CLPS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a cofactor needed by pancreatic lipase for efficient dietary lipid hydrolysis. It binds to the C-terminal, non-catalytic domain of lipase, thereby stabilizing an active conformation and considerably increasing the overall hydrophobic binding site. The gene product allows lipase to anchor noncovalently to the surface of lipid micelles, counteracting the destabilizing influence of intestinal bile salts. This cofactor is only expressed in pancreatic acinar cells, suggesting regulation of expression by tissue-specific elements. Three transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of phospholipase A2 activity (GO:0032429)8.82255109
2negative regulation of epidermis development (GO:0045683)8.17511889
3intestinal absorption (GO:0050892)6.98576643
4peptidyl-proline hydroxylation (GO:0019511)6.97953679
5COPI coating of Golgi vesicle (GO:0048205)6.16061853
6Golgi transport vesicle coating (GO:0048200)6.16061853
7transcytosis (GO:0045056)6.10011212
8regulation of keratinocyte differentiation (GO:0045616)5.99749724
9sterol catabolic process (GO:0016127)5.83295048
10cholesterol catabolic process (GO:0006707)5.83295048
11regulation of keratinocyte proliferation (GO:0010837)5.71336011
12negative regulation of digestive system process (GO:0060457)5.64783901
13protein hydroxylation (GO:0018126)5.58989511
14neutrophil mediated immunity (GO:0002446)5.41895259
15intestinal epithelial cell development (GO:0060576)5.39891581
16leukotriene biosynthetic process (GO:0019370)5.25791065
17sphingolipid catabolic process (GO:0030149)4.83607399
18valine metabolic process (GO:0006573)4.77402421
19activation of signaling protein activity involved in unfolded protein response (GO:0006987)4.76782978
20branched-chain amino acid catabolic process (GO:0009083)4.71970699
21cholesterol transport (GO:0030301)4.68248948
22sterol transport (GO:0015918)4.68248948
23regulation of proton transport (GO:0010155)4.66671868
24membrane lipid catabolic process (GO:0046466)4.64320646
25antibacterial humoral response (GO:0019731)4.64219523
26glycolipid catabolic process (GO:0019377)4.62064816
27polyketide metabolic process (GO:0030638)4.57327557
28doxorubicin metabolic process (GO:0044598)4.57327557
29daunorubicin metabolic process (GO:0044597)4.57327557
30positive regulation of nuclease activity (GO:0032075)4.56238166
31cysteine metabolic process (GO:0006534)4.50477483
32phosphatidylcholine acyl-chain remodeling (GO:0036151)4.49743354
33proline biosynthetic process (GO:0006561)4.48294303
34digestive system process (GO:0022600)4.39897983
35icosanoid secretion (GO:0032309)4.36280932
36arachidonic acid secretion (GO:0050482)4.36280932
37antimicrobial humoral response (GO:0019730)4.31445302
38phosphatidic acid biosynthetic process (GO:0006654)4.26931015
39phosphatidic acid metabolic process (GO:0046473)4.26931015
40regulation of acrosome reaction (GO:0060046)4.23846253
41endoplasmic reticulum unfolded protein response (GO:0030968)4.19716127
42endocrine pancreas development (GO:0031018)4.19640566
43branched-chain amino acid metabolic process (GO:0009081)4.17062062
44response to endoplasmic reticulum stress (GO:0034976)4.16459021
45water-soluble vitamin metabolic process (GO:0006767)4.15999095
46regulation of cholesterol homeostasis (GO:2000188)4.14321243
47myeloid leukocyte mediated immunity (GO:0002444)4.13482473
48phosphatidylserine acyl-chain remodeling (GO:0036150)4.12949069
49regulation of nuclease activity (GO:0032069)4.12402840
50ceramide catabolic process (GO:0046514)4.08673025
51aminoglycoside antibiotic metabolic process (GO:0030647)4.08215204
52phosphatidylinositol acyl-chain remodeling (GO:0036149)4.08074915
53defense response to Gram-positive bacterium (GO:0050830)4.06350079
54cellular response to unfolded protein (GO:0034620)4.04635273
55atrioventricular valve morphogenesis (GO:0003181)3.99604547
56phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.93203092
57alditol phosphate metabolic process (GO:0052646)3.91657362
58ER-nucleus signaling pathway (GO:0006984)3.89009291
59maintenance of protein localization in organelle (GO:0072595)3.87960783
60acute-phase response (GO:0006953)3.83474041
61innate immune response in mucosa (GO:0002227)3.81470172
62cellular response to topologically incorrect protein (GO:0035967)3.81201648
63maintenance of gastrointestinal epithelium (GO:0030277)3.77831587
64positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.72815428
65mitochondrial calcium ion transport (GO:0006851)3.71169641
66fatty acid derivative transport (GO:1901571)3.66857233
67icosanoid transport (GO:0071715)3.66857233
68negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.65756974
69COPII vesicle coating (GO:0048208)3.62597987
70protein maturation by protein folding (GO:0022417)3.61351541
71cellular modified amino acid catabolic process (GO:0042219)3.56916696
72phospholipid catabolic process (GO:0009395)3.55616491
73retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.54522451
74cellular protein catabolic process (GO:0044257)3.54444652
754-hydroxyproline metabolic process (GO:0019471)3.53593934
76leukotriene metabolic process (GO:0006691)3.51218713
77tetrapyrrole metabolic process (GO:0033013)3.49327468
78signal peptide processing (GO:0006465)3.49054441
79regulation of epidermal cell differentiation (GO:0045604)3.44567580
80negative regulation of epithelial cell differentiation (GO:0030857)3.43367554
81zinc ion transport (GO:0006829)3.43096805
82polarized epithelial cell differentiation (GO:0030859)3.39672277
83phosphatidylglycerol metabolic process (GO:0046471)3.38352560
84growth hormone secretion (GO:0030252)3.36588456
85aspartate family amino acid catabolic process (GO:0009068)3.35199741
86multicellular organismal catabolic process (GO:0044243)3.35155397
87endothelial cell migration (GO:0043542)3.29300631
88positive regulation of growth hormone secretion (GO:0060124)3.28111295
89epithelial structure maintenance (GO:0010669)3.26609839
90protein autoprocessing (GO:0016540)3.24759008
91response to unfolded protein (GO:0006986)3.23236051
92mucosal immune response (GO:0002385)3.18682971
93homocysteine metabolic process (GO:0050667)3.17628968
94vitamin metabolic process (GO:0006766)3.14991876
95membrane repolarization during action potential (GO:0086011)3.14441260
96ER overload response (GO:0006983)3.09312252
97response to topologically incorrect protein (GO:0035966)3.09242512
98multicellular organismal metabolic process (GO:0044236)3.08978135
99steroid catabolic process (GO:0006706)3.08562340
100L-alpha-amino acid transmembrane transport (GO:1902475)3.07678765
101ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.07264367
102membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.03902203
103regulation of bile acid biosynthetic process (GO:0070857)3.03572760
104serine family amino acid biosynthetic process (GO:0009070)3.00712496
105lung secretory cell differentiation (GO:0061140)3.00147802
106cholesterol metabolic process (GO:0008203)3.00073243
107organ or tissue specific immune response (GO:0002251)2.99730492
108phosphatidylserine metabolic process (GO:0006658)2.99681017
109positive regulation of wound healing (GO:0090303)2.99435083
110phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.93121086
111regulation of oxidative stress-induced intrinsic apoptotic signaling pathway (GO:1902175)2.92198634
112insulin-like growth factor receptor signaling pathway (GO:0048009)2.91780929
113peptidyl-asparagine modification (GO:0018196)2.90905192
114protein N-linked glycosylation via asparagine (GO:0018279)2.90899072
115bundle of His cell to Purkinje myocyte communication (GO:0086069)2.90705885
116pancreas development (GO:0031016)2.89982635
117glutamine metabolic process (GO:0006541)2.88790289
118GDP-mannose metabolic process (GO:0019673)2.88383856
119O-glycan processing (GO:0016266)2.82905341
120pH reduction (GO:0045851)2.82821886
121long-chain fatty acid transport (GO:0015909)2.82336089
122proline metabolic process (GO:0006560)2.81925476
123regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.81566599
124sulfation (GO:0051923)2.80847400
125extracellular matrix disassembly (GO:0022617)2.79682254
126fatty acid derivative biosynthetic process (GO:1901570)2.76918476
127icosanoid biosynthetic process (GO:0046456)2.76918476
128acute inflammatory response (GO:0002526)2.73441515
129glandular epithelial cell differentiation (GO:0002067)2.73112371
130establishment of apical/basal cell polarity (GO:0035089)2.72467543
131mitochondrion distribution (GO:0048311)2.71706912
132sulfur amino acid catabolic process (GO:0000098)2.70287848
133sterol metabolic process (GO:0016125)2.69793090
134ventricular cardiac muscle cell action potential (GO:0086005)2.69644740
135nucleotide-sugar biosynthetic process (GO:0009226)2.58181264
136regulation of calcium ion import (GO:0090279)2.57558700
137positive regulation of calcium ion transport into cytosol (GO:0010524)2.54590670
138endocardial cushion morphogenesis (GO:0003203)2.50397570
139macroautophagy (GO:0016236)2.45943206
140alcohol catabolic process (GO:0046164)2.42488233
141epithelial cell migration (GO:0010631)2.41053496
142epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.39748826
143defense response to Gram-negative bacterium (GO:0050829)2.39737669
144negative regulation of hormone metabolic process (GO:0032351)2.35068635
145neutrophil chemotaxis (GO:0030593)2.30463538
146regulation of macrophage chemotaxis (GO:0010758)2.29322495
147positive regulation of fibroblast proliferation (GO:0048146)2.28529450
148calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.26301627
149neutrophil migration (GO:1990266)2.25091185
150progesterone metabolic process (GO:0042448)2.24531669
151acid secretion (GO:0046717)2.24331656
152exocrine pancreas development (GO:0031017)14.1679309
153intestinal cholesterol absorption (GO:0030299)13.8516498
154* digestion (GO:0007586)13.5666434
155protein retention in ER lumen (GO:0006621)11.5698461
156maintenance of protein localization in endoplasmic reticulum (GO:0035437)10.9372145
157cobalamin metabolic process (GO:0009235)10.8890938
158negative regulation of epidermal cell differentiation (GO:0045605)10.7191059

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_21828071_ChIP-Seq_BEAS2B_Human5.21165655
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.23643669
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.10476611
4* SOX2_27498859_Chip-Seq_STOMACH_Mouse4.01418472
5GATA4_25053715_ChIP-Seq_YYC3_Human2.99345742
6RARG_19884340_ChIP-ChIP_MEFs_Mouse2.67215439
7PPARA_22158963_ChIP-Seq_LIVER_Mouse2.66367377
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.63491221
9ESR1_21235772_ChIP-Seq_MCF-7_Human2.62009697
10GATA6_25053715_ChIP-Seq_YYC3_Human2.60701240
11CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.55007048
12ESR2_21235772_ChIP-Seq_MCF-7_Human2.53917066
13RXR_22158963_ChIP-Seq_LIVER_Mouse2.46284625
14LXR_22158963_ChIP-Seq_LIVER_Mouse2.41860257
15KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.40011173
16KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.40011173
17KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.40011173
18FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.34264741
19ERG_21242973_ChIP-ChIP_JURKAT_Human2.32327433
20ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.20451606
21FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.05471905
22PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.02526234
23TP63_17297297_ChIP-ChIP_HaCaT_Human1.97915613
24TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.95664589
25TCF4_18268006_ChIP-ChIP_LS174T_Human1.95168735
26PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.94333899
27HTT_18923047_ChIP-ChIP_STHdh_Human1.93973613
28GATA1_22025678_ChIP-Seq_K562_Human1.93889315
29* LXR_22292898_ChIP-Seq_THP-1_Human1.89362584
30CLOCK_20551151_ChIP-Seq_293T_Human1.69158797
31STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.67028010
32CREB1_26743006_Chip-Seq_LNCaP_Human1.64919528
33PPAR_26484153_Chip-Seq_NCI-H1993_Human1.62274647
34GATA1_26923725_Chip-Seq_HPCs_Mouse1.58121674
35SOX2_20726797_ChIP-Seq_SW620_Human1.55776059
36RACK7_27058665_Chip-Seq_MCF-7_Human1.55751344
37HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.55089729
38TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.51923222
39RUNX1_27514584_Chip-Seq_MCF-7_Human1.49958532
40CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.49012919
41FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.48475676
42ETV1_20927104_ChIP-Seq_GIST48_Human1.47012678
43MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.46996523
44ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.45830283
45KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.44826698
46TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44304663
47PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.42768268
48HNFA_21074721_ChIP-Seq_CACO-2_Human1.42660897
49ZNF217_24962896_ChIP-Seq_MCF-7_Human1.41860281
50ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.40756027
51FOXA2_19822575_ChIP-Seq_HepG2_Human1.40110746
52ATF3_27146783_Chip-Seq_COLON_Human1.39782565
53PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.39623020
54CDX2_20551321_ChIP-Seq_CACO-2_Human1.39491868
55PHF8_20622853_ChIP-Seq_HELA_Human1.39456846
56NFYA_21822215_ChIP-Seq_K562_Human1.38446833
57FOXO3_23340844_ChIP-Seq_DLD1_Human1.38128175
58KLF5_25053715_ChIP-Seq_YYC3_Human1.37806228
59AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.36975856
60CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.36831374
61TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.36018237
62P63_26484246_Chip-Seq_KERATINOCYTES_Human1.35766138
63PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.34921684
64E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.34671961
65SA1_27219007_Chip-Seq_ERYTHROID_Human1.33652514
66AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.31856141
67RBPJ_21746931_ChIP-Seq_IB4_Human1.31518775
68CHD1_26751641_Chip-Seq_LNCaP_Human1.31186671
69GATA6_21074721_ChIP-Seq_CACO-2_Human1.29999917
70GATA3_24758297_ChIP-Seq_MCF-7_Human1.29304796
71CBX2_22325352_ChIP-Seq_293T-Rex_Human1.28945531
72ESET_19884257_ChIP-Seq_ESCs_Mouse1.27943711
73FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.27667826
74GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.27606478
75KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.27241989
76SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.21113956
77KDM2B_26808549_Chip-Seq_K562_Human1.17654517
78SRY_22984422_ChIP-ChIP_TESTIS_Rat1.16971910
79NFYB_21822215_ChIP-Seq_K562_Human1.16376646
80TP63_22573176_ChIP-Seq_HFKS_Human1.16115266
81FOXA1_25552417_ChIP-Seq_VCAP_Human1.15485871
82TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.14500543
83JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13323064
84JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13306767
85FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.12770461
86DNAJC2_21179169_ChIP-ChIP_NT2_Human1.12531264
87IGF1R_20145208_ChIP-Seq_DFB_Human1.10621649
88TBX20_22328084_ChIP-Seq_HEART_Mouse1.10590400
89TBX20_22080862_ChIP-Seq_HEART_Mouse1.10590400
90* P68_20966046_ChIP-Seq_HELA_Human1.10168946
91CDX2_19796622_ChIP-Seq_MESCs_Mouse1.08023336
92PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.07508077
93GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.07354050
94BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.07197546
95KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.06594713
96TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.06308867
97FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.03538732
98FOXH1_21741376_ChIP-Seq_ESCs_Human1.02501153
99NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.02074870
100* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.01530617
101* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.01313879
102IRF8_22096565_ChIP-ChIP_GC-B_Human1.00831261
103FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.99908272
104* EGR1_19032775_ChIP-ChIP_M12_Human0.99411423
105FOXM1_26456572_ChIP-Seq_MCF-7_Human0.98623255
106* BCOR_27268052_Chip-Seq_Bcells_Human0.96059375
107CTCF_27219007_Chip-Seq_Bcells_Human0.95295133
108TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.95126024
109NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.93948694
110ZNF274_21170338_ChIP-Seq_K562_Hela0.93051787
111TBL1_22424771_ChIP-Seq_293T_Human0.92850952
112KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.91342072
113SALL4_18804426_ChIP-ChIP_XEN_Mouse0.89920843
114AHR_22903824_ChIP-Seq_MCF-7_Human0.89869115
115OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.89798688
116ELK3_25401928_ChIP-Seq_HUVEC_Human0.88545824
117CJUN_26792858_Chip-Seq_BT549_Human0.86020657
118NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.85005581
119P300_19829295_ChIP-Seq_ESCs_Human0.83894396
120SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.83201288
121GATA1_19941826_ChIP-Seq_K562_Human0.82477955
122CEBPB_22108803_ChIP-Seq_LS180_Human0.82165761
123FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.81399739
124SMAD4_21741376_ChIP-Seq_EPCs_Human0.81276638
125CDX2_22108803_ChIP-Seq_LS180_Human0.81274250
126NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.81181850
127ZFP281_18757296_ChIP-ChIP_E14_Mouse0.80960333
128CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.80570040
129ESR1_15608294_ChIP-ChIP_MCF-7_Human0.80527924
130CTCF_20526341_ChIP-Seq_ESCs_Human0.80435951
131MYC_22102868_ChIP-Seq_BL_Human0.79862679
132NFIB_24661679_ChIP-Seq_LUNG_Mouse0.79523997
133CBP_21632823_ChIP-Seq_H3396_Human0.78969455
134GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.78480768
135CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.78458780
136POU3F2_20337985_ChIP-ChIP_501MEL_Human0.78233856
137CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.77922312
138ELK4_26923725_Chip-Seq_MESODERM_Mouse0.77573934
139PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.76787740
140PIAS1_25552417_ChIP-Seq_VCAP_Human0.75360716
141TP53_18474530_ChIP-ChIP_U2OS_Human0.75028128
142ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.73716974
143SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.73351260
144SMAD_19615063_ChIP-ChIP_OVARY_Human0.71964065
145CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.70609459
146CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.68827586
147PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.66312672
148AR_20517297_ChIP-Seq_VCAP_Human0.66018529
149SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.65160512
150SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.65160512
151EP300_21415370_ChIP-Seq_HL-1_Mouse0.64807794
152RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.64442466
153FOXH1_21741376_ChIP-Seq_EPCs_Human0.64095964
154SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.62778299
155EGR1_23403033_ChIP-Seq_LIVER_Mouse0.62605002
156SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.62260304
157HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.61864305
158EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.61444309
159CTNNB1_20460455_ChIP-Seq_HCT116_Human0.59475983
160FOXA1_21572438_ChIP-Seq_LNCaP_Human0.58940010
161HNF4A_19822575_ChIP-Seq_HepG2_Human0.57935140

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008004_abnormal_stomach_pH8.76315609
2MP0005083_abnormal_biliary_tract8.67118893
3* MP0001666_abnormal_nutrient_absorption7.26538272
4MP0005220_abnormal_exocrine_pancreas5.17421675
5MP0005365_abnormal_bile_salt4.96183269
6MP0001664_abnormal_digestion4.14729107
7MP0005084_abnormal_gallbladder_morpholo4.13171779
8MP0005085_abnormal_gallbladder_physiolo3.18302258
9MP0000470_abnormal_stomach_morphology2.81966617
10* MP0003868_abnormal_feces_composition2.35667025
11MP0004264_abnormal_extraembryonic_tissu2.31204488
12MP0002693_abnormal_pancreas_physiology2.22530807
13MP0003283_abnormal_digestive_organ2.22255793
14MP0010234_abnormal_vibrissa_follicle2.21299310
15MP0001873_stomach_inflammation2.10319218
16MP0003705_abnormal_hypodermis_morpholog2.10287331
17MP0003959_abnormal_lean_body2.08625798
18MP0001944_abnormal_pancreas_morphology1.81081238
19MP0002139_abnormal_hepatobiliary_system1.79524959
20MP0006054_spinal_hemorrhage1.75618823
21MP0002138_abnormal_hepatobiliary_system1.62861563
22MP0003195_calcinosis1.50042403
23MP0003122_maternal_imprinting1.49549644
24MP0003806_abnormal_nucleotide_metabolis1.39899717
25MP0005165_increased_susceptibility_to1.36947724
26MP0003252_abnormal_bile_duct1.36475966
27MP0004233_abnormal_muscle_weight1.26963255
28MP0005448_abnormal_energy_balance1.23244445
29MP0008438_abnormal_cutaneous_collagen1.21177930
30MP0001502_abnormal_circadian_rhythm1.20977817
31MP0002163_abnormal_gland_morphology1.12997422
32MP0002132_abnormal_respiratory_system1.09292522
33MP0003123_paternal_imprinting1.04598927
34* MP0002118_abnormal_lipid_homeostasis1.04532264
35MP0009384_cardiac_valve_regurgitation1.03257319
36MP0002928_abnormal_bile_duct1.03214356
37MP0003638_abnormal_response/metabolism_1.03147906
38MP0010352_gastrointestinal_tract_polyps1.02045498
39MP0002078_abnormal_glucose_homeostasis0.98396734
40MP0001663_abnormal_digestive_system0.94227606
41MP0003011_delayed_dark_adaptation0.92900354
42MP0000003_abnormal_adipose_tissue0.91260147
43MP0005381_digestive/alimentary_phenotyp0.90789019
44MP0003953_abnormal_hormone_level0.87097847
45MP0000490_abnormal_crypts_of0.85006084
46MP0001501_abnormal_sleep_pattern0.84014069
47MP0002277_abnormal_respiratory_mucosa0.82659276
48MP0005332_abnormal_amino_acid0.81249481
49MP0008961_abnormal_basal_metabolism0.78787713
50MP0009840_abnormal_foam_cell0.75305039
51MP0005408_hypopigmentation0.73618084
52MP0005379_endocrine/exocrine_gland_phen0.71563185
53MP0009643_abnormal_urine_homeostasis0.71203514
54MP0002089_abnormal_postnatal_growth/wei0.69406936
55MP0000462_abnormal_digestive_system0.68375833
56MP0000613_abnormal_salivary_gland0.64709489
57MP0009780_abnormal_chondrocyte_physiolo0.64404303
58MP0000537_abnormal_urethra_morphology0.63521142
59MP0005451_abnormal_body_composition0.63500133
60MP0004272_abnormal_basement_membrane0.63105530
61MP0003119_abnormal_digestive_system0.62730696
62MP0004185_abnormal_adipocyte_glucose0.61921314
63MP0003950_abnormal_plasma_membrane0.59513831
64MP0003045_fibrosis0.56219533
65MP0002796_impaired_skin_barrier0.55458362
66MP0000598_abnormal_liver_morphology0.55327917
67MP0008995_early_reproductive_senescence0.53063256
68MP0003828_pulmonary_edema0.52917092
69MP0003866_abnormal_defecation0.52676500
70MP0003300_gastrointestinal_ulcer0.51212877
71MP0003879_abnormal_hair_cell0.50803806
72MP0000013_abnormal_adipose_tissue0.48766953
73MP0005334_abnormal_fat_pad0.48222174
74MP0002896_abnormal_bone_mineralization0.47649994
75MP0003186_abnormal_redox_activity0.46743607
76MP0002060_abnormal_skin_morphology0.46177084
77* MP0005452_abnormal_adipose_tissue0.45888159
78MP0009703_decreased_birth_body0.45820232
79MP0005375_adipose_tissue_phenotype0.45813297
80MP0000477_abnormal_intestine_morphology0.43412264
81MP0002168_other_aberrant_phenotype0.42825579
82MP0005535_abnormal_body_temperature0.41367533
83MP0005058_abnormal_lysosome_morphology0.41264393
84MP0000383_abnormal_hair_follicle0.40852819
85MP0002909_abnormal_adrenal_gland0.40392068
86MP0000609_abnormal_liver_physiology0.39594418
87MP0000858_altered_metastatic_potential0.39428438
88MP0002098_abnormal_vibrissa_morphology0.39268852
89MP0010678_abnormal_skin_adnexa0.38607464
90MP0008872_abnormal_physiological_respon0.38408103
91MP0009672_abnormal_birth_weight0.38332378
92MP0004019_abnormal_vitamin_homeostasis0.37945219
93MP0005319_abnormal_enzyme/_coenzyme0.36829074
94MP0001765_abnormal_ion_homeostasis0.36507076
95MP0000467_abnormal_esophagus_morphology0.36076070
96MP0004858_abnormal_nervous_system0.35708074
97* MP0009642_abnormal_blood_homeostasis0.33744625
98MP0004043_abnormal_pH_regulation0.33183939
99MP0001756_abnormal_urination0.32375308
100MP0001845_abnormal_inflammatory_respons0.31717344
101MP0003183_abnormal_peptide_metabolism0.31484262
102MP0003656_abnormal_erythrocyte_physiolo0.31357190
103MP0000377_abnormal_hair_follicle0.31291115
104MP0002970_abnormal_white_adipose0.31240217
105MP0003115_abnormal_respiratory_system0.31013416
106MP0000750_abnormal_muscle_regeneration0.30276719
107* MP0001731_abnormal_postnatal_growth0.29758010
108MP0001849_ear_inflammation0.29704258
109MP0003566_abnormal_cell_adhesion0.28565265
110MP0003436_decreased_susceptibility_to0.28234816
111MP0005636_abnormal_mineral_homeostasis0.28074021
112MP0005360_urolithiasis0.27911408
113MP0001243_abnormal_dermal_layer0.27605310
114MP0005166_decreased_susceptibility_to0.27563789
115MP0003941_abnormal_skin_development0.25882786
116MP0010155_abnormal_intestine_physiology0.25844328
117MP0003329_amyloid_beta_deposits0.25736344
118MP0005076_abnormal_cell_differentiation0.24923044
119MP0003943_abnormal_hepatobiliary_system0.24412407
120MP0000538_abnormal_urinary_bladder0.24180132
121MP0009765_abnormal_xenobiotic_induced0.24075498
122MP0004130_abnormal_muscle_cell0.23509758
123MP0005187_abnormal_penis_morphology0.23449304
124MP0005646_abnormal_pituitary_gland0.23344600
125MP0001270_distended_abdomen0.23096468
126MP0003795_abnormal_bone_structure0.22526486
127MP0009763_increased_sensitivity_to0.22449940
128MP0001784_abnormal_fluid_regulation0.22396813
129* MP0010329_abnormal_lipoprotein_level0.22110558
130MP0010386_abnormal_urinary_bladder0.22014717
131MP0004085_abnormal_heartbeat0.21680829
132MP0002876_abnormal_thyroid_physiology0.21634137
133MP0002234_abnormal_pharynx_morphology0.21350995
134MP0008875_abnormal_xenobiotic_pharmacok0.18446838
135MP0005395_other_phenotype0.18323398
136MP0002127_abnormal_cardiovascular_syste0.18319593
137MP0003221_abnormal_cardiomyocyte_apopto0.17823525
138MP0005621_abnormal_cell_physiology0.17670738
139MP0003091_abnormal_cell_migration0.17611822
140MP0004484_altered_response_of0.17609542
141MP0001851_eye_inflammation0.17033325
142* MP0003956_abnormal_body_size0.17008495
143MP0008469_abnormal_protein_level0.16993226

Predicted human phenotypes

RankGene SetZ-score
1Abnormal number of erythroid precursors (HP:0012131)8.36891276
2Abnormality of cells of the erythroid lineage (HP:0012130)7.59639612
3Steatorrhea (HP:0002570)6.60799310
4Gout (HP:0001997)6.45592111
5Fat malabsorption (HP:0002630)5.72613040
6Exocrine pancreatic insufficiency (HP:0001738)5.08787185
7Abnormal pancreas size (HP:0012094)4.56394478
8Megaloblastic anemia (HP:0001889)4.50354475
9Abnormality of the pleura (HP:0002103)4.44231648
10Decreased subcutaneous fat (HP:0001002)4.41274227
11Short chin (HP:0000331)4.24291394
12Abnormality of subcutaneous fat tissue (HP:0001001)4.07683568
13Ketoacidosis (HP:0001993)3.97592211
14Hypoproteinemia (HP:0003075)3.95094438
15Type I diabetes mellitus (HP:0100651)3.90313402
16Abnormality of the pancreatic islet cells (HP:0006476)3.89902061
17Abnormality of endocrine pancreas physiology (HP:0012093)3.89902061
18Abnormality of the vitamin B12 metabolism (HP:0004341)3.81416229
19Abnormality of vitamin B metabolism (HP:0004340)3.70213371
20Right ventricular cardiomyopathy (HP:0011663)3.59865897
21Ventricular fibrillation (HP:0001663)3.58166918
22Maternal diabetes (HP:0009800)3.55823512
23Ketosis (HP:0001946)3.50628919
24Pancreatitis (HP:0001733)3.47624900
25Tubulointerstitial fibrosis (HP:0005576)3.34279908
26Abnormality of the intrinsic pathway (HP:0010989)3.33050318
27Tubulointerstitial nephritis (HP:0001970)3.16938880
28Hypoplasia of the pons (HP:0012110)3.16917781
29Anal atresia (HP:0002023)3.13180413
30Hypoglycemic coma (HP:0001325)3.12918247
31Late onset (HP:0003584)3.07671403
32Abnormality of vitamin metabolism (HP:0100508)3.04836846
33Increased purine levels (HP:0004368)2.95471564
34Hyperuricemia (HP:0002149)2.95471564
35Tetraparesis (HP:0002273)2.90918960
36Abnormality of the pons (HP:0007361)2.86894608
37Vascular calcification (HP:0004934)2.83957663
38Joint stiffness (HP:0001387)2.75594062
39Hypotension (HP:0002615)2.73173771
40Abnormality of aromatic amino acid family metabolism (HP:0004338)2.69342602
41Hypoglycemic seizures (HP:0002173)2.62697623
42Hyperinsulinemic hypoglycemia (HP:0000825)2.60509458
43Male infertility (HP:0003251)2.58444525
44Cortical dysplasia (HP:0002539)2.52440850
45Cardiovascular calcification (HP:0011915)2.47950524
46Premature skin wrinkling (HP:0100678)2.46370783
47Hyperglycemia (HP:0003074)2.45104378
48Tubular atrophy (HP:0000092)2.44290340
49Ankyloglossia (HP:0010296)2.41801023
50Abnormality of methionine metabolism (HP:0010901)2.38695112
51Abnormality of the nasal septum (HP:0000419)2.32659241
52Popliteal pterygium (HP:0009756)2.31575651
53Ileus (HP:0002595)2.30976124
54Syncope (HP:0001279)2.25999644
55Prolonged QT interval (HP:0001657)2.22915772
56Congenital glaucoma (HP:0001087)2.21782624
57Rectal prolapse (HP:0002035)2.20971460
58Hyperglycinemia (HP:0002154)2.14781393
59Esophageal varix (HP:0002040)2.14015002
60Fatigue (HP:0012378)2.13364637
61Large for gestational age (HP:0001520)2.12940023
62Abnormal biliary tract morphology (HP:0012440)2.12609040
63Abnormality of the common coagulation pathway (HP:0010990)2.11891733
64Abnormal sex determination (HP:0012244)2.11088487
65Sex reversal (HP:0012245)2.11088487
66Abnormal tarsal ossification (HP:0008369)2.09543191
67Enlarged penis (HP:0000040)2.09473962
68Pancreatic islet-cell hyperplasia (HP:0004510)2.06294721
69Prenatal maternal abnormality (HP:0002686)2.05671192
70Abnormality of purine metabolism (HP:0004352)2.02219407
71Long foot (HP:0001833)2.01836695
72Macrocytic anemia (HP:0001972)2.01446035
73Hyperglycinuria (HP:0003108)1.99448331
74Fragile skin (HP:0001030)1.95933676
75Lymphangioma (HP:0100764)1.95767798
76Glomerulosclerosis (HP:0000096)1.95495926
77Pectus carinatum (HP:0000768)1.95162891
78Abnormality of the renal cortex (HP:0011035)1.94576058
79Atrophic scars (HP:0001075)1.94535258
80Testicular neoplasm (HP:0010788)1.94061218
81Hydroxyprolinuria (HP:0003080)1.93726233
82Abnormality of proline metabolism (HP:0010907)1.93726233
83Abnormality of aspartate family amino acid metabolism (HP:0010899)1.90084806
84Renal salt wasting (HP:0000127)1.87313051
85Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.83893190
86Carpal bone hypoplasia (HP:0001498)1.83003381
87Insulin resistance (HP:0000855)1.81439854
88Abnormality of glycine metabolism (HP:0010895)1.81332653
89Abnormality of serine family amino acid metabolism (HP:0010894)1.81332653
90Genetic anticipation (HP:0003743)1.78605138
91Type I transferrin isoform profile (HP:0003642)1.78541719
92Symptomatic seizures (HP:0011145)1.77794909
93Severe short stature (HP:0003510)1.76232132
94Congenital sensorineural hearing impairment (HP:0008527)1.76156716
95Abnormality of sulfur amino acid metabolism (HP:0004339)1.75631741
96Germ cell neoplasia (HP:0100728)1.75133268
97Abdominal pain (HP:0002027)1.74880365
98Abnormality of oral frenula (HP:0000190)1.73820869
99Conjugated hyperbilirubinemia (HP:0002908)1.72792720
100Periodontitis (HP:0000704)1.72641147
101Absent eyelashes (HP:0000561)1.71528419
102Asymmetry of the thorax (HP:0001555)1.71353570
103Dysostosis multiplex (HP:0000943)1.71122132
104Tubulointerstitial abnormality (HP:0001969)1.68401182
105Goiter (HP:0000853)1.66798156
106Palpitations (HP:0001962)1.66636893
107Villous atrophy (HP:0011473)1.66576663
108Abnormality of small intestinal villus morphology (HP:0011472)1.66576663
109Papillary thyroid carcinoma (HP:0002895)1.66257903
110Insulin-resistant diabetes mellitus (HP:0000831)1.64507439
111Flat acetabular roof (HP:0003180)1.63391468
112Micronodular cirrhosis (HP:0001413)1.63125491
113Abdominal distention (HP:0003270)1.63082256
114Intrahepatic cholestasis (HP:0001406)1.60802684
115Thin bony cortex (HP:0002753)1.60287278
116Progressive muscle weakness (HP:0003323)1.59844048
117Hyperphosphatemia (HP:0002905)1.59604798
118Thoracolumbar scoliosis (HP:0002944)1.59266287
119Turricephaly (HP:0000262)1.58822772
120Lower limb hyperreflexia (HP:0002395)1.57995537
121Abnormal foot bone ossification (HP:0010675)1.57733764
122Abnormality of dentin (HP:0010299)1.56956512
123Portal hypertension (HP:0001409)1.56639098
124Patent foramen ovale (HP:0001655)1.56151503
125Unilateral renal agenesis (HP:0000122)1.55292170
126Cortical visual impairment (HP:0100704)1.55255786
127Abnormal protein glycosylation (HP:0012346)1.55077081
128Abnormal glycosylation (HP:0012345)1.55077081
129Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.55077081
130Abnormal protein N-linked glycosylation (HP:0012347)1.55077081
131Double outlet right ventricle (HP:0001719)1.50364774
132Congenital malformation of the right heart (HP:0011723)1.50364774
133Reduced antithrombin III activity (HP:0001976)1.49947800
134Absent eyebrow (HP:0002223)1.48940540
135Hypoplastic labia majora (HP:0000059)1.48488324
136Abnormality of glutamine family amino acid metabolism (HP:0010902)1.47622687
137Periauricular skin pits (HP:0100277)1.45117703
138Preauricular pit (HP:0004467)1.45117703
139Facial shape deformation (HP:0011334)1.45102361
140Potter facies (HP:0002009)1.45102361
141Abnormality of urine glucose concentration (HP:0011016)1.42449786
142Glycosuria (HP:0003076)1.42449786
143Malnutrition (HP:0004395)1.41888517
144Azoospermia (HP:0000027)1.40661043
145Abnormality of the hepatic vasculature (HP:0006707)1.39478438
146Paraparesis (HP:0002385)1.39254593
147Abnormality of the right ventricle (HP:0001707)1.38529344
148Progressive cerebellar ataxia (HP:0002073)1.36442532
149Abnormality of chloride homeostasis (HP:0011422)1.35828463
150Skin pits (HP:0100276)1.35252203
151Axonal loss (HP:0003447)1.34599448
152Abnormality of the labia majora (HP:0012881)1.34484235
153Enlarged kidneys (HP:0000105)1.33791487
154Urethral obstruction (HP:0000796)1.33161135
155Arterial tortuosity (HP:0005116)1.29088178
156Anal stenosis (HP:0002025)1.28596994
157Vascular tortuosity (HP:0004948)1.25067164
158Gowers sign (HP:0003391)1.24580165
159Barrel-shaped chest (HP:0001552)1.23736957
160Type II lissencephaly (HP:0007260)1.21441235
161Neoplasm of the pancreas (HP:0002894)1.21243925
162EEG with generalized epileptiform discharges (HP:0011198)1.18490505
163Renal tubular acidosis (HP:0001947)1.18012736
164Hypsarrhythmia (HP:0002521)1.16116308
165Glossoptosis (HP:0000162)1.14663224
166Abnormality of the distal phalanges of the toes (HP:0010182)1.13304253

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.63501026
2TRIB34.97834461
3ERN14.68287193
4EPHA24.45832876
5PKN24.29409563
6MAP2K23.23241379
7EIF2AK33.07979279
8INSRR2.25236394
9PTK62.03091553
10FRK2.02248035
11ZAP701.99809131
12MST1R1.94472868
13GRK11.93129019
14IRAK11.90108243
15NTRK31.86636730
16TAOK31.86342627
17WNK41.77163429
18LRRK21.72928697
19EEF2K1.68690628
20PAK21.63477611
21LATS11.62519847
22PDGFRB1.57906085
23MAPK151.57045978
24NLK1.51157212
25MAP2K11.47111542
26MAP3K121.46033212
27MAP3K21.37781468
28RIPK11.36657496
29RPS6KB21.35961998
30PIK3CG1.35744238
31PRKG21.32957691
32MET1.31704474
33TRPM71.27012724
34MAPKAPK31.26721337
35SCYL21.25775687
36IRAK21.21850069
37PDGFRA1.21100794
38FLT31.19001261
39NME11.11108551
40MST41.10968974
41KSR21.08272065
42SGK31.05951436
43EIF2AK11.05780252
44SGK21.03438767
45CDK81.01515886
46FER1.00174491
47STK160.97408011
48PRKCI0.94323127
49SIK10.92558057
50CAMKK10.91876691
51NEK60.91513606
52NME20.91453571
53PTK20.90902993
54PRKD30.87944313
55PASK0.87611149
56RET0.87351168
57OXSR10.86395833
58BMPR1B0.85895106
59DDR20.85423502
60MELK0.83588330
61LMTK20.82659565
62MAP3K100.81313649
63EPHB10.78553209
64MTOR0.78290072
65PIM20.76673422
66IRAK30.76209855
67STK240.75451079
68FGFR40.75355064
69MAP3K50.74845774
70STK390.74480132
71ERBB40.73549389
72NTRK10.70242869
73SGK2230.70085655
74SGK4940.70085655
75DYRK1B0.69109195
76PIK3CA0.68284038
77NUAK10.67680097
78MAP3K10.66048866
79STK380.65220019
80ILK0.62067209
81PRKCE0.62040799
82PAK40.61394297
83PDK20.58289533
84STK38L0.57595092
85BRSK20.57588938
86PDPK10.53349771
87BCR0.53293053
88MYLK0.52988110
89DYRK1A0.49809574
90PRKCH0.48720524
91PRKAA10.48671609
92MAP2K60.48102358
93MAP4K20.47919372
94MAP3K90.47116055
95DAPK20.46498613
96EPHA30.45972104
97ROCK10.45278207
98ERBB30.42839606
99STK30.41404377
100CHUK0.40442361
101TESK10.39345193
102MAP3K140.38938283
103HIPK20.38896779
104AKT30.38414232
105PAK30.37551724
106MAP3K80.37349905
107PRKAA20.36038955
108MUSK0.35560877
109TGFBR20.35020608
110PRKD10.34474858
111RPS6KA10.34430879
112PDK10.34036812
113ICK0.32409982
114WNK10.31749655
115JAK10.31270561
116JAK20.30785007
117CAMK40.30635290
118KSR10.30557094
119PRKCZ0.30145015
120RPS6KA20.29869208
121FGFR30.29327118
122CDK90.28747542
123MAP3K30.28618932
124CDC42BPA0.28155175
125ERBB20.28108721
126TAOK10.28030670
127MAP3K70.27885137
128ACVR1B0.27728029
129TYRO30.27597325
130PRKACB0.27561309
131ADRBK20.25699280
132MATK0.25255188
133CSNK1G10.24457658
134CSNK1A10.23148940
135MAPK70.23041216
136MAPK30.22085709
137PRKD20.21291011
138IGF1R0.20638644
139MAPK10.20224441
140TNIK0.19293002
141RPS6KB10.19271938
142CSK0.18971050
143CSNK1E0.18940255
144CAMKK20.18673084
145EGFR0.17900293
146STK100.17289323
147MARK20.17276983
148ROCK20.16763902
149CDK190.16667453
150NEK90.16200204
151TBK10.15873381
152FGFR10.15438261
153CDK40.15377654
154MAPK120.15334532
155DAPK30.15057990
156SGK10.14943618
157GSK3A0.14908734
158PRKACA0.14764553
159TIE10.12873253

Predicted pathways (KEGG)

RankGene SetZ-score
1Pancreatic secretion_Homo sapiens_hsa049728.09797306
2* Fat digestion and absorption_Homo sapiens_hsa049755.49978734
3Protein digestion and absorption_Homo sapiens_hsa049745.31029867
4Maturity onset diabetes of the young_Homo sapiens_hsa049504.09562606
5Glycerolipid metabolism_Homo sapiens_hsa005612.94716964
6Vitamin digestion and absorption_Homo sapiens_hsa049772.75011383
7Collecting duct acid secretion_Homo sapiens_hsa049662.56855659
8Protein export_Homo sapiens_hsa030602.47245247
9Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.06998271
10Gastric acid secretion_Homo sapiens_hsa049712.05927877
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.03606853
12alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.02696003
13Linoleic acid metabolism_Homo sapiens_hsa005911.92841558
14Folate biosynthesis_Homo sapiens_hsa007901.79135721
15Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.57656730
16Steroid biosynthesis_Homo sapiens_hsa001001.46624497
17Propanoate metabolism_Homo sapiens_hsa006401.46219335
18Cyanoamino acid metabolism_Homo sapiens_hsa004601.41806793
19Sulfur metabolism_Homo sapiens_hsa009201.24357077
20Circadian rhythm_Homo sapiens_hsa047101.19028104
212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.14315885
22Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.07391518
23Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.01209425
24Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.94563429
25Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.91232863
26N-Glycan biosynthesis_Homo sapiens_hsa005100.89973513
27Insulin secretion_Homo sapiens_hsa049110.89606517
28Renin-angiotensin system_Homo sapiens_hsa046140.88603832
29Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.85657158
30Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.84255108
31Glutathione metabolism_Homo sapiens_hsa004800.84128680
32Ether lipid metabolism_Homo sapiens_hsa005650.83184785
33Fatty acid degradation_Homo sapiens_hsa000710.82228017
34Carbohydrate digestion and absorption_Homo sapiens_hsa049730.76388275
35Notch signaling pathway_Homo sapiens_hsa043300.74316269
36Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.72488166
37Chemical carcinogenesis_Homo sapiens_hsa052040.71834460
38Biosynthesis of amino acids_Homo sapiens_hsa012300.69283262
39Arginine and proline metabolism_Homo sapiens_hsa003300.69023123
40Starch and sucrose metabolism_Homo sapiens_hsa005000.68458498
41Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.63222664
42Selenocompound metabolism_Homo sapiens_hsa004500.60972675
43Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.58858458
44Arachidonic acid metabolism_Homo sapiens_hsa005900.58238917
45Vibrio cholerae infection_Homo sapiens_hsa051100.58021192
46beta-Alanine metabolism_Homo sapiens_hsa004100.57256293
47Influenza A_Homo sapiens_hsa051640.56594253
48Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.55867975
49Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.55707653
50Other glycan degradation_Homo sapiens_hsa005110.55314035
51Pentose and glucuronate interconversions_Homo sapiens_hsa000400.53339985
52Thyroid hormone synthesis_Homo sapiens_hsa049180.53335336
53Nitrogen metabolism_Homo sapiens_hsa009100.51852571
54Pyruvate metabolism_Homo sapiens_hsa006200.50997697
55Cysteine and methionine metabolism_Homo sapiens_hsa002700.45002256
56Tryptophan metabolism_Homo sapiens_hsa003800.41576018
57Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.38589714
58Bile secretion_Homo sapiens_hsa049760.38562811
59Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.36513445
60Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.36418405
61Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.35356356
62Steroid hormone biosynthesis_Homo sapiens_hsa001400.35047129
63Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.34437148
64Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.34115927
65Vitamin B6 metabolism_Homo sapiens_hsa007500.32274861
66Vascular smooth muscle contraction_Homo sapiens_hsa042700.32075297
67Histidine metabolism_Homo sapiens_hsa003400.31484280
68Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.30738858
69Carbon metabolism_Homo sapiens_hsa012000.30338277
70Oxidative phosphorylation_Homo sapiens_hsa001900.29158323
71Lysosome_Homo sapiens_hsa041420.29123839
72Tight junction_Homo sapiens_hsa045300.28305730
73Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.28174064
74Endometrial cancer_Homo sapiens_hsa052130.27862045
75Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.27731082
76Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.27426271
77Glycerophospholipid metabolism_Homo sapiens_hsa005640.25917640
78Jak-STAT signaling pathway_Homo sapiens_hsa046300.25276788
79Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.23153335
80Arginine biosynthesis_Homo sapiens_hsa002200.22885824
81VEGF signaling pathway_Homo sapiens_hsa043700.21957382
82Estrogen signaling pathway_Homo sapiens_hsa049150.21498730
83One carbon pool by folate_Homo sapiens_hsa006700.20152455
84Primary bile acid biosynthesis_Homo sapiens_hsa001200.19806319
85Butanoate metabolism_Homo sapiens_hsa006500.19783136
86Insulin resistance_Homo sapiens_hsa049310.19636580
87Bladder cancer_Homo sapiens_hsa052190.19485126
88Hepatitis C_Homo sapiens_hsa051600.17587285
89Mineral absorption_Homo sapiens_hsa049780.16940423
90Fatty acid metabolism_Homo sapiens_hsa012120.16036598
91Thyroid cancer_Homo sapiens_hsa052160.15551599
92Lysine degradation_Homo sapiens_hsa003100.15454407
93Phototransduction_Homo sapiens_hsa047440.15226499
94Fructose and mannose metabolism_Homo sapiens_hsa000510.13346523
95Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.13248992
96Metabolic pathways_Homo sapiens_hsa011000.12867949
97Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.12342934
98Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.12178651
99Legionellosis_Homo sapiens_hsa051340.12156560
100mTOR signaling pathway_Homo sapiens_hsa041500.11898230
101Sphingolipid metabolism_Homo sapiens_hsa006000.11371607
102Cocaine addiction_Homo sapiens_hsa050300.10026657
103Aldosterone synthesis and secretion_Homo sapiens_hsa049250.08592720
104Longevity regulating pathway - mammal_Homo sapiens_hsa042110.08228013
105Retinol metabolism_Homo sapiens_hsa008300.08032700
106Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.07167587
107Complement and coagulation cascades_Homo sapiens_hsa046100.06433779
108Type II diabetes mellitus_Homo sapiens_hsa049300.05507085
109ABC transporters_Homo sapiens_hsa020100.05448893
110Ras signaling pathway_Homo sapiens_hsa040140.05345293
111Adherens junction_Homo sapiens_hsa045200.05326680
112Prostate cancer_Homo sapiens_hsa052150.05300377
113Galactose metabolism_Homo sapiens_hsa000520.03479655
114TGF-beta signaling pathway_Homo sapiens_hsa043500.02958423
115FoxO signaling pathway_Homo sapiens_hsa040680.02057267
116Salivary secretion_Homo sapiens_hsa049700.01122810
117Cholinergic synapse_Homo sapiens_hsa047250.00423323
118Sulfur relay system_Homo sapiens_hsa041220.00264452
119Ovarian steroidogenesis_Homo sapiens_hsa049130.00200866
120Renal cell carcinoma_Homo sapiens_hsa05211-0.1370210
121Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960-0.1301773
122ErbB signaling pathway_Homo sapiens_hsa04012-0.1117654
123Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120-0.1106709
124Amphetamine addiction_Homo sapiens_hsa05031-0.1069884
125Dorso-ventral axis formation_Homo sapiens_hsa04320-0.1067004
126Hippo signaling pathway_Homo sapiens_hsa04390-0.0904599
127Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860-0.0872642
128Leukocyte transendothelial migration_Homo sapiens_hsa04670-0.0803113
129Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760-0.0734088
130SNARE interactions in vesicular transport_Homo sapiens_hsa04130-0.0461881
131Viral carcinogenesis_Homo sapiens_hsa05203-0.0375063
132Peroxisome_Homo sapiens_hsa04146-0.0363889
133TNF signaling pathway_Homo sapiens_hsa04668-0.0345688
134Regulation of autophagy_Homo sapiens_hsa04140-0.0069907
135Epstein-Barr virus infection_Homo sapiens_hsa05169-0.0044497

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