ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribonucleoprotein complex disassembly (GO:0032988)	6.33507463
2	platelet dense granule organization (GO:0060155)	5.18171985
3	glycerophospholipid catabolic process (GO:0046475)	5.16321320
4	organelle disassembly (GO:1903008)	4.74857943
5	tryptophan catabolic process (GO:0006569)	4.68599984
6	indole-containing compound catabolic process (GO:0042436)	4.68599984
7	indolalkylamine catabolic process (GO:0046218)	4.68599984
8	behavioral response to nicotine (GO:0035095)	4.48373741
9	kynurenine metabolic process (GO:0070189)	4.40814698
10	DNA deamination (GO:0045006)	4.33670404
11	gamma-aminobutyric acid transport (GO:0015812)	4.28143548
12	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO	4.25314473
13	tryptophan metabolic process (GO:0006568)	4.23166249
14	indolalkylamine metabolic process (GO:0006586)	4.12420335
15	negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)	4.11495248
16	negative regulation of execution phase of apoptosis (GO:1900118)	3.91733922
17	negative regulation of synaptic transmission, GABAergic (GO:0032229)	3.83583103
18	parturition (GO:0007567)	3.83393112
19	detection of light stimulus involved in sensory perception (GO:0050962)	3.78891618
20	detection of light stimulus involved in visual perception (GO:0050908)	3.78891618
21	prenylation (GO:0097354)	3.73766412
22	protein prenylation (GO:0018342)	3.73766412
23	regulation of isotype switching to IgG isotypes (GO:0048302)	3.68335343
24	phosphatidylserine acyl-chain remodeling (GO:0036150)	3.62216831
25	righting reflex (GO:0060013)	3.57577937
26	immunoglobulin mediated immune response (GO:0016064)	3.50347465
27	purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)	3.46797829
28	positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902110	3.43244012
29	mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)	3.43244012
30	GTP biosynthetic process (GO:0006183)	3.38988710
31	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.38194756
32	positive regulation of inflammatory response to antigenic stimulus (GO:0002863)	3.36617114
33	phosphatidylethanolamine acyl-chain remodeling (GO:0036152)	3.33372815
34	negative regulation of chemokine production (GO:0032682)	3.32566872
35	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.30474440
36	phosphatidylcholine acyl-chain remodeling (GO:0036151)	3.26597543
37	dopamine transport (GO:0015872)	3.26330691
38	amine catabolic process (GO:0009310)	3.22301622
39	cellular biogenic amine catabolic process (GO:0042402)	3.22301622
40	ribosomal small subunit assembly (GO:0000028)	3.22221371
41	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	3.22002007
42	synaptic transmission, cholinergic (GO:0007271)	3.21839371
43	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.17002308
44	signal peptide processing (GO:0006465)	3.13802462
45	positive regulation of cAMP-mediated signaling (GO:0043950)	3.12673348
46	sleep (GO:0030431)	3.11704408
47	phosphatidylinositol acyl-chain remodeling (GO:0036149)	3.09267255
48	aggressive behavior (GO:0002118)	3.08450874
49	fucose catabolic process (GO:0019317)	3.07821698
50	L-fucose metabolic process (GO:0042354)	3.07821698
51	L-fucose catabolic process (GO:0042355)	3.07821698
52	reflex (GO:0060004)	2.98614938
53	icosanoid secretion (GO:0032309)	2.95389684
54	arachidonic acid secretion (GO:0050482)	2.95389684
55	cytokine biosynthetic process (GO:0042089)	2.94296301
56	T cell migration (GO:0072678)	2.93509615
57	seminiferous tubule development (GO:0072520)	2.91988535
58	mannosylation (GO:0097502)	2.91880227
59	preassembly of GPI anchor in ER membrane (GO:0016254)	2.91832740
60	electron transport chain (GO:0022900)	2.88627393
61	positive regulation of isotype switching (GO:0045830)	2.88388396
62	regulation of execution phase of apoptosis (GO:1900117)	2.86359936
63	cytolysis (GO:0019835)	2.86328466
64	ATP synthesis coupled proton transport (GO:0015986)	2.84808981
65	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.84808981
66	indole-containing compound metabolic process (GO:0042430)	2.84170001
67	respiratory electron transport chain (GO:0022904)	2.82532721
68	negative regulation of interleukin-8 production (GO:0032717)	2.80987025
69	UTP biosynthetic process (GO:0006228)	2.80815965
70	regulation of chronic inflammatory response (GO:0002676)	2.78362122
71	positive regulation of protein homodimerization activity (GO:0090073)	2.77615543
72	metallo-sulfur cluster assembly (GO:0031163)	2.77026489
73	iron-sulfur cluster assembly (GO:0016226)	2.77026489
74	negative regulation of mast cell activation (GO:0033004)	2.75864811
75	negative regulation of calcium ion transport into cytosol (GO:0010523)	2.74762879
76	lymphocyte chemotaxis (GO:0048247)	2.74005387
77	neuronal action potential (GO:0019228)	2.73083439
78	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.72587176
79	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.71594570
80	benzene-containing compound metabolic process (GO:0042537)	2.71399379
81	UTP metabolic process (GO:0046051)	2.71041241
82	B cell mediated immunity (GO:0019724)	2.69830127
83	anterograde synaptic vesicle transport (GO:0048490)	2.67944620
84	ncRNA 3-end processing (GO:0043628)	2.66359775
85	negative regulation of telomere maintenance (GO:0032205)	2.65044267
86	receptor guanylyl cyclase signaling pathway (GO:0007168)	2.64050278
87	serotonin receptor signaling pathway (GO:0007210)	2.62177447
88	positive regulation of DNA recombination (GO:0045911)	2.60771244
89	regulation of hypersensitivity (GO:0002883)	2.59931061
90	phospholipid catabolic process (GO:0009395)	2.57895484
91	regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)	2.57736787
92	protein import into peroxisome matrix (GO:0016558)	2.57618786
93	adenosine metabolic process (GO:0046085)	2.55050778
94	piRNA metabolic process (GO:0034587)	2.54952780
95	purine deoxyribonucleotide metabolic process (GO:0009151)	2.53843747
96	DNA dealkylation (GO:0035510)	2.52358522
97	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	2.52103754
98	phosphatidylglycerol acyl-chain remodeling (GO:0036148)	2.49793445
99	negative regulation of acute inflammatory response (GO:0002674)	2.49404133
100	behavioral response to ethanol (GO:0048149)	2.49226058

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	VDR_22108803_ChIP-Seq_LS180_Human	4.42782696
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.26313288
3	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.07888081
4	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.02708431
5	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.46206059
6	FUS_26573619_Chip-Seq_HEK293_Human	2.36348173
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.33237903
8	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.30915544
9	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.28087102
10	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.25135026
11	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.20216451
12	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.18983744
13	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.02374126
14	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.93231354
15	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.85804686
16	GBX2_23144817_ChIP-Seq_PC3_Human	1.82710916
17	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.78056799
18	IGF1R_20145208_ChIP-Seq_DFB_Human	1.71627216
19	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.71213811
20	TAF15_26573619_Chip-Seq_HEK293_Human	1.70337178
21	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.68683133
22	VDR_23849224_ChIP-Seq_CD4+_Human	1.67991550
23	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.64577270
24	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.59167844
25	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.49531025
26	TP53_22573176_ChIP-Seq_HFKS_Human	1.49199921
27	EWS_26573619_Chip-Seq_HEK293_Human	1.49072957
28	GATA3_26560356_Chip-Seq_TH2_Human	1.48367573
29	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.46613621
30	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.45800686
31	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.45479248
32	CBP_20019798_ChIP-Seq_JUKART_Human	1.44676963
33	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.44676963
34	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.44464870
35	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.44035400
36	ELK1_19687146_ChIP-ChIP_HELA_Human	1.43936155
37	P300_19829295_ChIP-Seq_ESCs_Human	1.43376371
38	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.42793046
39	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.42793046
40	TAF2_19829295_ChIP-Seq_ESCs_Human	1.42655348
41	NCOR_22424771_ChIP-Seq_293T_Human	1.40995765
42	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.40839606
43	MYC_18940864_ChIP-ChIP_HL60_Human	1.40706053
44	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.40440719
45	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.39697421
46	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.38165292
47	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.38165292
48	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.36528522
49	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.34225159
50	AR_20517297_ChIP-Seq_VCAP_Human	1.33978937
51	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.33666160
52	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.33527194
53	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.33112051
54	RNF2_27304074_Chip-Seq_NSC_Mouse	1.32858854
55	IRF1_19129219_ChIP-ChIP_H3396_Human	1.30945803
56	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.30911139
57	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.30390380
58	MYC_19829295_ChIP-Seq_ESCs_Human	1.29282056
59	FOXP3_21729870_ChIP-Seq_TREG_Human	1.28375064
60	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.26451235
61	SOX2_19829295_ChIP-Seq_ESCs_Human	1.25767337
62	NANOG_19829295_ChIP-Seq_ESCs_Human	1.25767337
63	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.25344347
64	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.24014657
65	REST_21632747_ChIP-Seq_MESCs_Mouse	1.21835743
66	ERG_20517297_ChIP-Seq_VCAP_Human	1.20939078
67	ER_23166858_ChIP-Seq_MCF-7_Human	1.20667662
68	ERA_21632823_ChIP-Seq_H3396_Human	1.15694464
69	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.15285400
70	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.12513717
71	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.12153503
72	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.08399830
73	STAT3_23295773_ChIP-Seq_U87_Human	1.07555414
74	BCAT_22108803_ChIP-Seq_LS180_Human	1.06464939
75	RAC3_21632823_ChIP-Seq_H3396_Human	1.06017825
76	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.05064474
77	RBPJ_21746931_ChIP-Seq_IB4_Human	1.04711549
78	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.04578347
79	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.00406729
80	TCF4_22108803_ChIP-Seq_LS180_Human	1.00339388
81	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.97163106
82	KAP1_22055183_ChIP-Seq_ESCs_Mouse	0.97060776
83	SALL4_22934838_ChIP-ChIP_CD34+_Human	0.96513210
84	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.95282031
85	HTT_18923047_ChIP-ChIP_STHdh_Human	0.95155018
86	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.94142967
87	ETV1_20927104_ChIP-Seq_GIST48_Human	0.93715989
88	SRF_21415370_ChIP-Seq_HL-1_Mouse	0.93260313
89	IKZF1_21737484_ChIP-ChIP_HCT116_Human	0.92950150
90	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.92526689
91	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.92163629
92	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.91542350
93	P53_21459846_ChIP-Seq_SAOS-2_Human	0.90180596
94	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	0.89575930
95	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.89255786
96	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.89086859
97	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.87031669
98	EZH2_22144423_ChIP-Seq_EOC_Human	0.86808047
99	CBX2_22325352_ChIP-Seq_293T-Rex_Human	0.86185823
100	SMAD4_21799915_ChIP-Seq_A2780_Human	0.85951936

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0001986_abnormal_taste_sensitivity	3.74748062
2	MP0003195_calcinosis	3.21414392
3	MP0000372_irregular_coat_pigmentation	3.13290017
4	MP0000569_abnormal_digit_pigmentation	3.10925186
5	MP0005671_abnormal_response_to	2.99623549
6	MP0002102_abnormal_ear_morphology	2.43039836
7	MP0001529_abnormal_vocalization	2.31892091
8	MP0004885_abnormal_endolymph	2.21361134
9	MP0009046_muscle_twitch	2.13616030
10	MP0005551_abnormal_eye_electrophysiolog	2.03828900
11	MP0001835_abnormal_antigen_presentation	1.98334717
12	MP0003646_muscle_fatigue	1.95453406
13	MP0002138_abnormal_hepatobiliary_system	1.83919153
14	MP0005451_abnormal_body_composition	1.81497759
15	MP0004043_abnormal_pH_regulation	1.74686461
16	MP0004145_abnormal_muscle_electrophysio	1.73629490
17	MP0001486_abnormal_startle_reflex	1.73499594
18	MP0006036_abnormal_mitochondrial_physio	1.68584751
19	MP0003045_fibrosis	1.66083592
20	MP0003137_abnormal_impulse_conducting	1.59724198
21	MP0002272_abnormal_nervous_system	1.58334592
22	MP0009745_abnormal_behavioral_response	1.56817453
23	MP0002095_abnormal_skin_pigmentation	1.56591181
24	MP0008875_abnormal_xenobiotic_pharmacok	1.56226875
25	MP0008995_early_reproductive_senescence	1.54008550
26	MP0002163_abnormal_gland_morphology	1.51698565
27	MP0004859_abnormal_synaptic_plasticity	1.50333493
28	MP0005253_abnormal_eye_physiology	1.49282063
29	MP0001664_abnormal_digestion	1.47692268
30	MP0000015_abnormal_ear_pigmentation	1.44838347
31	MP0000427_abnormal_hair_cycle	1.44741862
32	MP0002277_abnormal_respiratory_mucosa	1.44713316
33	MP0003567_abnormal_fetal_cardiomyocyte	1.44070565
34	MP0008872_abnormal_physiological_respon	1.37752682
35	MP0003656_abnormal_erythrocyte_physiolo	1.33178626
36	MP0009785_altered_susceptibility_to	1.32181941
37	MP0000647_abnormal_sebaceous_gland	1.32154683
38	MP0001968_abnormal_touch/_nociception	1.31935574
39	MP0001905_abnormal_dopamine_level	1.30845030
40	MP0003879_abnormal_hair_cell	1.29467409
41	MP0008775_abnormal_heart_ventricle	1.26970473
42	MP0004484_altered_response_of	1.26772229
43	MP0005075_abnormal_melanosome_morpholog	1.25586305
44	MP0004924_abnormal_behavior	1.24767156
45	MP0005386_behavior/neurological_phenoty	1.24767156
46	MP0010386_abnormal_urinary_bladder	1.24409210
47	MP0003718_maternal_effect	1.23969540
48	MP0003300_gastrointestinal_ulcer	1.23923301
49	MP0002733_abnormal_thermal_nociception	1.23024220
50	MP0002735_abnormal_chemical_nociception	1.22426772
51	MP0002736_abnormal_nociception_after	1.20823948
52	MP0001970_abnormal_pain_threshold	1.20560639
53	MP0005379_endocrine/exocrine_gland_phen	1.19944185
54	MP0002876_abnormal_thyroid_physiology	1.18141681
55	MP0001440_abnormal_grooming_behavior	1.17725763
56	MP0001873_stomach_inflammation	1.15159227
57	MP0005332_abnormal_amino_acid	1.15016416
58	MP0008961_abnormal_basal_metabolism	1.13638359
59	MP0001188_hyperpigmentation	1.12252872
60	MP0000639_abnormal_adrenal_gland	1.11809877
61	MP0002064_seizures	1.11673289
62	MP0003806_abnormal_nucleotide_metabolis	1.10725340
63	MP0002928_abnormal_bile_duct	1.08921200
64	MP0001764_abnormal_homeostasis	1.08426690
65	MP0006072_abnormal_retinal_apoptosis	1.07744945
66	MP0002106_abnormal_muscle_physiology	1.06853330
67	MP0000383_abnormal_hair_follicle	1.06048703
68	MP0002572_abnormal_emotion/affect_behav	1.06030770
69	MP0002557_abnormal_social/conspecific_i	1.05415384
70	MP0004215_abnormal_myocardial_fiber	1.03751445
71	MP0002282_abnormal_trachea_morphology	1.03275888
72	MP0002090_abnormal_vision	1.01241003
73	MP0006276_abnormal_autonomic_nervous	1.00751956
74	MP0004142_abnormal_muscle_tone	0.96496180
75	MP0009764_decreased_sensitivity_to	0.96473682
76	MP0001765_abnormal_ion_homeostasis	0.95350140
77	MP0002148_abnormal_hypersensitivity_rea	0.94940916
78	MP0005646_abnormal_pituitary_gland	0.93566886
79	MP0005165_increased_susceptibility_to	0.92907543
80	MP0006082_CNS_inflammation	0.92199935
81	MP0005174_abnormal_tail_pigmentation	0.91491782
82	MP0005310_abnormal_salivary_gland	0.87636958
83	MP0002822_catalepsy	0.86675452
84	MP0005025_abnormal_response_to	0.86199697
85	MP0002332_abnormal_exercise_endurance	0.85545224
86	MP0004085_abnormal_heartbeat	0.82173420
87	MP0000343_altered_response_to	0.81496348
88	MP0002734_abnormal_mechanical_nocicepti	0.79238485
89	MP0000538_abnormal_urinary_bladder	0.78756441
90	MP0004084_abnormal_cardiac_muscle	0.78446722
91	MP0005369_muscle_phenotype	0.76965909
92	MP0000230_abnormal_systemic_arterial	0.74670724
93	MP0002166_altered_tumor_susceptibility	0.74565883
94	MP0003252_abnormal_bile_duct	0.74156287
95	MP0001348_abnormal_lacrimal_gland	0.73817689
96	MP0006035_abnormal_mitochondrial_morpho	0.72850484
97	MP0008877_abnormal_DNA_methylation	0.72828837
98	MP0001501_abnormal_sleep_pattern	0.72807483
99	MP0005167_abnormal_blood-brain_barrier	0.70978329
100	MP0000013_abnormal_adipose_tissue	0.70878908

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Decreased central vision (HP:0007663)	4.34957662
2	Decreased electroretinogram (ERG) amplitude (HP:0000654)	4.11652313
3	Abnormality of aspartate family amino acid metabolism (HP:0010899)	4.10773957
4	Hypothermia (HP:0002045)	4.06038921
5	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.95844616
6	Methylmalonic acidemia (HP:0002912)	3.84174415
7	Focal motor seizures (HP:0011153)	3.72133040
8	Acute necrotizing encephalopathy (HP:0006965)	3.58995382
9	Aplastic anemia (HP:0001915)	3.58101145
10	Homocystinuria (HP:0002156)	3.41356960
11	Abnormality of homocysteine metabolism (HP:0010919)	3.41356960
12	Congenital stationary night blindness (HP:0007642)	3.32126154
13	Acute encephalopathy (HP:0006846)	3.19821743
14	Generalized aminoaciduria (HP:0002909)	3.19644123
15	Abnormal mitochondria in muscle tissue (HP:0008316)	3.11664894
16	Elevated erythrocyte sedimentation rate (HP:0003565)	3.10729729
17	Type 2 muscle fiber atrophy (HP:0003554)	3.06443605
18	Pancreatic cysts (HP:0001737)	3.04952741
19	Abnormal rod and cone electroretinograms (HP:0008323)	3.01074074
20	Progressive macrocephaly (HP:0004481)	2.91415885
21	Type II lissencephaly (HP:0007260)	2.87944374
22	Methylmalonic aciduria (HP:0012120)	2.80627715
23	CNS hypomyelination (HP:0003429)	2.75954480
24	True hermaphroditism (HP:0010459)	2.75757360
25	Visual hallucinations (HP:0002367)	2.70733100
26	Pancreatic fibrosis (HP:0100732)	2.68556415
27	Keratoconus (HP:0000563)	2.68511972
28	Increased corneal curvature (HP:0100692)	2.68511972
29	Mitral stenosis (HP:0001718)	2.64923834
30	Increased CSF lactate (HP:0002490)	2.60887323
31	Muscle fiber atrophy (HP:0100295)	2.59198837
32	Absent/shortened dynein arms (HP:0200106)	2.57541212
33	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.57541212
34	Chronic hepatic failure (HP:0100626)	2.56582471
35	Abnormality of the prostate (HP:0008775)	2.48053637
36	Attenuation of retinal blood vessels (HP:0007843)	2.47956387
37	Opisthotonus (HP:0002179)	2.46628274
38	Focal seizures (HP:0007359)	2.43676706
39	Mitochondrial inheritance (HP:0001427)	2.41822315
40	Inability to walk (HP:0002540)	2.40482448
41	Abolished electroretinogram (ERG) (HP:0000550)	2.36875143
42	Cerebral edema (HP:0002181)	2.33158167
43	Abnormality of midbrain morphology (HP:0002418)	2.32298238
44	Molar tooth sign on MRI (HP:0002419)	2.32298238
45	Tongue fasciculations (HP:0001308)	2.31187734
46	Abnormality of methionine metabolism (HP:0010901)	2.30342388
47	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.28537923
48	Abnormal respiratory epithelium morphology (HP:0012253)	2.25515105
49	Abnormal respiratory motile cilium morphology (HP:0005938)	2.25515105
50	Dialeptic seizures (HP:0011146)	2.23344329
51	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.20067112
52	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.20067112
53	Abnormality of the pubic bones (HP:0003172)	2.19290131
54	Portal hypertension (HP:0001409)	2.18930634
55	Hepatic necrosis (HP:0002605)	2.16064792
56	Sclerocornea (HP:0000647)	2.15233693
57	Absence seizures (HP:0002121)	2.14026647
58	Increased serum lactate (HP:0002151)	2.12014755
59	Type I transferrin isoform profile (HP:0003642)	2.10596163
60	Congenital, generalized hypertrichosis (HP:0004540)	2.10403063
61	Aplasia/Hypoplasia of the macula (HP:0008059)	2.10358437
62	Bony spicule pigmentary retinopathy (HP:0007737)	2.10301852
63	Hepatocellular necrosis (HP:0001404)	2.09930107
64	Palpitations (HP:0001962)	2.09770649
65	Constricted visual fields (HP:0001133)	2.09631173
66	Abnormality of vitamin B metabolism (HP:0004340)	2.09476809
67	Abnormality of sulfur amino acid metabolism (HP:0004339)	2.08465858
68	Aplasia/Hypoplasia affecting the retina (HP:0008061)	2.07885460
69	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.07841735
70	Abnormality of serum amino acid levels (HP:0003112)	2.07787384
71	Cystic liver disease (HP:0006706)	2.07430066
72	Lethargy (HP:0001254)	2.04761336
73	Optic disc pallor (HP:0000543)	2.00303800
74	Late onset (HP:0003584)	1.97019340
75	Abnormality of the hepatic vasculature (HP:0006707)	1.96423673
76	Menstrual irregularities (HP:0000858)	1.95606725
77	Retinal dysplasia (HP:0007973)	1.93722091
78	Leukodystrophy (HP:0002415)	1.92615104
79	Muscle fibrillation (HP:0010546)	1.90331289
80	Pachygyria (HP:0001302)	1.90260419
81	Pendular nystagmus (HP:0012043)	1.89592896
82	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	1.87883052
83	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.87186010
84	Abnormal protein N-linked glycosylation (HP:0012347)	1.87186010
85	Abnormal protein glycosylation (HP:0012346)	1.87186010
86	Abnormal glycosylation (HP:0012345)	1.87186010
87	Fibular aplasia (HP:0002990)	1.86536442
88	Occipital encephalocele (HP:0002085)	1.86385941
89	Nephronophthisis (HP:0000090)	1.85597700
90	Brushfield spots (HP:0001088)	1.85512466
91	Lactic acidosis (HP:0003128)	1.84630912
92	Myokymia (HP:0002411)	1.82120775
93	Cerebellar dysplasia (HP:0007033)	1.81365078
94	Limb dystonia (HP:0002451)	1.81317048
95	Lissencephaly (HP:0001339)	1.81252620
96	Nonprogressive disorder (HP:0003680)	1.81204874
97	Large for gestational age (HP:0001520)	1.80440054
98	Neonatal respiratory distress (HP:0002643)	1.77821641
99	Prostate neoplasm (HP:0100787)	1.75261663
100	Generalized tonic-clonic seizures (HP:0002069)	1.75145158

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	STK16	7.89472712
2	BCKDK	3.57718497
3	FRK	3.18278386
4	TAOK3	2.82609589
5	MAP4K2	2.74963515
6	ADRBK2	2.61205458
7	PIK3CG	2.32759912
8	RIPK4	2.23003193
9	LMTK2	2.05635235
10	TLK1	1.97563741
11	MKNK1	1.82470210
12	ITK	1.70522362
13	NME1	1.47616378
14	STK38L	1.47176288
15	BMPR1B	1.42372387
16	ZAK	1.41989467
17	BMPR2	1.36368319
18	MAPK13	1.31731362
19	OBSCN	1.28100634
20	MKNK2	1.27709284
21	GRK1	1.22494120
22	MAPKAPK5	1.21070866
23	TXK	1.18697100
24	NEK1	1.16515681
25	SIK3	1.15018781
26	CAMKK2	1.09031060
27	ILK	1.06881439
28	AKT3	1.06664611
29	WNK3	1.06556117
30	NUAK1	1.05482221
31	CDK8	1.03188477
32	TRPM7	0.98492870
33	ERBB3	0.96648858
34	PRKCE	0.94121275
35	BCR	0.93206833
36	ADRBK1	0.91540219
37	BRSK2	0.88775885
38	CSNK1A1L	0.88385720
39	MAPKAPK3	0.87959224
40	FES	0.87506599
41	PBK	0.87078228
42	MAP3K12	0.86283207
43	CSNK1G3	0.85805221
44	CAMK2A	0.82157926
45	IKBKB	0.78875190
46	KIT	0.76669305
47	PRKCG	0.76195815
48	PKN2	0.75868815
49	CSNK1G2	0.75484167
50	MYLK	0.74924892
51	DAPK1	0.74258597
52	CLK1	0.72364310
53	MAP2K7	0.71698102
54	SYK	0.69543325
55	TEC	0.69475592
56	PIK3CA	0.68347775
57	FLT3	0.67027991
58	WNK4	0.65800785
59	LYN	0.64219456
60	PHKG2	0.64194121
61	PHKG1	0.64194121
62	MAP3K4	0.64093552
63	LCK	0.62597352
64	PKN1	0.61745381
65	IGF1R	0.60912267
66	PRKG1	0.60670704
67	DAPK3	0.59548717
68	TSSK6	0.57813133
69	PINK1	0.56816887
70	TIE1	0.56705751
71	OXSR1	0.55789059
72	INSRR	0.55601117
73	RPS6KA5	0.54514501
74	KDR	0.54363874
75	TRIM28	0.54046576
76	CDK4	0.53783393
77	ACVR1B	0.53265447
78	GRK5	0.50726382
79	PRKACG	0.50428378
80	NTRK3	0.49863564
81	EIF2AK1	0.49561896
82	MAP2K6	0.49488891
83	PRKACA	0.47794860
84	DDR2	0.47590806
85	CSNK1G1	0.47535155
86	PRKCA	0.47223895
87	PLK2	0.47202135
88	MINK1	0.46977085
89	SRPK1	0.46254127
90	JAK3	0.45256713
91	EGFR	0.44729410
92	PTK2B	0.44246856
93	CCNB1	0.44163190
94	PRKCQ	0.43335748
95	BRD4	0.42819162
96	STK39	0.42643370
97	FER	0.39147486
98	TBK1	0.39033211
99	ABL1	0.38772265
100	GRK7	0.38375785

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Asthma_Homo sapiens_hsa05310	4.58117462
2	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	3.63892698
3	Allograft rejection_Homo sapiens_hsa05330	3.35201152
4	Autoimmune thyroid disease_Homo sapiens_hsa05320	3.21356609
5	Linoleic acid metabolism_Homo sapiens_hsa00591	2.80057176
6	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.79191400
7	Phototransduction_Homo sapiens_hsa04744	2.55990286
8	Type I diabetes mellitus_Homo sapiens_hsa04940	2.44716651
9	Oxidative phosphorylation_Homo sapiens_hsa00190	2.42844137
10	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.42524297
11	Graft-versus-host disease_Homo sapiens_hsa05332	2.36265817
12	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.10835218
13	Parkinsons disease_Homo sapiens_hsa05012	2.10358917
14	Nitrogen metabolism_Homo sapiens_hsa00910	1.84483639
15	One carbon pool by folate_Homo sapiens_hsa00670	1.76995347
16	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.71278513
17	Ether lipid metabolism_Homo sapiens_hsa00565	1.65587207
18	Peroxisome_Homo sapiens_hsa04146	1.61381321
19	Olfactory transduction_Homo sapiens_hsa04740	1.58940568
20	beta-Alanine metabolism_Homo sapiens_hsa00410	1.55665688
21	Nicotine addiction_Homo sapiens_hsa05033	1.45317281
22	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.38102965
23	Protein export_Homo sapiens_hsa03060	1.31589370
24	Butanoate metabolism_Homo sapiens_hsa00650	1.28922743
25	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.28402468
26	Legionellosis_Homo sapiens_hsa05134	1.27659363
27	Antigen processing and presentation_Homo sapiens_hsa04612	1.26230485
28	Viral myocarditis_Homo sapiens_hsa05416	1.24073514
29	Rheumatoid arthritis_Homo sapiens_hsa05323	1.23873003
30	Alzheimers disease_Homo sapiens_hsa05010	1.20289819
31	Cardiac muscle contraction_Homo sapiens_hsa04260	1.19487920
32	Tryptophan metabolism_Homo sapiens_hsa00380	1.18975929
33	RNA polymerase_Homo sapiens_hsa03020	1.17926259
34	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.17283414
35	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.11510462
36	Collecting duct acid secretion_Homo sapiens_hsa04966	1.10098397
37	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.08500578
38	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.04587284
39	Proteasome_Homo sapiens_hsa03050	1.01772228
40	Huntingtons disease_Homo sapiens_hsa05016	1.01275628
41	Histidine metabolism_Homo sapiens_hsa00340	1.00703051
42	Serotonergic synapse_Homo sapiens_hsa04726	1.00229510
43	Primary immunodeficiency_Homo sapiens_hsa05340	1.00000145
44	Caffeine metabolism_Homo sapiens_hsa00232	0.99917159
45	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.99706573
46	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.96684333
47	Ribosome_Homo sapiens_hsa03010	0.96454428
48	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.91790619
49	GABAergic synapse_Homo sapiens_hsa04727	0.90253737
50	Selenocompound metabolism_Homo sapiens_hsa00450	0.88448693
51	Purine metabolism_Homo sapiens_hsa00230	0.84334669
52	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.84031617
53	Morphine addiction_Homo sapiens_hsa05032	0.80821462
54	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.79659240
55	Glutathione metabolism_Homo sapiens_hsa00480	0.72765076
56	Propanoate metabolism_Homo sapiens_hsa00640	0.70675288
57	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.69109157
58	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.68460178
59	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.67759579
60	ABC transporters_Homo sapiens_hsa02010	0.65399898
61	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.64225027
62	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.62460604
63	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.59694957
64	Glutamatergic synapse_Homo sapiens_hsa04724	0.59509350
65	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.59197915
66	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.58085131
67	Sulfur relay system_Homo sapiens_hsa04122	0.55837304
68	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.55719487
69	Fanconi anemia pathway_Homo sapiens_hsa03460	0.55476998
70	Arginine biosynthesis_Homo sapiens_hsa00220	0.54306154
71	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.51734193
72	Retinol metabolism_Homo sapiens_hsa00830	0.50106264
73	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.50052011
74	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.48588732
75	Taste transduction_Homo sapiens_hsa04742	0.47891910
76	Pyrimidine metabolism_Homo sapiens_hsa00240	0.47163411
77	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.46865406
78	Long-term depression_Homo sapiens_hsa04730	0.45790299
79	Metabolic pathways_Homo sapiens_hsa01100	0.44965983
80	RNA degradation_Homo sapiens_hsa03018	0.44576007
81	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.43126728
82	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.42125835
83	Arginine and proline metabolism_Homo sapiens_hsa00330	0.42001982
84	Chemical carcinogenesis_Homo sapiens_hsa05204	0.41903688
85	Circadian entrainment_Homo sapiens_hsa04713	0.40060772
86	Homologous recombination_Homo sapiens_hsa03440	0.38949281
87	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.38618080
88	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.38378689
89	Calcium signaling pathway_Homo sapiens_hsa04020	0.36910135
90	Salivary secretion_Homo sapiens_hsa04970	0.34993380
91	Regulation of autophagy_Homo sapiens_hsa04140	0.34490191
92	Fatty acid degradation_Homo sapiens_hsa00071	0.33354147
93	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.32212304
94	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.32140955
95	Fat digestion and absorption_Homo sapiens_hsa04975	0.31873013
96	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.31353886
97	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.31155148
98	Leishmaniasis_Homo sapiens_hsa05140	0.28367074
99	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.27053353
100	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.25986580

CLNS1AP1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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