CLPTM1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sodium ion export (GO:0071436)4.60233513
2lysine metabolic process (GO:0006553)4.37292118
3lysine catabolic process (GO:0006554)4.37292118
4regulation of cholesterol homeostasis (GO:2000188)4.15190501
5alpha-linolenic acid metabolic process (GO:0036109)3.86460082
6negative regulation of cell size (GO:0045792)3.76903963
7basement membrane organization (GO:0071711)3.72143732
8barbed-end actin filament capping (GO:0051016)3.61146945
9regulation of early endosome to late endosome transport (GO:2000641)3.52110573
10regulation of fatty acid beta-oxidation (GO:0031998)3.51172914
11adherens junction assembly (GO:0034333)3.45726658
12CDP-diacylglycerol metabolic process (GO:0046341)3.42289968
13cysteine metabolic process (GO:0006534)3.42176095
14cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.36971967
15cell-substrate adherens junction assembly (GO:0007045)3.31305388
16focal adhesion assembly (GO:0048041)3.31305388
17aspartate family amino acid catabolic process (GO:0009068)3.31250979
18sulfur amino acid catabolic process (GO:0000098)3.28243116
192-oxoglutarate metabolic process (GO:0006103)3.27650718
20cytoskeletal anchoring at plasma membrane (GO:0007016)3.26682628
21tricarboxylic acid metabolic process (GO:0072350)3.25852422
22cell-substrate junction assembly (GO:0007044)3.20498501
23positive regulation of triglyceride biosynthetic process (GO:0010867)3.20078996
24regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.18898949
25skin morphogenesis (GO:0043589)3.16200110
26cellular potassium ion homeostasis (GO:0030007)3.12820683
27phosphate ion transport (GO:0006817)3.12048739
28dicarboxylic acid biosynthetic process (GO:0043650)3.11625496
29CDP-diacylglycerol biosynthetic process (GO:0016024)3.10209823
30phosphate ion transmembrane transport (GO:0035435)3.10089695
31semaphorin-plexin signaling pathway (GO:0071526)3.10077740
32cell communication by electrical coupling (GO:0010644)3.09738678
33negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.06694817
34COPI coating of Golgi vesicle (GO:0048205)3.06643573
35Golgi transport vesicle coating (GO:0048200)3.06643573
36sexual reproduction (GO:0019953)3.05702149
37synaptic vesicle maturation (GO:0016188)3.04668682
38activation of Rac GTPase activity (GO:0032863)3.01792669
39regulation of mammary gland epithelial cell proliferation (GO:0033599)3.00785688
40low-density lipoprotein particle clearance (GO:0034383)2.99108392
41positive regulation of fatty acid beta-oxidation (GO:0032000)2.97104133
42regulation of glucose import in response to insulin stimulus (GO:2001273)2.96635923
43hemidesmosome assembly (GO:0031581)2.95724793
44regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.93635257
45apoptotic cell clearance (GO:0043277)2.91956319
46cellular modified amino acid catabolic process (GO:0042219)2.91894429
47regulation of cholesterol biosynthetic process (GO:0045540)2.88970852
48negative regulation of erythrocyte differentiation (GO:0045647)2.88649521
49apoptotic process involved in morphogenesis (GO:0060561)2.88403862
50glucose 6-phosphate metabolic process (GO:0051156)2.88175857
51pentose-phosphate shunt (GO:0006098)2.86544657
52protein maturation by protein folding (GO:0022417)2.86330632
53activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.86219382
54macroautophagy (GO:0016236)2.85997436
55regulation of cholesterol storage (GO:0010885)2.85416368
56regulation of fatty acid oxidation (GO:0046320)2.84164649
57triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.81990232
58erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.81941492
59L-phenylalanine metabolic process (GO:0006558)2.81941492
60stress fiber assembly (GO:0043149)2.81906221
614-hydroxyproline metabolic process (GO:0019471)2.81350175
62protein localization to endosome (GO:0036010)2.80627722
63glutamate metabolic process (GO:0006536)2.80347040
64synaptic vesicle docking involved in exocytosis (GO:0016081)2.79182971
65positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.78909408
66positive regulation of triglyceride metabolic process (GO:0090208)2.78568080
67fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.77410498
68endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.76134684
69protein targeting to plasma membrane (GO:0072661)2.75664423
70alanine transport (GO:0032328)2.74076741
71regulation of extracellular matrix disassembly (GO:0010715)2.74027922
72epithelial cell differentiation involved in prostate gland development (GO:0060742)2.73989602
73positive regulation of nuclease activity (GO:0032075)2.73959121
74layer formation in cerebral cortex (GO:0021819)2.73466361
75activation of protein kinase A activity (GO:0034199)2.73231822
76proline biosynthetic process (GO:0006561)2.72972257
77maternal placenta development (GO:0001893)2.70321492
78glyoxylate metabolic process (GO:0046487)2.70179392
79desmosome organization (GO:0002934)2.69502605
80cerebellar Purkinje cell layer development (GO:0021680)2.69254420
81regulation of NFAT protein import into nucleus (GO:0051532)2.68449158
82cellular sodium ion homeostasis (GO:0006883)2.68183013
83cell-cell junction maintenance (GO:0045217)2.65312922
84amino-acid betaine metabolic process (GO:0006577)2.63819455
85positive regulation of receptor recycling (GO:0001921)2.63124851
86planar cell polarity pathway involved in neural tube closure (GO:0090179)2.62767056
87positive regulation of Cdc42 GTPase activity (GO:0043089)2.61883341
88activation of MAPKKK activity (GO:0000185)2.61856879
89positive regulation of fatty acid oxidation (GO:0046321)2.61371408
90negative regulation of sterol transport (GO:0032372)2.61048457
91negative regulation of cholesterol transport (GO:0032375)2.61048457
92adhesion of symbiont to host (GO:0044406)2.60620245
93negative regulation of fatty acid transport (GO:2000192)2.60047326
94cell communication involved in cardiac conduction (GO:0086065)2.59138732
95response to mercury ion (GO:0046689)2.58884475
96protein retention in ER lumen (GO:0006621)2.58784375
97response to laminar fluid shear stress (GO:0034616)2.57740434
98positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.57571606
99positive regulation of fatty acid biosynthetic process (GO:0045723)2.55952469
100positive regulation of protein dephosphorylation (GO:0035307)2.55475588
101negative regulation of lipid transport (GO:0032369)2.55322158
102urate metabolic process (GO:0046415)2.54333904
103endoplasmic reticulum unfolded protein response (GO:0030968)2.54235397
104regulation of translational termination (GO:0006449)2.54168979
105valine metabolic process (GO:0006573)2.54113385
106positive regulation of histone deacetylation (GO:0031065)2.52921306
107epithelial cell-cell adhesion (GO:0090136)2.52883852
108pinocytosis (GO:0006907)2.52225419
109NADH metabolic process (GO:0006734)2.51784904
110negative regulation of fibrinolysis (GO:0051918)2.51052953
111serine family amino acid catabolic process (GO:0009071)2.50510044
112amyloid precursor protein catabolic process (GO:0042987)2.49984412
113locomotory exploration behavior (GO:0035641)2.49915553
114maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.49476031
115L-serine transport (GO:0015825)2.47821498
116regulation of clathrin-mediated endocytosis (GO:2000369)2.47472971
117NADPH regeneration (GO:0006740)2.47261309
118serine transport (GO:0032329)2.47103435
119homocysteine metabolic process (GO:0050667)2.46774748
120embryonic process involved in female pregnancy (GO:0060136)2.44840517
121modulation by virus of host morphology or physiology (GO:0019048)2.44442972
122regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.43832792
123vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.43802230
124ER-nucleus signaling pathway (GO:0006984)2.43581540
125fatty acid homeostasis (GO:0055089)2.43454233
126negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.43151085
127cellular ketone body metabolic process (GO:0046950)2.43047190
128mannose metabolic process (GO:0006013)2.43036949
129positive regulation of extracellular matrix organization (GO:1903055)2.42580625
130potassium ion import (GO:0010107)2.42511126
131regulation of nuclease activity (GO:0032069)2.42498362
132regulation of ARF protein signal transduction (GO:0032012)2.42381513
133modulation by symbiont of host cellular process (GO:0044068)2.42293969
134erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.42105369
135L-phenylalanine catabolic process (GO:0006559)2.42105369
136drug transmembrane transport (GO:0006855)2.42023385
137retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.39078368
138positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.38732607
139positive regulation of fatty acid metabolic process (GO:0045923)2.38094945
140cell adhesion mediated by integrin (GO:0033627)2.37332103
141kynurenine metabolic process (GO:0070189)2.37268616
142drug catabolic process (GO:0042737)2.36949098
143peptidyl-proline hydroxylation (GO:0019511)2.36446664
144serine family amino acid metabolic process (GO:0009069)2.36064066
145urea metabolic process (GO:0019627)2.35658718
146urea cycle (GO:0000050)2.35658718
147acetyl-CoA metabolic process (GO:0006084)2.34913391
148positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.34123412
149cortical actin cytoskeleton organization (GO:0030866)2.34047720
150regulation of p38MAPK cascade (GO:1900744)2.33667188
151tricarboxylic acid cycle (GO:0006099)2.33526532
152regulation of defense response to virus by virus (GO:0050690)2.32949661
153actin filament bundle organization (GO:0061572)2.32786013
154actin filament bundle assembly (GO:0051017)2.32786013
155vesicle coating (GO:0006901)2.32713729
156G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.32485203
157membrane protein ectodomain proteolysis (GO:0006509)2.32243636
158cellular response to unfolded protein (GO:0034620)2.32050673
159positive regulation of blood vessel endothelial cell migration (GO:0043536)2.31690280
160positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.31416059
161hyaluronan catabolic process (GO:0030214)2.31300021
162glucose catabolic process (GO:0006007)2.31298708
163actin filament depolymerization (GO:0030042)2.31194164
164intracellular estrogen receptor signaling pathway (GO:0030520)2.30152197
165regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.28418355
166endothelial cell chemotaxis (GO:0035767)2.25796029
167positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.24705330
168cell volume homeostasis (GO:0006884)2.24401947
169virion attachment to host cell (GO:0019062)2.22158641
170adhesion of symbiont to host cell (GO:0044650)2.22158641
171peptidyl-tyrosine autophosphorylation (GO:0038083)2.21808446
172embryo implantation (GO:0007566)2.20763835
173regulation of extracellular matrix organization (GO:1903053)2.16052597

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.18933106
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.72208748
3* RXR_22158963_ChIP-Seq_LIVER_Mouse2.99033645
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.98448295
5* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.94551881
6LXR_22292898_ChIP-Seq_THP-1_Human2.56190279
7ZNF263_19887448_ChIP-Seq_K562_Human2.52717062
8RARG_19884340_ChIP-ChIP_MEFs_Mouse2.27911805
9* LXR_22158963_ChIP-Seq_LIVER_Mouse2.25058167
10KDM2B_26808549_Chip-Seq_SUP-B15_Human2.24551233
11MYC_22102868_ChIP-Seq_BL_Human2.19408215
12CLOCK_20551151_ChIP-Seq_293T_Human2.19321296
13KDM2B_26808549_Chip-Seq_DND41_Human2.13019966
14EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.07198020
15ELK3_25401928_ChIP-Seq_HUVEC_Human2.06610073
16ZFP281_18757296_ChIP-ChIP_E14_Mouse1.99021597
17RACK7_27058665_Chip-Seq_MCF-7_Human1.98658577
18TP63_17297297_ChIP-ChIP_HaCaT_Human1.98193631
19KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.88411077
20THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.87358338
21MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.83362329
22TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.80637689
23KDM2B_26808549_Chip-Seq_K562_Human1.77290808
24ESR2_21235772_ChIP-Seq_MCF-7_Human1.76160078
25TCF7_22412390_ChIP-Seq_EML_Mouse1.73343594
26EGR1_19374776_ChIP-ChIP_THP-1_Human1.71730754
27FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.67987750
28NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.66392270
29EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.65735528
30P300_27058665_Chip-Seq_ZR-75-30cells_Human1.65010274
31ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.63578475
32KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.63364658
33* ATF3_27146783_Chip-Seq_COLON_Human1.61621793
34TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61278656
35VDR_21846776_ChIP-Seq_THP-1_Human1.58801531
36P68_20966046_ChIP-Seq_HELA_Human1.57650896
37KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.57161032
38CREB1_26743006_Chip-Seq_LNCaP_Human1.55601254
39NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.50385882
40ESR1_15608294_ChIP-ChIP_MCF-7_Human1.49586620
41NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.48763957
42TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.47331587
43DNAJC2_21179169_ChIP-ChIP_NT2_Human1.44382508
44DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.42663037
45UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.41451317
46KDM2B_26808549_Chip-Seq_JURKAT_Human1.40815125
47SMC4_20622854_ChIP-Seq_HELA_Human1.39310867
48ERG_21242973_ChIP-ChIP_JURKAT_Human1.37752332
49CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.34451192
50KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.33453711
51WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.32061721
52ZFP281_27345836_Chip-Seq_ESCs_Mouse1.32022577
53SRY_22984422_ChIP-ChIP_TESTIS_Rat1.31631695
54PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.31551911
55* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.31212704
56RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.29906402
57TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.29494195
58TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.26569031
59SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.25607855
60CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.25540842
61VDR_24763502_ChIP-Seq_THP-1_Human1.24960694
62SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.24210317
63GATA1_19941826_ChIP-Seq_K562_Human1.23787386
64EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.23538874
65ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.23233509
66POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.22389453
67GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.22337897
68SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.22168319
69ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.21770518
70BCOR_27268052_Chip-Seq_Bcells_Human1.20386753
71SA1_27219007_Chip-Seq_ERYTHROID_Human1.18282655
72* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.17865390
73CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.17702477
74ELF1_20517297_ChIP-Seq_JURKAT_Human1.17331694
75GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.17252132
76DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.15577996
77* RARB_27405468_Chip-Seq_BRAIN_Mouse1.13571676
78RUNX1_27514584_Chip-Seq_MCF-7_Human1.13357571
79TRIM28_21343339_ChIP-Seq_HEK293_Human1.13206310
80TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.12550573
81CTCF_27219007_Chip-Seq_ERYTHROID_Human1.11434676
82PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10438556
83TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.10297388
84TET1_21490601_ChIP-Seq_MESCs_Mouse1.10232602
85TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.09893982
86CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.09750815
87* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.09675719
88BCL6_27268052_Chip-Seq_Bcells_Human1.09155667
89FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.09147020
90CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.08868135
91TP53_22127205_ChIP-Seq_IMR90_Human1.08775566
92FOXA2_19822575_ChIP-Seq_HepG2_Human1.08105666
93SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.07993433
94MAF_26560356_Chip-Seq_TH1_Human1.07850997
95* TBX20_22080862_ChIP-Seq_HEART_Mouse1.07799107
96* TBX20_22328084_ChIP-Seq_HEART_Mouse1.07799107
97SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.07579669
98TP63_22573176_ChIP-Seq_HFKS_Human1.07444075
99ESR1_21235772_ChIP-Seq_MCF-7_Human1.07001093
100RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.06354575
101TET1_21451524_ChIP-Seq_MESCs_Mouse1.06118901
102SOX2_27498859_Chip-Seq_STOMACH_Mouse1.05261236
103GATA1_19941827_ChIP-Seq_MEL_Mouse1.04734184
104HIF1A_21447827_ChIP-Seq_MCF-7_Human1.04373410
105FOXO3_23340844_ChIP-Seq_DLD1_Human1.03683835
106ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.03642753
107* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.03173903
108SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.03126638
109STAT6_21828071_ChIP-Seq_BEAS2B_Human1.02963186
110CTCF_27219007_Chip-Seq_Bcells_Human1.02593117
111* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.02310881
112UTX_26944678_Chip-Seq_JUKART_Human1.01467246
113UBF1/2_26484160_Chip-Seq_HMECs_Human1.01318571
114SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.01203734
115ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.00510247
116* RUNX1_22412390_ChIP-Seq_EML_Mouse1.00375084
117STAT3_1855785_ChIP-Seq_MESCs_Mouse0.99831702
118TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.99667563
119PHF8_20622854_ChIP-Seq_HELA_Human0.99213000
120* CTCF_21964334_ChIP-Seq_BJAB-B_Human0.99155742
121P63_26484246_Chip-Seq_KERATINOCYTES_Human0.98962146
122RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.98602945
123* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.97815342
124HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.96750223
125* NCOR1_26117541_ChIP-Seq_K562_Human0.95970674
126SMC1_22415368_ChIP-Seq_MEFs_Mouse0.95580870
127SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.95554154

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis4.07624651
2MP0003705_abnormal_hypodermis_morpholog3.82542302
3MP0009840_abnormal_foam_cell3.76309133
4MP0002139_abnormal_hepatobiliary_system3.31220143
5MP0005451_abnormal_body_composition3.25714806
6MP0003300_gastrointestinal_ulcer2.84028955
7MP0010234_abnormal_vibrissa_follicle2.78379016
8MP0008260_abnormal_autophagy2.50633330
9MP0002877_abnormal_melanocyte_morpholog2.38599222
10MP0003303_peritoneal_inflammation2.30600883
11MP0003191_abnormal_cellular_cholesterol2.30181361
12MP0003329_amyloid_beta_deposits2.27524975
13MP0005365_abnormal_bile_salt2.26305228
14MP0005058_abnormal_lysosome_morphology2.24150155
15MP0005085_abnormal_gallbladder_physiolo2.19630142
16MP0008961_abnormal_basal_metabolism2.09708517
17MP0005257_abnormal_intraocular_pressure2.07655888
18MP0004859_abnormal_synaptic_plasticity2.05742288
19MP0003283_abnormal_digestive_organ2.04296627
20MP0010329_abnormal_lipoprotein_level1.96474918
21MP0002796_impaired_skin_barrier1.95064257
22MP0003252_abnormal_bile_duct1.90709482
23MP0004858_abnormal_nervous_system1.88751736
24MP0003453_abnormal_keratinocyte_physiol1.88694303
25MP0008875_abnormal_xenobiotic_pharmacok1.88488820
26MP0002909_abnormal_adrenal_gland1.86670285
27MP0005409_darkened_coat_color1.84222789
28MP0000604_amyloidosis1.80573300
29MP0005332_abnormal_amino_acid1.79047420
30MP0004130_abnormal_muscle_cell1.75411822
31MP0003279_aneurysm1.74818368
32MP0003172_abnormal_lysosome_physiology1.74128125
33MP0005167_abnormal_blood-brain_barrier1.72922462
34MP0002138_abnormal_hepatobiliary_system1.66178150
35MP0002822_catalepsy1.62856626
36MP0005076_abnormal_cell_differentiation1.62675475
37MP0003566_abnormal_cell_adhesion1.62604541
38MP0000678_abnormal_parathyroid_gland1.57699523
39MP0005083_abnormal_biliary_tract1.55416038
40MP0010352_gastrointestinal_tract_polyps1.54180658
41MP0004185_abnormal_adipocyte_glucose1.53923503
42MP0009643_abnormal_urine_homeostasis1.53760135
43MP0001348_abnormal_lacrimal_gland1.53356057
44MP0004019_abnormal_vitamin_homeostasis1.49974415
45MP0005666_abnormal_adipose_tissue1.45956961
46MP0001666_abnormal_nutrient_absorption1.45526664
47MP0000013_abnormal_adipose_tissue1.43167651
48MP0003436_decreased_susceptibility_to1.43110210
49MP0000858_altered_metastatic_potential1.41394684
50MP0002060_abnormal_skin_morphology1.41335992
51MP0000609_abnormal_liver_physiology1.39889039
52MP0005501_abnormal_skin_physiology1.36568315
53MP0000747_muscle_weakness1.32410106
54MP0002118_abnormal_lipid_homeostasis1.31073272
55MP0001756_abnormal_urination1.28331462
56MP0002269_muscular_atrophy1.27698343
57MP0000751_myopathy1.27277332
58MP0003075_altered_response_to1.26961808
59MP0005375_adipose_tissue_phenotype1.25587961
60MP0004084_abnormal_cardiac_muscle1.24860377
61MP0009780_abnormal_chondrocyte_physiolo1.24273309
62MP0002089_abnormal_postnatal_growth/wei1.22462756
63MP0004233_abnormal_muscle_weight1.20341212
64MP0003634_abnormal_glial_cell1.20003573
65MP0005584_abnormal_enzyme/coenzyme_acti1.19534934
66MP0000003_abnormal_adipose_tissue1.16914216
67MP0005319_abnormal_enzyme/_coenzyme1.12042016
68MP0005670_abnormal_white_adipose1.11245108
69MP0004087_abnormal_muscle_fiber1.10349236
70MP0001958_emphysema1.07851694
71MP0001849_ear_inflammation1.07715347
72MP0000920_abnormal_myelination1.06269699
73MP0005275_abnormal_skin_tensile1.05249559
74MP0001765_abnormal_ion_homeostasis1.04822311
75MP0005330_cardiomyopathy1.04545222
76MP0005377_hearing/vestibular/ear_phenot1.04522892
77MP0003878_abnormal_ear_physiology1.04522892
78MP0003879_abnormal_hair_cell1.02894334
79MP0002998_abnormal_bone_remodeling1.02675951
80MP0000767_abnormal_smooth_muscle1.01515531
81MP0010368_abnormal_lymphatic_system0.98123424
82MP0000579_abnormal_nail_morphology0.97812371
83MP0002653_abnormal_ependyma_morphology0.97748584
84MP0000467_abnormal_esophagus_morphology0.97683621
85MP0002249_abnormal_larynx_morphology0.97316495
86MP0004264_abnormal_extraembryonic_tissu0.97045952
87MP0000759_abnormal_skeletal_muscle0.95203286
88MP0003091_abnormal_cell_migration0.92873647
89MP0001533_abnormal_skeleton_physiology0.92741805
90MP0005023_abnormal_wound_healing0.92267901
91MP0005623_abnormal_meninges_morphology0.91696034
92MP0004043_abnormal_pH_regulation0.91485828
93MP0001915_intracranial_hemorrhage0.91346899
94MP0001216_abnormal_epidermal_layer0.90424536
95MP0005621_abnormal_cell_physiology0.90312564
96MP0004885_abnormal_endolymph0.89772007
97MP0002837_dystrophic_cardiac_calcinosis0.89751674
98MP0008438_abnormal_cutaneous_collagen0.89510680
99MP0009672_abnormal_birth_weight0.88214832
100MP0008874_decreased_physiological_sensi0.87027096
101MP0002136_abnormal_kidney_physiology0.85161690
102MP0005165_increased_susceptibility_to0.85053699
103MP0000598_abnormal_liver_morphology0.84077159
104MP0004782_abnormal_surfactant_physiolog0.82875741
105MP0003646_muscle_fatigue0.82326254
106MP0003183_abnormal_peptide_metabolism0.81605540
107MP0002254_reproductive_system_inflammat0.80358649
108MP0000750_abnormal_muscle_regeneration0.79712776
109MP0000681_abnormal_thyroid_gland0.79050982
110MP0004510_myositis0.78849082
111MP0005166_decreased_susceptibility_to0.78650990
112MP0010630_abnormal_cardiac_muscle0.77776114
113MP0006138_congestive_heart_failure0.77707749
114MP0003448_altered_tumor_morphology0.76773090
115MP0003656_abnormal_erythrocyte_physiolo0.75578198
116MP0003045_fibrosis0.75471804
117MP0000462_abnormal_digestive_system0.75238464
118MP0005508_abnormal_skeleton_morphology0.74613789
119MP0002971_abnormal_brown_adipose0.74561331
120MP0005390_skeleton_phenotype0.72893505
121MP0002078_abnormal_glucose_homeostasis0.72364882
122MP0003195_calcinosis0.72231930
123MP0003221_abnormal_cardiomyocyte_apopto0.71587492
124MP0004215_abnormal_myocardial_fiber0.71014055
125MP0000343_altered_response_to0.70651620
126MP0009333_abnormal_splenocyte_physiolog0.69217670
127MP0009931_abnormal_skin_appearance0.69020324
128MP0009384_cardiac_valve_regurgitation0.68531490
129MP0000537_abnormal_urethra_morphology0.68170267
130MP0003690_abnormal_glial_cell0.68090084
131MP0003806_abnormal_nucleotide_metabolis0.67688921
132MP0009053_abnormal_anal_canal0.66724202
133MP0009278_abnormal_bone_marrow0.66580434
134MP0002234_abnormal_pharynx_morphology0.66538610
135MP0005636_abnormal_mineral_homeostasis0.66513832
136MP0004036_abnormal_muscle_relaxation0.66386720
137MP0002970_abnormal_white_adipose0.65759883
138MP0002090_abnormal_vision0.65160441
139MP0004947_skin_inflammation0.64921237
140MP0010771_integument_phenotype0.64894928
141MP0001243_abnormal_dermal_layer0.64287018
142MP0000733_abnormal_muscle_development0.61538458
143MP0001542_abnormal_bone_strength0.61434211
144MP0008775_abnormal_heart_ventricle0.61418997
145MP0000534_abnormal_ureter_morphology0.61028752
146MP0002896_abnormal_bone_mineralization0.60669650
147MP0004272_abnormal_basement_membrane0.60292393

Predicted human phenotypes

RankGene SetZ-score
1Vertebral compression fractures (HP:0002953)3.42989279
2Gout (HP:0001997)3.24935040
3Xanthomatosis (HP:0000991)3.19703881
4Cerebral aneurysm (HP:0004944)3.09965404
5Deep venous thrombosis (HP:0002625)3.03902821
6Abnormality of the Achilles tendon (HP:0005109)3.01753064
7Distal upper limb amyotrophy (HP:0007149)2.93870933
8Upper limb amyotrophy (HP:0009129)2.93870933
9Achilles tendon contracture (HP:0001771)2.90425741
10Neurofibrillary tangles (HP:0002185)2.83728527
11Polycythemia (HP:0001901)2.76818807
12Distal lower limb amyotrophy (HP:0008944)2.75175318
13Hand muscle atrophy (HP:0009130)2.74801639
14Distal lower limb muscle weakness (HP:0009053)2.66791375
15Obstructive sleep apnea (HP:0002870)2.60692884
16Dysostosis multiplex (HP:0000943)2.60363806
17Broad face (HP:0000283)2.57346373
18Hypoalphalipoproteinemia (HP:0003233)2.53959219
19Cervical subluxation (HP:0003308)2.53331468
20Abnormality of the lower motor neuron (HP:0002366)2.52178564
21Abnormality of glutamine family amino acid metabolism (HP:0010902)2.51716955
22Increased connective tissue (HP:0009025)2.49982599
23Abnormality of glycolipid metabolism (HP:0010969)2.49531636
24Abnormality of liposaccharide metabolism (HP:0010968)2.49531636
25Abnormality of glycosphingolipid metabolism (HP:0004343)2.49531636
26Protrusio acetabuli (HP:0003179)2.48231452
27Axonal loss (HP:0003447)2.46151659
28Ketosis (HP:0001946)2.44574351
29Ulnar bowing (HP:0003031)2.44167569
30Atrophic scars (HP:0001075)2.41172602
31Ketoacidosis (HP:0001993)2.37872469
32Spinal rigidity (HP:0003306)2.36833672
33Hyperammonemia (HP:0001987)2.36713969
34Mucopolysacchariduria (HP:0008155)2.34747923
35Urinary glycosaminoglycan excretion (HP:0003541)2.34747923
36Fragile skin (HP:0001030)2.34195308
37Hyperacusis (HP:0010780)2.33367204
38Hyperglycinuria (HP:0003108)2.28477309
39Thin bony cortex (HP:0002753)2.27410379
40Lymphangioma (HP:0100764)2.26185658
41Centrally nucleated skeletal muscle fibers (HP:0003687)2.24841936
42Ventricular fibrillation (HP:0001663)2.21906450
43Hyperparathyroidism (HP:0000843)2.21384347
44Abnormality of polysaccharide metabolism (HP:0011012)2.20436264
45Abnormality of glycosaminoglycan metabolism (HP:0004371)2.20436264
46Abnormality of mucopolysaccharide metabolism (HP:0011020)2.20436264
47J-shaped sella turcica (HP:0002680)2.18724870
48Asymmetric septal hypertrophy (HP:0001670)2.18597511
49Back pain (HP:0003418)2.18396745
50Increased variability in muscle fiber diameter (HP:0003557)2.18100264
51Insomnia (HP:0100785)2.17934260
52Short nail (HP:0001799)2.17032862
53Complement deficiency (HP:0004431)2.16973509
54Global brain atrophy (HP:0002283)2.16236778
55Lower limb amyotrophy (HP:0007210)2.14579346
56Late onset (HP:0003584)2.12478452
57Difficulty climbing stairs (HP:0003551)2.12473825
58Ankle contracture (HP:0006466)2.11755531
59Aneurysm (HP:0002617)2.08149010
60Abnormality of glycine metabolism (HP:0010895)2.07591590
61Abnormality of serine family amino acid metabolism (HP:0010894)2.07591590
62Abnormality of monocarboxylic acid metabolism (HP:0010996)2.06763679
63Hyperlipoproteinemia (HP:0010980)2.06591377
64Bundle branch block (HP:0011710)2.05994467
65Hypoglycemic coma (HP:0001325)2.05508029
66Hypercortisolism (HP:0001578)2.04834345
67Right ventricular cardiomyopathy (HP:0011663)2.04795626
68Increased cerebral lipofuscin (HP:0011813)2.04045772
69Mildly elevated creatine phosphokinase (HP:0008180)2.04020910
70Hemorrhage of the eye (HP:0011885)2.04015723
71Sensorimotor neuropathy (HP:0007141)2.03701948
72Nuclear cataract (HP:0100018)2.03596192
73Abnormality of purine metabolism (HP:0004352)2.03477476
74Hyperuricemia (HP:0002149)2.02366710
75Increased purine levels (HP:0004368)2.02366710
76Neonatal onset (HP:0003623)2.02188961
77Wormian bones (HP:0002645)1.99304112
78Hydroxyprolinuria (HP:0003080)1.99234388
79Abnormality of proline metabolism (HP:0010907)1.99234388
80Abnormality of skeletal muscle fiber size (HP:0012084)1.98980307
81Turricephaly (HP:0000262)1.98690182
82Vascular tortuosity (HP:0004948)1.97250530
83Mitral regurgitation (HP:0001653)1.96681304
84Shallow orbits (HP:0000586)1.96664717
85Esophageal varix (HP:0002040)1.96278146
86Loss of speech (HP:0002371)1.94689554
87Blue sclerae (HP:0000592)1.94334851
88Long palpebral fissure (HP:0000637)1.93155812
89Abnormality of aromatic amino acid family metabolism (HP:0004338)1.92103943
90Myoglobinuria (HP:0002913)1.92002363
91Disproportionate tall stature (HP:0001519)1.91981732
92Arterial tortuosity (HP:0005116)1.91951179
93Polygenic inheritance (HP:0010982)1.91667849
94Abnormality of the distal phalanges of the toes (HP:0010182)1.90657504
95Long toe (HP:0010511)1.90553098
96Abnormal gallbladder physiology (HP:0012438)1.89688581
97Cholecystitis (HP:0001082)1.89688581
98Systemic lupus erythematosus (HP:0002725)1.89144845
99Premature rupture of membranes (HP:0001788)1.88647040
100Enlarged penis (HP:0000040)1.88573332
101Spastic diplegia (HP:0001264)1.88215697
102Genu recurvatum (HP:0002816)1.87878505
103Neuronal loss in central nervous system (HP:0002529)1.87504895
104Stridor (HP:0010307)1.86914437
105Hypolipoproteinemia (HP:0010981)1.86653955
106Elfin facies (HP:0004428)1.86405005
107Generalized amyotrophy (HP:0003700)1.83364993
108Bladder diverticulum (HP:0000015)1.81851816
109Sudden death (HP:0001699)1.81110790
110Intrahepatic cholestasis (HP:0001406)1.79134634
111Hemiplegia (HP:0002301)1.78824822
112Atrioventricular block (HP:0001678)1.78446685
113Mitral valve prolapse (HP:0001634)1.78196127
114Aortic aneurysm (HP:0004942)1.77032275
115Elbow flexion contracture (HP:0002987)1.76964445
116Cerebral inclusion bodies (HP:0100314)1.76813602
117Biconcave vertebral bodies (HP:0004586)1.76457772
118Myocardial infarction (HP:0001658)1.76339872
119Difficulty running (HP:0009046)1.75675138
120Visceral angiomatosis (HP:0100761)1.75345694
121Mitral stenosis (HP:0001718)1.74431078
122Supranuclear gaze palsy (HP:0000605)1.73898659
123Flat acetabular roof (HP:0003180)1.73802609
124Growth hormone excess (HP:0000845)1.73115864
125Myokymia (HP:0002411)1.72770703
126Osteolytic defects of the hand bones (HP:0009699)1.72718201
127Osteolytic defects of the phalanges of the hand (HP:0009771)1.72718201
128Hyperglycinemia (HP:0002154)1.72191849
129Frequent falls (HP:0002359)1.72038176
130Abnormality of complement system (HP:0005339)1.71249851
131Skin nodule (HP:0200036)1.71175429
132Athetosis (HP:0002305)1.71158704
133Limb-girdle muscle atrophy (HP:0003797)1.71105019
134Broad metatarsal (HP:0001783)1.70936972
135Advanced eruption of teeth (HP:0006288)1.70739926
136Malnutrition (HP:0004395)1.69448575
137Cardiomegaly (HP:0001640)1.69214027
138Striae distensae (HP:0001065)1.66747325
139Increased neuronal autofluorescent lipopigment (HP:0002074)1.65369245
140Abnormality of fatty-acid metabolism (HP:0004359)1.64832589
141Acanthosis nigricans (HP:0000956)1.64827042
142Pseudobulbar signs (HP:0002200)1.64672645
143Dysmetric saccades (HP:0000641)1.64465460
144Abnormality of carpal bone ossification (HP:0006257)1.64183668
145Bone pain (HP:0002653)1.63413322
146Hepatocellular carcinoma (HP:0001402)1.63209067
147Subacute progressive viral hepatitis (HP:0006572)1.62570420
148Abnormality of the thoracic spine (HP:0100711)1.62465782
149Status epilepticus (HP:0002133)1.62120354
150Natal tooth (HP:0000695)1.60975763
151Focal segmental glomerulosclerosis (HP:0000097)1.60526162
152Hemangiomatosis (HP:0007461)1.60286500
153Apathy (HP:0000741)1.60212820
154Segmental peripheral demyelination/remyelination (HP:0003481)1.59880025
155Dilatation of the ascending aorta (HP:0005111)1.59579669
156Coxa vara (HP:0002812)1.59420617
157Abnormal ossification of hand bones (HP:0005921)1.59213899
158Reticulocytosis (HP:0001923)1.58919344
159Myopathic facies (HP:0002058)1.58826047
160Amyloidosis (HP:0011034)1.58227018
161Postural instability (HP:0002172)1.57664183
162Distal sensory impairment (HP:0002936)1.57423499
163Increased circulating renin level (HP:0000848)1.56948299
164Interstitial pulmonary disease (HP:0006530)1.55995640
165Pointed chin (HP:0000307)1.55911464

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB35.07560137
2PKN23.51134617
3ERN13.21619904
4SMG12.87333446
5PRPF4B2.78423617
6KSR22.74972852
7IRAK32.70944849
8SCYL22.30377974
9RIPK12.27882672
10PRKD32.24832963
11MAP3K92.21415967
12ARAF2.06568093
13NEK12.03059980
14TAOK12.02058132
15LMTK21.93342280
16SIK11.85875698
17BCKDK1.81688030
18EEF2K1.81250589
19MAP3K101.77060417
20NME21.76130181
21PTK61.61749468
22PAK61.57859133
23TESK21.55546481
24CAMKK11.53217689
25TTN1.46377186
26KDR1.44884016
27PDGFRA1.29162237
28FGFR41.29118027
29MAP3K21.27628161
30ICK1.27547819
31DAPK21.23495748
32RET1.21544107
33MAP3K31.20646400
34MAP3K131.20405814
35TYRO31.19208150
36PAK41.18496884
37LRRK21.17610104
38MST1R1.16333211
39TESK11.15467816
40PIM21.14733573
41ALK1.11717456
42MARK21.09606118
43BMX1.08042159
44PTK21.07556294
45MAP3K111.06507036
46STK381.05629779
47NTRK11.04885682
48MOS0.97840652
49EPHA20.97742561
50PDK30.95301941
51PDK40.95301941
52CDC42BPA0.94201242
53LIMK10.91957859
54BRAF0.90962274
55DMPK0.88782718
56TBK10.88163437
57PDPK10.87277857
58CAMK1D0.86598131
59MINK10.84549677
60LATS20.82953583
61EPHB10.82900355
62MAP3K10.82193453
63MAP3K80.78962500
64WNK40.78535824
65PAK30.78317992
66MTOR0.76266771
67MAP2K10.75482513
68MAP2K20.74600470
69PRKCH0.74256220
70DAPK30.73801025
71FER0.71850069
72PDK10.69387926
73DYRK1B0.69237349
74KSR10.69136541
75MAP3K70.69050902
76PHKG20.67853780
77PHKG10.67853780
78SIK30.67231232
79JAK20.65297539
80CAMK1G0.65256090
81SIK20.63666286
82GRK60.62916117
83WNK30.62627290
84DDR20.61297038
85NEK20.60644873
86PAK20.60191792
87EPHA40.58954539
88RIPK40.58294143
89IRAK20.56353762
90TGFBR20.55945892
91PRKD10.54582287
92STK110.54132073
93JAK10.52022517
94MAP3K60.51170742
95ERBB20.51094266
96ABL20.49652626
97MAPK110.48854271
98FGFR10.47852101
99RPS6KL10.47655654
100RPS6KC10.47655654
101CAMK2G0.46993628
102MAP2K40.46752253
103TAOK30.46399910
104ILK0.46259623
105DAPK10.45827778
106CDK11A0.44996837
107ZAP700.43771081
108STK100.43674161
109MAP4K10.43257861
110MET0.43232382
111EPHB20.42739095
112HIPK20.42563526
113MAPK120.42552591
114PRKG20.40667247
115PRKCZ0.40272567
116CDK50.39629250
117TYK20.38728440
118CDK180.38623963
119PDK20.38547197
120MAPKAPK30.38378268
121TAOK20.38299024
122RAF10.38138503
123CDK140.37920577
124MAP2K30.37233857
125PRKAA10.36922875
126PRKD20.36312748
127CDK120.36165183
128ROCK10.35674420
129ROCK20.35494132
130AKT20.35151772
131CDK70.34864026
132CDK90.34236430
133CAMK2B0.33374088
134RPS6KA20.32960289
135CDK150.32675686
136SGK30.32551035

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.46638055
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.07142657
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.53233777
4Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.50231136
5Arginine biosynthesis_Homo sapiens_hsa002202.18969658
6Bile secretion_Homo sapiens_hsa049762.07335760
7Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.06517660
8Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.02811880
9Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.01646568
10Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.99451381
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.96516627
12Fatty acid degradation_Homo sapiens_hsa000711.90404144
13Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.83088944
14Primary bile acid biosynthesis_Homo sapiens_hsa001201.69391784
15Acute myeloid leukemia_Homo sapiens_hsa052211.57184576
16PPAR signaling pathway_Homo sapiens_hsa033201.53906905
17Carbon metabolism_Homo sapiens_hsa012001.51257206
18Biosynthesis of amino acids_Homo sapiens_hsa012301.45530823
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.45338330
20Fatty acid metabolism_Homo sapiens_hsa012121.44509291
21Butanoate metabolism_Homo sapiens_hsa006501.43990945
22Vibrio cholerae infection_Homo sapiens_hsa051101.43422762
23Notch signaling pathway_Homo sapiens_hsa043301.36357267
24Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.32582199
25Tryptophan metabolism_Homo sapiens_hsa003801.26880401
26Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.26747350
27Cyanoamino acid metabolism_Homo sapiens_hsa004601.24312175
28Amoebiasis_Homo sapiens_hsa051461.15976472
29Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.13299193
30Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.12426926
31Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.05491538
32Fat digestion and absorption_Homo sapiens_hsa049751.05414232
33Propanoate metabolism_Homo sapiens_hsa006401.02787697
34Bladder cancer_Homo sapiens_hsa052191.01825940
35Adipocytokine signaling pathway_Homo sapiens_hsa049201.01760034
36AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.00805601
37ErbB signaling pathway_Homo sapiens_hsa040121.00012649
38Pyruvate metabolism_Homo sapiens_hsa006200.99427424
39Central carbon metabolism in cancer_Homo sapiens_hsa052300.99038555
40Phenylalanine metabolism_Homo sapiens_hsa003600.98221407
41Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.96863943
42Lysosome_Homo sapiens_hsa041420.96761445
43ECM-receptor interaction_Homo sapiens_hsa045120.93800804
44Sulfur relay system_Homo sapiens_hsa041220.93575851
45Carbohydrate digestion and absorption_Homo sapiens_hsa049730.92141967
46Glycerolipid metabolism_Homo sapiens_hsa005610.91447120
47Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.91292414
48Caffeine metabolism_Homo sapiens_hsa002320.89914374
49Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.89804399
50Insulin resistance_Homo sapiens_hsa049310.89373911
51Pentose phosphate pathway_Homo sapiens_hsa000300.89032706
52Salmonella infection_Homo sapiens_hsa051320.88316908
53mTOR signaling pathway_Homo sapiens_hsa041500.85928633
54Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.85903235
55Glioma_Homo sapiens_hsa052140.85669411
56VEGF signaling pathway_Homo sapiens_hsa043700.84595639
57Glycosaminoglycan degradation_Homo sapiens_hsa005310.84574057
58Toll-like receptor signaling pathway_Homo sapiens_hsa046200.83497288
59Pentose and glucuronate interconversions_Homo sapiens_hsa000400.82385475
60Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.82176143
61Gastric acid secretion_Homo sapiens_hsa049710.81934450
62Leukocyte transendothelial migration_Homo sapiens_hsa046700.81620340
63Insulin signaling pathway_Homo sapiens_hsa049100.81590425
64Hepatitis C_Homo sapiens_hsa051600.81564778
65Osteoclast differentiation_Homo sapiens_hsa043800.80584328
66Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.79721060
67Lysine degradation_Homo sapiens_hsa003100.78335204
68AMPK signaling pathway_Homo sapiens_hsa041520.77403615
69Shigellosis_Homo sapiens_hsa051310.77337033
70Chronic myeloid leukemia_Homo sapiens_hsa052200.77275416
71Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.74986344
72Type II diabetes mellitus_Homo sapiens_hsa049300.74805397
73Prion diseases_Homo sapiens_hsa050200.74503144
74Vitamin B6 metabolism_Homo sapiens_hsa007500.74386343
75Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.73960037
76Complement and coagulation cascades_Homo sapiens_hsa046100.73878502
77TNF signaling pathway_Homo sapiens_hsa046680.73121568
78Synaptic vesicle cycle_Homo sapiens_hsa047210.71596218
79Sphingolipid signaling pathway_Homo sapiens_hsa040710.71517258
80Selenocompound metabolism_Homo sapiens_hsa004500.70732064
81B cell receptor signaling pathway_Homo sapiens_hsa046620.70199794
82Non-small cell lung cancer_Homo sapiens_hsa052230.70100146
83Fructose and mannose metabolism_Homo sapiens_hsa000510.69839631
84Thyroid hormone signaling pathway_Homo sapiens_hsa049190.69345955
85Longevity regulating pathway - mammal_Homo sapiens_hsa042110.69259195
86Small cell lung cancer_Homo sapiens_hsa052220.68439716
87Phosphatidylinositol signaling system_Homo sapiens_hsa040700.68303491
88Adherens junction_Homo sapiens_hsa045200.67732319
89Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.67382697
90Apoptosis_Homo sapiens_hsa042100.67009763
91Estrogen signaling pathway_Homo sapiens_hsa049150.66972390
92Regulation of actin cytoskeleton_Homo sapiens_hsa048100.66972363
93Aldosterone synthesis and secretion_Homo sapiens_hsa049250.66795044
94Fatty acid biosynthesis_Homo sapiens_hsa000610.66724574
95N-Glycan biosynthesis_Homo sapiens_hsa005100.65929277
96Starch and sucrose metabolism_Homo sapiens_hsa005000.65540671
97Endocytosis_Homo sapiens_hsa041440.63821519
98Glucagon signaling pathway_Homo sapiens_hsa049220.63330483
99Endometrial cancer_Homo sapiens_hsa052130.62878566
100Galactose metabolism_Homo sapiens_hsa000520.62636863
101Toxoplasmosis_Homo sapiens_hsa051450.62045175
102Pertussis_Homo sapiens_hsa051330.61322658
103Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.61085266
104beta-Alanine metabolism_Homo sapiens_hsa004100.60702436
105Inositol phosphate metabolism_Homo sapiens_hsa005620.60238067
106Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.59635722
107Dilated cardiomyopathy_Homo sapiens_hsa054140.59520497
108Hepatitis B_Homo sapiens_hsa051610.59045286
109Choline metabolism in cancer_Homo sapiens_hsa052310.58728060
110Mineral absorption_Homo sapiens_hsa049780.58343979
111Proteoglycans in cancer_Homo sapiens_hsa052050.57758583
112Cysteine and methionine metabolism_Homo sapiens_hsa002700.57601215
113Gap junction_Homo sapiens_hsa045400.57477957
114Salivary secretion_Homo sapiens_hsa049700.57079232
115Prolactin signaling pathway_Homo sapiens_hsa049170.56976008
116Insulin secretion_Homo sapiens_hsa049110.56725841
117Thyroid hormone synthesis_Homo sapiens_hsa049180.56517190
118Neurotrophin signaling pathway_Homo sapiens_hsa047220.56166651
119Prostate cancer_Homo sapiens_hsa052150.56155307
120Melanogenesis_Homo sapiens_hsa049160.55402522
121Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.54959842
122Dorso-ventral axis formation_Homo sapiens_hsa043200.53011024
123Focal adhesion_Homo sapiens_hsa045100.50461487
124Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.50170078
125Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.49029793
126Olfactory transduction_Homo sapiens_hsa047400.48916205
127Tuberculosis_Homo sapiens_hsa051520.48587559
128Glycerophospholipid metabolism_Homo sapiens_hsa005640.48473705
129Renal cell carcinoma_Homo sapiens_hsa052110.46551636
130Phospholipase D signaling pathway_Homo sapiens_hsa040720.46410706
131GnRH signaling pathway_Homo sapiens_hsa049120.45004568
132ABC transporters_Homo sapiens_hsa020100.43613024
133Long-term potentiation_Homo sapiens_hsa047200.41824392
134Peroxisome_Homo sapiens_hsa041460.41783326
135Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.41244134
136Other glycan degradation_Homo sapiens_hsa005110.41154835
137Protein digestion and absorption_Homo sapiens_hsa049740.40061781
138Pancreatic cancer_Homo sapiens_hsa052120.39153704
139HIF-1 signaling pathway_Homo sapiens_hsa040660.38507209
140Thyroid cancer_Homo sapiens_hsa052160.38372353
141Drug metabolism - other enzymes_Homo sapiens_hsa009830.37951975

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