CLN6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is one of eight which have been associated with neuronal ceroid lipofuscinoses (NCL). Also referred to as Batten disease, NCL comprises a class of autosomal recessive, neurodegenerative disorders affecting children. The genes responsible likely encode proteins involved in the degradation of post-translationally modified proteins in lysosomes. The primary defect in NCL disorders is thought to be associated with lysosomal storage function. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)7.37070776
2Golgi transport vesicle coating (GO:0048200)7.37070776
3protein maturation by protein folding (GO:0022417)5.17563581
4maintenance of protein localization in endoplasmic reticulum (GO:0035437)5.07818130
5antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.79805526
6antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.79805526
7signal peptide processing (GO:0006465)4.76962674
8protein retention in ER lumen (GO:0006621)4.69165616
9ribosomal small subunit assembly (GO:0000028)4.64525610
10DNA deamination (GO:0045006)4.45308420
11sequestering of metal ion (GO:0051238)4.22973282
12SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.13349915
13protein targeting to ER (GO:0045047)4.00162661
14cotranslational protein targeting to membrane (GO:0006613)3.97576027
15endocrine pancreas development (GO:0031018)3.96047806
16retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.93845990
17antigen processing and presentation via MHC class Ib (GO:0002475)3.91748789
18COPII vesicle coating (GO:0048208)3.86715952
19establishment of protein localization to endoplasmic reticulum (GO:0072599)3.81767573
20antigen processing and presentation of endogenous antigen (GO:0019883)3.79337377
21positive regulation of nuclease activity (GO:0032075)3.77743647
22protein localization to endoplasmic reticulum (GO:0070972)3.75783545
23activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.74916897
24regulation of mammary gland epithelial cell proliferation (GO:0033599)3.73947886
25regulation of type B pancreatic cell apoptotic process (GO:2000674)3.64701706
26deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.64678209
27negative regulation of glycoprotein biosynthetic process (GO:0010561)3.63395171
28regulation of nuclease activity (GO:0032069)3.51171712
29negative regulation of erythrocyte differentiation (GO:0045647)3.50092673
30pentose metabolic process (GO:0019321)3.48996912
31endosome to melanosome transport (GO:0035646)3.47735273
32endosome to pigment granule transport (GO:0043485)3.47735273
33folic acid-containing compound biosynthetic process (GO:0009396)3.44495497
34regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.42405109
35DNA strand elongation (GO:0022616)3.42057373
36ribosomal small subunit biogenesis (GO:0042274)3.40360409
37peptide hormone processing (GO:0016486)3.38287379
38exocrine pancreas development (GO:0031017)3.35864804
39response to peptidoglycan (GO:0032494)3.34394000
40mitotic chromosome condensation (GO:0007076)3.33107520
41glandular epithelial cell differentiation (GO:0002067)3.32845877
42GDP-mannose metabolic process (GO:0019673)3.31557337
43mannose metabolic process (GO:0006013)3.31044926
44rRNA transcription (GO:0009303)3.30801464
45pteridine-containing compound biosynthetic process (GO:0042559)3.28469529
46peptidyl-arginine omega-N-methylation (GO:0035247)3.27459523
47telomere maintenance via semi-conservative replication (GO:0032201)3.26511297
48amyloid precursor protein catabolic process (GO:0042987)3.24712549
49folic acid metabolic process (GO:0046655)3.24594765
50DNA strand elongation involved in DNA replication (GO:0006271)3.22472532
51negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.20869893
52NIK/NF-kappaB signaling (GO:0038061)3.18430242
53endoplasmic reticulum unfolded protein response (GO:0030968)3.17617179
54cellular response to topologically incorrect protein (GO:0035967)3.13736343
55negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.13605930
56viral transcription (GO:0019083)3.11056048
57cellular response to unfolded protein (GO:0034620)3.10251983
58pinocytosis (GO:0006907)3.08294028
59protein autoprocessing (GO:0016540)3.05570104
60IMP biosynthetic process (GO:0006188)3.03085869
61L-alpha-amino acid transmembrane transport (GO:1902475)3.02806838
62spliceosomal tri-snRNP complex assembly (GO:0000244)2.98745051
63protein N-linked glycosylation via asparagine (GO:0018279)2.97473127
64histone arginine methylation (GO:0034969)2.96027840
65translational termination (GO:0006415)2.96004091
66peptidyl-asparagine modification (GO:0018196)2.95732651
67regulation of translational fidelity (GO:0006450)2.93072682
68glandular epithelial cell development (GO:0002068)2.90804045
69pseudouridine synthesis (GO:0001522)2.89096333
70heterochromatin organization (GO:0070828)2.85996742
71translational elongation (GO:0006414)2.85535053
72ER-nucleus signaling pathway (GO:0006984)2.85417288
73glycosphingolipid catabolic process (GO:0046479)2.85142187
74positive regulation of insulin secretion (GO:0032024)2.84964739
75viral mRNA export from host cell nucleus (GO:0046784)2.82726148
76ribosome biogenesis (GO:0042254)2.82244536
77apoptotic process involved in morphogenesis (GO:0060561)2.81707566
78pentose-phosphate shunt (GO:0006098)2.81124599
79purine-containing compound salvage (GO:0043101)2.80019974
80amino sugar catabolic process (GO:0046348)2.79918346
81fucose metabolic process (GO:0006004)2.79301926
82glycoside metabolic process (GO:0016137)2.78820091
83tricarboxylic acid metabolic process (GO:0072350)2.78522614
84type B pancreatic cell development (GO:0003323)2.78128183
85telomere maintenance via recombination (GO:0000722)2.76053302
86DNA replication checkpoint (GO:0000076)2.72398938
87ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.72269227
883-UTR-mediated mRNA stabilization (GO:0070935)2.72231094
89nucleobase biosynthetic process (GO:0046112)2.71784966
90regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.71296846
91protein N-linked glycosylation (GO:0006487)2.67851911
92T cell apoptotic process (GO:0070231)2.67167440
93post-embryonic morphogenesis (GO:0009886)2.66825255
94mitotic nuclear envelope reassembly (GO:0007084)2.65766359
95nuclear envelope reassembly (GO:0031468)2.65766359
96N-acetylneuraminate metabolic process (GO:0006054)2.63852979
97vesicle coating (GO:0006901)2.62724283
98translesion synthesis (GO:0019985)2.62594170
99modulation by virus of host process (GO:0019054)2.62497298
100protein targeting to membrane (GO:0006612)2.62265663
101proline biosynthetic process (GO:0006561)2.61274494
102definitive hemopoiesis (GO:0060216)2.61265316
103mitotic sister chromatid segregation (GO:0000070)2.61029366
104DNA unwinding involved in DNA replication (GO:0006268)2.60864383
105peptide catabolic process (GO:0043171)2.59115871
106UTP biosynthetic process (GO:0006228)2.58782926
107negative regulation of viral release from host cell (GO:1902187)2.56853737
108pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.56333805
109negative regulation of bone resorption (GO:0045779)2.55739913
110pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.55260371
111ncRNA 3-end processing (GO:0043628)2.55125475
112IMP metabolic process (GO:0046040)2.55055426
113ribonucleoprotein complex biogenesis (GO:0022613)2.55004670
114misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.54209142
115negative regulation of glycoprotein metabolic process (GO:1903019)2.53740153
116maturation of SSU-rRNA (GO:0030490)2.52801910
117negative regulation of mRNA processing (GO:0050686)2.52591201
118tRNA methylation (GO:0030488)2.52527567
119regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.52045050
120pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.51496605
121transcription from mitochondrial promoter (GO:0006390)2.50366558
122positive regulation of transcription regulatory region DNA binding (GO:2000679)2.50134088
123telomere maintenance via telomere lengthening (GO:0010833)2.50069768
124viral life cycle (GO:0019058)2.49624791
125Arp2/3 complex-mediated actin nucleation (GO:0034314)2.49326295
126negative regulation of cell size (GO:0045792)2.49266603
127snRNA metabolic process (GO:0016073)2.48799833
128peptidyl-arginine methylation (GO:0018216)2.48713212
129peptidyl-arginine N-methylation (GO:0035246)2.48713212
130mitochondrial RNA metabolic process (GO:0000959)2.48014762
131negative regulation of mRNA metabolic process (GO:1903312)2.47952020
132intracellular estrogen receptor signaling pathway (GO:0030520)2.47846699
133glycolipid catabolic process (GO:0019377)2.47172263
134DNA duplex unwinding (GO:0032508)2.46998677
135DNA replication initiation (GO:0006270)2.46718438
136response to thyroid hormone (GO:0097066)2.46502980
137megakaryocyte development (GO:0035855)2.45837314
138antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.45369562
139L-serine metabolic process (GO:0006563)2.45025630
140nuclear pore complex assembly (GO:0051292)2.44920152
141pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.44439060
142mitotic recombination (GO:0006312)2.43004219
143nucleoside diphosphate catabolic process (GO:0009134)2.42606130
144nucleotide salvage (GO:0043173)2.41602600
145regulation of translational termination (GO:0006449)2.41554518
146pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.40767724
147fucosylation (GO:0036065)2.39829855
148response to endoplasmic reticulum stress (GO:0034976)2.39376413
149chromatin assembly (GO:0031497)2.37509438
150mitotic nuclear envelope disassembly (GO:0007077)2.37412009
151mitochondrial calcium ion transport (GO:0006851)2.37089157
152modulation by symbiont of host cellular process (GO:0044068)2.35649144
153cellular response to vitamin D (GO:0071305)2.35150844
154protein complex localization (GO:0031503)2.34956664
155chaperone mediated protein folding requiring cofactor (GO:0051085)2.34781250
156NADPH regeneration (GO:0006740)2.33690807
157nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.33668037
158gonadal mesoderm development (GO:0007506)2.32523997
159positive regulation of lymphocyte apoptotic process (GO:0070230)2.32312346
160purine nucleotide salvage (GO:0032261)2.32301736
161response to unfolded protein (GO:0006986)2.30785448
162DNA geometric change (GO:0032392)2.30567745
163positive regulation by symbiont of host defense response (GO:0052509)2.30344701
164modulation by symbiont of host defense response (GO:0052031)2.30344701
165modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.30344701
166modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.30344701
167positive regulation by organism of defense response of other organism involved in symbiotic interact2.30344701
168modulation by symbiont of host immune response (GO:0052553)2.30344701
169regulation of apoptotic process involved in morphogenesis (GO:1902337)2.30274065
170response to topologically incorrect protein (GO:0035966)2.30183439
171protein localization to chromosome, centromeric region (GO:0071459)2.30171992
172formation of translation preinitiation complex (GO:0001731)2.30159114
173negative regulation of RNA splicing (GO:0033119)2.28243344
174translational initiation (GO:0006413)2.27455368
175regulation of superoxide anion generation (GO:0032928)2.27042462
176glucose catabolic process (GO:0006007)2.26937180
177regulation of chromatin binding (GO:0035561)2.26630183
178response to interferon-beta (GO:0035456)2.26624583
179nucleobase-containing small molecule interconversion (GO:0015949)2.26549195
180lymphocyte apoptotic process (GO:0070227)2.25852541
181regulation of erythrocyte differentiation (GO:0045646)2.25565916
182response to misfolded protein (GO:0051788)2.20250286
183translation (GO:0006412)2.19407733
184RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.18730846
185immunoglobulin mediated immune response (GO:0016064)2.16508180

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.97710089
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.29921827
3ELF1_17652178_ChIP-ChIP_JURKAT_Human2.74488056
4SCL_19346495_ChIP-Seq_HPC-7_Human2.66657977
5* MYC_22102868_ChIP-Seq_BL_Human2.60892106
6MYC_18555785_ChIP-Seq_MESCs_Mouse2.49738099
7EGR1_19374776_ChIP-ChIP_THP-1_Human2.46886470
8SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.45063728
9IRF8_22096565_ChIP-ChIP_GC-B_Human2.43456535
10TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.36640452
11RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.24350544
12VDR_21846776_ChIP-Seq_THP-1_Human2.15288015
13GATA1_22025678_ChIP-Seq_K562_Human2.14203672
14* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.12008319
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.06064507
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.04917832
17FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.03648512
18SFPI1_20887958_ChIP-Seq_HPC-7_Mouse2.01354056
19ERG_20887958_ChIP-Seq_HPC-7_Mouse2.00329297
20PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.95836425
21MYC_18358816_ChIP-ChIP_MESCs_Mouse1.93085907
22HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.92431598
23DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.87176246
24EST1_17652178_ChIP-ChIP_JURKAT_Human1.78664065
25MYB_21317192_ChIP-Seq_ERMYB_Mouse1.74088643
26MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.73430570
27TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.73320479
28MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.72912049
29ELK3_25401928_ChIP-Seq_HUVEC_Human1.72739473
30KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.71515128
31NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.71508765
32KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.71084523
33IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.70566917
34TFEB_21752829_ChIP-Seq_HELA_Human1.70038152
35SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.69582520
36FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.69098812
37PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.68601873
38SPI1_23547873_ChIP-Seq_NB4_Human1.68498295
39ETS1_20019798_ChIP-Seq_JURKAT_Human1.66463021
40GATA1_22383799_ChIP-Seq_G1ME_Mouse1.66154387
41VDR_23849224_ChIP-Seq_CD4+_Human1.64246768
42CIITA_25753668_ChIP-Seq_RAJI_Human1.63872533
43FOXM1_23109430_ChIP-Seq_U2OS_Human1.61452464
44MYC_19030024_ChIP-ChIP_MESCs_Mouse1.61417192
45FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.59726483
46GABP_19822575_ChIP-Seq_HepG2_Human1.59679103
47PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.59413719
48* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.59359956
49GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.58925716
50FOXP3_21729870_ChIP-Seq_TREG_Human1.58763405
51ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.58612813
52RACK7_27058665_Chip-Seq_MCF-7_Human1.57007935
53XRN2_22483619_ChIP-Seq_HELA_Human1.54701114
54HOXB4_20404135_ChIP-ChIP_EML_Mouse1.53892865
55E2F1_18555785_ChIP-Seq_MESCs_Mouse1.51447500
56TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.51224521
57FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.50683359
58LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.47424508
59VDR_24763502_ChIP-Seq_THP-1_Human1.47143741
60LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.46903589
61P68_20966046_ChIP-Seq_HELA_Human1.45487814
62MYC_19079543_ChIP-ChIP_MESCs_Mouse1.44885949
63ZNF263_19887448_ChIP-Seq_K562_Human1.44170952
64TET1_21451524_ChIP-Seq_MESCs_Mouse1.43637041
65DCP1A_22483619_ChIP-Seq_HELA_Human1.42331456
66KDM2B_26808549_Chip-Seq_SUP-B15_Human1.41913484
67E2F1_21310950_ChIP-Seq_MCF-7_Human1.41774450
68* TCF7_22412390_ChIP-Seq_EML_Mouse1.39433938
69E2F4_17652178_ChIP-ChIP_JURKAT_Human1.38649883
70RUNX1_22412390_ChIP-Seq_EML_Mouse1.37723538
71CREB1_15753290_ChIP-ChIP_HEK293T_Human1.37236258
72NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.36413549
73SRF_21415370_ChIP-Seq_HL-1_Mouse1.35325528
74NELFA_20434984_ChIP-Seq_ESCs_Mouse1.35318435
75TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.34645900
76NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.32261390
77CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.32106095
78MYB_26560356_Chip-Seq_TH2_Human1.31140845
79MAF_26560356_Chip-Seq_TH2_Human1.31037179
80BRD4_27068464_Chip-Seq_AML-cells_Mouse1.29339930
81UTX_26944678_Chip-Seq_JUKART_Human1.28528515
82STAT3_1855785_ChIP-Seq_MESCs_Mouse1.28458678
83CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.28056199
84ELF1_20517297_ChIP-Seq_JURKAT_Human1.26967333
85E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.25721891
86CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.25544767
87KLF4_18555785_ChIP-Seq_MESCs_Mouse1.25430963
88KDM2B_26808549_Chip-Seq_DND41_Human1.25154533
89MAF_26560356_Chip-Seq_TH1_Human1.23947229
90NCOR1_26117541_ChIP-Seq_K562_Human1.21427568
91CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.21228006
92MYB_26560356_Chip-Seq_TH1_Human1.20350795
93GATA2_22383799_ChIP-Seq_G1ME_Mouse1.18451542
94GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.16971561
95* BCOR_27268052_Chip-Seq_Bcells_Human1.16963242
96SA1_27219007_Chip-Seq_ERYTHROID_Human1.16200010
97ESR1_15608294_ChIP-ChIP_MCF-7_Human1.16154987
98KDM5A_27292631_Chip-Seq_BREAST_Human1.15446146
99MYCN_18555785_ChIP-Seq_MESCs_Mouse1.14717868
100BCL6_27268052_Chip-Seq_Bcells_Human1.14506816
101KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.13797543
102CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.13593587
103TTF2_22483619_ChIP-Seq_HELA_Human1.12224415
104THAP11_20581084_ChIP-Seq_MESCs_Mouse1.12191479
105CTCF_26484167_Chip-Seq_Bcells_Mouse1.11635927
106SPI1_23127762_ChIP-Seq_K562_Human1.10883655
107CTCF_27219007_Chip-Seq_ERYTHROID_Human1.10437424
108POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.10409688
109BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.10122603
110SRY_22984422_ChIP-ChIP_TESTIS_Rat1.09963223
111KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.08673903
112* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.08497112
113DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.07999747
114CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.07986381
115NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.07285070
116SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.06449063
117CTCF_18555785_ChIP-Seq_MESCs_Mouse1.06104267
118IRF8_21731497_ChIP-ChIP_J774_Mouse1.05193753
119SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.05110373
120YY1_21170310_ChIP-Seq_MESCs_Mouse1.03888434
121PU.1_20513432_ChIP-Seq_Bcells_Mouse1.02985324
122NANOG_18555785_ChIP-Seq_MESCs_Mouse1.02025552
123LXR_22292898_ChIP-Seq_THP-1_Human1.00828910
124PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97436502
125ATF3_27146783_Chip-Seq_COLON_Human0.96645355
126CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.96479546
127STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.96460183
128STAT4_19710469_ChIP-ChIP_TH1__Mouse0.96243931
129ELK1_19687146_ChIP-ChIP_HELA_Human0.96007201
130FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.95950396
131SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.95157012
132CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.94828158
133PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.93462822
134ETS1_22383799_ChIP-Seq_G1ME_Mouse0.93085507

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002877_abnormal_melanocyte_morpholog4.78890372
2MP0005451_abnormal_body_composition2.97065104
3MP0002693_abnormal_pancreas_physiology2.90455938
4MP0003183_abnormal_peptide_metabolism2.85930829
5MP0001944_abnormal_pancreas_morphology2.53557362
6MP0005220_abnormal_exocrine_pancreas2.51137554
7MP0006054_spinal_hemorrhage2.50069645
8MP0005058_abnormal_lysosome_morphology2.46327227
9MP0005076_abnormal_cell_differentiation2.34404364
10MP0004264_abnormal_extraembryonic_tissu2.31978474
11MP0003172_abnormal_lysosome_physiology2.30760353
12MP0003300_gastrointestinal_ulcer2.29606799
13MP0003283_abnormal_digestive_organ2.29108731
14MP0003303_peritoneal_inflammation2.21353810
15MP0004043_abnormal_pH_regulation2.21268008
16MP0000678_abnormal_parathyroid_gland2.16617257
17MP0003705_abnormal_hypodermis_morpholog2.10528991
18MP0003693_abnormal_embryo_hatching2.09850049
19MP0003806_abnormal_nucleotide_metabolis2.08441545
20MP0002396_abnormal_hematopoietic_system2.05958975
21MP0004185_abnormal_adipocyte_glucose2.04321309
22MP0003866_abnormal_defecation1.87427732
23MP0005174_abnormal_tail_pigmentation1.86892595
24MP0002254_reproductive_system_inflammat1.81535551
25MP0000490_abnormal_crypts_of1.78663231
26MP0001986_abnormal_taste_sensitivity1.72908672
27MP0000465_gastrointestinal_hemorrhage1.71367225
28MP0001873_stomach_inflammation1.70379556
29MP0001661_extended_life_span1.67256043
30MP0005464_abnormal_platelet_physiology1.65831215
31MP0002909_abnormal_adrenal_gland1.65350135
32MP0004808_abnormal_hematopoietic_stem1.64803648
33MP0005379_endocrine/exocrine_gland_phen1.62981003
34MP0010386_abnormal_urinary_bladder1.58411106
35MP0010094_abnormal_chromosome_stability1.58228439
36MP0001835_abnormal_antigen_presentation1.53707452
37MP0003436_decreased_susceptibility_to1.51774593
38MP0003763_abnormal_thymus_physiology1.50741485
39MP0010352_gastrointestinal_tract_polyps1.49977015
40MP0008932_abnormal_embryonic_tissue1.47925791
41MP0005397_hematopoietic_system_phenotyp1.47830601
42MP0001545_abnormal_hematopoietic_system1.47830601
43MP0000013_abnormal_adipose_tissue1.46526969
44MP0003724_increased_susceptibility_to1.45841156
45MP0009333_abnormal_splenocyte_physiolog1.43721009
46MP0004957_abnormal_blastocyst_morpholog1.42774451
47MP0000685_abnormal_immune_system1.41277029
48MP0004233_abnormal_muscle_weight1.40122871
49MP0008057_abnormal_DNA_replication1.40041455
50MP0003453_abnormal_keratinocyte_physiol1.38617773
51MP0002078_abnormal_glucose_homeostasis1.34926257
52MP0001730_embryonic_growth_arrest1.34692750
53MP0001849_ear_inflammation1.34182910
54MP0009643_abnormal_urine_homeostasis1.34049236
55MP0008007_abnormal_cellular_replicative1.33576430
56MP0005000_abnormal_immune_tolerance1.26175742
57MP0005671_abnormal_response_to1.25375055
58MP0002398_abnormal_bone_marrow1.24829751
59MP0002166_altered_tumor_susceptibility1.24017797
60MP0000350_abnormal_cell_proliferation1.23485451
61MP0005025_abnormal_response_to1.21822383
62MP0002928_abnormal_bile_duct1.20213570
63MP0009785_altered_susceptibility_to1.19990469
64MP0008260_abnormal_autophagy1.19028135
65MP0003077_abnormal_cell_cycle1.17710343
66MP0002139_abnormal_hepatobiliary_system1.17590798
67MP0006036_abnormal_mitochondrial_physio1.15830410
68MP0000015_abnormal_ear_pigmentation1.15295318
69MP0003111_abnormal_nucleus_morphology1.14398693
70MP0003195_calcinosis1.12164357
71MP0009780_abnormal_chondrocyte_physiolo1.12116433
72MP0003786_premature_aging1.11962005
73MP0001853_heart_inflammation1.11955574
74MP0005075_abnormal_melanosome_morpholog1.11834269
75MP0005310_abnormal_salivary_gland1.11390949
76MP0010155_abnormal_intestine_physiology1.10229736
77MP0002722_abnormal_immune_system1.08182122
78MP0009672_abnormal_birth_weight1.07456042
79MP0002148_abnormal_hypersensitivity_rea1.05728970
80MP0006072_abnormal_retinal_apoptosis1.05251318
81MP0002420_abnormal_adaptive_immunity1.04614292
82MP0008058_abnormal_DNA_repair1.04533767
83MP0002723_abnormal_immune_serum1.04386085
84MP0002163_abnormal_gland_morphology1.03393174
85MP0003943_abnormal_hepatobiliary_system1.03382622
86MP0002429_abnormal_blood_cell1.02811579
87MP0001765_abnormal_ion_homeostasis1.02597197
88MP0001819_abnormal_immune_cell1.02586426
89MP0002419_abnormal_innate_immunity1.01243760
90MP0000689_abnormal_spleen_morphology1.01217837
91MP0001845_abnormal_inflammatory_respons1.00356589
92MP0002405_respiratory_system_inflammati1.00350140
93MP0000716_abnormal_immune_system0.99841958
94MP0009840_abnormal_foam_cell0.99237080
95MP0000313_abnormal_cell_death0.99210273
96MP0000703_abnormal_thymus_morphology0.96543283
97MP0005636_abnormal_mineral_homeostasis0.96380012
98MP0001790_abnormal_immune_system0.95300745
99MP0005387_immune_system_phenotype0.95300745
100MP0002019_abnormal_tumor_incidence0.94866706
101MP0002452_abnormal_antigen_presenting0.94679002
102MP0000358_abnormal_cell_content/0.94082627
103MP0002080_prenatal_lethality0.93720744
104MP0005083_abnormal_biliary_tract0.92733713
105MP0002796_impaired_skin_barrier0.92410836
106MP0002095_abnormal_skin_pigmentation0.92349566
107MP0004858_abnormal_nervous_system0.92071312
108MP0005501_abnormal_skin_physiology0.91947500
109MP0002638_abnormal_pupillary_reflex0.91368234
110MP0010307_abnormal_tumor_latency0.90801871
111MP0000371_diluted_coat_color0.90380523
112MP0009278_abnormal_bone_marrow0.90202885
113MP0002132_abnormal_respiratory_system0.88713016
114MP0001800_abnormal_humoral_immune0.88683317
115MP0006082_CNS_inflammation0.87986335
116MP0002075_abnormal_coat/hair_pigmentati0.86584541
117MP0008961_abnormal_basal_metabolism0.86206059
118MP0000858_altered_metastatic_potential0.86092513
119MP0003566_abnormal_cell_adhesion0.86073946
120MP0004381_abnormal_hair_follicle0.85156982
121MP0004782_abnormal_surfactant_physiolog0.85127697
122MP0005380_embryogenesis_phenotype0.84805081
123MP0001672_abnormal_embryogenesis/_devel0.84805081
124MP0006035_abnormal_mitochondrial_morpho0.83884446
125MP0000003_abnormal_adipose_tissue0.83293178
126MP0001756_abnormal_urination0.83189683
127MP0001270_distended_abdomen0.82531432
128MP0008469_abnormal_protein_level0.81889603
129MP0001533_abnormal_skeleton_physiology0.81878735
130MP0003984_embryonic_growth_retardation0.81719795
131MP0005666_abnormal_adipose_tissue0.81036529
132MP0009931_abnormal_skin_appearance0.80546471
133MP0001697_abnormal_embryo_size0.80148974
134MP0002006_tumorigenesis0.79746397
135MP0002837_dystrophic_cardiac_calcinosis0.78980295
136MP0000609_abnormal_liver_physiology0.78137471
137MP0000613_abnormal_salivary_gland0.77699533
138MP0002089_abnormal_postnatal_growth/wei0.76942162
139MP0003656_abnormal_erythrocyte_physiolo0.75196486
140MP0005257_abnormal_intraocular_pressure0.75050347
141MP0001216_abnormal_epidermal_layer0.74944245
142MP0004947_skin_inflammation0.74683511

Predicted human phenotypes

RankGene SetZ-score
1Hypoglycemic coma (HP:0001325)4.67681510
2* Increased cerebral lipofuscin (HP:0011813)4.58855107
3Hyperinsulinemic hypoglycemia (HP:0000825)4.57486950
4* Increased neuronal autofluorescent lipopigment (HP:0002074)4.48014603
5Hypoglycemic seizures (HP:0002173)4.43184523
6Mucopolysacchariduria (HP:0008155)4.26694636
7Urinary glycosaminoglycan excretion (HP:0003541)4.26694636
8Symptomatic seizures (HP:0011145)4.11494590
9Generalized aminoaciduria (HP:0002909)4.06250376
10Dysostosis multiplex (HP:0000943)4.02881139
11Abnormality of mucopolysaccharide metabolism (HP:0011020)3.86249335
12Abnormality of polysaccharide metabolism (HP:0011012)3.86249335
13Abnormality of glycosaminoglycan metabolism (HP:0004371)3.86249335
14Chromosomal breakage induced by crosslinking agents (HP:0003221)3.79336063
15Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.52356170
16Type I transferrin isoform profile (HP:0003642)3.52216775
17Thrombocytosis (HP:0001894)3.46383259
18Vacuolated lymphocytes (HP:0001922)3.38626065
19Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.33843117
20Abnormal protein N-linked glycosylation (HP:0012347)3.33843117
21Abnormal protein glycosylation (HP:0012346)3.33843117
22Abnormal glycosylation (HP:0012345)3.33843117
23Chromsome breakage (HP:0040012)3.32505775
24Abnormality of the pancreatic islet cells (HP:0006476)3.29397151
25Abnormality of endocrine pancreas physiology (HP:0012093)3.29397151
26Aplasia/Hypoplasia of the sacrum (HP:0008517)3.28007440
27Loss of speech (HP:0002371)3.22547114
28Abnormal number of erythroid precursors (HP:0012131)3.21634586
29Aplastic anemia (HP:0001915)3.15495185
30Late onset (HP:0003584)3.14331904
3111 pairs of ribs (HP:0000878)3.11385513
32Abnormality of cells of the erythroid lineage (HP:0012130)3.08905716
33Large for gestational age (HP:0001520)2.99017781
34Pancreatic islet-cell hyperplasia (HP:0004510)2.96244534
35Decreased circulating renin level (HP:0003351)2.86184534
36Recurrent bacterial skin infections (HP:0005406)2.84158553
37Broad distal phalanx of finger (HP:0009836)2.83634485
38Ragged-red muscle fibers (HP:0003200)2.82278505
39IgM deficiency (HP:0002850)2.75639652
40Insulin-resistant diabetes mellitus (HP:0000831)2.74692770
41Progressive neurologic deterioration (HP:0002344)2.71085054
42Petechiae (HP:0000967)2.69861301
43Ketoacidosis (HP:0001993)2.67648269
44Recurrent viral infections (HP:0004429)2.63424658
45Hyperacusis (HP:0010780)2.63218452
46Abnormality of T cell physiology (HP:0011840)2.60465931
47Thoracic kyphosis (HP:0002942)2.57230581
48Multiple enchondromatosis (HP:0005701)2.55081764
49Increased serum ferritin (HP:0003281)2.50167023
50Abnormal delayed hypersensitivity skin test (HP:0002963)2.49353806
51Abnormality of the thoracic spine (HP:0100711)2.48848456
52Autoimmune thrombocytopenia (HP:0001973)2.45903439
53Microvesicular hepatic steatosis (HP:0001414)2.45437680
54Chronic obstructive pulmonary disease (HP:0006510)2.41837637
55Obstructive lung disease (HP:0006536)2.41837637
56Chronic otitis media (HP:0000389)2.40139405
57Absent rod-and cone-mediated responses on ERG (HP:0007688)2.37007999
58Hypertensive crisis (HP:0100735)2.35005808
59Abnormality of pyrimidine metabolism (HP:0004353)2.34290108
60Insulin resistance (HP:0000855)2.33528618
61Acute lymphatic leukemia (HP:0006721)2.31974835
62Abnormal pancreas size (HP:0012094)2.31901625
63Beaking of vertebral bodies (HP:0004568)2.31770992
64Hyperglycemia (HP:0003074)2.31518915
65Abnormality of calcium-phosphate metabolism (HP:0100530)2.31237525
66J-shaped sella turcica (HP:0002680)2.28270695
67Reticulocytopenia (HP:0001896)2.26258739
68Vertebral compression fractures (HP:0002953)2.25096208
69Reduced antithrombin III activity (HP:0001976)2.24662763
70Interstitial pulmonary disease (HP:0006530)2.21927163
71Thoracolumbar scoliosis (HP:0002944)2.20463778
72Poor head control (HP:0002421)2.20166077
73Testicular atrophy (HP:0000029)2.19957710
74Achilles tendon contracture (HP:0001771)2.17408476
75Elevated erythrocyte sedimentation rate (HP:0003565)2.17034263
76Abnormality of glycolipid metabolism (HP:0010969)2.14971400
77Abnormality of liposaccharide metabolism (HP:0010968)2.14971400
78Abnormality of glycosphingolipid metabolism (HP:0004343)2.14971400
79Abnormality of macrophages (HP:0004311)2.14031564
80Abnormality of the nasal mucosa (HP:0000433)2.13125372
81Birth length less than 3rd percentile (HP:0003561)2.12855465
82Nasal polyposis (HP:0100582)2.12550183
83Hypergonadotropic hypogonadism (HP:0000815)2.11321651
84Abnormality of the anterior horn cell (HP:0006802)2.08029712
85Degeneration of anterior horn cells (HP:0002398)2.08029712
86Pseudobulbar signs (HP:0002200)2.05862541
87Progressive muscle weakness (HP:0003323)2.05134540
88Upper motor neuron abnormality (HP:0002127)2.04925697
89Nonimmune hydrops fetalis (HP:0001790)2.03687250
90Hypokalemia (HP:0002900)2.02977655
91Breast hypoplasia (HP:0003187)2.02891429
92Hyperparathyroidism (HP:0000843)2.02262948
93Retinal atrophy (HP:0001105)2.01961833
94Missing ribs (HP:0000921)2.01571347
95Prolonged bleeding time (HP:0003010)2.01563181
96Abnormal rod and cone electroretinograms (HP:0008323)1.99219800
97Abnormality of reticulocytes (HP:0004312)1.97869444
98Hyperactive renin-angiotensin system (HP:0000841)1.97668276
99Hepatic necrosis (HP:0002605)1.97427455
100Chronic bronchitis (HP:0004469)1.96512680
101Prominent metopic ridge (HP:0005487)1.95600288
102Rough bone trabeculation (HP:0100670)1.93644705
103Limb hypertonia (HP:0002509)1.93399495
104Cortical visual impairment (HP:0100704)1.91816480
105Albinism (HP:0001022)1.91608537
106Septate vagina (HP:0001153)1.90516509
107Aplasia/Hypoplasia of the thymus (HP:0010515)1.88735139
108Mediastinal lymphadenopathy (HP:0100721)1.88659079
109Fatigue (HP:0012378)1.88057647
110Hepatosplenomegaly (HP:0001433)1.87733188
111* Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.87228781
112Abnormality of the Achilles tendon (HP:0005109)1.87149667
113Trismus (HP:0000211)1.85639130
114Broad face (HP:0000283)1.85545088
115Ureteral duplication (HP:0000073)1.84719622
116Prolonged neonatal jaundice (HP:0006579)1.82834471
117Abnormality of the preputium (HP:0100587)1.82276327
118Bronchitis (HP:0012387)1.81680989
119Type II lissencephaly (HP:0007260)1.81655083
120Severe short stature (HP:0003510)1.81648374
121Pallor (HP:0000980)1.81118664
122Cerebellar dysplasia (HP:0007033)1.80754749
123Abnormality of the heme biosynthetic pathway (HP:0010472)1.80074830
124Truncus arteriosus (HP:0001660)1.79925663
125Hypothermia (HP:0002045)1.78774664
126Impaired platelet aggregation (HP:0003540)1.78593880
127Abnormal platelet function (HP:0011869)1.78593880
128Abnormality of iron homeostasis (HP:0011031)1.78037225
129Abnormal trabecular bone morphology (HP:0100671)1.77397135
130Hypokinesia (HP:0002375)1.76978113
131Asymmetric septal hypertrophy (HP:0001670)1.76882656
132Purpura (HP:0000979)1.76796849
133Recurrent fungal infections (HP:0002841)1.75954469
134Selective tooth agenesis (HP:0001592)1.75601272
135Dysautonomia (HP:0002459)1.73272920
136Recurrent skin infections (HP:0001581)1.72815546
137Osteomalacia (HP:0002749)1.72441769
138Myositis (HP:0100614)1.72104384
139Poikiloderma (HP:0001029)1.71818620
140Recurrent bronchitis (HP:0002837)1.71793195
141Cervical subluxation (HP:0003308)1.71043255
142Squamous cell carcinoma (HP:0002860)1.70727586
143Paraparesis (HP:0002385)1.70055183
144Colitis (HP:0002583)1.70012148
145Abnormality of the intrinsic pathway (HP:0010989)1.70000029
146Progressive external ophthalmoplegia (HP:0000590)1.69321673
147Abdominal distention (HP:0003270)1.68028971
148Microretrognathia (HP:0000308)1.65273504
149Bone marrow hypocellularity (HP:0005528)1.64505171
150Recurrent abscess formation (HP:0002722)1.64321073
151Exocrine pancreatic insufficiency (HP:0001738)1.64123001
152Unilateral renal agenesis (HP:0000122)1.63763415
153Growth hormone excess (HP:0000845)1.63399082
154Systemic lupus erythematosus (HP:0002725)1.63014316
155Spontaneous hematomas (HP:0007420)1.62334183
156Leukopenia (HP:0001882)1.62323985
157Gastrointestinal inflammation (HP:0004386)1.62301729
158Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.62038301
159Gastrointestinal stroma tumor (HP:0100723)1.61871651
160Cardiomegaly (HP:0001640)1.61824531
161Prostate neoplasm (HP:0100787)1.61793362
162Personality changes (HP:0000751)1.61290450
163Abnormality of T cells (HP:0002843)1.61091752
164Myopathic facies (HP:0002058)1.60665754
165Nuclear cataract (HP:0100018)1.60104123
166Death in childhood (HP:0003819)1.59889486
167Papilledema (HP:0001085)1.59384057
168Patellar dislocation (HP:0002999)1.58452693
169Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.58153971
170Abnormal large intestine physiology (HP:0012700)1.58071782
171Abnormality of the fingertips (HP:0001211)1.57918110
172Duplicated collecting system (HP:0000081)1.56532555
173Bulbar palsy (HP:0001283)1.56457675
174Deep palmar crease (HP:0006191)1.55637371
175Neoplasm of head and neck (HP:0012288)1.55489953
176Esophageal neoplasm (HP:0100751)1.55489953
177Stridor (HP:0010307)1.55016031

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PASK4.72422763
2SMG14.30531656
3FLT33.90221329
4INSRR3.64627494
5ERN13.36327794
6MAPK152.87000288
7VRK22.77585735
8CDK122.55823760
9SCYL22.43786703
10TAOK32.41867765
11ICK2.36477328
12HIPK22.29093960
13PKN22.17589945
14PRPF4B2.13249667
15EEF2K1.98359792
16BRSK21.89563201
17MAP4K11.89150348
18TRIB31.83497770
19ZAP701.80151575
20BTK1.69280938
21KIT1.66281124
22NME21.65955384
23JAK31.62311424
24TGFBR11.55311239
25EIF2AK31.53710912
26BCKDK1.52739444
27TAOK21.52009383
28MAP2K31.51540032
29CAMK1D1.43990391
30CHEK21.37454831
31PIM21.35877899
32TEC1.33450769
33WEE11.32926033
34TESK21.32614613
35DYRK31.27990764
36TAF11.27678487
37MAP3K141.25418624
38IRAK21.20912520
39NEK21.19386369
40RPS6KA41.18521145
41RPS6KB21.18500285
42CAMKK21.17740649
43ACVR1B1.17083779
44MAPKAPK31.16732224
45TBK11.12655293
46TYK21.08449548
47STK161.06785678
48TGFBR21.03950860
49CDC71.01579521
50MAP3K21.01572099
51MATK1.01363826
52BLK0.99757294
53MAP3K130.98364516
54CCNB10.97745574
55LRRK20.97123785
56TAOK10.95747078
57MAP3K10.95096884
58IRAK40.87839168
59IKBKB0.87559730
60MTOR0.87122897
61NLK0.85308679
62AURKA0.84931303
63PIK3CG0.83490251
64DYRK1B0.82362506
65MAP2K20.82117241
66MAP3K30.81263926
67VRK10.80755097
68BRSK10.80486810
69MAP3K100.79928442
70CAMK1G0.79877095
71PTK60.75418301
72SYK0.75240038
73CDK70.75110889
74ATR0.74966617
75EPHA30.72609131
76CHEK10.72467801
77PRKG20.70374266
78MST1R0.67923427
79PBK0.67245473
80PAK40.65394897
81RPS6KA60.64892122
82RPS6KL10.62736244
83RPS6KC10.62736244
84NEK10.62702430
85BRAF0.62527572
86IRAK30.61974774
87CDK80.61954490
88JAK20.60794678
89IRAK10.60413878
90CSF1R0.59884361
91BRD40.59764354
92TESK10.58953735
93MELK0.58563110
94BMX0.57903964
95PDPK10.57364543
96CDK90.56266239
97AURKB0.55673792
98ABL20.55441040
99RIPK10.54467383
100KDR0.54139947
101TTK0.53990703
102SIK10.53242705
103PRKD30.52963216
104PIM10.52303184
105RPS6KA20.51241042
106CHUK0.50967044
107TNK20.50582007
108DAPK10.50331698
109STK100.50166373
110PRKCI0.49831150
111LYN0.49780600
112LCK0.48863674
113TIE10.48033841
114CDC42BPA0.47645210
115CDK40.47553307
116MAP2K60.47157909
117MUSK0.47047105
118ITK0.46923959
119MAPK110.46446260
120FGFR40.46254606
121TTN0.44785658
122AKT20.44445568
123IKBKE0.43628898
124RPS6KA10.43417291
125FRK0.41906774
126PDGFRA0.41633628
127CDK20.41590361
128EPHA20.41134713
129PTK20.40574919
130NME10.40477963
131STK40.40376102
132MAP3K80.39267334
133ARAF0.38932045
134MAPKAPK20.38857623
135TLK10.37887899
136BUB10.37672394
137PLK10.37268222
138MAP3K110.36705373
139RIPK40.36531441
140CDK60.36226208
141MAPK30.36191791
142GRK60.36156959
143NEK90.34497595
144CLK10.33162536
145CDK10.32845805

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049506.22156233
2Protein export_Homo sapiens_hsa030604.44329870
3DNA replication_Homo sapiens_hsa030303.23381298
4Other glycan degradation_Homo sapiens_hsa005112.78017909
5Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.77122520
6N-Glycan biosynthesis_Homo sapiens_hsa005102.64897096
7Mismatch repair_Homo sapiens_hsa034302.49362260
8Glycosaminoglycan degradation_Homo sapiens_hsa005312.29286919
9Cyanoamino acid metabolism_Homo sapiens_hsa004602.23251006
10Ribosome_Homo sapiens_hsa030102.12318709
11Base excision repair_Homo sapiens_hsa034102.00434402
12Lysosome_Homo sapiens_hsa041421.88293831
13Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.85007526
14Folate biosynthesis_Homo sapiens_hsa007901.76480553
15Selenocompound metabolism_Homo sapiens_hsa004501.75613818
16Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.74238403
17Carbohydrate digestion and absorption_Homo sapiens_hsa049731.63027080
18Homologous recombination_Homo sapiens_hsa034401.58237842
19Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.56860076
20Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.56417725
21Antigen processing and presentation_Homo sapiens_hsa046121.51340339
22Galactose metabolism_Homo sapiens_hsa000521.49020534
23Sulfur metabolism_Homo sapiens_hsa009201.45993070
24Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.45956847
25Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.41824749
26Biosynthesis of amino acids_Homo sapiens_hsa012301.36836466
27Pyrimidine metabolism_Homo sapiens_hsa002401.35725475
28Legionellosis_Homo sapiens_hsa051341.34509522
29Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.22253887
30Nucleotide excision repair_Homo sapiens_hsa034201.21904463
31Cell cycle_Homo sapiens_hsa041101.19926693
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.16258403
33Type I diabetes mellitus_Homo sapiens_hsa049401.14056245
34Insulin secretion_Homo sapiens_hsa049111.11097022
35Vitamin B6 metabolism_Homo sapiens_hsa007501.11031811
36Spliceosome_Homo sapiens_hsa030401.08980157
37Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.03777207
382-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.03486924
39RNA degradation_Homo sapiens_hsa030181.01415979
40Vibrio cholerae infection_Homo sapiens_hsa051100.99599184
41Non-small cell lung cancer_Homo sapiens_hsa052230.97857309
42Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.95894549
43Leishmaniasis_Homo sapiens_hsa051400.93862769
44Intestinal immune network for IgA production_Homo sapiens_hsa046720.91910851
45Non-homologous end-joining_Homo sapiens_hsa034500.90962824
46Herpes simplex infection_Homo sapiens_hsa051680.90195118
47Acute myeloid leukemia_Homo sapiens_hsa052210.89088167
48Type II diabetes mellitus_Homo sapiens_hsa049300.86330735
49One carbon pool by folate_Homo sapiens_hsa006700.85628414
50Thyroid cancer_Homo sapiens_hsa052160.85294716
51Insulin resistance_Homo sapiens_hsa049310.83032500
52RNA transport_Homo sapiens_hsa030130.81945439
53mRNA surveillance pathway_Homo sapiens_hsa030150.80773748
54Pancreatic cancer_Homo sapiens_hsa052120.79949587
55Measles_Homo sapiens_hsa051620.79807766
56Fructose and mannose metabolism_Homo sapiens_hsa000510.77497372
57p53 signaling pathway_Homo sapiens_hsa041150.76651428
58Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.76396148
59ABC transporters_Homo sapiens_hsa020100.75990719
60TNF signaling pathway_Homo sapiens_hsa046680.75191348
61Asthma_Homo sapiens_hsa053100.74749357
62Circadian rhythm_Homo sapiens_hsa047100.71413486
63Carbon metabolism_Homo sapiens_hsa012000.70783042
64Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.69903457
65Prolactin signaling pathway_Homo sapiens_hsa049170.68830623
66Hepatitis C_Homo sapiens_hsa051600.67898625
67Sulfur relay system_Homo sapiens_hsa041220.67082779
68SNARE interactions in vesicular transport_Homo sapiens_hsa041300.66833270
69Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.66521920
70Hematopoietic cell lineage_Homo sapiens_hsa046400.66325821
71Fanconi anemia pathway_Homo sapiens_hsa034600.66293919
72Systemic lupus erythematosus_Homo sapiens_hsa053220.65923570
73Transcriptional misregulation in cancer_Homo sapiens_hsa052020.65479418
74Purine metabolism_Homo sapiens_hsa002300.64731534
75Allograft rejection_Homo sapiens_hsa053300.63909922
76VEGF signaling pathway_Homo sapiens_hsa043700.63619204
77Rheumatoid arthritis_Homo sapiens_hsa053230.63248157
78Viral carcinogenesis_Homo sapiens_hsa052030.62404527
79Pentose phosphate pathway_Homo sapiens_hsa000300.62393933
80Chronic myeloid leukemia_Homo sapiens_hsa052200.60395635
81Longevity regulating pathway - mammal_Homo sapiens_hsa042110.59146335
82Hepatitis B_Homo sapiens_hsa051610.56509838
83Jak-STAT signaling pathway_Homo sapiens_hsa046300.56197092
84Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.55702122
85Prion diseases_Homo sapiens_hsa050200.54567338
86Influenza A_Homo sapiens_hsa051640.54555850
87Renin-angiotensin system_Homo sapiens_hsa046140.54111197
88Toll-like receptor signaling pathway_Homo sapiens_hsa046200.53966638
89Regulation of autophagy_Homo sapiens_hsa041400.53173432
90NOD-like receptor signaling pathway_Homo sapiens_hsa046210.52874444
91RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.52231662
92Osteoclast differentiation_Homo sapiens_hsa043800.51626268
93NF-kappa B signaling pathway_Homo sapiens_hsa040640.51025259
94Glutathione metabolism_Homo sapiens_hsa004800.50335983
95Staphylococcus aureus infection_Homo sapiens_hsa051500.48864197
96Apoptosis_Homo sapiens_hsa042100.48398388
97Adipocytokine signaling pathway_Homo sapiens_hsa049200.45398055
98RNA polymerase_Homo sapiens_hsa030200.45323316
99Pertussis_Homo sapiens_hsa051330.45317913
100B cell receptor signaling pathway_Homo sapiens_hsa046620.44831445
101Toxoplasmosis_Homo sapiens_hsa051450.44547780
102Drug metabolism - other enzymes_Homo sapiens_hsa009830.42750440
103Central carbon metabolism in cancer_Homo sapiens_hsa052300.42538496
104Salmonella infection_Homo sapiens_hsa051320.42458162
105Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.42134645
106Pancreatic secretion_Homo sapiens_hsa049720.41692694
107HTLV-I infection_Homo sapiens_hsa051660.40866288
108Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.40302832
109Epstein-Barr virus infection_Homo sapiens_hsa051690.40176321
110Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.40122556
111Platelet activation_Homo sapiens_hsa046110.39582007
112Glucagon signaling pathway_Homo sapiens_hsa049220.39453957
113Sphingolipid metabolism_Homo sapiens_hsa006000.38450051
114Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.38195217
115Starch and sucrose metabolism_Homo sapiens_hsa005000.38023500
116Autoimmune thyroid disease_Homo sapiens_hsa053200.37525255
117Lysine degradation_Homo sapiens_hsa003100.37462475
118Graft-versus-host disease_Homo sapiens_hsa053320.36637797
119Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.36353686
120Shigellosis_Homo sapiens_hsa051310.35859987
121Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.35806184
122Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.33294687
123Primary immunodeficiency_Homo sapiens_hsa053400.32750790
124Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.30694692
125Notch signaling pathway_Homo sapiens_hsa043300.30504327
126Tuberculosis_Homo sapiens_hsa051520.29451695
127Insulin signaling pathway_Homo sapiens_hsa049100.27298209
128Neurotrophin signaling pathway_Homo sapiens_hsa047220.26594081
129Proteasome_Homo sapiens_hsa030500.26582538
130mTOR signaling pathway_Homo sapiens_hsa041500.26525733
131Bladder cancer_Homo sapiens_hsa052190.25590799
132Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.25287996

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