CLP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the Clp1 family. The encoded protein is a multifunctional kinase which is a component of the tRNA splicing endonuclease complex and a component of the pre-mRNA cleavage complex II. This protein is implicated in tRNA, mRNA, and siRNA maturation. Mutations in this gene are associated with pontocerebellar hypoplasia type 10 (PCH10). Alternatively splice transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1purine nucleobase biosynthetic process (GO:0009113)4.31008142
2DNA replication checkpoint (GO:0000076)4.27359325
3mitotic metaphase plate congression (GO:0007080)4.20771097
4nucleobase biosynthetic process (GO:0046112)4.16746722
5DNA replication initiation (GO:0006270)4.13597669
6maturation of SSU-rRNA (GO:0030490)4.09392878
7negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.07263169
8negative regulation of ligase activity (GO:0051352)4.07263169
9DNA deamination (GO:0045006)3.95476054
10ribosome biogenesis (GO:0042254)3.92934280
11DNA strand elongation involved in DNA replication (GO:0006271)3.89721358
12telomere maintenance via semi-conservative replication (GO:0032201)3.87384099
13CENP-A containing nucleosome assembly (GO:0034080)3.80966573
14ribosomal small subunit assembly (GO:0000028)3.77702697
15establishment of integrated proviral latency (GO:0075713)3.77442790
16DNA strand elongation (GO:0022616)3.76909954
17chromatin remodeling at centromere (GO:0031055)3.68210002
18rRNA modification (GO:0000154)3.63763604
19telomere maintenance via recombination (GO:0000722)3.60332217
20ribonucleoprotein complex biogenesis (GO:0022613)3.60315520
21positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.58261289
22proteasome assembly (GO:0043248)3.57756315
23metaphase plate congression (GO:0051310)3.56030725
24establishment of protein localization to mitochondrial membrane (GO:0090151)3.54622100
25DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.54511216
26positive regulation of ligase activity (GO:0051351)3.50218014
27intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.49621745
28signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.49621745
29signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.49541284
30signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.49541284
31signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.49541284
32transcription elongation from RNA polymerase III promoter (GO:0006385)3.48571166
33termination of RNA polymerase III transcription (GO:0006386)3.48571166
34regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.46229806
35DNA replication-independent nucleosome organization (GO:0034724)3.44140786
36DNA replication-independent nucleosome assembly (GO:0006336)3.44140786
37signal transduction involved in DNA damage checkpoint (GO:0072422)3.43840740
38signal transduction involved in DNA integrity checkpoint (GO:0072401)3.43840740
39chaperone-mediated protein transport (GO:0072321)3.43835574
40formation of translation preinitiation complex (GO:0001731)3.40190172
41regulation of cellular amino acid metabolic process (GO:0006521)3.37305648
42signal transduction involved in cell cycle checkpoint (GO:0072395)3.36845389
43kinetochore organization (GO:0051383)3.35121622
44regulation of ubiquitin-protein transferase activity (GO:0051438)3.33546088
45mitotic recombination (GO:0006312)3.32093412
46rRNA processing (GO:0006364)3.31541372
47kinetochore assembly (GO:0051382)3.30930740
48maturation of 5.8S rRNA (GO:0000460)3.30135066
497-methylguanosine mRNA capping (GO:0006370)3.28797097
50establishment of viral latency (GO:0019043)3.28410333
51RNA capping (GO:0036260)3.28323105
527-methylguanosine RNA capping (GO:0009452)3.28323105
53regulation of ligase activity (GO:0051340)3.27860461
54mitotic chromosome condensation (GO:0007076)3.26809058
55protein localization to kinetochore (GO:0034501)3.25498351
56ribosomal large subunit biogenesis (GO:0042273)3.25012094
57establishment of chromosome localization (GO:0051303)3.24615613
58telomere maintenance via telomere lengthening (GO:0010833)3.22337692
59rRNA metabolic process (GO:0016072)3.22130024
60histone exchange (GO:0043486)3.20717497
61spliceosomal snRNP assembly (GO:0000387)3.20151093
62ribosome assembly (GO:0042255)3.19998581
63rRNA methylation (GO:0031167)3.18446417
64regulation of spindle organization (GO:0090224)3.16533622
65ribosomal small subunit biogenesis (GO:0042274)3.16372262
66negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.16182528
67mitotic nuclear envelope disassembly (GO:0007077)3.15667431
68negative regulation of protein ubiquitination (GO:0031397)3.15172376
69mitochondrial RNA metabolic process (GO:0000959)3.14600082
70protein targeting to mitochondrion (GO:0006626)3.11319477
71termination of RNA polymerase I transcription (GO:0006363)3.10898764
72antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.10661697
73negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.07089097
74attachment of spindle microtubules to kinetochore (GO:0008608)3.06206826
75transcription elongation from RNA polymerase I promoter (GO:0006362)3.05651771
76DNA replication-dependent nucleosome organization (GO:0034723)3.04267815
77DNA replication-dependent nucleosome assembly (GO:0006335)3.04267815
78regulation of double-strand break repair via homologous recombination (GO:0010569)3.03335396
79transcription-coupled nucleotide-excision repair (GO:0006283)3.03065978
80nucleotide-excision repair, DNA gap filling (GO:0006297)3.02218409
81regulation of nuclear cell cycle DNA replication (GO:0033262)3.00665006
82protein localization to chromosome, centromeric region (GO:0071459)2.98825489
83maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.98024292
84regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.97809826
85anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.97452232
86transcription from RNA polymerase I promoter (GO:0006360)2.97387419
87protein localization to mitochondrion (GO:0070585)2.96869747
88negative regulation of protein modification by small protein conjugation or removal (GO:1903321)2.95530757
89mitotic spindle assembly checkpoint (GO:0007094)2.94949058
90regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.94577062
91IMP biosynthetic process (GO:0006188)2.94386983
92antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.94011790
93regulation of mitochondrial translation (GO:0070129)2.93960915
94sister chromatid segregation (GO:0000819)2.92585209
95meiotic chromosome segregation (GO:0045132)2.90236928
96DNA catabolic process, exonucleolytic (GO:0000738)2.89734537
97nuclear pore organization (GO:0006999)2.88935798
98spindle assembly checkpoint (GO:0071173)2.88045779
99regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.87774083
100positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.86276147
101negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.85127962
102membrane disassembly (GO:0030397)2.84588226
103nuclear envelope disassembly (GO:0051081)2.84588226
104DNA-dependent DNA replication (GO:0006261)2.84342205
105pseudouridine synthesis (GO:0001522)2.82649173
106nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.81935271
107spindle checkpoint (GO:0031577)2.81749270
108protein K6-linked ubiquitination (GO:0085020)2.81191868
109cullin deneddylation (GO:0010388)2.80718304
110viral mRNA export from host cell nucleus (GO:0046784)2.80698546
111cell cycle G1/S phase transition (GO:0044843)2.79219556
112G1/S transition of mitotic cell cycle (GO:0000082)2.79219556
113establishment of protein localization to mitochondrion (GO:0072655)2.78930331
114negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.77434115
115transcription initiation from RNA polymerase I promoter (GO:0006361)2.74725210
116nuclear pore complex assembly (GO:0051292)2.74165006
117positive regulation of chromosome segregation (GO:0051984)2.74059224
118telomere maintenance (GO:0000723)2.73553724
119telomere organization (GO:0032200)2.73209781
120IMP metabolic process (GO:0046040)2.72887208
121cellular component biogenesis (GO:0044085)2.72513621
122folic acid metabolic process (GO:0046655)2.72337337
123histone mRNA metabolic process (GO:0008334)2.70426040
124mitotic sister chromatid segregation (GO:0000070)2.70077269
125* DNA-templated transcription, termination (GO:0006353)2.69820325
126exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.68429064
127transcription elongation from RNA polymerase II promoter (GO:0006368)2.68030950
128DNA synthesis involved in DNA repair (GO:0000731)2.67895821
129negative regulation of mitotic sister chromatid separation (GO:2000816)2.67505024
130negative regulation of mitotic sister chromatid segregation (GO:0033048)2.67505024
131negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.67505024
132negative regulation of sister chromatid segregation (GO:0033046)2.67505024
133negative regulation of chromosome segregation (GO:0051985)2.66047998
134translational termination (GO:0006415)2.65778122
135viral transcription (GO:0019083)2.65173720
136DNA-templated transcription, elongation (GO:0006354)2.64734557
137mitotic spindle checkpoint (GO:0071174)2.64129115
138regulation of chromosome segregation (GO:0051983)2.62701303
139DNA unwinding involved in DNA replication (GO:0006268)2.62554015
140regulation of mitotic metaphase/anaphase transition (GO:0030071)2.61741362

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.62755774
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.80228051
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.45818361
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.42520726
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.40987859
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.21130962
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.16661907
8* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.05873909
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.05003941
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.97701144
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.79472438
12* ETS1_20019798_ChIP-Seq_JURKAT_Human2.78226060
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.75980354
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.65736229
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.61644611
16MYC_19079543_ChIP-ChIP_MESCs_Mouse2.52544392
17VDR_23849224_ChIP-Seq_CD4+_Human2.52375276
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.46041296
19MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.34490872
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.31196504
21HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.30518981
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.28441951
23NELFA_20434984_ChIP-Seq_ESCs_Mouse2.24611520
24FOXP3_21729870_ChIP-Seq_TREG_Human2.12624021
25* XRN2_22483619_ChIP-Seq_HELA_Human2.09400450
26SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.05006832
27HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.03137494
28SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.00004802
29DCP1A_22483619_ChIP-Seq_HELA_Human1.93099963
30* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.92358328
31CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.89588234
32* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.86459405
33NOTCH1_21737748_ChIP-Seq_TLL_Human1.82125732
34FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.77939364
35ELK1_19687146_ChIP-ChIP_HELA_Human1.77755197
36PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.76669684
37GABP_19822575_ChIP-Seq_HepG2_Human1.76420922
38HOXB4_20404135_ChIP-ChIP_EML_Mouse1.76230882
39AR_21909140_ChIP-Seq_LNCAP_Human1.72985908
40SRF_21415370_ChIP-Seq_HL-1_Mouse1.71977567
41MYCN_18555785_ChIP-Seq_MESCs_Mouse1.71718964
42E2F1_21310950_ChIP-Seq_MCF-7_Human1.70077689
43POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.67943733
44TTF2_22483619_ChIP-Seq_HELA_Human1.66842534
45NANOG_18555785_ChIP-Seq_MESCs_Mouse1.65717518
46MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.64651311
47SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.59942539
48THAP11_20581084_ChIP-Seq_MESCs_Mouse1.58288289
49YY1_21170310_ChIP-Seq_MESCs_Mouse1.58025628
50FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.57584478
51* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.55135449
52KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.51427977
53IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.51278080
54EGR1_19374776_ChIP-ChIP_THP-1_Human1.45546536
55SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.44659355
56YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.41345694
57ERG_20887958_ChIP-Seq_HPC-7_Mouse1.40303756
58HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.36772329
59ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.33786195
60CIITA_25753668_ChIP-Seq_RAJI_Human1.33671530
61ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.30384109
62KDM5A_27292631_Chip-Seq_BREAST_Human1.29351744
63PADI4_21655091_ChIP-ChIP_MCF-7_Human1.26907245
64PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.26159273
65TP63_19390658_ChIP-ChIP_HaCaT_Human1.24261871
66DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.23954950
67* SPI1_23547873_ChIP-Seq_NB4_Human1.21119671
68ZFX_18555785_ChIP-Seq_MESCs_Mouse1.17159509
69IRF8_21731497_ChIP-ChIP_J774_Mouse1.14511698
70ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.12595481
71IRF8_22096565_ChIP-ChIP_GC-B_Human1.12514080
72POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.12423796
73CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.10727306
74* CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.02736340
75KAP1_22055183_ChIP-Seq_ESCs_Mouse1.02075698
76MYC_18940864_ChIP-ChIP_HL60_Human1.00932178
77STAT3_1855785_ChIP-Seq_MESCs_Mouse1.00399928
78MYC_22102868_ChIP-Seq_BL_Human1.00149286
79* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.98105884
80CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.97198437
81KLF4_18555785_ChIP-Seq_MESCs_Mouse0.96954375
82HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.95437799
83TFEB_21752829_ChIP-Seq_HELA_Human0.95165713
84BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.95071405
85STAT4_19710469_ChIP-ChIP_TH1__Mouse0.94407416
86GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.91909112
87MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.88842936
88* CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.88085300
89SOX2_18555785_ChIP-Seq_MESCs_Mouse0.86718383
90ELK1_22589737_ChIP-Seq_MCF10A_Human0.86542868
91CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.84239463
92PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.83667521
93SOX17_20123909_ChIP-Seq_XEN_Mouse0.83601704
94NANOG_16153702_ChIP-ChIP_HESCs_Human0.82614500
95SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.82326059
96* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.80419587
97HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.78218083
98MYB_21317192_ChIP-Seq_ERMYB_Mouse0.77846223
99MYB_26560356_Chip-Seq_TH1_Human0.77666159
100* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.76931406
101CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.75944258
102IRF1_19129219_ChIP-ChIP_H3396_Human0.74879827
103ELF5_23300383_ChIP-Seq_T47D_Human0.74318031
104NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.74285382
105TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.73890795
106SOX2_16153702_ChIP-ChIP_HESCs_Human0.73724896
107* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73163996
108GATA2_22383799_ChIP-Seq_G1ME_Mouse0.73111720
109MYB_26560356_Chip-Seq_TH2_Human0.72954252
110DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.72802612
111ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.72631338
112CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.72504567
113* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.72375052

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.10902526
2MP0010094_abnormal_chromosome_stability4.26267270
3MP0008057_abnormal_DNA_replication4.25470642
4MP0003111_abnormal_nucleus_morphology3.83907078
5MP0008058_abnormal_DNA_repair3.63043571
6MP0003077_abnormal_cell_cycle3.49924683
7MP0004957_abnormal_blastocyst_morpholog3.43356816
8MP0008007_abnormal_cellular_replicative2.84245719
9MP0002396_abnormal_hematopoietic_system2.44288472
10MP0002254_reproductive_system_inflammat2.20207175
11MP0003718_maternal_effect2.19273875
12MP0008932_abnormal_embryonic_tissue2.15617849
13MP0003786_premature_aging2.12413529
14MP0006292_abnormal_olfactory_placode2.09034603
15MP0003763_abnormal_thymus_physiology1.92588892
16MP0005671_abnormal_response_to1.90065487
17MP0009333_abnormal_splenocyte_physiolog1.84596861
18MP0001835_abnormal_antigen_presentation1.84396230
19MP0008877_abnormal_DNA_methylation1.78736874
20MP0006035_abnormal_mitochondrial_morpho1.77495085
21MP0000350_abnormal_cell_proliferation1.72385092
22MP0000490_abnormal_crypts_of1.71530439
23MP0003806_abnormal_nucleotide_metabolis1.68171630
24MP0009785_altered_susceptibility_to1.66793658
25MP0001730_embryonic_growth_arrest1.63169639
26MP0002132_abnormal_respiratory_system1.59948555
27MP0002398_abnormal_bone_marrow1.58963470
28MP0008789_abnormal_olfactory_epithelium1.52937595
29MP0003186_abnormal_redox_activity1.49449266
30MP0001800_abnormal_humoral_immune1.48808659
31MP0003941_abnormal_skin_development1.45648296
32MP0000689_abnormal_spleen_morphology1.44149877
33MP0004808_abnormal_hematopoietic_stem1.41426203
34MP0010307_abnormal_tumor_latency1.38734392
35MP0002722_abnormal_immune_system1.37652455
36MP0002210_abnormal_sex_determination1.35421503
37MP0002019_abnormal_tumor_incidence1.33979423
38MP0000313_abnormal_cell_death1.32961324
39MP0005397_hematopoietic_system_phenotyp1.32808929
40MP0001545_abnormal_hematopoietic_system1.32808929
41MP0000685_abnormal_immune_system1.32072348
42MP0002723_abnormal_immune_serum1.31125487
43MP0002452_abnormal_antigen_presenting1.29827926
44MP0000716_abnormal_immune_system1.28188563
45MP0002420_abnormal_adaptive_immunity1.27610968
46MP0002429_abnormal_blood_cell1.26654805
47MP0001819_abnormal_immune_cell1.26040480
48MP0003123_paternal_imprinting1.24994557
49MP0000703_abnormal_thymus_morphology1.23943639
50MP0005025_abnormal_response_to1.21746816
51MP0002148_abnormal_hypersensitivity_rea1.19315864
52MP0005000_abnormal_immune_tolerance1.18620800
53MP0001929_abnormal_gametogenesis1.18549356
54MP0001853_heart_inflammation1.18255256
55MP0005380_embryogenesis_phenotype1.17338522
56MP0001672_abnormal_embryogenesis/_devel1.17338522
57MP0003656_abnormal_erythrocyte_physiolo1.16882900
58MP0005501_abnormal_skin_physiology1.14880546
59MP0002006_tumorigenesis1.12537199
60MP0002405_respiratory_system_inflammati1.12339506
61MP0003221_abnormal_cardiomyocyte_apopto1.12048494
62MP0003724_increased_susceptibility_to1.11508108
63MP0001764_abnormal_homeostasis1.11458660
64MP0001145_abnormal_male_reproductive1.11100343
65MP0001697_abnormal_embryo_size1.09390050
66MP0000516_abnormal_urinary_system1.08352807
67MP0005367_renal/urinary_system_phenotyp1.08352807
68MP0005410_abnormal_fertilization1.08271745
69MP0005075_abnormal_melanosome_morpholog1.05617331
70MP0003950_abnormal_plasma_membrane1.05247840
71MP0002080_prenatal_lethality1.03582546
72MP0003984_embryonic_growth_retardation1.03364811
73MP0002009_preneoplasia1.02846088
74MP0004147_increased_porphyrin_level1.02320698
75MP0002160_abnormal_reproductive_system1.02151460
76MP0005499_abnormal_olfactory_system1.00485146
77MP0005394_taste/olfaction_phenotype1.00485146
78MP0002166_altered_tumor_susceptibility1.00368176
79MP0000653_abnormal_sex_gland0.99567920
80MP0002088_abnormal_embryonic_growth/wei0.99295998
81MP0009764_decreased_sensitivity_to0.98844811
82MP0002419_abnormal_innate_immunity0.98642448
83MP0003436_decreased_susceptibility_to0.97194677
84MP0001790_abnormal_immune_system0.96799790
85MP0005387_immune_system_phenotype0.96799790
86MP0001119_abnormal_female_reproductive0.96719904
87MP0005389_reproductive_system_phenotype0.96536759
88MP0010352_gastrointestinal_tract_polyps0.95991065
89MP0000858_altered_metastatic_potential0.94043136
90MP0002277_abnormal_respiratory_mucosa0.94003979
91MP0010155_abnormal_intestine_physiology0.93475098
92MP0008260_abnormal_autophagy0.93429686
93MP0009697_abnormal_copulation0.93084889
94MP0000015_abnormal_ear_pigmentation0.92889857
95MP0002796_impaired_skin_barrier0.85861528
96MP0005464_abnormal_platelet_physiology0.85011288
97MP0002085_abnormal_embryonic_tissue0.83384926
98MP0002086_abnormal_extraembryonic_tissu0.82999643
99MP0001845_abnormal_inflammatory_respons0.80497981
100MP0000465_gastrointestinal_hemorrhage0.78874576
101MP0008873_increased_physiological_sensi0.78524888
102MP0001727_abnormal_embryo_implantation0.78311043
103MP0001293_anophthalmia0.77042123
104MP0005451_abnormal_body_composition0.76739631
105MP0001919_abnormal_reproductive_system0.76138794
106MP0001873_stomach_inflammation0.75322109
107MP0003448_altered_tumor_morphology0.74952847
108MP0002090_abnormal_vision0.74849448
109MP0005360_urolithiasis0.74416098
110MP0004264_abnormal_extraembryonic_tissu0.73757138
111MP0008995_early_reproductive_senescence0.71957076
112MP0004233_abnormal_muscle_weight0.71573993
113MP0002084_abnormal_developmental_patter0.71107514
114MP0006082_CNS_inflammation0.69902531
115MP0005058_abnormal_lysosome_morphology0.69402623
116MP0002653_abnormal_ependyma_morphology0.69243983
117MP0009765_abnormal_xenobiotic_induced0.68112592
118MP0006036_abnormal_mitochondrial_physio0.67201780
119MP0005408_hypopigmentation0.66274818
120MP0003315_abnormal_perineum_morphology0.66102303
121MP0003567_abnormal_fetal_cardiomyocyte0.66034023
122MP0000358_abnormal_cell_content/0.65012688
123MP0008469_abnormal_protein_level0.64383823
124MP0009672_abnormal_birth_weight0.63848671
125MP0009840_abnormal_foam_cell0.63347687
126MP0005384_cellular_phenotype0.63277879
127MP0005395_other_phenotype0.63203807
128MP0005621_abnormal_cell_physiology0.63106434
129MP0004197_abnormal_fetal_growth/weight/0.62861360

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.25874813
2Chromsome breakage (HP:0040012)3.92206622
3Chromosomal breakage induced by crosslinking agents (HP:0003221)3.91858079
4Breast hypoplasia (HP:0003187)3.90058366
5Abnormal protein glycosylation (HP:0012346)3.68118782
6Abnormal glycosylation (HP:0012345)3.68118782
7Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.68118782
8Abnormal protein N-linked glycosylation (HP:0012347)3.68118782
9Abnormal number of erythroid precursors (HP:0012131)3.40798075
10Multiple enchondromatosis (HP:0005701)3.37785746
11Carpal bone hypoplasia (HP:0001498)3.34217656
12Abnormality of cells of the erythroid lineage (HP:0012130)3.32182516
13Increased hepatocellular lipid droplets (HP:0006565)3.31267278
14Lipid accumulation in hepatocytes (HP:0006561)3.30131133
15Abnormality of the preputium (HP:0100587)3.25647724
16Reticulocytopenia (HP:0001896)3.17788383
17Meckel diverticulum (HP:0002245)3.16006706
18Acute necrotizing encephalopathy (HP:0006965)3.15328959
19Abnormality of chromosome stability (HP:0003220)3.14758317
20Abnormal mitochondria in muscle tissue (HP:0008316)3.14242226
21Aplastic anemia (HP:0001915)3.14110071
22Degeneration of anterior horn cells (HP:0002398)3.11828760
23Abnormality of the anterior horn cell (HP:0006802)3.11828760
24Decreased activity of mitochondrial respiratory chain (HP:0008972)3.07651594
25Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.07651594
26Patellar aplasia (HP:0006443)3.06051536
27Increased CSF lactate (HP:0002490)3.05318783
28Oral leukoplakia (HP:0002745)3.02691168
29Abnormality of the ileum (HP:0001549)2.95925913
30Acute encephalopathy (HP:0006846)2.95903728
31Impulsivity (HP:0100710)2.91195842
32Aplasia/Hypoplasia of the patella (HP:0006498)2.89609899
33Mitochondrial inheritance (HP:0001427)2.88758449
34Aplasia/Hypoplasia of the uvula (HP:0010293)2.86393186
35Increased serum pyruvate (HP:0003542)2.84206057
36Abnormality of glycolysis (HP:0004366)2.83648868
37Hepatocellular necrosis (HP:0001404)2.82247632
38Renal Fanconi syndrome (HP:0001994)2.78235363
39Myelodysplasia (HP:0002863)2.75830802
40Abnormal spermatogenesis (HP:0008669)2.74129346
41Rough bone trabeculation (HP:0100670)2.73104787
42Bone marrow hypocellularity (HP:0005528)2.64909019
43Cholecystitis (HP:0001082)2.64409616
44Abnormal gallbladder physiology (HP:0012438)2.64409616
45Cerebral hypomyelination (HP:0006808)2.56523383
46Stenosis of the external auditory canal (HP:0000402)2.54336509
47Small intestinal stenosis (HP:0012848)2.54041497
48Duodenal stenosis (HP:0100867)2.54041497
49Abnormality of methionine metabolism (HP:0010901)2.52426272
50IgM deficiency (HP:0002850)2.49055268
51Type 2 muscle fiber atrophy (HP:0003554)2.47665665
52Macrocytic anemia (HP:0001972)2.46815278
53Increased intramyocellular lipid droplets (HP:0012240)2.43725373
54Hepatic necrosis (HP:0002605)2.43519170
55IgG deficiency (HP:0004315)2.42781817
56Lactic acidosis (HP:0003128)2.40924010
57Abnormality of the heme biosynthetic pathway (HP:0010472)2.40485814
58Testicular atrophy (HP:0000029)2.40168991
59Absent thumb (HP:0009777)2.37091529
60Respiratory difficulties (HP:0002880)2.35369604
61Reduced antithrombin III activity (HP:0001976)2.33573454
62Exertional dyspnea (HP:0002875)2.32829927
63Clubbing of toes (HP:0100760)2.32414774
64Cerebral edema (HP:0002181)2.31652747
65Exercise intolerance (HP:0003546)2.30236187
66Progressive macrocephaly (HP:0004481)2.29437450
67Muscle fiber atrophy (HP:0100295)2.28820702
68Type I transferrin isoform profile (HP:0003642)2.28621380
69Postnatal microcephaly (HP:0005484)2.28612898
70Pallor (HP:0000980)2.25014357
71Hypoplastic pelvis (HP:0008839)2.22742191
72Pancytopenia (HP:0001876)2.20777936
73Increased muscle lipid content (HP:0009058)2.20521298
74Absent radius (HP:0003974)2.19699761
75Premature graying of hair (HP:0002216)2.19340893
76Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.18361692
77Lymphoma (HP:0002665)2.17622606
78Abnormal lung lobation (HP:0002101)2.13693336
79Agnosia (HP:0010524)2.12941856
80Sloping forehead (HP:0000340)2.11440423
81Abnormality of serum amino acid levels (HP:0003112)2.10367486
82Triphalangeal thumb (HP:0001199)2.10055083
83Prominent metopic ridge (HP:0005487)2.09166849
84Thrombocytosis (HP:0001894)2.08913449
85Abnormal trabecular bone morphology (HP:0100671)2.08804707
86Progressive external ophthalmoplegia (HP:0000590)2.07395232
87Methylmalonic acidemia (HP:0002912)2.07207052
88Poikiloderma (HP:0001029)2.07001642
89Abnormality of the duodenum (HP:0002246)2.03225244
90Colon cancer (HP:0003003)2.03118858
91Ectopic kidney (HP:0000086)2.02955556
92Supernumerary spleens (HP:0009799)2.02534007
93Acute hepatic failure (HP:0006554)2.02439350
94Selective tooth agenesis (HP:0001592)2.02229330
95Cleft eyelid (HP:0000625)2.02211779
96Cellular immunodeficiency (HP:0005374)2.01399807
97Aplasia involving forearm bones (HP:0009822)2.00986049
98Absent forearm bone (HP:0003953)2.00986049
99Secondary amenorrhea (HP:0000869)1.99692720
100Abnormality of T cell physiology (HP:0011840)1.98583331
101Microretrognathia (HP:0000308)1.98167770
102Methylmalonic aciduria (HP:0012120)1.97980997
1033-Methylglutaconic aciduria (HP:0003535)1.97637083
104Horseshoe kidney (HP:0000085)1.97475532
105Nonimmune hydrops fetalis (HP:0001790)1.97272732
10611 pairs of ribs (HP:0000878)1.95661663
107Abnormality of the pons (HP:0007361)1.95565568
108Azoospermia (HP:0000027)1.95548598
109Pustule (HP:0200039)1.94525083
110Abnormality of T cells (HP:0002843)1.94069078
111Shoulder girdle muscle weakness (HP:0003547)1.93675297
112Pancreatic cysts (HP:0001737)1.93095999
113Sensory axonal neuropathy (HP:0003390)1.92980076
114Progressive muscle weakness (HP:0003323)1.92488610
115Microvesicular hepatic steatosis (HP:0001414)1.92333623
116Optic nerve coloboma (HP:0000588)1.92289149
117Symptomatic seizures (HP:0011145)1.91200088
118Abnormality of alanine metabolism (HP:0010916)1.91181416
119Hyperalaninemia (HP:0003348)1.91181416
120Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.91181416
121Ragged-red muscle fibers (HP:0003200)1.91133057
122Pancreatic fibrosis (HP:0100732)1.91111087
123Aplasia/Hypoplasia involving the musculature (HP:0001460)1.91027524
124Tracheoesophageal fistula (HP:0002575)1.90662879
125Sparse eyelashes (HP:0000653)1.90547153
126Petechiae (HP:0000967)1.90458832
127Granulocytopenia (HP:0001913)1.88306317
128Nausea (HP:0002018)1.88096421
129Hypoplasia of the capital femoral epiphysis (HP:0003090)1.87925763
130Abnormality of the prostate (HP:0008775)1.86952586
131Neoplasm of the pancreas (HP:0002894)1.86141973
132CNS hypomyelination (HP:0003429)1.86135769
133Abnormality of aspartate family amino acid metabolism (HP:0010899)1.85860704
134Abnormality of pyrimidine metabolism (HP:0004353)1.85001597
135Duplicated collecting system (HP:0000081)1.84234715
136Premature ovarian failure (HP:0008209)1.84057633
137Entropion (HP:0000621)1.83495235
138Hypoplasia of the pons (HP:0012110)1.82907955
139Capillary hemangiomas (HP:0005306)1.82501759
140Irregular epiphyses (HP:0010582)1.81059330
141Increased IgM level (HP:0003496)1.80302705
142Abnormality of DNA repair (HP:0003254)1.80088409
143Aplasia/Hypoplasia of the sacrum (HP:0008517)1.78843972
144Encephalitis (HP:0002383)1.77818578
145Pulmonary fibrosis (HP:0002206)1.76119937
146Hyperglycinemia (HP:0002154)1.75999599
147Recurrent abscess formation (HP:0002722)1.74752408
148Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.74693146
149Abnormality of the renal collecting system (HP:0004742)1.74685240
150Eosinophilia (HP:0001880)1.72493105
151Combined immunodeficiency (HP:0005387)1.72201239
152Short thumb (HP:0009778)1.71246147
153Squamous cell carcinoma (HP:0002860)1.70295870
154Abnormality of T cell number (HP:0011839)1.70243418
155Increased serum lactate (HP:0002151)1.68774762
156Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.68774057

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.65453406
2EIF2AK14.19690774
3WEE13.98271882
4VRK23.58372001
5SRPK12.73942840
6EIF2AK32.62297260
7CDC72.60621691
8PLK42.53505419
9STK162.41927702
10TSSK62.36046549
11ACVR1B2.30488100
12BRSK22.29706296
13VRK12.13377143
14NEK21.90802598
15TRIM281.86638563
16NME21.83682636
17TLK11.81924964
18PLK11.77580283
19TXK1.75721352
20IRAK31.68496752
21MKNK11.67972999
22ZAK1.67833681
23TTK1.64192265
24EIF2AK21.62713268
25PLK31.62566757
26MAP4K11.52540490
27DYRK31.52459216
28MKNK21.49006428
29IRAK41.46326355
30PDK21.45156490
31PIM21.43217276
32BCKDK1.38376261
33CDK71.36045793
34AURKB1.35432898
35BRSK11.35402737
36ATR1.34457494
37TESK21.31945190
38CHEK21.27798596
39CCNB11.27398958
40STK41.22315273
41STK101.17752104
42PIM11.17732545
43PBK1.10007839
44TAF11.07887816
45RPS6KB21.07668969
46ERBB41.05594197
47AURKA1.03556431
48PASK0.95241823
49TEC0.93641734
50MST40.93456511
51MAP3K140.93225985
52CHEK10.92102907
53PAK40.91813475
54NEK10.91248419
55EPHA20.90665468
56IKBKB0.90117279
57FLT30.88486756
58RPS6KA40.85081521
59JAK30.83464181
60BTK0.80769354
61TYK20.80620889
62CLK10.79682284
63CDK40.77004671
64ATM0.72860578
65IRAK20.72806201
66NLK0.71471212
67KDR0.71186522
68KIT0.71019207
69AKT30.69840779
70DYRK20.69743852
71STK38L0.67660293
72MAP3K80.67340522
73CSNK2A10.66351872
74ZAP700.66309416
75SIK30.64730146
76IKBKE0.64340931
77CHUK0.62126776
78RPS6KA50.61854556
79TAOK20.61775137
80TESK10.61654328
81CDK80.60626624
82SCYL20.59252810
83MAP3K50.58028335
84NEK60.57807086
85CSNK2A20.57593822
86BLK0.56987270
87CDK20.56504924
88MELK0.55111773
89SMG10.54722936
90ALK0.54634799
91STK30.54595534
92MAP3K30.52893502
93LYN0.50558862
94MAPKAPK30.50404643
95NME10.48508630
96YES10.47683917
97STK240.46824928
98CDK120.46724764
99ARAF0.46443381
100IRAK10.46325089
101GRK70.44286995
102PRKCI0.43991342
103TGFBR10.43899985
104CDK10.43446062
105BMPR20.40750056
106PAK10.39806556
107EEF2K0.39603572
108ADRBK20.39505125
109ABL20.39395300
110BRAF0.39042172
111MARK30.38578187
112MAP2K30.36356245
113LCK0.36226330
114TBK10.36147403
115NUAK10.33352538
116ERBB30.33191544
117MAP3K100.33143638
118SYK0.31155296
119CSF1R0.30736355
120MAPKAPK50.30493791
121CDK60.29239999
122BRD40.28519824
123MAP3K120.27804433
124ITK0.27684677
125CSNK1G30.26420592
126MAP3K110.25368145
127DAPK10.25189168
128CDK190.24082001
129MATK0.24081796

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.01814434
2RNA polymerase_Homo sapiens_hsa030203.74360121
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.52207771
4Mismatch repair_Homo sapiens_hsa034303.30261199
5Proteasome_Homo sapiens_hsa030503.00782479
6Ribosome_Homo sapiens_hsa030102.89373808
7Spliceosome_Homo sapiens_hsa030402.80506733
8Homologous recombination_Homo sapiens_hsa034402.77655321
9RNA transport_Homo sapiens_hsa030132.59550184
10Pyrimidine metabolism_Homo sapiens_hsa002402.52463834
11Base excision repair_Homo sapiens_hsa034102.45949390
12Nucleotide excision repair_Homo sapiens_hsa034202.41731290
13Cell cycle_Homo sapiens_hsa041102.36300568
14One carbon pool by folate_Homo sapiens_hsa006702.32136878
15Fanconi anemia pathway_Homo sapiens_hsa034602.28795733
16Basal transcription factors_Homo sapiens_hsa030222.22587324
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.07044570
18Vitamin B6 metabolism_Homo sapiens_hsa007502.05163795
19Non-homologous end-joining_Homo sapiens_hsa034502.02597816
20RNA degradation_Homo sapiens_hsa030181.85100498
21Oxidative phosphorylation_Homo sapiens_hsa001901.72528871
22Parkinsons disease_Homo sapiens_hsa050121.69800592
23Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.64169730
24Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.59542822
25p53 signaling pathway_Homo sapiens_hsa041151.59111180
26Purine metabolism_Homo sapiens_hsa002301.47128666
272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.36235197
28Folate biosynthesis_Homo sapiens_hsa007901.35177088
29Drug metabolism - other enzymes_Homo sapiens_hsa009831.29453737
30Herpes simplex infection_Homo sapiens_hsa051681.25585663
31Protein export_Homo sapiens_hsa030601.24155055
32Primary immunodeficiency_Homo sapiens_hsa053401.23963798
33Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.23106089
34Epstein-Barr virus infection_Homo sapiens_hsa051691.22618953
35* mRNA surveillance pathway_Homo sapiens_hsa030151.20175539
36Antigen processing and presentation_Homo sapiens_hsa046121.15804165
37Graft-versus-host disease_Homo sapiens_hsa053321.14000627
38Caffeine metabolism_Homo sapiens_hsa002321.10955652
39Fatty acid elongation_Homo sapiens_hsa000621.06479981
40Pyruvate metabolism_Homo sapiens_hsa006201.06169959
41NF-kappa B signaling pathway_Homo sapiens_hsa040641.04707586
42Pentose phosphate pathway_Homo sapiens_hsa000301.04335199
43Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.03550324
44Allograft rejection_Homo sapiens_hsa053301.02816499
45Intestinal immune network for IgA production_Homo sapiens_hsa046721.01255663
46Measles_Homo sapiens_hsa051620.97705426
47Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.94290583
48Systemic lupus erythematosus_Homo sapiens_hsa053220.87257798
49Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.85587193
50Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.83969651
51Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.83905758
52Propanoate metabolism_Homo sapiens_hsa006400.78107242
53Regulation of autophagy_Homo sapiens_hsa041400.77256933
54Legionellosis_Homo sapiens_hsa051340.75341747
55Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.74430335
56Steroid biosynthesis_Homo sapiens_hsa001000.74122462
57Cysteine and methionine metabolism_Homo sapiens_hsa002700.73474254
58Alzheimers disease_Homo sapiens_hsa050100.73356686
59Autoimmune thyroid disease_Homo sapiens_hsa053200.72203454
60Selenocompound metabolism_Homo sapiens_hsa004500.71455659
61Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.71172204
62NOD-like receptor signaling pathway_Homo sapiens_hsa046210.70853157
63Cyanoamino acid metabolism_Homo sapiens_hsa004600.69586193
64N-Glycan biosynthesis_Homo sapiens_hsa005100.68867645
65Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.67726236
66Hematopoietic cell lineage_Homo sapiens_hsa046400.67068072
67RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.66401230
68Viral carcinogenesis_Homo sapiens_hsa052030.66096629
69Sulfur relay system_Homo sapiens_hsa041220.65668451
70Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.62111890
71Glutathione metabolism_Homo sapiens_hsa004800.61610522
72Sulfur metabolism_Homo sapiens_hsa009200.60355086
73Galactose metabolism_Homo sapiens_hsa000520.59421577
74Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.58218827
75Influenza A_Homo sapiens_hsa051640.54101092
76Asthma_Homo sapiens_hsa053100.52902480
77Biosynthesis of amino acids_Homo sapiens_hsa012300.52518464
78Arachidonic acid metabolism_Homo sapiens_hsa005900.48657405
79SNARE interactions in vesicular transport_Homo sapiens_hsa041300.48354512
80Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.48085006
81Transcriptional misregulation in cancer_Homo sapiens_hsa052020.45626436
82HTLV-I infection_Homo sapiens_hsa051660.44717560
83Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.43033075
84Leishmaniasis_Homo sapiens_hsa051400.42674151
85Vitamin digestion and absorption_Homo sapiens_hsa049770.41236676
86Apoptosis_Homo sapiens_hsa042100.41232810
87Huntingtons disease_Homo sapiens_hsa050160.40512785
88Jak-STAT signaling pathway_Homo sapiens_hsa046300.40453606
89Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.40248861
90Oocyte meiosis_Homo sapiens_hsa041140.39111926
91Peroxisome_Homo sapiens_hsa041460.37687557
92Hepatitis B_Homo sapiens_hsa051610.37427152
93Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37384242
94Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.36305740
95Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.36192936
96Metabolic pathways_Homo sapiens_hsa011000.35623338
97Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.34797441
98Thyroid cancer_Homo sapiens_hsa052160.34308123
99Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.33103100
100Viral myocarditis_Homo sapiens_hsa054160.32414303
101Small cell lung cancer_Homo sapiens_hsa052220.31081305
102Linoleic acid metabolism_Homo sapiens_hsa005910.28370746
103Chemical carcinogenesis_Homo sapiens_hsa052040.27724463
104Retinol metabolism_Homo sapiens_hsa008300.27680951
105Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.25875693
106Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.25732204
107Malaria_Homo sapiens_hsa051440.24988425
108Type I diabetes mellitus_Homo sapiens_hsa049400.24810148
109Toll-like receptor signaling pathway_Homo sapiens_hsa046200.23347635
110Other glycan degradation_Homo sapiens_hsa005110.23011998
111Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.22336488
112Bladder cancer_Homo sapiens_hsa052190.21529955
113Staphylococcus aureus infection_Homo sapiens_hsa051500.19536088
114Fructose and mannose metabolism_Homo sapiens_hsa000510.18936446
115Shigellosis_Homo sapiens_hsa051310.18434756
116Rheumatoid arthritis_Homo sapiens_hsa053230.18251166
117T cell receptor signaling pathway_Homo sapiens_hsa046600.17133129
118Lysosome_Homo sapiens_hsa041420.15958263
119Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.15865895
120Steroid hormone biosynthesis_Homo sapiens_hsa001400.15774136
121Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.15304659
122Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.15146415
123Tuberculosis_Homo sapiens_hsa051520.14956095
124MicroRNAs in cancer_Homo sapiens_hsa052060.14169887
125Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.12699985
126Carbon metabolism_Homo sapiens_hsa012000.12682874

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