CLPB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the ATP-ases associated with diverse cellular activities (AAA+) superfamily. Members of this superfamily form ring-shaped homo-hexamers and have highly conserved ATPase domains that are involved in various processes including DNA replication, protein degradation and reactivation of misfolded proteins. All members of this family hydrolyze ATP through their AAA+ domains and use the energy generated through ATP hydrolysis to exert mechanical force on their substrates. In addition to an AAA+ domain, the protein encoded by this gene contains a C-terminal D2 domain, which is characteristic of the AAA+ subfamily of Caseinolytic peptidases to which this protein belongs. It cooperates with Hsp70 in the disaggregation of protein aggregates. Allelic variants of this gene are associated with 3-methylglutaconic aciduria, which causes cataracts and neutropenia. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1acrosome reaction (GO:0007340)9.78841606
2fusion of sperm to egg plasma membrane (GO:0007342)9.74628015
3sperm-egg recognition (GO:0035036)9.46295776
4binding of sperm to zona pellucida (GO:0007339)8.84190942
5acrosome assembly (GO:0001675)8.64099834
6cell-cell recognition (GO:0009988)8.40052312
7spermatid development (GO:0007286)7.96954466
8multicellular organism reproduction (GO:0032504)7.77440712
9plasma membrane fusion (GO:0045026)7.46745558
10epithelial cilium movement (GO:0003351)7.42137912
11motile cilium assembly (GO:0044458)7.41183298
12nuclear pore complex assembly (GO:0051292)7.03795559
13axonemal dynein complex assembly (GO:0070286)6.95285921
14reproduction (GO:0000003)6.88342213
15regulation of cilium movement (GO:0003352)6.86917580
16organic cation transport (GO:0015695)6.32149058
17synaptonemal complex organization (GO:0070193)6.01615669
18synaptonemal complex assembly (GO:0007130)6.01420629
19sperm capacitation (GO:0048240)5.90502030
20nuclear pore organization (GO:0006999)5.87178666
21piRNA metabolic process (GO:0034587)5.84636440
22cilium movement (GO:0003341)5.80158824
23negative regulation of inclusion body assembly (GO:0090084)5.70016393
24spermatogenesis (GO:0007283)5.60960453
25male meiosis (GO:0007140)5.60877790
26male gamete generation (GO:0048232)5.59543478
27cilium or flagellum-dependent cell motility (GO:0001539)5.38639333
28pore complex assembly (GO:0046931)5.33564280
29microtubule depolymerization (GO:0007019)5.33428020
30single fertilization (GO:0007338)5.32114655
31regulation of inclusion body assembly (GO:0090083)5.30114652
32epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.23487611
33chromosome condensation (GO:0030261)5.12394574
34rRNA methylation (GO:0031167)5.11844282
35gamete generation (GO:0007276)5.11379500
36DNA packaging (GO:0006323)4.89624314
37fertilization (GO:0009566)4.71883324
38DNA unwinding involved in DNA replication (GO:0006268)4.63609968
39chaperone-mediated protein complex assembly (GO:0051131)4.54106168
40rRNA modification (GO:0000154)4.53960889
41germ cell development (GO:0007281)4.51693779
42glycerol ether metabolic process (GO:0006662)4.50562549
43DNA conformation change (GO:0071103)4.48856705
44mitotic chromosome condensation (GO:0007076)4.43618770
45single strand break repair (GO:0000012)4.40885947
46cellular process involved in reproduction in multicellular organism (GO:0022412)4.35764851
47calcium ion-dependent exocytosis (GO:0017156)4.33609496
48protein-DNA complex disassembly (GO:0032986)4.27570779
49nucleosome disassembly (GO:0006337)4.27570779
50carnitine transport (GO:0015879)4.19624387
51amino-acid betaine transport (GO:0015838)4.19624387
52ribosome assembly (GO:0042255)4.16645742
53regulation of translational fidelity (GO:0006450)4.16253756
54regulation of microtubule-based movement (GO:0060632)4.11766164
55ether metabolic process (GO:0018904)4.10594623
56carnitine transmembrane transport (GO:1902603)4.05254964
57chromosome organization involved in meiosis (GO:0070192)4.01699946
58multicellular organismal reproductive process (GO:0048609)4.01502624
59phosphatidylethanolamine biosynthetic process (GO:0006646)3.95325938
60cell recognition (GO:0008037)3.94407566
61DNA methylation involved in gamete generation (GO:0043046)3.92950576
62male meiosis I (GO:0007141)3.85365590
63microtubule severing (GO:0051013)3.83191539
64seminiferous tubule development (GO:0072520)3.83044033
65sexual reproduction (GO:0019953)3.76497467
66mitotic nuclear envelope disassembly (GO:0007077)3.67467137
67nuclear envelope disassembly (GO:0051081)3.64491271
68membrane disassembly (GO:0030397)3.64491271
69meiotic nuclear division (GO:0007126)3.64397278
70glycolytic process (GO:0006096)3.63728009
71ventricular system development (GO:0021591)3.61145274
72DNA strand elongation involved in DNA replication (GO:0006271)3.51080524
73phosphatidylethanolamine metabolic process (GO:0046337)3.47769251
74mitotic G1 DNA damage checkpoint (GO:0031571)3.47614881
75DNA replication initiation (GO:0006270)3.46166515
76regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.45079815
77DNA strand elongation (GO:0022616)3.41508180
78regulation of centriole replication (GO:0046599)3.39308102
79left/right pattern formation (GO:0060972)3.35818742
80COPI coating of Golgi vesicle (GO:0048205)3.35234747
81Golgi transport vesicle coating (GO:0048200)3.35234747
82peptidyl-lysine dimethylation (GO:0018027)3.29869846
83mitotic sister chromatid segregation (GO:0000070)3.28549933
84cytoskeletal anchoring at plasma membrane (GO:0007016)3.27304175
85regulation of histone H3-K27 methylation (GO:0061085)3.26142428
86spermatid nucleus differentiation (GO:0007289)3.24231744
87quaternary ammonium group transport (GO:0015697)3.23213868
88tricarboxylic acid cycle (GO:0006099)3.16014930
89peptidyl-arginine omega-N-methylation (GO:0035247)3.14291643
90CDP-diacylglycerol biosynthetic process (GO:0016024)3.14208383
91mitochondrial fusion (GO:0008053)3.13935914
92meiosis I (GO:0007127)3.13701652
93multicellular organismal development (GO:0007275)3.13657785
94carnitine shuttle (GO:0006853)3.10324919
95spliceosomal tri-snRNP complex assembly (GO:0000244)3.08396507
96protein refolding (GO:0042026)3.06031639
97sister chromatid segregation (GO:0000819)3.05096258
98positive regulation of chromosome segregation (GO:0051984)3.04019561
99alditol metabolic process (GO:0019400)3.03871611
100mitotic G1/S transition checkpoint (GO:0044819)3.02063189
101protein polyglutamylation (GO:0018095)2.98196692
102mitochondrial fission (GO:0000266)2.97577486
103G1 DNA damage checkpoint (GO:0044783)2.97529292
104chromatin silencing (GO:0006342)2.94994755
105protein export from nucleus (GO:0006611)2.93612391
106RNA localization (GO:0006403)2.93362554
107fructose metabolic process (GO:0006000)2.93217593
108polyamine biosynthetic process (GO:0006596)2.92634967
109aspartate family amino acid catabolic process (GO:0009068)2.91460681
110peptidyl-proline hydroxylation (GO:0019511)2.91322429
111nuclear envelope organization (GO:0006998)2.91026139
112regulation of spindle checkpoint (GO:0090231)2.90575649
113mitotic metaphase plate congression (GO:0007080)2.89299820
114protein complex localization (GO:0031503)2.88083793
115formation of translation preinitiation complex (GO:0001731)2.88020622
116tRNA methylation (GO:0030488)2.87761534
117DNA duplex unwinding (GO:0032508)2.87646911
118sequestering of actin monomers (GO:0042989)2.85323448
119CDP-diacylglycerol metabolic process (GO:0046341)2.85031502
120membrane protein intracellular domain proteolysis (GO:0031293)2.83554658
121telomere maintenance via semi-conservative replication (GO:0032201)2.83223367
122pyruvate metabolic process (GO:0006090)2.82861730
123interferon-gamma secretion (GO:0072643)2.82340489
124fatty acid transmembrane transport (GO:1902001)2.81374309
125regulation of translational termination (GO:0006449)2.81133170
126intracellular estrogen receptor signaling pathway (GO:0030520)2.79341671
127carnitine metabolic process (GO:0009437)2.78585451
128coronary vasculature morphogenesis (GO:0060977)2.78045271
129ribosome biogenesis (GO:0042254)2.76560035
130fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.75765989
131retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.75583405
132polyol catabolic process (GO:0046174)2.73010858
133regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.72956331
134positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.72079592
135protein retention in ER lumen (GO:0006621)2.71606244
136positive regulation of macrophage activation (GO:0043032)2.70354431
137nucleus organization (GO:0006997)2.69866104
138nucleobase-containing small molecule interconversion (GO:0015949)2.69056466
139negative regulation of histone methylation (GO:0031061)2.69039128
140genitalia morphogenesis (GO:0035112)2.68820618
141DNA geometric change (GO:0032392)2.68625408
142regulation of translational elongation (GO:0006448)2.68397081
143proline biosynthetic process (GO:0006561)2.66535380
144homeostasis of number of cells within a tissue (GO:0048873)2.66339532
145maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.66290463
146membrane protein ectodomain proteolysis (GO:0006509)2.65170989
147regulation of mammary gland epithelial cell proliferation (GO:0033599)2.64077096
148histone H3-K9 demethylation (GO:0033169)2.62218075
149regulation of chromosome segregation (GO:0051983)2.62132027
150protein localization to chromosome, centromeric region (GO:0071459)2.61720194
151amino-acid betaine metabolic process (GO:0006577)2.60229614
152meiotic cell cycle process (GO:1903046)2.54830301
153microtubule polymerization or depolymerization (GO:0031109)2.53857412
154meiotic cell cycle (GO:0051321)2.51397059
155glycerol metabolic process (GO:0006071)2.46966559
156protein K11-linked deubiquitination (GO:0035871)2.46565471
157positive regulation of glycolytic process (GO:0045821)2.45799989
158monoubiquitinated protein deubiquitination (GO:0035520)2.45619458
159peptidyl-glutamic acid modification (GO:0018200)2.43835198
160gene silencing (GO:0016458)2.43445183
161hexose biosynthetic process (GO:0019319)2.42785624
162nucleoside diphosphate phosphorylation (GO:0006165)2.38311214
163lysine metabolic process (GO:0006553)2.38126298
164sperm motility (GO:0030317)11.2071916
165cell wall macromolecule catabolic process (GO:0016998)10.5232270
166cell wall macromolecule metabolic process (GO:0044036)10.5232270

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.61163970
2E2F7_22180533_ChIP-Seq_HELA_Human6.92549253
3EZH2_22144423_ChIP-Seq_EOC_Human4.10291662
4PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.79179636
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.62640062
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.99618178
7* MYC_18555785_ChIP-Seq_MESCs_Mouse2.51282009
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.50060298
9HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.46401996
10* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.42625292
11MYC_22102868_ChIP-Seq_BL_Human2.22572104
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.21962408
13GATA1_26923725_Chip-Seq_HPCs_Mouse2.17475704
14LXR_22292898_ChIP-Seq_THP-1_Human2.16273017
15DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.08257080
16POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.06227092
17TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.04261820
18STAT6_21828071_ChIP-Seq_BEAS2B_Human2.00064372
19ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.98543800
20* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.91790932
21EGR1_19374776_ChIP-ChIP_THP-1_Human1.89039470
22E2F4_17652178_ChIP-ChIP_JURKAT_Human1.88631737
23AR_21909140_ChIP-Seq_LNCAP_Human1.87779929
24DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.87631130
25MYC_19030024_ChIP-ChIP_MESCs_Mouse1.85521840
26VDR_21846776_ChIP-Seq_THP-1_Human1.85235786
27ZNF274_21170338_ChIP-Seq_K562_Hela1.85042157
28* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.79041505
29SOX2_22085726_ChIP-Seq_NPCs_Mouse1.76150720
30MYC_19079543_ChIP-ChIP_MESCs_Mouse1.73644574
31FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.73214319
32ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.68304578
33TET1_21451524_ChIP-Seq_MESCs_Mouse1.65605759
34TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.64271350
35CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.62277060
36E2F1_21310950_ChIP-Seq_MCF-7_Human1.60969429
37NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.59853478
38GATA3_21867929_ChIP-Seq_CD8_Mouse1.59776600
39THAP11_20581084_ChIP-Seq_MESCs_Mouse1.59752252
40RXRA_24833708_ChIP-Seq_LIVER_Mouse1.59439083
41SRY_22984422_ChIP-ChIP_TESTIS_Rat1.59363666
42VDR_22108803_ChIP-Seq_LS180_Human1.58671716
43YY1_22570637_ChIP-Seq_MALME-3M_Human1.56894717
44NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.56082935
45KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.54633555
46* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.53567407
47FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.51567685
48PPARA_22158963_ChIP-Seq_LIVER_Mouse1.51215287
49ELK3_25401928_ChIP-Seq_HUVEC_Human1.51029069
50SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.49250447
51BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.49021341
52SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.48969982
53SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.48760837
54ELK4_26923725_Chip-Seq_MESODERM_Mouse1.48499303
55RACK7_27058665_Chip-Seq_MCF-7_Human1.48392497
56PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.48329926
57NELFA_20434984_ChIP-Seq_ESCs_Mouse1.47590472
58XRN2_22483619_ChIP-Seq_HELA_Human1.47111154
59FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.46770676
60* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.44060591
61ZFX_18555785_ChIP-Seq_MESCs_Mouse1.43955133
62EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.43616029
63STAT1_17558387_ChIP-Seq_HELA_Human1.43043663
64RAD21_21589869_ChIP-Seq_MESCs_Mouse1.42005423
65* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.39100884
66MYCN_18555785_ChIP-Seq_MESCs_Mouse1.37880709
67* SMC4_20622854_ChIP-Seq_HELA_Human1.37574221
68* RARA_24833708_ChIP-Seq_LIVER_Mouse1.36708885
69ZNF263_19887448_ChIP-Seq_K562_Human1.35303944
70* TCF7_22412390_ChIP-Seq_EML_Mouse1.35222895
71HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.34225108
72* P53_21459846_ChIP-Seq_SAOS-2_Human1.33672597
73LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.32712609
74ATF3_27146783_Chip-Seq_COLON_Human1.32198318
75* MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.31886902
76LXR_22158963_ChIP-Seq_LIVER_Mouse1.29170889
77TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28989847
78SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.28971282
79ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.28103082
80RXR_22158963_ChIP-Seq_LIVER_Mouse1.27472882
81KDM5A_27292631_Chip-Seq_BREAST_Human1.27005115
82KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.26836658
83ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.26492113
84JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.24982562
85NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.23278951
86PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.23125272
87CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22944849
88CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.22559474
89SPI1_26923725_Chip-Seq_HPCs_Mouse1.21965514
90* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.21331198
91SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21262044
92ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.20720593
93ELF1_20517297_ChIP-Seq_JURKAT_Human1.20169729
94RARG_19884340_ChIP-ChIP_MEFs_Mouse1.19915253
95KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.19743937
96GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.19483809
97GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18215457
98PKCTHETA_26484144_Chip-Seq_BREAST_Human1.17474318
99* BCOR_27268052_Chip-Seq_Bcells_Human1.17107259
100TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.17034596
101CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.16800659
102* PHF8_20622854_ChIP-Seq_HELA_Human1.16692406
103PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.16576771
104KAP1_22055183_ChIP-Seq_ESCs_Mouse1.16497020
105NCOR1_26117541_ChIP-Seq_K562_Human1.16174112
106MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.15993594
107TFEB_21752829_ChIP-Seq_HELA_Human1.15947010
108* SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.15417002
109CTCF_20526341_ChIP-Seq_ESCs_Human1.13802154
110UBF1/2_26484160_Chip-Seq_HMECs_Human1.13664969
111BCL6_27268052_Chip-Seq_Bcells_Human1.13460396
112* WDR5_24793694_ChIP-Seq_LNCAP_Human1.13317669
113ESR1_15608294_ChIP-ChIP_MCF-7_Human1.13151855
114STAT3_1855785_ChIP-Seq_MESCs_Mouse1.12500500
115PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.11478606
116DCP1A_22483619_ChIP-Seq_HELA_Human1.11326994
117KDM2B_26808549_Chip-Seq_DND41_Human1.11175018
118EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.11104085
119* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.09718405
120* ESET_19884257_ChIP-Seq_ESCs_Mouse1.09176519
121JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.08917530
122SA1_27219007_Chip-Seq_ERYTHROID_Human1.08788279
123RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.08152746
124RAC3_21632823_ChIP-Seq_H3396_Human1.08040721
125KDM2B_26808549_Chip-Seq_SUP-B15_Human1.07223087
126REST_21632747_ChIP-Seq_MESCs_Mouse1.07026131
127UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.06555443
128FLI1_27457419_Chip-Seq_LIVER_Mouse1.06454721
129BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.05411027
130* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.05327945
131RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.05187367
132CTCF_18555785_ChIP-Seq_MESCs_Mouse1.05173216
133KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.04913001
134CTCF_27219007_Chip-Seq_ERYTHROID_Human1.04600067
135MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.04144708
136TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.03801215
137KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.02928313
138THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.02610406
139FOXM1_23109430_ChIP-Seq_U2OS_Human1.02363996
140* ERG_20517297_ChIP-Seq_VCAP_Human1.01049038
141* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.01022927
142SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.00861330
143NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.00594750
144MYC_27129775_Chip-Seq_CORNEA_Mouse1.00360373
145RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.00256381
146SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.00135173
147* SOX11_22085726_ChIP-Seq_ESNs_Mouse0.99938849
148CHD1_26751641_Chip-Seq_LNCaP_Human0.99786137
149RUNX1_26923725_Chip-Seq_HPCs_Mouse0.98477019
150NANOG_21062744_ChIP-ChIP_HESCs_Human0.98391904
151TP53_22127205_ChIP-Seq_IMR90_Human0.98179541
152IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.98068566
153CBP_20019798_ChIP-Seq_JUKART_Human0.98068566
154* MYC_18358816_ChIP-ChIP_MESCs_Mouse0.97767396
155RUNX1_27514584_Chip-Seq_MCF-7_Human0.97528595
156MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.97098267
157GATA3_21867929_ChIP-Seq_TH1_Mouse0.96850980
158E2F1_20622854_ChIP-Seq_HELA_Human0.96170908
159LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.95474694
160* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.95471992
161CTCF_26484167_Chip-Seq_Bcells_Mouse0.95247707
162CSB_26484114_Chip-Seq_FIBROBLAST_Human0.95232263
163* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.94687181
164EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.94580790
165P68_20966046_ChIP-Seq_HELA_Human0.94327865
166GABP_19822575_ChIP-Seq_HepG2_Human0.94299354
167SOX2_21211035_ChIP-Seq_LN229_Human0.93802582
168CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.93325041
169EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.93052308
170TP63_17297297_ChIP-ChIP_HaCaT_Human0.92865520
171FLI1_21867929_ChIP-Seq_CD8_Mouse0.92119612
172RARB_24833708_ChIP-Seq_LIVER_Mouse0.92080187
173FOXP1_21924763_ChIP-Seq_HESCs_Human0.91961414
174CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.91667601
175* CTCF_27219007_Chip-Seq_Bcells_Human0.91564484
176RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.91328127
177SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.91162101

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive4.55877747
2MP0001929_abnormal_gametogenesis4.22749049
3MP0005670_abnormal_white_adipose3.90137603
4MP0003646_muscle_fatigue3.77132567
5MP0005451_abnormal_body_composition3.76828763
6MP0008877_abnormal_DNA_methylation3.20336027
7MP0002139_abnormal_hepatobiliary_system2.78206342
8MP0002210_abnormal_sex_determination2.68625502
9MP0004233_abnormal_muscle_weight2.64022584
10MP0002161_abnormal_fertility/fecundity2.58196328
11MP0002877_abnormal_melanocyte_morpholog2.57689233
12MP0003705_abnormal_hypodermis_morpholog2.45675593
13MP0003806_abnormal_nucleotide_metabolis2.32814373
14MP0001145_abnormal_male_reproductive2.30585168
15MP0010234_abnormal_vibrissa_follicle2.29679378
16MP0008057_abnormal_DNA_replication2.20431220
17MP0001348_abnormal_lacrimal_gland2.13028867
18MP0005360_urolithiasis2.12382805
19MP0005076_abnormal_cell_differentiation2.07382751
20MP0010352_gastrointestinal_tract_polyps2.00758609
21MP0005410_abnormal_fertilization12.0449248
22MP0002653_abnormal_ependyma_morphology1.97851759
23MP0000653_abnormal_sex_gland1.97628305
24MP0005365_abnormal_bile_salt1.97399789
25MP0002837_dystrophic_cardiac_calcinosis1.94718829
26MP0006036_abnormal_mitochondrial_physio1.85814496
27MP0005085_abnormal_gallbladder_physiolo1.84132815
28MP0000678_abnormal_parathyroid_gland1.83208608
29MP0010307_abnormal_tumor_latency1.80953800
30MP0000751_myopathy1.75615568
31MP0005666_abnormal_adipose_tissue1.72680713
32MP0002160_abnormal_reproductive_system1.67112776
33MP0002269_muscular_atrophy1.64030569
34MP0001661_extended_life_span1.62780827
35MP0008007_abnormal_cellular_replicative1.61963897
36MP0008932_abnormal_embryonic_tissue1.60883133
37MP0003566_abnormal_cell_adhesion1.57237107
38MP0004036_abnormal_muscle_relaxation1.54827896
39MP0000350_abnormal_cell_proliferation1.54314771
40MP0004130_abnormal_muscle_cell1.49675679
41MP0003718_maternal_effect1.48030462
42MP0003091_abnormal_cell_migration1.46561999
43MP0005058_abnormal_lysosome_morphology1.43481612
44MP0004084_abnormal_cardiac_muscle1.41739038
45MP0009840_abnormal_foam_cell1.39154374
46MP0008260_abnormal_autophagy1.36319775
47MP0004808_abnormal_hematopoietic_stem1.35738069
48MP0000749_muscle_degeneration1.32820106
49MP0005647_abnormal_sex_gland1.32536956
50MP0000003_abnormal_adipose_tissue1.31792092
51MP0006035_abnormal_mitochondrial_morpho1.29454768
52MP0000733_abnormal_muscle_development1.25259525
53MP0001849_ear_inflammation1.24976531
54MP0000313_abnormal_cell_death1.21795578
55MP0005332_abnormal_amino_acid1.18209997
56MP0010329_abnormal_lipoprotein_level1.16198321
57MP0003111_abnormal_nucleus_morphology1.12983960
58MP0005330_cardiomyopathy1.12110188
59MP0002086_abnormal_extraembryonic_tissu1.11554340
60MP0004145_abnormal_muscle_electrophysio1.11207482
61MP0001764_abnormal_homeostasis1.09130774
62MP0008058_abnormal_DNA_repair1.08839938
63MP0004087_abnormal_muscle_fiber1.08518644
64MP0010094_abnormal_chromosome_stability1.05942399
65MP0002009_preneoplasia1.03541363
66MP0004215_abnormal_myocardial_fiber1.01836126
67MP0002085_abnormal_embryonic_tissue0.98551775
68MP0008875_abnormal_xenobiotic_pharmacok0.97985605
69MP0005621_abnormal_cell_physiology0.97802246
70MP0003453_abnormal_keratinocyte_physiol0.96925981
71MP0003786_premature_aging0.96756060
72MP0003656_abnormal_erythrocyte_physiolo0.93555051
73MP0002822_catalepsy0.92505509
74MP0005319_abnormal_enzyme/_coenzyme0.92343864
75MP0005310_abnormal_salivary_gland0.91832680
76MP0004133_heterotaxia0.90748956
77MP0001727_abnormal_embryo_implantation0.87886572
78MP0001765_abnormal_ion_homeostasis0.87681906
79MP0002118_abnormal_lipid_homeostasis0.86750959
80MP0002106_abnormal_muscle_physiology0.86591458
81MP0009278_abnormal_bone_marrow0.86179319
82MP0002796_impaired_skin_barrier0.84982705
83MP0002396_abnormal_hematopoietic_system0.83995582
84MP0009053_abnormal_anal_canal0.83311040
85MP0002971_abnormal_brown_adipose0.83071529
86MP0002234_abnormal_pharynx_morphology0.83061954
87MP0002166_altered_tumor_susceptibility0.82777674
88MP0002084_abnormal_developmental_patter0.82393197
89MP0005375_adipose_tissue_phenotype0.82065586
90MP0005409_darkened_coat_color0.80889596
91MP0005266_abnormal_metabolism0.80750284
92MP0005384_cellular_phenotype0.79917180
93MP0000358_abnormal_cell_content/0.78631572
94MP0005389_reproductive_system_phenotype0.78370736
95MP0005501_abnormal_skin_physiology0.77668086
96MP0003011_delayed_dark_adaptation0.77637018
97MP0004957_abnormal_blastocyst_morpholog0.76384145
98MP0001730_embryonic_growth_arrest0.75047698
99MP0000759_abnormal_skeletal_muscle0.74279626
100MP0001915_intracranial_hemorrhage0.72634660
101MP0000750_abnormal_muscle_regeneration0.72536578
102MP0002249_abnormal_larynx_morphology0.72360282
103MP0003191_abnormal_cellular_cholesterol0.71770592
104MP0004019_abnormal_vitamin_homeostasis0.71770274
105MP0000534_abnormal_ureter_morphology0.71098784
106MP0003221_abnormal_cardiomyocyte_apopto0.70716898
107MP0002060_abnormal_skin_morphology0.70659086
108MP0005620_abnormal_muscle_contractility0.70343808
109MP0010630_abnormal_cardiac_muscle0.70104845
110MP0000747_muscle_weakness0.69708029
111MP0000681_abnormal_thyroid_gland0.69068625
112MP0005395_other_phenotype0.68415763
113MP0005636_abnormal_mineral_homeostasis0.65316135
114MP0005584_abnormal_enzyme/coenzyme_acti0.65073274
115MP0004043_abnormal_pH_regulation0.64931520
116MP0000490_abnormal_crypts_of0.64774995
117MP0003137_abnormal_impulse_conducting0.63645488
118MP0003186_abnormal_redox_activity0.63450779
119MP0002019_abnormal_tumor_incidence0.62085676
120MP0003172_abnormal_lysosome_physiology0.61532149
121MP0003252_abnormal_bile_duct0.60875761
122MP0004185_abnormal_adipocyte_glucose0.60749930
123MP0005369_muscle_phenotype0.60096608
124MP0009115_abnormal_fat_cell0.59871400
125MP0000609_abnormal_liver_physiology0.59385611
126MP0005380_embryogenesis_phenotype0.59267864
127MP0001672_abnormal_embryogenesis/_devel0.59267864
128MP0003283_abnormal_digestive_organ0.57869275
129MP0005535_abnormal_body_temperature0.57374409
130MP0000537_abnormal_urethra_morphology0.56847611
131MP0003699_abnormal_female_reproductive0.55848412
132MP0005083_abnormal_biliary_tract0.54413636
133MP0008995_early_reproductive_senescence0.54122789
134MP0005385_cardiovascular_system_phenoty0.53493391
135MP0001544_abnormal_cardiovascular_syste0.53493391
136MP0002970_abnormal_white_adipose0.53054284
137MP0005623_abnormal_meninges_morphology0.51788090
138MP0002078_abnormal_glucose_homeostasis0.51260275
139MP0003984_embryonic_growth_retardation0.51241230
140MP0003329_amyloid_beta_deposits0.50878590
141MP0002088_abnormal_embryonic_growth/wei0.49368333
142MP0005334_abnormal_fat_pad0.49338963
143MP0004085_abnormal_heartbeat0.48521040
144MP0003115_abnormal_respiratory_system0.47969521
145MP0008775_abnormal_heart_ventricle0.47734811
146MP0001697_abnormal_embryo_size0.47284221
147MP0009697_abnormal_copulation0.45875755
148MP0005377_hearing/vestibular/ear_phenot0.45362999
149MP0003878_abnormal_ear_physiology0.45362999
150MP0009672_abnormal_birth_weight0.45103979
151MP0002080_prenatal_lethality0.44556053
152MP0003077_abnormal_cell_cycle0.44453810
153MP0003693_abnormal_embryo_hatching0.44357709

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)9.68378416
2Abnormal respiratory epithelium morphology (HP:0012253)7.16873415
3Abnormal respiratory motile cilium morphology (HP:0005938)7.16873415
4Abnormal respiratory motile cilium physiology (HP:0012261)6.90413080
5Infertility (HP:0000789)5.94822741
6Chronic bronchitis (HP:0004469)5.88535123
7Rhinitis (HP:0012384)5.38865000
8Abnormal ciliary motility (HP:0012262)5.21849731
9Male infertility (HP:0003251)4.58441767
10Nasal polyposis (HP:0100582)4.55592170
11Resting tremor (HP:0002322)4.19341057
12Hyperacusis (HP:0010780)3.87179765
13Myoglobinuria (HP:0002913)3.82892051
14Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.73936926
15Abnormality of the nasal mucosa (HP:0000433)3.70821570
16Renovascular hypertension (HP:0100817)3.70790848
17Severe visual impairment (HP:0001141)3.67366128
18Exercise-induced myalgia (HP:0003738)3.50334498
19Rhabdomyolysis (HP:0003201)3.44910575
20Abnormal spermatogenesis (HP:0008669)3.41669216
21Abnormal gallbladder physiology (HP:0012438)3.08156318
22Cholecystitis (HP:0001082)3.08156318
23Termporal pattern (HP:0011008)3.07644923
24Insidious onset (HP:0003587)3.07644923
25Progressive sensorineural hearing impairment (HP:0000408)3.07285218
26Impulsivity (HP:0100710)2.99679371
27Bronchitis (HP:0012387)2.96093310
28Nephronophthisis (HP:0000090)2.92446951
29Short nail (HP:0001799)2.91818705
30Bronchiectasis (HP:0002110)2.88035375
31Progressive hearing impairment (HP:0001730)2.75410794
32Insomnia (HP:0100785)2.70009338
33Distal lower limb amyotrophy (HP:0008944)2.69039081
34Exercise-induced muscle cramps (HP:0003710)2.65179358
35Bundle branch block (HP:0011710)2.57824264
36Broad face (HP:0000283)2.54532767
37Aplasia/Hypoplasia of the sacrum (HP:0008517)2.50891757
38Unilateral renal agenesis (HP:0000122)2.50850943
39Osteolytic defects of the hand bones (HP:0009699)2.47218690
40Osteolytic defects of the phalanges of the hand (HP:0009771)2.47218690
41Chromosomal breakage induced by crosslinking agents (HP:0003221)2.46051702
42Hypergonadotropic hypogonadism (HP:0000815)2.44542520
43Centrally nucleated skeletal muscle fibers (HP:0003687)2.43354502
44Tubulointerstitial nephritis (HP:0001970)2.42079800
45Asymmetric septal hypertrophy (HP:0001670)2.39528997
46Patellar dislocation (HP:0002999)2.38214363
47Achilles tendon contracture (HP:0001771)2.33679358
48Spastic tetraparesis (HP:0001285)2.33609137
49Menstrual irregularities (HP:0000858)2.32488986
50Azoospermia (HP:0000027)2.28026709
51Difficulty climbing stairs (HP:0003551)2.27904456
52Distal lower limb muscle weakness (HP:0009053)2.25222064
53Aplasia/Hypoplasia of the earlobes (HP:0009906)2.23408997
54Ketosis (HP:0001946)2.23373757
55Abnormal large intestine physiology (HP:0012700)2.22949218
56Bell-shaped thorax (HP:0001591)2.22598105
57Overriding aorta (HP:0002623)2.21727411
58Bowel incontinence (HP:0002607)2.21365075
59Hyperglycinuria (HP:0003108)2.21102202
60Gonadotropin excess (HP:0000837)2.20156701
61Abnormality of the lower motor neuron (HP:0002366)2.19299191
62Ulnar bowing (HP:0003031)2.17576822
63Cholelithiasis (HP:0001081)2.15995184
64Hyporeflexia of lower limbs (HP:0002600)2.15436042
65Upper limb muscle weakness (HP:0003484)2.15211900
66Trismus (HP:0000211)2.15208890
67Distal upper limb amyotrophy (HP:0007149)2.13440486
68Upper limb amyotrophy (HP:0009129)2.13440486
69Hyperglycinemia (HP:0002154)2.12868516
70Chromsome breakage (HP:0040012)2.09364794
71Dyschromatopsia (HP:0007641)2.08993658
72Abnormality of the Achilles tendon (HP:0005109)2.08720451
73Abnormality of the renal medulla (HP:0100957)2.08057273
74Reticulocytosis (HP:0001923)2.07868671
75Elfin facies (HP:0004428)2.06234664
76Subcapsular cataract (HP:0000523)2.05845134
77Upper motor neuron abnormality (HP:0002127)2.05806916
78Tubulointerstitial abnormality (HP:0001969)2.04575832
79Hyperammonemia (HP:0001987)2.04448086
80Recurrent otitis media (HP:0000403)2.04208446
81Sudden death (HP:0001699)2.02368756
82Advanced eruption of teeth (HP:0006288)2.00784611
83Obsessive-compulsive behavior (HP:0000722)2.00516180
84Ankyloglossia (HP:0010296)2.00460859
85Dynein arm defect of respiratory motile cilia (HP:0012255)10.3186150
86Absent/shortened dynein arms (HP:0200106)10.3186150
87Deviation of the thumb (HP:0009603)1.99819184
88Abnormality of the distal phalanges of the toes (HP:0010182)1.96696806
89Abnormality of glycolysis (HP:0004366)1.96684634
90Multiple enchondromatosis (HP:0005701)1.96308500
91Truncus arteriosus (HP:0001660)1.96268421
92Abnormality of serine family amino acid metabolism (HP:0010894)1.95747633
93Abnormality of glycine metabolism (HP:0010895)1.95747633
94Abnormality of fatty-acid metabolism (HP:0004359)1.94982714
95Abnormality of the tricuspid valve (HP:0001702)1.92787169
96Hypoparathyroidism (HP:0000829)1.92386178
97Sandal gap (HP:0001852)1.92336414
98Increased nuchal translucency (HP:0010880)1.91655732
99Lower limb amyotrophy (HP:0007210)1.90136292
100Selective tooth agenesis (HP:0001592)1.88979271
101Microvesicular hepatic steatosis (HP:0001414)1.87191727
102Insulin resistance (HP:0000855)1.86459191
103Glossoptosis (HP:0000162)1.85303818
104Abnormality of the parathyroid morphology (HP:0011766)1.84229580
105Hand muscle atrophy (HP:0009130)1.84077766
106Colitis (HP:0002583)1.83715062
107Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.83470924
108Double outlet right ventricle (HP:0001719)1.82749862
109Congenital malformation of the right heart (HP:0011723)1.82749862
110Orthostatic hypotension (HP:0001278)1.82702876
111Hyperkalemia (HP:0002153)1.82275805
112Abnormality of the distal phalanx of the thumb (HP:0009617)1.82234600
113Abnormality of oral frenula (HP:0000190)1.81821547
114Proximal placement of thumb (HP:0009623)1.81171190
115EMG: neuropathic changes (HP:0003445)1.80134773
116Narrow face (HP:0000275)1.78681040
117Natal tooth (HP:0000695)1.78180073
118Flattened epiphyses (HP:0003071)1.77996312
119Difficulty running (HP:0009046)1.77419900
120Generalized muscle weakness (HP:0003324)1.77167741
121Sensory axonal neuropathy (HP:0003390)1.74551027
122Hypoplasia of the thymus (HP:0000778)1.74066378
123Dicarboxylic aciduria (HP:0003215)1.73502447
124Abnormality of dicarboxylic acid metabolism (HP:0010995)1.73502447
125Cone-rod dystrophy (HP:0000548)1.72941695
126Asymmetry of the thorax (HP:0001555)1.72931395
127Premature rupture of membranes (HP:0001788)1.72724045
128Abnormality of the gallbladder (HP:0005264)1.72492176
129Cerebellar dysplasia (HP:0007033)1.72068755
130Tubular atrophy (HP:0000092)1.72029161
131Renal duplication (HP:0000075)1.71878680
132Recurrent sinusitis (HP:0011108)1.70352775
133Abnormal gallbladder morphology (HP:0012437)1.69617063
134Dysmetric saccades (HP:0000641)1.68299826
135Ragged-red muscle fibers (HP:0003200)1.67806954
136Hyperthyroidism (HP:0000836)1.67780402
137Heart block (HP:0012722)1.66891363
138Insulin-resistant diabetes mellitus (HP:0000831)1.66250118
139Hypertriglyceridemia (HP:0002155)1.66172586
140Esophageal varix (HP:0002040)1.65953735
141Vertebral compression fractures (HP:0002953)1.65678702
142Septate vagina (HP:0001153)1.65464753
143Precocious puberty (HP:0000826)1.65167731
144Hypercholesterolemia (HP:0003124)1.65143243
145Abnormality of serum amino acid levels (HP:0003112)1.64414182
146Hemorrhage of the eye (HP:0011885)1.63603109
147Abnormality of the renal cortex (HP:0011035)1.63053107
148Hypoalphalipoproteinemia (HP:0003233)1.62865208
149Heterotopia (HP:0002282)1.62028682
150Progressive muscle weakness (HP:0003323)1.61553644
151Tubulointerstitial fibrosis (HP:0005576)1.60882191
152Cerebral edema (HP:0002181)1.60159259
153Polydipsia (HP:0001959)1.59342753
154Abnormal drinking behavior (HP:0030082)1.59342753
155Bile duct proliferation (HP:0001408)1.59271361
156Abnormal biliary tract physiology (HP:0012439)1.59271361
157Abnormality of renal excretion (HP:0011036)1.58719727
158Calf muscle hypertrophy (HP:0008981)1.57987753
159Decreased electroretinogram (ERG) amplitude (HP:0000654)1.57535011
160Choroideremia (HP:0001139)1.56633783
161Molar tooth sign on MRI (HP:0002419)1.56530939
162Abnormality of midbrain morphology (HP:0002418)1.56530939
163Progressive external ophthalmoplegia (HP:0000590)1.54878266
164Abnormal atrioventricular conduction (HP:0005150)1.52124151
165Easy fatigability (HP:0003388)1.50109807
166Lethargy (HP:0001254)1.49995119
167Global brain atrophy (HP:0002283)1.48855232
168Gout (HP:0001997)1.48821367
169Intrahepatic cholestasis (HP:0001406)1.48576588
170Acute encephalopathy (HP:0006846)1.47582228
171Ketoacidosis (HP:0001993)1.47184580
172Malnutrition (HP:0004395)1.46644191
173Transposition of the great arteries (HP:0001669)1.46309062
174Abnormal connection of the cardiac segments (HP:0011545)1.46309062
175Abnormal ventriculo-arterial connection (HP:0011563)1.46309062
176Increased connective tissue (HP:0009025)1.45675882
177Abnormal urine output (HP:0012590)1.44970335
178Muscle fibrillation (HP:0010546)1.43524468
179Muscle fiber splitting (HP:0003555)1.42399882
180Muscle hypertrophy of the lower extremities (HP:0008968)1.42381323
181Abnormality of aromatic amino acid family metabolism (HP:0004338)1.41518579
182Ependymoma (HP:0002888)1.41134987
183Hypolipoproteinemia (HP:0010981)1.40717118
184Lactic acidosis (HP:0003128)1.40384824

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK47.61359836
2PDK37.61359836
3TESK15.61293962
4PDK24.88321309
5PRKD34.55192558
6ICK4.46901495
7SMG12.76315196
8MST1R2.72540588
9NME22.60867897
10IRAK32.46396845
11SCYL22.27412215
12BCKDK2.05065713
13STK381.94790249
14PBK1.92887517
15CAMK1D1.88107740
16NEK21.71841545
17WNK41.64967255
18PINK11.64425112
19PTK2B1.54208566
20BRD41.53845403
21PNCK1.53331093
22ARAF1.49593176
23PRPF4B1.45842380
24LMTK21.43097851
25MAP3K81.42619300
26MAP3K91.39097304
27DDR21.38577839
28TTK1.38066145
29KSR21.38023179
30SRPK11.34191847
31STK38L1.25683342
32DYRK1B1.23105395
33STK391.18617616
34TLK11.06638228
35PDK11.04619606
36ZAK1.03809132
37MAP3K101.01008137
38EEF2K0.96307222
39DYRK30.94543021
40TTN0.93075205
41CDK80.92430533
42MET0.92209162
43NEK10.91991660
44BUB10.90814044
45MAPK110.90430644
46WEE10.89452063
47NEK60.89413117
48CDC70.89391831
49EIF2AK10.88935490
50RPS6KB20.86994865
51OBSCN0.83734881
52MAP3K130.80356781
53PIM20.78220449
54PDPK10.74364965
55CHEK20.72506027
56PHKG10.71570974
57PHKG20.71570974
58TYRO30.70681504
59MAP3K10.69322485
60CCNB10.68135761
61TRIB30.67676572
62MAP2K30.62674698
63MUSK0.62306718
64PLK10.61457803
65RAF10.59380873
66MTOR0.56708185
67AKT20.55098980
68PRKAA10.55074390
69MAP2K60.54723863
70AKT30.52949484
71ATR0.51951478
72PAK20.51603778
73RPS6KA50.49016300
74MAP2K20.48574833
75PDGFRA0.48518887
76PAK40.46591448
77CHEK10.46119633
78SIK10.45210205
79PRKCG0.44998574
80VRK10.43899807
81MAP3K40.43150528
82RPS6KA20.42991358
83IRAK10.42171393
84MAP3K20.41385090
85TESK20.41099672
86RPS6KB10.40689857
87MAP2K40.40166906
88MAP3K110.39568554
89EIF2AK30.38725036
90NEK90.37627516
91MOS0.37614661
92STK40.37404912
93PIK3CG0.36922789
94PASK0.36165109
95MELK0.35416341
96FGFR40.34954330
97TAOK20.34500372
98IRAK20.34464754
99CDK90.33500676
100RET0.32834195
101STK100.32122983
102LATS10.32077837
103PLK40.31748166
104ATM0.31657399
105RPS6KA10.30832629
106STK30.30635915
107ILK0.30568288
108CDK120.30377424
109WNK10.30178898
110MAPK140.29226729
111BRAF0.28712633
112AURKA0.28529171
113PAK10.27448678
114PKN20.26868020
115MAP3K50.26770415
116BRSK10.26537131
117CDK40.26237909
118BRSK20.25232098
119NTRK20.24792686
120MAPKAPK30.22506521
121TSSK60.22363906
122EPHA20.21449908
123PRKCZ0.20001875
124CDK20.19971495
125CSNK1E0.19887595
126MINK10.19500709
127PRKACG0.18829277
128MAPK150.18778735
129CAMK1G0.18607582
130CSNK2A10.18471188
131CSNK2A20.18009663
132PRKACB0.17151990
133RIPK10.16698187
134CDK10.16539419
135CDK60.16512122
136AURKB0.15822079
137GSK3B0.14294532
138RPS6KA30.13142707
139NME10.11573857
140MARK10.10971629
141CAMK2A0.10580022
142CDK70.10318135
143MYLK0.09751555
144CAMK2G0.08888767
145PRKDC0.08032439
146CSNK1D0.07246489
147PRKACA0.06720810
148LATS20.06624192
149MAPK80.06106929

Predicted pathways (KEGG)

RankGene SetZ-score
1Propanoate metabolism_Homo sapiens_hsa006403.62980948
2Fatty acid biosynthesis_Homo sapiens_hsa000613.35887964
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.24580682
4Pyruvate metabolism_Homo sapiens_hsa006203.22499168
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.96066923
6Fatty acid degradation_Homo sapiens_hsa000712.85633926
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.56092495
8Fatty acid metabolism_Homo sapiens_hsa012122.55247499
9Carbon metabolism_Homo sapiens_hsa012002.53694698
10Vitamin B6 metabolism_Homo sapiens_hsa007502.23371509
112-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.22828814
12Selenocompound metabolism_Homo sapiens_hsa004502.16169726
13Alcoholism_Homo sapiens_hsa050342.14109660
14Biosynthesis of amino acids_Homo sapiens_hsa012302.09063025
15Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.08970065
16PPAR signaling pathway_Homo sapiens_hsa033202.06253072
17Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.99395569
18Cell cycle_Homo sapiens_hsa041101.92017848
19Fructose and mannose metabolism_Homo sapiens_hsa000511.85553940
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.81242880
21Cysteine and methionine metabolism_Homo sapiens_hsa002701.80180844
22Glucagon signaling pathway_Homo sapiens_hsa049221.73478088
23Viral carcinogenesis_Homo sapiens_hsa052031.72987835
24Glycerolipid metabolism_Homo sapiens_hsa005611.70029419
25alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.53986475
26Fat digestion and absorption_Homo sapiens_hsa049751.50191847
27Cardiac muscle contraction_Homo sapiens_hsa042601.49426201
28Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.48544073
29Linoleic acid metabolism_Homo sapiens_hsa005911.42876401
30Chronic myeloid leukemia_Homo sapiens_hsa052201.42349631
31Thyroid cancer_Homo sapiens_hsa052161.41621447
32Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.40547245
33Non-small cell lung cancer_Homo sapiens_hsa052231.40463587
34Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.36984632
35Bladder cancer_Homo sapiens_hsa052191.36217034
36Pentose phosphate pathway_Homo sapiens_hsa000301.35385612
37Primary bile acid biosynthesis_Homo sapiens_hsa001201.32977179
38Nucleotide excision repair_Homo sapiens_hsa034201.31278267
39Spliceosome_Homo sapiens_hsa030401.24792490
40Arginine biosynthesis_Homo sapiens_hsa002201.23122966
41Acute myeloid leukemia_Homo sapiens_hsa052211.22879838
42Other glycan degradation_Homo sapiens_hsa005111.21598057
43Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.21273074
44Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.18028512
45Glycerophospholipid metabolism_Homo sapiens_hsa005641.15045260
46Pancreatic cancer_Homo sapiens_hsa052121.13980641
47Thyroid hormone signaling pathway_Homo sapiens_hsa049191.13737218
48Tryptophan metabolism_Homo sapiens_hsa003801.09508625
49Glutathione metabolism_Homo sapiens_hsa004801.07782712
50Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.07722762
51Butanoate metabolism_Homo sapiens_hsa006501.07695475
52Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.06142284
53Inositol phosphate metabolism_Homo sapiens_hsa005621.05781790
54Nitrogen metabolism_Homo sapiens_hsa009101.04702063
55Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.03591071
56Non-homologous end-joining_Homo sapiens_hsa034501.03177308
57Peroxisome_Homo sapiens_hsa041461.02600702
58DNA replication_Homo sapiens_hsa030301.00815842
59Huntingtons disease_Homo sapiens_hsa050161.00231853
60Bile secretion_Homo sapiens_hsa049760.96936864
61Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.95612194
62One carbon pool by folate_Homo sapiens_hsa006700.95590396
63Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.94490915
64Basal transcription factors_Homo sapiens_hsa030220.94435658
65Prion diseases_Homo sapiens_hsa050200.94217004
66Endometrial cancer_Homo sapiens_hsa052130.91457307
67Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.91008407
68RNA transport_Homo sapiens_hsa030130.89567587
69beta-Alanine metabolism_Homo sapiens_hsa004100.86071762
70Oocyte meiosis_Homo sapiens_hsa041140.85413034
71Chemical carcinogenesis_Homo sapiens_hsa052040.85338047
72Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.84222708
73Carbohydrate digestion and absorption_Homo sapiens_hsa049730.83448947
74Pentose and glucuronate interconversions_Homo sapiens_hsa000400.81238626
75Glioma_Homo sapiens_hsa052140.78998095
76mTOR signaling pathway_Homo sapiens_hsa041500.77824005
77Small cell lung cancer_Homo sapiens_hsa052220.77021478
78VEGF signaling pathway_Homo sapiens_hsa043700.76412983
79Homologous recombination_Homo sapiens_hsa034400.75749030
80Prostate cancer_Homo sapiens_hsa052150.75522322
81MicroRNAs in cancer_Homo sapiens_hsa052060.75096386
82Purine metabolism_Homo sapiens_hsa002300.73263078
83AMPK signaling pathway_Homo sapiens_hsa041520.72269390
84HIF-1 signaling pathway_Homo sapiens_hsa040660.71704329
85Adherens junction_Homo sapiens_hsa045200.71224613
86Metabolic pathways_Homo sapiens_hsa011000.70942689
87Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.70608810
88N-Glycan biosynthesis_Homo sapiens_hsa005100.70465064
89Parkinsons disease_Homo sapiens_hsa050120.70101679
90Cyanoamino acid metabolism_Homo sapiens_hsa004600.69638117
91Mismatch repair_Homo sapiens_hsa034300.68983298
92Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.67882121
93Oxidative phosphorylation_Homo sapiens_hsa001900.66025032
94Adipocytokine signaling pathway_Homo sapiens_hsa049200.65467139
95Arginine and proline metabolism_Homo sapiens_hsa003300.64644150
96Apoptosis_Homo sapiens_hsa042100.64236503
97Fanconi anemia pathway_Homo sapiens_hsa034600.63883035
98Fatty acid elongation_Homo sapiens_hsa000620.63773715
99Phenylalanine metabolism_Homo sapiens_hsa003600.62864304
100Pyrimidine metabolism_Homo sapiens_hsa002400.62624274
101Phosphatidylinositol signaling system_Homo sapiens_hsa040700.62113883
102Epstein-Barr virus infection_Homo sapiens_hsa051690.61809575
103Influenza A_Homo sapiens_hsa051640.60971969
104Central carbon metabolism in cancer_Homo sapiens_hsa052300.60926607
105Starch and sucrose metabolism_Homo sapiens_hsa005000.59782884
106mRNA surveillance pathway_Homo sapiens_hsa030150.59536906
107ErbB signaling pathway_Homo sapiens_hsa040120.58786929
108Endocytosis_Homo sapiens_hsa041440.57204818
109Drug metabolism - other enzymes_Homo sapiens_hsa009830.56801464
110ABC transporters_Homo sapiens_hsa020100.55488136
111Renal cell carcinoma_Homo sapiens_hsa052110.55384677
112Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.54437266
113Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.52674848
114Transcriptional misregulation in cancer_Homo sapiens_hsa052020.52611996
115* Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.52596142
116Proteoglycans in cancer_Homo sapiens_hsa052050.51781842
117Sulfur metabolism_Homo sapiens_hsa009200.51685410
118B cell receptor signaling pathway_Homo sapiens_hsa046620.51280750
119Colorectal cancer_Homo sapiens_hsa052100.51164905
120AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.50728811
121Longevity regulating pathway - mammal_Homo sapiens_hsa042110.50600861
122Galactose metabolism_Homo sapiens_hsa000520.49725228
123Estrogen signaling pathway_Homo sapiens_hsa049150.49247243
124Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.48983261
125Sulfur relay system_Homo sapiens_hsa041220.47778810
126Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.47754593
127Amphetamine addiction_Homo sapiens_hsa050310.46966717
128HTLV-I infection_Homo sapiens_hsa051660.46852037
129Tyrosine metabolism_Homo sapiens_hsa003500.46606259
130Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.46260497
131Hepatitis B_Homo sapiens_hsa051610.45850680
132Lysine degradation_Homo sapiens_hsa003100.45814531
133Type II diabetes mellitus_Homo sapiens_hsa049300.43271108
134Proteasome_Homo sapiens_hsa030500.42164144
135Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.41736310
136Legionellosis_Homo sapiens_hsa051340.39179538
137Alzheimers disease_Homo sapiens_hsa050100.38767452
138Focal adhesion_Homo sapiens_hsa045100.37598110
139Base excision repair_Homo sapiens_hsa034100.36008644
140Prolactin signaling pathway_Homo sapiens_hsa049170.34878450
141Neurotrophin signaling pathway_Homo sapiens_hsa047220.34715122
142Folate biosynthesis_Homo sapiens_hsa007900.34409645
143Mineral absorption_Homo sapiens_hsa049780.33892728
144Glycosaminoglycan degradation_Homo sapiens_hsa005310.33259547
145Hedgehog signaling pathway_Homo sapiens_hsa043400.32928458
146Insulin secretion_Homo sapiens_hsa049110.30240589
147Arachidonic acid metabolism_Homo sapiens_hsa005900.30092303
148Insulin signaling pathway_Homo sapiens_hsa049100.28777477
149Complement and coagulation cascades_Homo sapiens_hsa046100.28613467
150Thyroid hormone synthesis_Homo sapiens_hsa049180.27172446
151Insulin resistance_Homo sapiens_hsa049310.27103458
152Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.26616486
153Systemic lupus erythematosus_Homo sapiens_hsa053220.26343437
154Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.25597641

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