CLOCK

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene plays a central role in the regulation of circadian rhythms. The protein encodes a transcription factor of the basic helix-loop-helix (bHLH) family and contains DNA binding histone acetyltransferase activity. The encoded protein forms a heterodimer with ARNTL (BMAL1) that binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Polymorphisms in this gene may be associated with behavioral changes in certain populations and with obesity and metabolic syndrome. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic sister chromatid cohesion (GO:0007064)3.56126986
2positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.36900219
3regulation of short-term neuronal synaptic plasticity (GO:0048172)3.35925438
4regulation of meiosis I (GO:0060631)3.24380559
5positive regulation of protein autophosphorylation (GO:0031954)3.21340336
6regulation of acrosome reaction (GO:0060046)3.16504854
7positive regulation of mitotic sister chromatid separation (GO:1901970)3.11629986
8positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.11629986
9positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.11629986
10genitalia morphogenesis (GO:0035112)3.08531802
11locomotory exploration behavior (GO:0035641)3.01234567
12oocyte development (GO:0048599)2.98341829
13paraxial mesoderm development (GO:0048339)2.93535829
14interkinetic nuclear migration (GO:0022027)2.92016263
15regulation of Rac protein signal transduction (GO:0035020)2.88212071
16glutamate secretion (GO:0014047)2.86661484
17UDP-N-acetylglucosamine metabolic process (GO:0006047)2.85101812
18positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.83804036
19regulation of transforming growth factor beta2 production (GO:0032909)2.82837505
20protein targeting to Golgi (GO:0000042)2.81522398
21regulation of synaptic vesicle exocytosis (GO:2000300)2.80114085
22regulation of ARF protein signal transduction (GO:0032012)2.79120095
23nuclear pore organization (GO:0006999)2.76298751
24negative regulation of keratinocyte proliferation (GO:0010839)2.74995720
25retinal cone cell development (GO:0046549)2.74989876
26anterior/posterior axis specification, embryo (GO:0008595)2.73869425
27bundle of His cell to Purkinje myocyte communication (GO:0086069)2.71436384
28nuclear pore complex assembly (GO:0051292)2.71184447
29synaptic vesicle maturation (GO:0016188)2.70358560
30pericardium development (GO:0060039)2.68634027
31embryonic foregut morphogenesis (GO:0048617)2.66756045
32synaptic vesicle docking involved in exocytosis (GO:0016081)2.64038346
33protein K11-linked deubiquitination (GO:0035871)2.63643131
34establishment of protein localization to Golgi (GO:0072600)2.59644792
35smooth muscle tissue development (GO:0048745)2.58439958
36vocalization behavior (GO:0071625)2.57795552
37regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.56593125
38sister chromatid cohesion (GO:0007062)2.55816069
39Golgi to endosome transport (GO:0006895)2.51156264
40glutamate receptor signaling pathway (GO:0007215)2.50441612
41ionotropic glutamate receptor signaling pathway (GO:0035235)2.49785016
42cellular potassium ion homeostasis (GO:0030007)2.49691673
43vesicle transport along microtubule (GO:0047496)2.49040907
44hippo signaling (GO:0035329)2.48157498
45cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.47564322
46regulation of synaptic vesicle transport (GO:1902803)2.47562761
47retrograde transport, vesicle recycling within Golgi (GO:0000301)2.46361879
48macroautophagy (GO:0016236)2.44996433
49regulation of DNA methylation (GO:0044030)2.44978542
50synapsis (GO:0007129)2.44195964
51cerebellar Purkinje cell differentiation (GO:0021702)2.43984736
52intestinal epithelial cell development (GO:0060576)2.43558365
53negative regulation of hormone metabolic process (GO:0032351)2.42771982
54negative regulation of hormone biosynthetic process (GO:0032353)2.42771982
55synaptic vesicle exocytosis (GO:0016079)2.41582352
56membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.41519579
57regulation of glutamate receptor signaling pathway (GO:1900449)2.40480671
58regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.39954764
59innervation (GO:0060384)2.39767639
60protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.39458404
61negative regulation of DNA repair (GO:0045738)2.39399265
62regulation of DNA endoreduplication (GO:0032875)2.38846385
63G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.38163413
64regulation of cardioblast differentiation (GO:0051890)2.37495164
65detection of calcium ion (GO:0005513)2.37463848
66centrosome duplication (GO:0051298)2.37363583
67female gamete generation (GO:0007292)2.37295146
68regulation of clathrin-mediated endocytosis (GO:2000369)2.36558804
69meiotic cell cycle (GO:0051321)2.36270859
70lymphangiogenesis (GO:0001946)2.36092463
71synaptic transmission, glutamatergic (GO:0035249)2.34558414
72sequestering of extracellular ligand from receptor (GO:0035581)2.33545125
73regulation of keratinocyte proliferation (GO:0010837)2.33296657
74activation of protein kinase A activity (GO:0034199)2.33209946
75dendrite morphogenesis (GO:0048813)2.32718363
76regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.32709505
77regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.30513228
78regulation of beta-amyloid formation (GO:1902003)2.30333220
79regulation of centriole replication (GO:0046599)2.29715084
80COPII vesicle coating (GO:0048208)2.29376894
81establishment of nucleus localization (GO:0040023)2.28107270
82early endosome to late endosome transport (GO:0045022)2.28027826
83nodal signaling pathway (GO:0038092)2.27956384
84neuron-neuron synaptic transmission (GO:0007270)2.27022201
85establishment of chromosome localization (GO:0051303)2.25708375
86metaphase plate congression (GO:0051310)2.25486725
87positive regulation of meiosis (GO:0045836)2.25379847
88insulin-like growth factor receptor signaling pathway (GO:0048009)2.24893765
89synaptic vesicle endocytosis (GO:0048488)2.23515568
90neurotransmitter-gated ion channel clustering (GO:0072578)2.23484899
91monoubiquitinated protein deubiquitination (GO:0035520)2.22860213
92piRNA metabolic process (GO:0034587)2.22685865
93dorsal/ventral axis specification (GO:0009950)2.22305324
94chemosensory behavior (GO:0007635)2.22146784
95artery development (GO:0060840)2.22035739
96retina vasculature morphogenesis in camera-type eye (GO:0061299)2.21948191
97proline transport (GO:0015824)2.19427986
98cerebellar granule cell differentiation (GO:0021707)2.18287551
99neurotransmitter secretion (GO:0007269)2.18262884
100positive regulation of chromosome segregation (GO:0051984)2.18096609
101inner ear receptor cell development (GO:0060119)2.17961036
102positive regulation of vesicle fusion (GO:0031340)2.17880483
103positive regulation of macroautophagy (GO:0016239)2.17235440
104desmosome organization (GO:0002934)2.16751252
105neuronal action potential propagation (GO:0019227)2.16281388
106regulation of excitatory postsynaptic membrane potential (GO:0060079)2.15827050
107insulin secretion (GO:0030073)2.14482830
108mating behavior (GO:0007617)2.14249923
109histone-serine phosphorylation (GO:0035404)2.14125720
110presynaptic membrane assembly (GO:0097105)2.14000059
111relaxation of cardiac muscle (GO:0055119)2.13091134
112negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.12610572
113positive regulation of meiotic cell cycle (GO:0051446)2.12539939
114regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.11598730
115somite rostral/caudal axis specification (GO:0032525)2.11166967
116regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.10965164
117layer formation in cerebral cortex (GO:0021819)2.10755122
118regulation of postsynaptic membrane potential (GO:0060078)2.10451415
119prenylation (GO:0097354)2.09889165
120protein prenylation (GO:0018342)2.09889165
121fibroblast migration (GO:0010761)2.09621338
122neuron cell-cell adhesion (GO:0007158)2.09112774
123mitotic metaphase plate congression (GO:0007080)2.08865107
124regulation of synaptic transmission, glutamatergic (GO:0051966)2.08807075
125regulation of pigment cell differentiation (GO:0050932)2.08531426
126gamma-aminobutyric acid signaling pathway (GO:0007214)2.08221934
127membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.08046526
128suckling behavior (GO:0001967)2.07607838
129long-term synaptic potentiation (GO:0060291)2.07600141
130long term synaptic depression (GO:0060292)2.07196993
131regulation of type B pancreatic cell apoptotic process (GO:2000674)2.07086306
132embryonic axis specification (GO:0000578)2.06659474
133startle response (GO:0001964)2.06346997
134regulation of meiosis (GO:0040020)2.06207828
135protein localization to synapse (GO:0035418)2.06069057
136regulation of steroid hormone biosynthetic process (GO:0090030)2.05158645
137positive regulation of histone H3-K4 methylation (GO:0051571)2.05071306
138potassium ion import (GO:0010107)2.05014360
139regulation of neuronal synaptic plasticity (GO:0048168)2.04724216
140glycine transport (GO:0015816)2.04519443
141NLS-bearing protein import into nucleus (GO:0006607)2.04472322
142gamma-aminobutyric acid transport (GO:0015812)2.02734887
143negative regulation of activin receptor signaling pathway (GO:0032926)2.02425642
144positive regulation of muscle hypertrophy (GO:0014742)2.02268684
145positive regulation of cardiac muscle hypertrophy (GO:0010613)2.02268684
146cell communication by electrical coupling (GO:0010644)2.01907749
147regulation of female gonad development (GO:2000194)2.01840155
148nerve growth factor signaling pathway (GO:0038180)2.01240726
149negative regulation of neurotransmitter secretion (GO:0046929)2.00908504
150dendritic spine morphogenesis (GO:0060997)2.00838897
151embryonic retina morphogenesis in camera-type eye (GO:0060059)2.00653054
152regulation of calcium ion-dependent exocytosis (GO:0017158)1.99838136
153positive regulation of cardiac muscle tissue growth (GO:0055023)1.99548944
154multicellular organism reproduction (GO:0032504)1.99507734
155centriole replication (GO:0007099)1.99212509
156positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)1.98640935
157regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)1.97711179
158long-term memory (GO:0007616)1.97533133
159phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)1.97314557
160positive regulation of glycolytic process (GO:0045821)1.97070539
161cytoplasmic mRNA processing body assembly (GO:0033962)1.96763363
162membrane depolarization during action potential (GO:0086010)1.96745848
163neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)1.96511578
164regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO1.96225344
165positive regulation of sodium ion transmembrane transporter activity (GO:2000651)1.96182009
166microtubule anchoring (GO:0034453)1.95916063
167positive regulation of cardiac muscle tissue development (GO:0055025)1.95518807
168positive regulation of potassium ion transport (GO:0043268)1.95260938
169keratinocyte development (GO:0003334)1.95206452
170face morphogenesis (GO:0060325)1.95107783
171nucleus localization (GO:0051647)1.94114122
172regulation of long-term neuronal synaptic plasticity (GO:0048169)1.94018210
173positive regulation of cardiac muscle cell proliferation (GO:0060045)1.93510304
174calcium ion import (GO:0070509)1.93112602
175embryonic pattern specification (GO:0009880)1.93042477
176cytoskeletal anchoring at plasma membrane (GO:0007016)1.93008589
177cytoskeleton-dependent cytokinesis (GO:0061640)1.92225928
178regulation of centrosome cycle (GO:0046605)1.92188484
179neuron recognition (GO:0008038)1.91995415
180regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)1.91710815
181phospholipid homeostasis (GO:0055091)1.91451676
182regulation of vesicle fusion (GO:0031338)1.91376506
183positive regulation of synaptic transmission, glutamatergic (GO:0051968)1.90344648
184organelle transport along microtubule (GO:0072384)1.89509710
185exploration behavior (GO:0035640)1.87829619
186ER overload response (GO:0006983)1.87649537
187membrane repolarization during action potential (GO:0086011)1.87630074
188negative regulation of macrophage derived foam cell differentiation (GO:0010745)1.87400072

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.25736135
2SALL1_21062744_ChIP-ChIP_HESCs_Human2.97884677
3EZH2_22144423_ChIP-Seq_EOC_Human2.96846833
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.04508982
5CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.98033945
6ZNF217_24962896_ChIP-Seq_MCF-7_Human1.91951303
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.88254834
8SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.87083109
9SMAD_19615063_ChIP-ChIP_OVARY_Human1.85814972
10DROSHA_22980978_ChIP-Seq_HELA_Human1.84586359
11PIAS1_25552417_ChIP-Seq_VCAP_Human1.83840690
12* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.81019676
13FLI1_27457419_Chip-Seq_LIVER_Mouse1.79799476
14EWS_26573619_Chip-Seq_HEK293_Human1.79444083
15SMAD4_21799915_ChIP-Seq_A2780_Human1.77689997
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.76411582
17CDX2_19796622_ChIP-Seq_MESCs_Mouse1.74721028
18POU3F2_20337985_ChIP-ChIP_501MEL_Human1.73344079
19AR_21572438_ChIP-Seq_LNCaP_Human1.66670139
20SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.66030931
21MTF2_20144788_ChIP-Seq_MESCs_Mouse1.63786987
22TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.61069100
23EZH2_18974828_ChIP-Seq_MESCs_Mouse1.60346046
24RNF2_18974828_ChIP-Seq_MESCs_Mouse1.60346046
25* STAT3_23295773_ChIP-Seq_U87_Human1.60265064
26PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.59041984
27SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.59015965
28SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.57706609
29GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.57558069
30AR_21909140_ChIP-Seq_LNCAP_Human1.56018118
31JARID2_20064375_ChIP-Seq_MESCs_Mouse1.55590806
32TP53_16413492_ChIP-PET_HCT116_Human1.54124519
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.54000579
34ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.53840372
35KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.53693227
36PCGF2_27294783_Chip-Seq_ESCs_Mouse1.53180033
37SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.52572921
38CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.50186616
39SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.48881078
40ZFP57_27257070_Chip-Seq_ESCs_Mouse1.48011407
41TAF15_26573619_Chip-Seq_HEK293_Human1.45145829
42BRD4_25478319_ChIP-Seq_HGPS_Human1.44214411
43AHR_22903824_ChIP-Seq_MCF-7_Human1.43503975
44ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.43220512
45OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41441599
46ARNT_22903824_ChIP-Seq_MCF-7_Human1.41354121
47P300_19829295_ChIP-Seq_ESCs_Human1.39561475
48EZH2_27294783_Chip-Seq_NPCs_Mouse1.38909704
49SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38689811
50EED_16625203_ChIP-ChIP_MESCs_Mouse1.37825193
51SUZ12_27294783_Chip-Seq_NPCs_Mouse1.36591886
52NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.35133192
53NRF2_20460467_ChIP-Seq_MEFs_Mouse1.35133192
54JARID2_20075857_ChIP-Seq_MESCs_Mouse1.34486751
55SOX2_21211035_ChIP-Seq_LN229_Gbm1.34107051
56SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34016771
57RNF2_27304074_Chip-Seq_ESCs_Mouse1.31761439
58CTBP1_25329375_ChIP-Seq_LNCAP_Human1.31465395
59VDR_22108803_ChIP-Seq_LS180_Human1.31060871
60* TCF4_23295773_ChIP-Seq_U87_Human1.30962873
61CDX2_22108803_ChIP-Seq_LS180_Human1.30461826
62WT1_19549856_ChIP-ChIP_CCG9911_Human1.30429235
63REST_21632747_ChIP-Seq_MESCs_Mouse1.30334111
64EZH2_27304074_Chip-Seq_ESCs_Mouse1.29785490
65NR3C1_23031785_ChIP-Seq_PC12_Mouse1.28974264
66CBP_20019798_ChIP-Seq_JUKART_Human1.28204073
67IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.28204073
68HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.28051247
69AR_25329375_ChIP-Seq_VCAP_Human1.27776404
70SMAD3_21741376_ChIP-Seq_EPCs_Human1.27175521
71MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.26129375
72BCAT_22108803_ChIP-Seq_LS180_Human1.25456436
73NR3C1_21868756_ChIP-Seq_MCF10A_Human1.25275958
74IGF1R_20145208_ChIP-Seq_DFB_Human1.24863501
75TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24621205
76RARB_27405468_Chip-Seq_BRAIN_Mouse1.24282630
77NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.24228102
78ESR1_20079471_ChIP-ChIP_T-47D_Human1.23840476
79EP300_21415370_ChIP-Seq_HL-1_Mouse1.23590497
80RBPJ_22232070_ChIP-Seq_NCS_Mouse1.23013087
81STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.22998779
82BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.22273265
83PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.21309062
84FOXM1_23109430_ChIP-Seq_U2OS_Human1.20974084
85RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.20831807
86TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.19246773
87RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18772152
88TCF4_22108803_ChIP-Seq_LS180_Human1.18300147
89WT1_25993318_ChIP-Seq_PODOCYTE_Human1.17245773
90CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.16485621
91AR_19668381_ChIP-Seq_PC3_Human1.16394063
92FOXA2_19822575_ChIP-Seq_HepG2_Human1.15910768
93TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.15184154
94VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.14407575
95NFE2_27457419_Chip-Seq_LIVER_Mouse1.14209707
96EZH2_27294783_Chip-Seq_ESCs_Mouse1.14037976
97NANOG_18555785_Chip-Seq_ESCs_Mouse1.13821538
98P53_22387025_ChIP-Seq_ESCs_Mouse1.13721222
99TP53_18474530_ChIP-ChIP_U2OS_Human1.12859398
100FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.12841496
101PCGF2_27294783_Chip-Seq_NPCs_Mouse1.12168454
102RXR_22108803_ChIP-Seq_LS180_Human1.11465614
103SUZ12_27294783_Chip-Seq_ESCs_Mouse1.11363549
104TCF4_18268006_ChIP-ChIP_LS174T_Human1.10751743
105TP63_23658742_ChIP-Seq_EP156T_Human1.10391971
106SUZ12_18555785_Chip-Seq_ESCs_Mouse1.10364324
107FOXO3_23340844_ChIP-Seq_DLD1_Human1.10009322
108CTNNB1_20460455_ChIP-Seq_HCT116_Human1.09981228
109SMAD4_21741376_ChIP-Seq_EPCs_Human1.08749891
110CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08556683
111TRIM28_21343339_ChIP-Seq_HEK293_Human1.07843082
112SALL4_18804426_ChIP-ChIP_XEN_Mouse1.07143990
113CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.06874921
114FUS_26573619_Chip-Seq_HEK293_Human1.06142901
115RUNX2_22187159_ChIP-Seq_PCA_Human1.05521487
116YAP1_20516196_ChIP-Seq_MESCs_Mouse1.05251030
117BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.04368302
118TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.04185983
119ER_23166858_ChIP-Seq_MCF-7_Human1.03772263
120TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03064676
121ZNF274_21170338_ChIP-Seq_K562_Hela1.02085564
122UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.00758554
123E2F1_18555785_Chip-Seq_ESCs_Mouse1.00532546
124FOXM1_26456572_ChIP-Seq_MCF-7_Human1.00267526
125TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.99841695
126LXR_22158963_ChIP-Seq_LIVER_Mouse0.99657562
127TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99424070
128POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.99424070
129SMAD3_21741376_ChIP-Seq_HESCs_Human0.98897625
130SMAD4_21741376_ChIP-Seq_HESCs_Human0.98496221
131* TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.98272242
132EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.98100761
133ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.98080555
134* RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.96819731
135CMYC_18555785_Chip-Seq_ESCs_Mouse0.96082360
136TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95240528
137CJUN_26792858_Chip-Seq_BT549_Human0.94225571

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity3.77378690
2MP0009780_abnormal_chondrocyte_physiolo3.58243418
3MP0008057_abnormal_DNA_replication3.36572924
4MP0004270_analgesia2.79471609
5MP0003941_abnormal_skin_development2.70886088
6MP0003890_abnormal_embryonic-extraembry2.63765724
7MP0010352_gastrointestinal_tract_polyps2.61102877
8MP0003635_abnormal_synaptic_transmissio2.44170483
9MP0008877_abnormal_DNA_methylation2.26472030
10MP0000013_abnormal_adipose_tissue2.21877664
11MP0002909_abnormal_adrenal_gland2.14472399
12MP0003718_maternal_effect2.08383722
13MP0010678_abnormal_skin_adnexa2.00760193
14MP0010386_abnormal_urinary_bladder1.97060865
15* MP0002063_abnormal_learning/memory/cond1.92797456
16* MP0009745_abnormal_behavioral_response1.90787497
17MP0003045_fibrosis1.90530544
18MP0003880_abnormal_central_pattern1.88041439
19MP0005275_abnormal_skin_tensile1.85719963
20MP0003252_abnormal_bile_duct1.84433105
21MP0009046_muscle_twitch1.84003131
22MP0003787_abnormal_imprinting1.83401250
23MP0001299_abnormal_eye_distance/1.81864705
24MP0000569_abnormal_digit_pigmentation1.81829622
25MP0002822_catalepsy1.80926902
26MP0001486_abnormal_startle_reflex1.78860257
27MP0005551_abnormal_eye_electrophysiolog1.74115319
28MP0004043_abnormal_pH_regulation1.73712019
29MP0002064_seizures1.71667042
30MP0005365_abnormal_bile_salt1.69796626
31MP0005646_abnormal_pituitary_gland1.69750489
32MP0002734_abnormal_mechanical_nocicepti1.68042931
33MP0010234_abnormal_vibrissa_follicle1.67826006
34MP0005360_urolithiasis1.67315602
35MP0002877_abnormal_melanocyte_morpholog1.64409260
36MP0006054_spinal_hemorrhage1.64337715
37MP0010368_abnormal_lymphatic_system1.62458002
38MP0002837_dystrophic_cardiac_calcinosis1.61962523
39* MP0002572_abnormal_emotion/affect_behav1.61214108
40MP0005503_abnormal_tendon_morphology1.58310882
41MP0003690_abnormal_glial_cell1.57662154
42MP0003183_abnormal_peptide_metabolism1.53892130
43MP0005409_darkened_coat_color1.52208634
44MP0002139_abnormal_hepatobiliary_system1.51654514
45* MP0002272_abnormal_nervous_system1.51633873
46MP0002876_abnormal_thyroid_physiology1.50712424
47* MP0000427_abnormal_hair_cycle1.50116951
48MP0000383_abnormal_hair_follicle1.46660064
49MP0003937_abnormal_limbs/digits/tail_de1.46315814
50MP0004130_abnormal_muscle_cell1.39385977
51MP0005085_abnormal_gallbladder_physiolo1.38749459
52MP0000003_abnormal_adipose_tissue1.36649982
53MP0003283_abnormal_digestive_organ1.36553494
54MP0001501_abnormal_sleep_pattern1.36189591
55MP0004084_abnormal_cardiac_muscle1.35383356
56MP0005395_other_phenotype1.35037354
57MP0001177_atelectasis1.27997329
58MP0004145_abnormal_muscle_electrophysio1.27109576
59MP0002067_abnormal_sensory_capabilities1.25556659
60MP0008438_abnormal_cutaneous_collagen1.25014780
61MP0004272_abnormal_basement_membrane1.24475164
62MP0003195_calcinosis1.23791678
63MP0003868_abnormal_feces_composition1.21068750
64MP0009697_abnormal_copulation1.21053599
65MP0003329_amyloid_beta_deposits1.16467065
66MP0005171_absent_coat_pigmentation1.16005856
67MP0004885_abnormal_endolymph1.15595461
68MP0004185_abnormal_adipocyte_glucose1.15571467
69MP0003300_gastrointestinal_ulcer1.15565434
70* MP0001502_abnormal_circadian_rhythm1.13856478
71MP0001968_abnormal_touch/_nociception1.13436443
72MP0002108_abnormal_muscle_morphology1.13355498
73MP0002160_abnormal_reproductive_system1.13020890
74MP0003633_abnormal_nervous_system1.11950746
75MP0005248_abnormal_Harderian_gland1.11460076
76* MP0002078_abnormal_glucose_homeostasis1.10797900
77MP0003935_abnormal_craniofacial_develop1.10395788
78MP0005187_abnormal_penis_morphology1.10371195
79MP0008569_lethality_at_weaning1.08502477
80MP0000762_abnormal_tongue_morphology1.06299647
81MP0002229_neurodegeneration1.06151052
82MP0001440_abnormal_grooming_behavior1.05741956
83MP0002090_abnormal_vision1.05603582
84MP0002233_abnormal_nose_morphology1.03907410
85MP0002693_abnormal_pancreas_physiology1.03692341
86MP0001944_abnormal_pancreas_morphology1.03676058
87MP0003755_abnormal_palate_morphology1.03436839
88MP0000749_muscle_degeneration1.02548215
89* MP0004924_abnormal_behavior1.00695321
90* MP0005386_behavior/neurological_phenoty1.00695321
91MP0003950_abnormal_plasma_membrane1.00233047
92MP0003879_abnormal_hair_cell0.99948440
93MP0003631_nervous_system_phenotype0.99929371
94MP0010307_abnormal_tumor_latency0.99823416
95MP0003632_abnormal_nervous_system0.99639681
96* MP0005535_abnormal_body_temperature0.99356350
97MP0010329_abnormal_lipoprotein_level0.98670513
98MP0005375_adipose_tissue_phenotype0.96403720
99MP0008961_abnormal_basal_metabolism0.95475154
100MP0004036_abnormal_muscle_relaxation0.94998813
101MP0001879_abnormal_lymphatic_vessel0.94509535
102MP0005666_abnormal_adipose_tissue0.94341710
103MP0001984_abnormal_olfaction0.94320692
104MP0002557_abnormal_social/conspecific_i0.93394064
105MP0002733_abnormal_thermal_nociception0.93309622
106MP0000920_abnormal_myelination0.92486224
107MP0000647_abnormal_sebaceous_gland0.92265886
108MP0002084_abnormal_developmental_patter0.91575911
109MP0000428_abnormal_craniofacial_morphol0.91314395
110MP0003705_abnormal_hypodermis_morpholog0.90963064
111MP0005623_abnormal_meninges_morphology0.89945679
112MP0002168_other_aberrant_phenotype0.89717787
113MP0005645_abnormal_hypothalamus_physiol0.88220184
114MP0002896_abnormal_bone_mineralization0.88206229
115MP0000778_abnormal_nervous_system0.87616894
116MP0002009_preneoplasia0.87376016
117MP0008775_abnormal_heart_ventricle0.86781603
118MP0002234_abnormal_pharynx_morphology0.86355538
119MP0002060_abnormal_skin_morphology0.84880756
120MP0001970_abnormal_pain_threshold0.84537185
121MP0004215_abnormal_myocardial_fiber0.84412463
122* MP0002118_abnormal_lipid_homeostasis0.83956911
123MP0006072_abnormal_retinal_apoptosis0.83767624
124* MP0002882_abnormal_neuron_morphology0.82798389
125MP0004134_abnormal_chest_morphology0.81967872
126MP0009250_abnormal_appendicular_skeleto0.81895881
127MP0000432_abnormal_head_morphology0.81885492
128MP0002971_abnormal_brown_adipose0.81613975
129MP0005253_abnormal_eye_physiology0.81503408
130MP0002735_abnormal_chemical_nociception0.80850068
131MP0000751_myopathy0.80245758
132MP0003091_abnormal_cell_migration0.80186126
133MP0004484_altered_response_of0.80102413
134MP0001765_abnormal_ion_homeostasis0.80034407
135MP0003119_abnormal_digestive_system0.79956391
136* MP0002066_abnormal_motor_capabilities/c0.79337587
137MP0005174_abnormal_tail_pigmentation0.78629665
138MP0005670_abnormal_white_adipose0.78463993
139MP0000733_abnormal_muscle_development0.78193220
140MP0002177_abnormal_outer_ear0.77402933
141MP0000462_abnormal_digestive_system0.76992384
142MP0002295_abnormal_pulmonary_circulatio0.75762186
143MP0002269_muscular_atrophy0.75239150
144MP0003385_abnormal_body_wall0.74691190
145MP0010030_abnormal_orbit_morphology0.73534707
146MP0001929_abnormal_gametogenesis0.72618934
147MP0002102_abnormal_ear_morphology0.72294853
148MP0008058_abnormal_DNA_repair0.71809660
149MP0005620_abnormal_muscle_contractility0.70904562
150* MP0004085_abnormal_heartbeat0.70571243
151MP0003121_genomic_imprinting0.70355167
152MP0005367_renal/urinary_system_phenotyp0.69404708
153MP0000516_abnormal_urinary_system0.69404708
154MP0005380_embryogenesis_phenotype0.69300929
155MP0001672_abnormal_embryogenesis/_devel0.69300929
156MP0010094_abnormal_chromosome_stability0.68656469
157MP0004233_abnormal_muscle_weight0.67785957
158MP0001286_abnormal_eye_development0.66451325
159MP0000631_abnormal_neuroendocrine_gland0.64927914
160MP0004197_abnormal_fetal_growth/weight/0.64305118
161MP0001293_anophthalmia0.64063151
162MP0009703_decreased_birth_body0.64034155
163MP0002938_white_spotting0.63175931
164MP0002088_abnormal_embryonic_growth/wei0.62992240

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.04026471
2Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.42551520
3Action tremor (HP:0002345)3.14837867
4Volvulus (HP:0002580)3.02653664
5Focal seizures (HP:0007359)2.88334217
6Febrile seizures (HP:0002373)2.86365775
7Hyperinsulinemic hypoglycemia (HP:0000825)2.83250339
8Progressive cerebellar ataxia (HP:0002073)2.71117014
9Hypoglycemic seizures (HP:0002173)2.70572762
10Macroorchidism (HP:0000053)2.69140226
11Fair hair (HP:0002286)2.67772576
12Atonic seizures (HP:0010819)2.66174636
13Hypoplastic labia majora (HP:0000059)2.65635794
14Pigmentary retinal degeneration (HP:0001146)2.57678909
15Hyperglycemia (HP:0003074)2.56806572
16Blue irides (HP:0000635)2.55771389
17Epileptic encephalopathy (HP:0200134)2.54113841
18Insulin-resistant diabetes mellitus (HP:0000831)2.47533099
19Abnormality of the labia majora (HP:0012881)2.46271710
20Symptomatic seizures (HP:0011145)2.45064772
21Central scotoma (HP:0000603)2.40430251
22Excessive salivation (HP:0003781)2.39277604
23Drooling (HP:0002307)2.39277604
24Visual hallucinations (HP:0002367)2.39217630
25Lip pit (HP:0100267)2.39193520
26Absence seizures (HP:0002121)2.39100132
27Enlarged penis (HP:0000040)2.37516436
28Insidious onset (HP:0003587)2.37124505
29Termporal pattern (HP:0011008)2.37124505
30Bundle branch block (HP:0011710)2.36730072
31Generalized tonic-clonic seizures (HP:0002069)2.36571582
32Right ventricular cardiomyopathy (HP:0011663)2.35993636
33Papillary thyroid carcinoma (HP:0002895)2.33772840
34Bifid tongue (HP:0010297)2.31762704
35Dysdiadochokinesis (HP:0002075)2.29951954
36Hyperventilation (HP:0002883)2.28542490
37Hypoplastic ischia (HP:0003175)2.26353755
38Genetic anticipation (HP:0003743)2.26283941
39Oligodactyly (hands) (HP:0001180)2.25990299
40Epileptiform EEG discharges (HP:0011182)2.24545460
41Cardiovascular calcification (HP:0011915)2.22048988
42Abnormality of the ischium (HP:0003174)2.19755100
43Scanning speech (HP:0002168)2.19315068
44Astrocytoma (HP:0009592)2.18858919
45Abnormality of the astrocytes (HP:0100707)2.18858919
46Gaze-evoked nystagmus (HP:0000640)2.17724898
47Thyroid carcinoma (HP:0002890)2.16762537
48Biliary tract neoplasm (HP:0100574)2.15943950
49EEG with generalized epileptiform discharges (HP:0011198)2.15781517
50Dysmetric saccades (HP:0000641)2.11620325
51Hyperkalemia (HP:0002153)2.09316239
52Dysmetria (HP:0001310)2.07575343
53Ketoacidosis (HP:0001993)2.06172781
54Abnormal biliary tract morphology (HP:0012440)2.05699986
55Decreased circulating renin level (HP:0003351)2.05038939
56Truncal ataxia (HP:0002078)2.04095720
57Chromsome breakage (HP:0040012)2.03057976
58Vascular calcification (HP:0004934)2.01721295
59Intention tremor (HP:0002080)2.01587645
60Urinary bladder sphincter dysfunction (HP:0002839)2.01587233
61Absent speech (HP:0001344)2.00708659
62Hypsarrhythmia (HP:0002521)2.00361460
63Sensory axonal neuropathy (HP:0003390)1.99660742
64Dialeptic seizures (HP:0011146)1.99659089
65Myokymia (HP:0002411)1.98469179
66Glioma (HP:0009733)1.97300822
67Skin nodule (HP:0200036)1.95045902
68Hypoglycemic coma (HP:0001325)1.94578111
69Cystic hygroma (HP:0000476)1.91705658
70Epidermoid cyst (HP:0200040)1.91494870
71Postural instability (HP:0002172)1.90527703
72Retinal atrophy (HP:0001105)1.88115028
73Urethral obstruction (HP:0000796)1.88008411
74Abnormality of calcium-phosphate metabolism (HP:0100530)1.87820804
75Agitation (HP:0000713)1.87117629
76Impaired vibration sensation in the lower limbs (HP:0002166)1.87098365
77Metaphyseal dysplasia (HP:0100255)1.85091880
78Aplasia/Hypoplasia of the tibia (HP:0005772)1.84607569
79Abnormal auditory evoked potentials (HP:0006958)1.84408818
80Increased number of teeth (HP:0011069)1.83638994
81Abnormality of chromosome stability (HP:0003220)1.81208633
82Microglossia (HP:0000171)1.80864631
83Conjugated hyperbilirubinemia (HP:0002908)1.80307210
84Resting tremor (HP:0002322)1.78088841
85Aplasia/Hypoplasia of the tongue (HP:0010295)1.75703799
86Limited hip movement (HP:0008800)1.75494009
87Broad-based gait (HP:0002136)1.75410386
88Rhabdomyosarcoma (HP:0002859)1.75284763
89Subacute progressive viral hepatitis (HP:0006572)1.75104485
90Abnormality of abdominal situs (HP:0011620)1.75082654
91Abdominal situs inversus (HP:0003363)1.75082654
92Labial hypoplasia (HP:0000066)1.74415694
93Absent frontal sinuses (HP:0002688)1.74385051
94Neoplasm of the small intestine (HP:0100833)1.73696819
95Pheochromocytoma (HP:0002666)1.72387489
96Popliteal pterygium (HP:0009756)1.72204938
97Depression (HP:0000716)1.71931290
98Knee flexion contracture (HP:0006380)1.71651556
99Intrahepatic cholestasis (HP:0001406)1.71524741
100Generalized hypopigmentation of hair (HP:0011358)1.70784363
101Aplasia involving bones of the extremities (HP:0009825)1.70695273
102Aplasia involving bones of the upper limbs (HP:0009823)1.70695273
103Aplasia of the phalanges of the hand (HP:0009802)1.70695273
104Calf muscle hypertrophy (HP:0008981)1.70556998
105Complement deficiency (HP:0004431)1.70307916
106Syncope (HP:0001279)1.69379543
107Onion bulb formation (HP:0003383)1.69307640
108Cubitus valgus (HP:0002967)1.69042501
109Prolonged QT interval (HP:0001657)1.68170812
110Abnormal social behavior (HP:0012433)1.67842870
111Impaired social interactions (HP:0000735)1.67842870
112Abnormality of the calf musculature (HP:0001430)1.66940203
113Arterial tortuosity (HP:0005116)1.65306267
114Capillary hemangiomas (HP:0005306)1.65001632
115Abnormal pancreas size (HP:0012094)1.64986516
116Increased circulating renin level (HP:0000848)1.64668099
117Truncal obesity (HP:0001956)1.64214731
118Turricephaly (HP:0000262)1.63170349
119Double outlet right ventricle (HP:0001719)1.62271253
120Congenital malformation of the right heart (HP:0011723)1.62271253
121Impaired smooth pursuit (HP:0007772)1.62099546
122Abnormality of the nasal septum (HP:0000419)1.61528264
123Hypoplastic female external genitalia (HP:0012815)1.61079842
124Abnormality of salivation (HP:0100755)1.60920764
125Chromosomal breakage induced by crosslinking agents (HP:0003221)1.60755067
126Abnormality of the corticospinal tract (HP:0002492)1.60479822
127Widely spaced teeth (HP:0000687)1.59932518
128Dyschromatopsia (HP:0007641)1.58857584
129Scotoma (HP:0000575)1.57645552
130Abnormality of the intrinsic pathway (HP:0010989)1.57459442
131Aneurysm (HP:0002617)1.57249403
132Hamartoma of the eye (HP:0010568)1.57053096
133Abnormality of potassium homeostasis (HP:0011042)1.57016297
134Median cleft lip (HP:0000161)1.56945038
135Overgrowth (HP:0001548)1.56940502
136Pulmonic stenosis (HP:0001642)1.56439049
137Heterotopia (HP:0002282)1.56246476
138Bradycardia (HP:0001662)1.56172030
139Decreased motor nerve conduction velocity (HP:0003431)1.56006366
140Short chin (HP:0000331)1.55532932
141Transitional cell carcinoma of the bladder (HP:0006740)1.54929543
142Mildly elevated creatine phosphokinase (HP:0008180)1.54807400
143Neoplasm of the oral cavity (HP:0100649)1.54735477
144Sensorimotor neuropathy (HP:0007141)1.54399949
145Degeneration of the lateral corticospinal tracts (HP:0002314)1.53548407
146Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.53548407
147Anxiety (HP:0000739)1.53437706
148Neoplasm of the adrenal cortex (HP:0100641)1.53037937
149Vascular tortuosity (HP:0004948)1.53016371
150Narrow palate (HP:0000189)1.52951100
151Follicular hyperkeratosis (HP:0007502)1.52652332
152Embryonal renal neoplasm (HP:0011794)1.52517917
153Abnormality of macular pigmentation (HP:0008002)1.52175524
154Chorioretinal atrophy (HP:0000533)1.52113895
155Impaired vibratory sensation (HP:0002495)1.51531158
156Aqueductal stenosis (HP:0002410)1.51528112
157Curly hair (HP:0002212)1.51433495
158Bladder carcinoma (HP:0002862)1.51290338
159Bladder neoplasm (HP:0009725)1.51290338
160Congenital stationary night blindness (HP:0007642)1.51107271
161Menstrual irregularities (HP:0000858)1.50166532
162Deep philtrum (HP:0002002)1.48283563
163Abnormality of the frontal sinuses (HP:0002687)1.46827858
164Hyperphosphatemia (HP:0002905)1.46664298
165Protruding tongue (HP:0010808)1.46553467
166Muscle hypertrophy of the lower extremities (HP:0008968)1.45783804
167Aplasia/Hypoplasia of the scapulae (HP:0006713)1.45560787
168Hypoplastic scapulae (HP:0000882)1.45560787
169Nephroblastoma (Wilms tumor) (HP:0002667)1.45287985
170Hip contracture (HP:0003273)1.45215129
171Wrist flexion contracture (HP:0001239)1.44852014
172Short tibia (HP:0005736)1.43918378
173Aortic dissection (HP:0002647)1.42736911
174Supernumerary spleens (HP:0009799)1.41303421
175Abnormality of the labia (HP:0000058)1.41201682
176Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.40931328
177Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.40433257
178Cone-rod dystrophy (HP:0000548)1.40288993

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS13.16360138
2NTRK33.13853225
3PRPF4B3.07406317
4INSRR3.05269691
5ACVR1B2.62221667
6FRK2.61819764
7TRIM282.39007321
8MAP3K42.13949007
9BMPR1B2.04994530
10EPHA41.92796287
11EIF2AK31.88969270
12MST41.88470004
13MST1R1.82309500
14MAP3K21.80166755
15PNCK1.74609831
16MAP3K91.64205278
17CAMK1G1.61831774
18STK381.60879073
19BRSK21.60793502
20PRKD31.57460233
21BRD41.54836070
22CASK1.54618848
23CAMK1D1.52590260
24MKNK21.52297702
25SGK21.49762011
26PBK1.46700825
27SGK4941.44399557
28SGK2231.44399557
29PAK61.43993008
30FER1.43506291
31DAPK21.40846589
32AKT31.40666121
33SGK31.39281198
34MELK1.33476295
35WNK11.31255728
36MAP3K121.29838543
37MAP2K71.28710927
38DMPK1.26260268
39FGFR21.24982180
40TAOK31.24727920
41CAMKK11.23204167
42TTK1.22522252
43NTRK11.22337625
44MAP2K41.21433140
45TRPM71.18507431
46OBSCN1.18487159
47MYLK1.16281938
48PRKCH1.16043140
49KSR21.11404207
50PAK31.10993041
51CAMKK21.08332219
52RET1.07851156
53SCYL21.07562150
54STK391.07169017
55STK38L1.05818198
56ERBB41.01618525
57WNK31.01298178
58STK241.01282755
59NLK1.00703070
60WNK40.99969613
61PDGFRA0.99169951
62WEE10.98845508
63NUAK10.98811904
64RIPK10.93840782
65PLK30.93711311
66TGFBR10.92621934
67KSR10.92456772
68PIK3CA0.91832713
69SGK10.91722214
70NEK90.90161453
71PDGFRB0.89517475
72OXSR10.87880133
73NTRK20.87006559
74CDC42BPA0.86220507
75NEK60.85253524
76* CDK50.84049347
77CAMK2A0.82487095
78FGFR10.81058471
79JAK10.80546090
80DDR20.78518103
81FGFR30.78062742
82HIPK20.77089980
83CAMK2D0.74525841
84EIF2AK10.73360305
85CDK120.72083820
86LATS20.71697254
87PRKAA10.71049363
88PLK20.70973711
89STK30.70796045
90EPHB10.70063759
91PDPK10.69563315
92MINK10.69346925
93PRKCE0.69011855
94PLK10.68171515
95EPHA30.67612948
96MARK10.67181083
97TAF10.65901786
98MAP3K130.65393456
99MET0.64031861
100PTK20.63626565
101CAMK2B0.63463247
102PDK10.62901825
103ROCK10.61977218
104STK110.61891063
105MAP3K60.61883311
106MAP3K10.60075064
107ATM0.59889790
108RIPK40.57946249
109SIK10.57496305
110MAPK100.56390815
111PRKAA20.55945063
112MAP3K70.55865076
113CSNK1G10.55438311
114PKN10.55183636
115RPS6KA30.54343038
116NEK10.54116819
117LMTK20.53740531
118BCR0.53376179
119CDK90.52569003
120GRK50.51827605
121BMPR20.51626329
122PTK60.51322046
123MAPK130.50687141
124EPHA20.49312701
125BRSK10.49311884
126BUB10.49230991
127PHKG10.49141814
128PHKG20.49141814
129CSNK1A1L0.48637484
130PINK10.48124357
131ERBB30.47390631
132EIF2AK20.47241742
133PRKCG0.46586599
134GSK3A0.46463351
135MAP4K20.46277728
136CSNK1G20.45805823
137MAPK150.45718491
138TNIK0.45331301
139PTK2B0.45019139
140YES10.44798112
141MKNK10.39073854
142GRK10.38403169
143MTOR0.38076987
144CHEK10.37613803
145PRKCI0.37425972

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.04438943
2Nicotine addiction_Homo sapiens_hsa050331.95664568
3Insulin secretion_Homo sapiens_hsa049111.92204371
4TGF-beta signaling pathway_Homo sapiens_hsa043501.82769346
5Type II diabetes mellitus_Homo sapiens_hsa049301.80437487
6Circadian entrainment_Homo sapiens_hsa047131.73942224
7Maturity onset diabetes of the young_Homo sapiens_hsa049501.67242702
8Basal transcription factors_Homo sapiens_hsa030221.66181865
9Non-homologous end-joining_Homo sapiens_hsa034501.65150083
10GABAergic synapse_Homo sapiens_hsa047271.64172373
11Hippo signaling pathway_Homo sapiens_hsa043901.63453736
12Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.62880716
13Glutamatergic synapse_Homo sapiens_hsa047241.62362856
14Long-term potentiation_Homo sapiens_hsa047201.60275305
15Amphetamine addiction_Homo sapiens_hsa050311.58629973
16Oocyte meiosis_Homo sapiens_hsa041141.57770280
17Synaptic vesicle cycle_Homo sapiens_hsa047211.55711344
18Vitamin B6 metabolism_Homo sapiens_hsa007501.48951656
19Tight junction_Homo sapiens_hsa045301.47294258
20Morphine addiction_Homo sapiens_hsa050321.46428100
21Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.44165593
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.40253596
23Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.37262751
24Renin secretion_Homo sapiens_hsa049241.36204244
25Salivary secretion_Homo sapiens_hsa049701.36134566
26Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.35953576
27Taste transduction_Homo sapiens_hsa047421.33670169
28Phototransduction_Homo sapiens_hsa047441.33280732
29Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.32970256
30Cocaine addiction_Homo sapiens_hsa050301.30596446
31Cell cycle_Homo sapiens_hsa041101.29061288
32Cholinergic synapse_Homo sapiens_hsa047251.26024064
33* Dopaminergic synapse_Homo sapiens_hsa047281.20751033
34Selenocompound metabolism_Homo sapiens_hsa004501.20547256
35Olfactory transduction_Homo sapiens_hsa047401.20544037
36Caffeine metabolism_Homo sapiens_hsa002321.19170900
37Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.18032550
38Gastric acid secretion_Homo sapiens_hsa049711.13517889
39Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.12060374
40Wnt signaling pathway_Homo sapiens_hsa043101.11355770
41Long-term depression_Homo sapiens_hsa047301.10813348
42Phosphatidylinositol signaling system_Homo sapiens_hsa040701.10384817
43Dorso-ventral axis formation_Homo sapiens_hsa043201.09210624
44cAMP signaling pathway_Homo sapiens_hsa040241.08240827
45Hedgehog signaling pathway_Homo sapiens_hsa043401.08126310
46Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.07098748
47Proteoglycans in cancer_Homo sapiens_hsa052051.06589595
48Oxytocin signaling pathway_Homo sapiens_hsa049211.06508145
49Serotonergic synapse_Homo sapiens_hsa047261.05158063
50GnRH signaling pathway_Homo sapiens_hsa049121.04929521
51RNA degradation_Homo sapiens_hsa030181.04468592
52Protein export_Homo sapiens_hsa030601.04274562
53Sulfur metabolism_Homo sapiens_hsa009201.02957873
54Pancreatic secretion_Homo sapiens_hsa049721.02950959
55Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.01101497
56Carbohydrate digestion and absorption_Homo sapiens_hsa049731.00818923
57Thyroid hormone synthesis_Homo sapiens_hsa049181.00764669
58Ovarian steroidogenesis_Homo sapiens_hsa049130.99824159
59cGMP-PKG signaling pathway_Homo sapiens_hsa040220.98901394
60Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.97840216
61Fanconi anemia pathway_Homo sapiens_hsa034600.97509387
62MicroRNAs in cancer_Homo sapiens_hsa052060.95817600
63Thyroid cancer_Homo sapiens_hsa052160.95373939
64Melanoma_Homo sapiens_hsa052180.94786932
65Sphingolipid metabolism_Homo sapiens_hsa006000.93966918
66Dilated cardiomyopathy_Homo sapiens_hsa054140.93005589
67Bile secretion_Homo sapiens_hsa049760.91990688
68Vascular smooth muscle contraction_Homo sapiens_hsa042700.91475388
69Calcium signaling pathway_Homo sapiens_hsa040200.91016417
70Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.90091653
71Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.89518574
72p53 signaling pathway_Homo sapiens_hsa041150.88991900
73Estrogen signaling pathway_Homo sapiens_hsa049150.86292175
74Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.84527147
75Arginine biosynthesis_Homo sapiens_hsa002200.84014051
76Butanoate metabolism_Homo sapiens_hsa006500.81824155
77ABC transporters_Homo sapiens_hsa020100.81334707
78FoxO signaling pathway_Homo sapiens_hsa040680.78917016
79Primary bile acid biosynthesis_Homo sapiens_hsa001200.78003184
80ErbB signaling pathway_Homo sapiens_hsa040120.77551298
81Cysteine and methionine metabolism_Homo sapiens_hsa002700.77375282
82Glucagon signaling pathway_Homo sapiens_hsa049220.77137354
83Prostate cancer_Homo sapiens_hsa052150.76968325
84Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.76016295
85Glioma_Homo sapiens_hsa052140.75556867
86Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.75355910
87Basal cell carcinoma_Homo sapiens_hsa052170.74860602
88Choline metabolism in cancer_Homo sapiens_hsa052310.73545975
89PPAR signaling pathway_Homo sapiens_hsa033200.73241450
90Phospholipase D signaling pathway_Homo sapiens_hsa040720.72966149
91Inositol phosphate metabolism_Homo sapiens_hsa005620.72927437
92Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.72224863
93Gap junction_Homo sapiens_hsa045400.71376291
94Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.70722461
95Insulin resistance_Homo sapiens_hsa049310.68440116
96Endometrial cancer_Homo sapiens_hsa052130.68031369
97Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.67561052
98Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.67421015
99Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.67299567
100* Circadian rhythm_Homo sapiens_hsa047100.66787697
101Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.66169979
102Regulation of actin cytoskeleton_Homo sapiens_hsa048100.65636908
103Fatty acid biosynthesis_Homo sapiens_hsa000610.64552554
104Lysine degradation_Homo sapiens_hsa003100.64493486
105Longevity regulating pathway - mammal_Homo sapiens_hsa042110.63782063
106Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.62808973
107Axon guidance_Homo sapiens_hsa043600.62527010
108RNA transport_Homo sapiens_hsa030130.61332900
109Glycerolipid metabolism_Homo sapiens_hsa005610.61256722
110Mineral absorption_Homo sapiens_hsa049780.60940068
111Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.60578254
112PI3K-Akt signaling pathway_Homo sapiens_hsa041510.60283886
113Melanogenesis_Homo sapiens_hsa049160.59889273
114Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.59484314
115Small cell lung cancer_Homo sapiens_hsa052220.59332152
116Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.57300486
117mTOR signaling pathway_Homo sapiens_hsa041500.56932755
118beta-Alanine metabolism_Homo sapiens_hsa004100.55875953
119Vibrio cholerae infection_Homo sapiens_hsa051100.54713281
120Focal adhesion_Homo sapiens_hsa045100.54591708
121Complement and coagulation cascades_Homo sapiens_hsa046100.54125896
122Adipocytokine signaling pathway_Homo sapiens_hsa049200.52211090
123Protein digestion and absorption_Homo sapiens_hsa049740.51971678
124Tryptophan metabolism_Homo sapiens_hsa003800.50725617
125ECM-receptor interaction_Homo sapiens_hsa045120.49976256
126Fatty acid metabolism_Homo sapiens_hsa012120.49227539
127Fatty acid degradation_Homo sapiens_hsa000710.49207271
128Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49173154
129Insulin signaling pathway_Homo sapiens_hsa049100.49094796
130Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48999980
131Propanoate metabolism_Homo sapiens_hsa006400.47652219
132Ras signaling pathway_Homo sapiens_hsa040140.47309035
133Prolactin signaling pathway_Homo sapiens_hsa049170.47031858
134Collecting duct acid secretion_Homo sapiens_hsa049660.45861722
135MAPK signaling pathway_Homo sapiens_hsa040100.45814193
136Prion diseases_Homo sapiens_hsa050200.45514530
137Fat digestion and absorption_Homo sapiens_hsa049750.43709251
138Adherens junction_Homo sapiens_hsa045200.43360133
139Amoebiasis_Homo sapiens_hsa051460.42898692
140AMPK signaling pathway_Homo sapiens_hsa041520.42597255

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