CLPSL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of chronic inflammatory response (GO:0002676)9.30455724
2serotonin receptor signaling pathway (GO:0007210)9.07048519
3single fertilization (GO:0007338)8.84313013
4tryptophan catabolic process (GO:0006569)8.83573474
5indole-containing compound catabolic process (GO:0042436)8.83573474
6indolalkylamine catabolic process (GO:0046218)8.83573474
7heterotypic cell-cell adhesion (GO:0034113)8.78978818
8positive regulation of hair follicle development (GO:0051798)8.57698096
9positive regulation of hair cycle (GO:0042635)8.57698096
10positive regulation of osteoblast proliferation (GO:0033690)7.76571587
11positive regulation of type 2 immune response (GO:0002830)7.62363351
12tryptophan metabolic process (GO:0006568)7.58328558
13negative regulation of interleukin-10 production (GO:0032693)7.49191432
14regulation of Cdc42 GTPase activity (GO:0043088)7.30612304
15regulation of appetite (GO:0032098)7.14918448
16angiogenesis involved in wound healing (GO:0060055)7.12070950
17negative regulation of calcium ion transport into cytosol (GO:0010523)7.03327635
18negative regulation of circadian rhythm (GO:0042754)6.66605267
19interferon-gamma production (GO:0032609)6.08348386
20aromatic amino acid family catabolic process (GO:0009074)6.00779053
21glycoprotein catabolic process (GO:0006516)5.89102757
22fertilization (GO:0009566)5.85655840
23hematopoietic stem cell proliferation (GO:0071425)5.82793014
24cellular biogenic amine catabolic process (GO:0042402)5.80089905
25amine catabolic process (GO:0009310)5.80089905
26regulation of hair follicle development (GO:0051797)5.76104961
27protein K63-linked deubiquitination (GO:0070536)5.67068680
28indolalkylamine metabolic process (GO:0006586)5.56300583
29protein K48-linked deubiquitination (GO:0071108)5.42054722
30lymphangiogenesis (GO:0001946)5.39903825
31activated T cell proliferation (GO:0050798)5.34309857
32negative regulation of interleukin-8 production (GO:0032717)5.34275193
33paraxial mesoderm development (GO:0048339)5.26839129
34homocysteine metabolic process (GO:0050667)5.12670533
35sulfation (GO:0051923)5.09721501
36mucosal immune response (GO:0002385)5.02299491
37glycerophospholipid catabolic process (GO:0046475)4.99234914
38benzene-containing compound metabolic process (GO:0042537)4.91240799
39granulocyte differentiation (GO:0030851)4.80381637
40killing of cells of other organism (GO:0031640)4.74664039
41disruption of cells of other organism (GO:0044364)4.74664039
42omega-hydroxylase P450 pathway (GO:0097267)4.73173232
43carnitine transmembrane transport (GO:1902603)4.58690652
44organ or tissue specific immune response (GO:0002251)4.54102522
45thyroid hormone metabolic process (GO:0042403)4.50561107
46negative regulation of T cell apoptotic process (GO:0070233)4.49288056
47epithelial cell morphogenesis (GO:0003382)4.46663205
48carnitine metabolic process (GO:0009437)4.46557485
49negative regulation of endopeptidase activity (GO:0010951)4.42096940
50positive regulation of cell-cell adhesion (GO:0022409)4.41276014
51aromatic amino acid family metabolic process (GO:0009072)4.37503080
52filopodium assembly (GO:0046847)4.36655583
53maturation of 5.8S rRNA (GO:0000460)4.28644416
54organic cation transport (GO:0015695)4.27801244
55protein-cofactor linkage (GO:0018065)4.23207225
56negative regulation of peptidase activity (GO:0010466)4.22264923
57carnitine transport (GO:0015879)4.20222084
58amino-acid betaine transport (GO:0015838)4.20222084
59positive regulation of epidermis development (GO:0045684)4.10906260
60protein sumoylation (GO:0016925)4.07760884
61transepithelial transport (GO:0070633)4.04163665
62negative regulation of metanephros development (GO:0072217)4.00353339
63indole-containing compound metabolic process (GO:0042430)3.95706936
64regulation of type 2 immune response (GO:0002828)3.95244011
65spindle assembly involved in mitosis (GO:0090307)3.91314267
66heparan sulfate proteoglycan metabolic process (GO:0030201)3.90297217
67regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.80094698
68nuclear pore organization (GO:0006999)3.79753341
69phospholipid translocation (GO:0045332)3.78309220
70lipid translocation (GO:0034204)3.78309220
71regulation of clathrin-mediated endocytosis (GO:2000369)3.72322490
72regulation of hair cycle (GO:0042634)3.72076723
73reverse cholesterol transport (GO:0043691)3.68841899
74DNA double-strand break processing (GO:0000729)3.66205665
75N-acetylneuraminate metabolic process (GO:0006054)3.64263761
76defense response to fungus (GO:0050832)3.63931271
77sulfur amino acid catabolic process (GO:0000098)3.63138934
78defense response to bacterium (GO:0042742)3.63024877
79androgen biosynthetic process (GO:0006702)3.54869297
80pseudouridine synthesis (GO:0001522)3.45358199
81righting reflex (GO:0060013)3.45291217
82sex differentiation (GO:0007548)3.43117744
83negative regulation of protein autophosphorylation (GO:0031953)3.41718513
84negative regulation of hormone biosynthetic process (GO:0032353)3.41472506
85negative regulation by host of viral transcription (GO:0043922)3.40882939
86startle response (GO:0001964)3.37233816
87protein K6-linked ubiquitination (GO:0085020)3.34830662
88skin development (GO:0043588)3.34477862
89negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.32673294
90flavonoid metabolic process (GO:0009812)3.30998313
91biotin metabolic process (GO:0006768)3.30581434
92regulation of osteoblast proliferation (GO:0033688)3.29952234
93amino-acid betaine metabolic process (GO:0006577)3.28149374
94negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.26806913
95negative regulation of calcium ion-dependent exocytosis (GO:0045955)3.25185812
96mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.24160999
97myoblast migration (GO:0051451)3.23947044
98replication fork processing (GO:0031297)3.21076333
99phospholipid homeostasis (GO:0055091)3.20563416
100positive regulation of cAMP-mediated signaling (GO:0043950)3.19238985
101serine family amino acid biosynthetic process (GO:0009070)3.17987737
102quaternary ammonium group transport (GO:0015697)3.17574465
1033-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.15918791
104purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.15918791
105cell killing (GO:0001906)3.15114505
106response to bacterium (GO:0009617)3.13520932
107regulation of macrophage activation (GO:0043030)3.12365639
108diaphragm development (GO:0060539)3.08511614
109intra-S DNA damage checkpoint (GO:0031573)3.06814028
110fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.06805229
111negative regulation of hormone metabolic process (GO:0032351)3.04696165
112regulation of B cell receptor signaling pathway (GO:0050855)3.03988853
113axon ensheathment in central nervous system (GO:0032291)3.02609814
114central nervous system myelination (GO:0022010)3.02609814
115alpha-linolenic acid metabolic process (GO:0036109)3.01309701
116phosphatidylinositol acyl-chain remodeling (GO:0036149)3.01189846
117reflex (GO:0060004)3.00497168
118regulation of steroid hormone biosynthetic process (GO:0090030)3.00390927
119seminiferous tubule development (GO:0072520)25.6325766
120detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.99829519
121triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.99810884
122neuron fate determination (GO:0048664)2.98968442
123regulation of lipoprotein metabolic process (GO:0050746)2.98868079
124neuromuscular process controlling posture (GO:0050884)2.93245236
125regulation of sarcomere organization (GO:0060297)2.92652947
126endothelial cell proliferation (GO:0001935)2.92449363
127microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.92179201
128ribonucleoside bisphosphate metabolic process (GO:0033875)2.92090531
129nucleoside bisphosphate metabolic process (GO:0033865)2.92090531
130purine nucleoside bisphosphate metabolic process (GO:0034032)2.92090531
131rRNA catabolic process (GO:0016075)2.90402359
132negative regulation of proteolysis (GO:0045861)2.88150360
133branched-chain amino acid catabolic process (GO:0009083)2.84859881
134phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.83901956
135regulation of transmission of nerve impulse (GO:0051969)2.78376465
136O-glycan processing (GO:0016266)2.77480699
137negative regulation of protein processing (GO:0010955)2.77416800
138negative regulation of protein maturation (GO:1903318)2.77416800
139sialylation (GO:0097503)2.77156095
140cysteine metabolic process (GO:0006534)2.76988354
141regulation of activated T cell proliferation (GO:0046006)2.75690014
142glial cell proliferation (GO:0014009)2.75122729
143negative regulation of lymphocyte apoptotic process (GO:0070229)2.73547902
144negative regulation of glycogen biosynthetic process (GO:0045719)2.71124010
145low-density lipoprotein particle clearance (GO:0034383)2.71119524
146positive regulation of interleukin-12 production (GO:0032735)2.70797025
147regulation of beta-amyloid formation (GO:1902003)2.69954192
148complement activation, alternative pathway (GO:0006957)2.66673910
149high-density lipoprotein particle remodeling (GO:0034375)2.65086724
150columnar/cuboidal epithelial cell development (GO:0002066)2.64558138
151positive regulation of cellular amide metabolic process (GO:0034250)2.59280506
152negative regulation of hydrolase activity (GO:0051346)2.57167746
153hormone catabolic process (GO:0042447)2.46938881
154negative regulation of receptor-mediated endocytosis (GO:0048261)2.44429544
155negative regulation of glycogen metabolic process (GO:0070874)2.43982741
156regulation of amyloid precursor protein catabolic process (GO:1902991)2.40640617
157regulation of endopeptidase activity (GO:0052548)2.38223406
158alpha-amino acid catabolic process (GO:1901606)2.34545254
159negative regulation of interleukin-6 production (GO:0032715)2.31810454
160L-serine transport (GO:0015825)2.29878414
161valine metabolic process (GO:0006573)2.28526341
162pyrimidine ribonucleoside catabolic process (GO:0046133)2.28327395
163regulation of T cell apoptotic process (GO:0070232)2.27604893
164cellular amino acid catabolic process (GO:0009063)2.27496098
165regulation of peptidase activity (GO:0052547)2.26188183
166response to misfolded protein (GO:0051788)2.23374086
167erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.21330508
168L-phenylalanine catabolic process (GO:0006559)2.21330508
169triglyceride catabolic process (GO:0019433)2.20868256
170regulation of interleukin-10 production (GO:0032653)2.19507316
171positive regulation of cholesterol transport (GO:0032376)2.14641934
172positive regulation of sterol transport (GO:0032373)2.14641934
173regulation of reproductive process (GO:2000241)2.14430135
174neutral lipid catabolic process (GO:0046461)2.13661472
175acylglycerol catabolic process (GO:0046464)2.13661472
176plasma lipoprotein particle remodeling (GO:0034369)2.12889186
177protein-lipid complex remodeling (GO:0034368)2.12889186
178macromolecular complex remodeling (GO:0034367)2.12889186
179serine transport (GO:0032329)2.09839211
180cellular anion homeostasis (GO:0030002)2.07697460
181negative regulation of T cell proliferation (GO:0042130)2.07410216
182cellular modified amino acid catabolic process (GO:0042219)2.05962657
183myelin maintenance (GO:0043217)2.04887193
184glutamate metabolic process (GO:0006536)2.02621498
185cellular response to epidermal growth factor stimulus (GO:0071364)2.01746066
186anterior/posterior axis specification, embryo (GO:0008595)2.01061569
187protein K11-linked deubiquitination (GO:0035871)14.8204880
188production of molecular mediator involved in inflammatory response (GO:0002532)14.5965019
189regulation of T cell tolerance induction (GO:0002664)14.5963884
190positive regulation of tolerance induction (GO:0002645)12.5072413
191sperm capacitation (GO:0048240)11.4519418
192regulation of tolerance induction (GO:0002643)10.8851669
193kynurenine metabolic process (GO:0070189)10.7530222
194negative regulation of tumor necrosis factor production (GO:0032720)1.99539015
195erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)1.98339462
196L-phenylalanine metabolic process (GO:0006558)1.98339462

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human5.72296479
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.87861572
3MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human4.79305182
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human4.31803804
5ESR1_20079471_ChIP-ChIP_T-47D_Human4.08974488
6IKZF1_21737484_ChIP-ChIP_HCT116_Human4.03485140
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.96847808
8AR_21572438_ChIP-Seq_LNCaP_Human3.25801143
9PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.00691257
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.83506752
11CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.75617985
12TAF15_26573619_Chip-Seq_HEK293_Human2.69483965
13DCP1A_22483619_ChIP-Seq_HELA_Human2.68394099
14ESR1_21235772_ChIP-Seq_MCF-7_Human2.56394013
15ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.53220368
16BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.46704356
17SMAD_19615063_ChIP-ChIP_OVARY_Human2.39579139
18ZNF263_19887448_ChIP-Seq_K562_Human2.37835887
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.34015388
20ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.31967684
21DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.30072311
22RXR_22158963_ChIP-Seq_LIVER_Mouse2.25856514
23E2F7_22180533_ChIP-Seq_HELA_Human2.23698732
24LXR_22158963_ChIP-Seq_LIVER_Mouse2.23198111
25IGF1R_20145208_ChIP-Seq_DFB_Human2.19864221
26JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.17348539
27LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse2.14110739
28THAP11_20581084_ChIP-Seq_MESCs_Mouse2.12082773
29DNAJC2_21179169_ChIP-ChIP_NT2_Human2.10238690
30ESR2_21235772_ChIP-Seq_MCF-7_Human2.10086071
31CREB1_15753290_ChIP-ChIP_HEK293T_Human2.09728630
32TRIM28_21343339_ChIP-Seq_HEK293_Human2.07790018
33SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse2.07789220
34RBPJ_22232070_ChIP-Seq_NCS_Mouse1.92741863
35E2F1_21310950_ChIP-Seq_MCF-7_Human1.90223360
36GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.84356182
37GATA3_21867929_ChIP-Seq_TH1_Mouse1.82771118
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.82364175
39PPARA_22158963_ChIP-Seq_LIVER_Mouse1.81056646
40CLOCK_20551151_ChIP-Seq_293T_Human1.80647008
41PCGF2_27294783_Chip-Seq_ESCs_Mouse1.80608250
42MYC_18940864_ChIP-ChIP_HL60_Human1.78002890
43SMAD1_18555785_Chip-Seq_ESCs_Mouse1.77120468
44POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.76573426
45EGR1_23403033_ChIP-Seq_LIVER_Mouse1.75218393
46PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.72120471
47NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.70673064
48MYC_18555785_ChIP-Seq_MESCs_Mouse1.67684674
49TET1_21451524_ChIP-Seq_MESCs_Mouse1.67190986
50HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.65269865
51PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.63960749
52TTF2_22483619_ChIP-Seq_HELA_Human1.61059660
53ER_23166858_ChIP-Seq_MCF-7_Human1.59170658
54TP53_22573176_ChIP-Seq_HFKS_Human1.57506741
55SUZ12_27294783_Chip-Seq_NPCs_Mouse1.57269093
56TP53_16413492_ChIP-PET_HCT116_Human1.55437313
57STAT1_17558387_ChIP-Seq_HELA_Human1.54776331
58SMAD4_21741376_ChIP-Seq_HESCs_Human1.54681054
59AR_25329375_ChIP-Seq_VCAP_Human1.53869531
60FLI1_21867929_ChIP-Seq_CD8_Mouse1.53688988
61FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.53568006
62REST_19997604_ChIP-ChIP_NEURONS_Mouse1.53191596
63E2F4_17652178_ChIP-ChIP_JURKAT_Human1.52193522
64SOX2_22085726_ChIP-Seq_NPCs_Mouse1.52086603
65EZH2_18974828_ChIP-Seq_MESCs_Mouse1.51638207
66RNF2_18974828_ChIP-Seq_MESCs_Mouse1.51638207
67ESRRB_18555785_Chip-Seq_ESCs_Mouse1.51408576
68GABP_17652178_ChIP-ChIP_JURKAT_Human1.51101293
69FOXP3_21729870_ChIP-Seq_TREG_Human1.50848722
70CDX2_19796622_ChIP-Seq_MESCs_Mouse1.49233156
71EST1_17652178_ChIP-ChIP_JURKAT_Human1.46094685
72GATA3_21878914_ChIP-Seq_MCF-7_Human1.46047088
73RAD21_21589869_ChIP-Seq_MESCs_Mouse1.45733727
74KDM5A_27292631_Chip-Seq_BREAST_Human1.41131071
75CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.40012583
76EWS_26573619_Chip-Seq_HEK293_Human1.39602344
77HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.39328469
78SMAD3_21741376_ChIP-Seq_HESCs_Human1.38382357
79SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.37822833
80MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.35788656
81PHF8_20622853_ChIP-Seq_HELA_Human1.33258563
82SOX3_22085726_ChIP-Seq_MUSCLE_Mouse1.31394528
83STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.31276411
84FOXA1_21572438_ChIP-Seq_LNCaP_Human1.30289977
85TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.27495993
86CTCF_18555785_Chip-Seq_ESCs_Mouse1.27242770
87GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.26898446
88ETS1_20019798_ChIP-Seq_JURKAT_Human1.26645390
89CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26459197
90SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.25434673
91MYC_18358816_ChIP-ChIP_MESCs_Mouse1.25390861
92ELF1_20517297_ChIP-Seq_JURKAT_Human1.24987187
93LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.24425690
94EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.24262957
95E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.24023604
96P68_20966046_ChIP-Seq_HELA_Human1.23948018
97HIF1A_21447827_ChIP-Seq_MCF-7_Human1.23385905
98NFE2_27457419_Chip-Seq_LIVER_Mouse1.22234451
99KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.19974412
100NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.19068287
101JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.18660868
102PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.18243816
103SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.16200449
104BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human1.15090265
105MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.14569834
106MYC_27129775_Chip-Seq_CORNEA_Mouse1.14533603
107SMC4_20622854_ChIP-Seq_HELA_Human1.13313237
108PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.13168827
109RACK7_27058665_Chip-Seq_MCF-7_Human1.12028763
110VDR_24787735_ChIP-Seq_THP-1_Human1.11448256
111ERG_20517297_ChIP-Seq_VCAP_Human1.10795261
112OCT4_21477851_ChIP-Seq_ESCs_Mouse1.10325109
113MYC_19915707_ChIP-ChIP_AK7_Human1.08996969
114CBX2_27304074_Chip-Seq_ESCs_Mouse1.08603884
115SOX9_24532713_ChIP-Seq_HFSC_Mouse1.07127669
116VDR_23849224_ChIP-Seq_CD4+_Human1.06763935
117FUS_26573619_Chip-Seq_HEK293_Human1.06265362
118BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.06122448
119SALL4_22934838_ChIP-ChIP_CD34+_Human1.06119463
120STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.05246660
121KAP1_22055183_ChIP-Seq_ESCs_Mouse1.04822836
122ERA_21632823_ChIP-Seq_H3396_Human1.04802569
123UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.04640843
124KDM2B_26808549_Chip-Seq_REH_Human1.04330600
125NOTCH1_21737748_ChIP-Seq_TLL_Human1.03789158
126FLI1_21867929_ChIP-Seq_TH2_Mouse1.03126445
127FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02689335
128TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.01234737
129CRX_20693478_ChIP-Seq_RETINA_Mouse1.01152447
130IRF1_19129219_ChIP-ChIP_H3396_Human1.01136964
131MTF2_20144788_ChIP-Seq_MESCs_Mouse1.00854391
132RBPJ_21746931_ChIP-Seq_IB4_Human1.00601971
133SMAD4_21741376_ChIP-Seq_EPCs_Human1.00426873
134SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.00351328
135ELK4_26923725_Chip-Seq_MESODERM_Mouse1.00251997
136FOXH1_21741376_ChIP-Seq_ESCs_Human0.98320551
137ZNF274_21170338_ChIP-Seq_K562_Hela0.98317978
138ERG_21242973_ChIP-ChIP_JURKAT_Human0.97981347
139EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.97970264
140EZH2_27294783_Chip-Seq_NPCs_Mouse0.97885439
141SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.97680254
142SOX2_18555785_Chip-Seq_ESCs_Mouse0.97632247
143GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.97357857
144REST_18959480_ChIP-ChIP_MESCs_Mouse0.97298409
145BCL6_27268052_Chip-Seq_Bcells_Human0.97248124
146SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.96459758
147TP53_20018659_ChIP-ChIP_R1E_Mouse0.95693017
148GATA1_26923725_Chip-Seq_HPCs_Mouse0.95688357
149SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.95639158
150SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.95352091
151NR3C1_23031785_ChIP-Seq_PC12_Mouse0.95304469
152ETS1_21867929_ChIP-Seq_TH2_Mouse0.95166201
153GATA6_21074721_ChIP-Seq_CACO-2_Human0.94822322
154P300_19829295_ChIP-Seq_ESCs_Human0.94499709
155IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.94170251
156CBP_20019798_ChIP-Seq_JUKART_Human0.94170251
157DROSHA_22980978_ChIP-Seq_HELA_Human0.93785153
158CTCF_20526341_ChIP-Seq_ESCs_Human0.93295917
159ZNF217_24962896_ChIP-Seq_MCF-7_Human0.92448298
160NELFA_20434984_ChIP-Seq_ESCs_Mouse0.92175148
161JUN_21703547_ChIP-Seq_K562_Human0.92136475
162RUNX1_27457419_Chip-Seq_LIVER_Mouse0.91975810
163CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.91894121
164WDR5_24793694_ChIP-Seq_LNCAP_Human0.91878754
165EZH2_27304074_Chip-Seq_ESCs_Mouse0.91561654
166BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.91362683
167FOXA1_27270436_Chip-Seq_PROSTATE_Human0.91126908
168FOXA1_25329375_ChIP-Seq_VCAP_Human0.91126908
169E2F1_17053090_ChIP-ChIP_MCF-7_Human0.89408657
170P300_27268052_Chip-Seq_Bcells_Human0.88819932
171SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.88792123
172FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.88704159
173STAT1_20625510_ChIP-Seq_HELA_Human0.88595300
174PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.88372869
175BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.88173931
176FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.88126998
177SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.87854680
178LXR_22292898_ChIP-Seq_THP-1_Human0.87583095
179HNFA_21074721_ChIP-Seq_CACO-2_Human0.86949539
180CTBP2_25329375_ChIP-Seq_LNCAP_Human0.86897831
181MYC_19079543_ChIP-ChIP_MESCs_Mouse0.86726929
182SRF_21415370_ChIP-Seq_HL-1_Mouse0.86497190
183HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.86420714
184KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.86383414
185ESR1_15608294_ChIP-ChIP_MCF-7_Human0.85847726
186KDM2B_26808549_Chip-Seq_K562_Human0.84791060
187PADI4_21655091_ChIP-ChIP_MCF-7_Human0.84753324
188BCOR_27268052_Chip-Seq_Bcells_Human0.83801304
189RAC3_21632823_ChIP-Seq_H3396_Human0.83563037
190RARA_24833708_ChIP-Seq_LIVER_Mouse0.82637543
191PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.82443170
192HTT_18923047_ChIP-ChIP_STHdh_Human0.82334732
193NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.82162850
194OCT4_20526341_ChIP-Seq_ESCs_Human0.80522051

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003183_abnormal_peptide_metabolism7.38907029
2MP0003303_peritoneal_inflammation5.81496019
3MP0003195_calcinosis5.37131896
4MP0002254_reproductive_system_inflammat5.14928046
5MP0004043_abnormal_pH_regulation4.89619780
6MP0002138_abnormal_hepatobiliary_system4.24917359
7MP0005310_abnormal_salivary_gland4.22964554
8MP0010234_abnormal_vibrissa_follicle4.19432470
9MP0002139_abnormal_hepatobiliary_system4.18632477
10MP0005410_abnormal_fertilization3.45615806
11MP0005058_abnormal_lysosome_morphology3.35993096
12MP0001984_abnormal_olfaction3.20150550
13MP0006292_abnormal_olfactory_placode3.13637680
14MP0003329_amyloid_beta_deposits3.02823488
15MP0001919_abnormal_reproductive_system2.89576235
16MP0002168_other_aberrant_phenotype2.24278372
17MP0000003_abnormal_adipose_tissue2.22778783
18MP0005389_reproductive_system_phenotype2.21423213
19MP0005360_urolithiasis2.21029334
20MP0005647_abnormal_sex_gland2.12094790
21MP0010329_abnormal_lipoprotein_level2.09151992
22MP0000613_abnormal_salivary_gland2.06260554
23MP0000604_amyloidosis2.02597133
24MP0005365_abnormal_bile_salt1.91145513
25MP0003566_abnormal_cell_adhesion1.82244593
26MP0005377_hearing/vestibular/ear_phenot1.79440315
27MP0003878_abnormal_ear_physiology1.79440315
28MP0004885_abnormal_endolymph1.71563874
29MP0001346_abnormal_lacrimal_gland1.70658546
30MP0003693_abnormal_embryo_hatching1.69994563
31MP0001764_abnormal_homeostasis1.65630084
32MP0005085_abnormal_gallbladder_physiolo1.65106263
33MP0005187_abnormal_penis_morphology1.64617400
34MP0002970_abnormal_white_adipose1.63204415
35MP0003300_gastrointestinal_ulcer1.60410093
36MP0001348_abnormal_lacrimal_gland1.58585926
37MP0001765_abnormal_ion_homeostasis1.57595826
38MP0001873_stomach_inflammation1.57500404
39MP0001853_heart_inflammation1.57172482
40MP0001501_abnormal_sleep_pattern1.56798321
41MP0003315_abnormal_perineum_morphology1.56567796
42MP0006276_abnormal_autonomic_nervous1.56159375
43MP0005375_adipose_tissue_phenotype1.55857439
44MP0001440_abnormal_grooming_behavior1.55483522
45MP0004130_abnormal_muscle_cell1.52527196
46MP0002277_abnormal_respiratory_mucosa1.49030795
47MP0001879_abnormal_lymphatic_vessel1.48752795
48MP0002006_tumorigenesis1.48415524
49MP0005551_abnormal_eye_electrophysiolog1.47403040
50MP0004859_abnormal_synaptic_plasticity1.46615039
51MP0002736_abnormal_nociception_after1.45219018
52MP0003690_abnormal_glial_cell1.43922419
53MP0002837_dystrophic_cardiac_calcinosis1.40936266
54MP0000534_abnormal_ureter_morphology1.36629570
55MP0005084_abnormal_gallbladder_morpholo1.36171770
56MP0009643_abnormal_urine_homeostasis1.35493724
57MP0002234_abnormal_pharynx_morphology1.35111000
58MP0009046_muscle_twitch1.33525711
59MP0004957_abnormal_blastocyst_morpholog1.32245423
60MP0005332_abnormal_amino_acid1.29476629
61MP0002089_abnormal_postnatal_growth/wei1.27997849
62MP0004185_abnormal_adipocyte_glucose1.27937967
63MP0004858_abnormal_nervous_system1.26313319
64MP0003718_maternal_effect1.25836899
65MP0003806_abnormal_nucleotide_metabolis1.22330873
66MP0005083_abnormal_biliary_tract1.21771688
67MP0003705_abnormal_hypodermis_morpholog1.19989590
68MP0002118_abnormal_lipid_homeostasis1.19505626
69MP0000537_abnormal_urethra_morphology1.17222458
70MP0010094_abnormal_chromosome_stability1.17214865
71MP0002090_abnormal_vision1.16948664
72MP0003638_abnormal_response/metabolism_1.16839345
73MP0009697_abnormal_copulation1.15674761
74MP0001905_abnormal_dopamine_level1.13142286
75MP0005584_abnormal_enzyme/coenzyme_acti1.12362732
76MP0001756_abnormal_urination1.11545657
77MP0003936_abnormal_reproductive_system1.11389631
78MP0008438_abnormal_cutaneous_collagen1.10875597
79MP0006082_CNS_inflammation1.08425640
80MP0000230_abnormal_systemic_arterial1.08019527
81MP0004036_abnormal_muscle_relaxation1.07852012
82MP0002796_impaired_skin_barrier1.04383571
83MP0003136_yellow_coat_color1.04079386
84MP0002896_abnormal_bone_mineralization1.03115318
85MP0005275_abnormal_skin_tensile1.03040345
86MP0009745_abnormal_behavioral_response1.02690299
87MP0003698_abnormal_male_reproductive1.01012643
88MP0002160_abnormal_reproductive_system1.00923062
89MP0003191_abnormal_cellular_cholesterol1.00876223
90MP0005636_abnormal_mineral_homeostasis1.00684539
91MP0003632_abnormal_nervous_system0.99628558
92MP0002735_abnormal_chemical_nociception0.98547112
93MP0000920_abnormal_myelination0.97921206
94MP0003075_altered_response_to0.97260020
95MP0004270_analgesia0.96724304
96MP0002928_abnormal_bile_duct0.96013838
97MP0001968_abnormal_touch/_nociception0.95019261
98MP0005666_abnormal_adipose_tissue0.94973984
99MP0002733_abnormal_thermal_nociception0.93908866
100MP0003879_abnormal_hair_cell0.92483918
101MP0003252_abnormal_bile_duct0.91947397
102MP0002127_abnormal_cardiovascular_syste0.86721687
103MP0008875_abnormal_xenobiotic_pharmacok0.86480570
104MP0005395_other_phenotype0.86413213
105MP0002269_muscular_atrophy0.85798236
106MP0000631_abnormal_neuroendocrine_gland0.85257251
107MP0002136_abnormal_kidney_physiology0.83597027
108MP0004142_abnormal_muscle_tone0.83318285
109MP0006035_abnormal_mitochondrial_morpho0.83142907
110MP0000383_abnormal_hair_follicle0.82532056
111MP0002909_abnormal_adrenal_gland0.82185908
112MP0002876_abnormal_thyroid_physiology0.82174794
113MP0009780_abnormal_chondrocyte_physiolo0.81722989
114MP0004145_abnormal_muscle_electrophysio0.80551759
115MP0003631_nervous_system_phenotype0.79857159
116MP0000747_muscle_weakness0.79214522
117MP0000609_abnormal_liver_physiology0.76043716
118MP0002933_joint_inflammation0.75500568
119MP0005670_abnormal_white_adipose0.75448802
120MP0002210_abnormal_sex_determination0.75102612
121MP0003633_abnormal_nervous_system0.74691593
122MP0000372_irregular_coat_pigmentation0.73863599
123MP0003635_abnormal_synaptic_transmissio0.72774397
124MP0000462_abnormal_digestive_system0.72488307
125MP0000639_abnormal_adrenal_gland0.70662449
126MP0000538_abnormal_urinary_bladder0.69930667
127MP0005319_abnormal_enzyme/_coenzyme0.69625581
128MP0009840_abnormal_foam_cell0.69618923
129MP0000627_abnormal_mammary_gland0.68288349
130MP0001970_abnormal_pain_threshold0.66306421
131MP0003634_abnormal_glial_cell0.66196680
132MP0005452_abnormal_adipose_tissue0.65080478
133MP0005595_abnormal_vascular_smooth0.64473643
134MP0005334_abnormal_fat_pad0.63490843
135MP0010678_abnormal_skin_adnexa0.63403613
136MP0003941_abnormal_skin_development0.62228682
137MP0002653_abnormal_ependyma_morphology0.62033728
138MP0000249_abnormal_blood_vessel0.61230526
139MP0002295_abnormal_pulmonary_circulatio0.60987408
140MP0001486_abnormal_startle_reflex0.60962748
141MP0002272_abnormal_nervous_system0.60472632
142MP0000678_abnormal_parathyroid_gland0.59941585
143MP0005623_abnormal_meninges_morphology0.59659843
144MP0001666_abnormal_nutrient_absorption0.59463066
145MP0002572_abnormal_emotion/affect_behav0.59395827
146MP0001529_abnormal_vocalization0.57793275
147MP0009053_abnormal_anal_canal0.57527330
148MP0005535_abnormal_body_temperature0.57216637
149MP0000762_abnormal_tongue_morphology0.56460549
150MP0002161_abnormal_fertility/fecundity0.56413214
151MP0009384_cardiac_valve_regurgitation0.56361265
152MP0008961_abnormal_basal_metabolism0.56251302
153MP0008873_increased_physiological_sensi0.56126125
154MP0002971_abnormal_brown_adipose0.55898224
155MP0005167_abnormal_blood-brain_barrier0.55556130
156MP0005166_decreased_susceptibility_to0.54811140
157MP0002064_seizures0.54538072
158MP0001145_abnormal_male_reproductive0.54069092
159MP0001299_abnormal_eye_distance/0.54065810
160MP0000653_abnormal_sex_gland0.53978705
161MP0004147_increased_porphyrin_level0.53333364
162MP0005174_abnormal_tail_pigmentation0.53259165
163MP0008058_abnormal_DNA_repair0.52819331
164MP0002734_abnormal_mechanical_nocicepti0.52380693
165MP0000751_myopathy0.51875996
166MP0000049_abnormal_middle_ear0.50423961
167MP0001929_abnormal_gametogenesis0.50220356
168MP0000647_abnormal_sebaceous_gland0.50000886
169MP0004264_abnormal_extraembryonic_tissu0.48289595
170MP0001324_abnormal_eye_pigmentation0.47859978
171MP0010386_abnormal_urinary_bladder0.47139563
172MP0001177_atelectasis0.47078835
173MP0002098_abnormal_vibrissa_morphology0.46241011
174MP0000371_diluted_coat_color0.46222557
175MP0003091_abnormal_cell_migration0.46139458
176MP0005164_abnormal_response_to0.45991458
177MP0003186_abnormal_redox_activity0.45915578
178MP0008569_lethality_at_weaning0.45420044
179MP0004272_abnormal_basement_membrane0.45310125
180MP0004087_abnormal_muscle_fiber0.45141063

Predicted human phenotypes

RankGene SetZ-score
1Myocardial infarction (HP:0001658)5.50390637
2Lower limb hyperreflexia (HP:0002395)5.32661558
3Hypophosphatemic rickets (HP:0004912)5.27411683
4Congenital sensorineural hearing impairment (HP:0008527)5.21406737
5Facial shape deformation (HP:0011334)4.87206826
6Potter facies (HP:0002009)4.87206826
7Retrobulbar optic neuritis (HP:0100654)4.83018264
8Optic neuritis (HP:0100653)4.83018264
9Vascular calcification (HP:0004934)4.82645640
10Complement deficiency (HP:0004431)4.67357938
11Bilateral sensorineural hearing impairment (HP:0008619)4.60998054
12Cardiovascular calcification (HP:0011915)4.48154795
13Hypoplasia of the uterus (HP:0000013)4.47331124
14Keratoconjunctivitis (HP:0001096)4.39014016
15Neurofibrillary tangles (HP:0002185)4.37323119
16Poikiloderma (HP:0001029)4.32920711
17Cerebral inclusion bodies (HP:0100314)4.20366511
18Orchitis (HP:0100796)4.16910758
19Malnutrition (HP:0004395)4.10742836
20Abnormal pancreas size (HP:0012094)3.98007815
21Choroideremia (HP:0001139)3.88505337
22Enlarged penis (HP:0000040)3.79091971
23Decreased circulating renin level (HP:0003351)3.74637251
24Unilateral renal agenesis (HP:0000122)3.65353051
25True hermaphroditism (HP:0010459)3.55034259
26Abolished electroretinogram (ERG) (HP:0000550)3.53213050
27Aplasia/hypoplasia of the uterus (HP:0008684)3.47851605
28Neoplasm of the heart (HP:0100544)3.47249701
29Abnormal number of erythroid precursors (HP:0012131)3.43608977
30Widely patent fontanelles and sutures (HP:0004492)3.43293482
31Abnormality of complement system (HP:0005339)3.37736970
32Recurrent gram-negative bacterial infections (HP:0005420)3.34867314
33Abnormality of the pericardium (HP:0001697)3.30140937
34Tinnitus (HP:0000360)3.27278604
35Supranuclear gaze palsy (HP:0000605)3.26824002
36Rickets (HP:0002748)3.21907434
37Keratoconjunctivitis sicca (HP:0001097)3.21725190
38Infantile muscular hypotonia (HP:0008947)3.21718324
39Intention tremor (HP:0002080)3.17684570
40Attenuation of retinal blood vessels (HP:0007843)3.14913324
41Xanthomatosis (HP:0000991)3.13200383
42Male pseudohermaphroditism (HP:0000037)3.12112297
43Decreased electroretinogram (ERG) amplitude (HP:0000654)3.10400862
44Choreoathetosis (HP:0001266)3.08156513
45Myositis (HP:0100614)3.07129730
46Bicornuate uterus (HP:0000813)2.99779595
47Deep venous thrombosis (HP:0002625)2.99485426
48Abnormality of cells of the erythroid lineage (HP:0012130)2.97838294
49Abnormality of the fovea (HP:0000493)2.95257944
50Agitation (HP:0000713)2.92571687
51Acute encephalopathy (HP:0006846)2.92509742
52CNS demyelination (HP:0007305)2.79245786
53Hemiplegia (HP:0002301)2.75729363
54Pancreatic cysts (HP:0001737)2.75509125
55Congenital stationary night blindness (HP:0007642)2.75432910
56Abnormality of dentin (HP:0010299)2.75076404
57Hepatocellular necrosis (HP:0001404)2.73630836
58Breast carcinoma (HP:0003002)2.70280867
59Hyperuricemia (HP:0002149)2.67473301
60Increased purine levels (HP:0004368)2.67473301
61Late onset (HP:0003584)2.65280195
62Ketoacidosis (HP:0001993)2.62392814
63Opisthotonus (HP:0002179)2.60336757
64Preaxial foot polydactyly (HP:0001841)2.56925113
65Hypopigmentation of the fundus (HP:0007894)2.54493288
66Intrahepatic cholestasis (HP:0001406)2.53490585
67Testicular atrophy (HP:0000029)2.53071446
68Pancreatic fibrosis (HP:0100732)2.48899837
69Vacuolated lymphocytes (HP:0001922)2.48615696
70Polar cataract (HP:0010696)2.46320163
71Hyperglycinuria (HP:0003108)2.45817257
72Ketosis (HP:0001946)2.41787118
73Difficulty running (HP:0009046)2.39403465
74Multiple enchondromatosis (HP:0005701)2.37936117
75Acute necrotizing encephalopathy (HP:0006965)2.37713690
76Hemorrhage of the eye (HP:0011885)2.34671395
77Gout (HP:0001997)2.33919903
78Anorexia (HP:0002039)2.33106717
79Peripheral hypomyelination (HP:0007182)2.32989593
80Acanthosis nigricans (HP:0000956)2.31257558
81Gonadotropin excess (HP:0000837)2.29136512
82Hepatic necrosis (HP:0002605)2.28498046
83Amelogenesis imperfecta (HP:0000705)2.28008773
84Skin nodule (HP:0200036)2.27882511
85Abnormality of aromatic amino acid family metabolism (HP:0004338)2.27689892
86Abnormal rod and cone electroretinograms (HP:0008323)2.27202427
87Spastic tetraparesis (HP:0001285)2.24751575
88Ileus (HP:0002595)2.24374941
89Abnormality of dental color (HP:0011073)2.24035793
90Abnormal hemoglobin (HP:0011902)2.22906563
91Abnormal mitochondria in muscle tissue (HP:0008316)2.20796054
92Osteomalacia (HP:0002749)2.20394435
93Bilateral microphthalmos (HP:0007633)2.20383545
94Aplasia/Hypoplasia of the uvula (HP:0010293)2.17390076
95Abnormality of purine metabolism (HP:0004352)2.17273909
96Limb hypertonia (HP:0002509)2.16205024
97Hyporeflexia of lower limbs (HP:0002600)2.16175356
98Delayed puberty (HP:0000823)2.15368241
99Aplasia/Hypoplasia of the tibia (HP:0005772)2.14885029
100Meckel diverticulum (HP:0002245)2.14319885
101Abnormality of serine family amino acid metabolism (HP:0010894)2.12061380
102Abnormality of glycine metabolism (HP:0010895)2.12061380
103Epidermoid cyst (HP:0200040)2.08700846
104Abnormality of the ileum (HP:0001549)2.07226730
105Ulnar claw (HP:0001178)2.06817169
106Hyperlipoproteinemia (HP:0010980)2.06629547
107Cerebral edema (HP:0002181)2.05975914
108Gait ataxia (HP:0002066)2.04937587
109Focal segmental glomerulosclerosis (HP:0000097)2.04917946
110Clumsiness (HP:0002312)2.04278146
111Mitochondrial inheritance (HP:0001427)2.04054448
112Increased neuronal autofluorescent lipopigment (HP:0002074)2.02350240
113Abnormality of the left ventricular outflow tract (HP:0011103)2.01993881
114Subaortic stenosis (HP:0001682)2.01993881
115Myokymia (HP:0002411)2.01958762
116Abnormality of the dental pulp (HP:0006479)2.00846949
117Hypoplastic left heart (HP:0004383)2.00051571
118Hyperparathyroidism (HP:0000843)1.99226133
119Segmental peripheral demyelination/remyelination (HP:0003481)1.99021019
120Muscle fiber splitting (HP:0003555)1.97867988
121Right ventricular cardiomyopathy (HP:0011663)1.95637829
122Wide cranial sutures (HP:0010537)1.95633524
123Mesangial abnormality (HP:0001966)1.94897008
124Hypoalphalipoproteinemia (HP:0003233)1.94253963
125Dysostosis multiplex (HP:0000943)1.94203370
126Anomalous pulmonary venous return (HP:0010772)1.93329444
127Absent radius (HP:0003974)1.93315763
128Basal ganglia calcification (HP:0002135)1.93213684
129Increased CSF lactate (HP:0002490)1.93054701
130Loss of speech (HP:0002371)1.92525197
131Spastic diplegia (HP:0001264)1.91762255
132Hepatoblastoma (HP:0002884)1.91144182
133Increased connective tissue (HP:0009025)1.90593591
134Bony spicule pigmentary retinopathy (HP:0007737)1.90460190
135Hypertriglyceridemia (HP:0002155)1.90079069
136Hypokinesia (HP:0002375)1.89538946
137Hyperphosphatemia (HP:0002905)1.88993758
138Thin bony cortex (HP:0002753)1.88100332
139Hyperammonemia (HP:0001987)1.87656709
140Turricephaly (HP:0000262)1.87612539
141Abnormal lung lobation (HP:0002101)1.87479455
142Chromosomal breakage induced by crosslinking agents (HP:0003221)1.87257676
143Systemic lupus erythematosus (HP:0002725)1.86838539
144Increased CSF protein (HP:0002922)1.85789383
145Aplasia/Hypoplasia of the spleen (HP:0010451)1.84674065
146Pili torti (HP:0003777)1.84400878
147Constricted visual fields (HP:0001133)1.83956641
148Hyperventilation (HP:0002883)1.83654111
149Prominent nose (HP:0000448)1.83231334
150Hypophosphatemia (HP:0002148)1.82857594
151Spastic paraplegia (HP:0001258)1.82121679
152Polydipsia (HP:0001959)1.81986189
153Abnormal drinking behavior (HP:0030082)1.81986189
154Gastrointestinal dysmotility (HP:0002579)1.80914471
155Aplasia involving forearm bones (HP:0009822)1.80589600
156Absent forearm bone (HP:0003953)1.80589600
157Hyperaldosteronism (HP:0000859)1.80563309
158Bicuspid aortic valve (HP:0001647)1.79920065
159Ectopia lentis (HP:0001083)1.79266268
160Progressive neurologic deterioration (HP:0002344)1.78751988
161Restlessness (HP:0000711)1.77750156
162Abnormality of monocarboxylic acid metabolism (HP:0010996)1.77734719
163Acne (HP:0001061)1.77565525
164Glomerulosclerosis (HP:0000096)1.76951358
165Glucose intolerance (HP:0000833)1.76899529
166Hyperkalemia (HP:0002153)1.76681888
167Pancreatitis (HP:0001733)1.76422416
168Abnormality of abdominal situs (HP:0011620)1.76113512
169Abdominal situs inversus (HP:0003363)1.76113512
170Aplasia/Hypoplasia of the tongue (HP:0010295)1.75801126
171Abnormality of sulfur amino acid metabolism (HP:0004339)1.75699713
172Unsteady gait (HP:0002317)1.75476925
173Optic nerve hypoplasia (HP:0000609)1.75306977
174Hyperactive renin-angiotensin system (HP:0000841)1.75297933
175Progressive macrocephaly (HP:0004481)1.75108866
176Degeneration of the lateral corticospinal tracts (HP:0002314)1.74430271
177Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.74430271
178Calf muscle hypertrophy (HP:0008981)1.72361768
179Hyperglycinemia (HP:0002154)1.70366657
180Psychosis (HP:0000709)1.69245558
181Abnormality of the periventricular white matter (HP:0002518)1.64935262
182Asymmetric septal hypertrophy (HP:0001670)1.62707855
183Oligomenorrhea (HP:0000876)1.62202537
184Tubulointerstitial fibrosis (HP:0005576)1.59982441
185Subcapsular cataract (HP:0000523)1.58700952
186Amyloidosis (HP:0011034)1.58397327
187Abnormal cartilage morphology (HP:0002763)1.57866782
188Abnormality of the Achilles tendon (HP:0005109)1.56074970
189Peripheral demyelination (HP:0011096)1.55905246
190Mucopolysacchariduria (HP:0008155)1.55310018
191Urinary glycosaminoglycan excretion (HP:0003541)1.55310018
192Abnormality of small intestinal villus morphology (HP:0011472)1.54593537

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK37.60352647
2MST44.49788225
3TXK4.42025813
4PINK13.46551068
5LMTK23.16897158
6ERN13.13745782
7EPHB12.90328350
8BUB12.70669764
9BLK2.66371470
10ZAK2.58198898
11SIK12.58090434
12FGFR22.38661919
13MAPKAPK32.29751841
14LRRK22.26695467
15YES12.24985409
16PKN22.24649721
17PDGFRA2.14798240
18FER2.11645162
19TRIB32.03377823
20STK391.92350157
21TAOK31.90884495
22FGFR41.86408195
23WNK41.79781859
24NTRK11.73746380
25PRKD31.72564504
26NME11.70224239
27EPHA21.65187738
28NME21.57016283
29EIF2AK31.52890619
30CDK121.49131701
31PBK1.46785159
32NTRK31.46100337
33PTK61.43506409
34MAP3K21.42680493
35PAK31.40427467
36TNK21.39222982
37MAPKAPK51.36258910
38NEK11.34492905
39IRAK11.32495190
40TYRO31.30140427
41TTN1.27610266
42PTK2B1.24719954
43RET1.21531477
44RIPK41.21058101
45PAK61.20349986
46PTK21.17613774
47TTK1.12319646
48INSR1.11785814
49RPS6KB21.11260141
50CHEK21.10876840
51TLK11.10372182
52MAP2K41.07174873
53CDK191.06254302
54BCKDK1.06133380
55MYLK1.05497157
56STK101.05416396
57ICK1.05159772
58VRK21.03599087
59LATS21.02386918
60PRKCH1.00806968
61ADRBK20.98951626
62STK38L0.98668843
63OXSR10.98542561
64GRK10.96259236
65NTRK20.96093816
66CASK0.94860923
67SCYL20.92950050
68FRK0.92339791
69EIF2AK20.91740090
70MAP3K70.90590215
71TESK10.90442208
72MAP3K60.89299173
73DYRK20.88385496
74EPHA40.87165864
75KSR20.86030283
76EPHB20.85429801
77ALK0.85348386
78PLK40.84720057
79CAMK1G0.83960669
80FGFR30.83290605
81CDK50.81118922
82PAK20.78061747
83AKT30.76675352
84DDR20.74633062
85DMPK0.74145670
86PAK40.72732050
87PRKCG0.70381109
88SIK20.69892505
89CDC70.69746224
90LATS10.69106287
91PHKG10.68631098
92PHKG20.68631098
93GSK3A0.68281903
94STK380.66754065
95WNK10.65979795
96MAP2K10.65687542
97RPS6KA50.65187860
98PDK40.62547342
99PDK30.62547342
100MINK10.61750542
101STK160.61450866
102ROCK20.61183981
103JAK20.60971933
104CSNK1E0.59544915
105FGFR10.59384102
106PRKCZ0.58879953
107SRC0.58840439
108UHMK10.58694625
109MAP3K120.58499556
110PRKACG0.58015549
111PLK10.57064512
112PIK3CA0.56957036
113PRKD10.56814593
114LIMK10.55660859
115FYN0.54573355
116CAMK1D0.53497237
117EEF2K0.52649786
118FLT30.51077731
119MARK10.50867695
120EGFR0.50610869
121MET0.49885382
122ERBB20.49314371
123MKNK10.49304757
124FES0.49282084
125PDGFRB0.49089187
126DAPK20.48536435
127CDK60.47859587
128TIE10.47731458
129CSK0.46312598
130PDK10.45534495
131IGF1R0.45508188
132TRPM70.43647138
133PDPK10.43460321
134WEE10.43176989
135DAPK30.40938331
136AURKA0.40582402
137PRKCQ0.40059700
138JAK10.38811060
139MAP3K130.38799695
140GRK50.38607452
141MAPK130.36909576
142MAP3K90.36198780
143VRK10.36186160
144PRKCA0.35623587
145ADRBK10.33983924
146PRKG10.30917553
147NEK20.29823198
148PRKCB0.29455159
149MAP3K80.29366798
150CSNK1A10.28043679
151STK240.27771682
152MUSK0.27423425
153MAPK110.27094421
154ATR0.25713965
155ABL20.25243312
156NUAK10.24656167
157PRKCI0.24597226
158GRK70.23838962
159CSNK2A10.22640368
160PLK30.21407971
161SRPK10.21028905
162CAMK10.20745801
163IKBKB0.19300442
164RPS6KA40.18856119
165PIM20.18828759
166TNIK0.18582494
167CDK30.18175550
168PRKACA0.18104412
169CAMK2A0.17577122
170CDK80.17521595
171MAP2K20.17176161
172NEK60.16750612
173GSK3B0.16712210
174PAK10.16652884
175TSSK60.16552171
176MAPK140.15940117
177CDK10.15004942
178RPS6KA60.14183576
179PASK0.12935771

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009105.23288672
2Glycosaminoglycan degradation_Homo sapiens_hsa005314.75835134
3Proteasome_Homo sapiens_hsa030504.43533452
4Glutathione metabolism_Homo sapiens_hsa004804.41634731
5Selenocompound metabolism_Homo sapiens_hsa004503.87785686
6Arachidonic acid metabolism_Homo sapiens_hsa005903.62141821
7Tryptophan metabolism_Homo sapiens_hsa003803.57360922
8Thyroid hormone synthesis_Homo sapiens_hsa049183.44621174
9African trypanosomiasis_Homo sapiens_hsa051433.39004716
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.04498449
11Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.75508231
12Oxidative phosphorylation_Homo sapiens_hsa001902.36346103
13Ribosome_Homo sapiens_hsa030102.14810339
14Parkinsons disease_Homo sapiens_hsa050122.10139863
15Fatty acid degradation_Homo sapiens_hsa000712.01243269
16Fatty acid metabolism_Homo sapiens_hsa012122.00164727
17Sulfur metabolism_Homo sapiens_hsa009201.95635652
18DNA replication_Homo sapiens_hsa030301.94320055
19Homologous recombination_Homo sapiens_hsa034401.89562956
20Arginine biosynthesis_Homo sapiens_hsa002201.86482570
21Linoleic acid metabolism_Homo sapiens_hsa005911.85735023
22RNA polymerase_Homo sapiens_hsa030201.84877392
23Huntingtons disease_Homo sapiens_hsa050161.79279583
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.76462042
25PPAR signaling pathway_Homo sapiens_hsa033201.74577312
26Sulfur relay system_Homo sapiens_hsa041221.67762435
27Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.62591758
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.59288184
29Ether lipid metabolism_Homo sapiens_hsa005651.54855880
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.53170142
31RNA transport_Homo sapiens_hsa030131.50772768
32Base excision repair_Homo sapiens_hsa034101.49381760
33Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.48309484
34Fanconi anemia pathway_Homo sapiens_hsa034601.42559773
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.42078291
36Mismatch repair_Homo sapiens_hsa034301.38976970
37Non-homologous end-joining_Homo sapiens_hsa034501.36663112
38Steroid hormone biosynthesis_Homo sapiens_hsa001401.35349092
39Alzheimers disease_Homo sapiens_hsa050101.35126161
40Glycerolipid metabolism_Homo sapiens_hsa005611.33841358
41Vitamin digestion and absorption_Homo sapiens_hsa049771.33229250
42Salivary secretion_Homo sapiens_hsa049701.30595452
43Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.28927768
44Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.23620082
45Propanoate metabolism_Homo sapiens_hsa006401.18238804
46Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.17388716
47Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.13484194
48Serotonergic synapse_Homo sapiens_hsa047261.13269580
49Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.12233766
50Pyrimidine metabolism_Homo sapiens_hsa002401.11972050
51Complement and coagulation cascades_Homo sapiens_hsa046101.08582636
52Primary bile acid biosynthesis_Homo sapiens_hsa001201.07649579
532-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.07438862
54alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.02782395
55Butanoate metabolism_Homo sapiens_hsa006501.01622489
56Calcium signaling pathway_Homo sapiens_hsa040201.01522841
57Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.00685269
58Renin secretion_Homo sapiens_hsa049241.00320810
59Lysosome_Homo sapiens_hsa041420.99665081
60Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.98408112
61One carbon pool by folate_Homo sapiens_hsa006700.97870113
62Gastric acid secretion_Homo sapiens_hsa049710.97063613
63Metabolic pathways_Homo sapiens_hsa011000.96764900
64beta-Alanine metabolism_Homo sapiens_hsa004100.95192032
65Phototransduction_Homo sapiens_hsa047440.94735340
66Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.94671633
67Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.94667913
68Bile secretion_Homo sapiens_hsa049760.93186968
69Nicotine addiction_Homo sapiens_hsa050330.92352112
70Fat digestion and absorption_Homo sapiens_hsa049750.91176621
71Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.89444604
72Phenylalanine metabolism_Homo sapiens_hsa003600.87796560
73Pyruvate metabolism_Homo sapiens_hsa006200.87284872
74Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.85515579
75GABAergic synapse_Homo sapiens_hsa047270.85031667
76Long-term potentiation_Homo sapiens_hsa047200.82226865
77Collecting duct acid secretion_Homo sapiens_hsa049660.78983199
78Starch and sucrose metabolism_Homo sapiens_hsa005000.78318461
79Estrogen signaling pathway_Homo sapiens_hsa049150.76378356
80Pancreatic secretion_Homo sapiens_hsa049720.75354910
81Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.74756297
82Vibrio cholerae infection_Homo sapiens_hsa051100.72937763
83Fatty acid biosynthesis_Homo sapiens_hsa000610.72091251
84Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.70777666
85Nucleotide excision repair_Homo sapiens_hsa034200.70685897
86Histidine metabolism_Homo sapiens_hsa003400.70176579
87Prion diseases_Homo sapiens_hsa050200.70167056
88Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.69907430
89Arginine and proline metabolism_Homo sapiens_hsa003300.69146583
90Dorso-ventral axis formation_Homo sapiens_hsa043200.67906542
91Circadian entrainment_Homo sapiens_hsa047130.64721695
92Fatty acid elongation_Homo sapiens_hsa000620.64549268
93Aldosterone synthesis and secretion_Homo sapiens_hsa049250.62689091
94Cyanoamino acid metabolism_Homo sapiens_hsa004600.61073637
95Staphylococcus aureus infection_Homo sapiens_hsa051500.59194281
96Maturity onset diabetes of the young_Homo sapiens_hsa049500.56479714
97Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.55666771
98Carbon metabolism_Homo sapiens_hsa012000.55545075
99Vitamin B6 metabolism_Homo sapiens_hsa007500.55279923
100RNA degradation_Homo sapiens_hsa030180.54043688
101Synaptic vesicle cycle_Homo sapiens_hsa047210.53839544
102Amphetamine addiction_Homo sapiens_hsa050310.53100201
103Purine metabolism_Homo sapiens_hsa002300.52242253
104Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.51784392
105Olfactory transduction_Homo sapiens_hsa047400.49698946
106Ovarian steroidogenesis_Homo sapiens_hsa049130.49575850
107Biosynthesis of amino acids_Homo sapiens_hsa012300.49229558
108Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.48909181
109Lysine degradation_Homo sapiens_hsa003100.48186512
110Folate biosynthesis_Homo sapiens_hsa007900.47574212
111Vascular smooth muscle contraction_Homo sapiens_hsa042700.46281219
112Glutamatergic synapse_Homo sapiens_hsa047240.45599355
113Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.44465760
114Peroxisome_Homo sapiens_hsa041460.44258248
115Tyrosine metabolism_Homo sapiens_hsa003500.42590507
116Leukocyte transendothelial migration_Homo sapiens_hsa046700.42261390
117Pentose and glucuronate interconversions_Homo sapiens_hsa000400.42056081
118Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.41282531
119Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.41247582
120Insulin secretion_Homo sapiens_hsa049110.40020491
121Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.39385252
122Galactose metabolism_Homo sapiens_hsa000520.38588884
123Chemical carcinogenesis_Homo sapiens_hsa052040.38538372
124Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.37685828
125Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.36611857
126Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.36369742
127Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.36351437
128Epstein-Barr virus infection_Homo sapiens_hsa051690.36127625
129Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.35993101
130Adipocytokine signaling pathway_Homo sapiens_hsa049200.35940108
131ABC transporters_Homo sapiens_hsa020100.34999006
132Cardiac muscle contraction_Homo sapiens_hsa042600.34733883
133Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.33418203
134Glycerophospholipid metabolism_Homo sapiens_hsa005640.33096464
135Glucagon signaling pathway_Homo sapiens_hsa049220.32979606
136Glioma_Homo sapiens_hsa052140.31852048
137N-Glycan biosynthesis_Homo sapiens_hsa005100.31252846
138Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.30917409
139Dopaminergic synapse_Homo sapiens_hsa047280.30800200
140GnRH signaling pathway_Homo sapiens_hsa049120.30447757
141Cysteine and methionine metabolism_Homo sapiens_hsa002700.29725955
142Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.29210503
143Spliceosome_Homo sapiens_hsa030400.28957109
144Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.28807576
145cAMP signaling pathway_Homo sapiens_hsa040240.27648536
146cGMP-PKG signaling pathway_Homo sapiens_hsa040220.26812254
147Protein digestion and absorption_Homo sapiens_hsa049740.26678040
148Cholinergic synapse_Homo sapiens_hsa047250.26130877
149Cocaine addiction_Homo sapiens_hsa050300.24509333
150Melanogenesis_Homo sapiens_hsa049160.24506560
151Taste transduction_Homo sapiens_hsa047420.23145427
152Insulin resistance_Homo sapiens_hsa049310.23003515
153Oxytocin signaling pathway_Homo sapiens_hsa049210.18553641
154p53 signaling pathway_Homo sapiens_hsa041150.17718259

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