0004808_abnormal_hematopoietic_stem1.14891891
76MP0002166_altered_tumor_susceptibility1.14323226
77MP0003690_abnormal_glial_cell1.13480886
78MP0000858_altered_metastatic_potential1.13001257
79MP0001501_abnormal_sleep_pattern1.12816850
80MP0002277_abnormal_respiratory_mucosa1.11793112
81MP0002006_tumorigenesis1.10404944
82MP0002998_abnormal_bone_remodeling1.08787857
83MP0002933_joint_inflammation1.07885463
84MP0003011_delayed_dark_adaptation1.06773176
85MP0004142_abnormal_muscle_tone1.06168784
86MP0009763_increased_sensitivity_to1.05857781
87MP0000490_abnormal_crypts_of1.04404161
88MP0001873_stomach_inflammation1.04196670
89MP0000604_amyloidosis1.03229976
90MP0000703_abnormal_thymus_morphology1.03145778
91MP0001968_abnormal_touch/_nociception1.01993973
92MP0000427_abnormal_hair_cycle1.01600077
93MP0003252_abnormal_bile_duct1.00447697
94MP0002693_abnormal_pancreas_physiology0.99308566
95MP0003828_pulmonary_edema0.98220634
96MP0000371_diluted_coat_color0.97134098
97MP0009643_abnormal_urine_homeostasis0.95125218
98MP0010307_abnormal_tumor_latency0.94108849
99MP0005083_abnormal_biliary_tract0.92500916
100MP0003866_abnormal_defecation0.92399777
101MP0008961_abnormal_basal_metabolism0.92366166
102MP0005390_skeleton_phenotype0.91387052
103MP0001919_abnormal_reproductive_system0.91233455
104MP0005332_abnormal_amino_acid0.89725385
105MP0002102_abnormal_ear_morphology0.89188001
106MP0002118_abnormal_lipid_homeostasis0.89043157
107MP0004381_abnormal_hair_follicle0.86404373
108MP0000470_abnormal_stomach_morphology0.86099968
109MP0002254_reproductive_system_inflammat0.83623087
110MP0005166_decreased_susceptibility_to0.83568537
111MP0000920_abnormal_myelination0.82722373
112MP0004130_abnormal_muscle_cell0.81298846
113MP0001765_abnormal_ion_homeostasis0.81296490
114MP0003638_abnormal_response/metabolism_0.80877832
115MP0003300_gastrointestinal_ulcer0.80358578
116MP0005319_abnormal_enzyme/_coenzyme0.80178491
117MP0001485_abnormal_pinna_reflex0.76992557
118MP0003656_abnormal_erythrocyte_physiolo0.76834510
119MP0000538_abnormal_urinary_bladder0.75679189
120MP0005448_abnormal_energy_balance0.74814281
121MP0005084_abnormal_gallbladder_morpholo0.74654102
122MP0001664_abnormal_digestion0.73684302
123MP0004147_increased_porphyrin_level0.73623784
124MP0000230_abnormal_systemic_arterial0.72940747
125MP0002132_abnormal_respiratory_system0.71513491
126MP0003453_abnormal_keratinocyte_physiol0.70325894
127MP0005164_abnormal_response_to0.67100774
128MP0008057_abnormal_DNA_replication0.65766124
129MP0002095_abnormal_skin_pigmentation0.63968501
130MP0000249_abnormal_blood_vessel0.63083168
131MP0003186_abnormal_redox_activity0.62484333
132MP0003566_abnormal_cell_adhesion0.60790653
133MP0003795_abnormal_bone_structure0.60117391
134MP0005167_abnormal_blood-brain_barrier0.59203486
135MP0002019_abnormal_tumor_incidence0.58396557
136MP0005451_abnormal_body_composition0.58289211
137MP0002136_abnormal_kidney_physiology0.58030532
138MP0004782_abnormal_surfactant_physiolog0.57787006
139MP0003045_fibrosis0.56483340
140MP0009765_abnormal_xenobiotic_induced0.55527606
141MP0001986_abnormal_taste_sensitivity0.55469989
142MP0001764_abnormal_homeostasis0.54351469
143MP0002138_abnormal_hepatobiliary_system0.53422081
144MP0000367_abnormal_coat/_hair0.52917800

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)7.29948273
2Recurrent bacterial skin infections (HP:0005406)6.75536351
3Eczematoid dermatitis (HP:0000976)6.24275383
4Abnormality of macrophages (HP:0004311)5.21203802
5Recurrent gram-negative bacterial infections (HP:0005420)4.78266122
6Systemic lupus erythematosus (HP:0002725)4.72768044
7Elevated erythrocyte sedimentation rate (HP:0003565)4.38326797
8Recurrent skin infections (HP:0001581)4.22746244
9Prostate neoplasm (HP:0100787)4.22257522
10Stomatitis (HP:0010280)4.19910694
11Mediastinal lymphadenopathy (HP:0100721)4.03287138
12Chronic obstructive pulmonary disease (HP:0006510)4.00445323
13Obstructive lung disease (HP:0006536)4.00445323
14Recurrent fungal infections (HP:0002841)3.86402629
15Myositis (HP:0100614)3.83699643
16Pustule (HP:0200039)3.82169323
17* Vacuolated lymphocytes (HP:0001922)3.77752400
18Congenital stationary night blindness (HP:0007642)3.74503072
19Gingivitis (HP:0000230)3.70619648
20* Increased cerebral lipofuscin (HP:0011813)3.46159966
21Glomerulonephritis (HP:0000099)3.40158838
22* Increased neuronal autofluorescent lipopigment (HP:0002074)3.37121929
23Abnormality of liposaccharide metabolism (HP:0010968)3.36050397
24Abnormality of glycosphingolipid metabolism (HP:0004343)3.36050397
25Abnormality of glycolipid metabolism (HP:0010969)3.36050397
26Pancreatic cysts (HP:0001737)3.30838042
27Orchitis (HP:0100796)3.26462748
28Cellulitis (HP:0100658)3.22867474
29Periodontitis (HP:0000704)3.22849504
30Recurrent viral infections (HP:0004429)3.14935948
31Vasculitis (HP:0002633)3.11377353
32IgM deficiency (HP:0002850)3.10523682
33Axonal loss (HP:0003447)3.09781035
34Retrobulbar optic neuritis (HP:0100654)3.05104271
35Optic neuritis (HP:0100653)3.05104271
36Dysostosis multiplex (HP:0000943)3.02811915
37Abnormality of midbrain morphology (HP:0002418)3.02459387
38Molar tooth sign on MRI (HP:0002419)3.02459387
39Petechiae (HP:0000967)3.00882830
40Decreased electroretinogram (ERG) amplitude (HP:0000654)2.97989969
41Type II lissencephaly (HP:0007260)2.96243052
42Abnormality of the prostate (HP:0008775)2.86530947
43Recurrent cutaneous fungal infections (HP:0011370)2.81711930
44Chronic mucocutaneous candidiasis (HP:0002728)2.81711930
45Chronic otitis media (HP:0000389)2.80991980
46Agnosia (HP:0010524)2.80919137
47Interstitial pulmonary disease (HP:0006530)2.77769458
48Urticaria (HP:0001025)2.77629791
49Attenuation of retinal blood vessels (HP:0007843)2.76555107
50Meningitis (HP:0001287)2.74347496
51Decreased circulating renin level (HP:0003351)2.73944820
52Concave nail (HP:0001598)2.71168245
53Leukocytosis (HP:0001974)2.70065664
54Encephalitis (HP:0002383)2.69079575
55Hepatosplenomegaly (HP:0001433)2.67069676
56True hermaphroditism (HP:0010459)2.63583559
57Autoimmune thrombocytopenia (HP:0001973)2.63225330
58Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.61021187
59Abnormality of alanine metabolism (HP:0010916)2.61021187
60Hyperalaninemia (HP:0003348)2.61021187
61Pancreatic fibrosis (HP:0100732)2.60765754
62Clumsiness (HP:0002312)2.59917215
63Basal ganglia calcification (HP:0002135)2.57816617
64Loss of speech (HP:0002371)2.57155173
65Thick nail (HP:0001805)2.56817037
66Recurrent pneumonia (HP:0006532)2.52505426
67Osteomyelitis (HP:0002754)2.51875410
68Premature loss of primary teeth (HP:0006323)2.49948826
69Disinhibition (HP:0000734)2.49476399
70Gingival bleeding (HP:0000225)2.46914092
71Spontaneous hematomas (HP:0007420)2.44014626
72Abnormality of transition element cation homeostasis (HP:0011030)2.42451329
73Hyperventilation (HP:0002883)2.41116846
74Abnormality of the renal cortex (HP:0011035)2.40582163
75Prolonged bleeding time (HP:0003010)2.39797809
76Gastrointestinal stroma tumor (HP:0100723)2.37688931
77Abnormal rod and cone electroretinograms (HP:0008323)2.37224269
78Panhypogammaglobulinemia (HP:0003139)2.35790855
79Polydipsia (HP:0001959)2.35653700
80Abnormal drinking behavior (HP:0030082)2.35653700
81Abnormal delayed hypersensitivity skin test (HP:0002963)2.33942473
82Pulmonary infiltrates (HP:0002113)2.32039983
83Epistaxis (HP:0000421)2.32031805
84Eosinophilia (HP:0001880)2.28433075
85Nephronophthisis (HP:0000090)2.27179515
86Cerebellar dysplasia (HP:0007033)2.26681324
87Absent rod-and cone-mediated responses on ERG (HP:0007688)2.26499969
88Large for gestational age (HP:0001520)2.26168799
89Prolonged neonatal jaundice (HP:0006579)2.24804093
90Increased serum ferritin (HP:0003281)2.21571279
91Tubular atrophy (HP:0000092)2.20916781
92Cheilitis (HP:0100825)2.18866943
93Nephritis (HP:0000123)2.17752452
94Inflammation of the large intestine (HP:0002037)2.17559387
95Reticulocytopenia (HP:0001896)2.17060924
96Albinism (HP:0001022)2.15475797
97Bile duct proliferation (HP:0001408)2.15339612
98Abnormal biliary tract physiology (HP:0012439)2.15339612
99Amelogenesis imperfecta (HP:0000705)2.14706870
100T lymphocytopenia (HP:0005403)2.14033396
101Abnormality of polysaccharide metabolism (HP:0011012)2.13428003
102Abnormality of glycosaminoglycan metabolism (HP:0004371)2.13428003
103Abnormality of mucopolysaccharide metabolism (HP:0011020)2.13428003
104Urinary glycosaminoglycan excretion (HP:0003541)2.13290703
105Mucopolysacchariduria (HP:0008155)2.13290703
106Abnormality of iron homeostasis (HP:0011031)2.13100835
107Granulocytopenia (HP:0001913)2.12592345
108Abnormality of eosinophils (HP:0001879)2.12386920
109Abnormality of T cell physiology (HP:0011840)2.12121064
110Keratoconjunctivitis (HP:0001096)2.11206043
111Mesangial abnormality (HP:0001966)2.10045670
112Cystic liver disease (HP:0006706)2.09966140
113Increased IgM level (HP:0003496)2.09173787
114Colitis (HP:0002583)2.08929014
115Recurrent lower respiratory tract infections (HP:0002783)2.06017894
116Upper motor neuron abnormality (HP:0002127)2.05525804
117Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.02985599
118Abnormality of the renal medulla (HP:0100957)2.01779897
119Alkalosis (HP:0001948)2.01531787
120Abnormality of T cells (HP:0002843)2.00873522
121Gastrointestinal inflammation (HP:0004386)1.99958247
122Retinal atrophy (HP:0001105)1.99409833
123Leukopenia (HP:0001882)1.99237246
124Lymphopenia (HP:0001888)1.96376360
125Hypergammaglobulinemia (HP:0010702)1.96022863
126* Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.95062274
127Osteolytic defects of the hand bones (HP:0009699)1.94484445
128Osteolytic defects of the phalanges of the hand (HP:0009771)1.94484445
129IgG deficiency (HP:0004315)1.94363938
130Parakeratosis (HP:0001036)1.94210950
131Keratoconjunctivitis sicca (HP:0001097)1.94205742
132Severe muscular hypotonia (HP:0006829)1.93868141
133Pathologic fracture (HP:0002756)1.93385273
134Purpura (HP:0000979)1.92820016
135Thrombocytosis (HP:0001894)1.92716031
136Genetic anticipation (HP:0003743)1.92565252
137Hemoptysis (HP:0002105)1.91802227
138Ketosis (HP:0001946)1.90916174
139Abnormality of T cell number (HP:0011839)1.90776320
140Stomach cancer (HP:0012126)1.90617320
141Joint hemorrhage (HP:0005261)1.90158052
142Abnormality of cells of the lymphoid lineage (HP:0012140)1.89395760
143Increased IgE level (HP:0003212)1.88921536
144Polyuria (HP:0000103)1.88662588
145Abnormality of male internal genitalia (HP:0000022)1.88034051
146Decreased central vision (HP:0007663)1.87243115
147Hypochromic anemia (HP:0001931)1.87215938
148* Abolished electroretinogram (ERG) (HP:0000550)1.84862999
149Congenital sensorineural hearing impairment (HP:0008527)1.82550689
150Gastrointestinal infarctions (HP:0005244)1.82534762
151Abnormality of renin-angiotensin system (HP:0000847)1.81303351
152Congenital, generalized hypertrichosis (HP:0004540)1.81082269
153Autoimmune hemolytic anemia (HP:0001890)1.74694485
154Lissencephaly (HP:0001339)1.73009594
155Flat capital femoral epiphysis (HP:0003370)1.72938747
156Protruding tongue (HP:0010808)1.71252799
157Agitation (HP:0000713)1.69340818
158Cerebral palsy (HP:0100021)1.68193968

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.06730278
2BLK4.04331125
3MAP3K143.68007784
4IRAK33.66942513
5IRAK43.45215480
6MAP4K13.37059601
7KIT3.29086392
8RIPK43.20032135
9ACVR1B2.87991264
10TXK2.71718221
11TYK22.71108626
12IKBKE2.66757230
13TBK12.65789280
14TLK12.50351319
15WNK42.34641505
16TAOK32.21510250
17PIK3CG2.19015580
18JAK32.18576570
19IKBKB2.18359904
20GRK12.09035682
21BTK2.03023461
22ZAP701.96447538
23EPHB11.94649148
24ZAK1.76267543
25NME21.76220782
26MAPKAPK31.71746725
27CSK1.70866302
28CSF1R1.70143618
29TNK21.69642625
30TEC1.64724623
31JAK11.61749163
32INSRR1.60620476
33HCK1.52631710
34LCK1.50030690
35MAP2K61.49296906
36PIM21.48500974
37NUAK11.46215844
38SYK1.44815552
39LYN1.43057222
40DAPK21.42441952
41MST41.42339508
42BCKDK1.41049930
43MATK1.36168912
44CLK11.33919307
45YES11.31498229
46PBK1.29344630
47ERN11.26548515
48FGR1.25021337
49OXSR11.23095631
50MAP4K21.22749926
51CAMKK21.22526425
52CHUK1.21869017
53ADRBK11.16749245
54TESK21.11216222
55PIM11.08161105
56TGFBR21.07501895
57MAPK131.06090484
58FES1.05343797
59MAP3K131.01306269
60ITK0.99416819
61MAP2K30.97144728
62STK100.96130913
63EIF2AK20.95077811
64STK390.94362720
65PINK10.94208871
66PIK3CA0.90237416
67PRKD20.86764032
68WNK30.84180493
69GRK70.83507216
70TRPM70.79793468
71BMPR1B0.78828558
72TAOK10.78618842
73FLT30.78463325
74TGFBR10.75515112
75ADRBK20.73770498
76JAK20.73079693
77IRAK10.71919914
78NME10.71715713
79FGFR40.71635641
80EPHA30.70383338
81PTK2B0.69690195
82NEK90.66228667
83MAPK110.65614380
84KDR0.65035230
85MAP3K70.63894093
86NLK0.63349818
87PRKAA20.63020354
88STK40.62783238
89RPS6KA40.59869673
90MARK30.55393157
91PRKCD0.55357298
92EGFR0.53914293
93MAP3K30.51855971
94ABL10.49013043
95MAP3K100.48011572
96MAP3K110.45933481
97CAMKK10.44956395
98PRKCI0.43876261
99STK110.41818528
100CDK60.41589067
101FGFR30.41472224
102IRAK20.41462252
103MAPKAPK50.40568694
104SIK30.40448353
105RPS6KA60.40314531
106CAMK1D0.39501543
107SIK20.36124206
108STK380.35496761
109MAPKAPK20.34926905
110PLK40.34476826
111PTK60.34388733
112PAK40.33431491
113PDGFRB0.33384967
114RPS6KA50.33034475
115ABL20.32626596
116TAOK20.32397464
117PRKCZ0.32383375
118DAPK30.31145940
119MAPK150.31144705
120VRK10.30645854
121BMPR20.29277248
122STK160.28840200
123PRKCG0.28289408
124PRKCA0.27837080
125MAP2K20.27289839
126MUSK0.27053458
127GRK60.26921605
128RPS6KL10.26893018
129RPS6KC10.26893018
130MAPK70.26566244
131CDC42BPA0.26349400
132CDK120.26075749
133PRKG20.25716943
134HIPK20.25316123
135PRKCQ0.25002396
136FYN0.24448623
137PRPF4B0.23559180
138PDK10.23393485
139MAPK40.23318805
140IGF1R0.23232742
141MAPK30.22675493
142DYRK30.22605584
143PDPK10.21666632

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.40809362
2Leishmaniasis_Homo sapiens_hsa051402.94850531
3Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.63027287
4NF-kappa B signaling pathway_Homo sapiens_hsa040642.52897749
5Toll-like receptor signaling pathway_Homo sapiens_hsa046202.50990460
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.46791460
7Linoleic acid metabolism_Homo sapiens_hsa005912.41124350
8Osteoclast differentiation_Homo sapiens_hsa043802.35568992
9Measles_Homo sapiens_hsa051622.29723031
10Graft-versus-host disease_Homo sapiens_hsa053322.19362550
11NOD-like receptor signaling pathway_Homo sapiens_hsa046212.17165119
12* Lysosome_Homo sapiens_hsa041422.16742771
13Nitrogen metabolism_Homo sapiens_hsa009102.12924253
14Pertussis_Homo sapiens_hsa051332.07348923
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.06147734
16B cell receptor signaling pathway_Homo sapiens_hsa046622.05515681
17Legionellosis_Homo sapiens_hsa051342.02600508
18Other glycan degradation_Homo sapiens_hsa005111.99781089
19RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.97778863
20Allograft rejection_Homo sapiens_hsa053301.88817149
21Tryptophan metabolism_Homo sapiens_hsa003801.86524534
22Malaria_Homo sapiens_hsa051441.86225565
23Tuberculosis_Homo sapiens_hsa051521.86141001
24Glycosaminoglycan degradation_Homo sapiens_hsa005311.83007459
25Primary immunodeficiency_Homo sapiens_hsa053401.78084808
26Influenza A_Homo sapiens_hsa051641.77696708
27Rheumatoid arthritis_Homo sapiens_hsa053231.77129071
28Hematopoietic cell lineage_Homo sapiens_hsa046401.76418146
29Intestinal immune network for IgA production_Homo sapiens_hsa046721.73598622
30Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.67364200
31Primary bile acid biosynthesis_Homo sapiens_hsa001201.66289413
32Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.65910270
33Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.65601723
34Asthma_Homo sapiens_hsa053101.61250379
35Herpes simplex infection_Homo sapiens_hsa051681.61117333
36Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.45849209
37TNF signaling pathway_Homo sapiens_hsa046681.44506342
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.43022536
39Jak-STAT signaling pathway_Homo sapiens_hsa046301.42910501
40Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.42366175
41Toxoplasmosis_Homo sapiens_hsa051451.42282955
42Butanoate metabolism_Homo sapiens_hsa006501.40784938
43Antigen processing and presentation_Homo sapiens_hsa046121.40522131
44Phagosome_Homo sapiens_hsa041451.38402236
45Steroid hormone biosynthesis_Homo sapiens_hsa001401.33879073
46Apoptosis_Homo sapiens_hsa042101.33473355
47Chemical carcinogenesis_Homo sapiens_hsa052041.30941745
48Phototransduction_Homo sapiens_hsa047441.29115708
49Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.24833446
50Shigellosis_Homo sapiens_hsa051311.23851226
51Hepatitis C_Homo sapiens_hsa051601.21801611
52Chemokine signaling pathway_Homo sapiens_hsa040621.21448071
53Cyanoamino acid metabolism_Homo sapiens_hsa004601.20788912
54Acute myeloid leukemia_Homo sapiens_hsa052211.20293272
55Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.19387439
56Salmonella infection_Homo sapiens_hsa051321.18736961
57Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.16297448
58Sulfur relay system_Homo sapiens_hsa041221.15686833
59T cell receptor signaling pathway_Homo sapiens_hsa046601.12521544
60Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.09033078
61Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.08693565
62Maturity onset diabetes of the young_Homo sapiens_hsa049501.06066045
63Peroxisome_Homo sapiens_hsa041461.04021265
64Leukocyte transendothelial migration_Homo sapiens_hsa046700.99450029
65Hepatitis B_Homo sapiens_hsa051610.98634498
66Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.96684380
67Sulfur metabolism_Homo sapiens_hsa009200.96596436
68Sphingolipid metabolism_Homo sapiens_hsa006000.96363141
69Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.96203530
70African trypanosomiasis_Homo sapiens_hsa051430.90326524
71Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.88358882
72Glycerolipid metabolism_Homo sapiens_hsa005610.85786175
73SNARE interactions in vesicular transport_Homo sapiens_hsa041300.85165341
74Retinol metabolism_Homo sapiens_hsa008300.85083707
75Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.83475843
76Oxidative phosphorylation_Homo sapiens_hsa001900.83027421
77Caffeine metabolism_Homo sapiens_hsa002320.81901192
78Ovarian steroidogenesis_Homo sapiens_hsa049130.81505108
79Epstein-Barr virus infection_Homo sapiens_hsa051690.81341829
80Complement and coagulation cascades_Homo sapiens_hsa046100.79136891
81Autoimmune thyroid disease_Homo sapiens_hsa053200.78412122
82Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.74665855
83Fat digestion and absorption_Homo sapiens_hsa049750.74220759
84Platelet activation_Homo sapiens_hsa046110.73495159
85Type I diabetes mellitus_Homo sapiens_hsa049400.71995720
86Non-homologous end-joining_Homo sapiens_hsa034500.69939668
87Glycerophospholipid metabolism_Homo sapiens_hsa005640.69415545
88Ribosome_Homo sapiens_hsa030100.69364811
89Selenocompound metabolism_Homo sapiens_hsa004500.67945155
90Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.67224116
91AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.66492796
92Drug metabolism - other enzymes_Homo sapiens_hsa009830.65517146
93Arachidonic acid metabolism_Homo sapiens_hsa005900.65342222
94Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.65203498
95Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.64590067
96Sphingolipid signaling pathway_Homo sapiens_hsa040710.64028579
97Mineral absorption_Homo sapiens_hsa049780.63706896
98Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.62062172
99Transcriptional misregulation in cancer_Homo sapiens_hsa052020.61167095
100Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.59267201
101Chronic myeloid leukemia_Homo sapiens_hsa052200.58950087
102Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.56880859
103Fatty acid degradation_Homo sapiens_hsa000710.56176795
104Regulation of autophagy_Homo sapiens_hsa041400.56124014
105Vitamin digestion and absorption_Homo sapiens_hsa049770.56044530
106Prolactin signaling pathway_Homo sapiens_hsa049170.55974079
107Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.54600676
108Pentose and glucuronate interconversions_Homo sapiens_hsa000400.51520403
109Ether lipid metabolism_Homo sapiens_hsa005650.51509228
110PPAR signaling pathway_Homo sapiens_hsa033200.51232849
111Amoebiasis_Homo sapiens_hsa051460.50877429
112Carbohydrate digestion and absorption_Homo sapiens_hsa049730.48553806
113Collecting duct acid secretion_Homo sapiens_hsa049660.48413754
114Pancreatic cancer_Homo sapiens_hsa052120.48402505
115Folate biosynthesis_Homo sapiens_hsa007900.46301633
116Base excision repair_Homo sapiens_hsa034100.45567069
117Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.45146605
118Steroid biosynthesis_Homo sapiens_hsa001000.44659236
119Small cell lung cancer_Homo sapiens_hsa052220.44277614
120Viral myocarditis_Homo sapiens_hsa054160.43433864
121Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.42456056
122Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.41779680
123beta-Alanine metabolism_Homo sapiens_hsa004100.41614285
124Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.39920609
125ABC transporters_Homo sapiens_hsa020100.38227496
126Homologous recombination_Homo sapiens_hsa034400.37266489
127Viral carcinogenesis_Homo sapiens_hsa052030.36836373
128Neurotrophin signaling pathway_Homo sapiens_hsa047220.33611230
129One carbon pool by folate_Homo sapiens_hsa006700.32293991
130Inositol phosphate metabolism_Homo sapiens_hsa005620.31791915
131HIF-1 signaling pathway_Homo sapiens_hsa040660.30682018
132Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.28935523
133Histidine metabolism_Homo sapiens_hsa003400.28559783
134RNA polymerase_Homo sapiens_hsa030200.27620548
135Regulation of actin cytoskeleton_Homo sapiens_hsa048100.27305079
136Basal transcription factors_Homo sapiens_hsa030220.27240699
137Endocytosis_Homo sapiens_hsa041440.25340307
138Insulin resistance_Homo sapiens_hsa049310.25281851
139HTLV-I infection_Homo sapiens_hsa051660.25016917

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »