CLNK

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: MIST is a member of the SLP76 family of adaptors (see LCP2, MIM 601603; BLNK, MIM 604515). MIST plays a role in the regulation of immunoreceptor signaling, including PLC-gamma (PLCG1; MIM 172420)-mediated B cell antigen receptor (BCR) signaling and FC-epsilon R1 (see FCER1A, MIM 147140)-mediated mast cell degranulation (Cao et al., 1999 [PubMed 10562326]; Goitsuka et al., 2000, 2001 [PubMed 10744659] [PubMed 11463797]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of T cell mediated cytotoxicity (GO:0001914)6.18002047
2positive regulation of T cell mediated cytotoxicity (GO:0001916)6.04477044
3antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.87627476
4interferon-gamma production (GO:0032609)5.62943942
5ribosomal small subunit assembly (GO:0000028)5.29561209
6fucose catabolic process (GO:0019317)5.27941767
7L-fucose metabolic process (GO:0042354)5.27941767
8L-fucose catabolic process (GO:0042355)5.27941767
9platelet dense granule organization (GO:0060155)4.80986951
10behavioral response to nicotine (GO:0035095)4.69627063
11cellular response to interleukin-15 (GO:0071350)4.60259902
12antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.56350068
13antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.56350068
14antigen processing and presentation via MHC class Ib (GO:0002475)4.46478944
15response to interleukin-15 (GO:0070672)4.37970107
16positive regulation of defense response to virus by host (GO:0002230)4.28831747
17negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.20550317
18negative regulation of cell killing (GO:0031342)4.20550317
19DNA deamination (GO:0045006)4.19037871
20positive regulation of B cell differentiation (GO:0045579)4.11491742
21mitochondrial respiratory chain complex I assembly (GO:0032981)4.08887572
22NADH dehydrogenase complex assembly (GO:0010257)4.08887572
23mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.08887572
24antigen processing and presentation of endogenous antigen (GO:0019883)3.97389103
25tolerance induction (GO:0002507)3.96288398
26mature B cell differentiation involved in immune response (GO:0002313)3.94041597
27mast cell activation (GO:0045576)3.90275595
28mucosal-associated lymphoid tissue development (GO:0048537)3.87713758
29Peyers patch development (GO:0048541)3.87713758
30lymph node development (GO:0048535)3.87688992
31regulation of memory T cell differentiation (GO:0043380)3.84562608
32regulation of leukocyte mediated cytotoxicity (GO:0001910)3.81897613
33tyrosine phosphorylation of STAT protein (GO:0007260)3.78956163
34neural tube formation (GO:0001841)3.76344341
35positive regulation of granulocyte differentiation (GO:0030854)3.74135022
36T-helper cell differentiation (GO:0042093)3.72974726
37CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.72974726
38protein complex biogenesis (GO:0070271)3.72639484
39regulation of B cell differentiation (GO:0045577)3.72254198
40response to pheromone (GO:0019236)3.71038324
41piRNA metabolic process (GO:0034587)3.70775852
42indolalkylamine metabolic process (GO:0006586)3.70280149
43lymphoid progenitor cell differentiation (GO:0002320)3.69730042
44thalamus development (GO:0021794)3.66772490
45pinocytosis (GO:0006907)3.64646018
46positive regulation of gamma-delta T cell activation (GO:0046645)3.59815689
47definitive hemopoiesis (GO:0060216)3.59466177
48mast cell activation involved in immune response (GO:0002279)3.57111355
49mast cell degranulation (GO:0043303)3.57111355
50water-soluble vitamin biosynthetic process (GO:0042364)3.56170529
51tryptophan catabolic process (GO:0006569)3.55140938
52indole-containing compound catabolic process (GO:0042436)3.55140938
53indolalkylamine catabolic process (GO:0046218)3.55140938
54positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.55034974
55megakaryocyte development (GO:0035855)3.52861905
56response to interferon-beta (GO:0035456)3.50613340
57centriole replication (GO:0007099)3.47543770
58epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.46465983
59regulation of cell killing (GO:0031341)3.45377636
60viral transcription (GO:0019083)3.44519271
61positive regulation of macrophage differentiation (GO:0045651)3.39849898
62mitochondrial respiratory chain complex assembly (GO:0033108)3.38995820
63regulation of gamma-delta T cell differentiation (GO:0045586)3.38942269
64regulation of activation of Janus kinase activity (GO:0010533)3.35085027
65thrombin receptor signaling pathway (GO:0070493)3.33698241
66positive regulation of T-helper 1 type immune response (GO:0002827)3.30687703
67leukocyte aggregation (GO:0070486)3.29684143
68tryptophan metabolic process (GO:0006568)3.29409518
69kynurenine metabolic process (GO:0070189)3.27585494
70alpha-beta T cell differentiation involved in immune response (GO:0002293)3.27535586
71alpha-beta T cell activation involved in immune response (GO:0002287)3.27535586
72T cell differentiation involved in immune response (GO:0002292)3.27535586
73positive regulation of interleukin-17 production (GO:0032740)3.25535662
74detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.25422681
75secretory granule organization (GO:0033363)3.24920272
76negative regulation of phagocytosis (GO:0050765)3.24788164
77regulation of B cell receptor signaling pathway (GO:0050855)3.23898651
78regulation of gamma-delta T cell activation (GO:0046643)3.21580216
79CD4-positive, alpha-beta T cell differentiation (GO:0043367)3.20964205
80response to protozoan (GO:0001562)3.18918835
81positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.18241018
82neuron fate determination (GO:0048664)3.17815747
83defense response to protozoan (GO:0042832)3.16531535
84translational termination (GO:0006415)3.13328102
85Arp2/3 complex-mediated actin nucleation (GO:0034314)3.12506216
86somite development (GO:0061053)3.12248917
87immunoglobulin mediated immune response (GO:0016064)3.11329728
88neuronal action potential (GO:0019228)3.11090989
89polyketide metabolic process (GO:0030638)3.10965846
90doxorubicin metabolic process (GO:0044598)3.10965846
91daunorubicin metabolic process (GO:0044597)3.10965846
92spinal cord motor neuron differentiation (GO:0021522)3.08920038
93positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.08787434
94positive regulation of cell killing (GO:0031343)3.08666003
95regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)3.08495143
96regulation of T cell mediated immunity (GO:0002709)3.07634845
97regulation of T-helper 1 type immune response (GO:0002825)3.03893753
98regulation of natural killer cell activation (GO:0032814)3.01838886
99cellular response to interferon-beta (GO:0035458)3.01650174
100indole-containing compound metabolic process (GO:0042430)3.00796251
101positive regulation of T cell mediated immunity (GO:0002711)2.99673852
102positive regulation of oligodendrocyte differentiation (GO:0048714)2.98645895
103RNA destabilization (GO:0050779)2.98386488
104detection of light stimulus involved in sensory perception (GO:0050962)2.97226572
105detection of light stimulus involved in visual perception (GO:0050908)2.97226572
106pancreas development (GO:0031016)2.96656089
107negative regulation of necroptotic process (GO:0060546)2.94534351
108adenosine metabolic process (GO:0046085)2.92184702
109epithelial cilium movement (GO:0003351)2.91387634
110mature B cell differentiation (GO:0002335)2.91178802
111T cell migration (GO:0072678)2.90039963
112alpha-beta T cell activation (GO:0046631)2.88925597
113alpha-beta T cell differentiation (GO:0046632)2.88068308
114multicellular organism reproduction (GO:0032504)2.87844485
115CD4-positive, alpha-beta T cell activation (GO:0035710)2.87579591
116primary amino compound metabolic process (GO:1901160)2.87168361
117axoneme assembly (GO:0035082)2.86932530
118dopamine transport (GO:0015872)2.85966700
119exocrine pancreas development (GO:0031017)2.85779935
120B cell receptor signaling pathway (GO:0050853)2.85529018
121retina layer formation (GO:0010842)2.84245097
122translational elongation (GO:0006414)2.80563969
123response to muramyl dipeptide (GO:0032495)2.79964835
124regulation of necroptotic process (GO:0060544)2.79413432
125hindbrain development (GO:0030902)2.79071520
126DNA methylation involved in gamete generation (GO:0043046)2.78507515
127kidney morphogenesis (GO:0060993)2.77522299
128T cell differentiation (GO:0030217)2.76808712
129regulation of defense response to virus by host (GO:0050691)2.76738128
130positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.76214960
131regulation of podosome assembly (GO:0071801)2.75349118
132regulation of response to interferon-gamma (GO:0060330)2.74733236
133leukocyte degranulation (GO:0043299)2.74427969
134negative regulation of telomere maintenance (GO:0032205)2.73873373
135regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.73307668
136negative regulation of mast cell activation (GO:0033004)2.73269066
137protein polyglutamylation (GO:0018095)2.73242547
138positive regulation of interferon-gamma production (GO:0032729)2.72405024
139actin nucleation (GO:0045010)2.71640557
140natural killer cell activation (GO:0030101)2.71588889
141T cell homeostasis (GO:0043029)2.71167415
142positive regulation of fatty acid transport (GO:2000193)2.70165138
143sulfation (GO:0051923)2.69760064
144positive regulation of natural killer cell activation (GO:0032816)2.68928347
145telomere maintenance via semi-conservative replication (GO:0032201)2.68905737
146endocrine pancreas development (GO:0031018)2.68610958
147regulation of oligodendrocyte differentiation (GO:0048713)2.67443415
148regulation of granulocyte differentiation (GO:0030852)2.67350868
149myeloid dendritic cell activation (GO:0001773)2.67275369
150positive regulation of megakaryocyte differentiation (GO:0045654)2.66687612
151regulation of T cell receptor signaling pathway (GO:0050856)2.66373801
152negative regulation by host of viral transcription (GO:0043922)2.65920441
153nephron epithelium morphogenesis (GO:0072088)2.65342374
154nephron tubule morphogenesis (GO:0072078)2.65342374
155serotonin metabolic process (GO:0042428)2.63316560
156preassembly of GPI anchor in ER membrane (GO:0016254)2.62410530
157protein localization to cilium (GO:0061512)2.61471454
158sequestering of actin monomers (GO:0042989)2.58899162
159respiratory chain complex IV assembly (GO:0008535)2.58457243
160positive regulation of prostaglandin secretion (GO:0032308)2.57184262
161negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.57179716
162adult feeding behavior (GO:0008343)2.56656761
163regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.54190396
164negative regulation of interleukin-1 beta production (GO:0032691)2.53052883
165reflex (GO:0060004)2.53038169
166sleep (GO:0030431)2.52078373
167reciprocal DNA recombination (GO:0035825)2.50425725
168reciprocal meiotic recombination (GO:0007131)2.50425725
169cellular ketone body metabolic process (GO:0046950)2.49643213
170regulation of rhodopsin mediated signaling pathway (GO:0022400)2.49489941
171GTP biosynthetic process (GO:0006183)2.49086709
172behavioral response to ethanol (GO:0048149)2.49038173
173embryonic epithelial tube formation (GO:0001838)2.48689077
174positive regulation of icosanoid secretion (GO:0032305)2.48092391
175serotonin receptor signaling pathway (GO:0007210)2.47552880
176inner ear receptor stereocilium organization (GO:0060122)2.47391495
177cellular biogenic amine catabolic process (GO:0042402)2.47371940
178amine catabolic process (GO:0009310)2.47371940
179urinary tract smooth muscle contraction (GO:0014848)2.46182429
180G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.44417347
181regulation of action potential (GO:0098900)2.43220314
182ATP synthesis coupled proton transport (GO:0015986)2.41954873
183energy coupled proton transport, down electrochemical gradient (GO:0015985)2.41954873
184rhodopsin mediated signaling pathway (GO:0016056)2.41800374
185positive regulation of triglyceride biosynthetic process (GO:0010867)2.41412261
186pyrimidine nucleobase catabolic process (GO:0006208)2.38724385
187fucosylation (GO:0036065)2.37845281
188limb bud formation (GO:0060174)2.37182987
189regulation of mesoderm development (GO:2000380)2.36727623
190cytidine deamination (GO:0009972)2.36691227
191cytidine metabolic process (GO:0046087)2.36691227
192cytidine catabolic process (GO:0006216)2.36691227
193auditory receptor cell stereocilium organization (GO:0060088)2.36580406
194startle response (GO:0001964)2.36061946
195cilium movement (GO:0003341)2.35949152
196autophagic vacuole fusion (GO:0000046)2.35497148

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.71204127
2SCL_19346495_ChIP-Seq_HPC-7_Human4.64907290
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.51735970
4ZNF274_21170338_ChIP-Seq_K562_Hela4.27392702
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.00302637
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.99886441
7BP1_19119308_ChIP-ChIP_Hs578T_Human3.54678731
8RUNX1_20887958_ChIP-Seq_HPC-7_Mouse3.53164450
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.49513268
10IRF8_22096565_ChIP-ChIP_GC-B_Human3.44691489
11ELF1_17652178_ChIP-ChIP_JURKAT_Human3.16887591
12STAT4_19710469_ChIP-ChIP_TH1__Mouse3.16853994
13SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.14116581
14EGR1_19374776_ChIP-ChIP_THP-1_Human3.13279285
15VDR_22108803_ChIP-Seq_LS180_Human3.09538276
16EZH2_22144423_ChIP-Seq_EOC_Human3.07373598
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.92422429
18SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.87099741
19STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.83897207
20E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.77928920
21MYB_26560356_Chip-Seq_TH2_Human2.76421421
22IRF8_21731497_ChIP-ChIP_J774_Mouse2.74661722
23IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.54947090
24* RUNX_20019798_ChIP-Seq_JUKART_Human2.52826903
25ZFP57_27257070_Chip-Seq_ESCs_Mouse2.48769214
26LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.48635084
27GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.44710426
28FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.43050180
29IGF1R_20145208_ChIP-Seq_DFB_Human2.42043547
30GBX2_23144817_ChIP-Seq_PC3_Human2.41696718
31MYB_21317192_ChIP-Seq_ERMYB_Mouse2.35979630
32TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.31342223
33MYC_22102868_ChIP-Seq_BL_Human2.28682282
34CTBP2_25329375_ChIP-Seq_LNCAP_Human2.24934258
35MYB_26560356_Chip-Seq_TH1_Human2.22853299
36CTBP1_25329375_ChIP-Seq_LNCAP_Human2.21929660
37RUNX1_22412390_ChIP-Seq_EML_Mouse2.19900762
38FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.19268295
39NOTCH1_21737748_ChIP-Seq_TLL_Human2.16799589
40MAF_26560356_Chip-Seq_TH1_Human2.14916153
41* SPI1_23547873_ChIP-Seq_NB4_Human2.13601003
42EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.12383768
43ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.06752226
44POU3F2_20337985_ChIP-ChIP_501MEL_Human2.06402503
45FUS_26573619_Chip-Seq_HEK293_Human2.05616242
46VDR_21846776_ChIP-Seq_THP-1_Human2.02893975
47LMO2_20887958_ChIP-Seq_HPC-7_Mouse2.01918135
48HOXB4_20404135_ChIP-ChIP_EML_Mouse2.00106621
49MEIS1_20887958_ChIP-Seq_HPC-7_Mouse2.00016676
50EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.98755306
51PCGF2_27294783_Chip-Seq_ESCs_Mouse1.94662329
52* P300_19829295_ChIP-Seq_ESCs_Human1.93363137
53SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.91198572
54IRF8_27001747_Chip-Seq_BMDM_Mouse1.89327332
55EWS_26573619_Chip-Seq_HEK293_Human1.85582318
56VDR_24763502_ChIP-Seq_THP-1_Human1.85580387
57NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.81336496
58SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.78797198
59BMI1_23680149_ChIP-Seq_NPCS_Mouse1.76914341
60ER_23166858_ChIP-Seq_MCF-7_Human1.74967777
61ERG_20887958_ChIP-Seq_HPC-7_Mouse1.71800776
62BRD4_27068464_Chip-Seq_AML-cells_Mouse1.69730326
63UTX_26944678_Chip-Seq_JUKART_Human1.68748475
64NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.65273112
65HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.63897157
66TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.61926728
67POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.61436957
68TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.61436957
69TCF7_22412390_ChIP-Seq_EML_Mouse1.61352483
70GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.57785128
71CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.56710840
72AR_21572438_ChIP-Seq_LNCaP_Human1.56259224
73PCGF2_27294783_Chip-Seq_NPCs_Mouse1.56220923
74CBX2_27304074_Chip-Seq_ESCs_Mouse1.55720192
75FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.54348057
76GATA2_22383799_ChIP-Seq_G1ME_Mouse1.53933155
77CIITA_25753668_ChIP-Seq_RAJI_Human1.53285044
78GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.53198493
79MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.51946768
80UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.51725510
81* TP53_22573176_ChIP-Seq_HFKS_Human1.50161829
82* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.49481016
83* CBP_20019798_ChIP-Seq_JUKART_Human1.49481016
84TAF15_26573619_Chip-Seq_HEK293_Human1.48986987
85MYC_18940864_ChIP-ChIP_HL60_Human1.48831792
86E2F4_17652178_ChIP-ChIP_JURKAT_Human1.47966914
87MYC_18555785_ChIP-Seq_MESCs_Mouse1.47030082
88VDR_23849224_ChIP-Seq_CD4+_Human1.45924557
89AR_25329375_ChIP-Seq_VCAP_Human1.45624773
90EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.42501542
91GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.41573784
92* GATA3_27048872_Chip-Seq_THYMUS_Human1.39053868
93BCAT_22108803_ChIP-Seq_LS180_Human1.37679049
94GATA1_22383799_ChIP-Seq_G1ME_Mouse1.36842353
95MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.35684732
96NR3C1_21868756_ChIP-Seq_MCF10A_Human1.33931803
97* FOXA1_25329375_ChIP-Seq_VCAP_Human1.33626658
98* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.33626658
99EST1_17652178_ChIP-ChIP_JURKAT_Human1.32631341
100TCF4_23295773_ChIP-Seq_U87_Human1.31758872
101REST_21632747_ChIP-Seq_MESCs_Mouse1.31504211
102TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.30870154
103SOX2_19829295_ChIP-Seq_ESCs_Human1.30780592
104NANOG_19829295_ChIP-Seq_ESCs_Human1.30780592
105SUZ12_27294783_Chip-Seq_NPCs_Mouse1.30774270
106NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.28834640
107* STAT3_23295773_ChIP-Seq_U87_Human1.28746775
108* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.28445104
109NFE2_27457419_Chip-Seq_LIVER_Mouse1.27388068
110* PIAS1_25552417_ChIP-Seq_VCAP_Human1.27376489
111AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.25487353
112E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.24767742
113TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24481610
114RNF2_27304074_Chip-Seq_NSC_Mouse1.24389133
115NCOR_22424771_ChIP-Seq_293T_Human1.23752780
116GATA1_19941827_ChIP-Seq_MEL_Mouse1.22547781
117FOXP3_21729870_ChIP-Seq_TREG_Human1.22283443
118IKZF1_21737484_ChIP-ChIP_HCT116_Human1.21481325
119RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.21332629
120MAF_26560356_Chip-Seq_TH2_Human1.21095541
121SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20777566
122MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.20426531
123GATA3_26560356_Chip-Seq_TH2_Human1.20190233
124GATA3_21878914_ChIP-Seq_MCF-7_Human1.19455843
125EED_16625203_ChIP-ChIP_MESCs_Mouse1.18116278
126PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.17901952
127EZH2_27294783_Chip-Seq_NPCs_Mouse1.17736304
128PU_27001747_Chip-Seq_BMDM_Mouse1.16347282
129ETS1_22383799_ChIP-Seq_G1ME_Mouse1.15840794
130* SPI1_23127762_ChIP-Seq_K562_Human1.13922652
131* PRDM14_20953172_ChIP-Seq_ESCs_Human1.13461383
132FOXA1_21572438_ChIP-Seq_LNCaP_Human1.13033593
133* AR_20517297_ChIP-Seq_VCAP_Human1.12849957
134FLI1_21867929_ChIP-Seq_TH2_Mouse1.11977001
135RUNX2_22187159_ChIP-Seq_PCA_Human1.11909587
136FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.11720739
137GATA1_22025678_ChIP-Seq_K562_Human1.11567955
138ETV2_25802403_ChIP-Seq_MESCs_Mouse1.11492415
139PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.11289079
140SMAD4_21799915_ChIP-Seq_A2780_Human1.11162366
141KLF5_20875108_ChIP-Seq_MESCs_Mouse1.10785678
142IRF1_19129219_ChIP-ChIP_H3396_Human1.10023389
143* SMAD3_21741376_ChIP-Seq_EPCs_Human1.10019785
144* TCF4_22108803_ChIP-Seq_LS180_Human1.09016764
145SMAD4_21741376_ChIP-Seq_EPCs_Human1.08832804
146HOXB7_26014856_ChIP-Seq_BT474_Human1.07980202
147JARID2_20064375_ChIP-Seq_MESCs_Mouse1.07626357
148PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.07332809
149POU5F1_16153702_ChIP-ChIP_HESCs_Human1.05569305
150MYC_18358816_ChIP-ChIP_MESCs_Mouse1.04682430
151NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.02345536
152MYC_19079543_ChIP-ChIP_MESCs_Mouse1.01241547
153FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.99170303
154PU.1_20513432_ChIP-Seq_Bcells_Mouse0.98708159
155CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.98045893
156CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.97854978
157ELK1_19687146_ChIP-ChIP_HELA_Human0.97705439
158KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.96995451
159MYC_19829295_ChIP-Seq_ESCs_Human0.96951893
160CRX_20693478_ChIP-Seq_RETINA_Mouse0.96174552
161TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.95983887
162* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.95385734
163XRN2_22483619_ChIP-Seq_HELA_Human0.95258071
164EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.94327029
165GABP_17652178_ChIP-ChIP_JURKAT_Human0.94158769
166EGR1_23403033_ChIP-Seq_LIVER_Mouse0.94068009
167* NANOG_18555785_Chip-Seq_ESCs_Mouse0.93733808
168SALL1_21062744_ChIP-ChIP_HESCs_Human0.93720950
169PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93556123
170RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.91593747
171HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.91449659
172SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.89105177
173MYC_19030024_ChIP-ChIP_MESCs_Mouse0.85829662
174SRF_21415370_ChIP-Seq_HL-1_Mouse0.80994176
175FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80895003
176RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78222555
177PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.78087952
178E2F1_21310950_ChIP-Seq_MCF-7_Human0.77709920
179FLI1_27457419_Chip-Seq_LIVER_Mouse0.77341377
180* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.76371764
181CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.75561757
182NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.75080916
183JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.74885296
184NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.74884937
185STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.73695741
186HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.71892602

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.31670310
2MP0005671_abnormal_response_to3.82811358
3MP0002396_abnormal_hematopoietic_system3.47733506
4MP0009785_altered_susceptibility_to3.46952520
5MP0000685_abnormal_immune_system3.32507124
6MP0003724_increased_susceptibility_to2.92608248
7MP0002102_abnormal_ear_morphology2.89254465
8MP0003763_abnormal_thymus_physiology2.86624400
9MP0003195_calcinosis2.81993169
10MP0001800_abnormal_humoral_immune2.79590745
11MP0005387_immune_system_phenotype2.78669365
12MP0001790_abnormal_immune_system2.78669365
13MP0003866_abnormal_defecation2.72187399
14MP0000569_abnormal_digit_pigmentation2.70327116
15MP0005000_abnormal_immune_tolerance2.69992274
16* MP0002723_abnormal_immune_serum2.58491895
17* MP0001819_abnormal_immune_cell2.56175016
18* MP0002420_abnormal_adaptive_immunity2.55476682
19MP0002398_abnormal_bone_marrow2.54466661
20MP0005025_abnormal_response_to2.50230257
21MP0002452_abnormal_antigen_presenting2.42188043
22MP0004147_increased_porphyrin_level2.38974489
23MP0001853_heart_inflammation2.37881193
24MP0005075_abnormal_melanosome_morpholog2.32203944
25MP0005084_abnormal_gallbladder_morpholo2.31716581
26MP0002405_respiratory_system_inflammati2.22014021
27MP0005551_abnormal_eye_electrophysiolog2.21441865
28* MP0000716_abnormal_immune_system2.14980962
29MP0002166_altered_tumor_susceptibility2.14070276
30MP0004808_abnormal_hematopoietic_stem2.13719344
31MP0005174_abnormal_tail_pigmentation2.11577361
32MP0002722_abnormal_immune_system2.08851162
33MP0001968_abnormal_touch/_nociception2.06928847
34MP0005464_abnormal_platelet_physiology2.05585322
35MP0000689_abnormal_spleen_morphology2.05351606
36MP0004510_myositis2.03588475
37MP0010155_abnormal_intestine_physiology2.03579866
38MP0001529_abnormal_vocalization2.00459846
39MP0002419_abnormal_innate_immunity2.00131053
40MP0002653_abnormal_ependyma_morphology1.98357804
41MP0000465_gastrointestinal_hemorrhage1.94395620
42MP0002148_abnormal_hypersensitivity_rea1.91298558
43MP0005397_hematopoietic_system_phenotyp1.88171290
44MP0001545_abnormal_hematopoietic_system1.88171290
45* MP0002429_abnormal_blood_cell1.85481005
46MP0005645_abnormal_hypothalamus_physiol1.84252826
47MP0003646_muscle_fatigue1.84089476
48MP0006072_abnormal_retinal_apoptosis1.83345586
49MP0005646_abnormal_pituitary_gland1.82691093
50MP0000703_abnormal_thymus_morphology1.79846922
51MP0003436_decreased_susceptibility_to1.76319490
52MP0008875_abnormal_xenobiotic_pharmacok1.75948258
53MP0002006_tumorigenesis1.75565389
54MP0004142_abnormal_muscle_tone1.74423343
55MP0002876_abnormal_thyroid_physiology1.73830630
56MP0000490_abnormal_crypts_of1.72883498
57MP0004043_abnormal_pH_regulation1.72148837
58MP0009333_abnormal_splenocyte_physiolog1.70637408
59MP0002138_abnormal_hepatobiliary_system1.70477981
60MP0009745_abnormal_behavioral_response1.69493699
61MP0002736_abnormal_nociception_after1.69279060
62MP0002837_dystrophic_cardiac_calcinosis1.66582266
63MP0002877_abnormal_melanocyte_morpholog1.64239907
64MP0001873_stomach_inflammation1.63695941
65MP0001845_abnormal_inflammatory_respons1.59907120
66MP0003880_abnormal_central_pattern1.57834593
67MP0003136_yellow_coat_color1.55013595
68MP0001501_abnormal_sleep_pattern1.52397430
69MP0000631_abnormal_neuroendocrine_gland1.48849540
70MP0006276_abnormal_autonomic_nervous1.48547678
71MP0006082_CNS_inflammation1.46996782
72MP0002733_abnormal_thermal_nociception1.43077394
73MP0003283_abnormal_digestive_organ1.42947990
74MP0004947_skin_inflammation1.40391945
75MP0002735_abnormal_chemical_nociception1.39079768
76MP0004742_abnormal_vestibular_system1.38471337
77MP0005253_abnormal_eye_physiology1.38070789
78MP0002938_white_spotting1.36462114
79MP0002638_abnormal_pupillary_reflex1.35900609
80MP0001905_abnormal_dopamine_level1.35081525
81MP0002272_abnormal_nervous_system1.33099833
82MP0004885_abnormal_endolymph1.32543482
83MP0001348_abnormal_lacrimal_gland1.31403410
84MP0008469_abnormal_protein_level1.31121376
85MP0000343_altered_response_to1.31085338
86MP0002277_abnormal_respiratory_mucosa1.29516262
87MP0002095_abnormal_skin_pigmentation1.28463737
88MP0003787_abnormal_imprinting1.26351926
89MP0009765_abnormal_xenobiotic_induced1.26247459
90MP0003638_abnormal_response/metabolism_1.25990990
91MP0009046_muscle_twitch1.24610754
92MP0008007_abnormal_cellular_replicative1.23236659
93MP0001970_abnormal_pain_threshold1.20760450
94MP0005386_behavior/neurological_phenoty1.20133979
95MP0004924_abnormal_behavior1.20133979
96MP0001486_abnormal_startle_reflex1.18479192
97MP0000383_abnormal_hair_follicle1.14828891
98MP0005389_reproductive_system_phenotype1.14110975
99MP0002572_abnormal_emotion/affect_behav1.13559289
100MP0002933_joint_inflammation1.11600848
101MP0010234_abnormal_vibrissa_follicle1.11082837
102MP0001188_hyperpigmentation1.10657793
103MP0010307_abnormal_tumor_latency1.10580596
104MP0002067_abnormal_sensory_capabilities1.10551199
105MP0004133_heterotaxia1.09878096
106MP0000026_abnormal_inner_ear1.09532236
107MP0003300_gastrointestinal_ulcer1.07712345
108MP0002557_abnormal_social/conspecific_i1.07601519
109MP0002163_abnormal_gland_morphology1.06886070
110MP0005410_abnormal_fertilization1.06855141
111MP0000858_altered_metastatic_potential1.06829059
112MP0004145_abnormal_muscle_electrophysio1.01495075
113MP0002234_abnormal_pharynx_morphology1.00825838
114MP0002064_seizures0.99918192
115MP0008057_abnormal_DNA_replication0.99846480
116MP0006292_abnormal_olfactory_placode0.99760553
117MP0001919_abnormal_reproductive_system0.99054246
118MP0005379_endocrine/exocrine_gland_phen0.95866394
119MP0003938_abnormal_ear_development0.95189280
120MP0002693_abnormal_pancreas_physiology0.94801828
121MP0005310_abnormal_salivary_gland0.94468368
122MP0000372_irregular_coat_pigmentation0.94245843
123MP0002160_abnormal_reproductive_system0.93766537
124MP0000427_abnormal_hair_cycle0.93609143
125MP0005195_abnormal_posterior_eye0.93024955
126MP0002019_abnormal_tumor_incidence0.92549530
127MP0006054_spinal_hemorrhage0.91791547
128MP0001664_abnormal_digestion0.91712345
129MP0010094_abnormal_chromosome_stability0.89265320
130MP0005377_hearing/vestibular/ear_phenot0.87673860
131MP0003878_abnormal_ear_physiology0.87673860
132MP0002184_abnormal_innervation0.87496621
133MP0001663_abnormal_digestive_system0.87014095
134MP0005220_abnormal_exocrine_pancreas0.86648695
135MP0003252_abnormal_bile_duct0.86560725
136MP0008995_early_reproductive_senescence0.86157387
137MP0001485_abnormal_pinna_reflex0.85959306
138MP0009763_increased_sensitivity_to0.85938758
139MP0003186_abnormal_redox_activity0.85902537
140MP0009764_decreased_sensitivity_to0.85796099
141MP0004782_abnormal_surfactant_physiolog0.85293412
142MP0001851_eye_inflammation0.84793279
143MP0002928_abnormal_bile_duct0.84527526
144MP0003635_abnormal_synaptic_transmissio0.82961215
145MP0003718_maternal_effect0.82922792
146MP0002752_abnormal_somatic_nervous0.82755450
147MP0003698_abnormal_male_reproductive0.81350183
148MP0001984_abnormal_olfaction0.80619425
149MP0005409_darkened_coat_color0.80279190
150MP0003011_delayed_dark_adaptation0.79680457
151MP0000015_abnormal_ear_pigmentation0.79584726
152MP0003448_altered_tumor_morphology0.78487500
153MP0008058_abnormal_DNA_repair0.77694191
154MP0000477_abnormal_intestine_morphology0.77027651
155MP0000313_abnormal_cell_death0.76276640
156MP0001324_abnormal_eye_pigmentation0.76172674
157MP0002063_abnormal_learning/memory/cond0.75991147
158MP0003786_premature_aging0.74187770
159MP0001286_abnormal_eye_development0.72086188
160MP0005167_abnormal_blood-brain_barrier0.71298972
161MP0003077_abnormal_cell_cycle0.70766493
162MP0005423_abnormal_somatic_nervous0.70545060
163MP0001963_abnormal_hearing_physiology0.70156179
164MP0000778_abnormal_nervous_system0.70024911
165MP0001533_abnormal_skeleton_physiology0.69841013
166MP0008877_abnormal_DNA_methylation0.69637139
167MP0003303_peritoneal_inflammation0.69061666
168MP0009278_abnormal_bone_marrow0.68083909
169MP0000371_diluted_coat_color0.66538666
170MP0003943_abnormal_hepatobiliary_system0.63362091
171MP0009379_abnormal_foot_pigmentation0.61228222
172MP0003172_abnormal_lysosome_physiology0.60365175
173MP0001881_abnormal_mammary_gland0.60164198
174MP0008873_increased_physiological_sensi0.56843952
175MP0000249_abnormal_blood_vessel0.55367612
176MP0003075_altered_response_to0.54875562
177MP0001502_abnormal_circadian_rhythm0.53748796
178MP0001986_abnormal_taste_sensitivity0.52837522
179MP0008872_abnormal_physiological_respon0.52015918
180MP0005166_decreased_susceptibility_to0.51636659

Predicted human phenotypes

RankGene SetZ-score
1Myositis (HP:0100614)6.89352356
2Retrobulbar optic neuritis (HP:0100654)6.59068087
3Optic neuritis (HP:0100653)6.59068087
4Orchitis (HP:0100796)6.22543998
5IgM deficiency (HP:0002850)5.85154908
6Keratoconjunctivitis sicca (HP:0001097)4.65303836
7Pancreatic cysts (HP:0001737)4.64447349
8Type II lissencephaly (HP:0007260)4.56539360
9Abnormality of cochlea (HP:0000375)4.47856214
10Cerebellar dysplasia (HP:0007033)4.43737313
11Chronic otitis media (HP:0000389)4.35756502
12Elevated erythrocyte sedimentation rate (HP:0003565)4.32703202
13Aplastic anemia (HP:0001915)4.28173608
14Keratoconjunctivitis (HP:0001096)4.22391134
15Congenital stationary night blindness (HP:0007642)4.02608816
16True hermaphroditism (HP:0010459)3.89344117
17Nephronophthisis (HP:0000090)3.87105466
18Abnormality of midbrain morphology (HP:0002418)3.75848247
19Molar tooth sign on MRI (HP:0002419)3.75848247
20Thrombocytosis (HP:0001894)3.67044166
21Pancreatic fibrosis (HP:0100732)3.63842856
22Vasculitis (HP:0002633)3.47861767
23Increased density of long bones (HP:0006392)3.47578761
24Thyroiditis (HP:0100646)3.44819139
25Encephalitis (HP:0002383)3.42737635
26Hemoptysis (HP:0002105)3.38891869
27Petechiae (HP:0000967)3.34518397
28Meningitis (HP:0001287)3.34206562
29Arterial thrombosis (HP:0004420)3.33647159
30Recurrent bronchitis (HP:0002837)3.26775006
31Abnormality of the renal medulla (HP:0100957)3.22840106
32Pulmonary infiltrates (HP:0002113)3.17030601
33Morphological abnormality of the inner ear (HP:0011390)3.13029104
34Abnormality of T cell physiology (HP:0011840)3.12935506
35IgG deficiency (HP:0004315)3.09980998
36Abnormality of the renal cortex (HP:0011035)3.05274014
37Severe combined immunodeficiency (HP:0004430)3.02882227
38Abnormality of T cells (HP:0002843)2.99016664
39Medial flaring of the eyebrow (HP:0010747)2.97417112
40Muscle fiber atrophy (HP:0100295)2.94531016
41Prolonged bleeding time (HP:0003010)2.92471478
42Panhypogammaglobulinemia (HP:0003139)2.90992935
43Abnormality of the pons (HP:0007361)2.89478352
44Optic nerve hypoplasia (HP:0000609)2.80626057
45Attenuation of retinal blood vessels (HP:0007843)2.78972481
46Recurrent abscess formation (HP:0002722)2.76831215
47Pulmonary fibrosis (HP:0002206)2.73737968
48Lymphoma (HP:0002665)2.72888151
49Chronic diarrhea (HP:0002028)2.72559955
50Tubular atrophy (HP:0000092)2.72182696
51Abnormal rod and cone electroretinograms (HP:0008323)2.71317869
52Vertigo (HP:0002321)2.70333918
53Abnormality of alanine metabolism (HP:0010916)2.68194678
54Hyperalaninemia (HP:0003348)2.68194678
55Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.68194678
56Hypoplasia of the pons (HP:0012110)2.68063349
57Abnormality of the pleura (HP:0002103)2.67389057
58Abolished electroretinogram (ERG) (HP:0000550)2.63315918
59Lissencephaly (HP:0001339)2.62258419
60Gastrointestinal stroma tumor (HP:0100723)2.62128316
61Cystic liver disease (HP:0006706)2.59365752
62Abnormality of B cell number (HP:0010975)2.56457531
63B lymphocytopenia (HP:0010976)2.56457531
64Recurrent bacterial skin infections (HP:0005406)2.55946427
65Pendular nystagmus (HP:0012043)2.52418922
66Recurrent fungal infections (HP:0002841)2.51909218
67Dynein arm defect of respiratory motile cilia (HP:0012255)2.51485603
68Absent/shortened dynein arms (HP:0200106)2.51485603
69Impaired platelet aggregation (HP:0003540)2.51268989
70Abnormal platelet function (HP:0011869)2.51268989
71Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.51240076
72Type 2 muscle fiber atrophy (HP:0003554)2.51089783
73Combined immunodeficiency (HP:0005387)2.49762485
74Keratoconus (HP:0000563)2.49350351
75Increased corneal curvature (HP:0100692)2.49350351
76IgA deficiency (HP:0002720)2.48441622
77Abnormality of the prostate (HP:0008775)2.44819039
78Reticulocytopenia (HP:0001896)2.43372223
79Hyperventilation (HP:0002883)2.42734763
80Gangrene (HP:0100758)2.41711308
81Lymphopenia (HP:0001888)2.38958645
82Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.38783587
83Abnormal drinking behavior (HP:0030082)2.38370464
84Polydipsia (HP:0001959)2.38370464
85Keratitis (HP:0000491)2.36024626
86Recurrent viral infections (HP:0004429)2.35001715
87Renal cortical cysts (HP:0000803)2.34917274
88Glomerulopathy (HP:0100820)2.34718460
89Absent rod-and cone-mediated responses on ERG (HP:0007688)2.34103214
90Severe visual impairment (HP:0001141)2.33283317
91T lymphocytopenia (HP:0005403)2.31175213
92Nasal polyposis (HP:0100582)2.28431842
93Abnormality of macrophages (HP:0004311)2.27825505
94Pulmonary embolism (HP:0002204)2.27214552
95Increased neuronal autofluorescent lipopigment (HP:0002074)2.26875192
96Decreased central vision (HP:0007663)2.26619443
97Spontaneous hematomas (HP:0007420)2.26230581
98Anorexia (HP:0002039)2.23702035
99Abnormal respiratory motile cilium morphology (HP:0005938)2.23429461
100Abnormal respiratory epithelium morphology (HP:0012253)2.23429461
101Congenital sensorineural hearing impairment (HP:0008527)2.23195081
102Abnormal number of erythroid precursors (HP:0012131)2.22179751
103Constricted visual fields (HP:0001133)2.21929015
104Acute lymphatic leukemia (HP:0006721)2.21138893
105Chronic hepatic failure (HP:0100626)2.21084182
106Bronchitis (HP:0012387)2.20924702
107Abnormality of the fingertips (HP:0001211)2.20195106
108Gingival bleeding (HP:0000225)2.19326463
109Pancytopenia (HP:0001876)2.18332085
110Epistaxis (HP:0000421)2.18091811
111Abnormality of cells of the lymphoid lineage (HP:0012140)2.16019291
112Abnormality of eosinophils (HP:0001879)2.14198468
113Poikiloderma (HP:0001029)2.13620519
114Interstitial pulmonary disease (HP:0006530)2.11440421
115Severe muscular hypotonia (HP:0006829)2.10637686
116Chronic obstructive pulmonary disease (HP:0006510)2.09664570
117Obstructive lung disease (HP:0006536)2.09664570
118Decreased circulating renin level (HP:0003351)2.09643599
119Amaurosis fugax (HP:0100576)2.09113585
120Hypothermia (HP:0002045)2.08610078
121Concave nail (HP:0001598)2.08576732
122Polyneuropathy (HP:0001271)2.08435339
123Recurrent sinusitis (HP:0011108)2.08378567
124Acute myeloid leukemia (HP:0004808)2.07894558
125Furrowed tongue (HP:0000221)2.07491363
126Partial agenesis of the corpus callosum (HP:0001338)2.06694756
127Abnormality of T cell number (HP:0011839)2.04879277
128Anencephaly (HP:0002323)2.04643145
129Pallor (HP:0000980)2.04598621
130Abnormality of the nasal mucosa (HP:0000433)2.04583193
131Stomach cancer (HP:0012126)2.04334062
132Congenital, generalized hypertrichosis (HP:0004540)2.04108524
133Tinnitus (HP:0000360)2.04100834
134Gaze-evoked nystagmus (HP:0000640)2.03137013
135Gait imbalance (HP:0002141)2.02965469
136Erythema (HP:0010783)2.02058486
137Bile duct proliferation (HP:0001408)2.01517948
138Abnormal biliary tract physiology (HP:0012439)2.01517948
139Patellar aplasia (HP:0006443)2.01302661
140Inability to walk (HP:0002540)2.01264180
141Broad-based gait (HP:0002136)2.00374977
142Abnormal respiratory motile cilium physiology (HP:0012261)1.99097148
14311 pairs of ribs (HP:0000878)1.98083425
144Sclerocornea (HP:0000647)1.97214721
145Acrocyanosis (HP:0001063)1.97170076
146Aplasia/Hypoplasia of the patella (HP:0006498)1.95826195
147Large for gestational age (HP:0001520)1.94307955
148Polyuria (HP:0000103)1.92763473
149Decreased electroretinogram (ERG) amplitude (HP:0000654)1.92633497
150Stomatitis (HP:0010280)1.92200493
151Joint swelling (HP:0001386)1.92115493
152Clumsiness (HP:0002312)1.92111909
153Hypokalemic alkalosis (HP:0001949)1.92089519
154Hypomagnesemia (HP:0002917)1.92015161
155Mitochondrial inheritance (HP:0001427)1.91565358
156Birth length less than 3rd percentile (HP:0003561)1.90504780
157Recurrent skin infections (HP:0001581)1.90025910
158Albinism (HP:0001022)1.89437928
1593-Methylglutaconic aciduria (HP:0003535)1.89416576
160Male pseudohermaphroditism (HP:0000037)1.89232180
161Congenital hepatic fibrosis (HP:0002612)1.89123793
162Chorioretinal atrophy (HP:0000533)1.89042010
163Oligodactyly (hands) (HP:0001180)1.88957702
164Colon cancer (HP:0003003)1.88795949
165Skin rash (HP:0000988)1.88293770
166Pachygyria (HP:0001302)1.87985520
167Abnormal platelet volume (HP:0011876)1.87959757
168Retinal dysplasia (HP:0007973)1.87865694
169Degeneration of anterior horn cells (HP:0002398)1.87482468
170Abnormality of the anterior horn cell (HP:0006802)1.87482468
171Inflammation of the large intestine (HP:0002037)1.86870338
172Maternal diabetes (HP:0009800)1.86866252
173Eczematoid dermatitis (HP:0000976)1.86062668
174Protruding tongue (HP:0010808)1.85572570
175Calf muscle hypertrophy (HP:0008981)1.85046528
176Gastrointestinal inflammation (HP:0004386)1.84520618
177Abnormality of the pericardium (HP:0001697)1.84356363
178Oral leukoplakia (HP:0002745)1.83982578
179Mediastinal lymphadenopathy (HP:0100721)1.83187148
180Congenital primary aphakia (HP:0007707)1.82953290
181Postaxial foot polydactyly (HP:0001830)1.81666632
182Increased CSF lactate (HP:0002490)1.81492900
183Bony spicule pigmentary retinopathy (HP:0007737)1.81449673
184Adactyly (HP:0009776)1.79697012
185Tachypnea (HP:0002789)1.79057357
186Abnormality of cells of the erythroid lineage (HP:0012130)1.78982225
187Abnormal ciliary motility (HP:0012262)1.78964246
188Methylmalonic acidemia (HP:0002912)1.78513374
189Aplasia/hypoplasia of the uterus (HP:0008684)1.75929471
190Lipid accumulation in hepatocytes (HP:0006561)1.74579619
191Rhinitis (HP:0012384)1.71754129
192Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.71475220
193Progressive microcephaly (HP:0000253)1.71312320
194Aplasia/Hypoplasia of the tongue (HP:0010295)1.70914344
195Decreased subcutaneous fat (HP:0001002)1.70641303
196Bilateral microphthalmos (HP:0007633)1.70001933
197Nephrogenic diabetes insipidus (HP:0009806)1.67824703
198Muscle hypertrophy of the lower extremities (HP:0008968)1.65466997
199Intellectual disability, profound (HP:0002187)1.65222750

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.94918340
2MAP4K14.02254385
3FRK3.81005630
4TAOK33.70809843
5KIT3.69310126
6FLT33.41953625
7BMPR1B3.37608663
8MAP3K122.94316839
9TEC2.62466007
10ZAK2.57023764
11STK242.36708252
12CASK2.35201740
13GRK12.22665051
14IRAK32.21882134
15MAP4K22.21799169
16BTK2.08058098
17EEF2K2.04560364
18ZAP702.03809200
19MATK1.88787418
20CSF1R1.84314204
21STK161.84101672
22PNCK1.83163461
23INSRR1.82923206
24SCYL21.82319339
25TBK11.77375941
26WNK31.73718148
27JAK11.73714728
28FES1.73635355
29SYK1.73523865
30MAPK131.72639908
31MARK11.72583679
32JAK31.66850102
33PIM11.66664545
34IKBKE1.60061700
35PINK11.53025102
36IRAK41.51759278
37TRIM281.49050005
38NLK1.47792186
39SRPK11.44996377
40VRK11.42209535
41ITK1.41823633
42WNK41.35792264
43MAP2K61.35341613
44PIM21.27385102
45NUAK11.26401192
46IKBKB1.25070600
47MAP3K141.22019490
48GRK61.21205019
49PBK1.20343258
50TNIK1.19958222
51PKN21.19187428
52NEK11.16856326
53RPS6KA41.12646925
54MAPKAPK51.11352922
55TSSK61.09062698
56DAPK21.03895384
57TAOK21.03275889
58LYN1.02368005
59ADRBK11.02181491
60LCK0.98560642
61PLK20.96147172
62BLK0.93691844
63TYK20.91327789
64MAP2K30.91203295
65MYLK0.90671960
66DYRK20.89512422
67RPS6KB20.89060276
68TGFBR10.89008084
69HCK0.88891735
70MAP3K40.88488894
71MAPKAPK30.86675283
72CDK30.86295247
73PAK30.85591385
74VRK20.83950237
75CAMKK20.83172647
76OXSR10.82156486
77PKN10.81762734
78LRRK20.79298458
79CHUK0.79148667
80PRKCG0.78913387
81PRKG20.77293067
82PHKG10.76362435
83PHKG20.76362435
84NTRK30.73641192
85SIK30.72490690
86CDK190.71498615
87DAPK10.70848168
88KDR0.70010934
89MAPK150.68932887
90NME20.68856380
91TLK10.68804925
92MKNK10.68450801
93CDC70.65235097
94TESK20.65046259
95FGFR30.63893778
96PRKCE0.63737026
97PLK40.62795388
98MAP2K20.62779415
99EIF2AK10.60263284
100STK38L0.58909495
101STK390.58590458
102BCKDK0.58051702
103TNK20.57140037
104ACVR1B0.56108057
105TAF10.56059439
106NTRK20.53854074
107PLK30.53651370
108PAK40.51534408
109MKNK20.51158050
110MUSK0.49839322
111ERN10.48760517
112TIE10.47695076
113PTK2B0.46824685
114EIF2AK30.45327610
115EPHA40.45205484
116NME10.44946863
117NEK20.44934833
118CDK40.44681457
119TRPM70.44657658
120CSNK1A10.44011978
121ADRBK20.42999868
122STK100.42562079
123TGFBR20.42200612
124CAMK10.42173103
125PRKCI0.41138641
126CDK70.40676696
127MAP2K10.40343844
128RPS6KA50.40271804
129DYRK1A0.39278826
130ILK0.38459604
131FGFR20.37737638
132PRKCQ0.37368813
133PRKACA0.36743939
134CAMK2A0.36648216
135HIPK20.36623297
136PIK3CA0.36183706
137MAPKAPK20.35443758
138SIK20.34509086
139STK40.33758511
140BMPR20.33253781
141CSK0.32956898
142MAP3K70.32482957
143GRK70.31050109
144JAK20.30829348
145MAP2K70.30670047
146PDK10.30477708
147WEE10.30269279
148CCNB10.30088681
149MAP3K50.29935960
150CDK60.29715215
151CSNK1G20.29667563
152RPS6KA60.29481236
153MAPK40.29429371
154PRKCA0.29025286
155PRKG10.28877503
156PASK0.28491922
157MAP3K60.27980302
158RPS6KB10.26799196
159MST40.26308668
160CHEK20.25806988
161GRK50.25469637
162CDK80.24655686

Predicted pathways (KEGG)

RankGene SetZ-score
1Inflammatory bowel disease (IBD)_Homo sapiens_hsa053214.62186459
2Primary immunodeficiency_Homo sapiens_hsa053403.59576078
3DNA replication_Homo sapiens_hsa030303.15335552
4Allograft rejection_Homo sapiens_hsa053303.08101296
5Asthma_Homo sapiens_hsa053103.06604016
6Ribosome_Homo sapiens_hsa030103.02702109
7Maturity onset diabetes of the young_Homo sapiens_hsa049503.00777016
8Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.78580787
9Phototransduction_Homo sapiens_hsa047442.73426091
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.70592610
11Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.61597995
12Mismatch repair_Homo sapiens_hsa034302.49447317
13Nitrogen metabolism_Homo sapiens_hsa009102.47018657
14Linoleic acid metabolism_Homo sapiens_hsa005912.42775677
15Butanoate metabolism_Homo sapiens_hsa006502.35204670
16Antigen processing and presentation_Homo sapiens_hsa046122.35157828
17alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.26863177
18Oxidative phosphorylation_Homo sapiens_hsa001902.23095557
19Jak-STAT signaling pathway_Homo sapiens_hsa046302.22025198
20Hematopoietic cell lineage_Homo sapiens_hsa046402.17775371
21B cell receptor signaling pathway_Homo sapiens_hsa046622.12567426
22NF-kappa B signaling pathway_Homo sapiens_hsa040642.09949049
23Measles_Homo sapiens_hsa051622.01983774
24Base excision repair_Homo sapiens_hsa034101.93648003
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.93186569
26Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.89919593
27Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.84206291
28Caffeine metabolism_Homo sapiens_hsa002321.83399054
29Selenocompound metabolism_Homo sapiens_hsa004501.81776839
30Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.74426318
31T cell receptor signaling pathway_Homo sapiens_hsa046601.70239002
32Herpes simplex infection_Homo sapiens_hsa051681.67822404
33Ether lipid metabolism_Homo sapiens_hsa005651.66169113
34Parkinsons disease_Homo sapiens_hsa050121.64108811
35Osteoclast differentiation_Homo sapiens_hsa043801.61064332
36Tryptophan metabolism_Homo sapiens_hsa003801.57245886
37Nicotine addiction_Homo sapiens_hsa050331.56448873
38RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.56231091
39Leishmaniasis_Homo sapiens_hsa051401.55004984
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.45931293
41RNA polymerase_Homo sapiens_hsa030201.44996779
42Protein export_Homo sapiens_hsa030601.44229703
43Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.42382015
44Pyrimidine metabolism_Homo sapiens_hsa002401.41879891
45Autoimmune thyroid disease_Homo sapiens_hsa053201.37774479
46Graft-versus-host disease_Homo sapiens_hsa053321.37705742
47Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.34999943
48Type I diabetes mellitus_Homo sapiens_hsa049401.32015051
49Olfactory transduction_Homo sapiens_hsa047401.28266866
50Proteasome_Homo sapiens_hsa030501.28042202
51Taste transduction_Homo sapiens_hsa047421.27782804
52Legionellosis_Homo sapiens_hsa051341.26950424
53Homologous recombination_Homo sapiens_hsa034401.26124802
54Basal transcription factors_Homo sapiens_hsa030221.24913234
55Acute myeloid leukemia_Homo sapiens_hsa052211.22480798
56Toxoplasmosis_Homo sapiens_hsa051451.21552357
57Non-homologous end-joining_Homo sapiens_hsa034501.18731982
58Spliceosome_Homo sapiens_hsa030401.18389280
59ABC transporters_Homo sapiens_hsa020101.16086703
60Fatty acid elongation_Homo sapiens_hsa000621.15991388
61Influenza A_Homo sapiens_hsa051641.13325356
62Transcriptional misregulation in cancer_Homo sapiens_hsa052021.13100044
63Arachidonic acid metabolism_Homo sapiens_hsa005901.06013173
64Alzheimers disease_Homo sapiens_hsa050101.05659145
65Steroid hormone biosynthesis_Homo sapiens_hsa001401.04821288
66Apoptosis_Homo sapiens_hsa042101.03547021
67TNF signaling pathway_Homo sapiens_hsa046681.01417028
68Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.00544649
69Regulation of autophagy_Homo sapiens_hsa041400.97718691
70Huntingtons disease_Homo sapiens_hsa050160.96218614
71RNA degradation_Homo sapiens_hsa030180.96121218
72Epstein-Barr virus infection_Homo sapiens_hsa051690.95452199
73Chemokine signaling pathway_Homo sapiens_hsa040620.95420624
74Toll-like receptor signaling pathway_Homo sapiens_hsa046200.95212737
75Cardiac muscle contraction_Homo sapiens_hsa042600.95080322
76Hepatitis B_Homo sapiens_hsa051610.94529039
77Serotonergic synapse_Homo sapiens_hsa047260.92034040
78Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.91276462
79Peroxisome_Homo sapiens_hsa041460.89947895
80Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.89850580
81Platelet activation_Homo sapiens_hsa046110.89646387
82Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.89059915
83Morphine addiction_Homo sapiens_hsa050320.88597987
84Chemical carcinogenesis_Homo sapiens_hsa052040.84398876
85p53 signaling pathway_Homo sapiens_hsa041150.83944238
86Nucleotide excision repair_Homo sapiens_hsa034200.83692939
87Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.81999972
88Circadian rhythm_Homo sapiens_hsa047100.81040233
89Retinol metabolism_Homo sapiens_hsa008300.78638516
90Propanoate metabolism_Homo sapiens_hsa006400.77081440
91N-Glycan biosynthesis_Homo sapiens_hsa005100.76500635
92Basal cell carcinoma_Homo sapiens_hsa052170.76087685
93Collecting duct acid secretion_Homo sapiens_hsa049660.75507008
94NOD-like receptor signaling pathway_Homo sapiens_hsa046210.75314132
95Ovarian steroidogenesis_Homo sapiens_hsa049130.73015673
96Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.71457053
97Sulfur metabolism_Homo sapiens_hsa009200.70851365
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.69932630
99Shigellosis_Homo sapiens_hsa051310.69757375
100Prolactin signaling pathway_Homo sapiens_hsa049170.69151853
101Viral myocarditis_Homo sapiens_hsa054160.68077112
102Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.67936759
103Fanconi anemia pathway_Homo sapiens_hsa034600.67603351
104Other glycan degradation_Homo sapiens_hsa005110.66853176
105Salmonella infection_Homo sapiens_hsa051320.65677348
106Pentose phosphate pathway_Homo sapiens_hsa000300.64825793
107Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.64020455
108Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.63885720
109Circadian entrainment_Homo sapiens_hsa047130.62454192
110Insulin secretion_Homo sapiens_hsa049110.62022251
111Glutamatergic synapse_Homo sapiens_hsa047240.61550338
112Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.61535429
113Hedgehog signaling pathway_Homo sapiens_hsa043400.60846225
114Viral carcinogenesis_Homo sapiens_hsa052030.60184462
115Pertussis_Homo sapiens_hsa051330.60027905
116Leukocyte transendothelial migration_Homo sapiens_hsa046700.59000675
117Malaria_Homo sapiens_hsa051440.57212556
118Cell cycle_Homo sapiens_hsa041100.56996748
119Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.55909847
120Staphylococcus aureus infection_Homo sapiens_hsa051500.55545060
121GABAergic synapse_Homo sapiens_hsa047270.55186653
122Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.53468701
123Glycerolipid metabolism_Homo sapiens_hsa005610.53379633
124HTLV-I infection_Homo sapiens_hsa051660.53258811
125Dorso-ventral axis formation_Homo sapiens_hsa043200.51659882
126Tuberculosis_Homo sapiens_hsa051520.51490629
127Primary bile acid biosynthesis_Homo sapiens_hsa001200.50530657
128Calcium signaling pathway_Homo sapiens_hsa040200.49918557
129Neurotrophin signaling pathway_Homo sapiens_hsa047220.49851873
130Cocaine addiction_Homo sapiens_hsa050300.49095999
131Vitamin digestion and absorption_Homo sapiens_hsa049770.48977559
132Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.46552223
133Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.46245070
134Metabolic pathways_Homo sapiens_hsa011000.44982748
135Systemic lupus erythematosus_Homo sapiens_hsa053220.44460691
136SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44171567
137Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.43782158
138Non-small cell lung cancer_Homo sapiens_hsa052230.43740647
139Histidine metabolism_Homo sapiens_hsa003400.43167691
140Fat digestion and absorption_Homo sapiens_hsa049750.41210092
141Pentose and glucuronate interconversions_Homo sapiens_hsa000400.40385253
142Purine metabolism_Homo sapiens_hsa002300.39396733
143Pancreatic cancer_Homo sapiens_hsa052120.38875243
144Hepatitis C_Homo sapiens_hsa051600.38169141
145Amphetamine addiction_Homo sapiens_hsa050310.37945927
146beta-Alanine metabolism_Homo sapiens_hsa004100.35562613
147Renin-angiotensin system_Homo sapiens_hsa046140.35409722
148Salivary secretion_Homo sapiens_hsa049700.34960414
149Chronic myeloid leukemia_Homo sapiens_hsa052200.31830566
150Rheumatoid arthritis_Homo sapiens_hsa053230.30040741
151Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.28508297
152Mineral absorption_Homo sapiens_hsa049780.28184092
153Drug metabolism - other enzymes_Homo sapiens_hsa009830.27688891
154Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.27434914
155Thyroid cancer_Homo sapiens_hsa052160.26366104
156Sulfur relay system_Homo sapiens_hsa041220.24323016
157Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.23595626
158Glycerophospholipid metabolism_Homo sapiens_hsa005640.23164821
159Colorectal cancer_Homo sapiens_hsa052100.20724135
160Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.19426526
161One carbon pool by folate_Homo sapiens_hsa006700.17549029
162Small cell lung cancer_Homo sapiens_hsa052220.15913801
163RNA transport_Homo sapiens_hsa030130.14388118
164Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.14223759
165African trypanosomiasis_Homo sapiens_hsa051430.13653960
166Inositol phosphate metabolism_Homo sapiens_hsa005620.11894991
167Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.11177027
168VEGF signaling pathway_Homo sapiens_hsa043700.10865784
169AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.10020182

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